Traditional Chinese medicine composition for repelling mosquitoes and restoring consciousness and application

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and discloses a traditional Chinese medicine composition for repelling mosquitoes and restoring consciousness and application thereof.The composition is composed of pogostemon cablin, folium artemisiae argyi, radix aucklandiae, clove, hempleaf negundo chastetree leaves, rhizoma acori graminei, mint, honeysuckle, borneol and magnolia flower. According to the preparation method, a matrix dispersing and premixing technology is adopted, borneol and mint are adsorbed in advance through a plant fiber structure, the problem that components easy to co-melt are liquefied and agglomerated in the crushing process is effectively solved, the micro powder of 80-120 meshes is prepared in combination with a low-temperature superfine crushing technology, and the prepared micro powder is uniform in particle size and high in practicability. The product disclosed by the invention is natural and safe, mild in smell, long in lasting period and suitable for multi-scene protection in summer.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind and application thereof. BACKGROUND

[0002] The high temperature and high humidity environment in summer is easy to breed mosquitoes, and mosquito bites not only cause skin itching and swelling, but also may spread dengue fever, Japanese encephalitis and other insect-borne infectious diseases. At the same time, the hot weather often causes the human body to appear drowsiness, fatigue, lack of concentration and dull thinking, etc. "Summer" symptoms, which seriously affect work and study efficiency. Therefore, seeking a safe protection means that can solve the problem of mosquito invasion and mental fatigue at the same time has wide market demand.

[0003] At present, the mainstream of mosquito repellent products on the market is mostly based on chemical synthetic preparations such as DEET, mosquito repellent ester or pyrethroid compounds as the core ingredient. Although this kind of chemical product has strong killing or repellent effect, its pharmacological toxicity and potential allergenic risk limit its application in infants, pregnant women and people with allergic constitution. Long-term contact or inhalation of high concentration of chemical volatile substances is easy to stimulate the respiratory mucosa and nervous system of the human body, and frequent use of single chemical ingredient is easy to induce mosquito population to produce drug resistance, resulting in the decline of protection effect with time.

[0004] In contrast, the traditional Chinese medicine sachet using natural plant volatile oil for olfactory repellent is concerned due to its high safety. However, the existing traditional Chinese medicine sachet formula is mostly limited to single mosquito repellent function, and often simply piles up traditional aromatic dampness drugs such as mugwort leaf, atractylodes and white peony root, focusing on avoiding stench and preventing insects. These traditional formulas often ignore the urgent need of the human body for refreshing and refreshing in high temperature environment, and the smell of some medicinal materials is too strong and heavy, which may even make the user feel more drowsy after wearing, and cannot achieve the balance of clearing the head and repelling mosquitoes.

[0005] In addition, there are independent refreshing products on the market, such as inhalers or cooling oils containing high concentration of menthol, but such products have single function, and users need to carry mosquito repellent and refreshing products at the same time, which is inconvenient to use. In the existing technical scheme, there is rarely a report on the scientific compatibility of broad-spectrum mosquito repellent activity of honeysuckle leaf and traditional Chinese medicine for opening the orifices and refreshing the mind, and the preparation process of the compound powder containing eucalyptus, peppermint and other eutectic components is not optimized, resulting in problems such as caking, unstable volatilization or short duration of the product, which is difficult to meet the demand of modern life for efficient, safe and multifunctional protection products. SUMMARY

[0006] In order to achieve the above purpose, the present application is realized by the following technical scheme: In a first aspect, the present application provides a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, which adopts the following technical scheme: A traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind is prepared from raw materials comprising, by weight, 1-15 parts of pachouli, 1-15 parts of mugwort leaves, 1-10 parts of costus root, 1-10 parts of clove, 1-10 parts of vitex leaves, 1-10 parts of acorus gramineus, 1-10 parts of mint, 1-10 parts of honeysuckle, 1-5 parts of borneol and 1-5 parts of lily of the valley.

[0007] By adopting the technical scheme, the mosquito-repelling and refreshing dual effects are realized by the synergistic effect of the components. The pachouli ketone, eucalyptol and eugenol contained in the pachouli, mugwort leaves, costus root and clove have olfactory interference effect on common mosquitoes, thereby achieving a basic broad-spectrum repellent effect. The vitex leaves are introduced as a synergistic component, and the unique ene terpene volatile oil of the vitex leaves is compounded with the above components to improve the repellent capacity for aggressive mosquito species such as aedes. Meanwhile, the high volatility and sublimation characteristics of borneol and mint are used as carriers to promote the diffusion of the acorus gramineus, lily of the valley and other components for opening the orifices and refreshing the mind. The volatile gas flow generated in the sublimation process of borneol can carry volatile oil molecules with relatively large molecular weight to migrate outward, thereby expanding the effective range of the sachet and forming an environment with refreshing effect around the user.

[0008] Preferably, the total weight ratio of the pachouli, mugwort leaves, costus root, clove and vitex leaves to the acorus gramineus, mint, honeysuckle, borneol and lily of the valley is controlled to be between 3:1 and 1:1. By adopting the technical scheme, the proportion of the fragrance-retaining components (such as pachouli, mugwort leaves and costus root) rich in sesquiterpenes and the high-volatility components (such as mint and borneol) rich in monoterpenes in the formula is balanced. If the proportion of the former components is too high, the fragrance diffusion is poor and the effect is slow. If the proportion of the latter components is too high, the volatilization is too fast and the duration is short. The proportion is controlled to be between 3:1 and 1:1, the high-volatility components can drive the release of the fragrance-retaining components, and the fiber structure of the fragrance-retaining components can adsorb the high-volatility components to delay the release, thereby constructing a stable slow-release system.

[0009] Preferably, the raw materials are in the following weight proportions: 8-12 parts of pachouli, 8-12 parts of mugwort leaves, 5-8 parts of costus root, 5-8 parts of clove, 8-12 parts of vitex leaves, 5-8 parts of acorus gramineus, 5-8 parts of mint, 3-5 parts of honeysuckle, 1.5-2.5 parts of borneol and 1.5-2.5 parts of lily of the valley. By adopting the technical scheme, the amount proportion of each component is optimized, so that the mosquito-repelling effect and the odor comfort reach a good balance, the irritating odor caused by excessive use of clove and mugwort leaves is avoided, and the continuous effect of the refreshing components under long-term wearing is ensured.

[0010] Preferably, the Vitex leaf is the dried leaf of Vitex negundo, a plant of the Verbenaceae family; the borneol is synthetic borneol or natural dextrorotatory borneol. By adopting the above technical solution, the biological source and chemical properties of the raw materials are clarified, ensuring that the content of vitexin and volatile oil in the Vitex leaf meets the efficacy requirements, and that the optical rotation and purity of the borneol meet the safety standards for use.

[0011] Preferably, the traditional Chinese medicine composition is in powder form, with a powder fineness passing through an 80-120 mesh sieve. The powder is encapsulated in a polypropylene spunbond nonwoven bag to form a sachet, and each sachet contains 25-50g of powder. By adopting the above technical solution, the traditional Chinese medicine is pulverized to a particle size of 80-120 mesh (approximately 125-180 micrometers), increasing the specific surface area of ​​the medicinal materials, disrupting the cell wall structure, and reducing the mass transfer resistance of intracellular volatile oils diffusing outward. Combined with a polypropylene spunbond nonwoven fabric with suitable air permeability, a constant rate of release of the active ingredients is achieved while ensuring no powder leakage.

[0012] Secondly, the present invention provides a method for preparing the above-mentioned mosquito-repelling and brain-awakening traditional Chinese medicine composition, using the following technical solution: A method for preparing a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind includes the following steps: Step 1, Raw material pretreatment: Weigh the prescribed amounts of each raw material, remove impurities and dry them; Step 2, coarse grinding: Mix all ingredients except borneol and mint, and grind them into coarse powder; Step 3, Premixing: Take 10%-15% of the total weight of the coarse powder obtained in Step 2 as the base, add the prescribed amount of borneol and peppermint and mix to obtain the premix; Step 4, ultrafine grinding: Combine the remaining coarse powder from step 2 with the premix obtained in step 3, perform ultrafine grinding, and sieve to obtain mixed powder. Step 5, Packaging: Pack the mixed powder into breathable packaging materials.

[0013] By adopting the above technical solution, the process challenges in pulverizing traditional Chinese medicine compound formulas containing eutectic components are solved. Addressing the issue of eutectic phenomena (i.e., the melting point of the two solids decreases after mixing, resulting in a liquid or semi-liquid state) that easily occurs when borneol and peppermint are mixed, this invention designs a matrix dispersion premixing process. Utilizing the abundant cellulose pore structure in the coarse powder of plant raw materials such as patchouli and artemisia argyi as a dispersion matrix, borneol and peppermint are pre-adsorbed. During the premixing process, borneol and peppermint molecules are dispersed and fixed on the surface and pores of the plant fibers, increasing the solid dispersion surface area and preventing macroscopic liquefaction and aggregation of the eutectic mixture. When the premixed material subsequently enters the ultrafine pulverization system, the easily eutectic components are isolated by the solid carrier, avoiding material sticking to the walls and screen clogging caused by localized temperature increases during pulverization, ensuring the uniformity of pulverization fineness and the continuous stability of production.

[0014] Preferably, in step one, the drying is hot air circulating drying at a temperature of 43℃-47℃, until the moisture content of the raw material is ≤9.0%. By adopting the above technical solution, controlling the drying temperature below 47℃ prevents the loss of heat-sensitive volatile oils in raw materials such as patchouli and cloves; at the same time, controlling the moisture content below 9.0% ensures the material brittleness required for subsequent pulverization, improves pulverization efficiency, and prevents the finished product from becoming moldy during storage.

[0015] Preferably, in step three, the premixing time is 3-8 minutes, allowing borneol and peppermint to adsorb onto the matrix surface. By employing the above technical solution, the uniform dispersion of borneol and peppermint in the matrix is ​​ensured. Too short a mixing time will result in incomplete adsorption and a risk of clumping; too long a mixing time may cause the material to heat up, leading to volatilization losses. A mixing time of 3-8 minutes is a suitable process parameter for achieving sufficient solid-solid dispersion without the accumulation of heat effects.

[0016] Preferably, in step four, the temperature of the grinding chamber is controlled to be <45℃. The sieving is performed through an 80-120 mesh sieve. The 80-120 mesh fineness setting ensures the release rate of volatile oils while avoiding particle agglomeration and clogging of the nonwoven fabric pores caused by excessively fine particles (such as those larger than 200 mesh).

[0017] Preferably, in step five, the breathable packaging material is a polypropylene spunbond nonwoven bag with a basis weight of 30-45 g / m²; the weight of the medicinal powder in each sachet is 25-50 g. The selected polypropylene spunbond nonwoven fabric has hydrophobic and breathable properties, and the basis weight of 30-45 g / m² provides a suitable micropore size, which can both prevent dust leakage and allow volatile molecules to pass freely.

[0018] Thirdly, the present invention provides an application of the above-mentioned traditional Chinese medicine composition in the preparation of a product that has both mosquito-repelling and brain-awakening effects.

[0019] By adopting the technical solution of the present invention, the traditional Chinese medicine composition is applied to the preparation of related products, which can effectively cope with the high temperature and humidity in summer and the breeding environment of mosquitoes, meet the dual needs of users for insect bite prevention and refreshing the mind, and is especially suitable for specific groups such as students, drivers and outdoor workers.

[0020] This invention provides a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, and its application. It possesses the following beneficial effects: (1) This invention achieves the dual effects of mosquito repellency and mental alertness through scientific formulation. Vitex negundo leaves are introduced into the formula as an synergistic component, and their volatile oil components enhance the repellency effect against aggressive mosquitoes such as Aedes mosquitoes, making up for the shortcomings of traditional Artemisia argyi formulas; at the same time, the sublimation and high volatility of borneol and peppermint are used as carriers to promote the diffusion of the mind-opening and refreshing components such as Acorus tatarinowii, thus providing users with an effective protective and refreshing environment without adding chemical mosquito repellents.

[0021] (2) The preparation process of this invention solves the problem of agglomeration of easily eutectic components such as borneol and menthol during the pulverization process. A matrix dispersion premixing process is adopted, which utilizes the fibrous structure of the plant raw material powder to pre-adsorb liquefied components and block the aggregation of low eutectic substances; combined with low temperature ultrafine pulverization technology, the particle size of the powder is controlled at 80-120 mesh, which not only ensures the continuous stability of the production process, but also significantly increases the specific surface area of ​​the powder, reduces the mass transfer resistance, and realizes the constant rate release of the active ingredients.

[0022] (3) The product of this invention is highly safe and easy to use. All raw materials are natural Chinese medicinal herbs, avoiding the potential irritation to the human respiratory tract and skin caused by chemically synthesized mosquito repellents such as DEET. It is especially suitable for people with allergies. The product is packaged with breathable polypropylene non-woven fabric, which can work without contact with the skin and can meet the long-term use needs of students preparing for exams, drivers staying alert, and outdoor work. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the method flow of the present invention. Detailed Implementation

[0024] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] Please see Figure 1 This invention provides a method for preparing a traditional Chinese medicine composition that repels mosquitoes and refreshes the mind, comprising the following: Preparation Example 1 specifically includes the following steps: Step 1, raw material pretreatment: Select patchouli, artemisia, costus root, clove, vitex leaf, acorus, honeysuckle and magnolia flower, remove impurities and dust by air separation, place them in a hot air circulating drying oven, control the temperature at 45℃±2℃, take them out and let them cool for later use. Step 2, coarse grinding: Mix the patchouli, artemisia leaves, vitex leaves, costus root, cloves, acorus tatarinowii, honeysuckle and magnolia flower according to the formula ratio after step 1, put them into a coarse grinder for preliminary grinding, and make mixed coarse powder with a particle size of 0.5cm to 1.0cm. Step 3, Anti-co-mixing: Take 10% of the total weight of the mixed coarse powder obtained in Step 2 as the dispersion matrix, add the formulated amount of borneol and peppermint, and premix in a mixer. The premixing time can be controlled between 3 and 8 minutes, preferably 5 minutes, so that the borneol and peppermint can be fully dispersed and adsorbed on the surface of the plant coarse powder to obtain the premix. Step 4, ultrafine grinding: Combine the remaining coarse powder from step 2 with the premix obtained in step 3, and put them into an ultrafine grinder. After grinding, all the materials pass through a 100-mesh sieve to obtain mixed powder. Step 5, Homogenization and Packaging: Place the mixed powder obtained in Step 4 into a mixer and mix for 20 minutes; then use an automatic packaging machine to package the powder into polypropylene spunbond nonwoven bags (35g / m²), with the weight of each bag set according to the specific embodiment (ranging from 25g to 50g), heat-seal the bags, and place them in an outer brocade pouch to obtain the final product. Example

[0026] This embodiment provides a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, and its application. This composition is the most preferred formulation, comprising, by weight parts: 10 parts patchouli, 10 parts artemisia argyi, 8 parts costus root, 8 parts clove, 10 parts vitex leaf, 6 parts acorus tatarinowii, 6 parts peppermint, 3 parts honeysuckle, 2 parts borneol, and 2 parts magnolia flower. Its preparation and application form is a traditional Chinese medicine sachet, including the following steps: (1) Weigh out 100g of patchouli, 100g of mugwort, 80g of costus root, 80g of clove, 100g of vitex leaf, 60g of acorus, 60g of mint, 30g of honeysuckle, 20g of borneol and 20g of magnolia flower; (2) Prepared according to the method described in Preparation Example 1; wherein the drying temperature is controlled at 45°C, and the powder is passed through a 100-mesh sieve; (3) In the packaging step, the net content of the medicinal powder in each sachet is set to 30g, and it is packaged in a polypropylene spunbond nonwoven bag. Example

[0027] This embodiment provides a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, and its application. The composition, by weight, comprises: 1 part patchouli, 1 part mugwort, 1 part costus root, 1 part clove, 1 part vitex leaf, 1 part acorus tatarinowii, 1 part peppermint, 1 part honeysuckle, 1 part borneol, and 1 part magnolia flower. Its preparation and application form is a traditional Chinese medicine sachet, including the following steps: (1) Weigh out 10g of patchouli, 10g of mugwort, 10g of costus root, 10g of clove, 10g of vitex leaf, 10g of acorus, 10g of peppermint, 10g of honeysuckle, 10g of borneol and 10g of magnolia flower; (2) Prepared according to the method described in Preparation Example 1; The drying temperature is controlled at 43℃, and the powder is then passed through a 100-mesh sieve. (3) In the packaging step, the net content of the medicinal powder in each sachet is set to 25g, and it is packaged in a polypropylene spunbond nonwoven bag. Example

[0028] This embodiment provides a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, and its application. The composition, by weight, comprises: 15 parts patchouli, 15 parts artemisia argyi, 10 parts costus root, 10 parts clove, 10 parts vitex leaf, 10 parts acorus tatarinowii, 10 parts peppermint, 10 parts honeysuckle, 5 parts borneol, and 5 parts magnolia flower. Its preparation and application form is a traditional Chinese medicine sachet, including the following steps: (1) Weigh out 150g of patchouli, 150g of mugwort, 100g of costus root, 100g of clove, 100g of vitex leaf, 100g of acorus, 100g of peppermint, 100g of honeysuckle, 50g of borneol and 50g of magnolia flower; (2) Prepared according to the method described in Preparation Example 1; The drying temperature is controlled at 47℃, and the powder is then passed through a 100-mesh sieve. (3) In the packaging step, the net content of the medicinal powder in each sachet is set to 50g, and it is packaged in a polypropylene spunbond nonwoven bag. Example

[0029] This embodiment provides a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, and its application. The composition, by weight, comprises: 8 parts patchouli, 8 parts artemisia argyi, 5 parts costus root, 5 parts clove, 8 parts vitex leaf, 5 parts acorus tatarinowii, 5 parts peppermint, 5 parts honeysuckle, 3 parts borneol, and 3 parts magnolia flower. Its preparation and application form is a traditional Chinese medicine sachet, including the following steps: (1) Weigh out 80g of patchouli, 80g of mugwort, 50g of costus root, 50g of clove, 80g of vitex leaf, 50g of acorus, 50g of peppermint, 50g of honeysuckle, 30g of borneol and 30g of magnolia flower; (2) Prepared according to the method described in Preparation Example 1; The drying temperature is controlled at 45℃, and the powder is then passed through a 100-mesh sieve. (3) In the packaging step, the net content of the medicinal powder in each sachet is set to 40g, and it is packaged in a polypropylene spunbond nonwoven bag. Example

[0030] This embodiment provides a traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, and its application. The composition adjusts the proportions of Vitex negundo leaves and other components, and by weight, includes: 12 parts patchouli, 12 parts artemisia argyi, 6 parts costus root, 6 parts clove, 5 parts Vitex negundo leaves, 8 parts acorus tatarinowii, 8 parts peppermint, 6 parts honeysuckle, 2 parts borneol, and 2 parts magnolia flower bud. Its preparation and application form is a traditional Chinese medicine sachet, including the following steps: (1) Weigh out 120g of patchouli, 120g of mugwort, 60g of costus root, 60g of clove, 50g of vitex leaf, 80g of acorus, 80g of peppermint, 60g of honeysuckle, 20g of borneol and 20g of magnolia flower; (2) Prepared according to the method described in Preparation Example 1; The drying temperature is controlled at 46℃, and the powder is then passed through a 100-mesh sieve. (3) In the packaging step, the net content of the medicinal powder in each sachet is set to 35g, and it is packaged in a polypropylene spunbond nonwoven bag.

[0031] To further verify the technical effects of the present invention, the following comparative examples are provided: Comparative Example 1: Compared with Example 1, the difference is that the leaves of Vitex negundo were removed and an equal weight of corn starch (inert filler) was used as a substitute, while the other components and preparation steps were the same.

[0032] Comparative Example 2: Compared with Example 1, the difference is that the leaves of Vitex negundo were replaced with an equal weight of lemongrass (a common mosquito repellent herb), while the other components and preparation steps were the same.

[0033] Comparative Example 3: Compared with Example 1, the difference is that: Acorus tatarinowii, peppermint and borneol (brain-awakening and mind-opening group) were removed, and the amount of patchouli and mugwort was increased accordingly to make up the total weight. The remaining components and preparation steps are the same.

[0034] Comparative Example 4: Compared with Example 1, the difference is that: Artemisia argyi, clove and Vitex negundo leaves (core mosquito repellent group) were removed, and the amount of Acorus calamus and mint was increased accordingly to make up the total weight. The remaining components and preparation steps are the same.

[0035] Comparative Example 5: Prepared according to the method of Preparation Example 1, the only difference is that the ultrafine grinding process in step four is replaced with ordinary grinding so that the final material passes through a 20-mesh sieve, and the other raw material ratios and steps are the same.

[0036] The present invention also provides the following test examples, which mainly verify the stability of the volatilization rate, mosquito repellent effect and brain-refreshing effect of the traditional Chinese medicine composition under specific environmental conditions, and examine the influence of the preparation process (especially the particle size) on the release performance of the active ingredients.

[0037] Test Example 1: Volatility Stability and Release Kinetics Test. Experimental Procedure: Fresh sachet samples prepared in Examples 1, 2, 3, and Comparative Example 5 were selected. Three parallel samples were randomly selected from each group. The outer brocade sachet was removed, leaving only the inner non-woven fabric medicine bag. The samples were placed in a constant temperature test chamber, with the temperature set at 40℃±0.5℃.

[0038] Before the experiment began, each sample was initially weighed using a balance, and the weight was recorded as follows: After the sample is placed in the test chamber, it is taken out and weighed quickly every 24 hours, and the result is recorded as follows. Continuous monitoring was conducted for 7 days, with each weighing process completed within 1 minute. According to the formula... Calculate the cumulative evaporation weight loss rate at each time point, and take the arithmetic mean of 3 parallel samples as the final data for this group.

[0039] Experimental data: The cumulative volatile weight loss rate (%) of each group of samples within the 7-day period is recorded in Table 1.

[0040] Conclusion Analysis Analysis of the test data in Table 1 shows that the cumulative volatilization rate of Example 1 reached 10.11% on day 7, while the data for Comparative Example 5, which used a coarse grinding process, was 4.56% during the same period. The difference in particle size due to physical grinding led to the difference in volatilization performance between the two groups of samples. 100-mesh ultrafine powder increased the specific surface area of ​​the drug and shortened the diffusion path of volatile oil components from the interior of plant tissue to the particle surface; while 20-mesh coarse powder, due to the lower degree of damage to plant cell structure, had greater resistance to mass transfer of internal components, limiting the rapid release of active ingredients in the initial stage.

[0041] Furthermore, although the component dosages and total quantities differed in Examples 1, 2, and 3, the growth trend of their cumulative volatilization curves remained consistent, with the data deviation on day 7 within ±2%. This indicates that the pre-adsorption of plant coarse powders during the anti-co-fusion mixing process prevented powder agglomeration or pore blockage caused by liquefaction of borneol and peppermint during mixing, ensuring the uniformity of the powder structure and the unobstructed release channels. During the 7-day test period, the daily volatilization increment of the sample group in the examples remained at a certain level, without any volatilization stagnation. Borneol acted as a carrier during sublimation, assisting the diffusion of other high-boiling-point components. Simultaneously, the terpenoid components in Vitex negundo leaf and patchouli played a certain role in fixing the aroma, delaying the decline in the overall volatilization rate, allowing the composition to maintain continuous mass loss and active ingredient release within two weeks.

[0042] Test Example 2: Comparative Test of Mosquito Repellent Efficacy In order to verify the mosquito repellent effect of the herbal composition of the present invention and the synergistic effect of Vitex negundo leaf in the formula, the cage trap method in GB / T30126-2013 "Test and Evaluation of Mosquito Repellent Performance of Textiles" was used for the modified test.

[0043] Experimental steps: (1) Test insects: Select Aedes albopictus mosquitoes that have not sucked blood, as they have strong attack power.

[0044] (2) Grouping: Example 1 group, Comparative Example 1 group (without Vitex negundo leaves), Comparative Example 2 group (citronella replaces Vitex negundo leaves), Comparative Example 4 group (without mosquito repellent components) and blank control group (without wearing sachets).

[0045] (3) Procedure: Place 20 test insects in a 30cm×30cm×30cm mosquito cage. Volunteers wear the corresponding group's sachet on their hands and insert them into the mosquito cage for 2 minutes. Record the number of mosquitoes that land on the back of the hand and the exposed area of ​​the forearm. Repeat the test 3 times for each group and take the average value.

[0046] (4) Calculation: Avoidance rate (%) = (average number of landings in the blank control group - average number of landings in the experimental group) / average number of landings in the blank control group × 100%.

[0047] Experimental data: The test data of mosquito repellent effect of each group are shown in Table 2.

[0048] Conclusion Analysis: As shown in Table 2, the repellency rate of Example 1 was as high as 96.4%, which was significantly better than that of Comparative Example 1 (75.7%). This directly proves that Vitex negundo leaf is not an optional auxiliary component. When combined with Artemisia argyi, Patchouli and other components, it significantly improved the repellency activity against Aedes albopictus, producing a synergistic effect of "1+1>2".

[0049] Meanwhile, the repellency rate of Example 1 was also superior to that of Comparative Example 2 (80.8%), which used an equal weight of lemongrass. Although lemongrass is also a commonly used mosquito repellent, in the specific formulation system of this invention, the volatile oil components of Vitex negundo leaves have better binding with the matrix and better odor synergy, demonstrating the specificity and inventiveness of the materials selected in this invention.

[0050] Comparative Example 4 (containing only the stimulating component) had a certain odor (repellency rate of 39.4%), but it could not meet the effective protection standard, proving that the single stimulating component is insufficient to provide adequate mosquito repellency.

[0051] Test Example 3: The test of the brain-awakening and refreshing effect uses the human Schulte grid test method to evaluate the user's concentration and reaction speed after wearing the sachet, in order to verify the brain-awakening effect of the product.

[0052] Experimental steps: (1) Subjects: 30 healthy volunteers were recruited and randomly divided into 3 groups, corresponding to Example 1 group, Comparative Example 3 group (without brain-awakening component) and blank control group respectively.

[0053] (2) Fatigue induction: The test was arranged immediately after the volunteers finished get off work, and the subjects entered the test after a 1-hour boring meeting.

[0054] (3) Test: After wearing the corresponding sachet for 15 minutes, the subjects underwent the Schulte Grid Test (clicking the numbers 1-25 in sequence within a 5x5 grid) and the completion time was recorded. The shorter the time, the more focused the attention and the better the brain-awakening effect. At the same time, the proportion of the average time reduction was calculated with the blank control group as a reference.

[0055] Experimental data: The test results are shown in Table 3. Serial number Example 1 (S) Comparative Example 3 (S) Blank control group (S) 1 26 29 24 2 25 29 36 3 25 26 31 4 21 26 33 5 28 29 40 6 27 23 25 7 29 35 37 8 27 27 35 9 26 29 32 10 24 33 44 Average time (S) 25.8 28.6 33.7 Time reduction 23.44% 15.13% / Table 3. Results of the test on the brain-stimulating and mind-refreshing effects. Conclusion Analysis: As shown in Table 3, after wearing the sachet of Example 1, the average completion time of the subjects was shortened by 23.44%, which was significantly better than that of the blank control group, indicating that the composition has a significant effect of refreshing the mind and improving concentration.

[0056] The time reduction rate of Comparative Example 3 (without borneol, menthol, and calamus) was only 15.13%, indicating that while the scent of the mosquito-repellent components alone has a certain degree of irritation, it lacks the core effect of stimulating the mind and refreshing the spirit. This fully demonstrates that the present invention achieves true dual efficacy through the scientific combination of the mosquito-repellent group and the mind-refreshing group.

[0057] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind, characterized in that, The ingredients include the following parts by weight: 1-15 parts of patchouli, 1-15 parts of mugwort, 1-10 parts of costus root, 1-10 parts of clove, 1-10 parts of vitex leaf, 1-10 parts of acorus calamus, 1-10 parts of peppermint, 1-10 parts of honeysuckle, 1-5 parts of borneol, and 1-5 parts of magnolia flower.

2. The traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind according to claim 1, characterized in that: The raw materials are in the following weight proportions: 5-12 parts of patchouli, 5-12 parts of mugwort, 5-8 parts of costus root, 5-8 parts of clove, 5-10 parts of vitex leaf, 5-8 parts of acorus tatarinowii, 5-8 parts of peppermint, 3-6 parts of honeysuckle, 2-3 parts of borneol, and 2-3 parts of magnolia flower.

3. The traditional Chinese medicine composition for repelling mosquitoes and refreshing the mind according to claim 1, characterized in that: The Vitex leaf is the dried leaf of Vitex negundo, a plant of the Verbenaceae family, and the borneol is synthetic borneol or natural dextrorotatory borneol.

4. The application of the mosquito-repelling and brain-awakening traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The traditional Chinese medicine composition is in powder form, with a powder fineness that passes through an 80-120 mesh sieve. The powder is encapsulated in a polypropylene spunbond nonwoven bag to form a sachet for wearing, and the weight of the powder in each sachet is 25g-50g.

5. A method for preparing a mosquito-repelling and brain-awakening traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, Includes the following steps: Step 1, Raw material pretreatment: Select the above raw materials, remove impurities, and dry them; Step 2, coarse grinding: Mix the remaining ingredients except for borneol and mint in proportion, and perform preliminary grinding to make a mixed coarse powder with a particle size of 0.5cm-1.0cm; Step 3, Preventing Co-mixing: Take 10%-15% of the total weight of the mixed coarse powder obtained in Step 2 as the dispersion matrix, add the formulated amount of borneol and peppermint for premixing, and obtain the premix; Step 4, ultrafine grinding: Combine the remaining coarse powder from step 2 with the premix obtained in step 3, and perform ultrafine grinding to obtain mixed powder. Step 5, Homogenization and Packaging: Homogenize the mixed powder and then package it into breathable packaging materials.

6. The method for preparing a mosquito-repelling and brain-awakening traditional Chinese medicine composition according to claim 5, characterized in that: In step one, the drying process uses hot air circulation drying, and the drying temperature is controlled at 43℃-47℃.

7. The method for preparing a mosquito-repelling and brain-awakening traditional Chinese medicine composition according to claim 5, characterized in that: In step three, the premixing time is 3-8 minutes; After the dispersion matrix adsorbs borneol and peppermint, the borneol and peppermint are dispersed on the surface of the plant powder.

8. The method for preparing a mosquito-repelling and brain-awakening traditional Chinese medicine composition according to claim 5, characterized in that: In step four, the temperature of the grinding chamber is controlled to be <45℃; the fineness of the mixed powder is such that it all passes through a 100-mesh sieve.

9. The method for preparing a mosquito-repelling and brain-awakening traditional Chinese medicine composition according to claim 5, characterized in that: In step five, the breathable packaging material is a polypropylene spunbond nonwoven bag with a basis weight of 30-45 g / m² and a packaging weight of 25-50 g per bag.

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