Pesticide composition and application thereof

Abstract

The invention relates to the technical field of pesticides, and discloses a pesticide composition and application thereof. The effective active components of the pesticide composition comprise thiamethoxam and deltamethrin, and the weight ratio of thiamethoxam to deltamethrin is (39: 5)-(1: 1), and optionally (39: 5)-(29: 5). The pesticide composition disclosed by the invention is combined and used according to a ratio to be prepared into a microcapsule suspension-suspending agent, has a more remarkable prevention and treatment effect, can effectively prevent and treat spinach aphids, is quick-acting and lasting, can better solve the problems of strong pesticide irritation and easiness in causing skin pain and itching in the pharmaceutical and use processes, can also reduce the cost, and has a good application prospect. The pollution of pesticide residues to the environment is reduced, the usability is improved, and pesticide poisoning accidents are reduced.

Description

Technical Field

[0001] This invention belongs to the field of pesticide technology, specifically relating to a pesticide composition and its application. Background Technology

[0002] Thiamethoxam is a novel, second-generation neonicotinoid insecticide with highly effective and low-toxicity properties. It exhibits stomach poison, contact, and systemic activity against pests and is used for foliar spraying and soil drenching. After application, it is rapidly absorbed systemically and translocated to all parts of the plant, providing excellent control of piercing-sucking pests such as aphids, planthoppers, leafhoppers, and whiteflies.

[0003] Deltamethrin belongs to the pyrethroid insecticide class and is one of the most toxic pyrethroid insecticides, classified as a moderately toxic substance. It has both contact and stomach poison effects; contact action is rapid and has a strong knockdown effect. Skin contact can cause irritation symptoms, such as red papules. Acute poisoning can cause headache, dizziness, nausea, vomiting, loss of appetite, and fatigue in mild cases, and muscle fasciculations and convulsions in severe cases. It is irritating to human skin and mucous membranes and is highly toxic to fish and bees.

[0004] Besides diseases, aphids are the most troublesome pest in vegetable cultivation. Aphids are highly resistant and extremely difficult to control. Aphids typically have about 20 generations per year, often clustering densely on the undersides of leaves, primarily feeding on sap. This causes severe dehydration and malnutrition, slowing growth and, in severe cases, halting it altogether. Infested leaves curl, turn yellow, and become deformed; tender stems and flower stalks also deform, affecting fruit set. In addition to directly damaging vegetables, the large amounts of honeydew excreted by aphids negatively impact both yield and quality. Furthermore, aphids are major vectors of various viral diseases, rapidly transmitting viruses from infected vegetables to healthy plants. The losses caused by viral diseases transmitted by aphids are no less than those caused by aphids themselves. Aphids are also heavily influenced by natural enemies.

[0005] With the increase in greenhouse vegetable cultivation, growers' pesticide use habits and indiscriminate application often result in the mixing of multiple pesticides, leading to increasingly larger amounts of pesticides used. This has a strong killing effect on aphid natural enemies, causing aphids to become uncontrollable by the weather. As the amount of pesticides used increases, pests and diseases develop stronger resistance. Furthermore, pesticide residues and bacteria and viruses are difficult to wash off during the consumption process. Therefore, how to reduce pesticide residues, reduce viral transmission, reduce pesticide use, and ensure environmental and human safety are urgent problems that need to be solved.

[0006] The applicant has combined two pesticides with completely different mechanisms of action, encapsulating deltamethrin in a polymeric material capsule. This solves the problems of deltamethrin's high toxicity and safety concerns for personnel, while also addressing crop lesions caused by aphids. It improves pesticide deposition, adhesion, and penetration on leaves, increases pesticide utilization, and enhances compatibility with other pesticides, offering multiple therapeutic effects with a single pesticide, as well as rapid and sustained efficacy. Therefore, the combination of thiamethoxam and deltamethrin is worthy of widespread application in agricultural production. Summary of the Invention

[0007] Purpose of the invention

[0008] The purpose of this invention is to provide a pesticide composition and its application, which can effectively control aphids on vegetables and has the advantages of being safe and environmentally friendly, having low residue, low dosage, fast-acting, long-lasting effect, and being safe for personnel.

[0009] Solution

[0010] To achieve the objective of this invention, this embodiment provides a pesticide composition in which the effective active ingredients are thiamethoxam and deltamethrin, and the weight ratio of thiamethoxam to deltamethrin is 39:5 to 1:1, optionally 39:5 to 29:5, optionally 39:5. The pesticide composition is formulated as a microcapsule suspension.

[0011] Furthermore, the thiamethoxam and deltamethrin constitute 5.5% to 44% of the total weight of the composition, optionally 11% to 33%, and optionally 22%.

[0012] Furthermore, the pesticide composition further includes excipients, which optionally include one or more of the following: capsule wall material, dispersant, wetting agent, emulsifier, solvent, antifreeze, thickener, defoamer, pH adjuster, and preservative.

[0013] Furthermore, the capsule wall material is selected from one or more of isocyanates, organic amines, and polyols. The isocyanate is selected from one or two of isophorone diisocyanate, toluene-3,5-diisocyanate, diphenylmethane diisocyanate, triphenylmethane triisocyanate, 3,3′-dimethoxy-4,4′-biphenyl diisocyanate, or isophenyl dimethyl isocyanate. The organic amine is selected from one or two of 1,6-hexanediamine, triethylenetetramine, 1,3-propanediamine, or ethylenediamine.

[0014] Furthermore, the dispersant is selected from one or more of the following: alkylnaphthalene formaldehyde condensate sulfonate, alkylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether sulfonate, phenethylphenol polyoxyethylene ether phosphate, alkyl polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene ether block copolymer, dispersant, dodecyl polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, naphthalene sulfonate formaldehyde condensate sodium salt block copolymer, comb-type polycarboxylate, sodium polycarboxylate, and lignin sulfonate.

[0015] Furthermore, the wetting agent is selected from one or more of the following: alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, alkyl naphthalene sulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, triphenylethylphenol polyoxypropylene polyoxyethylene block polymer, sodium dodecyl sulfate, styrene-based phenol formaldehyde resin propylene oxide block polyether, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, alkyl glycoside, and sodium fatty alcohol polyoxyethylene ether sulfonate.

[0016] Furthermore, the emulsifier is selected from one or more of the following: calcium dodecylbenzenesulfonate, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether, polyol fatty acid ester and its ethylene oxide adduct, and polyoxyethylene polyoxypropylene block copolymer.

[0017] Furthermore, the solvent is selected from one or more of cyclohexanone, 200# solvent oil, 150# solvent oil, aliphatic hydrocarbon solvent oil, vegetable oil, and xylene.

[0018] Furthermore, the antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol, isopropanol, urea, polyethylene glycol, and sorbitol.

[0019] Furthermore, the preservative is sodium benzoate.

[0020] Furthermore, the defoamer is a silicone defoamer, a C10-20 saturated fatty acid compound, a C8-10 fatty alcohol, hexanol, butanol, or octanol.

[0021] Furthermore, the pH adjuster is selected from one or more of glacial acetic acid and citric acid.

[0022] Furthermore, the thickener is selected from one or more of xanthan gum, magnesium aluminum silicate, silica, and polyvinyl alcohol.

[0023] Furthermore, the capsule wall material accounts for 0.1% to 5% of the pesticide composition by weight, and optionally 0.5% to 3%.

[0024] Furthermore, the dispersant accounts for 1% to 10% of the pesticide composition by weight, optionally 2% to 7%.

[0025] Furthermore, the wetting agent accounts for 0.5% to 5% of the pesticide composition by weight, optionally 0.5% to 3%.

[0026] Further, the emulsifier accounts for 0.5% to 8% of the pesticide composition by weight, optionally 0.5% to 3%, optionally 0.8% to 1.5%.

[0027] Furthermore, the antifreeze accounts for 1% to 6% of the weight percentage of the pesticide composition, optionally 3% to 5%.

[0028] Furthermore, the solvent accounts for 3% to 45% of the pesticide composition by weight, optionally 10% to 30%, and optionally 15% to 25%.

[0029] Further, the thickener accounts for 0.05% to 2% of the pesticide composition by weight, optionally 0.1% to 1%.

[0030] Furthermore, the pH adjuster accounts for 0-1.5% of the pesticide composition by weight, optionally 0-1% pH.

[0031] Furthermore, the preservative accounts for 0-1% of the pesticide composition by weight, optionally 0.1%-0.8%.

[0032] Furthermore, the defoamer accounts for 0-1% of the pesticide composition by weight, optionally 0-0.5%.

[0033] Furthermore, the water content in the pesticide composition is 30% to 70% by weight, optionally 35% to 60%, and optionally 40% to 50%.

[0034] Furthermore, the preparation method of the pesticide composition is as follows: first, prepare thiamethoxam suspension, then prepare deltamethrin microcapsule suspension, and finally mix and modulate the intermediates to prepare thiamethoxam·deltamethrin microcapsule suspension-suspension.

[0035] Furthermore, the preparation method includes the following steps:

[0036] (1) The preparation method of thiamethoxam suspension is as follows: water, thickener, antifreeze, emulsifier, dispersant and defoamer are added in sequence and sheared and stirred evenly. The weighed thiamethoxam technical material is added and sheared and stirred to form a sand mill slurry. After graded sand milling, the sand milled slurry is pumped into the preparation tank. The sand mill is cleaned with the remaining purified water and then put into the preparation tank. At the same time, preservative and defoamer are added and stirred evenly for use.

[0037] (2) The preparation method of deltamethrin microcapsule suspension is as follows: the deltamethrin technical material is completely dissolved in solvent, and then the encapsulating agent and emulsifier are added and stirred evenly to prepare the oil phase of deltamethrin microcapsule suspension for later use; then a certain amount of water is taken, and pH adjuster, emulsifier and defoamer are added and stirred evenly to prepare the aqueous phase of deltamethrin microcapsule suspension for later use; after the oil and water phases are prepared, the prepared oil phase is slowly added to the aqueous phase and stirred and sheared, then the encapsulating agent is added and stirred to solidify into capsules;

[0038] (3) Take the qualified thiamethoxam suspension and deltamethrin microcapsule suspension respectively, mix and stir to obtain thiamethoxam·deltamethrin microcapsule suspension-suspension.

[0039] Furthermore, the application of the thiamethoxam·deltamethrin microcapsule suspension in the control of crop pests includes thrips, aphids, leafhoppers, whiteflies, and planthoppers, optionally spinach aphids.

[0040] Furthermore, the thiamethoxam·deltamethrin microcapsule suspension-suspension agent is used to control aphids. It is applied once as a spray during the initial and peak period of aphid infestation, with a water volume of 600-750 liters / hectare and an effective active ingredient dosage of 12-35 grams / hectare. The optional dosage is 15.3-26.4 grams / hectare, and the optional dosage is 19.8-26.4 grams / hectare.

[0041] Compared with the prior art, the compositions of the present invention have the following beneficial effects:

[0042] (1) Compared with single-dose, it has both rapid and sustained effects, and its control effect is significantly better than that of the control single-dose, with extremely significant differences.

[0043] (2) It is beneficial to the chemical stability of the active ingredients. Encasing pesticides in a shell can not only avoid the loss of efficacy caused by high volatility, but also reduce toxicity and prevent poisoning accidents caused by contact with the pesticide by producers or users.

[0044] (3) It is environmentally safe and has low toxicity to aquatic organisms such as bees, fish, and silkworms. Detailed Implementation

[0045] The present invention will be further described below with reference to embodiments, but the present invention is not limited thereto.

[0046] Application Example 1 The pesticide compositions in the following examples contain the following components in percentage weight:

[0047] Example 1: 22% Thiamethoxam·Deuterium Cypermethrin Microcapsule Suspension - Suspension Agent

[0048] The raw material composition based on 100 parts by weight of pesticide composition is as follows: 19.5 parts by weight of thiamethoxam, 2.5 parts by weight of deltamethrin, 1.2 parts by weight of isocyanate, 0.2 parts by weight of polyol, 4 parts by weight of alkylnaphthalene formaldehyde condensate sulfonate, 1.2 parts by weight of phenethylphenol polyoxyethylene ether phosphate, 1 part by weight of fatty alcohol polyoxyethylene ether, 18 parts by weight of 200# solvent oil, 2 parts by weight of cyclohexanone, 4 parts by weight of ethylene glycol, 0.3 parts by weight of sodium benzoate, 0.2 parts by weight of silicone defoamer, 0.1 parts by weight of glacial acetic acid, 0.15 parts by weight of xanthate gum, and water as balance.

[0049] Example 2: 22% Thiamethoxam·Deuterium Cypermethrin Microcapsule Suspension - Suspension Agent

[0050] The raw material composition based on 100 parts by weight of pesticide composition is as follows: 19.5 parts by weight of thiamethoxam, 2.5 parts by weight of deltamethrin, 1.5 parts by weight of isocyanate, 0.1 parts by weight of organic amine, 2 parts by weight of polyoxyethylene polyoxypropylene ether block copolymer, 1 part by weight of alkyl naphthalene sulfonate, 1 part by weight of sodium dodecyl sulfate, 0.9 parts by weight of fatty alcohol polyoxyethylene ether phosphate, 15 parts by weight of aliphatic hydrocarbon solvent oil, 3 parts by weight of cyclohexanone, 5 parts by weight of xylene, 3 parts by weight of glycerol, 0.3 parts by weight of sodium benzoate, 0.4 parts by weight of hexanol, 0.2 parts by weight of citric acid, 1 part by weight of magnesium aluminum silicate, and water as balance.

[0051] Example 3: 22% Thiamethoxam·Deuterium Cypermethrin Microcapsule Suspension-Suspension Agent

[0052] The raw material composition based on 100 parts by weight of pesticide composition is as follows: 19.5 parts by weight of thiamethoxam, 2.5 parts by weight of deltamethrin, 1.4 parts by weight of isocyanate, 0.4 parts by weight of organic amine, 3 parts by weight of alkylphenol polyoxyethylene ether phosphate, 1 part by weight of sodium fatty alcohol polyoxyethylene ether sulfonate, 0.8 parts by weight of alkyl glycoside, 1.5 parts by weight of calcium dodecylbenzenesulfonate, 20 parts by weight of 200# solvent oil, 5 parts by weight of vegetable oil, 5 parts by weight of propylene glycol, 0.4 parts by weight of sodium benzoate, 0.5 parts by weight of C8-10 fatty alcohols, 0.2 parts by weight of glacial acetic acid, 1.3 parts by weight of silica, and water as balance.

[0053] Example 4: 11% Thiamethoxam·Deuterium Cypermethrin Microcapsule Suspension-Suspension Agent

[0054] The raw material composition based on 100 parts by weight of pesticide composition is as follows: 9.75 parts by weight of thiamethoxam, 1.25 parts by weight of deltamethrin, 1.2 parts by weight of isocyanate, 0.3 parts by weight of polyol, 2 parts by weight of fatty alcohol polyoxyethylene ether phosphate, 1 part by weight of sodium dodecyl sulfate, 0.7 parts by weight of alkylphenol polyoxyethylene ether, 15 parts by weight of 150# solvent oil, 4 parts by weight of ethylene glycol, 0.2 parts by weight of sodium benzoate, 0.2 parts by weight of silicone defoamer, 0.4 parts by weight of citric acid, 0.3 parts by weight of polyvinyl alcohol, and water as balance.

[0055] Example 5: 33% Thiamethoxam·Deuterium Cypermethrin Microcapsule Suspension-Suspension Agent

[0056] The raw material composition based on 100 parts by weight of pesticide composition is as follows: 29.25 parts by weight of thiamethoxam, 3.75 parts by weight of deltamethrin, 1.5 parts by weight of isocyanate, 0.5 parts by weight of organic amine, 3 parts by weight of comb-type polycarboxylate, 1.7 parts by weight of alkylphenol formaldehyde resin polyoxyethylene ether, 1.3 parts by weight of polyoxyethylene polyoxypropylene block copolymer, 25 parts by weight of 200# solvent oil, 5 parts by weight of cyclohexanone, 5 parts by weight of isopropanol, 0.25 parts by weight of sodium benzoate, 0.1 parts by weight of C10-20 saturated fatty acid compound, 0.7 parts by weight of glacial acetic acid, 0.1 parts by weight of xanthate gum, 0.4 parts by weight of silica, and water as balance.

[0057] Example 6: 34% Thiamethoxam·Deuterium Cypermethrin Microcapsule Suspension-Suspension Agent

[0058] The raw material composition based on 100 parts by weight of pesticide composition is as follows: 29 parts by weight of thiamethoxam, 5 parts by weight of deltamethrin, 1.3 parts by weight of isocyanate, 0.4 parts by weight of organic amine, 4 parts by weight of alkyl polyoxyethylene ether sulfonate, 1.1 parts by weight of castor oil polyoxyethylene ether, 0.3 parts by weight of fatty alcohol polyoxyethylene ether, 1.2 parts by weight of calcium dodecylbenzenesulfonate, 25 parts by weight of 200# solvent oil, 10 parts by weight of aliphatic hydrocarbon solvent oil, 3 parts by weight of glycerol, 0.4 parts by weight of sodium benzoate, 0.3 parts by weight of silicone defoamer, 0.5 parts by weight of glacial acetic acid, 0.7 parts by weight of magnesium aluminum silicate, and water as balance.

[0059] The control single agent 1, 25% thiamethoxam water-dispersible granules, was commercially available.

[0060] The control agent was 25 g / L deltamethrin emulsifiable concentrate, which was commercially available.

[0061] Implementation Example 2:

[0062] Indoor Combined Toxicity Determination Experiment of Thiamethoxam, Deltamethrin and Mixed Pairs on Spinach Aphids 1. Experimental Objective

[0063] The toxicity of thiamethoxam and deltamethrin, and their different mixtures, to spinach aphids was determined in the laboratory, and their synergistic effect was evaluated to clarify their compatibility and provide a scientific basis for the research and development of thiamethoxam and deltamethrin mixtures.

[0064] 2 Experimental conditions

[0065] 2.1 Test Target

[0066] Spinach aphids (Myzus persicae (Sulzer)) were used as targets in the experiment, which were young larvae that had naturally multiplied through multiple generations on spinach grown in the experimental base that had never been treated with pesticides.

[0067] 2. Cultivation conditions

[0068] The culture conditions for the test targets and the targets after the experiment were: temperature (25±1)℃, relative humidity 60%~80%, and photoperiod L∶D=(16∶8)h.

[0069] 3 Experimental Design

[0070] 3.1 Test reagents

[0071] Thiamethoxam 98% technical grade; deltamethrin 98% technical grade.

[0072] 3.2 Reagent Preparation

[0073] Weigh 0.0102g of 98% deltamethrin technical grade, dissolve it in 0.5mL of DMF, add 0.2mL of Tween 80 emulsifier, stir well, add water to 100mL to prepare a 100mg / L stock solution. Then take 4mL of the stock solution and add it to 96mL of water containing 0.1% Tween 80 emulsifier to prepare a 4mg / L test solution. Then dilute it with water containing 0.1% Tween 80 emulsifier at a ratio of 2 to prepare 2, 1, 0.5, 0.25 and 0.125mg / L, for a total of 6 concentrations for testing.

[0074] Weigh 0.0102 g of 98% thiamethoxam technical grade, dissolve it in 2 mL of LDM, add 0.2 mL of Tween 80 emulsifier, stir well, add water to 100 mL to prepare a 100 mg / L stock solution. Take 8 mL of the stock solution and add it to 92 mL of water containing 0.1% Tween 80 emulsifier to prepare an 8 mg / L test solution. Then dilute it with water containing 0.1% Tween 80 emulsifier at a ratio of 2 to prepare 4, 2, 1, 0.5 and 0.25 mg / L, for a total of 6 concentrations for testing.

[0075] According to the ratios of thiamethoxam to deltamethrin of 49:5, 39:5, 29:5, 5:5 and 5:29, 7.26, 7.09, 6.82, 2 and 0.59 mL of thiamethoxam mother liquor were respectively measured, and then the corresponding amounts of 0.74, 0.91, 1.18, 2 and 3.41 mL of deltamethrin mother liquor were taken. The two were mixed, and water containing emulsifier was added to make up to 100 mL, and test solutions of 8, 8, 8, 4 and 4 mg / L were respectively prepared. Then they were respectively diluted by a factor of 2 with water containing 0.1% Tween80 emulsifier to 6 concentrations for the experiment.

[0076] Add 98 mL of water containing 0.1% Tween80 emulsifier to a beaker containing 2 mL of DMF as a blank control.

[0077] 4 Test method

[0078] Referring to the Guidelines for Indoor Bioassay of Pesticides NY / T1154.6 - 2006, the insect - dipping method was adopted. 30 healthy and consistent spinach aphids were used for each replicated treatment, with 4 replicates for each treatment, and a treatment without the pesticide (including the used solvent and emulsifier) was set as a blank control. After the treatment, they were placed in an observation room for cultivation.

[0079] 5 Data investigation and statistical analysis

[0080] 5.1 Investigation time and method

[0081] After 48 h, the death situation of the test insects was checked and recorded. The criterion for judging the death of the test insects was that there was no response when gently touching the test insects with a pointed writing brush, which was counted as death.

[0082] 5.2 Data statistical analysis

[0083] Referring to the Guidelines for Indoor Bioassay of Pesticides NY / T1154.7 - 2006, the co - toxicity coefficient (CTC) of each mixture combination was calculated by the Sun & Johnson (1960) co - toxicity coefficient method. CTC ≤ 80 indicates antagonism, 80 < CTC < 120 indicates additive effect, and CTC ≥ 120 indicates synergistic effect. The formula for calculating the co - toxicity coefficient is as follows:

[0084]

[0085] The theoretical toxicity index (TTI) of the mixture = the toxicity index of pesticide A × the percentage (%) of pesticide A in the mixture + the toxicity index of pesticide B × the percentage (%) of pesticide B in the mixture

[0086]

[0087] 6 Experimental results

[0088] Table 1. Toxicity test results of thiamethoxam and deltamethrin mixtures against spinach aphids.

[0089]

[0090] Table 1 shows the toxicity test results of thiamethoxam and deltamethrin mixed in ratios of 49:5, 39:5, 29:5, and 5:5 against spinach aphids. As can be seen from Table 1, the toxicity (LC50) of the two agents mixed in different ratios against spinach aphid nymphs was 0.99, 0.81, 0.85, and 0.71 mg / L, respectively, with co-toxicity coefficients (CTC) of 124.96, 149.88, 138.72, and 127.38, respectively. The synergistic effect was most significant when the weight ratio of thiamethoxam to deltamethrin was 39:5.

[0091] Application Example 3: Field efficacy trials of pesticides for controlling spinach aphids (Examples 1-3)

[0092] 1. Experimental Objective

[0093] To verify the efficacy and safety of the 22% thiamethoxam·deltamethrin microcapsule suspension-suspension agent developed by the applicant against spinach aphids, to clarify the field application dosage and application technology, and to provide a scientific basis for pesticide registration.

[0094] 2. Test Basis

[0095] "Good Manufacturing Practice for Pesticide Registration Trials", "Agricultural Industry Standard of the People's Republic of China - Field Efficacy Test Guidelines for Pesticides - Control of Aphids in Cruciferous Vegetables with Insecticides (NY / T1464.27-2010)", and "Field Trial Operating Procedures for Aphids in Cruciferous Vegetables (NWP-SOP-I-012)".

[0096] 3 Experimental Locations

[0097] This experiment was conducted in Shaanxi and Shandong provinces.

[0098] 4. Selection of test subjects, crops and varieties

[0099] Experimental subject: Spinach aphid;

[0100] Experimental crop: spinach. The spinach seedlings were growing well at the time of the experiment.

[0101] 5. Experimental Design and Arrangement

[0102] 5.1 Dosage and Numbering of Pharmaceuticals

[0103] Table 2 Experimental Design of Test Reagents

[0104]

[0105] 5.2 Application time, investigation time and frequency.

[0106] Apply pesticide once during the initial peak period of spinach aphid infestation. Before applying pesticide, investigate the initial insect population. After applying pesticide, investigate the insect population at 1 day, 3 days, 7 days, and 10 days, for a total of 5 times.

[0107] 5.3 Usage Capacity

[0108] Use 40-50 liters of pesticide solution per mu (667 square meters), and 600-750 liters of pesticide solution per hectare.

[0109] 5.4 Method for Calculating Drug Efficacy

[0110]

[0111] 6 Experimental Results

[0112] Table 3. Field control efficacy of 22% thiamethoxam·deltamethrin microcapsule suspension against spinach aphids.

[0113]

[0114] Experimental results showed that when the tested pesticide was used to control spinach aphids, the control effects of the 22% thiamethoxam·deltamethrin microcapsule suspension-suspension agent, when sprayed once during the peak aphid infestation period, at a dosage of 19.8-26.4 g / ha of active ingredient, exhibited both rapid and sustained efficacy. The control efficacy was 75.73%–90.91% after 1 day; 82.59%–95.20% after 3 days; 89.75%–98.35% after 7 days; and 85.24%–89.70% after 10 days. It can be seen that in all experiments, the tested pesticide was significantly superior to the control agent in this group. Analysis of variance showed a highly significant difference between the 22% thiamethoxam·deltamethrin microcapsule suspension-suspension agent and the control agent. Throughout the entire experimental period, it had no significant impact on the color of spinach leaves or the growth status of the plants, and was safe for spinach with no phytotoxicity.

[0115] Application Example 4: Field efficacy trials of thiamethoxam·deltamethrin microcapsule suspension-suspension formulation for controlling spinach aphids (Examples 4-6)

[0116] The experimental objectives, experimental basis, experimental subjects, application time, survey time and number of surveys, water consumption, survey methods, and efficacy calculations are all the same as in Application Example 3.

[0117] 1. Experimental Location

[0118] This experiment was conducted in Hunan and Shandong provinces.

[0119] 2. Experimental Design and Arrangement

[0120] Table 4 Experimental Design of Test Reagents

[0121]

[0122] 3 Experimental Results

[0123] Table 5. Field control efficacy of thiamethoxam·deltamethrin microcapsule suspension against spinach aphids.

[0124]

[0125]

[0126] Experimental results showed that when the tested pesticides were used to control spinach aphids, the control effects of each treatment were as follows: The 11% thiamethoxam·deltamethrin microcapsule suspension-suspension, 33% thiamethoxam·deltamethrin microcapsule suspension-suspension, and 34% thiamethoxam·deltamethrin microcapsule suspension-suspension, when sprayed once during the peak aphid infestation period, at a dosage of 15.3-26.4 g / ha of active ingredient, exhibited both rapid and sustained efficacy. The control efficacy was 83.02%–91.06% after 1 day; 85.26%–93.54% after 3 days; 89.77%–96.90% after 7 days; and 88.18%–92.27% after 10 days. It can be seen that in each experiment, the tested pesticides were significantly superior to the control single agent in this group of experiments. According to the analysis of variance, the tested pesticides in Examples 4-6 showed highly significant differences compared to the control single agent. Throughout the entire experimental period, there was no significant impact on the color of spinach leaves or the growth status of the plants; the treatment was safe for spinach and caused no phytotoxicity. Application Example 5: (Examples 1-6) Environmental Impact Measurement Experiment

[0127] Our company commissioned a third-party company to conduct 10 tests on Examples 1-6, including acute oral toxicity tests on bees, acute contact toxicity tests on bees, acute oral toxicity tests on birds, acute toxicity tests on fish, acute toxicity tests on silkworms, acute activity inhibition tests on Daphnia, algal growth inhibition tests, acute toxicity tests on earthworms, acute toxicity tests on the natural enemy Trichogramma wasps, and acute contact toxicity tests on the natural enemy ladybugs. The test results are as follows:

[0128] 1) Acute oral toxicity test of honeybees showed that the toxicity level was low.

[0129] 2) Acute contact toxicity test on bees, the toxicity level was low.

[0130] 3) Acute oral toxicity test in birds showed a toxicity level of slightly toxic.

[0131] 4) Acute toxicity test on fish, the toxicity level is low.

[0132] 5) Acute toxicity test of silkworm, the toxicity level is low.

[0133] 6) The acute activity inhibition test of Daphnia showed that the toxicity level was low.

[0134] 7) Algal growth inhibition test, toxicity level is low toxicity.

[0135] 8) Acute toxicity test of earthworms, toxicity level is slightly toxic.

[0136] 9) Acute toxicity test of the natural enemy Trichogramma wasp: low risk.

[0137] 10) Acute contact toxicity test of ladybugs (natural enemy): low risk.

[0138] The above description, in conjunction with specific preferred embodiments, provides a further detailed explanation of the present invention. It should not be construed that the specific implementation of the present invention is limited to these descriptions. For those skilled in the art, various simple deductions or substitutions can be made without departing from the concept of the present invention, and all such modifications and substitutions should be considered within the scope of protection of the present invention.

Claims

1. A pesticidal composition, characterized by: The effective activities in the pesticide composition are thiamethoxam and deltamethrin, and the weight ratio of thiamethoxam to deltamethrin is 39:5 to 1:

1. The pesticide composition is in the form of a microcapsule suspension.

2. The pesticidal composition according to claim 1, characterized in that: The weight ratio of thiamethoxam to deltamethrin is 39:5 to 29:5, and optionally 39:

5.

3. The pesticidal composition according to claim 1 or 2, characterized in that: The total weight of thiamethoxam and deltamethrin in the composition is 5.5% to 44%, optionally 11% to 33%, and optionally 22%.

4. The pesticidal composition according to any one of claims 1 to 3, characterized in that: It also includes excipients, which optionally include one or more of the following: capsule wall material, dispersant, wetting agent, emulsifier, solvent, antifreeze, thickener, defoamer, pH adjuster, and preservative; Optionally, the capsule wall material is selected from one or more of isocyanates, organic amines, and polyols; Optionally, the dispersant is selected from one or more of the following: alkylnaphthalene formaldehyde condensate sulfonate, alkylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether sulfonate, phenethylphenol polyoxyethylene ether phosphate, alkyl polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene ether block copolymer, dispersant, dodecyl polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether phosphate, sodium naphthalene sulfonate formaldehyde condensate condensate block copolymer, comb-type polycarboxylate, sodium polycarboxylate, and lignin sulfonate; Optionally, the wetting agent is selected from one or more of the following: alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, phenethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate, alkyl naphthalene sulfonate, alkylphenol formaldehyde resin polyoxyethylene ether, triphenylethylphenol polyoxypropylene polyoxyethylene block polymer, sodium dodecyl sulfate, styrene-phenol formaldehyde resin propylene oxide block polyether, castor oil polyoxyethylene ether, fatty alcohol polyoxyethylene ether, alkyl glycoside, and sodium fatty alcohol polyoxyethylene ether sulfonate. Optionally, the emulsifier is selected from one or more of the following: calcium dodecylbenzenesulfonate, fatty alcohol polyoxyethylene ether, fatty alcohol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether, polyol fatty acid ester and its ethylene oxide adduct, and polyoxyethylene polyoxypropylene block copolymer. Optionally, the solvent is selected from one or more of cyclohexanone, 200# solvent oil, 150# solvent oil, vegetable oil, and xylene; Optionally, the antifreeze is selected from one or more of ethylene glycol, propylene glycol, glycerol, urea, polyethylene glycol, and sorbitol; Optionally, the preservative is sodium benzoate; Optionally, the defoamer is a silicone defoamer, a C10-20 saturated fatty acid compound, a C8-10 fatty alcohol, hexanol, butanol, or octanol; Optionally, the pH adjuster is selected from one or more of glacial acetic acid and citric acid; Optionally, the thickener is selected from one or more of xanthan gum, magnesium aluminum silicate, silica, and polyvinyl alcohol.

5. The pesticidal composition according to claim 4, characterized in that: The capsule wall material accounts for 0.1% to 5% of the pesticide composition by weight, optionally 0.5% to 3%; Optionally, the dispersant accounts for 1% to 10% by weight of the pesticide composition, and optionally 2% to 7%; Optionally, the wetting agent accounts for 0.5% to 5% by weight of the pesticide composition, and optionally 0.5% to 3%; Optionally, the emulsifier accounts for 0.5% to 8% by weight of the pesticide composition, or alternatively 0.5% to 3%, or alternatively 0.8% to 1.5%. Optionally, the antifreeze accounts for 1% to 6% by weight of the pesticide composition, and optionally 3% to 5%; Optionally, the solvent accounts for 3% to 45% of the pesticide composition by weight, optionally 10% to 30%, and optionally 15% to 25%. Optionally, the thickener accounts for 0.05% to 2% by weight of the pesticide composition, and optionally 0.1% to 1%. Optionally, the pH adjuster accounts for 0-1.5% of the pesticide composition by weight, and optionally 0-1% pH. Optionally, the preservative accounts for 0-1% of the pesticide composition by weight, and optionally 0.1%-0.8%; Optionally, the defoamer accounts for 0-1% of the pesticide composition by weight, and optionally 0-0.5%; Optionally, the water content of the pesticide composition is 30% to 70% by weight, optionally 35% to 60%, and optionally 40% to 50%.

6. Use of a pesticidal composition according to any one of claims 1 to 5 for the control of pests of crops, characterized in that: The pests mentioned include thrips, aphids, leafhoppers, whiteflies, and planthoppers, with spinach aphids being an optional example.

7. Use according to claim 6, characterized in that: The pesticide composition is used to control spinach aphids. The effective active ingredient dosage is 12-35 g / ha, the optional dosage is 15.3-26.4 g / ha, and the optional dosage is 19.8-26.4 g / ha.

Images