Composition for regulating qi and blood and application thereof in preparation of product for regulating qi and blood

Abstract

The invention provides a composition for regulating qi and blood and application of the composition in preparation of a product for regulating qi and blood. The composition comprises the following substances: red ginseng, American ginseng, radix astragali, radix rehmanniae, rhizoma polygonati, radix puerariae, hemepeptide, isomaltooligosacharide, gamma aminobutyric acid (GABA), rhizoma zingiberis, donkey-hide gelatin, spina date seeds, cubilose powder, momordica grosvenori, ferrous lactate, vitamin C, folic acid, vitamin B12, Chinese wolfberry primary pulp and jujube concentrated juice. According to the composition disclosed by the invention, through a specific proportion and a preparation process, a plurality of herbal components in the composition have a mutual synergistic effect, mutual supplement and support through different mechanisms, and jointly promote the generation and circulation of qi and blood, so that the symptom of deficiency of qi and blood is improved, and finally the effect of supplementing qi and blood is achieved. In addition, the composition is simple in preparation method, easy to operate and relatively high in edible safety.

Description

Technical Field

[0001] This invention relates to the field of medicinal and edible homologous composition application technology, specifically to a composition for regulating qi and blood and its application in the preparation of qi and blood regulating products. Background Technology

[0002] Qi and blood are important concepts in Traditional Chinese Medicine (TCM). "Qi" represents the driving force of life activities, while "blood" is the material basis for maintaining life activities. The sufficiency of Qi and blood directly affects a person's health. Imbalances in Qi and blood can lead to a series of symptoms, including fatigue, pale complexion, dizziness, palpitations, insomnia, cold hands and feet, irregular menstruation, and loss of appetite. These symptoms not only affect the quality of daily life but may also trigger deeper health problems such as weakened immunity, nervous system weakness, cardiovascular problems, indigestion, and reproductive system disorders. Qi and blood are fundamental to maintaining human life activities. Qi drives life activities, while blood nourishes all tissues and organs. They complement each other, jointly ensuring the normal functioning of the body, including the transport of nutrients, the enhancement of immune function, and the stability of mental state. They even play an important role in delaying aging. Therefore, maintaining sufficient Qi and blood is not only key to disease prevention but also the foundation for maintaining overall health and vitality.

[0003] In recent years, modern medical research, through interdisciplinary techniques such as molecular biology and biophysics, has revealed the relationship between Qi and blood and various physiological processes in the human body. Studies have shown that certain traditional Chinese medicine ingredients, such as ginseng and astragalus, have antioxidant, anti-inflammatory, and immunomodulatory effects, and can improve Qi and blood status at the molecular level. Clinical trials have also confirmed the effectiveness of these ingredients. For example, a randomized controlled trial involving 100 patients with Qi and blood deficiency showed that after taking a Chinese medicine combination containing astragalus and angelica, the patients' complexion improved in 80% of cases, and fatigue was reduced in 75% of cases.

[0004] Currently, the research and development of qi and blood replenishing products faces numerous technical challenges. First, ensuring the product's effectiveness and scientific basis is crucial. Although traditional Chinese medicine theories are widely used in folk medicine, more scientific research is needed to verify their efficacy, especially within the context of modern science. Second, due to the complexity of Chinese herbal ingredients, ensuring the consistency and stability of product quality is also a challenge. Furthermore, some Chinese herbal ingredients may have certain side effects, making ensuring product safety particularly important. Therefore, developing a safe, effective, easily absorbed composition with a unique formula will be an important direction for the development of qi and blood replenishing products. Improving product purity and absorption rate through modern production and quality control technologies, and ensuring product safety and effectiveness, will have significant clinical and social value. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a qi and blood regulating composition and its application in the preparation of qi and blood regulating products.

[0006] This invention provides a compound composition for regulating qi and blood, which includes, but is not limited to, the following ingredients and their weight ratios: red ginseng 300-350, American ginseng 20-25, astragalus 500-520, rehmannia 50-60, polygonatum 800-1000, dried ginger 8-15, donkey-hide gelatin 50-80, jujube seed 10-15, wolfberry juice 300-400, and jujube concentrated juice 8000-10000.

[0007] Furthermore, the Qi-tonifying and blood-nourishing compound composition also includes other raw materials, which include the following components by weight: 10-20g of kudzu root, 450-500g of blood peptides, 10-20g of bird's nest powder, 20-30g of monk fruit, and 6-10g of ferrous lactate, wherein the parts are all based on the dry weight of the raw materials.

[0008] The Qi and Blood Regulating Composition provided by this invention includes medicinal and edible raw materials, ordinary food raw materials and other food raw materials, and the effective ingredients, such as Astragalus membranaceus, American ginseng, Polygonatum sibiricum, red ginseng, Rehmannia glutinosa and other medicinal and edible raw materials, have a very high proportion and purity.

[0009] This invention provides a preparation process for a composition for regulating Qi and blood, comprising the following steps: Raw material preparation: Weigh the above-mentioned components according to specific weights: Weigh the following powdered raw materials: 300-350g of red ginseng, 20-25g of American ginseng, 500-520g of astragalus, 50-60g of rehmannia, 800-1000g of polygonatum, 8-15g of dried ginger, 50-80g of donkey-hide gelatin, 10-15g of jujube seed, 10-20g of kudzu root, 450-500g of blood peptide, 10-20g of bird's nest powder, and 20-30g of monk fruit for later use. Weigh the following liquid raw materials: 300-400g of wolfberry puree, 8000-10000g of jujube concentrated juice, and an appropriate amount of drinking water.

[0010] Mix evenly: Place the weighed powder raw materials into a high-speed homogenizer and mix evenly. Add the liquid raw materials and an appropriate amount of drinking water, and mix and homogenize for 20-35 minutes.

[0011] Filtration: Filter the homogenized liquid through a 300-400 mesh sieve.

[0012] Sterilization and bottling: The filtered liquid is sterilized at 100℃~120℃, then bottled and sealed for storage.

[0013] Preferably, the high-speed homogenizer in step (2) has a rotation speed of 25~30 Hz and a homogenization time of 20 min~30 min.

[0014] Preferably, in step (4), the high-pressure sterilization temperature is 105℃~110℃, the sterilization time is 20min~35min, and the cooling endpoint temperature is 30℃~35℃.

[0015] The qi-regulating blood composition and its preparation method provided by this invention have the following beneficial effects and advantages: Comprehensive regulation: Through the synergistic effect of various herbal ingredients, it comprehensively regulates Qi and blood, and improves the symptoms of Qi and blood deficiency.

[0016] Boost immunity: Ingredients such as American ginseng and astragalus can enhance immunity and improve the body's resistance.

[0017] Improve sleep: Ingredients such as jujube seed and dried ginger can help improve sleep quality.

[0018] Beauty and skin care: Ingredients such as bird's nest powder and wolfberry juice have beauty and skin care effects.

[0019] High safety: Made with natural herbal ingredients, it is harmless to the human body and suitable for long-term use. Figure 1 A simplified process flow for preparing the Qi-tonifying and blood-nourishing composition product provided by the present invention. Detailed Implementation

[0020] The following embodiments are provided to better understand the present invention and include, but are not limited to, the present invention. Unless otherwise specified, the experimental methods in the following embodiments are conventional methods. Unless otherwise specified, the experimental materials used in the following embodiments were purchased from conventional suppliers. The quantitative experiments in the following embodiments were all performed in triplicate, and the results were averaged. Example

[0021] A composition for regulating Qi and blood, consisting of the following ingredients in the indicated weight proportions: red ginseng: 1000 parts, American ginseng: 500 parts, astragalus: 750 parts, rehmannia: 500 parts, polygonatum: 1000 parts, blood peptide: 500 parts, donkey-hide gelatin: 60 parts, jujube seed: 20 parts, bird's nest powder: 15 parts, ferrous lactate: 10 parts, wolfberry puree: 4000 parts, and jujube concentrated juice: 3000 parts.

[0022] The preparation method includes the following steps: (1) Mix the above composition according to the corresponding weight to obtain a mixture; (2) Add an appropriate amount of drinking water to the mixed powder and stir and dissolve it thoroughly; (3) Filter the obtained homogeneous liquid; (4) Sterilize the filtered solution at 105°C for 30 minutes, and fill the cooled liquid into a glass bottle and seal it for storage. Example

[0023] A composition for regulating Qi and blood, consisting of the following ingredients in the indicated weight proportions: red ginseng: 100 parts, American ginseng: 20 parts, astragalus: 750 parts, rehmannia: 450 parts, polygonatum: 1200 parts, blood peptide: 450 parts, donkey-hide gelatin: 30 parts, jujube seed: 10 parts, bird's nest powder: 8 parts, ferrous lactate: 6 parts, wolfberry puree: 4000 parts, and jujube concentrated juice: 6000 parts.

[0024] The preparation method is the same as in Example 1. Example

[0025] A composition for regulating Qi and blood, consisting of the following ingredients in the indicated weight proportions: red ginseng: 300 parts, American ginseng: 50 parts, astragalus: 500 parts, rehmannia: 400 parts, polygonatum: 800 parts, blood peptide: 450 parts, donkey-hide gelatin: 50 parts, jujube seed: 15 parts, bird's nest powder: 10 parts, ferrous lactate: 1 part, wolfberry puree: 2000 parts, and jujube concentrated juice: 3500 parts.

[0026] The preparation method is the same as in Example 1. Example

[0027] A composition for regulating Qi and blood, consisting of the following ingredients in the indicated weight proportions: red ginseng: 350 parts, American ginseng: 20 parts, astragalus: 400 parts, polygonatum: 1000 parts, blood peptides: 460 parts, donkey-hide gelatin: 50 parts, jujube seed: 10 parts, bird's nest powder: 10 parts, wolfberry puree: 3000 parts, and jujube concentrated juice: 4000 parts.

[0028] The preparation method is the same as in Example 1. Example

[0029] Astragalus: The *Shennong Bencao Jing* records that "Astragalus is effective for carbuncles, chronic sores, draining pus and relieving pain, leprosy, hemorrhoids, and fistulas. It also tonifies deficiency." It has the effects of invigorating qi and strengthening the exterior, promoting tissue regeneration and detoxification, and promoting diuresis and reducing swelling, making it suitable for symptoms caused by qi deficiency. Astragalus can enhance the body's immune function and has a positive effect against infection. It can strengthen the immune system, promote the production of white blood cells, thereby improving the body's ability to resist external pathogens. In addition, astragalus can promote liver function, helping the liver to better synthesize proteins, thus providing the body with the necessary energy source.

[0030] American ginseng: According to the *Compendium of Materia Medica Supplement*, "American ginseng is sweet and slightly bitter in taste, cool in nature, and enters the lung and stomach meridians. It primarily nourishes the lungs and reduces heat, generates body fluids, and relieves fatigue. It treats pulmonary tuberculosis, cough, hematemesis, epistaxis, hematuria, metrorrhagia, and leukorrhea." It has the effects of nourishing yin and clearing heat, generating body fluids and quenching thirst, and is suitable for conditions of both qi and yin deficiency, such as fatigue, weakness, dry mouth and tongue. Studies show that American ginseng contains various ginsenosides, such as ginsenosides Rg1 and Rb1, which can enhance the body's energy metabolism and improve immune function. Ginsenoside Rg1 can also stimulate the central nervous system, improving alertness and anti-fatigue ability, while Rb1 helps reduce stress response and improve sleep quality, thereby indirectly promoting energy recovery.

[0031] Polygonatum: The *Shennong Bencao Jing* records that "Polygonatum primarily replenishes the middle energizer and invigorates qi, calms the five internal organs, strengthens muscles, and replenishes essence." It can replenish the middle energizer and invigorate qi, moisten the lungs and relieve cough, and strengthen muscles and bones. Polygonatum contains various amino acids and polysaccharides, which can enhance the body's antioxidant capacity, promote cell repair, and indirectly increase energy levels.

[0032] Donkey-hide gelatin (Ejiao): According to the Compendium of Materia Medica, it "treats abdominal pain, hematemesis, epistaxis, metrorrhagia, and dysentery." Donkey-hide gelatin can replenish blood, stop bleeding, and moisten dryness. A review article in *Chinese Medicine* summarized the potential mechanisms by which donkey-hide gelatin improves anemia.

[0033] Red ginseng: According to the Compendium of Materia Medica, it "primarily nourishes the five internal organs, calms the spirit, stabilizes the soul, stops palpitations, eliminates evil influences, brightens the eyes, and improves intelligence." It can greatly replenish vital energy, restore pulse and prevent collapse, and improve intelligence and brain function. It is suitable for symptoms such as physical weakness, palpitations, and shortness of breath. Studies have shown that red ginseng can improve endurance and relieve fatigue.

[0034] Goji berries: The *Shennong Bencao Jing* (Shennong's Classic of Materia Medica) records that "Goji berries treat internal evil qi, relieve heat and aid digestion, replenish liver qi, strengthen tendons and bones, build muscle, and increase strength." They nourish the liver and kidneys, improve eyesight, and strengthen tendons and bones. Goji berries are rich in antioxidants, such as beta-carotene and vitamin E, which help protect the integrity of red blood cell membranes and improve red blood cell survival rates.

[0035] Red dates: The *Shennong Bencao Jing* (Shennong's Classic of Materia Medica) records that "Red dates treat evil qi in the heart and abdomen, soothe the middle jiao and nourish the spleen, assist the twelve meridians, regulate stomach qi, open the nine orifices, replenish qi and body fluids, treat deficiencies in the body, fright, heaviness in the limbs, and harmonize with all medicines." They can replenish qi and blood, and calm the mind. Red dates contain various vitamins and minerals, providing comprehensive nutritional support.

[0036] Bird's nest: According to the "Compendium of Materia Medica", bird's nest "nourishes the lungs, treats weakness and consumption, coughs up bloody phlegm, can improve appetite and replenish deficiencies". It can moisturize the lungs and stop coughs, nourish the skin and beautify the complexion, and is suitable for symptoms such as dry cough and dry skin.

[0037] The raw materials provided by this invention, when formulated in a specific ratio, can produce a variety of new substances that regulate qi and blood. These substances include, but are not limited to, polysaccharides, flavonoids, short peptide chains, amino acid derivatives, polyphenolic compounds, and antioxidant products. Through synergistic effects, these new substances can better regulate qi and blood, enhance immune function, and provide antioxidant and anti-fatigue benefits.

[0038] Therefore, these ingredients and nutritional supplements can work synergistically to replenish qi and blood and improve symptoms of qi and blood deficiency, mainly based on the following principles: combinations such as red ginseng, astragalus, and American ginseng enhance the body's qi and blood circulation by replenishing qi and nourishing blood, promoting blood circulation and metabolism; they also regulate the functions of organs such as the liver and kidneys to nourish the whole body; vitamin C and isomaltooligosaccharides help resist disease by enhancing the body's immunity; folic acid and vitamin B12 prevent anemia by promoting red blood cell production; rehmannia and polygonatum improve the internal environment by nourishing yin and moisturizing dryness; and dried ginger improves blood circulation by promoting blood circulation and removing blood stasis.

[0039] Example 6:

[0040] Sixty volunteers aged 28-60 years with symptoms such as anemia and chronic fatigue, and without any underlying medical conditions, were randomly divided into two groups: an experimental group (n=30) and a control group (n=30). Statistical analysis showed no significant differences in gender, age, or weight between the two groups (P<0.05), indicating comparability. The test results are as follows:

[0041] Test subjects Test volunteers: 60; age: 28-60 years old, the 60 test subjects all have symptoms of anemia, mental fatigue, etc. Test method The 60 testees were randomly divided into 2 groups, 30 people in the test group and 30 people in the control group, and the oral liquid was drunk in the morning and evening every day for one month. Test group Test group: take the compound composition oral liquid provided by the application, 1 bottle of 50 ml, for one month Control group: a well-known brand of refreshing oral liquid on the market Notes During the test period, all testees maintained their original living habits Test results Test group: 21 people fed back that after drinking the oral liquid, they felt that their heads became clear, their energy was vigorous, and they became energetic; 8 people felt that the fatigue was relieved after taking it. Control group: 12 people felt that after drinking, their heads became clear, their energy was vigorous, and they became energetic; 7 people felt that the fatigue was relieved; 11 people felt that there was no effect after drinking. The results in Table 1 show that the compound composition of the present invention has significant effects in replenishing qi and blood and relieving fatigue.

[0042] Experimental Example 2: The compound composition prepared in Example 4 and Comparative Example 1 (blank group) were administered orally to mice, with 10 mice in each group. After 30 minutes of gavage treatment, the effect of the compound composition on the anti-fatigue ability of mice was tested according to the "Evaluation Procedures and Testing Methods for Functional Foods" (x±s, n=10). The results are shown in Table 1 below: Table 2. Results of fatigue resistance tests for different groups Drug handling Group Dose Swimming time (s) Drinking water Blank group 0 317±2.69 The composition of the application Test group 50ml 587±12.3 ** Note: ** indicates p<0.01, meaning the difference is highly significant compared to the control group.

[0043] Table 2 shows that, compared with the blank group, the experimental group mice with the compound composition prepared in this invention had significantly increased swimming time under load, indicating that the compound composition of this invention can significantly improve the anti-fatigue ability of normal mice.

[0044] Experimental Example 3: For the 60 subjects in Experiment 1, polysomnography was used to assess sleep parameters in both the experimental and control groups, including total sleep duration, number of awakenings, duration of awakenings, and the ratio of awakening duration to total recorded sleep duration. The results are as follows: Table 3 Comparison of polysomnography between the control group and the experimental group Group Total sleep time (min) Awakening times (times) Awakening time (min) The ratio of awakening time to recording time (%) Control group (n=30) 302.33±27.58 8.46±1.04 82.31±21.74 21.40 Test group (n=30) 394.73±31.74 * 4.21±1.58 * 58.94±25.01 * 13.00 * Note: * P < 0.05 compared with the control group. Table 3 shows that, compared with the control group, the experimental group had increased total sleep time, decreased number of awakenings, decreased awakening time, and a lower ratio of awakening time to recording time. Furthermore, there were significant differences between the experimental and control groups in total sleep time, number of awakenings, awakening time, and the ratio of awakening time to recording time (P < 0.05). The experimental group showed significantly better improvement in sleep quality compared to the control group.

[0045] In summary, the Qi and blood replenishing composition of this invention shows good effects in a short period of time, significantly improving the user's Qi and blood status and enhancing their quality of life. The research results support the effectiveness and safety of this product, providing strong evidence for its further promotion.

[0046] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition for regulating qi and blood and use thereof in the preparation of a product for regulating qi and blood, characterized in that, The composition includes but is not limited to the following ingredients: red ginseng, American ginseng, astragalus, rehmannia, polygonatum, radix puerariae, blood peptide, dried ginger, donkey-hide gelatin, jujube seed, bird's nest powder, momordica grosvenori, ferrous lactate, Chinese wolfberry juice, red date concentrate.

2. The blood conditioning composition of claim 1, wherein, The composition includes food-grade raw materials, common food raw materials and other food raw materials.

3. The blood conditioning composition of claim 1 or 2, wherein, The weight ratio of the main prescription food-grade raw materials is as follows: red ginseng 300-350, American ginseng 20-25, astragalus 500-520, rehmannia 50-60, polygonatum 800-1000, dried ginger 8-15, donkey-hide gelatin 50-80, jujube seed 10-15, Chinese wolfberry juice 300-400, and red date concentrate 8000-10000, wherein the amount is based on the dry weight of the raw materials.

4. The blood conditioning composition of claim 1 or 2, wherein, The auxiliary prescription also includes the following raw materials: radix puerariae 10-20, blood peptide 450-500, bird's nest powder 10-20, momordica grosvenori 20-30, and ferrous lactate 6-10, wherein the amount is based on the dry weight of the raw materials.

5. The blood circulation adjusting composition according to claims 1 to 4, wherein The composition is used for preparing oral preparations, pills, capsules and tablets.

6. The blood conditioning composition of claim 1, wherein, The effective ingredients in the composition account for a very high proportion, such as food-grade raw materials like astragalus, American ginseng, polygonatum, red ginseng and rehmannia.

7. A method of preparing the blood tonifying composition as claimed in claim 1 or 2 or 3 and its use in the preparation of blood tonifying products, characterized in that, The steps include: Raw material preparation, mixing various food-grade raw materials and other auxiliary raw materials according to a specific ratio, setting the volume to a certain scale with drinking water, mixing and homogenizing, filtering, sterilizing and bottling.

8. The production method according to claim 7, wherein The product preparation steps also include the selection of raw materials and strict control of the process.

9. The preparation process according to claims 7-8, characterized in that, The mixing homogenizer speed is 25-30 HZ, the high-pressure sterilization temperature is 100-115℃, the sterilization time is 25-30 min, and the cooling end temperature is 30-40℃.

10. A composition for regulating qi and blood and use thereof in the preparation of a product for regulating qi and blood, characterized in that: The various herbal ingredients in the composition synergize with each other to regulate blood and qi, improve sleep and maintain beauty and youth, further enhance immunity, and have high safety, which can be used for a long time.

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