Program cooling instrument

Abstract

The invention discloses a programmed cooling instrument which comprises a heat preservation cabinet body, a first refrigerator, an air supply device and a control unit, the heat preservation cabinet body comprises a containing cavity capable of keeping the internal temperature, and a porous plate at the bottom allows air circulation and bears multiple sets of basket assemblies at the same time; the air supply device conveys a cooling medium generated by the first refrigerator into the whole containing cavity and is used for cooling the whole basket assembly. A cooling medium is communicated with the circulating air duct through the through hole array of the bottom perforated plate and the through hole array of the top perforated plate, so that airflow circulation is realized; the flow guide device guides the cooling medium to ensure that the cooling medium is uniformly distributed in the accommodating chamber and is accurately guided to the sample. According to the programmed cooling instrument, the cooling medium is conveyed upwards from the lower portion of the heat preservation cabinet body, the cooling medium is guided to the standard plate frames and the samples through the flow guiding device, the uniform cooling effect can be provided for the whole basket assembly, and the samples are prevented from moving among the different plate frames.

Description

Technical Field

[0001] This invention relates to the field of isolator technology, and in particular to a programmed cooling device. Background Technology

[0002] Existing cooling equipment involves placing sample tubes into relatively loosely spaced custom-made racks for programmed cooling. The process requires placing each sample individually into the rack, then into a programmed cooling system. After cooling, each sample is removed from the system and transferred to a standard rack (133 square box rack, SBS rack, or other standard racks), before being placed into a low-temperature storage device. The standard racks are compact, with small gaps between samples, making them unsuitable for effective cooling by existing equipment.

[0003] The above process may lead to repeated freeze-thaw cycles on the samples, which may damage them. When performing large-scale (thousands or tens of thousands) programmed cooling of samples, the entire process is done manually, which is a huge workload and may require several people to transfer and freeze the samples at the same time. In addition, existing equipment has the problem of not being able to interface with automated equipment, and it is not possible to use a robotic arm to place the samples directly into the programmed cooling instrument for programmed cooling. There is also the problem of not being able to use a robot to transfer the programmed cooled samples to the low-temperature storage device.

[0004] Therefore, there is an urgent need to develop a programmed cooling device that can cool a standard plate frame as a whole to solve the above problems. Summary of the Invention

[0005] The purpose of this invention is to provide a programmed cooling device that solves the problem that programmed cooling devices cannot provide uniform and effective cooling.

[0006] To achieve the above-mentioned objective, the present invention provides a programmable cooling device, comprising an insulated cabinet, a first cooler, an air supply device, and a control unit;

[0007] The insulated cabinet is provided with a receiving chamber and a circulating air duct surrounding the receiving chamber. The top of the receiving chamber has an opening, and a top perforated plate is provided at the top opening of the receiving chamber. A bottom perforated plate is provided at the bottom of the receiving chamber. The internal space of the receiving chamber is connected to the circulating air duct through the through-hole array of the bottom perforated plate and the through-hole array of the top perforated plate.

[0008] The upper surface of the bottom perforated plate is provided with multiple sets of basket seats for supporting the basket assembly. The first cooler and the air supply device are both located in the heat preservation cabinet and below the bottom perforated plate. The air outlet of the air supply device faces the receiving chamber. The cooling medium generated by the first cooler passes through the bottom perforated plate under the action of the air supply device and is transported to the receiving chamber. Then it passes through the top perforated plate and flows into the circulating air duct.

[0009] The receiving chamber is equipped with a flow guiding device, which guides the flow of the cooling medium.

[0010] Both the first cooler and the air supply device are connected to the control unit, which controls the operating status of the first cooler and the air supply device according to the cooling requirements of the biological sample.

[0011] Optionally, the circulating air duct includes a first side wall air duct, a top air duct, and a second side wall air duct connected in sequence; the top air duct is disposed at the top of the receiving chamber, the first side wall air duct and the second side wall air duct are respectively disposed on opposite sides of the receiving chamber, and the tops of the first side wall air duct and the second side wall air duct are connected to the top air duct, and the bottoms of the first side wall air duct and the second side wall air duct are connected to the space below the bottom perforated plate.

[0012] Optionally, the top perforated plate includes a rectangular plate and a rectangular frame disposed on the rectangular plate. The array of through holes of the top perforated plate is formed on the rectangular plate. The rectangular plate also has a first ventilation connection port and a second ventilation connection port. The first ventilation connection port and the second ventilation connection port are symmetrically disposed on opposite sides of the array of through holes, and are used to connect the first side wall air duct and the second side wall air duct respectively.

[0013] Optionally, it also includes a heat-insulating cover, which is rotatably mounted on the heat-insulating cabinet body. The side of the heat-insulating cover facing the receiving chamber is the inner wall. The rectangular frame of the top perforated plate is fixedly connected to the inner wall of the heat-insulating cover, and the top air duct is formed between the rectangular plate of the top perforated plate and the inner wall of the heat-insulating cover.

[0014] Optionally, a side wall ventilation opening is provided on the side wall of the rectangular frame, and a pressure relief port is provided on the side wall of the insulated cabinet. The pressure relief port and the side wall ventilation opening are opposite to each other and are connected to each other to connect the external environment and the top air duct.

[0015] Optionally, the top of the first sidewall air duct and the second sidewall air duct are respectively provided with a third ventilation connection port and a fourth ventilation connection port, the third ventilation connection port and the fourth ventilation connection port corresponding to the first ventilation connection port and the second ventilation connection port respectively.

[0016] Optionally, the heat preservation cabinet is provided with a first side wall ventilation plate and a second side wall ventilation plate. The first side wall ventilation plate forms a first side wall air duct with the first side wall of the heat preservation cabinet, and the second side wall ventilation plate forms a second side wall air duct with the second side wall of the heat preservation cabinet. Both the first side wall ventilation plate and the second side wall ventilation plate are L-shaped plates. The third ventilation connection port or the fourth ventilation connection port is opened on the horizontal section of the L-shaped plate, and the end of the vertical section of the L-shaped plate that is not connected to the horizontal section is connected to the bottom perforated plate.

[0017] Optionally, the flow guiding device includes a plurality of side wall flow guiding plates symmetrically arranged on the first side wall ventilation plate and the second side wall ventilation plate. Each side wall flow guiding plate includes a side wall fixing plate and a first flow guiding plate. The side wall flow guiding plate is fixed to the first side wall ventilation plate or the second side wall ventilation plate by the side wall fixing plate. A first included angle is formed between the first flow guiding plate and the first side wall ventilation plate or between the first flow guiding plate and the second side wall ventilation plate.

[0018] Optionally, the flow guiding device further includes intermediate flow guiding plates arranged sequentially along the height direction, wherein the intermediate flow guiding plates are located between two adjacent sets of basket seats in the horizontal direction.

[0019] Optionally, the intermediate guide plate includes a second guide plate, an intermediate ventilation plate, and a third guide plate connected in sequence; the second guide plate and the third guide plate form a second angle and a third angle with the intermediate ventilation plate, respectively; the intermediate ventilation plate is parallel to the bottom perforated plate and is uniformly provided with a plurality of ventilation holes.

[0020] Optionally, the control unit includes a first solenoid valve connected to the first cooler and an air supply control device connected to the air supply device.

[0021] Optionally, the insulated cabinet also includes a second cooler, one end of which is fixed to the bottom perforated plate, and the other end of which surrounds the basket base and extends upward in a vertical direction.

[0022] Optionally, the control unit includes a second solenoid valve connected to the second cooler.

[0023] Optionally, the basket support is used to support a basket assembly with multiple standard plate frames arranged thereon. The standard plate frames include SUS plate frames or 133 square box plates, and the spacing between the sample tubes arranged on the SUS plate frames and the 133 square box plates is less than 2mm.

[0024] Compared with the prior art, the cooling medium delivery process in the programmed cooling instrument provided by this invention starts from the bottom of the receiving chamber. The air supply device delivers the cooling medium generated by the first cooler to the entire receiving chamber for cooling the entire basket assembly. The cooling medium is connected to the circulating air duct through the through-hole array of the bottom perforated plate and the through-hole array of the top perforated plate to achieve airflow circulation. The flow guiding device guides the cooling medium to ensure that the cooling medium is evenly distributed in the receiving chamber and accurately guided to the sample, thereby achieving uniform cooling of the sample in the basket assembly, improving cooling efficiency, and ensuring the consistency of cooling effect. The upper surface of the bottom perforated plate is provided with multiple sets of basket seats for supporting the basket assembly and positioning the basket assembly. The basket assembly directly performs programmed cooling of the sample, which can be automated. A robotic arm or robot can directly lift the basket assembly into the programmed cooling instrument for programmed cooling. After completion, it can be directly lifted and transferred to the low-temperature storage device, avoiding repeated transfer of the sample rack. Attached Figure Description

[0025] Figure 1 This is a cross-sectional view of the programmed cooling device in an embodiment of the present invention;

[0026] Figure 2 This is a schematic diagram of the programmed cooling device in an embodiment of the present invention. Figure 1 ;

[0027] Figure 3 This is a schematic diagram of the programmed cooling device in an embodiment of the present invention. Figure 2 ;

[0028] Figure 4 This is a schematic diagram of the programmed cooling device in an embodiment of the present invention. Figure 3 ;

[0029] Figure 5 This is a schematic diagram of airflow direction in an embodiment of the present invention;

[0030] Figure 6 This is a schematic diagram of the top air duct structure in an embodiment of the present invention;

[0031] Figure 7 This is a schematic diagram of the top perforated plate structure in an embodiment of the present invention;

[0032] Figure 8 This is a schematic diagram of the second sidewall ventilation panel structure in an embodiment of the present invention;

[0033] Figure 9 This is a schematic diagram of the sidewall guide plate structure in an embodiment of the present invention;

[0034] Figure 10 This is a schematic diagram of the intermediate guide plate structure in an embodiment of the present invention;

[0035] Figure 11This is a schematic diagram of the first refrigerator structure in an embodiment of the present invention;

[0036] Figure 12 This is a schematic diagram of the second refrigerator structure in an embodiment of the present invention;

[0037] Figure 13 This is a schematic diagram of the programmed cooling device in an embodiment of the present invention. Figure 4 .

[0038] In the diagram, 1. Insulation cover; 2. Insulation cabinet body; 3. Base; 4. Back cover; 5. Motor; 6. First side wall air duct; 7. Second side wall air duct; 71. Fourth ventilation connection port; 72. Second side wall ventilation plate; 8. Top air duct; 81. Rectangular plate; 82. Top air inlet; 83. Second ventilation connection port; 9. Middle guide plate; 91. Second guide plate; 92. Middle ventilation plate; 93. Third guide plate; 10. Side wall guide plate; 101. Side wall solid... 102. Fixed plate; 113. First guide plate; 114. First synchronous pulley; 115. Second synchronous pulley; 116. Synchronous belt; 12. Drive shaft; 13. Air supply device; 14. First cooler; 151. Cooling hole; 16. Second cooler; 17. First solenoid valve; 18. Second solenoid valve; 19. Fixed bracket; 20. Bottom perforated plate; 21. Side wall vent; 22. Basket seat; 23. Basket assembly; 25. Pressure relief port; 26. Standard plate frame. Detailed Implementation

[0039] The present invention will now be described in more detail with reference to the accompanying drawings, which illustrate preferred embodiments of the invention. It should be understood that those skilled in the art can modify the invention described herein while still achieving its advantageous effects. Therefore, the following description should be understood as being of general knowledge to those skilled in the art and is not intended to limit the invention.

[0040] The invention is described more specifically by way of example in the following paragraphs with reference to the accompanying drawings. The advantages and features of the invention will become clearer from the following description. It should be noted that the drawings are in a very simplified form and use non-precise proportions, and are only used to facilitate and clarify the illustration of the embodiments of the invention.

[0041] This invention provides a programmed cooling device; please refer to [the documentation / reference]. Figure 1 - Figure 4The system includes an insulated cabinet 2, a first cooler 15, an air supply device 14, and a control unit. The insulated cabinet 2 has a receiving chamber and a circulating air duct surrounding the receiving chamber. The receiving chamber has an opening at the top, and a top perforated plate is provided at the top opening of the receiving chamber. The receiving chamber has a bottom perforated plate 20 at the bottom. The internal space of the receiving chamber is connected to the circulating air duct through the through-hole array of the bottom perforated plate 20 and the through-hole array of the top perforated plate. The upper surface of the bottom perforated plate 20 has multiple sets of basket seats 22 for supporting the basket assembly 23. The first cooler 15 and the air supply device 14 are both located in the insulated cabinet 2 and below the bottom perforated plate 20. The air outlet of the air supply device 14 faces the receiving chamber. The cooling medium generated by the first cooler 15 passes through the bottom perforated plate 20 under the action of the air supply device 14 and is transported to the receiving chamber. Then it passes through the top perforated plate and flows into the circulating air duct.

[0042] The containment chamber is equipped with a flow guiding device, which guides the flow of the cooling medium; the first cooler 15 and the air supply device 14 are both connected to the control unit, which controls the working status of the first cooler 15 and the air supply device 14 according to the cooling requirements of the biological sample.

[0043] In this embodiment, the insulated cabinet 2 includes a receiving chamber that can maintain the internal temperature and an opening that allows biological samples to enter and exit. The control unit is connected to the first cooler 15 and the air supply device 14, providing power or energy to control the first cooler 15 and the air supply device 14. The cooling medium is delivered from bottom to top in the insulated cabinet 2 through the first cooler 15 and the air supply device 14, and guided by the flow guiding device to each shelf of the basket assembly 23, and evenly distributed among the basket assemblies 23, precisely guiding the biological samples placed on each shelf; the bottom perforated plate 20 and the top perforated plate allow air to pass through. Airflow is achieved through the perforated array of the bottom perforated plate 20 and the top perforated plate, allowing the cooling medium to flow into the circulation duct and achieve internal airflow circulation. The upper surface of the bottom perforated plate 20 is provided with multiple sets of basket seats 22 for supporting the basket assembly 23, which are used to position the basket assembly 23 and directly perform sample programmed cooling on the entire basket assembly 23. A robotic arm or robot can directly lift the basket assembly 23 into the programmed cooling device for programmed cooling. After completion, it can be directly lifted and transferred to the low-temperature storage device, avoiding repeated transfer of samples to the rack. The programmed cooling device provided in this embodiment can provide a uniform cooling effect on the entire basket assembly 23.

[0044] Preferably, the material of the insulated cabinet 2 is polyurethane foam with low thermal conductivity, which makes it possible to achieve a long-term low-temperature environment inside the containment chamber.

[0045] Preferably, the air supply device 14 includes a fan.

[0046] Furthermore, it also includes a fixing bracket 19, one end of which is fixedly installed at the bottom of the heat preservation cabinet 2, and the other end is connected to the bottom perforated plate 20. The fixing bracket 19 is used to support the bottom perforated plate 20.

[0047] Furthermore, the circulating air duct includes a first side wall air duct 6, a top air duct 8, and a second side wall air duct 7 connected in sequence; the top air duct 8 is disposed at the top of the receiving chamber, the first side wall air duct 6 and the second side wall air duct 7 are respectively disposed on opposite sides of the receiving chamber, and the tops of the first side wall air duct 6 and the second side wall air duct 7 are both connected to the top air duct 8, and the bottoms connect to the space between the bottom perforated plate 20 and the bottom of the heat preservation cabinet 2.

[0048] In this embodiment, the circulating air duct forms an internal airflow circulation system. The first side wall air duct 6 and the second side wall air duct 7 are located on opposite sides of the receiving chamber, and the tops of the first side wall air duct 6 and the second side wall air duct 7 are connected to the top air duct 8, respectively. The bottoms of the first side wall air duct 6 and the second side wall air duct 7 are connected to the space between the bottom of the bottom perforated plate 20 and the bottom of the heat preservation cabinet 2, thereby forming an airflow circulation system surrounding the receiving chamber.

[0049] Please refer to Figure 5 It should be noted that Figure 5 The arrows indicate the direction of airflow. The circulating air duct provides direction for the airflow within the receiving chamber. After heat exchange, the air enters the top air duct 8 and is guided downwards through the first side wall air duct 6 and the second side wall air duct 7. After entering the top air duct 8 from the upper part of the receiving chamber, the air flows back to the lower part of the receiving chamber through the first side wall air duct 6 and the second side wall air duct 7, forming a closed-loop airflow circulation to ensure uniform cooling of the sample in the basket assembly 23. Recycling the cooling medium reduces energy consumption and improves the energy efficiency ratio of the equipment. In addition, the circulating air duct helps improve heat exchange efficiency because the continuous airflow within the duct can continuously remove heat from the basket assembly 23. The circulating air duct also provides the possibility of precise control over the direction and speed of airflow.

[0050] For details, please refer to Figure 6 - Figure 7The top perforated plate includes a rectangular plate 81 and a rectangular frame disposed on the rectangular plate 81. The array of through holes of the top perforated plate is formed on the rectangular plate 81. The rectangular plate 81 is also provided with a first ventilation connection port and a second ventilation connection port 83. The first ventilation connection port and the second ventilation connection port 83 are symmetrically arranged on opposite sides of the rectangular plate 81, and are used to connect the first side wall air duct 6 and the second side wall air duct 7 respectively.

[0051] In this embodiment, the array of through holes in the top perforated plate is the top air inlet 82, and the top air inlet 82 faces the air outlet of the air supply device 14.

[0052] It should be noted that the first ventilation connection port and the second ventilation connection port 83 are symmetrically arranged. Figure 6 Only the second ventilation connection port 83 is labeled, while the first ventilation connection port is not marked.

[0053] Furthermore, it also includes a heat-insulating cover 1, which matches the top opening of the receiving chamber. The heat-insulating cover 1 is rotatably mounted on the heat-insulating cabinet 2. The side of the heat-insulating cover 1 facing the receiving chamber is the inner wall. The rectangular frame of the top perforated plate is fixedly connected to the inner wall of the heat-insulating cover 1. The top air duct 8 is formed between the rectangular plate 81 of the top perforated plate and the inner wall of the heat-insulating cover 1.

[0054] It should be noted that, Figure 7 Only the top air inlet 82 on the rectangular plate 81 is shown; the first ventilation connection port and the second ventilation connection port 83, which are symmetrically arranged on opposite sides of the rectangular plate 81, are not shown.

[0055] Furthermore, a side wall ventilation opening 21 is provided on the side wall of the rectangular frame, and a pressure relief port 25 is provided on the side wall of the heat preservation cabinet 2. The pressure relief port 25 and the side wall ventilation opening 21 are opposite to each other and are connected to each other, so as to connect the external environment and the top air duct 8.

[0056] In this embodiment, please continue to refer to Figure 5 The heat preservation cabinet has a pressure relief vent 25 on its side wall and a side wall ventilation opening 21. Figure 5 Not shown in the diagram, the pressure relief port 25 and the side wall vent 21 connect to the external environment and the top air duct 8, balancing the internal and external pressures and preventing pressure differences caused by temperature changes or airflow. They may also be used to safely release any steam or other gases that may accumulate inside.

[0057] Furthermore, the top of the first side wall air duct 6 and the second side wall air duct 7 are respectively provided with a third ventilation connection port and a fourth ventilation connection port 71, which correspond to the first ventilation connection port and the second ventilation connection port 83 respectively.

[0058] Furthermore, the heat preservation cabinet 2 is provided with a first side wall ventilation plate and a second side wall ventilation plate 72, which together with the inner side wall of the heat preservation cabinet 2 form the first side wall air duct 6 and the second side wall air duct 7, respectively.

[0059] Specifically, the first side wall ventilation panel and the first side wall of the insulated cabinet 2 form the first side wall air duct 6, and the second side wall ventilation panel 72 and the second side wall of the insulated cabinet 2 form the second side wall air duct 7.

[0060] Please refer to Figure 8 Both the first side wall ventilation panel and the second side wall ventilation panel 72 are L-shaped panels. The third ventilation connection port or the fourth ventilation connection port 71 is provided on the horizontal section of the L-shaped panel. The end of the vertical section of the L-shaped panel that is not connected to the horizontal section is connected to the bottom perforated plate 20.

[0061] It should be noted that the first sidewall ventilation panel and the second sidewall ventilation panel 72 have the same structure. Figure 8 Take the second side wall ventilation plate 72 and the fourth ventilation connection port 71 opened on the second side wall ventilation plate 72 as an example.

[0062] In this embodiment, the first sidewall ventilation panel and the second sidewall ventilation panel 72 make the air duct system modular, which is convenient for maintenance and replacement.

[0063] For further details, please refer to... Figure 9 The flow guiding device includes a plurality of side wall flow guiding plates 10 symmetrically arranged on the first side wall ventilation plate and the second side wall ventilation plate 72. The plurality of side wall flow guiding plates 10 are arranged sequentially along the height direction. Each side wall flow guiding plate 10 includes a side wall fixing plate 101 and a first flow guiding plate 102. The side wall flow guiding plate 10 is fixed to the first side wall ventilation plate or the second side wall ventilation plate 72 by the side wall fixing plate 101. A first included angle is formed between the first flow guiding plate 102 and the first side wall ventilation plate or between the first flow guiding plate 102 and the second side wall ventilation plate 72.

[0064] For further details, please refer to... Figure 10 The flow guiding device also includes intermediate flow guiding plates 9 arranged sequentially along the height direction, and the intermediate flow guiding plates 9 are located between two adjacent sets of basket seats 22 in the horizontal direction.

[0065] Furthermore, the intermediate guide plate 9 includes a second guide plate 91, an intermediate ventilation plate 92, and a third guide plate 93 connected in sequence; the second guide plate 91 and the third guide plate 93 form a second angle and a third angle with the intermediate ventilation plate 92, respectively; the intermediate ventilation plate 92 is parallel to the bottom perforated plate 20 and is uniformly provided with a plurality of ventilation holes, preferably, the ventilation holes are waist-shaped holes; the two ends of the intermediate guide plate 9 are provided with connecting pieces, and the intermediate guide plate 9 is fixed to the side walls on the front and rear sides of the heat preservation cabinet 2 by the connecting pieces.

[0066] Please continue to refer to this. Figure 5 In this embodiment, the sidewall guide plate 10 and the middle guide plate 9 guide the airflow containing the cooling medium along the sidewall or between the basket assemblies 23 to form airflow channels, ensuring that the cooling medium can be evenly distributed in each layer of the basket assembly 23, thereby optimizing the airflow path. The cold air can more evenly cover all areas of the receiving chamber, and the modular design of the sidewall guide plate 10 and the middle guide plate 9 facilitates maintenance and replacement.

[0067] Furthermore, the ventilation holes provided on the intermediate ventilation plate 92 allow airflow to pass through. The design of the first, second, and third included angles can be optimized according to the principles of airflow dynamics and the height of each sample layer to achieve the best airflow distribution and heat exchange effect.

[0068] Preferably, the second included angle and the third included angle are obtuse angles.

[0069] Furthermore, the control unit includes a first solenoid valve 17 connected to the first cooler 15 and an air supply transmission device connected to the air supply device 14.

[0070] Please continue to refer to this. Figure 3 The air supply transmission device includes a motor 5, a first synchronous pulley 111, a second synchronous pulley 112, a synchronous belt 12, and a transmission shaft 13. The output end of the motor 5 is connected to the first synchronous pulley 111, and the first synchronous pulley 111 and the second synchronous pulley 112 are driven by the synchronous belt 12. One end of the transmission shaft 13 is connected to the second synchronous pulley 112, and the other end of the transmission shaft 13 is connected to the air supply device 14, thereby driving the air supply device 14 to rotate.

[0071] For further information, please refer to the following: Figure 2 The insulated cabinet 2 also includes a second cooler 16, one end of which is fixed to the bottom perforated plate 20, and the other end of which surrounds the basket seat 22 and extends upward in the vertical direction.

[0072] Furthermore, the control unit includes a second solenoid valve 18 connected to the second cooler 16.

[0073] In this embodiment, preferably, please refer to Figure 11 - Figure 12 The first cooler 15 and the second cooler 16 include a refrigerant pipe, through which liquid nitrogen flows, and multiple cooling holes 151 are arranged on the inner wall of the refrigerant pipe. Liquid nitrogen is sprayed out from the cooling holes 151, and under the action of the air supply device 14, the liquid nitrogen is blown from the bottom to the top to cool the containing chamber and the sample.

[0074] The first cooler 15 and the second cooler 16 are each controlled by a separate solenoid valve, allowing for zoned regulation of the amount of cooling medium.

[0075] Preferably, the refrigerant pipe of the first cooler 15 surrounds the air supply device 14, and the refrigerant pipe of the second cooler 16 surrounds the plate frame carrying the sample and extends upward.

[0076] Furthermore, the basket support 22 is used to support the basket assembly 23 on which multiple standard plate frames 26 are arranged. The standard plate frame 26 includes an SUS plate frame or a 133 square box plate. The spacing between the sample tubes arranged on the SUS plate frame and the 133 square box plate is less than 2mm.

[0077] The programmed cooling system provided in this embodiment can support multiple basket assemblies 23 with multiple layers of standard plate racks 26 arranged closely together, with sample tube spacing all below 2mm. Conventional programmed cooling systems have poor cooling effects on standard plate racks 26, poor internal cooling material circulation, and cannot provide uniform cooling. The programmed cooling system provided in this embodiment makes it possible to cool the standard plate racks 26 as a whole. Cooling the standard plate racks 26 as a whole allows for the transfer of samples between racks. After the samples are loaded onto the standard plate racks 26, they are moved into the programmed cooling system as a whole. After cooling is completed, the whole system is directly transferred to a cryogenic storage device. The standard plate racks 26 are suitable for both programmed cooling systems and cryogenic storage devices, avoiding the movement of samples between different racks.

[0078] For further details, please refer to... Figure 13 The insulated cabinet body 2 also includes an insulated cover hinge, with the insulated cover 1 and the insulated cabinet body 2 fixed at both ends to realize the opening and closing of the insulated cover 1.

[0079] Please continue to refer to this. Figure 13The programmable cooling device also includes a base 3 and a rear cover 4, which are respectively connected to the insulation cabinet 2. The motor 5 is fixed inside the rear cover 4. The base 3 is located below the insulation cabinet 2, providing a bearing space for the first synchronous pulley 111, the second synchronous pulley 112, the synchronous belt 12, and the drive shaft 13. The first solenoid valve 17 and the second solenoid valve 18 are respectively connected to the first cooler 15 and the second cooler 16 through the rear cover 4 and the insulation cabinet 2.

[0080] In summary, the programmed cooling device provided by this invention delivers cooling medium from the lower to the upper part of the receiving chamber through a first cooler and an air supply device, and guides the cooling medium to the standard plate rack and samples through a flow guiding device, achieving a uniform cooling effect. The circulating air duct set around the receiving chamber provides a channel and direction for airflow circulation. At the same time, a basket assembly for supporting and arranging multiple layers of standard plate racks is provided. The programmed cooling device provided by this invention can perform programmed cooling on the entire standard plate rack. After cooling is completed, the standard plate rack is moved, avoiding the movement of samples between different plate racks.

[0081] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A programmed cooling device, characterized in that, Includes insulated cabinet, primary refrigeration unit, air supply device, and control unit; The insulated cabinet is provided with a receiving chamber and a circulating air duct surrounding the receiving chamber. The top of the receiving chamber has an opening, and a top perforated plate is provided at the top opening of the receiving chamber. A bottom perforated plate is provided at the bottom of the receiving chamber. The internal space of the receiving chamber is connected to the circulating air duct through the through-hole array of the bottom perforated plate and the through-hole array of the top perforated plate. The upper surface of the bottom perforated plate is provided with multiple sets of basket seats for supporting the basket assembly. The first cooler and the air supply device are both located in the heat preservation cabinet and below the bottom perforated plate. The air outlet of the air supply device faces the receiving chamber. The cooling medium generated by the first cooler passes through the bottom perforated plate under the action of the air supply device and is transported to the receiving chamber. Then it passes through the top perforated plate and flows into the circulating air duct. The receiving chamber is equipped with a flow guiding device, which guides the flow of the cooling medium. Both the first cooler and the air supply device are connected to the control unit, which controls the operating status of the first cooler and the air supply device according to the cooling requirements of the biological sample.

2. The programmed cooling device as described in claim 1, characterized in that, The circulating air duct includes a first side wall air duct, a top air duct, and a second side wall air duct connected in sequence; the top air duct is located at the top of the receiving chamber, the first side wall air duct and the second side wall air duct are respectively located on opposite sides of the receiving chamber, and the tops of the first side wall air duct and the second side wall air duct are connected to the top air duct, and the bottoms of the first side wall air duct and the second side wall air duct are connected to the space below the bottom perforated plate.

3. The programmed cooling device as described in claim 2, characterized in that, The top perforated plate includes a rectangular plate and a rectangular frame disposed on the rectangular plate. The array of through holes of the top perforated plate is formed on the rectangular plate. The rectangular plate also has a first ventilation connection port and a second ventilation connection port. The first ventilation connection port and the second ventilation connection port are symmetrically arranged on opposite sides of the array of through holes, and are used to connect the first side wall air duct and the second side wall air duct respectively.

4. The programmed cooling device as described in claim 3, characterized in that, It also includes a heat-insulating cover, which is rotatably mounted on the heat-insulating cabinet body. The side of the heat-insulating cover facing the receiving chamber is the inner wall. The rectangular frame of the top perforated plate is fixedly connected to the inner wall of the heat-insulating cover, and the top air duct is formed between the rectangular plate of the top perforated plate and the inner wall of the heat-insulating cover.

5. The programmed cooling device as described in claim 3, characterized in that, The rectangular frame has a side wall ventilation opening on its side wall, and the heat preservation cabinet has a pressure relief port on its side wall. The pressure relief port and the side wall ventilation opening are opposite to each other and are connected to each other, so as to connect the external environment and the top air duct.

6. The programmed cooling device as described in claim 3, characterized in that, The top of the first side wall air duct and the second side wall air duct are respectively provided with a third ventilation connection port and a fourth ventilation connection port, which correspond to the first ventilation connection port and the second ventilation connection port respectively.

7. The programmed cooling device as described in claim 6, characterized in that, The heat preservation cabinet is provided with a first side wall ventilation plate and a second side wall ventilation plate. The first side wall ventilation plate forms a first side wall air duct with the first side wall of the heat preservation cabinet, and the second side wall ventilation plate forms a second side wall air duct with the second side wall of the heat preservation cabinet. Both the first side wall ventilation plate and the second side wall ventilation plate are L-shaped plates. The third ventilation connection port or the fourth ventilation connection port is opened on the horizontal section of the L-shaped plate. The end of the vertical section of the L-shaped plate that is not connected to the horizontal section is connected to the bottom perforated plate.

8. The programmed cooling device as described in claim 7, characterized in that, The flow guiding device includes a plurality of side wall flow guiding plates symmetrically arranged on the first side wall ventilation plate and the second side wall ventilation plate. Each side wall flow guiding plate includes a side wall fixing plate and a first flow guiding plate. The side wall flow guiding plate is fixed to the first side wall ventilation plate or the second side wall ventilation plate by the side wall fixing plate. A first included angle is formed between the first flow guiding plate and the first side wall ventilation plate or between the first flow guiding plate and the second side wall ventilation plate.

9. The programmed cooling device as described in claim 8, characterized in that, The flow guiding device also includes intermediate flow guiding plates arranged sequentially along the height direction, and the intermediate flow guiding plates are located between two adjacent sets of basket seats in the horizontal direction.

10. The programmed cooling device as described in claim 9, characterized in that, The intermediate guide plate includes a second guide plate, an intermediate ventilation plate, and a third guide plate connected in sequence; the second guide plate and the third guide plate form a second angle and a third angle with the intermediate ventilation plate, respectively; the intermediate ventilation plate is parallel to the bottom perforated plate and is uniformly provided with a plurality of ventilation holes.

11. The programmed cooling device as described in claim 1, characterized in that, The control unit includes a first solenoid valve connected to the first cooler and an air supply control device connected to the air supply device.

12. The programmed cooling device as described in claim 1, characterized in that, The insulated cabinet also includes a second cooler, one end of which is fixed to the bottom perforated plate, and the other end of which surrounds the basket base and extends upward in a vertical direction.

13. The programmed cooling device as described in claim 12, characterized in that, The control unit includes a second solenoid valve connected to the second cooler.

14. The programmed cooling device as described in claim 1, characterized in that, The basket support is used to support the basket assembly with multiple standard plate frames arranged on it. The standard plate frames include SUS plate frames or 133 square box plates. The spacing between the sample tubes arranged on the SUS plate frames and the 133 square box plates is less than 2mm.

Images