Molecular marker used as Tibetan sheep marker assisted selection and related to disease resistance character and application of molecular marker

By detecting SNP molecular markers in Tibetan sheep, the problem of assessing disease resistance traits has been solved, enabling early screening of individuals with superior disease resistance and improving the breeding efficiency of Tibetan sheep.

CN121780718APending Publication Date: 2026-04-03LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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Patent Information

Application Number
CN202610116026.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-28
Publication Date
2026-04-03

AI Technical Summary

Technical Problem

The lack of molecular markers in existing technologies for assessing disease resistance traits in Tibetan sheep leads to low breeding efficiency, and traditional breeding methods cannot quickly screen out individuals with superior disease resistance at the young age.

Method used

This invention provides a Tibetan sheep SNP molecular marker located at 29,402,282 bases on chromosome 10 of the international sheep reference genome Oar_v4.0 version, with a variant type of T/C. By detecting the genotype of this SNP locus, PCR amplification and sequencing are performed using primers to analyze the levels of IL-1α, IL-1β, IL-6, TNF-α, IL-1Ra, and IL-10 in individual Tibetan sheep, providing a kit for auxiliary selection of disease resistance traits.

Benefits of technology

By detecting the genotype at nucleotide 29,402,282 on chromosome 10 of Tibetan sheep, the immune capacity of individual Tibetan sheep can be determined, providing SNP molecular marker resources for early molecular breeding and improving breeding efficiency.

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Abstract

The invention provides a molecular marker used for Tibetan sheep marker-assisted selection and related to disease resistance characters and application of the molecular marker, and belongs to the technical field of molecular marker-assisted breeding, the molecular marker is located at the 29402282th basic group on the 10th chromosome of the international sheep reference genome Oarv4.0 version; the variation type is T / C, the molecular marker site has three genotypes of TT, TC and CC, the genotype of the molecular marker site has significant correlation with the content of cytokines in a Tibetan sheep blood sample, and the content of IL-1alpha, IL-1beta, IL-6, TNF-alpha, IL-1Ra and IL-10 of a Tibetan sheep individual can be judged by detecting the genotype of the SNP molecular marker. The SNP molecular marker can be used for non-diagnostic Tibetan sheep immune trait marker-assisted selection, and a new SNP molecular marker resource is provided for early molecular breeding of Tibetan sheep.
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