Radioactive experimental animal administration protection shielding device and workstation comprising same

Abstract

The invention relates to a radioactive experimental animal administration protection shielding device and a workstation comprising the same. The radioactive experimental animal administration protection shielding device comprises a main body frame forming an operation space; the shielding part is fixed on the main body frame and is used for shielding radiation from one or more directions in the operation space; the operation opening is formed in the side part of the main body frame; the base parts of the at least one pair of flexible protective gloves are hermetically fixed at the operation opening and extend into the operation space, and the flexible protective gloves are made of a radiation-proof flexible material; the observation window is arranged at the side part of the main body frame and is made of a transparent anti-radiation material; and the putting-in door and the taking-out door are movably connected to the side part of the main body frame. A multi-directional radiation shielding structure surrounding an operation space is formed through lead plates on the front side face and the rear side face of the main body frame, lead glass on the side portion and a lead plate on the inner side of the taking and placing door, radiation released by radiopharmaceuticals can be effectively isolated, and operators are prevented from being hurt by radiation.

Description

Technical Field

[0001] This invention relates to the field of laboratory animal protective equipment technology, specifically to a radiation-induced drug delivery protective shielding device for laboratory animals and a workstation containing the same. Background Technology

[0002] In experimental research in fields such as medicine and biology, it is often necessary to inject radiopharmaceuticals into laboratory animals such as guinea pigs to conduct experiments related to drug metabolism and disease model construction. However, radiopharmaceuticals continuously release radiation, and if operators directly contact or operate at close range during administration, the radiation can cause harm to their bodies, and long-term exposure may pose health risks. Existing protective methods mostly involve operators wearing personal protective equipment such as lead aprons and lead helmets, but such equipment has the problem of poor flexibility, which can affect the accuracy of drug administration, especially when performing delicate operations such as intravenous injections in guinea pigs, which can easily lead to operational errors. At the same time, some radiation may seep through the gaps in the protective equipment, failing to achieve complete protection and still posing safety hazards. Therefore, there is an urgent need for a device that balances protective effectiveness with ease of operation to overcome the shortcomings of existing technologies. Summary of the Invention

[0003] To address the shortcomings of existing technologies, this invention provides a radiation-protective shielding device for administering drugs to experimental animals and a workstation containing the device, aiming to partially solve the problems of existing technologies.

[0004] To achieve the above objectives, the present invention provides the following technical solution: On the one hand, a radiation-protective shielding device for administering drugs to experimental animals is proposed, comprising: A main framework that constitutes the operating space; Shielding components, which are fixed to the main frame, are used to shield radiation from one or more directions within the operating space; At least one operating port is located on the side of the main frame; At least one pair of flexible protective gloves, the base of which is sealed and fixed to the operating port and extends into the operating space, the flexible protective gloves being made of a radiation-resistant flexible material; The observation window, located on the side of the main frame, is made of transparent radiation-proof material; It also includes an insertion door and an retrieval door, which are movably connected to the side of the main frame and are used to open and close to retrieve and place laboratory animals.

[0005] As a preferred technical solution, the shielding component includes: a first lead plate fixed around the main frame; and a second lead plate fixed inside the insertion door and the removal door; wherein the observation window is made of lead glass and is sealed and fixed to the side of the main frame.

[0006] As a preferred technical solution, the telescopic platform is used to support the main frame and adjust its height.

[0007] As a preferred technical solution, a drawer-type tray is provided at the bottom of the main frame, and lead plates are embedded in at least the bottom and side walls of the drawer-type tray.

[0008] As a preferred technical solution, the upper surface of the drawer-type tray is covered with a disposable sterile pad or an absorbent material layer.

[0009] As a preferred technical solution, the insertion door and the removal door are symmetrically arranged on two opposite sides of the main frame, which are not the sides where the operation port is located.

[0010] As a preferred technical solution, it also includes a lighting system and a camera system integrated into the operating space.

[0011] As a preferred technical solution, the flexible protective glove has a double-layer structure, including an inner butyl rubber layer and an outer lead-containing polyethylene layer.

[0012] As a preferred technical solution, a radiation dose monitor is also included, with the detector head of the radiation dose monitor installed on the four walls outside the protective shielding device.

[0013] On the other hand, a laboratory radiopharmaceutical operation workstation is proposed, including: a radioactive experimental animal drug administration protective shielding device as described above, with the protective shielding device serving as the core operation unit. A pre-positioning table, adjacent to the insertion door, is used for the temporary placement of laboratory animals to be injected and radiopharmaceuticals; And a rear observation cage, adjacent to the removal door, for placing the experimental animals after injection.

[0014] Compared with the prior art, the technical solution of this application has the following beneficial effects: (1) Comprehensive protection: The lead plates on the front and back sides of the main frame, the lead glass on the side, and the lead plate on the inside of the access door form a multi-directional radiation shielding structure around the operating space, which can effectively isolate the radiation released by the radioactive drug and prevent the operator from being harmed by radiation. The protection effect is significantly better than that of traditional personal protective equipment.

[0015] (2) Convenient operation: The glove device is made of flexible radiation-proof material, allowing operators to directly insert their hands into the device to perform drug administration. The hand is flexible and does not affect the accuracy of delicate operations such as intravenous injection. At the same time, the lead glass on the side ensures a clear operating view, making it easy for operators to observe the guinea pig's condition and operating position, and reducing the error rate.

[0016] (3) Simple and practical structure: The device is composed of basic components such as main frame, lead plate, lead glass, glove device, etc. It has a simple structure and low manufacturing cost. The telescopic platform ensures the stability of the device and the flexibility of height adjustment. The door facilitates the handling of guinea pigs and is easy to promote and apply in the laboratory. Attached Figure Description

[0017] Figure 1 This invention provides a schematic diagram of a radiation-protective shielding device for administering drugs to experimental animals. Figure 1 ; Figure 2 This invention provides a schematic diagram of a radiation-protective shielding device for administering drugs to experimental animals. Figure 2 ; Figure 3 This is a cross-sectional structural diagram of the main frame proposed in this invention.

[0018] Explanation of reference numerals in the attached drawings: 1. Main frame; 2. Operating port; 3. Observation window; 4. Telescopic platform; 5. Base; 6. Scissor arm; 7. Hydraulic system; 9. Drawer tray; 91. Sterile mat; 10. Lighting system; 11. Camera system; 12. Pre-preparation table; 13. Insertion door; 14. Removal door; 15. Observation cage; 16. Push handle; 17. Casters; 18. Radiation dose monitor. Detailed Implementation

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] like Figure 1-3 As shown, on the one hand, a radiation-induced drug delivery protective shielding device for experimental animals is proposed, comprising: A radiation-protective shielding device for administering drugs to laboratory animals, comprising: A main framework constituting the operating space; A shielding component, fixed to the main frame 1, is used to shield radiation from one or more directions within the operating space; At least one operating port 2 is provided on the main frame 1. For example... Figure 1-3 As shown, the structure of two operating ports 2 is illustrated, allowing for simultaneous operation by two people. Each operating port 2 includes two operating inlets, facilitating simultaneous access by both hands. The distance between the two operating inlets can be set to approximately 0.4 meters. The diameter of the operating inlets can be set to approximately 14-15 centimeters.

[0021] At least one pair of flexible protective gloves, the base of which is sealed and fixed at the operating port 2 and extends into the operating space, the flexible protective gloves being made of radiation-resistant flexible material.

[0022] The observation window 3, located on the side of the main frame 1, is made of transparent radiation-proof material; and the insertion door 13 and the retrieval door 14 are movably connected to the side of the main frame 1 for opening and closing to place and retrieve experimental animals. The length of the observation window 3 can be set between 0.3 and 0.4 meters.

[0023] Preferably, the shielding components include: a first lead plate fixed around the perimeter of the main frame 1; and a second lead plate fixed inside the insertion door 13 and the removal door 14; wherein the observation window 3 is made of lead glass and is sealed to the side of the main frame 1. The lead glass is sealed to the side of the main frame 1 to ensure that the operator can clearly observe the situation in the operating space, while shielding the ocular radiation dose in the side observation direction.

[0024] Preferred, such as Figure 1 As shown, a height-adjustable telescopic platform 4 is fixedly connected to the bottom of the main frame 1. The telescopic platform 4 supports the entire main frame 1, keeping the device stable; at the same time, by adjusting the height of the telescopic platform 4, it can accommodate different operators' heights, making operation more comfortable. Figure 1-2 As shown, the telescopic platform 4 can be a scissor lift structure, including: a base 5, with a scissor arm 6 connected above the base 5, and the bottom of the main frame 1 connected above the scissor arm 6; a hydraulic system 7, including a linkage structure and a hydraulic cylinder, used to drive the lifting and lowering of the scissor arm 6; and a control system, used to control the motor to drive the hydraulic system 7, causing the scissor arm 6 to extend and retract, adjusting the height of the main frame 1 to suit operators of different heights. The telescopic platform 4 can be raised to approximately 1.1 meters, and the overall device height can reach 1.8 meters, allowing operators to work while seated or standing.

[0025] Preferred, such as Figure 1-3 As shown, a drawer-type tray 9 is provided at the bottom of the main frame 1, and lead plates are embedded in at least the bottom and side walls of the drawer-type tray 9.

[0026] For the best options, please continue to refer to them. Figure 1-3 The upper surface of the drawer-type tray 9 is covered with a disposable sterile pad 91 or an absorbent material layer. Specifically, the structure of the drawer-type tray 9 differs from traditional drawer structures. Traditional drawers have recesses for placing items, while this drawer-type tray 9 is a solid drawer without recesses. The upper surface of the drawer is covered with a sterile pad 91 or an absorbent material layer, solving the problems of contamination and cleaning caused by animal excrement and medication spills. The design of the disposable sterile pad 91 or absorbent layer further enhances the hygiene and convenience of the device.

[0027] Preferably, not shown in the figure, it may also include a ventilation and filtration system, which includes: an air inlet and an air outlet disposed on the main frame 1; a pre-filter covering the air inlet and the air outlet; and an activated carbon filter disposed at the rear end of the air outlet; wherein the ventilation and filtration system constitutes a unidirectional airflow from the air inlet to the air outlet.

[0028] Preferred, such as Figure 3 As shown, it also includes a lighting system 10 and a camera system 11 integrated within the operating space. The addition of the "lighting and camera system 11" enhances the device's modernity and versatility. The internal lighting eliminates shadows and improves viewing clarity; the camera system 11 can be used to record operating procedures, for teaching, or for remote guidance.

[0029] Preferably, the flexible protective glove has a double-layer structure, including an inner butyl rubber layer and an outer lead-containing polyethylene layer.

[0030] Preferably, it also includes a radiation dose monitor 18, whose probes are mounted on the four walls outside the protective shielding device, and whose display unit is located outside the main frame 1. It can provide real-time feedback on the protective effect, warn of potential leaks, and provide important psychological and safety assurance for operators.

[0031] Preferably, in order to facilitate the movement of the shielding device, four casters 17 are provided under the base 5, and push handles 16 are also provided on the side of the telescopic platform 4, with anti-slip devices provided on the push handles 16.

[0032] On the other hand, the present invention also proposes a laboratory radiopharmaceutical operation workstation, including: a radioactive experimental animal drug administration protective shielding device as described above, wherein the protective shielding device serves as the core operation unit. A pre-preparation table 12, adjacent to the insertion door 13, is used to temporarily place experimental animals to be injected and radiopharmaceuticals. And a rear observation cage 15, adjacent to the removal door 14, is used to place the experimental animal after injection. After the animal is injected, it can be placed in the observation cage 15 for radioactivity monitoring and evaluation.

[0033] Example The present invention will be further illustrated below with reference to specific embodiments. However, these examples are merely illustrative and are not intended to limit the scope of the invention.

[0034] 1. Materials and Methods 1.1 Experimental Animals The animal selected in this embodiment is an SPF-grade Hartley guinea pig.

[0035] 1.2 Administration method In this embodiment, 177Lu radionuclide was dissolved in physiological saline and then injected intravenously into Hartley guinea pigs, with an activity of 20 mCi.

[0036] 1.3 Guinea Pig Drug Administration Protective Shielding Device The guinea pig drug administration protective shielding device described in this embodiment is made of stainless steel, lead plate, and lead glass. Because the nuclide 177Lu used in this embodiment emits beta rays, lead plate is selected as the enclosure. The front, back, and sides of the guinea pig drug administration protective shielding device are all made of lead plates, with the front lead plate equipped with a glove device. The sides of the guinea pig drug administration protective shielding device can be made of lead glass, positioned above the operating port 2. The lead glass has a certain slope for easier observation by the operator. The lead glass has a height of 28.5 cm and a thickness of 0.5 mmPb. Furthermore, the guinea pig drug administration protective shielding device has a regular and symmetrical shape; the base area of ​​the guinea pig drug administration protective shielding device is 0.72 m². 2 The height is 0.9-1.2m; the height of the main frame 1 can be adjusted according to the height of the operator by means of the telescopic platform 4.

[0037] 1.4 Evaluation Method for the Protective Effect of Drug Administration Shielding Devices on Guinea Pigs The evaluation method includes the following steps: S1. Place the Hartley guinea pig into the protective shielding device through the insertion door 13. Inject the experimental Hartley guinea pig with 177Lu radionuclide through the operating port 2. Since 177Lu radionuclide releases beta rays, a lead plate is selected as the shielding device. Monitor or read the values ​​of the radiation monitor using a handheld environmental dose monitor to obtain the radioactivity around the drug delivery device. Record three values ​​for each side and take the average value.

[0038] S2. Remove the Hartley guinea pig from the removal door 14 and place it in the observation cage 15. Use a handheld environmental dose monitor to monitor the radioactivity around the observation cage 15. Record three values ​​for each side and take the average value.

[0039] S3. Evaluate the protective effect of the guinea pig drug administration shielding device by comparing the data of its radioactivity in two separate tests.

[0040] 2. Results of the protective effect of the drug administration shielding device for guinea pigs After placing Hartley guinea pigs inside a drug administration shielding device, radioactive 177Lu (20 mCi) was dissolved in physiological saline and injected intravenously into the guinea pigs. The mean radioactivity around the drug administration shielding device was monitored, ranging from 0.613 to 1.876 μSv / h. The injected Hartley guinea pigs were then removed from the extraction door 14 and placed in observation cage 15. The mean radioactivity around the observation cage 15 was measured using a handheld environmental dosimeter, ranging from 19.723 to 29.242 μSv / h. Comparing the two sets of data, it is evident that placing Hartley guinea pigs inside the drug administration shielding device significantly reduced individual radioactivity. Detailed data are shown in Table 1.

[0041] Table 1. Protection Results of the Drug Administration Shielding Device for Guinea Pigs (μSv / h)

[0042] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A radiation-protective shielding device for administering drugs to experimental animals, characterized in that, include: A main framework that constitutes the operating space; A shielding component, fixed to the main frame, is used to shield radiation from one or more directions within the operating space; At least one operating port is provided on the side of the main frame; At least one pair of flexible protective gloves, the base of which is sealed and fixed to the operating port and extends into the operating space, the flexible protective gloves being made of a radiation-resistant flexible material; An observation window, located on the side of the main frame, is made of transparent radiation-proof material; The system includes an insertion door and an retrieval door, which are movably connected to the side of the main frame and are used to open and close to retrieve and place laboratory animals.

2. The radiation-induced drug delivery protective shielding device for experimental animals according to claim 1, characterized in that, The shielding component includes: a first lead plate fixed around the main frame; and a second lead plate fixed inside the insertion door and the removal door; wherein the observation window is made of lead glass and is sealed to the side of the main frame.

3. The radiation-induced experimental animal drug delivery protective shielding device according to claim 2, characterized in that, The bottom of the main frame is fixedly connected to a height-adjustable telescopic platform, which is used to support the main frame and adjust its height.

4. The radiation-induced drug delivery protective shielding device for experimental animals according to claim 1, characterized in that, The bottom of the main frame is provided with a drawer-type tray, and at least the bottom and side walls of the drawer-type tray are inlaid with lead plates.

5. The radiation-induced experimental animal drug delivery protective shielding device according to claim 4, characterized in that, The upper surface of the drawer-type tray is covered with a disposable sterile pad or an absorbent material layer.

6. The radiation-induced drug delivery protective shielding device for experimental animals according to claim 1, characterized in that, The insertion door and the removal door are symmetrically arranged on two opposite sides of the main frame, which are not the sides where the operation port is located.

7. The radiation-induced experimental animal drug delivery protective shielding device according to claim 1, characterized in that, It also includes a lighting system and a camera system integrated within the operating space.

8. The radiation-induced experimental animal drug delivery protective shielding device according to claim 1, characterized in that, The flexible protective gloves have a double-layer structure, consisting of an inner butyl rubber layer and an outer lead-containing polyethylene layer.

9. The radiation-induced experimental animal drug delivery protective shielding device according to claim 1, characterized in that, It also includes a radiation dose monitor, the probe of which is mounted on the four walls outside the protective shielding device.

10. A laboratory radiopharmaceutical handling workstation, characterized in that, include: The radiation-induced experimental animal drug delivery protective shielding device as described in any one of claims 1 to 9, wherein the protective shielding device is a core operating unit; A pre-positioning preparation table, adjacent to the insertion door, is used for temporarily placing experimental animals and radiopharmaceuticals to be injected; And a rear observation cage, adjacent to the removal door, for placing the injected experimental animal.

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