Storage device for mesenchymal stem cell exosomes

Abstract

The invention relates to a storage device, in particular to a storage device for mesenchymal stem cell exosomes. The invention provides a storage device for mesenchymal stem cell exosomes, which is stable in rotation and can be taken out according to the storage time of test tubes. A mesenchymal stem cell exosome storage device comprises a frame, connecting rings, a refrigerator and the like, an annular groove is formed in the bottom in the frame, the five connecting rings are evenly placed on the annular groove, and the refrigerator is installed in the middle of the bottom in the frame. The motor is automatically closed every 72-degree rotation, after a certain test tube rotates to the tray, the threaded rod can be rotated through resetting of the rack, the test tube is driven to be pushed upwards and taken out more accurately, the motor always rotates in the same direction, the later stored exosome is taken out after defecation, and the newly stored exosome is taken out firstly, so that the operation is more accurate. The exosome in a certain test tube is prevented from losing activity after being taken out for a long time.

Description

Technical Field

[0001] This invention relates to a storage device, and more particularly to a storage device for mesenchymal stem cell exosomes. Background Technology

[0002] Mesenchymal stem cells are a type of pluripotent stem cell that possesses all the common characteristics of stem cells, namely, self-renewal and multi-lineage differentiation capabilities. Clinically, they are used to treat hematological diseases, cardiovascular diseases, cirrhosis, nervous system diseases, repair of partial meniscectomy injuries in the knee joint, and autoimmune diseases. When performing exosome manipulation, it is important to conduct the procedure in a low-temperature environment and minimize the number of repeated freeze-thaw cycles. Therefore, after culturing mesenchymal stem cell exosomes, the exosomes are generally stored in a storage device at -80°C for long-term preservation.

[0003] A storage device for mesenchymal stem cell exosomes, disclosed in CN114044239A, includes a low-temperature chamber. The chamber is connected to a rotating motor, a sliding base plate, a linear motor, a connecting block, a lid, and a label drawer. The rotating motor includes an output shaft, which is fixedly connected to a storage tray. The storage tray is connected to a test tube clamp, through which storage test tubes are inserted. The linear motor includes an output lead screw, which is connected to a lifting plate. Both the sliding base plate and the lifting plate have arc-shaped grooves. The connecting block is connected to an insulation partition, which has a test tube outlet. An outlet cover is connected to the insulation partition, and a handle is connected to the lid. This device solves the problem in existing exosome storage devices where all test tubes containing exosomes are exposed to room temperature when a particular test tube is retrieved, leading to repeated freeze-thaw cycles of the exosomes. It is suitable for storing exosomes. While the aforementioned patent can prevent other test tubes containing exosomes from being exposed to room temperature when a particular test tube is retrieved, it is difficult to ensure that the test tube is accurately rotated onto the lifting plate when the rotating motor is used to rotate a particular test tube. This can easily lead to errors and is not very convenient to use. If the rotating motor runs for too long, the corresponding test tube will be missed, and all test tubes need to be rotated once more to complete the process. Furthermore, it cannot accurately retrieve the test tubes based on the storage time of the exosomes.

[0004] To address the above issues, further improvements are needed in storage devices. A storage device for mesenchymal stem cell exosomes that is rotationally stable and can be retrieved based on the length of time the test tube has been stored is required. Summary of the Invention

[0005] To overcome the shortcomings of existing storage devices, such as insufficient precision in retrieving test tubes and inability to retrieve them based on the length of test tube storage time, the technical problem to be solved is to provide a storage device for mesenchymal stem cell exosomes that is rotationally stable and can be retrieved based on the length of test tube storage time.

[0006] The technical solution of the present invention is as follows: a storage device for mesenchymal stem cell exosomes, comprising a frame, connecting rings, a cooler, a cover plate, a rotating mechanism, a clamping mechanism, and a lifting mechanism. An annular groove is opened at the bottom of the frame, and five connecting rings are evenly placed on the annular groove. A cooler is installed in the middle of the bottom of the frame. A slot is opened on the front side of the top of the frame, and two cover plates are engaged in the slot. The two cover plates are in contact with each other. A rotating mechanism is provided in the middle of the frame, and a clamping mechanism is provided on the rotating mechanism. The clamping mechanism can limit the position of the test tube. A lifting mechanism is provided at the bottom of the frame.

[0007] As a preferred technical solution of the present invention, the rotating mechanism includes a motor, a rotating frame, lifting rods and U-shaped rods. The motor is located in the middle of the upper part of the frame, and the rotating frame is connected to the output shaft of the motor. Five lifting rods are uniformly slidable in a circular manner along the circumference of the rotating frame. Each lifting rod has a U-shaped rod at its bottom, and each U-shaped rod is connected to a connecting ring on the same side.

[0008] As a preferred embodiment of the present invention, the clamping mechanism includes a connecting block, a rotating block, and a torsion spring. Each lifting rod is provided with a connecting block at its top, and two rotating blocks are rotatably provided on each connecting block. A torsion spring is connected between each rotating block and the lower part of the connecting block on the same side. Each rotating block has a semi-circular groove, and the semi-circular grooves between each pair of corresponding rotating blocks form a circular groove. The circular grooves between each pair of corresponding rotating blocks are in contact with the test tube on the same side. The outer wall of the rotating block is a smooth surface.

[0009] As a preferred embodiment of the present invention, the lifting mechanism includes a guide rod, a rack, a ring spring, a fixed rod, a protrusion, a compression spring, a threaded rod, a one-way gear, and a tray. A guide rod is located on the bottom left front side of the frame, and a rack is slidably mounted on the guide rod. A ring spring connects the rack and the guide rod. A fixed rod is located on the right rear side of the rack. Both the fixed rod and the rack are located inside the frame. A protrusion is slidably mounted on the rear side of the fixed rod, and a compression spring connects the protrusion and the interior of the fixed rod. A U-shaped rod can contact the protrusion by rotation. A threaded rod is rotatably mounted on the bottom front side of the frame, and a one-way gear is located at the lower part of the threaded rod. A tray is slidably connected to the lower part of the threaded rod at the position above the one-way gear. The tray contacts the U-shaped rod. The rack can mesh with the one-way gear by rotation. A guide rod is connected to the bottom front side of the frame, and the guide rod and the tray are slidably connected.

[0010] As a preferred embodiment of the present invention, it further includes a reset mechanism capable of limiting the position of the cover plate. The reset mechanism includes a fixed block, a connecting shaft, a slider, a connecting spring, and a reset spring. Fixed blocks are symmetrically arranged on the left and right sides of the top front side of the frame. Sliders are slidably arranged on the inner side of both fixed blocks. A connecting spring is connected between each slider and the fixed block on the same side. A connecting shaft is arranged on the top rear side of both cover plates. Both connecting shafts are slidably connected to the sliders on the same side. A reset spring is connected between each connecting shaft and the slider on the same side.

[0011] As a preferred embodiment of the present invention, it also includes a buffer mechanism that can prevent test tube breakage. The buffer mechanism includes a buffer pad and a buffer spring. The buffer pad is slidably provided at the bottom of the frame, and the buffer pad is connected to the bottom of the frame by a buffer spring.

[0012] As a preferred technical solution of the present invention, it also includes a placement mechanism that can temporarily store test tubes, thereby freeing up the hands. The placement mechanism includes a placement rack and silicone blocks. The placement rack is provided on the rear side of the top of the frame, and five silicone blocks are evenly arranged on the placement rack. The silicone blocks are used to temporarily store test tubes.

[0013] As a preferred embodiment of the present invention, the inner wall of each connecting ring is coated with anti-slip adhesive.

[0014] This invention provides a storage device for mesenchymal stem cell exosomes, which has the following advantages: 1. The motor automatically shuts off every 72 degrees. After a test tube is rotated onto the tray, the screw rod can be rotated by the reset of the rack, which will push the test tube upward to remove it. This is more precise. The motor rotates in one direction, so the exosomes stored later are removed later and the exosomes newly stored are removed first, avoiding the loss of activity of exosomes in a test tube if they are not removed for a long time. 2. This device clamps the test tube with a rotating block, which can prevent the test tube from tipping over during rotation and increase safety; 3. When opening the cover, by moving the cover upward, the cover is disengaged from the slot, and under the action of the return spring, the cover will automatically rotate outward and unfold, making the operation simpler and faster. It can also limit the cover to prevent it from being placed randomly after being removed. 4. The cushioning pad prevents the test tubes from shaking and breaking due to vibration when people place the device, making it safer; 5. When people are handling test tubes containing exosomes, the test tubes can be temporarily placed on a silicone block to avoid having nowhere to put the test tubes and improve their practicality. Attached Figure Description

[0015] Figure 1 This is a three-dimensional structural diagram of the present invention.

[0016] Figure 2 This is a first partial cross-sectional view of the present invention.

[0017] Figure 3 This is a second partial cross-sectional view of the present invention.

[0018] Figure 4 This is a three-dimensional structural diagram of the rotating mechanism of the present invention.

[0019] Figure 5 This is a three-dimensional structural diagram of the clamping mechanism of the present invention.

[0020] Figure 6 This is a three-dimensional structural diagram of the clamping mechanism of the present invention.

[0021] Figure 7 This is a three-dimensional structural diagram of the lifting mechanism of the present invention.

[0022] Figure 8 This is a partial cross-sectional three-dimensional structural schematic diagram of the lifting mechanism of the present invention.

[0023] Figure 9 This is a three-dimensional structural diagram of the reset mechanism of the present invention.

[0024] Figure 10 This is a partial cross-sectional view of the reset mechanism of the present invention.

[0025] Figure 11 This is a three-dimensional structural diagram of the buffer mechanism of the present invention.

[0026] Figure 12 This is a three-dimensional structural diagram of the placement mechanism of the present invention.

[0027] The components in the diagram are labeled as follows: 1-Frame, 2-Connecting ring, 3-Test tube, 4-Refrigerator, 5-Cover plate, 6-Rotating mechanism, 60-Motor, 61-Rotating frame, 62-Lifting rod, 63-U-shaped rod, 7-Clamping mechanism, 70-Connecting block, 71-Rotating block, 72-Torsion spring, 8-Lifting mechanism, 80-Guide rod, 81-Rack, 82-Ring spring, 83-Fixing rod, 84-Protrusion, 85-Compression spring, 86-Threaded rod, 87-One-way gear, 88-Tray, 9-Reset mechanism, 90-Fixing block, 91-Connecting shaft, 92-Slider, 93-Connecting spring, 94-Reset spring, 10-Buffer mechanism, 100-Buffer pad, 101-Buffer spring, 11-Placement mechanism, 110-Placement rack, 111-Silicone block. Detailed Implementation

[0028] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments, but this does not limit the scope of protection and application of the present invention. Example 1

[0029] A storage device for mesenchymal stem cell exosomes, in Figures 1-3The diagram shows a frame 1, connecting rings 2, a cooler 4, a cover plate 5, a rotating mechanism 6, a clamping mechanism 7, and a lifting mechanism 8. The bottom of the frame 1 has an annular groove on which five connecting rings 2 are evenly placed. The inner wall of each connecting ring 2 is coated with anti-slip adhesive, which increases the stability of the test tube 3. The cooler 4 is installed in the middle of the bottom of the frame 1. A slot is opened on the front top of the frame 1, and two cover plates 5 are engaged in the slot, with the two cover plates 5 in contact with each other. A rotating mechanism 6 is provided in the middle of the frame 1 to allow the test tube 3 to rotate. A clamping mechanism 7 is provided on the rotating mechanism 6 to clamp the test tube 3. A lifting mechanism 8 is provided at the bottom of the frame 1.

[0030] exist Figure 1 , Figure 2 and Figure 4 As shown, the rotating mechanism 6 includes a motor 60, a rotating frame 61, lifting rods 62 and U-shaped rods 63. The motor 60 is bolted to the middle of the upper part of the frame 1. The rotating frame 61 is connected to the output shaft of the motor 60. Five lifting rods 62 are evenly slidably arranged in a ring along the circumference of the rotating frame 61. Each lifting rod 62 has a U-shaped rod 63 at its bottom. Each U-shaped rod 63 is connected to the connecting ring 2 on the same side.

[0031] exist Figure 2 , Figure 5 and Figure 6 As shown, the clamping mechanism 7 includes a connecting block 70, a rotating block 71, and a torsion spring 72. Each lifting rod 62 has a connecting block 70 at its top. Each connecting block 70 has two rotating blocks 71 that can clamp the test tube 3. Each rotating block 71 is connected to the lower part of the connecting block 70 on the same side with a torsion spring 72. Each rotating block 71 has a semi-circular groove. The semi-circular grooves between each pair of corresponding rotating blocks 71 form a circular groove. The circular groove between each pair of corresponding rotating blocks 71 contacts the test tube 3 on the same side. The outer wall of the rotating block 71 is a smooth surface.

[0032] exist Figure 2 , Figure 7 and Figure 8As shown, the lifting mechanism 8 includes a guide rod 80, a rack 81, a ring spring 82, a fixed rod 83, a protrusion 84, a compression spring 85, a threaded rod 86, a one-way gear 87, and a tray 88. A guide rod 80 is located on the bottom left front side of the frame 1. A rack 81 is slidably mounted on the guide rod 80. A ring spring 82 connects the rack 81 to the guide rod 80. A fixed rod 83 is welded to the right rear side of the rack 81. Both the fixed rod 83 and the rack 81 are located inside the frame 1. A protrusion 84 is slidably mounted on the rear side of the fixed rod 83. The protrusion 84 is connected to... A compression spring 85 is connected inside the fixed rod 83. The U-shaped rod 63 can contact the protrusion 84 by rotation. A threaded rod 86 is rotatably provided on the bottom front side of the frame 1. A one-way gear 87 is keyed to the lower part of the threaded rod 86. A tray 88 that can push the test tube 3 upward is slidably connected to the lower part of the threaded rod 86. The tray 88 is located above the one-way gear 87 and contacts the U-shaped rod 63. The rack 81 can mesh with the one-way gear 87 by rotation. A guide rod is connected to the bottom front side of the frame 1. The guide rod and the tray 88 are slidably connected.

[0033] Initially, test tubes 3 are evenly placed on the five connecting rings 2, and each test tube 3 contains exosomes derived from mesenchymal stem cells. The cooler 4 is in operation, maintaining the internal temperature of the frame 1 at -80℃. When the exosomes need to be removed, the two cover plates 5 are opened first, then the motor 60 is started. The motor 60, after adjustment, can only rotate 72 degrees at a time. The rotation of the motor 60's output shaft drives the rotating frame 61 to rotate, which in turn drives the lifting rod 62 and the U-shaped rod 63 to rotate. The rotation of the U-shaped rod 63 simultaneously drives the connecting rings 2 and the test tubes 3 to rotate. The rotation of the lifting rod 62 and the test tubes 3 also drives the rotating block 71 to rotate. The rotating block 71 clamps the test tubes 3, preventing them from tipping over during rotation. One of the U-shaped rods 63 rotates to... When the protrusion 84 contacts, it will push the protrusion 84 and the fixed rod 83 to rotate, causing the fixed rod 83 to drive the rack 81 to rotate along the guide rod 80. The annular spring 82 will be compressed accordingly. Since the one-way gear 87 is unidirectional, the rotation of the rack 81 will mesh with the one-way gear 87, causing the one-way gear 87 to rotate freely. The threaded rod 86 will not rotate. After the annular spring 82 is compressed to its limit, the U-shaped rod 63 continues to rotate, which will squeeze the protrusion 84, causing the compression spring 85 to be compressed. In this way, the protrusion 84 will no longer block the corresponding U-shaped rod 63, and the corresponding U-shaped rod 63 will continue to rotate. After the output shaft of the motor 60 rotates to 72 degrees, the motor 60 will automatically shut off. In this way, the corresponding U-shaped rod 63 will rotate to contact the tray 88, and the protrusion 84 will disengage from the corresponding U-shaped rod 63. Upon contact, rack 81, under the reset action of ring spring 82, drives fixed rod 83 and protrusion 84 to rotate in the opposite direction and reset. At the same time that protrusion 84 disengages from U-shaped rod 63, protrusion 84 moves upward and resets under the reset action of compression spring 85. The reverse rotation of rack 81 drives one-way gear 87 and threaded rod 86 to rotate, thereby driving tray 88 to move upward. This causes tray 88 to drive the corresponding U-shaped rod 63 and the test tube 3 to be taken to move upward, thereby driving the corresponding lifting rod 62 to move upward. The corresponding lifting rod 62 then drives the clamping mechanism 7 to move upward as a whole. The corresponding rotating block 71 clamps the test tube 3 to be taken at this time. The test tube 3 moves upward and passes through the slot. Because the circular slot formed by the two semi-circular slots is smooth, it is easy for people to pass through. We can directly push the test tube 3 to be retrieved forward, causing the two corresponding rotating blocks 71 to rotate. The corresponding torsion spring 72 then deforms, allowing the test tube 3 to be removed. After the test tube 3 detaches from the corresponding rotating blocks 71, the two rotating blocks 71 will rotate in the opposite direction and reset under the reset action of the torsion spring 72. The test tube 3 containing exosomes can then be collected. Alternatively, the test tube 3 containing newly cultured secretions can be placed on the empty connecting ring 2. The smooth surface of the test tube 3 can be pressed forward against the two corresponding rotating blocks 71, causing the test tube 3 to push the two rotating blocks 71 to rotate. The corresponding torsion spring 72 then deforms. When the test tube 3 aligns with the two corresponding semi-circular grooves...The two corresponding rotating blocks 71 will rotate in the opposite direction and reset under the reset action of the corresponding torsion springs 72. In this way, the two semi-circular grooves form a circular groove, which clamps the test tube 3 to be stored. The test tube 3 is then fixed on the empty connecting ring 2. Then, people can press down on the corresponding connecting block 70, which drives the clamping mechanism 7 and the corresponding lifting rod 62 to move downward. This, in turn, drives the corresponding U-shaped rod 63, the corresponding connecting ring 2, and the test tube 3 to move downward. The corresponding U-shaped rod 63 can then push the tray 88 to move downward and reset. The downward movement of the tray 88 will drive the threaded rod 86 to rotate in the opposite direction. The threaded rod 86 will drive the one-way gear 87 to rotate. Since the rack 81 and the one-way gear 87 will disengage after reset, the rotation of the one-way gear 87 will not affect the gear. By using the method described in section 81, new exosomes can be stored inside the frame 1. The two cover plates 5 can then be replaced on the slots. The test tubes 3 inside the frame 1 can be removed one by one by rotating intermittently in a ring. Since the longer the exosomes are stored, the more easily their activity is lost, the motor 60's output shaft rotates 72 degrees to align one test tube 3 with the slot, allowing it to be removed via the lifting mechanism 8. The removal can be done sequentially according to storage time, with longer-stored test tubes being removed more quickly. This avoids test tubes 3 remaining inside the frame 1 for extended periods without being removed. Precise removal based on storage time is not required; a time range can be set for greater convenience. After all the test tubes 3 containing exosomes have been removed, the cooler 4 can be turned off. Example 2

[0034] Based on Example 1, Figure 1 , Figure 2 , Figure 9 and Figure 10 As shown, it also includes a reset mechanism 9, which includes a fixed block 90, a connecting shaft 91, a slider 92, a connecting spring 93, and a reset spring 94. Fixed blocks 90 are symmetrically welded to the left and right sides of the top front side of the frame 1. Sliders 92 are slidably provided on the inner side of each of the two fixed blocks 90. A connecting spring 93 is connected between each of the two sliders 92 and the fixed block 90 on the same side. A connecting shaft 91 is provided on the top rear side of each of the two cover plates 5. The two connecting shafts 91 are slidably connected to the sliders 92 on the same side. A reset spring 94 is connected between each of the two connecting shafts 91 and the sliders 92 on the same side.

[0035] When it is necessary to remove the corresponding test tube 3, the cover plate 5 can be pulled upwards, causing the connecting shaft 91 to move upwards, thus compressing the reset spring 94. Initially, the connecting spring 93 is in a stretched state. When the cover plate 5 moves upwards and is no longer stuck in the slot, the cover plate 5 can be released. At this time, the slider 92 will slide outwards along the fixed block 90 under the reset action of the connecting spring 93, thereby causing the connecting shaft 91 and the cover plate 5 to move outwards and open, so that the cover plate 5 no longer blocks the slot, and the test tube 3 containing exosomes can be removed from the frame 1. Thus, under the action of the reset mechanism 9, without The cover plate 5 needs to be removed directly to avoid having nowhere to put it after removal, and also to increase the stability of the cover plate 5 and prevent it from being easily removed. After the corresponding exosome is removed, people can pull the slider 92 inward, so that the slider 92 slides inward along the fixed block 90 and resets. The connecting spring 93 is stretched accordingly, and the slider 92 moves inward, which in turn drives the connecting shaft 91 and the cover plate 5 to slide inward. When the cover plate 5 moves to be aligned with the slot, the connecting shaft 91 will drive the cover plate 5 to move downward under the reset action of the reset spring 94, so that the cover plate 5 is locked into the slot, thus closing the cover plate 5.

[0036] exist Figure 2 and Figure 11 As shown, it also includes a buffer mechanism 10, which includes a buffer pad 100 and a buffer spring 101. The bottom of the frame 1 is slidably provided with a buffer pad 100 that can buffer the device. The buffer pad 100 is connected to the bottom of the frame 1 by a buffer spring 101.

[0037] When people place this device in the designated storage room, the cushioning pad 100 at the bottom of the frame 1 will first contact the table, followed by the frame 1 contacting the table. At this time, the cushioning spring 101 will be compressed due to the overall weight of the device, thus preventing the frame 1 from vibrating due to direct contact with the table. The cushioning spring 101 can cushion the frame 1, preventing the test tube 3 inside the frame 1 from breaking and increasing safety. When people pick up this device from the table, the frame 1 and the cushioning pad 100 will separate from the table one by one, and the cushioning pad 100 will move downwards and reset under the reset action of the cushioning spring 101.

[0038] exist Figure 1 and Figure 12 As shown, it also includes a placement mechanism 11, which includes a placement rack 110 and silicone blocks 111. The placement rack 110 is provided on the top rear side of the frame 1. Five silicone blocks 111 that can temporarily store test tubes 3 are evenly arranged on the placement rack 110. Test tubes 3 can be placed on silicone blocks 111.

[0039] When people remove the test tube 3 containing the secretion from the frame 1, it can be temporarily placed on the silicone block 111. Due to its material, the silicone block 111 will rub against the test tube 3, which can fix the test tube 3. After people close the cover 5, the test tube 3 can be taken out of the silicone block 111 for use. In this way, the silicone block 111 can temporarily store some test tubes 3. Whether it is necessary to store the secretion inside the frame 1 or to take out the secretion, it can be temporarily placed on the silicone block 111 to avoid having nowhere to put the test tube 3 in hand.

[0040] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention.

Claims

1. A storage device for mesenchymal stem cell exosomes, comprising a frame (1), connecting rings (2), a cooler (4), and cover plates (5), wherein an annular groove is formed at the bottom of the frame (1), five connecting rings (2) are evenly placed on the annular groove, the cooler (4) is installed in the middle of the bottom of the frame (1), and a slot is formed at the front of the top of the frame (1), on which two cover plates (5) are engaged, the two cover plates (5) being in contact with each other, characterized in that: It also includes a rotating mechanism (6), a clamping mechanism (7) and a lifting mechanism (8). The rotating mechanism (6) is located in the middle of the frame (1), and the clamping mechanism (7) is located on the rotating mechanism (6). The clamping mechanism (7) can limit the test tube (3). The lifting mechanism (8) is located at the bottom of the frame (1).

2. The storage device for mesenchymal stem cell exosomes as described in claim 1, characterized in that: The rotating mechanism (6) includes a motor (60), a rotating frame (61), a lifting rod (62) and a U-shaped rod (63). The motor (60) is located in the middle of the upper part of the frame (1). The rotating frame (61) is connected to the output shaft of the motor (60). Five lifting rods (62) are evenly slidably arranged in a circular pattern on the rotating frame (61). Each lifting rod (62) has a U-shaped rod (63) at its bottom. Each U-shaped rod (63) is connected to the connecting ring (2) on the same side.

3. The storage device for mesenchymal stem cell exosomes as described in claim 2, characterized in that: The clamping mechanism (7) includes a connecting block (70), a rotating block (71) and a torsion spring (72). Each lifting rod (62) has a connecting block (70) at the top. Each connecting block (70) has two rotating blocks (71) rotatably mounted on it. Each rotating block (71) is connected to the lower part of the connecting block (70) on the same side with a torsion spring (72). Each rotating block (71) has a semi-circular groove. The semi-circular grooves between each pair of corresponding rotating blocks (71) form a circular groove. The circular grooves between each pair of corresponding rotating blocks (71) are in contact with the test tube (3) on the same side. The outer wall of the rotating block (71) is a smooth surface.

4. The storage device for mesenchymal stem cell exosomes as described in claim 3, characterized in that: The lifting mechanism (8) includes a guide rod (80), a rack (81), a ring spring (82), a fixed rod (83), a protrusion (84), a compression spring (85), a threaded rod (86), a one-way gear (87), and a tray (88). The guide rod (80) is located on the bottom left front side of the frame (1). The rack (81) is slidably mounted on the guide rod (80). The ring spring (82) connects the rack (81) and the guide rod (80). The fixed rod (83) is located on the right rear side of the rack (81). The fixed rod (83) and the rack (81) are both located inside the frame (1). The fixed rod (83) is slidably mounted on the rear side of the fixed rod (83). A compression spring (85) is connected between the block (84), the protrusion (84) and the fixed rod (83). The U-shaped rod (63) can contact the protrusion (84) by rotation. A threaded rod (86) is rotatably provided on the bottom front side of the frame (1). A one-way gear (87) is provided at the lower part of the threaded rod (86). A tray (88) is slidably connected to the lower part of the threaded rod (86) at the position above the one-way gear (87). The tray (88) contacts the U-shaped rod (63). The rack (81) can mesh with the one-way gear (87) by rotation. A guide rod is connected to the bottom front side of the frame (1). The guide rod and the tray (88) are slidably connected.

5. The storage device for mesenchymal stem cell exosomes as described in claim 4, characterized in that: It also includes a reset mechanism (9) that can limit the position of the cover plate (5). The reset mechanism (9) includes a fixed block (90), a connecting shaft (91), a slider (92), a connecting spring (93), and a reset spring (94). Fixed blocks (90) are symmetrically arranged on the left and right sides of the top front side of the frame (1). Sliders (92) are slidably arranged on the inner side of both fixed blocks (90). A connecting spring (93) is connected between the two sliders (92) and the fixed blocks (90) on the same side. A connecting shaft (91) is arranged on the top rear side of both cover plates (5). The two connecting shafts (91) are slidably connected to the sliders (92) on the same side. A reset spring (94) is connected between the two connecting shafts (91) and the sliders (92) on the same side.

6. The storage device for mesenchymal stem cell exosomes as described in claim 5, characterized in that: It also includes a buffer mechanism (10) that can prevent the test tube (3) from breaking. The buffer mechanism (10) includes a buffer pad (100) and a buffer spring (101). The bottom of the frame (1) is provided with a buffer pad (100) in a sliding manner. The buffer pad (100) is connected to the bottom of the frame (1) by a buffer spring (101).

7. The storage device for mesenchymal stem cell exosomes as described in claim 6, characterized in that: It also includes a placement mechanism (11) that can temporarily store test tubes (3) and thus free up hands. The placement mechanism (11) includes a placement rack (110) and silicone blocks (111). The frame (1) has a placement rack (110) on the top rear side. Five silicone blocks (111) are evenly placed on the placement rack (110). The silicone blocks (111) are used to temporarily store test tubes (3).

8. The storage device for mesenchymal stem cell exosomes as described in claim 1, characterized in that: The inner wall of each connecting ring (2) is coated with anti-slip adhesive.

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