Natural product composition for assisting in maintaining blood fat health level and application of natural product composition

Abstract

The invention relates to the technical field of health-care food, in particular to a natural product composition assisting in maintaining the health level of blood fat and application of the natural product composition. The natural product composition consists of an American ginseng extract, a pseudo-ginseng extract and red yeast rice. After the American ginseng extract, the pseudo-ginseng extract and the red yeast rice are combined for use, the composition has a synergistic effect and has the effect of assisting in maintaining the health level of blood fat.

Description

Technical Field

[0001] This invention relates to the field of health food technology, and in particular to a natural product composition that helps maintain healthy blood lipid levels and its application. Background Technology

[0002] With the improvement of people's living standards and changes in dietary habits, the incidence of sub-health conditions such as abnormal blood sugar, abnormal blood lipids, and hypertension is rapidly increasing. Among these, abnormal blood lipids are characterized by significantly elevated levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) compared to normal individuals, while high-density lipoprotein cholesterol (HDL-C) is significantly lower. Abnormal blood lipids are an early symptom of lipid metabolism dysfunction, and their main harm to the human body is damage to the cardiovascular system, making them a major cause of heart disease, coronary heart disease, and arteriosclerosis. Early intervention for abnormal blood lipids can effectively prevent the occurrence of related diseases. Currently, the main chemical drugs for lowering blood lipids fall into four categories: statins, fibrates, hydrochlorides, and bile acid sequestrants. These drugs are highly effective in controlling blood lipids, but they all have varying degrees of toxic side effects. For example, statins may cause skeletal muscle degradation, resulting in pain and other side effects. Therefore, it is necessary to explore new adjuvant treatment methods.

[0003] Traditional Chinese medicine (TCM) believes that the terms "gao" and "zhi" in TCM classics are similar to blood lipids, originating from food and water and transformed by the spleen and stomach. The formation, transport, and distribution of blood lipids all depend on the physiological functions of the spleen. When the spleen is weak and qi is deficient, its ability to transform and transport qi is impaired. Food and water cannot be transformed into qi, blood, and essence to nourish the body; instead, water is transformed into phlegm, which becomes a pathogenic factor and a cause of hyperlipidemia. "Qi is the commander of blood," and "Qi is what moves blood." When qi is abundant, blood flows smoothly and swiftly; when qi is deficient, blood flow is slow and sluggish, potentially leading to blood stasis. Blood stasis can cause or worsen hyperlipidemia. When the spleen fails to function properly, qi circulation is obstructed, affecting the blood. Weak qi cannot propel blood circulation, leading to stagnation, phlegm production, and blood stasis. Treatment should focus on tonifying qi and strengthening the spleen, promoting blood circulation, and removing blood stasis to restore the spleen's function of transforming qi, blood, and essence. With qi circulating smoothly, blood stasis will dissipate and lipids will clear. Based on the above background, developing a health food product that helps maintain healthy blood lipid levels, according to traditional Chinese medicine theory and combined with modern medical technology, is of great significance and has market demand. Summary of the Invention

[0004] One of the objectives of this invention is to provide a natural product composition formulation that helps maintain healthy blood lipid levels, thereby addressing the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution.

[0006] This invention provides a natural product composition formula that helps maintain healthy blood lipid levels, comprising the following active ingredient concentrations and weight parts of raw materials: by weight, the amount of each raw material in the natural product composition is as follows: 10-20 parts of American ginseng extract with a total saponin content of 20%-25%, 20-40 parts of Panax notoginseng extract with a total saponin content of 25%-30%, and 45-655 parts of red yeast rice with a lovastatin content of 1%.

[0007] The natural product composition formulation provided by this invention has the following effects on each component:

[0008] American ginseng: American ginseng is a perennial herb of the Araliaceae family. It was first recorded in "Ben Cao Cong Xin" and is a precious medicinal material. It originated in the United States and Canada. The medicinal part is its dried rhizome. It is cool in nature and sweet and slightly bitter in taste. It has the functions of replenishing qi and nourishing yin, clearing heat and promoting body fluid. It is often used to treat diabetes, cough with phlegm and blood due to yin deficiency and fire excess, and fatigue and thirst due to heat-related diseases that damage both body fluid and qi. Modern research results show that the total saponin active ingredients contained in American ginseng can significantly reduce blood glucose and lipid-related indicators such as glucose, total triglycerides, and total cholesterol in serum, promote the utilization of glucose by adipocytes, and inhibit the lipolysis effect of TNF-α, thereby regulating glucose and lipid metabolism.

[0009] Panax notoginseng: Panax notoginseng is a perennial herb of the Araliaceae family, mainly produced in Yunnan, Guangxi, and Sichuan provinces. It is a commonly used traditional Chinese medicine in clinical practice. Panax notoginseng has a sweet and slightly bitter taste, and is warm in nature. It enters the heart, liver, stomach, and small intestine meridians, and has the effects of stopping bleeding, relieving pain, reducing swelling, dispelling fatigue, tonifying deficiency, and strengthening the body. It is mainly used to treat hemoptysis, maggot-induced bleeding, traumatic bleeding, and swelling and pain from falls and injuries. Modern research has confirmed that the main active ingredient in Panax notoginseng, total saponins, has various biological activities, among which its effect on regulating glucose and lipid metabolism is significant, and it has functions such as lowering blood sugar, promoting the regeneration of pancreatic β cells, and improving the body's metabolism.

[0010] Red yeast rice: Red yeast rice is produced by the growth and reproduction of Monascus purpureus parasitizing rice and brown rice. It has been used for over a thousand years to improve the flavor and texture of food. Due to its rich medicinal value, it has also been used in traditional Chinese medicine for a long time, primarily to treat indigestion, promote blood circulation, strengthen the spleen and stomach, treat dysentery, women's blood stasis pain, and postpartum lochia. Modern research has discovered lovastatin (monacolin K) in red yeast rice. Experimental and clinical practice have confirmed that lovastatin has a good effect on lowering serum cholesterol, and statin derivatives derived from it are widely used in the clinical treatment of hyperlipidemia and other conditions.

[0011] This invention demonstrates that the combination of American ginseng extract, Panax notoginseng extract, and red yeast rice produces a synergistic effect, which helps maintain healthy blood lipid levels, especially under specific ratio conditions, where the synergistic effect is significant.

[0012] Further, the composition comprises 12-15 parts of American ginseng extract with a total saponin content of 20%-25%, 30-35 parts of Panax notoginseng extract with a total saponin content of 25%-30%, and 50-58 parts of red yeast rice with a lovastatin content of 1%. More preferably, the composition comprises 15 parts of American ginseng extract with a total saponin content of 20%-25%, 35 parts of Panax notoginseng extract with a total saponin content of 25%-30%, and 50 parts of red yeast rice with a lovastatin content of 1%.

[0013] The present invention further provides a health food product comprising the aforementioned natural product composition and food-grade excipients. Specifically, the dosage form of the health food product is a tablet, capsule, powder, granule, pill, or oral liquid.

[0014] More specifically, the dosage form of the health food is powder, and the excipients that are acceptable in food science are one or more of plasticizers, flavorings, and sweeteners.

[0015] The present invention also provides the use of the natural product composition in the preparation of health foods that help maintain healthy blood lipid levels.

[0016] Specifically, it is used to help lower blood lipids, or to reduce fat accumulation caused by a high-fat diet. Detailed Implementation

[0017] The present invention will now be described through specific embodiments in order to better improve the present invention, but these embodiments do not constitute a limitation thereof.

[0018] Example 1

[0019] American ginseng extract powder with a total saponin content of 20% to 25% (trade name: American ginseng extract; purchased from Jilin Hongjiu Biotechnology Co., Ltd.; batch number 220102).

[0020] The recommended daily intake is 0.3g.

[0021] Example 2

[0022] Use Panax notoginseng extract powder with a total saponin content of 25% to 30% (trade name: Panax notoginseng extract; purchased from Tianxingjian Biochemical Technology Co., Ltd.).

[0023] The recommended daily intake is 0.7g.

[0024] Example 3

[0025] Red yeast rice powder with a lovastatin content of 1% (trade name: red yeast rice powder; purchased from Wuhan Jiacheng Biological Products Co., Ltd.; batch number 220409).

[0026] The recommended daily intake is 1g.

[0027] Example 4

[0028] Different natural products are formulated into powder according to the following proportions: 15% American ginseng extract with a total saponin content of 20%–25%, 35% Panax notoginseng extract with a total saponin content of 25%–30%, and 50% red yeast rice with a lovastatin content of 1%. The raw materials, i.e., the extract powder, are directly mixed to obtain the powder.

[0029] The recommended daily intake is 2g.

[0030] Example 5

[0031] Different natural products are formulated into powder according to the following proportions: 12% American ginseng extract with a total saponin content of 20%–25%, 30% Panax notoginseng extract with a total saponin content of 25%–30%, and 58% red yeast rice with a lovastatin content of 1%. The raw materials, i.e., the extract powder, are directly mixed to obtain the powder.

[0032] The recommended daily intake is 1.7g.

[0033] Example 6

[0034] Different natural products are formulated into powder according to the following proportions: 15% American ginseng extract with a total saponin content of 20%–25%, 35% Panax notoginseng extract with a total saponin content of 25%–30%, and 50% red yeast rice with a lovastatin content of 1%. The raw materials, i.e., the extract powder, are directly mixed to obtain the powder.

[0035] The recommended daily intake is 1g.

[0036] Examples 1-6 show the animal experiments demonstrating the lipid-lowering function of the natural product compositions.

[0037] Experimental Materials: The natural product composition described in Example 1: Based on the recommended daily human dose of 0.3g, the equivalent dose in rats, calculated using the human-to-rat body surface area ratio, was 0.025g / (kg·d); the natural product composition described in Example 2: Based on the recommended daily human dose of 0.7g, the equivalent dose in rats, calculated using the human-to-rat body surface area ratio, was 0.062g / (kg·d); the natural product composition described in Example 3: Based on the recommended daily human dose of 1g, the equivalent dose in rats, calculated using the human-to-rat body surface area ratio, was 0.083g / (kg·d); the natural product composition described in Example 4: Based on the recommended daily human dose of 2g, the equivalent dose in rats, calculated using the human-to-rat body surface area ratio, was 0.025g / (kg·d). The equivalent dose for rats, calculated based on the surface area, is 0.169 g / (kg·d) of the natural product composition. The natural product composition in Example 5, based on the recommended daily intake of 1.7 g for humans, yields an equivalent dose of 0.141 g / (kg·d) for rats, calculated from the human-rat body surface area. The natural product composition in Example 6, based on the recommended daily intake of 1 g for humans, yields an equivalent dose of 0.083 g / (kg·d) for rats, calculated from the human-rat body surface area. The model animals were fed a maintenance diet supplemented with 20.0% sucrose, 15.0% lard, 1.2% cholesterol, 0.2% sodium cholate, and appropriate amounts of casein, dicalcium phosphate, and limestone.

[0038] Establishment of a mixed hyperlipidemia animal model: Ninety-six male SD rats were acclimatized for 7 days under experimental conditions and then randomly divided into two groups according to body weight. Twelve rats were fed a maintenance diet as the blank control group, and 84 rats were given a model diet as the model group. Body weight was measured weekly. After 1-2 weeks of model diet administration, blood was collected from both the blank control and model groups without fasting to measure serum TC (total cholesterol), TG (triglycerides), LDL-C (low-density lipoprotein), and HDL-C (high-density lipoprotein). Based on TC levels, the model group rats were randomly divided into seven groups (i.e., model control group, Example 1 group, Example 2 group, Example 3 group, Example 4 group, Example 5 group, and Example 6 group). There were no significant differences in TC, TG, LDL-C, and HDL-C among the rats in each group after grouping. Compared with the blank control group, the model groups showed significant increases in TC, TG, and LDL-C, thus confirming the successful establishment of the model.

[0039] Experimental Procedure: After the model was established, each example group was administered the natural product composition orally daily at the corresponding dose for 4 consecutive weeks. The blank control group and the model control group were simultaneously given the same volume of the corresponding solvent. The blank control group continued to be given a maintenance diet, while the model control group and each example group continued to be given the model diet. After the last administration of the natural product composition, rats in each group were fasted but allowed free water, and blood was collected. Serum was separated as soon as possible after blood collection, and the serum TC, TG, LDL-C, and HDL-C levels were measured. According to the "Draft for Comments on the Functional Testing and Evaluation Methods of Health Foods (2022 Edition)," compared with the model control group, the TC, TG, and LDL-C levels in the natural product composition group were significantly lower. At the same time, the serum high-density lipoprotein cholesterol in the natural product composition group was not significantly lower than that in the model control group. It can be determined that the natural product composition helps maintain healthy blood lipid levels. The functional animal experiment results were positive. After blood collection, the rats were sacrificed, and the mesenteric adipose tissue was collected and the weight of the mesenteric adipose tissue was measured.

[0040] Experimental Results: Serum TC, TG, and LDL-C levels in the model control group were significantly higher than those in the blank group (p < 0.05), indicating that the model was established. After continuous administration of the natural product composition for 4 weeks, serum TC, TG, and LDL-C levels in Example 2, Example 3, Example 5, and Example 6 groups were significantly lower than those in the model control group (p < 0.05), while serum HDL-C levels showed no significant difference from the blank group. The results of the functional animal experiment indicated that the natural product composition helps maintain healthy blood lipid levels. At the same time, the mesenteric fat weight in the compound group (Example 6 group) was also significantly lower than that in the model control group and other example groups (p < 0.05), indicating that the combination of the three extracts was more effective in reducing fat accumulation caused by a high-fat diet than the use of the extracts alone.

[0041] The specific data is as follows:

[0042]

[0043] Animal experiments showed that Examples 1 and 4 were not very effective, especially Example 4, indicating that a certain compound ratio is required to achieve a synergistic effect.

Claims

1. A natural product composition that helps maintain healthy blood lipid levels, characterized in that, The amounts of each raw material in the natural product composition by weight are as follows: 10-20 parts of American ginseng extract with a total saponin content of 20%-25%, 20-40 parts of Panax notoginseng extract with a total saponin content of 25%-30%, and 45-655 parts of red yeast rice with a lovastatin content of 1%.

2. The composition according to claim 1, characterized in that, 12-15 parts of American ginseng extract with a total saponin content of 20%-25%, 30-35 parts of Panax notoginseng extract with a total saponin content of 25%-30%, and 50-58 parts of red yeast rice with a lovastatin content of 1%.

3. The composition according to claim 1, characterized in that, 15 portions of American ginseng extract with a total saponin content of 20%~25%, 35 portions of Panax notoginseng extract with a total saponin content of 25%~30%, and 50 portions of red yeast rice with a lovastatin content of 1%.

4. A health food product, characterized in that, It includes the natural product composition of claim 1, 2 or 3 and food-grade excipients.

5. The health food according to claim 4, characterized in that, The dosage form of the health food is tablets, capsules, powders, granules, pills, or oral liquids.

6. The health food according to claim 4 or 5, characterized in that, The dosage form of the health food is powder, and the excipients that are acceptable in food science are one or more of the following: plasticizers, flavorings, and sweeteners.

7. The use of the natural product composition according to claim 1, 2 or 3 in the preparation of health foods that help maintain healthy blood lipid levels.

8. The application as described in claim 7, characterized in that, Its use is to help lower blood lipids.

9. The application as described in claim 8, characterized in that, It is used to reduce fat accumulation caused by a high-fat diet.

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