Manufacturing equipment for manufacturing pharmaceutical preparation

Abstract

The invention provides manufacturing equipment for manufacturing a pharmaceutical preparation. The manufacturing equipment comprises a material mixing and granulating assembly, a vacuum rotary drying assembly and a tablet press, and the vacuum rotary drying assembly is located between the material mixing and granulating assembly and the tablet press; the vacuum rotary drying assembly comprises a double-cone-shaped cylinder, a vacuum mechanism, a heating suite, two opposite rotating rods and two opposite fixing columns. A filter cover is arranged between the tail end of the rotating rod with the cavity and the inner side wall of the double-cone-shaped cylinder, and filter elements which are arranged in an inclined radial shape are arranged in the filter cover; the vacuum rotary drying assembly adopts a vacuum drying technology, and the right-angled trapezoid heat transfer material turning plates arranged on the inner wall of the double-cone-shaped cylinder in the generatrix direction continuously turn over particles in the rotating process, so that the particles are uniformly dried, and the particles are uniformly dried. The problem that particles are locally overheated or dried unevenly in traditional drying equipment is solved, the drying quality is improved, and it is ensured that each particle can reach the needed drying degree.

Description

Technical Field

[0001] This invention relates to the field of biopharmaceutical manufacturing technology, and in particular to a manufacturing apparatus for manufacturing pharmaceutical preparations. Background Technology

[0002] Niacin tablets are one of the essential B vitamins for the human body, mainly used to prevent or treat niacin deficiency and to help regulate blood lipids. In the field of niacin tablet pharmaceutical manufacturing, the drying process is one of the key steps to ensure the quality and stability of the drug. Suitable drying equipment can accurately remove moisture from raw materials or preparations, preventing problems such as deterioration, clumping, and microbial growth in drugs during storage and use due to improper moisture content, thereby ensuring the efficacy and safety of the drug.

[0003] Existing vacuum rotary drying equipment mainly consists of a double-cone cylinder, a vacuum system, a heating system, and a transmission system. The double-cone cylinder, serving as the container for the particles to be dried, typically has conical ends. This design facilitates the tumbling and discharge of materials within the cylinder. The vacuum system primarily comprises a vacuum pump and an extraction pipe. The vacuum pump is connected to the double-cone cylinder via the extraction pipe, and its function is to extract air from the cylinder during the drying process, creating a vacuum environment. Currently, although the double-cone cylinder can rotate, the particles primarily rely on their own rolling and mutual friction to change position and contact surface during the drying process. This tumbling method is not sufficient or uniform, causing some particles to remain in the same position for extended periods, resulting in insufficient heat contact with the heating system. This can easily lead to localized overheating or uneven drying. Locally overheated particles may deteriorate or scorch, affecting the quality of the medicine. Unevenly dried particles may result in inconsistent moisture content throughout the batch of medicine, leading to stratification and clumping during storage, reducing the stability of the medicine.

[0004] Therefore, it is necessary to provide a new manufacturing equipment for manufacturing pharmaceutical preparations to solve the above-mentioned technical problems. Summary of the Invention

[0005] To address the aforementioned technical problems, the present invention provides a manufacturing apparatus for manufacturing pharmaceutical preparations.

[0006] The manufacturing equipment for manufacturing pharmaceutical preparations provided by the present invention includes a mixing and granulation assembly, a vacuum rotary drying assembly, and a tablet press, wherein the vacuum rotary drying assembly is located between the mixing and granulation assembly and the tablet press. The vacuum rotary drying assembly includes a double-cone cylinder, a vacuum mechanism, a heating kit, two opposing rotating rods, and two opposing fixed columns. The two sides of the double-cone cylinder are fixedly connected to the two rotating rods respectively. The top and bottom ends of the double-cone cylinder are respectively provided with a feed inlet and a discharge outlet. The feed inlet is provided with a cover, and the discharge outlet is provided with a discharge valve. The two rotating rods are rotatably mounted on the two fixed columns respectively, and the inner cavity of one of the rotating rods is connected to both the vacuum mechanism and the inner cavity of the double-cone cylinder. The heating kit is sleeved on the outer wall of the double-cone cylinder. One of the fixed columns is also provided with a drive mechanism for rotating the rotating rod. A filter cover is provided between the end of the hollow rotating rod and the inner wall of the double-conical cylinder, and the filter cover is provided with filter elements arranged in an oblique radial pattern. The inner wall of the double-cone cylinder is provided with several right-angled trapezoidal heat transfer turning plates along the generatrix direction.

[0007] Furthermore, the mixing and granulation assembly includes a mixing cylinder, a stirring rod, a stirring motor, a feed pipe, an air supply pipe, an air pump, and a granulation mechanism. The mixing cylinder is fixedly installed at the input end of the granulation mechanism. The bottom of the mixing cylinder is provided with a discharge pipe connected to the input end of the granulation mechanism, and a discharge valve is provided on the discharge pipe. The stirring motor is fixedly installed at the top of the mixing cylinder, and the output end of the stirring motor is fixedly connected to one end of the stirring rod. The bottom of the stirring rod is located inside the mixing cylinder. A side wall scraper is also provided on the inner side of the mixing cylinder. A drive cylinder for driving the side wall scraper to move up and down is provided at the top of the mixing cylinder. The feed pipe is connected to the inner cavity of the mixing cylinder. The air supply pipe is laterally connected to the feed pipe. An air-closing valve is provided on the top of the feed pipe adjacent to the air supply pipe. The output end of the air pump is fixedly connected to one end of the air supply pipe.

[0008] Furthermore, the tablet press includes a frame, a pressing block, a fixed base, a forming plate, a top block, a first thrust cylinder, and a second thrust cylinder. The first thrust cylinder is fixedly installed on the top of the frame, and its output end is fixedly connected to the top of the pressing block. The bottom of the pressing block is provided with multiple pressing pins. The fixed base is fixedly installed on one side of the frame. The forming plate is fixedly installed on the top of the fixed base and is provided with multiple forming grooves. The second thrust cylinder is fixedly installed on the fixed base, and its output end is fixedly connected to the top block. The top of the top block is provided with multiple ejector pins. The forming plate is also provided with a pushing mechanism for pushing the dried formulation granules into the forming grooves. The ejector pin, the forming groove, and the pressure pin are positioned correspondingly, and the forming groove is located between the ejector pin and the pressure pin.

[0009] Furthermore, the vacuum mechanism includes a vacuum pump and a suction pipe. The vacuum pump is located on one side of the fixed column. The output end of the vacuum pump is fixedly connected to one end of the suction pipe, and the other end of the suction pipe is rotatably connected to the rotating rod with a cavity. The suction pipe communicates with the inner cavity of the rotating rod.

[0010] Furthermore, the heating kit includes a heat-conducting sleeve and an electric heater. The heat-conducting sleeve is fixedly installed on the outside of the double-conical cylinder, and the electric heater is fixedly installed inside the heat-conducting sleeve.

[0011] Furthermore, the driving mechanism includes a drive motor, two opposing sprockets, and a chain. The drive motor is fixedly installed on the inner side wall of the fixed column, and a shaft is fixedly connected to the output end of the drive motor. The two sprockets are respectively fixedly installed on the shaft and the surface of the rotating rod, and the two sprockets are connected by the chain.

[0012] Furthermore, the granulation mechanism includes a fixed frame, a granulation cylinder with holes, a pressure roller, a granulation disc, a rotating rod, and a geared motor for driving the rotating rod to rotate. The granulation cylinder is fixedly installed on the fixed frame, and the top of the granulation cylinder is connected to the inner cavity of the feed pipe. The rotating rod is rotatably installed on the fixed frame. The geared motor is fixedly installed on the fixed frame, and the output end of the geared motor is fixedly connected to one end of the rotating rod. One end of the rotating rod is fixedly connected to the bottom of the granulation disc. The pressure roller is rotatably installed inside the granulation cylinder, and the pressure roller is located above the granulation disc. A granulation outlet is opened on the side of the granulation cylinder adjacent to the bottom of the granulation disc.

[0013] Furthermore, the feeding mechanism includes a mounting base, a feeding electric cylinder, a feeding frame, and two opposing guide rods. The mounting base is fixedly mounted on the forming plate, the feeding electric cylinder is fixedly mounted on the mounting base, the output end of the feeding electric cylinder is fixedly connected to one side of the feeding frame, the two guide rods are respectively fixedly mounted on both ends of the mounting base, the two sides of the feeding frame are respectively slidably mounted on the two guide rods, and the feeding frame is provided with multiple partition plates.

[0014] Furthermore, a push plate is provided on one side of the feeding frame, and a discharge groove is provided on one side of the forming plate, with the discharge groove corresponding to the position of the push plate.

[0015] Furthermore, the method for manufacturing nicotinic acid tablets using the aforementioned preparation equipment includes the following steps: Step 1: Raw material mixing and granulation: Weigh out nicotinic acid, lactose, hydroxypropyl methylcellulose and glycerin excipients according to the prescription ratio, and add them into the mixing cylinder through the feed pipe. Start the stirring motor to make the stirring rod rotate. During the mixing process, add an appropriate amount of binder. At the same time, drive the electric cylinder to drive the side wall scraper to move up and down to scrape off the raw materials adhering to the inner wall of the mixing cylinder, ensuring that the raw materials are mixed evenly. After mixing for a period of time, open the air-closing valve and start the air pump to blow air into the feed pipe through the air supply pipe to blow the residual raw materials into the mixing cylinder. Then open the discharge valve to let the mixed raw materials enter the granulation cylinder through the discharge pipe. Start the reduction motor to drive the rotating rod and granulation disc to rotate. The pressure roller squeezes the raw materials on the granulation disc to make wet granules of uniform size. Step 2, Particle Drying: Open the cover on the feed port of the vacuum rotary dryer and add the prepared nicotinic acid wet particles into the double-cone cylinder through the feed port. Then close the cover, start the vacuum pump, and extract the air from the double-cone cylinder through the air extraction pipe to create a vacuum environment for vacuum drying. During the drying process, the pressure inside the cylinder is always lower than the atmospheric pressure. Turn on the electric heater and heat the double-cone cylinder through the heat-conducting jacket. At the same time, start the drive motor and drive the rotating rod and double-cone cylinder to rotate through the sprocket and chain. The right-angle trapezoidal heat transfer turning plate turns the particles to ensure that the particles are heated evenly for drying. After drying for a period of time, turn off the vacuum pump, electric heater and drive motor, and open the discharge valve to discharge the dried nicotinic acid particles. Step 3, tableting: Add the dried granules to magnesium stearate lubricant, mix well, and then push them into the forming groove of the forming plate through the feeding frame of the pushing mechanism. Start the first thrust cylinder to push the pressing block downward. The pressing pin at the bottom of the pressing block presses the granules in the forming groove into nicotinic acid tablets. Start the second thrust cylinder to push the top block upward. The ejector pin at the top of the top block ejects the pressed nicotinic acid tablets in the forming groove. The nicotinic acid tablets are discharged through the feeding chute, completing the manufacturing of nicotinic acid tablets.

[0016] Compared with related technologies, the manufacturing equipment for manufacturing pharmaceutical preparations provided by the present invention has the following beneficial effects: 1. The vacuum rotary drying assembly of this invention adopts vacuum drying technology. During the drying process, the vacuum pump extracts air from the double-cone cylinder through the air extraction pipe to form a vacuum environment. Under vacuum conditions, the boiling point of water decreases, and the moisture in the particles evaporates more easily, thereby greatly improving the drying efficiency. At the same time, the vacuum environment can also effectively prevent adverse reactions such as oxidation and deterioration of the particles during the drying process, ensuring the quality and stability of the medicine. The double-cone cylinder rotates under the drive mechanism. The right-angled trapezoidal heat transfer turning plate set along the generatrix direction on the inner wall continuously turns the particles during the rotation, so that the particles can continuously change their position and contact surface during the drying process, and fully contact the heat transferred by the heating kit, achieving uniform heating. This avoids the problem of local overheating or uneven drying of particles in traditional drying equipment, improves the drying quality, and ensures that each particle reaches the required degree of dryness.

[0017] 2. In the mixing and granulation assembly of the present invention, the stirring rod and the side wall scraper work together to form an all-round mixing system. While the stirring rod performs conventional stirring of the raw materials, the side wall scraper moves up and down under the drive of the electric cylinder, which can promptly scrape off the raw materials adhering to the inner wall of the mixing cylinder, avoiding local accumulation and residue of raw materials, achieving a highly uniform mixing effect, greatly improving the utilization rate of raw materials, reducing the waste of raw materials caused by uneven mixing, and lowering production costs. When feeding, the air-closing valve is opened and the air pump is started. The airflow enters the feed pipe through the air supply pipe, blowing any residual raw materials into the mixing cylinder, effectively solving the problem of raw material blockage, ensuring that the raw materials can smoothly and completely enter the next process, ensuring the continuity and stability of the production process, and improving the overall production efficiency.

[0018] 3. In order to prevent particles from being extracted from the double-conical cylinder during the vacuuming process, this invention has a filter cover between the end of the rotating rod with a cavity and the inner wall of the double-conical cylinder. The filter cover has filter elements arranged in a diagonally radial pattern inside, which increases the vacuuming area. The vertical installation of the filter cover allows the material to fall naturally under the action of gravity, reducing the accumulation on the filter screen. Compared with the traditional installation method, this is more conducive to ensuring the uniformity of drying, while ensuring the smooth passage of airflow, ensuring the normal operation of the vacuum pump and the stability of the vacuum environment, extending the service life of the equipment, reducing the frequency of equipment failure, and lowering maintenance costs. Attached Figure Description

[0019] Figure 1 A schematic diagram of the overall structure of the manufacturing equipment for manufacturing pharmaceutical preparations provided by the present invention. Figure 1 ; Figure 2 A schematic diagram of the overall structure of the manufacturing equipment for manufacturing pharmaceutical preparations provided by the present invention. Figure 2 ; Figure 3 A cross-sectional view of the vacuum rotary drying assembly provided by the present invention; Figure 4 for Figure 3 The enlarged structural diagram at point A is shown below; Figure 5 A cross-sectional view of the mixing and granulation assembly provided by the present invention; Figure 6 for Figure 5 The enlarged structural diagram at point B is shown below; Figure 7 for Figure 5 The enlarged structural diagram at point C is shown below; Figure 8 A schematic diagram of the tablet press provided by the present invention. Figure 1 ; Figure 9 for Figure 8 The diagram shows an enlarged view of the structure at point D. Figure 10 A schematic diagram of the tablet press provided by the present invention. Figure 2 ; Figure 11 A flowchart illustrating the process of manufacturing nicotinic acid tablets using the preparation equipment provided by this invention.

[0020] The following are the labels in the diagram: 1. Double-cone cylinder; 2. Rotating rod; 3. Fixed column; 4. Feed inlet; 5. Discharge outlet; 6. Cover; 7. Filter cover; 8. Filter element; 9. Heat transfer turning plate; 10. Mixing cylinder; 11. Stirring rod; 12. Stirring motor; 13. Feed pipe; 14. Air supply pipe; 15. Air pump; 16. Discharge pipe; 17. Side wall scraper; 18. Drive cylinder; 19. Frame; 20. Press block; 21. Fixed base; 22. Forming plate; 23. Top block; 24. Thrust cylinder one; 25. Thrust cylinder II; 26. Pressing pin; 27. Forming channel; 28. Ejector pin; 29. ​​Vacuum pump; 30. Evacuation pipe; 31. Heat-conducting sleeve; 32. Drive motor; 33. Sprocket; 34. Chain; 35. Fixing frame; 36. Granulation cylinder; 37. Pressure roller; 38. Granulation disc; 39. Rotating rod; 40. Gear motor; 41. Granulation outlet; 42. Mounting base; 43. Pushing cylinder; 44. Feeding frame; 45. Guide rod; 46. Divider plate; 47. Push plate; 48. Discharge chute. Detailed Implementation

[0021] The present invention will be further described below with reference to the accompanying drawings and embodiments.

[0022] Please refer to the following: Figures 1-11 ,in, Figure 1 A schematic diagram of the overall structure of the manufacturing equipment for manufacturing pharmaceutical preparations provided by the present invention. Figure 1 ; Figure 2A schematic diagram of the overall structure of the manufacturing equipment for manufacturing pharmaceutical preparations provided by the present invention. Figure 2 ; Figure 3 A cross-sectional view of the vacuum rotary drying assembly provided by the present invention; Figure 4 for Figure 3 The enlarged structural diagram at point A is shown below; Figure 5 A cross-sectional view of the mixing and granulation assembly provided by the present invention; Figure 6 for Figure 5 The enlarged structural diagram at point B is shown below; Figure 7 for Figure 5 The enlarged structural diagram at point C is shown below; Figure 8 A schematic diagram of the tablet press provided by the present invention. Figure 1 ; Figure 9 for Figure 8 The diagram shows an enlarged view of the structure at point D. Figure 10 A schematic diagram of the tablet press provided by the present invention. Figure 2 ; Figure 11 A flowchart illustrating the process of manufacturing nicotinic acid tablets using the preparation equipment provided by this invention.

[0023] In the description of this invention, unless otherwise explicitly specified and limited, the terms "connected," "linked," and "fixed" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0024] In the description of this invention, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention. In addition, the terms "first," "second," etc., are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first," "second," etc., may explicitly or implicitly include one or more of that feature. In the description of this invention, unless otherwise stated, "a plurality of" means two or more.

[0025] Example 1 In the specific implementation process, such as Figure 1-10As shown, the manufacturing equipment for manufacturing pharmaceutical formulations includes a mixing and granulation assembly, a vacuum rotary drying assembly, and a tablet press, with the vacuum rotary drying assembly located between the mixing and granulation assembly and the tablet press. The vacuum rotary drying assembly includes a double-cone cylinder 1, a vacuum mechanism, a heating kit, two opposing rotating rods 2, and two opposing fixed columns 3. The two sides of the double-cone cylinder 1 are fixedly connected to the two rotating rods 2 respectively. The top and bottom ends of the double-cone cylinder 1 are respectively provided with a feed port 4 and a discharge port 5. The feed port 4 is provided with a cover 6, and the discharge port 5 is provided with a discharge valve. The two rotating rods 2 are rotatably mounted on the two fixed columns 3 respectively, and the inner cavity of one of the rotating rods 2 is connected to both the vacuum mechanism and the inner cavity of the double-cone cylinder 1. The heating kit is sleeved on the outer wall of the double-cone cylinder 1. One of the fixed columns 3 is also provided with a drive mechanism for driving the rotating rod 2 to rotate. A filter cover 7 is provided between the end of the hollow rotating rod 2 and the inner wall of the double conical cylinder 1, and filter elements 8 arranged obliquely radially are provided inside the filter cover 7. The inner wall of the double-cone cylinder 1 is provided with several right-angled trapezoidal heat transfer turning plates 9 along the generatrix direction.

[0026] It should be noted that the vacuum mechanism includes a vacuum pump 29 and a suction pipe 30. The vacuum pump 29 is located on one side of the fixed column 3. The output end of the vacuum pump 29 is fixedly connected to one end of the suction pipe 30. The other end of the suction pipe 30 is rotatably connected to the rotating rod 2 with a cavity, and the suction pipe 30 is connected to the inner cavity of the rotating rod 2.

[0027] It should be noted that the heating kit includes a heat-conducting sleeve 31 and an electric heater. The heat-conducting sleeve 31 is fixedly installed on the outside of the double-conical cylinder 1, and the electric heater is fixedly installed inside the heat-conducting sleeve 31.

[0028] It should be noted that the drive mechanism includes a drive motor 32, two opposing sprockets 33 and a chain 34. The drive motor 32 is fixedly installed on the inner side wall of the fixed column 3. The output end of the drive motor 32 is fixedly connected to a shaft. The two sprockets 33 are respectively fixedly installed on the shaft and the surface of the rotating rod 2. The two sprockets 33 are connected by the chain 34. During vacuum drying, the cover 6 on the feed port 4 is opened, and the granules produced by the mixing and granulation component are added into the double-cone cylinder 1 through the feed port 4. Then, the cover 6 is closed, and the vacuum pump 29 is started. The vacuum pump 29 is connected to the rotating rod 2 with a cavity through the air extraction pipe 30, thereby extracting the air from the double-cone cylinder 1 to form a vacuum environment. The electric heater works and transfers heat to the double-cone cylinder 1 through the heat-conducting sleeve 31 to heat the granules inside the cylinder. At the same time, the drive motor 32 drives the shaft to rotate, and the shaft drives the rotating rod 2 to rotate through the sprocket 33 and the chain 34. The rotating rod 2 drives the double-cone cylinder 1 to rotate. The right-angled trapezoidal heat transfer turning plate 9 set along the generatrix direction on the inner wall of the double-cone cylinder 1 continuously turns the granules during the rotation, so that the granules are heated evenly and the drying speed is accelerated. During the vacuuming process, the obliquely radially arranged filter elements 8 inside the filter cover 7 can prevent the granules from being extracted from the double-cone cylinder 1. After drying is complete, open the discharge valve and the particles are discharged through discharge port 5.

[0029] In some embodiments, reference is made to Figures 5-7 As shown, the mixing and granulation assembly includes a mixing cylinder 10, a stirring rod 11, a stirring motor 12, a feed pipe 13, an air supply pipe 14, an air pump 15, and a granulation mechanism. The mixing cylinder 10 is fixedly installed at the input end of the granulation mechanism. A discharge pipe 16, connected to the input end of the granulation mechanism, is located at the bottom of the mixing cylinder 10. A discharge valve is provided on the discharge pipe 16. The stirring motor 12 is fixedly installed at the top of the mixing cylinder 10. The output end of the stirring motor 12 is fixedly connected to one end of the stirring rod 11. The bottom of the stirring rod 11 is located inside the mixing cylinder 10. A side wall scraper 17 is also provided on the inner side of the mixing cylinder 10. A drive cylinder 18 for driving the side wall scraper 17 to move up and down is provided at the top of the mixing cylinder 10. The feed pipe 13 is connected to the inner cavity of the mixing cylinder 10. The air supply pipe 14 is laterally connected to the feed pipe 13. An air-closing valve is provided on the top of the feed pipe 13 adjacent to the air supply pipe 14. The output end of the air pump 15 is connected to the air supply pipe 15. One end of the air pipe 14 is fixedly connected, and the drug raw materials are added into the mixing cylinder 10 through the feed pipe 13. The stirring motor 12 is started, and the stirring motor 12 drives the stirring rod 11 to rotate, stirring and mixing the raw materials in the mixing cylinder 10. At the same time, the drive cylinder 18 drives the side wall scraper 17 to move up and down. The side wall scraper 17 scrapes off the raw materials adhering to the inner wall of the mixing cylinder 10, making the raw materials more uniformly mixed. When feeding, the air-closing valve is opened and the air pump 15 is started. The air pump 15 blows air into the feed pipe 13 through the air supply pipe 14. The airflow blows any raw materials that may remain in the feed pipe 13 into the mixing cylinder 10, ensuring that all the raw materials enter the mixing cylinder 10. Then the discharge valve is opened, and the mixed raw materials enter the granulation mechanism through the discharge pipe 16. This can make the drug raw materials fully and evenly mixed, improve the utilization rate of raw materials, reduce the residue of raw materials in the mixing cylinder 10, and provide stable raw materials for subsequent granulation. The pelletizing mechanism includes a fixed frame 35, a pelletizing cylinder 36, a pressure roller 37, a pelletizing disc 38 with holes, a rotating rod 39, and a geared motor 40 for driving the rotating rod 39 to rotate. The pelletizing cylinder 36 is fixedly mounted on the fixed frame 35, and the top of the pelletizing cylinder 36 is connected to the inner cavity of the feed pipe 16. The rotating rod 39 is rotatably mounted on the fixed frame 35. The geared motor 40 is fixedly mounted on the fixed frame 35, and the output end of the geared motor 40 is fixedly connected to one end of the rotating rod 39. One end of the rotating rod 39 is fixedly connected to the bottom of the pelletizing disc 38. The pressure roller 37 is rotatably installed inside the granulation cylinder 36 and is located above the granulation disc 38. The granulation cylinder 36 has a granulation outlet 41 on one side near the bottom of the granulation disc 38. The raw materials mixed by the mixing and granulation components enter the granulation cylinder 36 through the feeding pipe 16. The reduction motor 40 drives the rotating rod 39 to rotate, and the rotating rod 39 drives the granulation disc 38 to rotate. The pressure roller 37 rotates inside the granulation cylinder 36 and squeezes the raw materials on the granulation disc 38. The raw materials are squeezed into granules through the holes on the granulation disc 38 and then discharged from the granulation outlet 41.

[0030] In some embodiments, reference is made to Figures 8-10 As shown, the tablet press includes a frame 19, a pressing block 20, a fixed base 21, a forming plate 22, a top block 23, a first thrust cylinder 24, and a second thrust cylinder 25. The first thrust cylinder 24 is fixedly installed on the top of the frame 19, and its output end is fixedly connected to the top of the pressing block 20. The bottom of the pressing block 20 is provided with multiple pressing needles 26. The fixed base 21 is fixedly installed on one side of the frame 19. The forming plate 22 is fixedly installed on the top of the fixed base 21. The forming plate 22 is provided with multiple forming channels 27. The second thrust cylinder 25 is fixedly installed on the fixed base 21, and its output end is fixedly connected to the top block 23. The top of the top block 23 is provided with multiple ejector needles 28. The forming plate 22 is also provided with a pushing mechanism for pushing the dried formulation granules into the forming channels 27. The ejector pin 28, the forming groove 27 and the pressure pin 26 are in corresponding positions, and the forming groove 27 is located between the ejector pin 28 and the pressure pin 26. The feeding mechanism includes a mounting base 42, a feeding electric cylinder 43, a feeding frame 44, and two opposing guide rods 45. The mounting base 42 is fixedly mounted on the forming plate 22, the feeding electric cylinder 43 is fixedly mounted on the mounting base 42, the output end of the feeding electric cylinder 43 is fixedly connected to one side of the feeding frame 44, the two guide rods 45 are fixedly mounted on both ends of the mounting base 42, and the two sides of the feeding frame 44 are slidably mounted on the two guide rods 45. The feeding frame 44 is provided with multiple partition plates 46. A pusher plate 47 is provided on one side of the feeding frame 44, and a discharge groove 48 is provided on one side of the forming plate 22. The discharge groove 48 is positioned opposite to the pusher plate 47. The pusher cylinder 43 of the pushing mechanism pushes the feeding frame 44 to slide on the guide rod 45. The separator plate 46 in the feeding frame 44 separates the dried preparation granules. The feeding frame 44 pushes the granules into the forming groove 27 of the forming plate 22. The first pusher cylinder 24 pushes the pressing block 20 downward. The pressing needle 26 at the bottom of the pressing block 20 presses into the granules in the forming groove 27, pressing the granules into tablets. The second pusher cylinder 25 pushes the top block 23 upward. The ejector needle 28 at the top of the top block 23 ejects the tablets pressed in the forming groove 27. The tablets are discharged through the discharge groove 48.

[0031] Example 2 In a specific implementation process, refer to Figure 10 As shown, the method for manufacturing nicotinic acid tablets using the equipment includes the following steps: Step 1: Raw material mixing and granulation: Weigh nicotinic acid, lactose, hydroxypropyl methylcellulose and glycerin excipients according to the prescription ratio, and add them into the mixing cylinder 10 through the feed pipe 13. Start the stirring motor 12 to make the stirring rod 11 rotate. Add an appropriate amount of binder during the mixing process. At the same time, drive the electric cylinder 18 to drive the side wall scraper 17 to move up and down to scrape off the raw materials adhering to the inner wall of the mixing cylinder 10, ensuring that the raw materials are mixed evenly. After mixing for a period of time, open the air-closing valve and start the air pump 15 to blow air into the feed pipe 13 through the air supply pipe 14 to blow the residual raw materials into the mixing cylinder 10. Then open the discharge valve to let the mixed raw materials enter the granulation cylinder 36 through the discharge pipe 16. Start the reduction motor 40 to drive the rotating rod 39 and the granulation disc 38 to rotate. The pressure roller 37 squeezes the raw materials on the granulation disc 38 to make wet granules of uniform size. Step 2, Particle Drying: Open the cover 6 on the feed port 4 of the vacuum rotary drying assembly, add the prepared nicotinic acid wet particles into the double-cone cylinder 1 through the feed port 4, then close the cover 6, start the vacuum pump 29, and extract the air from the double-cone cylinder 1 through the air extraction pipe 30 to form a vacuum environment for vacuum drying. During the drying process, the pressure inside the cylinder is always lower than the atmospheric pressure. Turn on the electric heater and heat the double-cone cylinder 1 through the heat-conducting sleeve 31. At the same time, start the drive motor 32, drive the rotating rod 2 and the double-cone cylinder 1 to rotate through the sprocket 33 and chain 34. The right-angle trapezoidal heat transfer turning plate 9 turns the particles to make the particles heat evenly and perform drying treatment. After drying for a period of time, turn off the vacuum pump 29, electric heater and drive motor 32, open the discharge valve and discharge the dried nicotinic acid particles. Step 3, tableting: Add the dried granules to magnesium stearate lubricant, mix well, and then push them into the forming groove 27 of the forming plate 22 through the feeding frame 44 of the pushing mechanism. Start the first thrust cylinder 24 to push the pressing block 20 downward. The pressing pin 26 at the bottom of the pressing block 20 presses the granules in the forming groove 27 into nicotinic acid tablets. Start the second thrust cylinder 25 to push the top block 23 upward. The ejector pin 28 at the top of the top block 23 ejects the pressed nicotinic acid tablets in the forming groove 27. The nicotinic acid tablets are discharged through the discharge groove 48, completing the manufacturing of nicotinic acid tablets.

[0032] The circuits and controls involved in this invention are all existing technologies and will not be described in detail here.

[0033] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or basic characteristics. Therefore, the embodiments should be considered exemplary and non-limiting in all respects. The scope of the invention is defined by the appended claims rather than the foregoing description. Therefore, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention, and no reference numerals in the claims should be construed as limiting the scope of the claims.

[0034] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A manufacturing apparatus for manufacturing a pharmaceutical preparation, characterized by comprising: Including mixing granulation assembly, vacuum rotary drying assembly and tablet press, the vacuum rotary drying assembly is located between the mixing granulation assembly and the tablet press; The vacuum rotary drying assembly includes a double-cone cylinder (1), a vacuum mechanism, a heating sleeve, two opposite rotating rods (2), and two opposite fixed columns (3). The double-cone cylinder (1) is fixedly connected with the two rotating rods (2) on both sides. The double-cone cylinder (1) is provided with a feeding port (4) and a discharging port (5) at the top and bottom ends respectively. The feeding port (4) is provided with a cover (6), and the discharging port (5) is provided with a discharging valve. The two rotating rods (2) are rotatably installed on the two fixed columns (3), and the inner cavity of one of the rotating rods (2) is connected with the vacuum mechanism and the inner cavity of the double-cone cylinder (1). The heating sleeve is arranged on the outer side wall of the double-cone cylinder (1). The inner part of one of the fixed columns (3) is further provided with a driving mechanism for driving the rotating rod (2) to rotate. The end of the rotating rod (2) with a cavity is provided with a filter cover (7) between the inner side wall of the double-cone cylinder (1). The filter cover (7) is provided with a plurality of filter cores (8) arranged in a diagonal radial manner. The inner wall of the double-cone cylinder (1) is provided with a plurality of right trapezoidal heat transfer turnover plates (9) along the generatrix direction.

2. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 1, wherein The mixing granulation assembly includes a mixing cylinder (10), a stirring rod (11), a stirring motor (12), a feeding pipe (13), a gas supply pipe (14), a blowing pump (15), and a granulation mechanism. The mixing cylinder (10) is fixedly installed on the input end of the granulation mechanism. The bottom of the mixing cylinder (10) is provided with a discharge pipe (16) in communication with the input end of the granulation mechanism. The discharge pipe (16) is provided with a discharge valve. The stirring motor (12) is fixedly installed on the top of the mixing cylinder (10). The output end of the stirring motor (12) is fixedly connected with one end of the stirring rod (11). The bottom of the stirring rod (11) is located in the mixing cylinder (10). The inner side of the mixing cylinder (10) is further provided with a side wall scraper (17). The top of the mixing cylinder (10) is provided with a driving electric cylinder (18) for driving the side wall scraper (17) to move up and down. The feeding pipe (13) is in communication with the inner cavity of the mixing cylinder (10). The gas supply pipe (14) is transversely connected with the feeding pipe (13). The top of the feeding pipe (13) adjacent to the gas supply pipe (14) is provided with a gas closing valve. The output end of the blowing pump (15) is fixedly connected with one end of the gas supply pipe (14).

3. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 1, wherein The tablet press comprises a rack (19), a pressing block (20), a fixed seat (21), a forming plate (22), a top block (23), a first pushing electric cylinder (24) and a second pushing electric cylinder (25), the first pushing electric cylinder (24) is fixedly installed on the top of the rack (19), the output end of the first pushing electric cylinder (24) is fixedly connected with the top of the pressing block (20), the bottom of the pressing block (20) is provided with a plurality of pressing pins (26), the fixed seat (21) is fixedly installed on one side of the rack (19), the forming plate (22) is fixedly installed on the top of the fixed seat (21), a plurality of forming through grooves (27) are arranged on the forming plate (22), the second pushing electric cylinder (25) is fixedly installed on the fixed seat (21), the output end of the second pushing electric cylinder (25) is fixedly connected with the top block (23), the top of the top block (23) is provided with a plurality of top pins (28), and a pushing mechanism for pushing the dried preparation particles into the forming through grooves (27) is further arranged on the forming plate (22). The top pin (28), the forming through groove (27) and the pressing pin (26) correspond in position, and the forming through groove (27) is located between the top pin (28) and the pressing pin (26).

4. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 3, wherein The vacuum mechanism comprises a vacuum pump (29) and a suction pipe (30), the vacuum pump (29) is located on one side of the fixed column (3), the output end of the vacuum pump (29) is fixedly connected with one end of the suction pipe (30), the other end of the suction pipe (30) is rotatably connected with the rotating rod (2) having a cavity, and the suction pipe (30) is in communication with the inner cavity of the rotating rod (2).

5. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 4, wherein The heating set comprises a heat-conducting sleeve (31) and an electric heater, the heat-conducting sleeve (31) is fixedly installed outside the double-cone type cylinder (1), and the electric heater is fixedly installed inside the heat-conducting sleeve (31).

6. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 5, wherein The driving mechanism comprises a driving motor (32), two opposite chain wheels (33) and a chain (34), the driving motor (32) is fixedly installed on the inner side wall of the fixed column (3), the output end of the driving motor (32) is fixedly connected with a shaft rod, two chain wheels (33) are respectively fixedly installed on the shaft rod and the surface of the rotating rod (2), and the two chain wheels (33) are connected through the chain (34).

7. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 6, wherein The granulating mechanism comprises a fixing frame (35), a granulating cylinder (36), a pressing roller (37), a granulating disc (38) with holes, a rotating rod (39) and a speed reducer motor (40) for driving the rotating rod (39) to rotate, the granulating cylinder (36) is fixedly installed on the fixing frame (35), and the top of the granulating cylinder (36) is communicated with the inner cavity of the feeding pipe (16), the rotating rod (39) is rotatably installed on the fixing frame (35), the speed reducer motor (40) is fixedly installed on the fixing frame (35), and the output end of the speed reducer motor (40) is fixedly connected with one end of the rotating rod (39), one end of the rotating rod (39) is fixedly connected with the bottom of the granulating disc (38), the pressing roller (37) is rotatably installed on the inner side of the granulating cylinder (36), and the pressing roller (37) is located above the granulating disc (38), and the granulating cylinder (36) is provided with a granulating opening (41) adjacent to one side below the granulating disc (38).

8. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 7, wherein The pushing mechanism comprises a mounting seat (42), a pushing electric cylinder (43), a feeding frame (44) and two opposite guide rods (45), the mounting seat (42) is fixedly installed on the forming plate (22), the pushing electric cylinder (43) is fixedly installed on the mounting seat (42), the output end of the pushing electric cylinder (43) is fixedly connected with one side of the feeding frame (44), and two guide rods (45) are respectively fixedly installed on the two ends of the mounting seat (42), the two sides of the feeding frame (44) are respectively slidably installed on the two guide rods (45), and a plurality of partition plates (46) are arranged in the feeding frame (44).

9. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 8, wherein One side of the feeding frame (44) is further provided with a pushing plate (47), one side of the forming plate (22) is further provided with a discharging groove (48), and the discharging groove (48) is located in position corresponding to the pushing plate (47).

10. The manufacturing apparatus for manufacturing a pharmaceutical preparation according to claim 9, wherein The method for preparing the nicotinic acid tablets by using the preparation device comprises the following steps: Step one, raw material mixing and granulating: nicotinic acid, lactose, hydroxypropyl methyl cellulose and glycerol auxiliary materials are weighed according to the prescription proportion, are added into the mixing cylinder (10) through the feeding pipe (13), the stirring motor (12) is started, and the stirring rod (11) is rotated, an appropriate amount of adhesive is added in the stirring process, meanwhile, the electric cylinder (18) drives the side wall scraper (17) to move up and down, and the raw materials adhered to the inner wall of the mixing cylinder (10) are scraped off, so that the raw materials are uniformly mixed, after mixing for a period of time, the air valve is opened, the air blowing pump (15) is started, air is blown into the feeding pipe (13) through the air supply pipe (14), and the residual raw materials are blown into the mixing cylinder (10), then the discharging valve is opened, the mixed raw materials are fed into the granulating cylinder (36) through the discharging pipe (16), the speed reducer motor (40) is started, the rotating rod (39) and the granulating disc (38) are driven to rotate, the pressing roller (37) extrudes the raw materials on the granulating disc (38), and wet granules with uniform size are prepared; Step two, particle drying: open the cover (6) on the feed inlet (4) of the vacuum rotary drying assembly, add the prepared wet nicotine particles into the double-cone cylinder (1) through the feed inlet (4), then close the cover (6), start the vacuum pump (29), and exhaust the air in the double-cone cylinder (1) through the exhaust pipe (30) to form a vacuum environment for vacuum drying. During the drying process, the pressure in the cylinder is always lower than the atmospheric pressure. Turn on the electric heater to heat the double-cone cylinder (1) through the heat shield (31), and start the drive motor (32) to rotate the rotating rod (2) and the double-cone cylinder (1) through the chain wheel (33) and the chain (34). The right-angle trapezoidal heat transfer turning plate (9) turns the particles to make them evenly heated for drying. After a period of drying, turn off the vacuum pump (29), the electric heater and the drive motor (32), and open the discharge valve to discharge the dried nicotine particles. Step three, tabletting: add magnesium stearate lubricant to the dried particles, mix well, and then push into the forming channel (27) of the forming plate (22) through the upper feeding frame (44) of the pushing mechanism. Start the push cylinder (24) to push the pressing block (20) downward, and the pressing needle (26) at the bottom of the pressing block (20) presses the particles in the forming channel (27) into nicotine tablets. Start the push cylinder (25) to push the top block (23) upward, and the ejector pin (28) at the top of the top block (23) ejects the nicotine tablets in the forming channel (27). The nicotine tablets are discharged through the discharge chute (48), and the manufacturing of the nicotine tablets is completed.

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