Anti-adhesion hydrophilic coating as well as preparation method and application thereof

Abstract

The invention discloses an anti-adhesion hydrophilic coating as well as a preparation method and application thereof. The anti-adhesion hydrophilic coating comprises a first coating composition for forming a bottom layer and a second coating composition for forming a top layer, the first coating composition is prepared from the following components in parts by weight: 1 to 5 parts of anatase type titanium dioxide, 0.01 to 0.1 part of 2-hydroxy-4-methoxybenzophenone, 10 to 20 parts of polyurethane, 0.5 to 3 parts of isophorone diisocyanate, 0.1 to 0.5 part of gamma-methacryloxypropyl trimethoxy silane and 150 to 300 parts of butanone; the second coating composition is prepared from the following components in parts by weight: 5 to 15 parts of polysulfobetaine methacrylate, 0.5 to 3 parts of polyethylene glycol and 100 to 200 parts of absolute ethyl alcohol.

Description

Technical Field

[0001] This invention belongs to the field of medical devices, specifically relating to an anti-adhesion hydrophilic coating, its preparation method, and its application. Background Technology

[0002] Interventional vascular techniques, as a minimally invasive treatment, have been widely used in the fields of cardiovascular and cerebrovascular diseases, and peripheral vascular diseases. This technique uses interventional instruments such as catheters and guidewires to reach the lesion site through the body's natural lumen for diagnosis or treatment, offering significant advantages such as minimal trauma, rapid recovery, and high safety. During the procedure, the interventional instruments need to be pushed and twisted repeatedly over long distances within narrow, tortuous, and blood-filled blood vessels. Therefore, the physicochemical properties of the instrument surface are crucial to the success of the procedure.

[0003] Currently, the mainstream technical solution involves coating the surface of medical devices with a layer of hydrophilic polymers, such as polyvinylpyrrolidone (PVP) and polyethylene glycol (PEG). These coatings rapidly absorb water upon contact with bodily fluids, forming a highly hydrated gel layer that provides significant lubrication. However, these coatings generally exhibit insufficient adhesion to the device substrate. In the complex vascular environment, the coating is easily worn away and detached due to repeated friction and fluid erosion, leading not only to loss of lubrication but also the potential formation of emboli from detached coating fragments, posing serious medical risks. To improve coating adhesion, researchers have experimented with physically blending hydrophilic polymers with tough resins such as polyurethane and acrylates, curing them into films via solvent evaporation or ultraviolet light. However, this method tends to encapsulate hydrophilic polymers inside, preventing them from fully contacting water molecules and resulting in reduced lubrication performance. At the same time, the addition of hydrophilic polymers can interfere with the curing and cross-linking process of the resin base, reducing the overall mechanical strength and density of the coating. Furthermore, some prepolymers or curing agents of strong and tough resins may have certain biotoxicity, and if the reaction is incomplete, their residues may pose safety hazards.

[0004] Therefore, developing a new type of coating that can achieve ultra-low friction and strong anti-adhesion, as well as a firm bond with the substrate and absolute safety, has become a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0005] In order to overcome the above-mentioned shortcomings of the existing technology, the purpose of this invention is to provide an anti-adhesion hydrophilic coating, its preparation method and application, which solves the technical problem of balancing lubricity and durability in the field of vascular interventional coatings.

[0006] The objective of this invention is achieved by at least one of the following technical solutions.

[0007] An anti-adhesion hydrophilic coating includes a first coating composition for forming a base layer and a second coating composition for forming a top layer; The first coating composition comprises, by weight, the following components: 1-5 parts anatase titanium dioxide, 0.01-0.1 parts 2-hydroxy-4-methoxybenzophenone, 10-20 parts polyurethane, 0.5-3 parts isophorone diisocyanate, 0.1-0.5 parts γ-methacryloyloxypropyltrimethoxysilane and 150-300 parts butanone; The second coating composition comprises, by weight, the following components: 5-15 parts polysulfobetaine methacrylate, 0.5-3 parts polyethylene glycol and 100-200 parts anhydrous ethanol.

[0008] Furthermore, the anatase titanium dioxide is surface-modified anatase titanium dioxide.

[0009] Furthermore, the surface-modified anatase titanium dioxide is anatase titanium dioxide coated with silica, and the thickness of the silica coating layer is 1-3 nm.

[0010] Furthermore, the surface-modified anatase titanium dioxide is anatase titanium dioxide with silver nanoparticles loaded on its surface, wherein the silver loading is 0.1-1 wt%.

[0011] Furthermore, the anatase titanium dioxide has an average particle size of 5-50 nm and a specific surface area of ​​50-200 m² / g.

[0012] Furthermore, the mass ratio of the polyurethane to the isophorone diisocyanate is 100:5-100:15, and the weight-average molecular weight of the polyurethane is 50,000-500,000 Da.

[0013] Furthermore, the polysulfonated betaine methacrylate has a weight-average molecular weight of 10,000-200,000 Da and a degree of esterification of 60%-80%.

[0014] Furthermore, the weight-average molecular weight of the polyethylene glycol is 8000-10000 Da.

[0015] The present invention also provides a method for preparing the anti-adhesion hydrophilic coating as described in any one of the above claims, comprising the following steps: (1) Dissolve 10-20 parts by weight of polyurethane in 100-200 parts by weight of butanone at a temperature of 50-70℃ to obtain a first polymer solution. (2) Add 1-5 parts by weight of anatase titanium dioxide and 0.01-0.1 parts by weight of 2-hydroxy-4-methoxybenzophenone to 50-100 parts by weight of butanone, and ultrasonically disperse under ice-water bath conditions to obtain a photocatalyst dispersion. (3) The photocatalyst dispersion is added to the first polymer solution, and 0.1-0.5 parts by weight of γ-methacryloyloxypropyltrimethoxysilane and 0.5-3 parts by weight of isophorone diisocyanate are added and stirred to obtain the first coating composition; (4) Dissolve 5-15 parts by weight of polysulfobetaine methacrylate in 100-200 parts by weight of anhydrous ethanol to obtain a second polymer solution. (5) Add 0.5-3 parts by weight of polyethylene glycol to the second polymer solution and stir to obtain the second coating composition.

[0016] Furthermore, in step (1), the stirring speed is 300-500 rpm.

[0017] Furthermore, in step (2), the rotation speed of the ultrasonic dispersion is 800-1200 rpm.

[0018] Furthermore, in step (2), the ultrasonic dispersion time is 30-50 min.

[0019] Furthermore, in step (3), the stirring temperature is 23-27°C.

[0020] Furthermore, in step (3), the stirring speed is 200-400 rpm.

[0021] Furthermore, in step (3), the stirring time is 60-120 min.

[0022] Furthermore, in step (4), the stirring speed is 200-300 rpm.

[0023] Furthermore, in step (5), the stirring speed is 100-200 rpm.

[0024] Furthermore, in step (5), the stirring time is 30-60 min.

[0025] Furthermore, in step (5), the stirring temperature is 23-27°C.

[0026] Furthermore, step (3) after stirring also includes a vacuum degassing step, wherein the vacuum degree of the vacuum degassing is -0.08 to -0.1 MPa and the time is 10-20 min.

[0027] Furthermore, step (5) after stirring also includes a vacuum degassing step, wherein the vacuum degree of the vacuum degassing is -0.08 to -0.1 MPa and the time is 10-20 min.

[0028] The present invention also provides the application of the anti-adhesion hydrophilic coating described in any one of the above claims or the anti-adhesion hydrophilic coating prepared by any one of the above claims in vascular interventional products.

[0029] The present invention also provides a construction process for using the anti-adhesion hydrophilic coating or the anti-adhesion hydrophilic coating prepared by any of the above-described methods as an anti-adhesion hydrophilic coating, comprising the following steps: (1) Applying the base layer: Apply the first coating composition to the surface of the substrate at a dip-coating speed of 1-10 mm / s; (2) Pre-drying: Pre-dry the coated substrate at 60-80℃; (3) Curing of the base layer: Use 10-30mW / cm² of ultraviolet light to cure the pre-dried base layer for 60-300s; (4) Applying the top layer: Apply the second coating composition to the cured bottom layer surface, with a dip-coating speed of 1-10 mm / s; (5) Top layer curing: Use 5-20mW / cm² UV light to cure the top layer for 300-600s.

[0030] Furthermore, in step (2), the pre-drying time is 5-15 min.

[0031] Furthermore, in step (3), the wavelength of the ultraviolet light is 365nm.

[0032] Furthermore, in step (3), the ultraviolet curing is carried out under an inert atmosphere, the flow rate of which is 0.5L / min-2L / min.

[0033] Furthermore, in step (5), the ultraviolet curing is carried out under the protection of an inert atmosphere, the flow rate of which is 0.5L / min-2L / min.

[0034] Furthermore, after curing in step (5), a post-treatment step is included, which is an aging treatment in hot air at 50-70°C for 2-4 hours.

[0035] The present invention also provides a vascular interventional product, including a device body and an anti-adhesion hydrophilic coating formed by the above-described construction process.

[0036] Furthermore, the device body is a guidewire, microcatheter, or central venous catheter made of polyether block amide, polyurethane, or Pebax material.

[0037] Furthermore, the material of the device body is polyether block polyamide or polyurethane.

[0038] Compared with the prior art, the present invention has the following advantages and beneficial effects: (1) The present invention achieves the unity of ultra-low friction and ultra-strong adhesion in a coating system by using a double-layer structure design, with the bottom layer forming a strong chemical bond with the substrate and the top layer constructing a super-hydrophilic lubricating interface.

[0039] (2) The bottom layer of this invention constructs a highly efficient photocatalytic bonding system through the synergistic effect of anatase titanium dioxide, photosensitizer, polyurethane, isophorone diisocyanate, and silane coupling agent. Under ultraviolet light irradiation, this system can form strong chemical bonds at the interface between the bottom and top layers. This chemical bonding mechanism endows the coating with excellent durability, effectively resisting repeated friction and fluid erosion in complex vascular environments, and avoiding the risk of coating peeling.

[0040] (3) The top layer of this invention uses polysulfobetaine methacrylate and polyethylene glycol, which form a stable hydration lubricating layer through their strong hydration effect, making the water contact angle of the coating surface less than 10° and the dynamic friction coefficient as low as 0.03. At the same time, the zwitterionic polymer endows the coating with excellent anti-protein adhesion ability through charge repulsion and steric hindrance effect, which is of great clinical significance for preventing thrombosis and reducing the pushing resistance of the device in the blood vessel.

[0041] (4) The present invention avoids the migration of components such as isophorone diisocyanate, which may pose a biocompatibility risk, into body fluids through a double-layer structure design, thus having extremely high safety. Detailed Implementation

[0042] The following examples further illustrate specific implementations of the present invention, but the implementation and protection of the present invention are not limited thereto. It should be noted that any processes not specifically described below are those that can be implemented or understood by those skilled in the art by referring to existing technology. Reagents or instruments whose manufacturers are not specified are considered to be conventional products that can be purchased commercially.

[0043] Example 1

[0044] Anti-adhesion hydrophilic coatings include: First coating composition (base layer): by weight, weigh 3 parts of anatase titanium dioxide (average particle size 20nm, specific surface area 100m² / g), 0.05 parts of 2-hydroxy-4-methoxybenzophenone, 15 parts of polyurethane (weight average molecular weight 200000Da), 1.5 parts of isophorone diisocyanate, 0.3 parts of γ-methacryloyloxypropyltrimethoxysilane, and 200 parts of butanone.

[0045] Second coating composition (top layer): By weight, weigh 10 parts of polysulfobetaine methacrylate (weight average molecular weight 50000 Da, degree of esterification 70%), 1.5 parts of polyethylene glycol (weight average molecular weight 9000 Da), and 150 parts of anhydrous ethanol.

[0046] Coating preparation method

[0047] Step (1): Dissolve 15 parts of polyurethane in 200 parts of butanone at 60°C and 400 rpm to obtain the first polymer solution.

[0048] Step (2): Add 3 parts of anatase titanium dioxide and 0.05 parts of 2-hydroxy-4-methoxybenzophenone to 75 parts of butanone, and ultrasonically disperse at 1000 rpm for 40 minutes under ice-water bath conditions to obtain a photocatalyst dispersion.

[0049] Step (3): Add the photocatalyst dispersion to the first polymer solution, add 0.3 parts of γ-methacryloxypropyltrimethoxysilane and 1.5 parts of isophorone diisocyanate, and stir at 300 rpm for 90 minutes at 25°C to obtain the first coating composition.

[0050] Step (4): Dissolve 10 parts of polysulfobetaine methacrylate in 150 parts of anhydrous ethanol at 25°C and 250 rpm to obtain a second polymer solution.

[0051] Step (5): Add 1.5 parts of polyethylene glycol to the second polymer solution and stir at 150 rpm for 45 minutes at 25°C to obtain the second coating composition.

[0052] Step (6): Degas the first coating composition obtained in step (3) and the second coating composition obtained in step (5) under vacuum at -0.09 MPa for 15 minutes, and set aside.

[0053] Coating application process

[0054] Step (1): The first coating composition is applied to the cleaned and dried Pebax guide wire surface by dip coating at a dip coating speed of 5 mm / s.

[0055] Step (2): Pre-dry the coated guide wire in an oven at 70°C for 10 minutes.

[0056] Step (3): Under nitrogen protection (flow rate 1L / min), use ultraviolet light with a wavelength of 365nm and a light intensity of 20mW / cm² to cure the pre-dried substrate for 180 seconds.

[0057] Step (4): Apply the second coating composition to the cured substrate surface using a dip coating method at a dip coating speed of 5 mm / s.

[0058] Step (5): Under nitrogen protection (flow rate 1L / min), the top layer is cured for 450 seconds using ultraviolet light with a wavelength of 365nm and a light intensity of 12.5mW / cm².

[0059] Step (6): The cured guide wire is aged in hot air at 60°C for 3 hours to obtain the finished product.

[0060] Example 2

[0061] The difference between this embodiment and the previous embodiment is that the anatase titanium dioxide is anatase titanium dioxide coated with silicon dioxide, and the thickness of the silicon dioxide coating layer is 2nm.

[0062] Example 3

[0063] The difference between this embodiment and Embodiment 1 is that the anti-adhesion hydrophilic coating includes: The first coating composition consists of 5 parts anatase titanium dioxide, 20 parts polyurethane, 3 parts isophorone diisocyanate, and 300 parts methyl ethyl ketone.

[0064] The second coating composition consists of 15 parts of polysulfobetaine methacrylate, 3 parts of polyethylene glycol, and 200 parts of anhydrous ethanol.

[0065] Example 4

[0066] The difference between this embodiment and Embodiment 1 is that the anatase titanium dioxide is anatase titanium dioxide with silver nanoparticles loaded on its surface, wherein the silver loading is 0.5 wt%.

[0067] Example 5

[0068] The difference between this embodiment and Example 1 is that the degree of esterification of polysulfobetaine methacrylate is 60%.

[0069] Comparative Example 1

[0070] The difference between this comparative example and the embodiment is that the first coating composition does not contain anatase titanium dioxide and 2-hydroxy-4-methoxybenzophenone.

[0071] Comparative Example 2

[0072] The difference between this comparative example and Example 1 is that a single-layer coating is used. All solid components of the first and second compositions in Example 1 are mixed in a mixed solvent of butanone / ethanol (volume ratio 1:1) to form a single coating.

[0073] Then, follow these steps to spray and cure the single coating onto the Pebax guidewire surface: (1) Apply a single coating to the surface of the Pebax guidewire using the dip coating method at a dip coating speed of 5 mm / s; (2) Cure the top layer for 450 seconds under nitrogen protection (flow rate 1 L / min) with ultraviolet light at a wavelength of 365 nm and a light intensity of 12.5 mW / cm²; (3) Age the cured guidewire in hot air at 60°C for 3 hours.

[0074] Comparative Example 3

[0075] The difference between this comparative example and Example 1 is that the first coating composition does not contain γ-methacryloyloxypropyltrimethoxysilane.

[0076] Comparative Example 4

[0077] The difference between this comparative example and Example 1 is that the first coating composition does not contain 2-hydroxy-4-methoxybenzophenone.

[0078] Comparative Example 5

[0079] The difference between this comparative example and Example 1 is that the first coating composition does not contain isophorone diisocyanate.

[0080] Comparative Example 6

[0081] The difference between this comparative example and the embodiment is that only the first coating composition is used to form the underlayer, and no top layer is coated.

[0082] Comparative Example 7

[0083] The difference between this comparative example and Example 1 is that only the second coating composition is used to form the top layer, and the bottom layer is not coated.

[0084] Comparative Example 8

[0085] The difference between this comparative example and Example 1 is that the degree of esterification of the polysulfonated betaine methacrylate is 30%.

[0086] Comparative Example 9

[0087] The difference between this comparative example and Example 1 is that the dip-coating speed is 20 mm / s in the construction process.

[0088] Comparative Example 10

[0089] The difference between this comparative example and Example 1 is that in the construction process, the bottom layer is cured with 50mW / cm² UV light for 30 seconds, and the top layer is cured with 40mW / cm² UV light for 60 seconds.

[0090] Effect verification: (1) Cytotoxicity test Blank control group: cell wells with only fresh culture medium added.

[0091] Sample preparation for the experimental group (extraction method): After sterilization, the coating samples from each example and comparative example were placed in sterile glass containers. MEM culture medium was added at a surface area to volume ratio of 3 cm² / mL. The containers were then placed in a constant temperature incubator at 37°C and allowed to stand for 24 hours to extract the sample extract.

[0092] Experimental steps: L929 cells in logarithmic growth phase were digested with trypsin, and the cell suspension density was adjusted to 1×10⁻⁶. 4 Cells / mL were seeded into 96-well plates at 100 μL per well using MEM medium containing 10% fetal bovine serum (FBS). The plates were incubated at 37°C with 5% CO2 for 24 hours to allow cell adhesion. The original medium was discarded, and 100 μL of sample extract or fresh medium (for a blank control group) was added to each well. Incubation continued for another 24 hours. 20 μL of MTT solution (5 mg / mL) was added to each well, and incubation continued for another 4 hours. The supernatant was discarded, and 150 μL of dimethyl sulfoxide (DMSO) was added to each well. The plates were shaken for 10 minutes to fully dissolve the blue-purple formazan crystals. The absorbance (OD value) of each well was measured using a microplate reader at 570 nm.

[0093] Relative cell proliferation rate (RGR) (%) = (OD value of experimental group / OD value of blank control group) × 100%

[0094] (2) Hemolytic test

[0095] Blank control group: physiological saline.

[0096] Positive control group: deionized water.

[0097] Sample preparation for the experimental group: 0.2g of each coating sample from the examples and comparative examples was accurately weighed and placed in a test tube.

[0098] Experimental steps: Add 10 mL of physiological saline to the blank control tube, 10 mL of deionized water to the positive control tube, and 10 mL of diluted anticoagulated rabbit blood (physiological saline: rabbit blood = 7:3) to each experimental sample tube. Incubate all tubes in a 37°C water bath for 1 hour. After incubation, centrifuge all tubes at 1500 rpm for 10 minutes. Collect the supernatant from each tube and measure its absorbance (OD value) at 545 nm using a spectrophotometer.

[0099] Hemolysis rate (%) = [(OD value of experimental group - OD value of blank control group) / (OD value of positive control group - OD value of blank control group)] × 100%

[0100] (3) Dynamic friction coefficient test

[0101] Experimental conditions: Environment: 37℃ simulated body fluid (PBS solution) environment.

[0102] Friction component: Medical-grade 316L stainless steel ball with a diameter of 6mm.

[0103] Load: 100g.

[0104] Sliding speed: 10mm / s.

[0105] Blank control group: Substrate samples of the same material and size as those in the examples, without any coating.

[0106] Experimental group: Finished products from each embodiment.

[0107] Experimental steps: The finished products and blank control group samples from each embodiment were fixed on the sample stage of a pin-disc friction and wear testing machine. PBS solution was dropped onto the sample surface to completely wet it. The testing machine was started, and a stainless steel ball was slid back and forth on the sample surface. The dynamic friction coefficient was calculated.

[0108] (4) Measurement of water contact angle

[0109] Experimental instrument: Optical contact angle measuring instrument.

[0110] Experimental conditions: room temperature (25℃), relative humidity (50±5%).

[0111] Blank control group: Substrate samples of the same material as those in the examples, without any coating.

[0112] Experimental group: Finished products from each embodiment.

[0113] Experimental steps: Place the finished products and blank control group samples of each embodiment flat on the sample stage. Using a microsyringe, gently drop 2 μL of deionized water onto the sample surface. Calculate the static water contact angle. Measure at at least 5 different locations for each sample and take the average value as the final result.

[0114] (5) Protein adhesion test

[0115] Experimental materials: Protein solution: 1 mg / mL bovine serum albumin (BSA) phosphate buffer.

[0116] Eluent: 1% (w / v) aqueous solution of sodium dodecyl sulfate (SDS).

[0117] Test reagent: BCA kit (BCA1-1KT, Merck).

[0118] Control group: Blank control group: Substrate samples of the same material as those in the examples, without any coating.

[0119] Experimental group: Finished products from each embodiment.

[0120] Experimental steps: Immerse the finished product samples (1cm × 1cm) and blank control samples from each example into 1mL of BSA solution. Incubate in a 37°C water bath for 2 hours. Remove the samples and gently rinse three times with PBS to remove unadhered free proteins. Immerse the rinsed samples in 1mL of SDS elution buffer and shake at 37°C for 30 minutes to elute the adhered proteins. Collect the eluent and add BCA working solution according to the BCA kit instructions. After incubation at 37°C for 30 minutes, measure the absorbance at 562nm using a microplate reader. Calculate the protein concentration in the eluent based on the BSA standard curve and then convert it to the amount of protein adhered per unit area.

[0121] Table 1. Summary of efficacy verification results for the examples, comparative examples, and blank control group.

[0122] Comprehensive experimental results show that the anti-adhesion hydrophilic coating provided by this invention exhibits excellent performance in all aspects. All embodiments demonstrate excellent biocompatibility and blood compatibility. Simultaneously, the dynamic coefficient of friction in all embodiments is below 0.05, the water contact angle is less than 10°, and the protein adhesion is extremely low, possessing super-lubricating, super-hydrophilic, and strong anti-adhesion properties. Example 2 shows improved performance compared to Example 1. This is because silica coating improves the dispersion of nanoparticles in the polymer, making their distribution more uniform in the bottom layer, resulting in more and more effective bonding points with the top layer. Example 4 maintains excellent basic performance while significantly reducing protein adhesion (6.5 μg / cm²), indicating that the silver nanoparticles loaded in the bottom layer endow the coating with excellent antibacterial ability, effectively inhibiting the formation of initial protein biofilms. The performance comparison between Example 5 and Comparative Example 8 clearly shows that the degree of esterification of polysulfobetaine methacrylate is key to affecting hydrophilic lubrication performance. If the esterification level is too low, the polymer chain becomes too rigid, making it difficult to form an effective hydration layer, which leads to a sharp decline in hydrophilicity, lubricity, and anti-adhesion.

[0123] Comparative Example 2 showed poor performance in all aspects, with even cytotoxicity <70%. This may be due to the interference between functional components caused by monolayer mixing, the catalyst being embedded and ineffective, and the leaching of unreacted small molecules such as isocyanates leading to cytotoxicity.

[0124] The performance of Comparative Examples 3 and 4 was significantly reduced. This indicates that the lack of a coupling agent prevented molecular coupling between the inorganic catalyst and the organic polymer layer; the lack of a photosensitizer prevented effective photocatalytic bonding. Both factors resulted in weak bonding of the top layer, making it prone to failure under friction or liquid washing.

[0125] Comparative Example 5 shows that the cross-linked network formed by polyurethane and isophorone diisocyanate is the basis for the mechanical strength of the underlying layer.

[0126] The performance of Comparative Examples 6 and 7 was also inferior to that of the Example. Although Comparative Example 6 had a bottom layer, its surface was hydrophobic and it did not have a lubricating function; although Comparative Example 7 had a hydrophilic top layer, its adhesion to the substrate was poor, its performance was unstable, and its anti-adhesion ability was limited.

[0127] Comparative Examples 9 and 10 show that excessively fast lifting speeds can lead to excessively thick and uneven coatings; improper curing conditions can lead to excessive internal stress or incomplete cross-linking, both of which will impair the final performance of the coating.

[0128] The above embodiments are merely preferred embodiments of the present invention and are only used to explain the present invention, not to limit the present invention. Any changes, substitutions, modifications, etc., made by those skilled in the art without departing from the spirit and essence of the present invention should be within the protection scope of the present invention.

Claims

1. An anti-adhesion hydrophilic coating, characterized in that, It includes a first coating composition for forming the underlayer and a second coating composition for forming the top layer; The first coating composition comprises, by weight, the following components: 1-5 parts anatase titanium dioxide, 0.01-0.1 parts 2-hydroxy-4-methoxybenzophenone, 10-20 parts polyurethane, 0.5-3 parts isophorone diisocyanate, 0.1-0.5 parts γ-methacryloyloxypropyltrimethoxysilane and 150-300 parts butanone; The second coating composition comprises, by weight, the following components: 5-15 parts polysulfobetaine methacrylate, 0.5-3 parts polyethylene glycol and 100-200 parts anhydrous ethanol.

2. The anti-adhesion hydrophilic coating according to claim 1, characterized in that, The anatase titanium dioxide is surface-modified anatase titanium dioxide.

3. The anti-adhesion hydrophilic coating according to claim 2, characterized in that, The surface-modified anatase titanium dioxide is anatase titanium dioxide coated with silica, and the thickness of the silica coating layer is 1-3 nm.

4. The anti-adhesion hydrophilic coating according to claim 2, characterized in that, The surface-modified anatase titanium dioxide is anatase titanium dioxide with silver nanoparticles loaded on its surface, wherein the silver loading is 0.1-1 wt%.

5. The anti-adhesion hydrophilic coating according to claim 1, characterized in that, The anatase titanium dioxide has an average particle size of 5-50 nm and a specific surface area of ​​50-200 m² / g; the mass ratio of the polyurethane to the isophorone diisocyanate is 100:5-100:15; the weight-average molecular weight of the polyurethane is 50,000-500,000 Da; and the weight-average molecular weight of the polyethylene glycol is 8,000-10,000 Da.

6. The anti-adhesion hydrophilic coating according to claim 1, characterized in that, The polysulfonated betaine methacrylate has a weight-average molecular weight of 10,000-200,000 Da and a degree of esterification of 60%-80%.

7. The method for preparing the anti-adhesion hydrophilic coating according to any one of claims 1-6, characterized in that, Includes the following steps: (1) Dissolve 10-20 parts by weight of polyurethane in 100-200 parts by weight of butanone at a temperature of 50-70℃ to obtain a first polymer solution. (2) Add 1-5 parts by weight of anatase titanium dioxide and 0.01-0.1 parts by weight of 2-hydroxy-4-methoxybenzophenone to 50-100 parts by weight of butanone, and ultrasonically disperse under ice-water bath conditions to obtain a photocatalyst dispersion. (3) The photocatalyst dispersion is added to the first polymer solution, and 0.1-0.5 parts by weight of γ-methacryloyloxypropyltrimethoxysilane and 0.5-3 parts by weight of isophorone diisocyanate are added and stirred to obtain the first coating composition; (4) Dissolve 5-15 parts by weight of polysulfobetaine methacrylate in 100-200 parts by weight of anhydrous ethanol to obtain a second polymer solution. (5) Add 0.5-3 parts by weight of polyethylene glycol to the second polymer solution and stir to obtain the second coating composition.

8. The application of the anti-adhesion hydrophilic coating according to any one of claims 1-6 or the anti-adhesion hydrophilic coating prepared by the preparation method according to claim 7 in vascular interventional products.

9. The application process of the anti-adhesion hydrophilic coating according to any one of claims 1-6 or the anti-adhesion hydrophilic coating prepared by the preparation method according to claim 7 as an anti-adhesion hydrophilic coating is characterized in that, Includes the following steps: (1) Applying the base layer: Apply the first coating composition to the surface of the substrate at a dip-coating speed of 1-10 mm / s; (2) Pre-drying: Pre-dry the coated substrate at 60-80℃; (3) Curing of the base layer: Use 10-30mW / cm² of ultraviolet light to cure the pre-dried base layer for 60-300s; (4) Applying the top layer: Apply the second coating composition to the cured bottom layer surface, with a dip-coating speed of 1-10 mm / s; (5) Top layer curing: Use 5-20mW / cm² UV light to cure the top layer for 300-600s.

10. A vascular interventional product comprising a device body and an anti-adhesion hydrophilic coating formed by the construction process described in claim 9.

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