Full-automatic biochemical analyzer

Abstract

The invention discloses a full-automatic biochemical analyzer which comprises a reaction device, a detection device and a sampling transfer device arranged above the reaction device, the reaction device comprises a detection bottom plate, a rotary driving mechanism and a light source assembly; the rotary driving mechanism is mounted on the detection bottom plate, and the rotary driving mechanism is also in driving connection with a tray for bearing a reagent disc; an incubation assembly is further mounted at the position, corresponding to the rotary driving mechanism, of the top of the detection bottom plate, and the tray and the reagent disc borne by the tray are located in the incubation assembly. The circular-arc-shaped reagent disc is utilized, the reaction hole sites are more, indexes of a plurality of samples can be detected at the same time, the detection items are more, and the detection efficiency is high.

Description

Technical Field

[0001] This invention relates to the field of biomedical device technology, and in particular to a fully automated biochemical analyzer. Background Technology

[0002] Biochemical analysis is one of the most commonly used and important methods in clinical diagnosis. By analyzing blood or other body fluids to measure various biochemical indicators, and combining this with other clinical data for comprehensive analysis, it helps to diagnose the type of disease, evaluate organ function, identify comorbidities, and determine the basis for subsequent treatment.

[0003] Currently, there are two main types of biochemical analyzers on the market. One type is microfluidic technology, whose main drawback is that the reaction system is too small, which causes detection errors. In addition, microfluidic technology requires very high rotation speed, which places high demands on the rotary motor, resulting in higher costs. Moreover, microfluidics requires high precision, which also increases manufacturing costs. The other type is reagent strips, whose main drawback is that the number of reagent wells is small, and the number of detection items is limited. Summary of the Invention

[0004] The purpose of this invention is to provide a fully automated biochemical analyzer that utilizes an arc-shaped reagent tray with multiple reaction wells, enabling simultaneous detection of indicators from multiple samples, and offering a wide range of detection items and high detection efficiency.

[0005] To achieve the above objectives, the following technical solution is adopted: A fully automated biochemical analyzer includes a reaction device, a detection device, and a sampling transfer device arranged above the reaction device. The reaction device includes a detection base plate, a rotary drive mechanism, and a light source assembly. The rotary drive mechanism is mounted on the detection base plate and also drives a tray connected to it for carrying a reagent tray. An incubation assembly is also installed on the top of the detection base plate corresponding to the rotary drive mechanism, and the tray and the reagent tray it carries are located within the incubation assembly. The light source assembly is mounted on the detection base plate and located within the incubation assembly, and a light outlet is provided on the incubation assembly corresponding to the light-emitting end of the light source assembly. The detection device includes a detection component and an optical fiber assembly. The detection component is mounted on the detection base plate, and the optical fiber assembly connects the detection component and the light outlet.

[0006] Furthermore, the incubation assembly includes a support column connected to one end of the top of the detection base plate, a heating base plate mounted on the support column, and a retaining ring mounted on the heating base plate; both the heating base plate and the retaining ring are annular in structure, and a heating film is also provided at the bottom of the heating base plate; the light outlet is opened on the side wall of the retaining ring; the light source assembly includes a light source base and a light-emitting element; the light source base is mounted on the detection base plate and located inside the retaining ring; a first mounting cavity is opened at one end of the light source base, and the light-emitting element is installed in the first mounting cavity; an optical passage penetrating to the first mounting cavity is also opened on one side of the light source base corresponding to the light outlet. The optical channel includes a first lens; a lens cover plate is installed on one side of the light source base to press and limit the first lens within the optical channel; the light-emitting element includes a lamp holder and a halogen tungsten lamp fixed on the lamp holder; a first sealing ring is also embedded in the optical channel, and a limiting boss is provided on one side of the lens cover plate, which is inserted into the optical channel and used to press and limit the first sealing ring and the first lens; the rotary drive mechanism includes a first motor installed on the bottom of the detection base plate, and the output shaft of the first motor is also driven to connect a connecting bushing; the connecting bushing is located inside the retaining ring, and the tray is connected to the connecting bushing.

[0007] Furthermore, the optical fiber assembly includes a main optical fiber head, a first optical fiber pressure plate, and several detection optical fibers; one end of each detection optical fiber is converged into a single strand and integrated within the main optical fiber head, and the other end of each detection optical fiber is also provided with a secondary optical fiber head; the main optical fiber head is installed inside the light outlet, and the secondary optical fiber head is connected to the detection assembly; the first optical fiber pressure plate is installed on the side wall of the retaining ring, and the first optical fiber pressure plate is used to limit and fix the main optical fiber head; the main optical fiber head has an internal axially hollow structure; the main optical fiber head includes a first cylindrical part, a second cylindrical part, and a third cylindrical part that are coaxially arranged and integrally connected in sequence; the first cylindrical part is inserted into the light outlet; the first optical fiber pressure plate also has a first stepped hole and a second stepped hole communicating with the first stepped hole; the second cylindrical part is engaged in the first stepped hole, and the third cylindrical part is engaged in the second stepped hole; a first slit penetrating into the first and second stepped holes is also opened on one side of the first optical fiber pressure plate.

[0008] Furthermore, the detection assembly includes a detection bracket connected to the other end of the top of the detection base plate, an optical mounting base mounted on the detection bracket, a second fiber pressure plate connected to one side of the optical mounting base, and a detection PCB board connected to the other side of the optical mounting base. The optical mounting base has a plurality of first mounting holes spaced apart along its length on one side, and a plurality of second mounting holes also have a plurality of second mounting holes on the other side, with each second mounting hole corresponding to and communicating with a first mounting hole. The secondary fiber head of each detection fiber is inserted into a corresponding first mounting hole, and a filter is also installed in each second mounting hole. The detection PCB board is further provided with several photodiodes on one side, each photodiode being inserted into a second mounting hole; the secondary fiber head has an internal axial hollow structure; the secondary fiber head includes a fourth cylindrical part and a fifth cylindrical part that are coaxially arranged and integrally connected; the fourth cylindrical part is inserted into a first mounting hole; the bottom of the second fiber pressure plate has a sawtooth structure, and the arc between each two adjacent sawtooths is correspondingly locked onto the fifth cylindrical part of the secondary fiber head; a second sealing ring is also embedded in the second mounting hole, and the second sealing ring is located between the photodiode and the filter.

[0009] Furthermore, it also includes a frame base plate and a fixed bracket connected to the frame base plate; a first translation mechanism is arranged on the top of the frame base plate along its length, and the first translation mechanism is also driven to connect to a first translation seat; the detection base plate is connected to the top of the first translation seat; the sampling transfer device includes a Z-axis lifting mechanism installed on the upper part of one side of the fixed bracket, and a pipette connected to the Z-axis lifting mechanism; the pipette is arranged above the tray; a barcode scanner is also installed in the middle of the fixed bracket.

[0010] Furthermore, the pipette includes a pipetting base plate, a lifting drive mechanism, a cylinder, a piston rod, a plug, and a first sliding seat; the first sliding seat is slidably connected to the pipetting base plate, and the output end of the lifting drive mechanism is connected to the first sliding seat; the cylinder is mounted on the pipetting base plate, one end of the piston rod is movably inserted into the inner cavity of the cylinder, and the other end of the piston rod is connected to the first sliding seat; the plug is mounted on the bottom of the cylinder, and the bottom of the plug also has an inner hole communicating with the inner cavity of the cylinder; the lower outer wall of the plug also has an outwardly protruding limiting step; a pipetting mounting plate connected to the Z-axis lifting mechanism is also mounted on the pipetting base plate.

[0011] Furthermore, the pipette also includes a push block; the push block includes an annular portion and a fixing portion; the annular portion has an internally hollow structure and is coaxially and movably sleeved on the plug; one end of the fixing portion is connected to the outer wall of the annular portion, and the other end of the fixing portion is also connected to a guide post; a C-shaped notch is also provided on one side of the cylinder, and one end of the guide post passes through the C-shaped notch and moves out from the top of the cylinder to be arranged below the slider; a limit block is also installed on the guide post near the lower end of the C-shaped notch, and a spring is also sleeved on the guide post between the top of the limit block and the upper end of the C-shaped notch; the push block also includes a baffle connected to the outer wall of the annular portion; a limit switch is also installed on the lower part of the pipette base plate, and the notch of the baffle corresponds to the notch of the limit switch.

[0012] Furthermore, the reagent tray includes a semi-circular tray body, and the tray body is provided with a sample hole, a sampling needle support, a quality control liquid hole, a diluent hole, and multiple detection holes; a concave first notch is provided on the non-arc side of the tray body, and a first buckle is connected to one side wall of the first notch; a second buckle is also connected to the arc side wall of the tray body; and a positioning post is provided at the bottom of the tray body.

[0013] Furthermore, an outer shell is connected to the base plate of the frame, and a fixed bracket is located inside the outer shell; an inlet and outlet are provided at the lower part of one end of the outer shell, and a door assembly is installed at the inlet and outlet; a control panel is rotatably connected to the top end of the outer shell; and the reaction device is arranged near the inlet and outlet.

[0014] Furthermore, the door assembly includes a fixed plate, a door panel, and a door bracket; the fixed plate is mounted on the frame base plate, and the fixed plate has a first groove and a second groove, with the second groove arranged on one side of the first groove; a rotating shaft bracket is installed at each end of the first groove, and one end of each rotating shaft bracket extends into the second groove; one end of the rotating shaft bracket is also rotatably connected to a rotating shaft; the door panel is arranged inside the inlet / outlet, the door bracket is installed on one side of the door panel, and two connecting claws are also connected to the door bracket; one end of each of the two connecting claws is respectively connected to a rotating shaft; a torsion spring is also sleeved on the rotating shaft, and the two ends of the torsion spring are respectively connected to the rotating shaft bracket and the connecting claw; a first top block is installed at the end of the detection base plate facing the door panel, and a second top block is also installed at the end of the first translation seat facing the door panel.

[0015] By adopting the above solution, the beneficial effects of the present invention are: 1) The circular arc-shaped reagent tray has a large number of wells, high throughput, and can detect a variety of items. It is easy to pick up and put down, stable in place, and has a low manufacturing cost. At the same time, it can facilitate the addition of reagents, effectively realize the detection of various parameters of the sample, and improve the detection efficiency. 2) By using optical fiber for beam splitting, the distance from the output port to each detection photodiode is consistent, resulting in uniform light transmission distance, less light flux loss, and more stable detection results. In addition, the optical path installation structure is simple and the assembly efficiency is high. Furthermore, the cost is lower than that of using dichroic mirrors for beam splitting, and the detection efficiency is also relatively higher. 3) It can perform actions such as liquid aspiration and transfer of reagents, as well as picking up and unloading of sampling needles, and automatically puncturing the heat-sealed aluminum film of the reagent tray. The pipette of this invention integrates multiple functions into one mechanism, which greatly saves equipment space, reduces costs, and improves production efficiency. At the same time, the cylinder and motor screw drive of the pipette are symmetrically arranged, which greatly reduces the height of the instrument and makes the equipment smaller. 4) It can automatically open or close, and when closed, the device can be sealed to prevent light leakage from affecting the test results. Attached Figure Description Figure 1 This is a schematic diagram of the structure of the present invention; Figure 2 This is a schematic diagram of the structure of the present invention after the door is opened; Figure 3 This is a schematic diagram of the structure of the present invention without the outer shell; Figure 4 for Figure 3 A structural diagram from another perspective; Figure 5 This is a schematic diagram of the reaction apparatus and detection apparatus of the present invention; Figure 6 This is a cross-sectional view of the reaction apparatus and detection apparatus of the present invention; Figure 7 This is a schematic diagram of the structure of the light source assembly of the present invention; Figure 8 This is an exploded view of the light source assembly of the present invention; Figure 9 This is a schematic diagram of the optical fiber assembly of the present invention; Figure 10 This is a schematic diagram of the structure of the first optical fiber pressure plate of the present invention; Figure 11 This is a schematic diagram of the reagent tray of the present invention; Figure 12 This is a schematic diagram of the pipette structure of the present invention; Figure 13 for Figure 12 A structural diagram from another perspective; Figure 14 This is a cross-sectional view of the pipette of the present invention; Figure 15 This is a partial structural diagram of the compartment door of the present invention when it is opened; Figure 16 This is a partial cross-sectional view of the compartment door of the present invention when it is open; The following are explanations of the labels in the attached diagram: 1. Reaction apparatus; 2. Detection apparatus; 3. Sampling and transfer apparatus; 4. Frame base plate; 5. Fixed bracket; 11. Detection base plate; 12. Rotary drive mechanism; 13. Light source assembly; 14. Detection assembly; 15. Fiber optic assembly; 16. Incubation assembly; 17. Tray; 18. Reagent tray; 31. Z-axis lifting mechanism; 32. Pipette; 41. First translation mechanism; 42. First translation seat; 43. Housing; 44. Door assembly; 45. Control panel; 51. Barcode scanner; 121. First motor; 122. Connecting bushing; 131. Light source base; 132. Optical channel; 133. First lens; 134. Lens cover plate; 135. Lamp holder; 136. Halogen 137. Tungsten lamp; 141. First sealing ring; 142. Detection bracket; 143. Optical mounting base; 144. Second fiber optic pressure plate; 145. Detection PCB board; 146. Filter; 147. Photodiode; 148. Second sealing ring; 151. Main fiber optic head; 152. First fiber optic pressure plate; 153. Detection fiber; 154. Secondary fiber optic head; 161. Heating base plate; 162. Retaining ring; 163. Light outlet; 181. Disk body; 182. Sample hole; 183. Sampling needle bracket; 184. Quality control liquid hole; 185. Diluent hole; 186. Detection hole; 321. Pipette base plate; 322. Lifting drive mechanism; 323. Cylinder; 324. Piston rod; 325. Plug; 326. First sliding seat; 327. Push block; 328. Pipetting mounting plate; 441. Fixing plate; 442. Door panel; 443. Door bracket; 444. Rotary shaft bracket; 445. Rotating shaft; 446. Connecting claw; 447. Torsion spring; 1511. First cylindrical part; 1512. Second cylindrical part; 1513. Third cylindrical part; 1521. First stepped hole; 1522. Second stepped hole; 1523. First gap; 1541. Fourth cylindrical part; 1542. Fifth cylindrical part; 1811. First notch; 1812. First latch; 1813. Second latch; 1814. Positioning post; 1851. Guide step; 185 2. Bottom hole; 3221. Motor bracket; 3222. Drive motor; 3223. Screw and nut assembly; 3224. First guide rail; 3225. Guide slide hole; 3231. C-shaped notch; 3232. Third sealing ring; 3233. Fourth sealing ring; 3251. Limiting step; 3271. Circular part; 3272. Fixing part; 3273. Guide post; 3274. Limiting block; 3275. Spring; 3276. Baffle; 3277. Limit switch; 4411. First groove; 4412. Second groove; 4421. EVA foam; 44101. Front plate; 44102. Panel; 44103. First top block; 44104. Second top block. Detailed Implementation

[0016] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments.

[0017] Reference Figures 1 to 16 As shown, the present invention provides a fully automated biochemical analyzer. In one embodiment, it includes a reaction device 1, a detection device 2, and a sampling transfer device 3 arranged above the reaction device 1. The reaction device 1 includes a detection base plate 11, a rotary drive mechanism 12, and a light source assembly 13. The rotary drive mechanism 12 is mounted on the detection base plate 11 and also drives a tray 17 for carrying a reagent tray 18. An incubation assembly 16 is also installed on the top of the detection base plate 11 at a position corresponding to the rotary drive mechanism 12. The tray 17 and the reagent tray 18 carried by the tray 17 are located within the incubation assembly 16. The light source assembly 13 is mounted on the detection base plate 11 and located within the incubation assembly 16. A light outlet 163 is also provided on the incubation assembly 16 at a position corresponding to the light-emitting end of the light source assembly 13. The detection device 2 includes a detection component 14 and an optical fiber assembly 15. The detection component 14 is mounted on the detection base plate 11, and the optical fiber assembly 15 is connected between the detection component 14 and the light outlet 163.

[0018] In this embodiment, the incubation assembly 16 includes a support column connected to one end of the top of the detection base plate 11, a heating base plate 161 mounted on the support column, and a retaining ring 162 mounted on the heating base plate 161; both the heating base plate 161 and the retaining ring 162 are annular in structure, and a heating film is also provided at the bottom of the heating base plate 161; the light outlet 163 is opened on the side wall of the retaining ring 162.

[0019] Both the heating base plate 161 and the retaining ring 162 are circular with a hollow center. A heating film is provided at the bottom of the heating base plate 161 to heat the heating base plate 161. The rotary drive mechanism 12 is located at the hollow center of the heating base plate 161 and is fixed on the base. The light source assembly 13 is located at the hollow center of the heating base plate 161 and is fixed on the base. The light source assembly 13 is on one side of the rotary drive mechanism 12.

[0020] Preferably, the rotary drive mechanism 12 includes a first motor 121 installed at the bottom of the detection base plate 11, and the output shaft of the first motor 121 is also connected to a connecting bushing 122; the connecting bushing 122 is located inside the retaining ring 162, and the tray 17 is connected to the connecting bushing 122. The first motor 121 is fixedly connected to the tray 17 through the motor connecting bushing 122. When the first motor 121 rotates, it can drive the tray 17 to make a circular motion. The reagent tray 18 of the biochemical analyzer is installed and fixed inside the tray 17, so that it can drive the reagent tray 18 to make a circular motion. Thus, during detection, light can pass through the detection holes 186 on the reagent tray 18 in sequence, so that the reagent sample mixture in different detection holes 186 can be detected in sequence, so that different indicators can be detected in different detection holes 186, thereby effectively improving the detection efficiency.

[0021] Specifically, when the first motor 121 drives the connecting sleeve 122 to rotate, it simultaneously drives the tray 17 and reagent tray 18 to rotate together. At this time, the light source assembly 13 and the incubation assembly 16 are fixed on the detection base plate 11. The light source base 131 and the motor connecting sleeve 122 are spaced apart to prevent interference between their relative movements. The retaining ring 162 is circular and fixed on the heating base plate 161. The retaining ring 162, the motor connecting sleeve 122, and the reagent tray 17 are concentric. The inner ring of the retaining ring 162 matches the outer ring of the tray 17, and there is a certain gap between them. When the tray 17 rotates, it is necessary to ensure that the tray 17 does not interfere with the retaining ring 162. The heating base plate 161 and the retaining ring 162 form a semi-enclosed shape around the tray 17, which allows the tray 17 to heat up quickly and ensures the stability of the detection data. Preferably, the heating base plate 161 and the retaining ring 162 are both made of metal materials with good thermal conductivity to facilitate rapid heating. At the same time, the outer ring of the retaining ring 162 is also provided with a heat-insulating coating to prevent heat loss. The side wall of the retaining ring 162 is also provided with a light-emitting port 163. The light-emitting port 163 is circular and is concentric with the optical channel 132 on the light source base 131 to facilitate the passage of light. During detection, the detection hole 186 of the reagent tray 18 should be directly opposite the optical channel 132.

[0022] In a preferred embodiment, the light source assembly 13 includes a light source base 131 and a light-emitting element; the light source base 131 is mounted on the detection base plate 11 and located within the retaining ring 162; a first mounting cavity is provided at one end of the light source base 131, and the light-emitting element is installed in the first mounting cavity; an optical channel 132 is also provided on one side of the light source base 131 corresponding to the light outlet 163, extending into the first mounting cavity, and a first lens 133 is also installed in the optical channel 132; a lens cover plate 134 for pressing and limiting the first lens 133 within the optical channel 132 is also installed on one side of the light source base 131; the light-emitting element includes a lamp holder 135 and a halogen tungsten lamp 136 fixed on the lamp holder 135; a first sealing ring 137 is also embedded in the optical channel 132, and a limiting boss is provided on one side of the lens cover plate 134, which is inserted into the optical channel 132 and used to press and limit the first sealing ring 137 and the first lens 133.

[0023] In this embodiment, a first mounting cavity is provided at one end of the light source base 131 for mounting a halogen tungsten lamp 136. This cavity is cylindrical and its outer shape is larger than that of the halogen tungsten lamp 136. The halogen tungsten lamp 136 and the lamp holder 135 are designed as an integral part. Preferably, the halogen tungsten lamp 136 is fixed to the lamp holder 135 by alumina ceramic powder, which has excellent thermal conductivity. The lamp holder 135 is fixed to the light source base 131, and the body of the halogen tungsten lamp 136 is concentric with the cavity. At the same time, the light source base 131 is also provided with an optical channel 132. The lens 134 is equipped with a first lens 133 (plano-convex lens) and a first sealing ring 137 (rubber ring). The center of the plano-convex lens is aligned with the light-emitting center of the halogen lamp 136, so that the light emitted by the halogen lamp 136 becomes parallel light after passing through the plano-convex lens, which allows the light to travel further and the light received by the photodiode 146 to be more stable and have stronger energy. A limiting boss is also provided on one side of the lens cover plate 134. This boss is positioned and installed with the optical channel 132. While pressing the first sealing ring 137, the boss can also press the first lens 133 into the optical channel 132.

[0024] In a preferred embodiment, the optical fiber assembly 15 includes a main optical fiber head 151, a first optical fiber clamping plate 152, and a plurality of detection optical fibers 153; one end of each of the plurality of detection optical fibers 153 is converged into a single strand and integrated within the main optical fiber head 151, and the other end of each detection optical fiber 153 is also provided with a secondary optical fiber head 154; the main optical fiber head 151 is installed within the light outlet 163, and the secondary optical fiber head 154 is connected to the detection assembly 14; the first optical fiber clamping plate 152 is installed on the side wall of the retaining ring 162, and the first optical fiber clamping plate 152 is used to limit and fix the main optical fiber head 151; the main optical fiber head 151 has an internal axially hollow structure; the main optical fiber head 151 51 includes a first cylindrical portion 1511, a second cylindrical portion 1512, and a third cylindrical portion 1513, which are coaxially arranged and integrally connected in sequence; the first cylindrical portion 1511 is inserted into the light outlet 163; the first fiber pressure plate 152 is also provided with a first stepped hole 1521 and a second stepped hole 1522 communicating with the first stepped hole 1521; the second cylindrical portion 1512 is engaged in the first stepped hole 1521, and the third cylindrical portion 1513 is engaged in the second stepped hole 1522; a first gap 1523 is also provided on one side of the first fiber pressure plate 152, which extends into the first stepped hole 1521 and the second stepped hole 1522.

[0025] In this embodiment, several detection optical fibers 153 are provided, which can transmit light of different wavelengths, such as 340nn, 405nn, 450nn, 505nn, 546nn, 600nn, 630nn, 850nn, etc. In addition, the wavelength of 340nn belongs to ultraviolet light and the optical fiber material is ultraviolet quartz glass, while the light with wavelengths above 340nn belongs to infrared light and the material is infrared quartz glass. One end of the several detection optical fibers 153 is combined into a single strand and integrated into the main optical fiber head 151.

[0026] Preferably, the main fiber optic head 151 is composed of three cylinders with different outer diameters, and its interior is hollow. Multiple detection fibers 153 are sealed with glue inside the hollow hole of the main fiber optic head 151. The first fiber pressure plate 152 is fixed on the retaining ring 162. The first fiber pressure plate 152 also has a stepped hole in the middle, and the stepped hole is concentric with the optical channel 132 on the light source base 131. The first cylindrical part 1511 on the main fiber optic head 151 cooperates with the light outlet 163 on the retaining ring 162, so that the light emitted by the light source can be directly received by the detection fibers 153 integrated in the main fiber optic head 151. The second cylindrical part of the main fiber optic head 151... The first cylindrical portion 1512 is adapted to the first stepped hole 1521 of the first fiber pressure plate 152, and the third cylindrical portion 1513 is adapted to the second stepped hole 1522 of the first fiber pressure plate 152. Thus, the stepped surface of the first fiber pressure plate 152 limits the end face of the second cylindrical portion 1512 of the main fiber head 151, thereby fixing the main fiber head 151 on the retaining ring 162 by the first fiber pressure plate 152, thereby limiting the main fiber head 151 within the light outlet 163 of the retaining ring 162, thus ensuring the stability of the optical path. Preferably, the side of the first fiber pressure plate 152 is also provided with a gap, which allows the optical fiber to pass through for easy installation.

[0027] In one embodiment, the detection assembly 14 includes a detection bracket 141 connected to the other end of the top of the detection base plate 11, an optical mounting base 142 mounted on the detection bracket 141, a second fiber pressure plate 143 connected to one side of the optical mounting base 142, and a detection PCB board 144 connected to the other side of the optical mounting base 142; a plurality of first mounting holes are spaced apart along the length of one side of the optical mounting base 142, and a plurality of second mounting holes are also provided on the other side of the optical mounting base 142, and each second mounting hole communicates with a corresponding first mounting hole; the secondary fiber head 154 of each detection fiber 153 is inserted into a corresponding first mounting hole. Inside, a filter 145 is installed in each of the second mounting holes; a plurality of photodiodes 146 are also provided on one side of the detection PCB board 144, and each photodiode 146 is inserted into a corresponding second mounting hole; the secondary fiber head 154 has an internal axial hollow structure; the secondary fiber head 154 includes a fourth cylindrical part 1541 and a fifth cylindrical part 1542 that are coaxially arranged and integrally connected; the fourth cylindrical part 1541 is inserted into the first mounting hole; the bottom of the second fiber pressure plate 143 has a sawtooth structure, and the arc between each two adjacent sawtooths is correspondingly locked onto the fifth cylindrical part 1542 of the secondary fiber head 154.

[0028] In this embodiment, each detection fiber 153 is further provided with a secondary fiber optic head 154 at its other end. The secondary fiber optic head 154 consists of two cylinders with different outer diameters, forming a stepped surface between the two cylinders. The optical mounting base 142 is provided with a first mounting hole (for mounting the secondary fiber optic head 154) and a second mounting hole (for mounting the filter 145). The two mounting holes are stepped and concentric, ensuring that light passes through the center of the filter 145. The fourth cylindrical portion 1541 of the secondary fiber optic head 154 is adapted to the first mounting hole. The bottom of the second fiber optic pressure plate 143 has a serrated structure. The arc between them is adapted to the fifth cylindrical part 1542 of the secondary fiber head 154. After the secondary fiber head 154 is inserted into the first mounting hole in sequence, the stepped surface of the secondary fiber head 154 is flush with the right side of the optical mounting base 142. At this time, the sawtooth notch of the second fiber pressure plate 143 is inserted along the fifth cylindrical part 1542 of the secondary fiber head 154. Then the second fiber pressure plate 143 is locked on the right side of the optical mounting base 142. The stepped surface of the secondary fiber head 154 is limited by the second fiber pressure plate 143, so that the secondary fiber head 154 is firmly fixed on the optical mounting base 142 and the two will not shift, thereby ensuring the stability of the optical path.

[0029] Furthermore, the filter 145 is adapted to the second mounting hole, and a detection photodiode 146 is provided on the detection PCB board 144. The center of the photodiode 146 is aligned with the center of the second mounting hole, and the photodiode 146 is disposed within the second mounting hole. The detection PCB board 144 is locked to the left side of the optical mounting base 142. A second sealing ring 147 (rubber ring) is provided between the filter 145 and the photodiode 146. Because the rubber ring has a certain elasticity, when the detection PCB board 144 is locked on the detection mounting base, the photodiode 146 squeezes the rubber ring, and the rubber ring presses the filter 145. This design allows the filter 145 to be confined within the second mounting hole without damaging the filter 145 and the photodiode 146, thus ensuring the stability of the optical path. The filter 145 allows only one wavelength of light to pass through, while other wavelengths are absorbed. The light passing through the filter 145 is then absorbed by the photodiode 146 for detection and analysis. In this design, the filter 145 sequentially allows only light of 340nm, 405nm, 450nm, 505nm, 546nm, 600nm, 630nm, and 850nm to pass through, allowing each photodiode 146 to detect different parameters.

[0030] In a preferred embodiment, the device further includes a frame base plate 4 and a fixed bracket 5 connected to the frame base plate 4; a first translation mechanism 41 is arranged on the top of the frame base plate 4 along its length, and the first translation mechanism 41 is also driven to connect a first translation seat 42; the detection base plate 11 is connected to the top of the first translation seat 42; the sampling transfer device 3 includes a Z-axis lifting mechanism 31 installed on the upper part of one side of the fixed bracket 5, and a pipette 32 connected to the Z-axis lifting mechanism 31; the pipette 32 is arranged above the tray 17; a barcode scanner 51 is also installed in the middle of the fixed bracket 5.

[0031] The frame base plate 4 serves as a support, bearing the load of the entire device and also as a positioning platform for positioning each module. The frame base plate 4 is supported on the tabletop by foot pads. The reaction device 1 is slidably connected to the frame base plate 4 in the horizontal direction. The sampling transfer module is located above the reaction device 1 and is slidably connected to the fixed bracket 5 in the vertical direction. The reaction device 1 holds a reagent tray 18, which can rotate freely. The sampling transfer device 3 also includes a pipette 32, which is slidably connected to the fixed bracket 5 in the vertical direction and located above the reagent tray 18. The pipette 32 can draw or inject liquid from the reagent tray 18. In this embodiment, both the first translation mechanism 41 and the Z-axis lifting mechanism 31 adopt a motor lead screw transmission method.

[0032] In addition, a housing 43 is connected to the base plate 4 of the frame, and a fixed bracket 5 is located inside the housing 43; an inlet and outlet port is provided at the lower part of one end of the housing 43, and a door assembly 44 is installed at the inlet and outlet port; a control panel 45 is rotatably connected to the top end of the housing 43; the reaction device 1 is arranged near the inlet and outlet port; the door assembly 44 includes a fixed plate 441, a door plate 442, and a door bracket 443; the fixed plate 441 is installed on the base plate 4 of the frame, and a first groove 4411 and a second groove 4412 are provided on the fixed plate 441, and the second groove 4412 is arranged on one side of the first groove 4411; a rotating shaft bracket 444 is installed at each end of the first groove 4411, and each rotating shaft bracket 444... One end of 44 extends into the second groove 4412; one end of the rotating shaft bracket 444 is also rotatably connected to a rotating shaft 445; the hopper door plate 442 is arranged inside the inlet / outlet, the hopper door bracket 443 is installed on one side of the hopper door plate 442, and two connecting claws 446 are also connected to the hopper door bracket 443; one end of each of the two connecting claws 446 is respectively connected to a rotating shaft 445; a torsion spring 447 is also sleeved on the rotating shaft 445, and the two ends of the torsion spring 447 are respectively connected to the rotating shaft bracket 444 and the connecting claws 446; a first top block 44103 is installed on the end of the detection base plate 11 facing the hopper door plate 442, and a second top block 44104 is also installed on the end of the first translation seat 42 facing the hopper door plate 442.

[0033] The door panel 442 is connected to the outer casing 43 via a torsion spring 447. When the equipment is running, the door panel 442 automatically closes under the torque of the torsion spring 447. Simultaneously, a first top block 44103 and a second top block 44104 are respectively provided at one end of the detection base plate 11 and the first translation seat 42. When the equipment has finished running, the reaction device 1 slides outward horizontally under the drive of the motor, and the top blocks can push the door panel 442 open until it is fully open. At this point, the reagent tray 18 can be removed from the reaction device 1. Then, the reaction device 1... Driven by a lead screw motor, the door slides inward horizontally until the door panel 442 is fully closed under the torque of the torsion spring 447, enabling automatic opening and closing of the door without manual operation. The control panel 45 is connected to the outer casing 43 via a damping shaft, allowing the panel assembly to rotate at any suitable angle, thus improving the user's various angle usage needs. When packaging and transportation are required, the panel assembly can be rotated to a 0° angle with the top of the outer casing 43 for convenient transportation. The panel assembly can control the equipment's operating requirements and display the equipment's operating status.

[0034] Specifically, the outer shell 43 includes a front panel 44101 and a panel 44102. The key technology of this door structure is to install the door panel 442 by using a fixing plate 441 as a bridge. The fixing plate 441 is fixedly connected to the frame base plate 4. The fixing plate 441 is provided with a first groove 4411 and a second groove 4412. The rotating shaft bracket 444 is fixed in the first groove 4411. The second groove 4412 is deeper than the first groove 4411. The other end of the rotating shaft bracket 444 is provided with a rotating shaft 445. The rotating shaft 445 can rotate freely around the rotating shaft bracket 444. The entire rotating shaft 445 is set in the second groove 4412.

[0035] The door panel 442 is fixed on the door bracket 443, which can rotate freely around the rotation axis 445. The door bracket 443 is provided with two connecting claws 446. Preferably, the door bracket 443 includes a bracket plate connected to one side of the door panel 442. The two connecting claws 446 are respectively connected to the two ends of one side of the bracket plate. The connecting claws 446 have a C-shaped structure, and the arc-shaped protrusion of the connecting claws 446 is arranged upward. One C-shaped end of the connecting claws 446 is connected to the bracket plate, and the other C-shaped end of the connecting claws 446 is connected to the rotation axis 445.

[0036] The entire rotating mechanism is much lower than the upper plane of the frame base plate 4. During the rotation of the C-shaped claw, the notch of the C-shaped claw just avoids the front plate 44101 and the frame base plate 4. A spring 3275 is also installed on the rotating shaft 445. The spring 3275 can rotate freely around the rotating shaft 445. One end of the spring 3275 is fixed to the rotating shaft bracket 444, and the other end of the spring 3275 is fixed to the C-shaped claw. The spring 3275 is a torsion spring 447, made of spring 3275 steel. When the torsion spring 447 is compressed, it will generate a large elastic force. Therefore, when the spring 3275 is installed on the C-shaped claw and the rotating shaft bracket 444, the spring 3275 is in a compressed state. Therefore, under the natural state, the door plate 442 is closed under the drive of the spring 3275.

[0037] The front panel 44101 is fixed to the frame of the biochemical analyzer. The front panel 44101 has a square opening, the area of ​​which is smaller than the area of ​​the door panel 442. Therefore, when the door panel 442 is fully closed, it can completely cover the square opening. Preferably, the rotating shaft bracket 444 includes a rotating shaft horizontal plate installed in the first groove 4411, and a rotating shaft vertical plate is integrally connected to the top end of the rotating shaft horizontal plate. One end of the rotating shaft vertical plate extends into the second groove 4412, and the rotating shaft 445 is rotatably connected to the rotating shaft vertical plate. An EVA foam 4421 is also connected to one side of the door panel 442, and an avoidance notch is provided on the EVA foam 4421. The bracket plate is located in the avoidance notch.

[0038] EVA foam 4421 is attached to the door panel 442. When the door panel 442 is closed, because EVA foam 4421 is very soft, it deforms under the force of spring 3275 to press the front panel 44101, thereby forming a sealed structure between the front panel 44101 and the door, so that outside light will not leak into the interior of the biochemical analyzer.

[0039] The device is also equipped with a first top block 44103 and a second top block 44104. When the reaction device 1 needs to exit the chamber, the first top block 44103 first pushes the chamber door 442 to open partially. After the chamber door 442 is opened to a certain angle, the second top block 44104 starts to push the chamber door 442 to continue opening until the reaction device 1 is completely exiting the chamber. At this time, the chamber door 442 is also fully open. Under the driving force of the screw motor, the reaction device 1 and the chamber door 442 remain stationary. When the reaction device 1 enters the chamber, as the reaction device 1 enters, the chamber door 442 is also slowly closed under the force of the spring 3275 until the reaction device 1 is completely inside the equipment. The chamber door is also fully closed, thus realizing automatic opening and closing of the chamber door without manual operation.

[0040] In addition, preferably, a panel 44102 is also fixed to the outside of the front panel 44101. The panel 44102, as an appearance component, has a smooth surface and good texture, and is generally made of black glossy acrylic material. The panel 44102 and the front panel 44101 form a step. When the door panel 442 is closed, it will be locked in the step. At this time, the outer surface of the door panel 442 is flush with the outer surface of the panel 44102. The side of the door panel 442 and the side of the hole of the panel 44102 form a decorative seam with a gap of 0.5~1mm, so the appearance is more beautiful.

[0041] In addition, a sealed structure is formed between the fixed plate 441 and the frame base plate 4 to prevent light leakage. The rotating mechanism always rotates within the second groove 4412, and the first groove 4411 and the second groove 4412 are also in a closed state. The frame base plate 4 is also equipped with 4 feet (the height of the feet should be higher than the height of the door from the table when the door is fully open) to support the frame base plate 4. When the door plate 442 is opened, as the C-shaped claw rotates, one end of the door plate 442 will rotate to the lower part of the frame base plate 4, thereby saving space.

[0042] In a preferred embodiment, the reagent tray 18 includes a semi-circular tray body 181, and the tray body 181 is provided with a sample hole 182, a sampling needle support 183, a quality control liquid hole 184, a diluent hole 185, and a plurality of detection holes 186; a concave first notch 1811 is provided on the non-arc side of the tray body 181, and a first buckle 1812 is connected to one side wall of the first notch 1811; a second buckle 1813 is also connected to the arc-shaped side wall of the tray body 181; and a positioning post 1814 is provided at the bottom of the tray body 181.

[0043] In this embodiment, the disk body 181 has a semi-circular structure. The sample port 182 on the disk body 181 is used to hold the sample to be tested, the sampling needle holder 183 is used to hold the sampling needle, the quality control liquid port 184 is used to hold the quality control liquid, the detection port 186 is used for reagent storage and detection after the sample and reagent are mixed and reacted, and the diluent port 185 is used to hold the diluent. Simultaneously, the disk body 181 is also provided with a latch and a positioning post 1814. The latch is used to fix the reagent disk 18 to the reagent tray 17 of the biochemical analyzer, and the positioning post 1814... The column 1814 is used for positioning on the reagent tray 17. Preferably, the non-arc side of the tray body 181 has a concave first notch 1811. A first buckle 1812 is connected to one side wall of the first notch 1811. The first buckle 1812 has a V-shaped structure and is designed with the first notch 1811, which facilitates the placement and removal of the reagent tray 18. A second buckle 1813 is also connected to the arc-shaped side wall of the tray body 181. The second buckle 1813 has a long strip structure. The first buckle 1812 and the second buckle 1813 can be respectively attached to the tray on the device. The corresponding locking positions in tray 17 are secured to ensure that the reagent tray 18 will not shake during agitation and mixing. Furthermore, the positioning post 1814 at the bottom of tray 181 engages with the holes on tray 17, allowing for guidance and positioning when the reagent tray 18 is placed. After the reagent tray 18 encapsulates the relevant reagents in the corresponding holes, an aluminum film is heat-sealed onto the surface. (Traditional tray 17 has an inner cavity; the reagent tray 18 is installed within the inner cavity of tray 17. Two limiting holes are provided on the outer side of tray 17, and two bosses are provided in the middle of tray 17. When the reagent tray 18…) After the reagent tray 18 is placed in the tray 17, the second buckle 1813 on the outer side of the reagent tray 18 is engaged in the limiting hole and the first buckle 1812 at the inner notch of the reagent tray 18 is engaged in the boss. Since the material of the reagent tray 18 is a high molecular polymer material, such as transparent PC, PPS, etc., the buckle has good elasticity, so the reagent tray 18 can be locked in the tray 17. Therefore, when the reagent tray 18 is mixed with the tray 17 at a high frequency, the reagent tray 18 will not shake relative to the tray 17, thus avoiding affecting the test results.

[0044] In a preferred embodiment, both the sample well 182 and the control liquid well 184 are conical in shape, with a larger opening and a smaller lower portion. This allows the sampling needle to easily draw the liquid from the bottom of the sample well 182 and the control liquid well 184, ensuring that the solution is fully utilized.

[0045] In a preferred embodiment, the lower part of the sampling needle holder 183 is a conical sealing hole, and the upper part of the sampling needle holder 183 is a cylindrical hole, with the opening size of the cylindrical hole matching the outer diameter of the sampling needle. The sampling needle holder 183 is divided into two parts: the lower part of the body is a conical sealing hole, and the upper part is a cylindrical hole. The cylindrical opening size matches the outer dimensions of the sampling needle, so that the reagent tray 18 will not shake when it is shaken, and it is also convenient for the pipette 32 to pick up the sampling needle. After the sampling needle has finished sampling and adding the sample, the sampling needle is retrieved in the holder, and the residual liquid of the sampling needle will drip into the hole of the holder, and thus be retrieved together with the reagent tray 18. Otherwise, the residual liquid of the sampling needle will drip onto the mounting plate of the equipment, which may easily cause contamination or even corrosion of the equipment.

[0046] In a preferred embodiment, the detection hole 186 has a square structure; the upper part of the detection hole 186 is a non-optical area, and the lower part of the detection hole 186 is an optical detection area, and the draft angle of the upper part of the detection hole 186 is greater than the draft angle of the lower part of the detection hole 186. The detection hole 186 is generally square, and the detection hole 186 is divided into an optical area and a non-optical area. The upper part is the non-optical area, which has a larger draft angle to facilitate mold injection molding, and the lower part is the optical detection area, which has a smaller draft angle to effectively reduce light flux loss.

[0047] In a preferred embodiment, the diluent hole 185 has an arc-shaped structure, and one end of the bottom of the diluent hole 185 is provided with a flow guide step 1851, while the other end of the bottom of the diluent hole 185 is a bottom hole 1852 with a conical structure. The surface of the flow guide step 1851 has an arc-shaped structure that slopes downward toward the bottom hole 1852, and the surface of the flow guide step 1851 is larger than the bottom surface. The diluent hole 185 is arc-shaped, with a flow guide step 1851 at one end. The surface of the flow guide step 1851 is larger than the bottom surface, and the surface of the flow guide step 1851 has a certain draft angle along the water direction. The hole on the bottom surface is conical, with a very small bottom surface and a large opening connected to the flow guide step 1851. When the liquid is almost used up, the liquid will flow along the surface of the flow guide step 1851 into the conical hole, thereby facilitating the sampling needle to draw up the liquid at the bottom of the diluent hole 185, so that the diluent solution can be fully utilized.

[0048] In a preferred embodiment, the sample well 182, sampling needle holder 183, control solution well 184, detection well 186, and diluent well 185 are arranged in an arc, with the center of each well concentric with the center of the tray 181. In this embodiment, there is one sample well 182, one sampling needle holder 183, one control solution well 184, and one diluent well 185, with the remaining positions filled with detection wells 186. In this embodiment, there are 12 detection wells 186. Because the detection wells 186 are arranged in an arc shape, their number can be set to be large, and two reagent trays 18 can be placed on one tray 17 at the same time. Therefore, this solution can perform a large number of detection items, and the space of the detection wells 186 is sufficient, resulting in a large detection throughput and stable and reliable detection results. The reagents in the detection wells 186 of the reagent tray 18 in this solution are encapsulated with lyophilized reagents, which is based on the principle of dry biochemical analyzer; it is convenient to transport and store, and can be stored and transported at room temperature.

[0049] In a preferred embodiment, the pipette 32 includes a pipetting base plate 321, a lifting drive mechanism 322, a cylinder 323, a piston rod 324, a plug 325, and a first sliding seat 326. The first sliding seat 326 is slidably connected to the pipetting base plate 321, and the output end of the lifting drive mechanism 322 is connected to the first sliding seat 326. The cylinder 323 is mounted on the pipetting base plate 321, one end of the piston rod 324 is movably inserted into the inner cavity of the cylinder 323, and the other end of the piston rod 324 is connected to the first sliding seat 326. The plug 325 is mounted on the bottom of the cylinder 323, and the bottom of the plug 325 also has an inner hole communicating with the inner cavity of the cylinder 323. The lower outer wall of the plug 325 also has an outwardly protruding limiting step 3251. A pipetting mounting plate 328 connected to the Z-axis lifting mechanism 31 is also mounted on the pipetting base plate 321.

[0050] In this embodiment, a pipetting mounting plate 328 connected to the pipetting base plate 321 is also included. The pipetting mounting plate 328 is used to connect to the Z-axis lifting mechanism 31, which can drive the pipette 32 to move up and down. The output end of the lifting drive mechanism 322 is connected to the first sliding seat 326 to drive the first sliding seat 326 to slide in the vertical direction. The piston rod 324 is slidably connected to the inner cavity of the cylinder 323 in the vertical direction. The top end of the piston rod 324 is exposed outside the cylinder 323 and connected to the first sliding seat 326. A third sealing ring 3232 (O-ring) is also provided between the cylinder 323 and the piston rod 324 to ensure that there is no air leakage between them, thereby improving the accuracy of liquid aspiration and dissipation. The lifting drive mechanism 322 can drive the first sliding seat 326 to move upward and pull the piston rod 324, thereby forming a negative pressure cavity between the piston rod 324 and the inner cavity of the cylinder 323, thereby realizing liquid aspiration.

[0051] In addition, a plug 325 is provided at the bottom of the cylinder 323. The plug 325 has an inner hole that communicates with the inner cavity of the cylinder 323. A fourth sealing ring 3233 (O-ring) is also provided between the plug 325 and the cylinder 323 to ensure that there is no air leakage between them, thereby improving the accuracy of liquid suction and discharge. The outer diameter of the plug 325 is interference-fitted with the sampling needle orifice. The plug 325 is also provided with a limiting step 3251. Preferably, the limiting step 3251 is cylindrical and the side wall of the cylinder is an outwardly convex arc structure.

[0052] When the sampling needle in the reagent tray 18 moves below the pipette 32, the pipette 32 moves downward under the drive of the lifting drive mechanism 322 until the plug 325 is fully engaged with the mouth of the sampling needle. At this time, the end of the sampling needle is limited by the limiting step 3251 of the plug 325, and the pipette 32 stops moving downward, thus completing the picking up of the sampling needle. Then, the sampling needle and the pipette 32 can be used to transfer and aspirate the sample, reagent and diluent in the reagent tray 18. At the same time, the end of the sampling needle is set as a tip, which can pierce the aluminum film heat-sealed on the surface of the reagent tray 18. After the pipette 32 picks up the sampling needle, under the drive of the lifting drive mechanism 322, the sampling needle first pierces the aluminum film and then transfers and aspirates the liquid.

[0053] In a preferred embodiment, a push block 327 is further included; the push block 327 includes an annular portion 3271 and a fixing portion 3272; the annular portion 3271 has an internally hollow structure and is coaxially and movably sleeved on the plug 325; one end of the fixing portion 3272 is connected to the outer wall of the annular portion 3271, and the other end of the fixing portion 3272 is also connected to a guide post 3273; a C-shaped notch 3231 is also provided on one side of the cylinder body 323, and one end of the guide post 3273 passes through the C-shaped notch 3231 and moves out from the top of the cylinder body 323 to be arranged below the first sliding seat 326; a limiting block 3274 is also installed on the guide post 3273 near the lower end of the C-shaped notch 3231, and a spring 3275 is also sleeved on the guide post 3273 between the top of the limiting block 3274 and the upper end of the C-shaped notch 3231. Meanwhile, the push block 327 also includes a baffle 3276 connected to the outer wall of the annular portion 3271; the lower part of the pipetting base plate 321 is also equipped with a limit switch 3277, and the baffle 3276 is correspondingly set with the notch of the limit switch 3277. Preferably, the baffle 3276 is set on one side of the annular portion 3271 and is set at 90° with the fixing portion 3272. The limit switch 3277 is a U-shaped photoelectric sensor. The annular portion 3271 is hollow inside and fits with the outer diameter of the plug 325. The annular portion 3271 can move up and down along the outer diameter of the plug 325.

[0054] Before the pipette 32 picks up the sampling needle, the spring 3275 is in a stretched state. Under the force of the spring 3275, the limiting block 3274 on the guide post 3273 is always in contact with the bottom surface of the lower end of the C-shaped notch 3231 of the cylinder 323. At this time, the push block 327 is away from the bottom surface of the cylinder 323, and the annular part 3271 of the push block 327 partially blocks the plug 325. At the same time, the baffle 3276 on the push block 327 also disengages from the notch of the limit switch 3277, and the light of the limit switch 3277 illuminates, indicating that the sampling needle has not yet been picked up. When the pipette 32 moves down to pick up the sampling needle, under the force of the lifting drive mechanism 322, the end of the sampling needle forcibly pushes the push block 327 upward until the end of the sampling needle is in contact with the limiting step 325 of the plug 325. When the sampler is flush with the top surface of the pusher 327, the top surface of the pusher 327 is flush with the bottom surface of the cylinder 323. At the same time, the guide post 3273 is pushed upward, the spring 3275 is compressed, and the limit block 3274 on the guide post 3273 moves away from the bottom surface of the C-shaped notch 3231. Simultaneously, the baffle 3276 on the pusher 327 is pushed into the notch of the limit switch 3277, and the light on the limit switch 3277 goes out. The photoelectric signal generated at this time is sent to the control panel 45, and the background control system will determine that the sampler has been correctly picked up. Then the system will issue an instruction to perform the next action. Therefore, the pipette 32 of this application can automatically detect whether the sampler has been correctly picked up, without the need to design a separate detection mechanism to detect whether the sampler has been picked up in place, thus saving costs.

[0055] After the test is completed, the sampling needle needs to be retracted back into the sampling needle holder 183 hole of the reagent tray 18. Driven by the lifting drive mechanism 322, the first sliding seat 326 moves down, thereby causing the piston rod 324 to move down. At this time, a positive pressure is formed on the liquid in the sampling needle, and the liquid is squeezed into the corresponding hole of the reagent tray 18. The piston rod 324 continues to move down, and all the liquid in the sampling needle will be squeezed out. When the first sliding seat 326 continues to push the piston rod 324 down, the first sliding seat 326 will apply a downward pressure to the top of the guide post 3273, pushing the push block 327 to move down, thereby pushing the sampling needle off the plug 325.

[0056] In a preferred embodiment, the lifting drive mechanism 322 includes a motor bracket 3221 connected to one side of the pipetting base plate 321, a drive motor 3222 mounted on the motor bracket 3221, and a lead screw and nut assembly 3223 connected to the output shaft of the drive motor 3222; the first sliding seat 326 is connected to the lead screw and nut assembly 3223; a first guide rail 3224 is also arranged vertically on the upper part of the other side of the pipetting base plate 321, and the cylinder 323 is mounted on the lower part of the other side of the pipetting base plate 321; a guide sliding hole 3225 is also provided vertically on the upper part of the other side of the pipetting base plate 321; one end of the first sliding seat 326 is slidably connected to the first guide rail 3224, and the other end of the first sliding seat 326 moves through the guide sliding hole 3225 and is connected to the lead screw and nut assembly 3223.

[0057] The lifting drive mechanism 322 adopts a motor lead screw transmission method. Driven by the drive motor 3222, the first sliding seat 326 can be driven to reciprocate on the first guide rail 3224 via the lead screw nut assembly 3223. Preferably, two guide sliding holes 3225 are provided side by side on the pipetting base plate 321. The first sliding seat 326 is divided into two parts. One part is slidably connected to the first guide rail 3224, and the other part moves through the two guide sliding holes 3225 and is connected to the lead screw nut assembly 3223. Thus, the drive motor 3222 and the cylinder 323 can be symmetrically arranged from left to right, which greatly reduces the height of the pipette 32, thereby making the space utilization rate higher and the equipment smaller.

[0058] In addition, a barcode scanner 51 is also provided on the fixed bracket 5. A QR code is affixed to the reagent tray 18. Before the experiment, the barcode scanner 51 scans and identifies the QR code on the reagent tray 18 to read the information of the reagent tray 18, such as serial number, project name, production information, etc., and then records this information into the test program.

[0059] The working process of this invention is as follows: S1: Start the biochemical analyzer and operate the equipment through the control panel 45 to make the reaction device 1 exit the chamber in the horizontal direction. At this time, the chamber door 442 opens. First, put the sampling needle into the sampling needle support 183 hole of the reagent tray 18, then insert the reagent tray 18 into the tray 17 along the mounting groove, and then add the sample into the sample hole 182 of the reagent tray 18. S2: Operate the equipment via the control panel 45 to make the reaction device 1 enter the chamber in the horizontal direction and reach the predetermined position. At this time, the chamber door 442 automatically closes, all moving components are reset, and the barcode scanner 51 reads the information on the reagent tray 18. S3: Start the test operation by operating the equipment through the control panel 45. The rotary motor drives the reagent tray 18 to rotate. When the sampling needle on the reagent tray 18 rotates to the bottom of the pipette 32, the plug 325 of the pipette 32 is aligned with the sampling needle, and the pipette 32 moves down to pick up the sampling needle. S4: The reagent tray 18 continues to rotate, and the pipette 32 uses the sampling needle to puncture the heat-sealed aluminum film on the detection hole 186 in sequence, and then punctures the heat-sealed aluminum film on the diluent hole 185. S5: The sampling needle draws the diluent from the diluent hole 185, and then injects the diluent into each detection hole 186 in sequence. Next, the diluent is injected into the sample hole 182, and the liquid in the sample hole 182 is mixed by suction and expulsion. S6: The sampling needle draws the diluted sample solution from the sample well 182, and then injects the sample solution into each detection well 186 in sequence; S7: The rotary motor then drives the reagent tray 18 to rotate. When the sampling needle holder 183 on the reagent tray 18 rotates to the position directly below the pipette 32, the sampling needle of the pipette 32 is aligned with the hole of the sampling needle holder 183, and the pipette 32 will retract the sampling needle back into the reagent tray 18. S8: Then the rotating motor rotates in both directions at high frequency to mix the reagent and sample solution in the detection well 186; S9: Next, the reaction incubation begins. The photodiode 146 periodically detects the light intensity passing through the detection hole 186 and converts the light signal into an electrical signal. The data is then transmitted to an external processor, where the test results are obtained through data processing and finally displayed on the screen of the control panel 45. S10: The experiment is completed. The reaction device 1 exits the chamber in a horizontal direction. At this time, the chamber door is opened, and the reagent tray 18 and the sampling needle are removed from the tray 17 and discarded.

[0060] The above are merely preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A fully automatic biochemical analyzer characterized by comprising: The application relates to a reaction device, a detection device, and a sampling transfer device arranged above the reaction device; the reaction device comprises a detection base plate, a rotary driving mechanism, and a light source assembly; the rotary driving mechanism is installed on the detection base plate, and the rotary driving mechanism is further drivingly connected with a tray for carrying a reagent disc; the top of the detection base plate is further provided with an incubation assembly at a position corresponding to the rotary driving mechanism, the tray and the reagent disc carried by the tray are located in the incubation assembly; the light source assembly is installed on the detection base plate and located in the incubation assembly, and the incubation assembly is further provided with a light outlet at a position corresponding to one end of the light source assembly for light emission; the detection device comprises a detection assembly and a fiber assembly; the detection assembly is installed on the detection base plate, and the fiber assembly is connected between the detection assembly and the light outlet.

2. The fully automatic biochemical analyzer according to claim 1, characterized in that, The incubation assembly comprises a supporting column connected to one end of the top of the detection base plate, a heating base plate installed on the supporting column, and a blocking ring installed on the heating base plate; the heating base plate and the blocking ring are both annular in structure, and the bottom of the heating base plate is further provided with a heating film; the light outlet is arranged in the side wall of the blocking ring; the light source assembly comprises a light source base and a light emitting element; the light source base is installed on the detection base plate and located in the blocking ring; one end of the light source base is provided with a first installation cavity, and the light emitting element is installed in the first installation cavity; one side of the light source base is further provided with an optical channel penetrating into the first installation cavity and corresponding to the light outlet, and a first lens is further installed in the optical channel; one side of the light source base is further provided with a lens cover plate for pressing and limiting the first lens in the optical channel; the light emitting element comprises a lamp holder and a halogen tungsten lamp fixed on the lamp holder; a first sealing ring is further embedded in the optical channel, and one side of the lens cover plate is further provided with a limiting boss inserted into the optical channel and used for pressing and limiting the first sealing ring and the first lens; the rotary driving mechanism comprises a first motor installed on the bottom of the detection base plate, and the output shaft of the first motor is further drivingly connected with a connecting shaft sleeve; the connecting shaft sleeve is located in the blocking ring, and the tray is connected with the connecting shaft sleeve.

3. The fully automatic biochemical analyzer according to claim 2, characterized in that, The fiber assembly comprises a main fiber head, a first fiber pressing plate, and a plurality of detection fibers; one end of the plurality of detection fibers is gathered into a bundle and integrated in the main fiber head, and the other end of each detection fiber is further provided with a pair of fiber heads; the main fiber head is installed in the light outlet, and the fiber heads are connected with the detection assembly; the first fiber pressing plate is installed on the side wall of the blocking ring and used for limiting and fixing the main fiber head; the main fiber head is internally axially hollow; the main fiber head comprises a first cylindrical part, a second cylindrical part and a third cylindrical part which are coaxially arranged and integrally connected in sequence; the first cylindrical part is inserted into the light outlet; the first fiber pressing plate is further provided with a first stepped hole and a second stepped hole communicated with the first stepped hole; the second cylindrical part is clamped in the first stepped hole, and the third cylindrical part is clamped in the second stepped hole; one side of the first fiber pressing plate is further provided with a first gap penetrating into the first stepped hole and the second stepped hole.

4. The fully automatic biochemical analyzer according to claim 3, characterized in that, The detection assembly comprises a detection support connected to the other end of the top of the detection base plate, an optical mounting seat mounted on the detection support, a second optical fiber pressing plate connected to one side of the optical mounting seat, and a detection PCB plate connected to the other side of the optical mounting seat; a plurality of first mounting holes are arranged on one side of the optical mounting seat in the length direction and are spaced apart, a plurality of second mounting holes are further arranged on the other side of the optical mounting seat, and each second mounting hole is in communication with a first mounting hole; the sub-fiber head of each detection optical fiber is correspondingly inserted into a first mounting hole, and a filter is further mounted in each second mounting hole; one side of the detection PCB plate is further provided with a plurality of photodiodes, and each photodiode is correspondingly inserted into a second mounting hole; the sub-fiber head has an internal axial hollow structure; the sub-fiber head comprises a fourth cylindrical part and a fifth cylindrical part which are coaxially arranged and integrally connected; the fourth cylindrical part is inserted into the first mounting hole; the bottom of the second optical fiber pressing plate has a sawtooth structure, and the circular arc between each adjacent two sawteeth is correspondingly clamped on the fifth cylindrical part of a sub-fiber head; a second sealing ring is further embedded in the second mounting hole, and the second sealing ring is located between the photodiode and the filter.

5. The fully automatic biochemical analyzer according to claim 1, characterized in that, It also comprises a rack base plate and a fixing support connected to the rack base plate; a first translation mechanism is arranged on the top of the rack base plate along the length direction, and the first translation mechanism is further driven to be connected with a first translation seat; the detection base plate is connected to the top of the first translation seat; the sampling transfer device comprises a Z-axis lifting mechanism mounted on the upper part of one side of the fixing support and a pipettor connected with the Z-axis lifting mechanism; the pipettor is arranged above the tray; a code scanner is further mounted on the middle part of the fixing support.

6. The fully automatic biochemical analyzer according to claim 5, wherein The pipettor comprises a pipetting base plate, a lifting driving mechanism, a cylinder, a piston rod, a plug, and a first sliding seat; the first sliding seat is slidingly connected to the pipetting base plate, and the output end of the lifting driving mechanism is connected to the first sliding seat; the cylinder is mounted on the pipetting base plate, one end of the piston rod is movably inserted into the inner cavity of the cylinder, and the other end of the piston rod is connected to the first sliding seat; the plug is mounted on the bottom of the cylinder, and an inner hole in communication with the inner cavity of the cylinder is arranged on the bottom of the plug; an outwardly protruding limiting step is further arranged on the lower part of the outer wall of the plug; a pipetting mounting plate connected with the Z-axis lifting mechanism is further mounted on the pipetting base plate.

7. The fully automatic biochemical analyzer according to claim 6, characterized in that, The pipettor further comprises a push block; the push block comprises a circular ring part and a fixing part; the circular ring part has an internal axial hollow structure, and the circular ring part is coaxially movably sleeved on the plug; one end of the fixing part is connected to the outer wall of the circular ring part, and the other end of the fixing part is further connected with a guide column; a C-shaped notch is further arranged on one side of the cylinder, one end of the guide column passes through the C-shaped notch and movably penetrates out from the top of the cylinder to be arranged below the sliding block; a limiting block is further mounted on the lower end of the guide column close to the C-shaped notch, and a spring is further sleeved on the guide column between the top of the limiting block and the upper end of the C-shaped notch; the push block further comprises a baffle connected to the outer wall of the circular ring part; a limiting switch is further mounted on the lower part of the pipetting base plate, and the baffle and the notch of the limiting switch are correspondingly arranged.

8. The fully automatic biochemical analyzer according to claim 1, characterized in that, The reagent disc comprises a disc body in a semicircular configuration, and the disc body is provided with a sample hole, a sampling needle support, a quality control liquid hole, a diluent hole and a plurality of detection holes; a first notch is arranged on the non-arc side of the disc body, and a first buckle is connected to the side wall of the first notch; a second buckle is further connected to the arc side wall of the disc body; and a positioning column is further arranged at the bottom of the disc body.

9. The fully automatic biochemical analyzer according to claim 5, wherein The rack bottom plate is further connected with a shell, and the fixing support is located in the shell; a feed opening is further arranged at the lower part of one end of the shell, and a warehouse door assembly is further arranged at the feed opening; and a control screen is further rotatably connected to the top end of the shell; and the reaction device is arranged close to the feed opening.

10. The fully automatic biochemical analyzer according to claim 9, characterized in that, The warehouse door assembly comprises a fixed plate, a warehouse door plate and a warehouse door support; the fixed plate is mounted on the rack bottom plate, and the fixed plate is provided with a first groove and a second groove, and the second groove is arranged on one side of the first groove; two end portions of the first groove are respectively provided with a rotating shaft support, and one end of each rotating shaft support extends into the second groove; one end of the rotating shaft support is further rotatably connected with a rotating shaft; the warehouse door plate is arranged in the feed opening, the warehouse door support is mounted on one side of the warehouse door plate, and two connecting claws are further connected to the warehouse door support; one end of each connecting claw is respectively connected with a rotating shaft; a torsional spring is further arranged on the rotating shaft, and two ends of the torsional spring are respectively connected with the rotating shaft support and the connecting claw; a first top block is mounted on one end of the detection bottom plate facing the warehouse door plate, and a second top block is further mounted on one end of the first translation seat facing the warehouse door plate.

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