Raw material mixing machine for dapagliflozin tablet production

Abstract

The invention relates to the technical field of raw material mixing machines, and provides a raw material mixing machine for dapagliflozin tablet production, which comprises a case, a support outer cylinder is movably arranged on the case, a support baffle plate is detachably arranged at the opening of the support outer cylinder, a mixing inner cylinder is detachably arranged in the support outer cylinder and is coaxially arranged with the outer cylinder, and the support baffle plate is detachably arranged at the opening of the support outer cylinder. The two ends of the mixing inner cylinder are rotationally connected to the inner bottom wall of the supporting outer cylinder and the supporting baffle respectively; the locking piece is arranged on the supporting outer cylinder and / or the supporting baffle and is used for limiting the rotation of the mixing inner cylinder. According to the raw material mixing machine for dapagliflozin tablet production, the multi-direction operation advantage of a three-dimensional mixing machine is reserved, the inner cylinder and the outer cylinder are coaxially and rotatably connected and matched with the driving assembly, forward and reverse rotation and rotation speed adjustment of the inner cylinder relative to the outer cylinder are achieved, the mixing strength is accurately controlled, the inner cylinder can be taken out from the opening only by disassembling the supporting baffle during replacement, and the replacement is convenient. The problem that the cylinder body is inconvenient to disassemble is solved, the mixing inner cylinders with different volumes can be replaced according to the production scale, and mixing of multi-specification materials is compatible.

Description

Technical Field

[0001] This invention relates to the field of raw material mixing technology, and specifically to a raw material mixing machine for the production of dapagliflozin tablets. Background Technology

[0002] Dapagliflozin tablets, as an antidiabetic drug, have a raw material system mainly consisting of the active pharmaceutical ingredient (dapagliflozin), fillers, disintegrants, glidants, and lubricants. The preparation process usually involves first premixing the prescribed amounts of dapagliflozin, fillers, and disintegrants, and then adding the prescribed amounts of glidants and lubricants to the premix to obtain a total mixture. The total mixture is then directly compressed and coated to obtain dapagliflozin tablets.

[0003] In the above preparation process, a three-dimensional motion mixer is basically used to complete the mixing operation. During operation, the mixing cylinder has multi-directional rotation, which accelerates the flow and diffusion of various materials during the mixing process. At the same time, it avoids the material segregation and accumulation caused by centrifugal force in general mixers to a certain extent, thus achieving mixing without dead corners.

[0004] However, there are still some details that need improvement when using a three-dimensional motion mixer to mix dapagliflozin tablets according to the above-mentioned preparation process. Specifically: the loading rate of the mixing cylinder is only 30%~50%, and it lacks forced shear force, which results in insufficient embedding of the active pharmaceutical ingredient into the interparticle gaps of the filler, and the mixing uniformity needs to be improved; the mixing intensity of the mixing cylinder cannot be adjusted in multiple dimensions (it only has high and low speed and three-dimensional motion, two dimensions), which may lead to uneven distribution of the lubricant even when adding a flow aid, affecting the quality of the finished product, as the lubricant is added later and the mixing time is strictly required (over-mixing will cause the lubricant to form a complete hydrophobic film on the particle surface, hindering tablet disintegration and drug dissolution; under-mixing will cause the tablets to stick during compression); the three-dimensional motion mixer itself also has the problem of inconvenience in disassembling and replacing the mixing cylinder. Summary of the Invention

[0005] To overcome the above-mentioned defects, embodiments of the present invention provide a raw material mixer for the production of dapagliflozin tablets, which solves the technical problems of limited mixing intensity adjustment dimensions of three-dimensional motion mixers in related technologies, which may lead to uneven distribution of lubricant, affecting the quality of finished products, and the inconvenience of disassembling and replacing the mixing cylinder.

[0006] At least one embodiment of the present invention provides a raw material mixer for the production of dapagliflozin tablets, comprising: The chassis has a movable supporting outer cylinder, and the end of the supporting outer cylinder has an opening. A supporting baffle is detachably installed at the opening. The mixing inner cylinder is detachably installed inside the supporting outer cylinder and is coaxially arranged with the supporting outer cylinder. The two ends of the mixing inner cylinder are respectively rotatably connected to the bottom wall of the supporting outer cylinder and the supporting baffle. A drive assembly, disposed on the inner wall of the supporting outer cylinder, is used to drive the mixing inner cylinder to rotate. The drive assembly includes: A support ring is provided on the inner wall of the outer support cylinder, and the inner mixing cylinder passes through the support ring and forms an annular gap with the inner wall of the support ring. Several support frames are arranged on the support ring and along the circumference. The support frames are located within the annular interval. Each support frame is equipped with a drive wheel and a drive motor for driving the drive wheel. The drive wheel is used to press against the outer wall of the mixing inner cylinder so that the drive wheel can drive the mixing inner cylinder to rotate.

[0007] According to one embodiment of this application, a supporting protrusion is provided at the center of the inner bottom wall of the supporting outer cylinder. The supporting protrusion penetrates the bottom surface of the mixing inner cylinder and is rotatably connected to the mixing inner cylinder. The system also includes: The stirring shaft is located inside the mixing inner cylinder. One end of the stirring shaft is engaged with the support protrusion, and the other end is rotatably connected to the top wall of the mixing inner cylinder. After the mixing inner cylinder rotates, the stirring shaft can rotate relative to the mixing inner cylinder.

[0008] According to one embodiment of this application, a stirring shaft is provided with a plurality of stirring parts, which are arranged at intervals along the axial direction of the stirring shaft.

[0009] According to one embodiment of this application, the stirring shaft is provided with a material feeding part, which abuts against the inner wall of the mixing inner cylinder, and the mixing inner cylinder has a discharge port near the opening. When the mixing inner cylinder rotates to discharge material, the material feeding part can feed the material toward the discharge port.

[0010] According to one embodiment provided in this application, According to one embodiment of this application, a plurality of strip grooves are provided on the support ring. The plurality of strip grooves are arranged along the circumference and correspond one-to-one with a plurality of support frames. The length direction of each strip groove is arranged along the radial direction of the support ring. The support frame and the strip groove slide in fit to adapt to the outer wall of the mixing inner cylinder of different diameters. A raw material mixer for the production of dapagliflozin tablets also includes: The compression spring is located in the strip groove. The two ends of the compression spring act on the support frame and the support ring respectively. The compression spring can provide the force for the drive wheel to press against the outer wall of the mixing inner cylinder.

[0011] According to one embodiment of this application, there are at least two drive components, and several drive components are arranged at intervals along the axial direction of the supporting outer cylinder.

[0012] According to one embodiment of this application, the opening is circular, the support baffle is a strip plate and is arranged along the diameter of the opening, and both ends of the support baffle are detachably connected to the outer wall of the outer support cylinder, and one end of the mixing inner cylinder is rotatably connected to the support baffle.

[0013] According to one embodiment provided in this application, it further includes: A locking element is provided on the outer support cylinder and / or the support baffle to lock the relative position of the mixing inner cylinder and the outer support cylinder; The mixing inner cylinder can drive the material to follow the supporting outer cylinder in three-dimensional motion, and can also drive the material to rotate circumferentially relative to the supporting outer cylinder.

[0014] According to one embodiment of this application, the locking member is detachably mounted on the support baffle and penetrates the support baffle. The end cap of the mixing inner cylinder is provided with a locking hole, and the locking member can be inserted into the locking hole to restrict the rotation of the mixing inner cylinder.

[0015] According to one embodiment of this application, the side of the chassis is provided with two rotating shafts. The two rotating shafts are symmetrically arranged and arranged horizontally. Each rotating shaft is hinged to a rocker arm at the end away from the chassis. Each rocker arm has a U-shaped connecting part. The two ends of the supporting outer cylinder are perpendicular to the hinge shafts of the two U-shaped connecting parts, so that the supporting outer cylinder can move in three dimensions relative to the chassis under the drive of the rotating shafts.

[0016] This invention provides a raw material mixer for dapagliflozin tablet production. Compared with existing technologies, it retains the multi-directional operation advantages of traditional three-dimensional mixers by using a structure where the outer supporting cylinder is movably mounted on the machine casing and the inner mixing cylinder is coaxial with the outer supporting cylinder. This enriches the material flow and diffusion patterns. Furthermore, the drive assembly built into the inner wall of the outer supporting cylinder can drive the inner mixing cylinder to rotate relative to the outer supporting cylinder, providing a core carrier for the subsequent superimposed forced shearing structure (stirring shaft). Forced shearing force is generated through the relative movement of the inner cylinder and the stirring shaft, fully embedding dapagliflozin into the interparticle gaps of fillers such as lactose and microcrystalline cellulose. This also adds the adjustment dimension of "independent forward and reverse rotation of the inner mixing cylinder and the speed of the inner mixing cylinder." Furthermore, the inner mixing cylinder can be locked in place relative to the outer supporting cylinder by a locking component, further adding the adjustment dimension of "whether the inner mixing cylinder rotates independently," and adapting to the overall preparation process. In the premixing stage, the inner cylinder speed can be reduced (or the inner cylinder rotation can be restricted by locking components), and the initial dispersion of dapagliflozin and filler can be achieved solely by the three-dimensional movement of the outer cylinder, avoiding high-speed shearing that causes dapagliflozin to float. In the total mixing stage (after adding lubricant), the inner cylinder speed can be increased, or it can be controlled by reciprocating forward and reverse rotation. The rotation of the inner cylinder enhances the uniform dispersion of the lubricant, precisely controls the mixing intensity, and ensures uniform distribution of the lubricant.

[0017] Furthermore, the traditional three-dimensional mixer has a complex connection structure between the mixing cylinder and the main body of the equipment (the two ends of the outer wall of the mixing cylinder are directly connected to the two rocker arms on the mixer, which is quite complicated and inconvenient to disassemble). Therefore, it is divided into inner and outer cylinders. The mixing operation is completed by the inner mixing cylinder, and the outer supporting cylinder is connected to the mixer. The mixing inner cylinder is detachably installed inside the outer supporting cylinder, and a simplified structure is adopted to achieve the detachable design. Specifically, the two ends of the mixing inner cylinder are rotatably connected only through the bottom wall of the outer supporting cylinder and a detachable support baffle. On this basis, the support baffle is located at the opening at the end of the outer supporting cylinder. Therefore, when replacing the inner cylinder, only the support baffle needs to be removed, and the inner cylinder can be directly taken out from the opening, solving the problem of the mixing cylinder being inconvenient to disassemble. At the same time, it can be compatible with the mixing of materials of different specifications, and the mixing inner cylinder with different solvents can be replaced according to the scale, without replacing the entire set of equipment. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the structure of a raw material mixer for the production of dapagliflozin tablets provided in an embodiment of the present invention; Figure 2 This is an embodiment of the present invention. Figure 1 Diagram showing the fit between the outer support cylinder and the inner mixing cylinder; Figure 3 This is an embodiment of the present invention. Figure 1 Cross-sectional view of the outer supporting cylinder and the inner mixing cylinder; Figure 4 This is an embodiment of the present invention. Figure 1 State diagram of the driving component driving the hybrid inner cylinder; Figure 5 This is an embodiment of the present invention. Figure 4 Enlarged view of section A in the middle; Figure 6 This is an embodiment of the present invention. Figure 2 A magnified view of a portion of the image; Figure 7 This is an embodiment of the present invention. Figure 1 A magnified view of a portion of the image.

[0020] In the diagram: 1. Chassis; 2. Supporting outer cylinder; 201. Opening; 202. Supporting protrusion; 3. Supporting baffle; 4. Mixing inner cylinder; 401. Discharge port; 402. Locking hole; 5. Drive assembly; 501. Support ring; 502. Annular gap; 503. Support frame; 504. Drive wheel; 505. Strip groove; 6. Locking component; 7. Stirring shaft; 8. Compression spring; 9. Rotating shaft; 10. Rocker arm; 1001. U-shaped connection. Detailed Implementation

[0021] To make the objectives, technical solutions, and advantages of this application clearer, the technical solutions in the embodiments of this application will be described in more detail below with reference to the accompanying drawings. In the drawings, the same or similar reference numerals denote the same or similar components or components having the same or similar functions throughout. The described embodiments are some, but not all, embodiments of this application. The embodiments described below with reference to the accompanying drawings are exemplary and intended to explain this application, and should not be construed as limiting this application. All other embodiments obtained by those skilled in the art based on the embodiments of this application without creative effort are within the scope of protection of this application.

[0022] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, an indirect connection through an intermediate medium, or the internal communication between two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0023] In the description of this application, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application.

[0024] The terms "first," "second," "third," "fourth," etc., used in the specification, claims, and accompanying drawings of this application are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged where appropriate so that the embodiments of this application described herein can be implemented, for example, in a sequence other than those illustrated or described herein.

[0025] To make the drawings concise and easy to understand, some drawings only show one of the components with the same structure or function, or only one of them is marked. In this article, "one" not only means "only one", but can also mean "more than one", and "several" includes "two" and "more than two".

[0026] Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not necessarily limited to those explicitly listed, but may include other steps or units not explicitly listed or inherent to such processes, methods, products, or apparatus. It is understood that the specific embodiments described herein are merely illustrative of the invention and not intended to limit it. The embodiments of this application are described in detail below with reference to the accompanying drawings.

[0027] Definition: The inner top wall of the mixing inner cylinder is its inner end face near the supporting baffle, located at the top of the mixing inner cylinder; the inner bottom wall of the mixing inner cylinder is its inner end face near the inner bottom wall of the supporting outer cylinder, located at the bottom of the mixing inner cylinder.

[0028] The core of the preparation process for dapagliflozin tablets lies in achieving uniform dispersion of the raw material system through precise mixing. In the premixing stage: First, according to the prescription ratio, a small dose of dapagliflozin active pharmaceutical ingredient, fillers (such as lactose and microcrystalline cellulose), and disintegrants (such as crospovidone) are added to the mixing cylinder of a three-dimensional motion mixer (defined as a combined motion of rotation around a horizontal axis and oscillation around a vertical axis). After closing the cylinder's sealing cover, the equipment is started to make the mixing cylinder perform multi-directional combined motion (such as a combination of rotation and oscillation). Utilizing the material convection and diffusion effects generated by the motion, the initial accumulation state of the materials is broken, resulting in a premixed material. In the final mixing stage: After premixing is completed... The prescribed amount of glidant (such as silica) and lubricant (such as magnesium stearate) are added to the mixing cylinder through the feeding port of the equipment. The three-dimensional motion mixer is restarted and the cylinder continues to rotate in multiple directions to ensure that the glidant, lubricant and premix are fully contacted and evenly dispersed. The glidant needs to cover the surface of the material particles to reduce the friction between particles, and the lubricant needs to form a uniform thin coating to avoid sticking during tableting. Therefore, the mixing time needs to be strictly controlled at this stage (the specifics are not the point of this application, so they are not elaborated in detail). After the final mixing is completed, the mixture is discharged from the discharge port 401 of the cylinder and directly enters the tableting process. After tableting and coating, dapagliflozin tablets are obtained.

[0029] The three-dimensional motion mixer mainly consists of a chassis 1, a transmission system, a mixing cylinder, a support and connection mechanism, and a control system. The chassis 1 provides a fixed support foundation for the equipment and integrates the power drive components inside. The transmission system is responsible for converting the motor power into multi-directional motion of the mixing cylinder. The mixing cylinder is the core chamber for material mixing and is usually designed with a sealed structure to avoid material leakage and dust pollution. The support and connection mechanism is used to connect the chassis 1 and the mixing cylinder to ensure motion stability. The control system realizes the start and stop of the equipment, speed adjustment, and running time control.

[0030] Specifically, such as Figure 1 , Figure 7 As shown, the chassis 1 is the basic support component of the whole machine, with a vertical frame structure. The top is reserved with symmetrical mounting positions to support subsequent moving parts. Its core function is to provide a stable mounting benchmark for supporting the outer cylinder 2. At the same time, it integrates a power transmission and control system to provide a power source for the three-dimensional movement of the outer cylinder 2. The motor in the chassis 1 transmits power to two symmetrically arranged rotating shafts 9 on its top through the transmission system. The two are arranged in a horizontal direction. Each rotating shaft 9 has a rocker arm 10 hinged at the end away from the chassis 1. The rocker arm 10 is T-shaped in general. It has a U-shaped connecting part 1001 integrally formed at the end away from the chassis 1, which facilitates the penetration and rotatable connection of the shaft part through the U-shaped connecting part 1001. Thus, the shaft part can be hinged to the outer cylinder 2. That is, the two ends of the outer wall of the outer cylinder 2 are respectively rotatably connected to the two U-shaped connecting parts 1001 one by one, so that the outer cylinder 2 can perform reciprocating three-dimensional hybrid motion under the drive of the rotating shaft 9.

[0031] The core advantage of the three-dimensional motion mixer lies in the multi-directional composite motion of the mixing cylinder. This composite motion subjectes the material inside the cylinder to continuously changing gravity and inertial forces, constantly generating movements such as tumbling, interpenetration, and diffusion. This not only avoids the specific gravity segregation caused by centrifugal force (such as stratification of dapagliflozin and filler due to density differences), but also covers all areas inside the cylinder, achieving "mixing without dead angles".

[0032] Furthermore, to address the technical problems of limited mixing intensity adjustment dimensions in related technologies' three-dimensional motion mixers, which may lead to uneven lubricant distribution, affecting finished product quality, and making it inconvenient to disassemble and replace the mixing cylinder, an embodiment of the present invention provides a raw material mixer for dapagliflozin tablet production, such as... Figure 1 , Figure 2 As shown, it includes a chassis 1 and a supporting outer cylinder 2. The supporting outer cylinder 2 is a cylindrical body with an opening 201 at one end. The opening 201 is circular. The opening 201 has connecting parts integrally formed at both ends along the diameter. The two ends of the supporting baffle 3 are respectively bolted to the two connecting parts to realize the detachable connection of the supporting baffle 3. The outer cylinder 2 has a hollow cavity inside, with a pre-drilled mounting slot for the drive assembly 5 on its inner wall. A support structure for rotatably connecting the inner mixing cylinder 4 is located at the center of the inner bottom wall, ensuring that the inner mixing cylinder 4 is coaxial with the outer cylinder after installation. Specifically, for example... Figure 3 As shown, a cylindrical support protrusion 202 can be integrally formed at the center of the bottom wall of the outer support cylinder 2. The support protrusion 202 penetrates the bottom surface of the mixing inner cylinder 4 and is rotatably connected to the mixing inner cylinder 4. The support baffle 3 is a long strip plate, the length of which is slightly larger than the diameter of the opening 201. It is installed along the diameter direction of the opening 201 and has a rotatable connecting seat at the center of its bottom for forming a rotatable connection with the top of the mixing inner cylinder 4. After removing the support baffle 3, the mixing inner cylinder 4 can be directly replaced. The support baffle 3 not only achieves axial positioning of the mixing inner cylinder 4, but also does not affect its rotation.

[0033] The mixing inner cylinder 4 is similar to the supporting outer cylinder 2, and is a cylindrical cavity structure with an outer diameter smaller than the inner diameter of the supporting outer cylinder 2. There is an annular space between the two for installing the drive component 5. The top of the mixing inner cylinder 4 is provided with a rotating shaft head that cooperates with the rotating connecting seat, and the bottom end directly cooperates with the supporting protrusion 202 to form a coaxial rotating connection structure.

[0034] like Figure 2 As shown, the drive assembly 5 for driving the rotation of the mixing inner cylinder 4 is embedded in the annular space and bolted to the inner wall of the supporting outer cylinder 2, specifically it can be installed in the reserved installation slot; the locking member 6 is provided on the supporting outer cylinder 2 and / or the supporting baffle 3 to restrict the rotation of the mixing inner cylinder 4; for example, the supporting baffle 3 is provided with a pin-type locking member 6, which is inserted into the locking hole 402 of the mixing inner cylinder 4 to restrict the rotation; for another example, the inner wall of the supporting outer cylinder 2 is provided with an elastic claw-type locking member 6 to clamp the outer wall of the inner cylinder to prevent circumferential rotation; for another example, the above two are used together.

[0035] This embodiment retains the multi-directional operation advantages of traditional three-dimensional mixers. Through the structure of supporting the outer cylinder 2 and the coaxial mixing inner cylinder 4, and with the drive component 5 supporting the inner wall of the outer cylinder 2, the mixing inner cylinder 4 can independently rotate forward and backward and adjust its speed, providing a mounting carrier for the stirring shaft 7. The relative movement between the inner cylinder and the stirring shaft 7 generates forced shearing force, which fully embeds dapagliflozin into the gaps between the filler particles. At the same time, a new adjustment dimension of "whether the inner cylinder rotates independently" is added. During the premixing stage, the speed can be reduced or the inner cylinder can be locked to prevent dapagliflozin from floating. During the total mixing stage, the speed can be increased or the rotation can be reversed to precisely control the mixing intensity and ensure uniform dispersion of the lubricant. It adopts an inner and outer double cylinder design. The two ends of the mixing inner cylinder 4 are rotatably connected through the inner bottom wall of the supporting outer cylinder 2 and the detachable support baffle 3. When replacing, only the support baffle 3 needs to be removed to take out the inner cylinder from the opening 201, solving the problem of inconvenient disassembly of traditional mixing cylinders. Moreover, mixing inner cylinders of different volumes can be replaced according to the production scale, which is compatible with the mixing of multiple specifications of materials without replacing the entire set of equipment.

[0036] refer to Figure 3 and Figure 5 In some embodiments, the drive assembly 5 includes a support ring 501, several support frames 503, and several drive wheels 504. The support ring 501 serves as the mounting reference for the entire drive assembly 5 and is an annular structure. It is fixed to the inner wall of the outer support cylinder 2 by bolts or welding and is coaxial with the mixing inner cylinder 4. Its inner diameter is larger than the outer diameter of the mixing inner cylinder 4, so that after the mixing inner cylinder 4 passes through the support ring 501, an annular gap 502 is formed between the two. The support frames 503 are L-shaped or U-shaped bracket structures, and there are 3-4 of them, arranged along the circumference of the support ring 501. The components are evenly distributed and all located within the annular interval 502. The bottom of each support frame 503 is slidably or fixedly connected to the support ring 501, and a drive wheel 504 is reserved at the top. It is a cylindrical roller made of rubber or polyurethane and the surface can be provided with anti-slip texture. It is rotatably connected to the top of the support frame 503 through a rotating shaft. Its wheel surface is tightly fitted to the outer wall of the mixing inner cylinder 4 and the mounting position of the drive motor used to drive the drive wheel 504 to rotate. Then, the drive wheel 504 rotates under the drive of the drive motor, and drives the mixing inner cylinder 4 to rotate around its own axis through friction.

[0037] In this embodiment, multiple drive wheels 504 are evenly distributed along the circumference of the mixing inner cylinder 4 to form a multi-point uniform force, avoiding the problem of uneven force and eccentric operation caused by a single drive point, and ensuring the smooth rotation of the mixing inner cylinder 4; and the whole is embedded in the annular spacer 502, with a compact structure that does not interfere with each other, and can be adapted to mixing inner cylinders 4 of different diameters by adjusting the installation position of the support frame 503 or the size of the drive wheels 504.

[0038] As a specific embodiment, the support ring 501 is provided with several strip grooves 505. The strip grooves 505 are through groove structures on the end face of the support ring 501, and the number is the same as that of the support frame 503. The strip grooves 505 are arranged circumferentially and correspond one-to-one with several support frames 503. The length direction of each strip groove 505 is set along the radial direction of the support ring 501. The bottom of the support frame 503 is integrally formed with a sliding block that is adapted to the strip groove 505. The surface of the sliding block is treated with wear resistance (such as spraying titanium nitride coating) to reduce sliding friction loss. The compression spring 8 is installed in the strip groove 505, and its two ends act on the sliding block and the inner wall of the strip groove 505 respectively, ensuring that the force of the compression spring 8 is transmitted radially along the groove, ensuring that there is no loosening after assembly. The spring axis is consistent with the length direction of the strip groove 505 to ensure accurate force direction and avoid lateral force, which would cause the support frame 503 to jam.

[0039] This embodiment achieves adaptive fitting of inner cylinders of various specifications. Through the elastic telescopic design of the "strip groove 505 + compression spring 8," the drive wheel 504 can be flexibly adjusted radially. There is no need to replace the support ring 501 or drive assembly 5; only the inner cylinder needs to be replaced to meet the production needs of different batches. Specifically: disassemble the support baffle 3, loosen the connecting bolts between the two ends of the support baffle 3 and the outer wall of the support outer cylinder 2, remove the baffle, and take out the old inner cylinder: directly pull the old mixing inner cylinder 4 out from the opening 201 of the support outer cylinder 2. After pulling it out, push... The support frame 503 slides inward along the strip groove 505, and the compression spring 8 extends; insert the new inner cylinder: push the new mixing inner cylinder 4 of the appropriate specification into the supporting outer cylinder 2 from the opening 201. The outer wall of the new mixing inner cylinder 4 presses against the drive wheel 504 and pushes the support frame 503, compressing the compression spring 8 until the two ends of the inner cylinder are aligned with the inner bottom wall of the supporting outer cylinder 2 and the baffle installation position, respectively. Finally, install the supporting baffle 3 and tighten the bolts so that the two ends of the inner cylinder form a rotation support. The compression spring 8 automatically rebounds, and the drive wheel 504 presses against the outer wall of the new inner cylinder to complete the replacement.

[0040] In addition, the elastic compensation design of the compression spring 8 in this embodiment can avoid hard contact between the drive wheel 504 and the outer wall of the mixing inner cylinder 4, reduce wear, and ensure that the drive wheel 504 continuously presses against the outer wall of the mixing inner cylinder 4. Since the mixing inner cylinder 4 is coaxial and rotatably connected with the supporting outer cylinder 2, it will not be affected by the unstable swaying of the circumferential compression spring 8, and will only be driven by the drive wheel 504 to complete the rotation.

[0041] As a specific embodiment, there are at least two drive components 5. Several drive components 5 are arranged at intervals along the axial direction of the supporting outer cylinder 2, which can distribute the drive load, reduce the wear rate of individual components, and stably drive the mixing inner cylinder 4 to rotate.

[0042] As a parallel implementation, the drive assembly 5 can adopt a gear meshing structure supporting the inner bottom wall of the outer cylinder 2; specifically, at one end of the mixing inner cylinder 4 near the inner bottom wall of the supporting outer cylinder 2, a ring gear (the outer diameter of the gear is smaller than the outer diameter of the mixing inner cylinder 4) is coaxially fixedly installed, and a motor-driven drive gear or gear set is arranged around the support protrusion 202 on the inner bottom wall of the supporting outer cylinder 2 and meshes with the ring gear. An annular protective cover (fixed to the inner bottom wall of the supporting outer cylinder 2) is set outside the gear meshing area, and the inner wall of the protective cover is attached to the outer side of the gear, with only the gear meshing opening 201 reserved. Compared with the friction drive of the drive wheel 504 mentioned above, the gear meshing transmission has no slippage phenomenon, the power transmission efficiency is higher, and it can adapt to the mixing requirements of higher loads.

[0043] refer to Figure 6In some embodiments, the locking member 6 is installed in the non-central area of ​​the support baffle 3. It can be a structure such as a pin. After penetrating the support baffle 3, it can extend into the locking hole 402 at the end cap of the mixing inner cylinder 4, which can restrict the rotation of the inner cylinder. When unlocking, the locking member 6 only needs to be pulled out from the locking hole 402, which is convenient to operate.

[0044] Referring to Figure 3, in some embodiments, a stirring shaft 7 is added, which is a cylindrical solid shaft. One end is fixedly engaged with the support protrusion 202 through a spline or polygonal snap-fit ​​structure so that there is relative movement between the stirring shaft 7 and the rotating mixing inner cylinder 4. The other end is rotatably connected to the inner top wall of the mixing inner cylinder 4 through a bearing. Thus, when the mixing inner cylinder 4 rotates, the stirring shaft 7 drives the various components on it, such as the stirring part and the feeding part, to exert a forced shearing effect on dapagliflozin and disperse it evenly into the filler system.

[0045] Regarding the mixing section, a blade-type structure can be adopted, integrally formed with the mixing shaft 7 or welded and fixed. The edges are rounded to avoid scraping the inner wall of the inner cylinder or damaging the material particles. Several mixing sections are evenly spaced along the axial direction of the mixing shaft 7. The material feeding section is located at one end of the mixing shaft 7 near the opening 201 of the mixing inner cylinder 4. It is an arc-shaped scraper structure. The arc of the scraper is completely in contact with the inner wall of the inner cylinder, ensuring contact with the inner wall of the inner cylinder without generating metal friction. Because the side wall of the mixing inner cylinder 4 near the opening 201 has a rectangular or arc-shaped discharge port 401, after the mixing inner cylinder 4 has completed mixing, it stops rotating when the discharge port 401 is facing downwards. Then, the drive component 5 is started to drive the inner cylinder to rotate continuously. At this time, the mixing shaft 7 and the supporting outer cylinder 2 are fixed together. The material feeding section on it moves relative to the inner wall as the inner cylinder rotates, scraping the inner wall of the inner cylinder and pushing the material adhering to the wall and the material in the cylinder towards the discharge port 401. Finally, the material is smoothly discharged through the discharge port 401, achieving efficient discharge without residue.

[0046] The above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit them. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application, and should all be included within the protection scope of this application.

Claims

1. A raw material mixer for the production of dapagliflozin tablets, characterized in that, include: A chassis (1) is provided with a supporting outer cylinder (2), the end of which has an opening (201), and a supporting baffle (3) is detachably provided at the opening (201). The mixing inner cylinder (4) is detachably disposed inside the supporting outer cylinder (2) and coaxially disposed with the supporting outer cylinder (2). The two ends of the mixing inner cylinder (4) are respectively rotatably connected to the inner bottom wall of the supporting outer cylinder (2) and the supporting baffle (3). A drive assembly (5), which is disposed on the inner wall of the supporting outer cylinder (2) and is used to drive the mixing inner cylinder (4) to rotate, the drive assembly (5) comprising: Support ring (501) is provided on the inner wall of the outer support cylinder (2), and the mixing inner cylinder (4) passes through the support ring (501) and forms an annular gap (502) with the inner wall of the support ring (501). A plurality of support frames (503) are provided on the support ring (501) and arranged along the circumference. The plurality of support frames (503) are located within the annular interval (502). Each support frame (503) is rotatably provided with a drive wheel (504) and is provided with a drive motor for driving the drive wheel (504). The drive wheel (504) is used to press against the outer wall of the mixing inner cylinder (4) so ​​that the drive wheel (504) can drive the mixing inner cylinder (4) to rotate.

2. The raw material mixer for dapagliflozin tablet production according to claim 1, characterized in that, The outer supporting cylinder (2) has a supporting protrusion (202) at the center of its inner bottom wall. The supporting protrusion (202) penetrates the bottom surface of the inner mixing cylinder (4) and is rotatably connected to the inner mixing cylinder (4). It also includes: A stirring shaft (7) is located inside the mixing inner cylinder (4), with one end of the stirring shaft (7) being engaged with the support protrusion (202) and the other end being rotatably connected to the inner top wall of the mixing inner cylinder (4). After the mixing inner cylinder (4) rotates, the stirring shaft (7) can rotate relative to the mixing inner cylinder (4).

3. The raw material mixer for dapagliflozin tablet production according to claim 2, characterized in that, The stirring shaft (7) is provided with a plurality of stirring parts, and the plurality of stirring parts are arranged at intervals along the axial direction of the stirring shaft (7).

4. The raw material mixer for dapagliflozin tablet production according to claim 2, characterized in that, The stirring shaft (7) is provided with a material feeding part, which abuts against the inner wall of the mixing inner cylinder (4), and the mixing inner cylinder (4) has a discharge port (401) at one end near the opening (201). When the mixing inner cylinder (4) rotates to discharge material, the material feeding part can push the material toward the discharge port (401).

5. The raw material mixer for dapagliflozin tablet production according to claim 1, characterized in that, The support ring (501) is provided with a plurality of strip grooves (505), which are arranged along the circumference and correspond one-to-one with a plurality of support frames (503). The length direction of each strip groove (505) is arranged along the radial direction of the support ring (501). The support frame (503) slides with the strip groove (505) to adapt to the outer wall of the mixing inner cylinder (4) of different diameters. The raw material mixer for dapagliflozin tablet production also includes: Compression spring (8) is provided in the strip groove (505). The two ends of the compression spring (8) act on the support frame (503) and the support ring (501) respectively. The compression spring (8) can provide the driving wheel (504) to press against the outer wall of the mixing inner cylinder (4).

6. The raw material mixer for dapagliflozin tablet production according to claim 1, characterized in that, There are at least two drive components (5), and several drive components (5) are arranged at intervals along the axial direction of the supporting outer cylinder (2).

7. The raw material mixer for dapagliflozin tablet production according to claim 1, characterized in that, The opening (201) is circular, the support baffle (3) is a strip plate and is set along the diameter of the opening (201), and both ends of the support baffle (3) are detachably connected to the outer wall of the support outer cylinder (2), and one end of the mixing inner cylinder (4) is rotatably connected to the support baffle (3).

8. A raw material mixer for the production of dapagliflozin tablets according to claim 7, characterized in that, Also includes: Locking element (6), which is provided on the supporting outer cylinder (2) and / or the supporting baffle (3) for locking the relative position of the mixing inner cylinder (4) and the supporting outer cylinder (2); The mixing inner cylinder (4) can drive the material to follow the supporting outer cylinder (2) in three-dimensional motion, and can drive the material to rotate circumferentially relative to the supporting outer cylinder (2).

9. A raw material mixer for the production of dapagliflozin tablets according to claim 8, characterized in that, The locking member (6) is detachably mounted on the support baffle (3) and passes through the support baffle (3). The end cap of the mixing inner cylinder (4) is provided with a locking hole (402). The locking member (6) can be inserted into the locking hole (402) to restrict the rotation of the mixing inner cylinder (4).

10. A raw material mixer for the production of dapagliflozin tablets according to claim 1, characterized in that, The side of the chassis (1) is provided with two rotating shafts (9). The two rotating shafts (9) are symmetrically arranged and arranged horizontally. Each rotating shaft (9) has a rocker arm (10) hinged at one end away from the chassis (1). Each rocker arm (10) has a U-shaped connecting part (1001). The two ends of the supporting outer cylinder (2) are perpendicular to the hinge shafts of the two U-shaped connecting parts (1001) to enable the supporting outer cylinder (2) to perform three-dimensional movement relative to the chassis (1) under the drive of the rotating shafts (9).

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