Body-weight-reducing Wuming cream and preparation method thereof

Abstract

The invention discloses a body-weight-losing Wuming paste and a preparation method thereof. The body-weight-losing Wuming paste comprises the following components in parts by mass: 1.5 to 2.5 parts of lotus leaves, 1.0 to 1.5 parts of dried orange peel, 1.0 to 1.5 parts of mulberry leaves, 1.0 to 1.5 parts of chrysanthemum, 1.0 to 1.5 parts of lalang grass rhizome, 1.5 to 2.5 parts of astragalus membranaceus, 2.0 to 2.6 parts of fried malt, 10.0 to 15.0 parts of fried hawthorn, 16.0 to 22.0 parts of fried coix seeds, 10.0 to 15.0 parts of phaseolus calcaratus and 48.0 to 58.0 parts of mulberry clear paste. The preparation method comprises the following steps: chemical grouping of raw materials, directional extraction and treatment, collaborative inclusion and concentration, bistable colloid construction and paste collection, and filling and sterilization. According to the invention, the raw materials are scientifically grouped according to chemical properties, a differential extraction process is adopted, and a colloid mill micro-nano homogenization technology and a supramolecular inclusion technology are combined, so that the technical problems that the traditional cream is easy to layer and the retention rate of effective components is low are solved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine compound preparation technology, and in particular to a Qing Shen Wu Ming ointment and its preparation method. Background Technology

[0002] Traditional Chinese medicine pastes, as an important material carrier of the TCM concept of "preventive treatment," have advantages such as long-lasting efficacy, convenient administration, and pleasant taste, and have been widely used in the fields of health foods and functional foods in recent years. The traditional preparation of pastes often adopts a "one-pot boiling" water extraction and alcohol precipitation process, in which all the medicinal materials are mixed, boiled with water 2-3 times, the filtrates are combined, concentrated, and excipients are added to form a paste.

[0003] In existing technologies, some improved processes have introduced techniques such as ultrasonic extraction and simple colloid milling, but the following technical defects still exist:

[0004] 1. Homogenization of component extraction: The chemical properties of different medicinal materials in compound prescriptions vary significantly. For example, lotus leaf and tangerine peel are rich in volatile oils (D-limonene, camphor, etc.), astragalus and imperata root are rich in polysaccharides, while hawthorn and coix seed are rich in fat-soluble triterpenoids and a large amount of insoluble dietary fiber. Traditional uniform decoction process results in a loss rate of >60% of volatile components, while the extraction rate of polysaccharides is <40% due to cell wall barriers, and fat-soluble components are difficult to dissolve due to being wrapped by fiber.

[0005] 2. Insufficient stability of the paste: Pastes containing a lot of dietary fiber are prone to solid-liquid separation and fiber precipitation (commonly known as "returning sand") during storage, which seriously affects product quality and consumer compliance;

[0006] 3. Low bioavailability: Traditional processes do not fully break down plant cell walls, and large-molecule dietary fiber encapsulates fat-soluble functional ingredients, resulting in insufficient intestinal absorption.

[0007] Therefore, there is an urgent need to develop a new technology for preparing traditional Chinese medicine pastes that can retain effective components with different properties to the maximum extent, form a thermodynamically stable colloidal system, and improve bioavailability, so as to meet the needs of large-scale industrial production and long-term storage and transportation. Summary of the Invention

[0008] The purpose of this invention is to provide a lightweight five-brightness paste and its preparation method. This invention solves the technical problems of traditional paste formulas, such as easy layering and low retention rate of effective ingredients, by scientifically grouping raw materials according to their chemical properties, employing differentiated extraction processes, and combining colloid mill micro-nano homogenization technology and supramolecular inclusion technology.

[0009] The technical solution of this invention:

[0010] A type of slimming five-ingredient ointment, by weight ratio, includes 1.5-2.5 parts lotus leaf, 1.0-1.5 parts dried tangerine peel, 1.0-1.5 parts mulberry leaf, 1.0-1.5 parts chrysanthemum, 1.0-1.5 parts Imperata cylindrica root, 1.5-2.5 parts Astragalus membranaceus, 2.0-2.6 parts roasted malt, 10.0-15.0 parts roasted hawthorn, 16.0-22.0 parts roasted coix seed, 10.0-15.0 parts red adzuki bean, and 48.0-58.0 parts mulberry extract.

[0011] The aforementioned Five Brightening Paste contains, by weight ratio, 2.04 parts lotus leaf, 1.22 parts dried tangerine peel, 1.22 parts mulberry leaf, 1.22 parts chrysanthemum, 1.22 parts Imperata cylindrica root, 2.04 parts astragalus, 2.30 parts roasted malt, 12.69 parts roasted hawthorn, 19.04 parts roasted coix seed, 12.69 parts red adzuki bean, and 53.76 parts mulberry extract.

[0012] A method for preparing a light-body five-brightness ointment, characterized by comprising the following steps:

[0013] S1. Raw material chemical grouping: The raw materials are grouped according to their chemical properties and physical characteristics, including Group A of volatile flavonoids, Group B of polysaccharides, and Group C of fat-soluble dietary fiber.

[0014] S2. Targeted Extraction and Processing:

[0015] Groups A, B, and C were extracted and processed separately to obtain extracts from Group A, volatile oil fractions, extracts from Group B, and micro / nano mud-like substances from Group C.

[0016] S3. Synergistic Inclusion and Concentration: The extracts from group A and group B were combined and concentrated under reduced pressure at a vacuum of -0.08 to -0.09 MPa and a temperature of 60-70℃. The relative density of the sample was measured at 85℃ to be 1.13-1.14, yielding a concentrated herbal extract. The volatile oil fraction was then encapsulated with β-cyclodextrin and mixed into the concentrated herbal extract.

[0017] S4. Construction and collection of bistable colloid: Mix the concentrated herbal extract and mulberry extract at a weight ratio of 1000:7323, and add the micro-nano mud-like material of group C. Adjust the zeta potential of the system to -25mV to -35mV while stirring. The potential is controlled by adding 0.1-0.3% lecithin and / or adjusting the pH to 4.5-5.5. Heat and cook until the relative density is 1.20-1.21 and the moisture content is 50-55% at 20℃ to obtain a semi-finished paste.

[0018] S5. Filling and Sterilization: Fill the semi-finished ointment at 30-40℃, seal it, and sterilize it at 105℃ for 25 minutes to obtain the finished product, Qing Shen Wu Ming Ointment.

[0019] In the aforementioned method for preparing the Light Body Five Brightness Ointment, the specific details of the chemical grouping of the raw materials mentioned in step S1 are as follows:

[0020] Group A of volatile flavonoids includes lotus leaf, dried tangerine peel, mulberry leaf and chrysanthemum, which are rich in volatile oils and heat-sensitive flavonoid glycosides;

[0021] Group B of polysaccharides includes Imperata cylindrica root, Astragalus membranaceus, and roasted malt, which are rich in polysaccharides and saponins.

[0022] Group C of fat-soluble dietary fiber includes seedless roasted hawthorn, roasted Job's tears, and red beans, which are rich in fat-soluble active ingredients and insoluble dietary fiber;

[0023] The ratio of total weight of group A to total weight of group B to total weight of group C is 1:0.8-1.0:6.5-7.5, with roasted coix seed accounting for 40-50% of the total weight of group C. This ratio allows the volatile flavonoids, polysaccharides, and fat-soluble dietary fiber to form a specific three-phase distribution in the final paste. The micro-nano fibers of group C serve as a continuous phase framework, and the active ingredients of groups A and B are adsorbed on the surface of the framework, thus improving the stability of the system.

[0024] In the aforementioned method for preparing the Five Brightness Elixir for Lightening the Body, the directional extraction and processing described in step S2 are as follows:

[0025] S2.1 Extraction of Group A: Mix the raw materials of Group A, add 8-10 times the amount of water, and soak at 40-50℃ for 30 minutes; first, perform steam distillation extraction for 1.5 hours, collect the volatile oil fraction, and then decoct the residue twice, adding 6-8 times the amount of water each time, and decoct for 2 hours each time. Combine the filtrates to obtain the extract of Group A.

[0026] S2.2 Extraction of Group B: Mix the raw materials of Group B, add 10-12 times the amount of water, add 0.3% of the weight of the raw materials of the compound enzyme preparation, enzymatically hydrolyze at 45℃ for 1 hour, then ultrasonically extract for 30 minutes at 300W power and 40kHz frequency, then heat to 95℃ to inactivate the enzyme and decoct for 1.5 hours, and filter to obtain the extract of Group B; the compound enzyme preparation is cellulase: pectinase = 2:1, w / w;

[0027] S2.3, Group C micro-nano processing: The Group C raw materials were placed in a medicinal cloth bag, placed in an extraction tank with twice the amount of water, and pressure-cooked for 1.5 hours at 0.10-0.15 MPa. After removal, they were mixed with a portion of mulberry extract and subjected to three-stage gradient micro-nano homogenization through a colloid mill. The first stage gap was 40±5 μm, the second stage gap was 30±3 μm, and the third stage gap was 20±2 μm. The particle size D50 was controlled to be 15-35 μm to obtain Group C micro-nano mud.

[0028] In the aforementioned method for preparing the Five Brightness Ointment, during the extraction of Group A in step S2.1, the steam flow rate of the steam distillation is 150-200 mL / min, and the collected volatile oil is encapsulated with 8-10 times the amount of β-cyclodextrin at 40°C for 2 hours.

[0029] In the aforementioned method for preparing the Five Brightness Ointment, in the extraction of Group B in step S2.2, the activity of cellulase in the compound enzyme preparation is ≥10000u / g, the activity of pectinase is ≥30000u / g, and the pH of enzymatic hydrolysis is controlled at 4.5-5.0.

[0030] In the aforementioned method for preparing the Qing Shen Wu Ming Ointment, in the micro-nano processing of group C described in step S2.3, the medicinal cloth bag is made of 400-mesh nylon material with a pore size of 38μm; the colloid mill speed is 3000rpm, and each stage is cycled once.

[0031] In the aforementioned method for preparing the Light Body Five Brightness Ointment, the three-stage gradient micro-nano homogenization process involves a first-stage gap of 40±5μm that matches the initial particle size of the C group raw materials after high-pressure cooking (50-80μm), achieving pre-crushing; a second-stage gap of 30±3μm that matches the thickness of the fiber cell wall (20-35μm), achieving cell wall crushing; and a third-stage gap of 20±2μm that matches the target particle size D50 = 15-35μm, achieving finishing.

[0032] The ratio of the three interstitial gaps is approximately 4:3:2, which corresponds to the crystalline region-amorphous region-microfibril structure hierarchy of cellulose.

[0033] In the aforementioned method for preparing the Qing Shen Wu Ming Ointment, the Zeta potential control range in step S4 is -30mV to -32mV.

[0034] In the aforementioned method for preparing the Five Brightness Ointment, during the bistable colloid construction process described in step S4, Astragalus polysaccharide and mulberry anthocyanin form primary aggregates through hydrogen bonds. These primary aggregates adsorb onto the surface of group C micro / nanofibers, forming a "core-shell" structure. Lecithin molecules insert into the interface between the primary aggregates and the fibers, reducing interfacial tension. Simultaneously, under pH 4.5-5.5 conditions, the phenolic hydroxyl groups of anthocyanins partially dissociate, forming electrostatic repulsion with the carboxyl groups on the fiber surface, resulting in a Zeta potential of -30mV. The electrostatic repulsion and steric hindrance work synergistically to maintain a TSI < 0.5 in the ointment for 18 months.

[0035] In the aforementioned method for preparing the Five Brightness Essence Paste, the mulberry extract in step S4 is prepared by low-temperature vacuum concentration, with a temperature not exceeding 60°C, a vacuum degree of -0.085MPa or higher, and an anthocyanin retention rate of ≥85%.

[0036] Compared with the prior art, the beneficial effects of this application are as follows:

[0037] 1. Adopting a chemical grouping-targeted extraction strategy: Breaking through the traditional "one-pot cooking" mindset, the medicinal materials are scientifically grouped based on their chemical properties, and differentiated processes such as steam distillation, ultrasonic-enzymatic hydrolysis synergy, and high-pressure cooking-micro-nano homogenization are used to significantly improve the retention rate of volatile oil, total flavonoids, and astragalus polysaccharide extraction rate, which are significantly improved compared to traditional processes.

[0038] 2. Constructing a bistable colloidal system: Zeta potential regulation (-25mV to -35mV) was introduced into the preparation of traditional Chinese medicine pastes. By combining the dual mechanisms of electrostatic stability and steric hindrance, the paste can maintain TSI<0.5 during the long shelf life, thus solving the problem of "returning sand" in fibrous pastes.

[0039] 3. Significantly improve bioavailability: Micro-nano processing increases the specific surface area of ​​fat-soluble components and improves water solubility through surface modification. The relative bioavailability of lotus leaf alkaloids and astragaloside A is improved.

[0040] 4. Suitable for large-scale industrial production: It has clearly defined process parameters, can be implemented using conventional extraction tanks and colloid mill equipment, and has a lower overall cost than traditional processes, resulting in significant economic benefits. Attached Figure Description

[0041] Figure 1 This is a flowchart of the preparation method of the Light Body Five Brightness Ointment of the present invention. Detailed Implementation

[0042] The present invention will be further described below with reference to the accompanying drawings and embodiments, but this should not be construed as limiting the present invention.

[0043] Example 1. Preparation using standard process

[0044] A method for preparing a slimming five-brightness ointment, based on the production of 1000 bottles (160g / bottle), includes the following steps:

[0045] S1, Chemical Grouping of Raw Materials:

[0046] Group A includes 2.04 kg of lotus leaves, 1.22 kg of dried tangerine peel, 1.22 kg of mulberry leaves, and 1.22 kg of chrysanthemum, totaling 6.70 kg;

[0047] Group B includes 1.22 kg of Imperata cylindrica root, 2.04 kg of Astragalus membranaceus, and 2.30 kg of roasted malt, totaling 5.56 kg;

[0048] Group C includes 12.69 kg of roasted hawthorn (seedless), 19.04 kg of roasted Job's tears, and 12.69 kg of red beans, totaling 44.42 kg;

[0049] 53.76 kg of mulberry extract;

[0050] S2. Targeted Extraction and Processing:

[0051] S2.1, Extraction of Group A: The raw materials were mixed, 60 kg of purified water was added, and the mixture was soaked at 45℃ for 30 min; steam distillation was performed for 1.5 h at a steam flow rate of 180 mL / min, and 182 mL of volatile oil was collected; the residue was decocted in two juices (48 kg of water for the first juice and 48 kg of water for the second juice), and the filtrates were combined and concentrated to a relative density of 1.09 (60℃) to obtain 8.3 kg of Group A extract;

[0052] S2.2, Extraction of Group B: Mix the raw materials, add 60kg of water, add 28g of compound enzyme (18.7g of cellulase and 9.3g of pectinase), adjust the pH to 4.8, enzymatically hydrolyze at 45℃ for 1h; sonicate (300W, 40kHz) for 30min; inactivate the enzyme at 95℃ for 10min, then decoct for 1.5h; filter, concentrate to a relative density of 1.08 (60℃), and obtain 7.6kg of Group B extract;

[0053] S2.3, Group C Micro-nano Processing: The raw materials were placed in a 400-mesh nylon bag, 88 kg of water was added, and the mixture was steamed at 0.12 MPa for 1.5 h. After removal, it was mixed with 5 kg of mulberry extract and ground in three stages using a colloid mill (with gaps of 40 μm, 30 μm, and 20 μm respectively, at a speed of 3000 rpm, once per stage) to obtain 43 kg of micro-nano mud-like material. The laser particle size analyzer measured D50=28 μm and D90=58 μm.

[0054] S3, Co-inclusion and Concentration:

[0055] S3.1 The volatile oil was encapsulated with 1.48 kg of β-cyclodextrin (40℃, stirring for 2 h), with an encapsulation rate of 87%.

[0056] S3.2, the extracts of group A, group B, and volatile oil inclusion complex were combined and concentrated under reduced pressure (-0.085MPa, 65℃) to a relative density of 1.135 (85℃) to obtain 15.1kg of concentrated medicinal extract;

[0057] S4. Construction and collection of bistable colloids:

[0058] S4.1. Mix the concentrated medicinal herb extract (15.1 kg) with the remaining mulberry extract (48.76 kg) and the micro-nano mud-like material from group C (43 kg);

[0059] S4.2 Add 0.15 kg of food-grade lecithin, and adjust the pH to 5.0 with a citric acid-sodium citrate buffer while stirring;

[0060] S4.3 The zeta potential measured using Zetasizer Nano ZS is -30mV, which is within the range of -25mV to -35mV;

[0061] S4.4 Continue cooking until the relative density is 1.205 (20℃), the moisture content is 51.8%, and the viscosity at 28℃ is 9850 mPa·s;

[0062] S5. Filling and sterilization:

[0063] Fill 160mL glass bottles at 37℃, seal, and sterilize at 105℃ for 25 minutes to obtain the finished product.

[0064] Example 2. High-stability process (optimized zeta potential)

[0065] A method for preparing a light-body five-brightness ointment is basically the same as in Example 1, except that in step S4:

[0066] Add 0.25% lecithin and 0.1% xanthan gum (for synergistic thickening), adjust the pH to 4.8, and control the zeta potential at -32mV.

[0067] The resulting paste had a dynamic stability index (TSI) of 0.35 (after 6 months of storage at 25°C), which is a further optimization compared to 0.42 in Example 1.

[0068] Example 3. High extraction rate process (enhanced enzymatic hydrolysis)

[0069] A method for preparing a light-body five-brightness ointment is basically the same as in Example 1, except that in step S2:

[0070] The enzymatic hydrolysis time was extended to 1.5 h, and the sonication time was extended to 45 min;

[0071] Group A steam distillation was performed under reduced pressure (-0.06 MPa, 85 °C).

[0072] In the prepared product, the extraction rate of Astragalus polysaccharides increased to 82.3%, and the collection rate of volatile oil increased to 91%.

[0073] Comparative Example 1: Traditional water extraction process

[0074] Mix all raw materials (groups A, B, and C, totaling 56.68 kg), add 10 times the amount of water (566.8 kg), decoct twice (2 hours each time at 100°C), combine the filtrates and concentrate, add 53.76 kg of mulberry extract and mix well, reduce the extract to a relative density of 1.20 (20°C).

[0075] The difference lies in the fact that there is no grouping extraction, no micro-nano processing, and no potential control.

[0076] Comparative Example 2: Simple colloid milling treatment (no chemical grouping)

[0077] After all the raw materials are boiled and extracted together, they are then processed once more through a colloid mill (50μm gap).

[0078] The difference lies in the absence of pre-softening and grading.

[0079] Verification Experiment

[0080] Experiment 1: Accelerated Stability Test

[0081] Method: The samples were placed in a constant temperature and humidity chamber (40℃±2℃, RH75%±5%), and TSI was measured using Turbiscan Lab at 0, 1, 2, 3, and 6 months.

[0082] The results are shown in the table below:

[0083] Table 1 Stability Test Table

[0084] sample October TSI March TSI June TSI Appearance observation Example 1 0.15 0.28 0.42 Uniform, without stratification Example 2 0.12 0.22 0.35 Uniform, without stratification Comparative Example 1 0.45 1.85 3.20 3 months of clear stratification Comparative Example 2 0.38 1.12 2.05 3 months of slight stratification

[0085] As shown in the table above, the product prepared by the method of this application has a much higher stability than that prepared by traditional processes.

[0086] The preparation method of this invention can be rapidly implemented in existing traditional Chinese medicine extraction production lines, requiring only the addition of a colloid mill and online Zeta potential monitoring equipment, resulting in low equipment modification costs. At the scale of mass industrial production, the overall cost is lower than traditional processes, and product stability is significantly improved, making it suitable for large-scale industrial production.

Claims

1. A light-body five-brightness ointment, characterized in that: The ingredients, in the following proportions by weight, include 1.5-2.5 parts lotus leaf, 1.0-1.5 parts dried tangerine peel, 1.0-1.5 parts mulberry leaf, 1.0-1.5 parts chrysanthemum, 1.0-1.5 parts Imperata cylindrica root, 1.5-2.5 parts Astragalus membranaceus, 2.0-2.6 parts roasted malt, 10.0-15.0 parts roasted hawthorn, 16.0-22.0 parts roasted coix seed, 10.0-15.0 parts red adzuki bean, and 48.0-58.0 parts mulberry extract.

2. The Five Brightness Ointment for Lightening the Body according to claim 1, characterized in that: The ingredients, in the following proportions by weight, include 2.04 parts lotus leaf, 1.22 parts dried tangerine peel, 1.22 parts mulberry leaf, 1.22 parts chrysanthemum, 1.22 parts Imperata cylindrica root, 2.04 parts astragalus, 2.30 parts roasted malt, 12.69 parts roasted hawthorn, 19.04 parts roasted coix seed, 12.69 parts red adzuki bean, and 53.76 parts mulberry extract.

3. A method for preparing a light-body five-brightness ointment according to any one of claims 1-2, characterized in that, The process includes the following steps: S1. Raw material chemical grouping: The raw materials are grouped according to their chemical properties and physical characteristics, including Group A of volatile flavonoids, Group B of polysaccharides, and Group C of fat-soluble dietary fiber. S2. Targeted Extraction and Processing: Groups A, B, and C were extracted and processed separately to obtain extracts from Group A, volatile oil fractions, extracts from Group B, and micro / nano mud-like substances from Group C. S3. Synergistic Inclusion and Concentration: The extracts from group A and group B were combined and concentrated under reduced pressure at a vacuum of -0.08 to -0.09 MPa and a temperature of 60-70℃. The relative density of the sample was measured at 85℃ to be 1.13-1.14, yielding a concentrated herbal extract. The volatile oil fraction was then encapsulated with β-cyclodextrin and mixed into the concentrated herbal extract. S4. Construction and preparation of bistable colloid: Mix the concentrated herbal extract and mulberry extract by weight ratio of 1000:7323, and add the micro-nano mud-like material of group C. Adjust the Zeta potential of the system to -25mV to -35mV while stirring, heat and cook until the relative density is 1.20-1.21 and the moisture content is 50-55% at 20℃ to obtain a semi-finished paste. S5. Filling and Sterilization: Fill the semi-finished ointment at 30-40℃, seal it, and sterilize it at 105℃ for 25 minutes to obtain the finished product, Qing Shen Wu Ming Ointment.

4. The method for preparing a light-body five-brightness ointment according to claim 3, characterized in that, The specific details of the chemical grouping of raw materials mentioned in step S1 are as follows: Group A of volatile flavonoids includes lotus leaf, dried tangerine peel, mulberry leaf and chrysanthemum, which are rich in volatile oils and heat-sensitive flavonoid glycosides; Group B of polysaccharides includes Imperata cylindrica root, Astragalus membranaceus, and roasted malt, which are rich in polysaccharides and saponins. Group C of fat-soluble dietary fiber includes seedless roasted hawthorn, roasted Job's tears, and red beans, which are rich in fat-soluble active ingredients and insoluble dietary fiber.

5. The method for preparing a light-body five-brightness ointment according to claim 3, characterized in that, The targeted extraction and processing described in step S2 are as follows: S2.1 Extraction of Group A: Mix the raw materials of Group A, add 8-10 times the amount of water, and soak at 40-50℃ for 30 minutes; perform steam distillation extraction for 1.5 hours, collect the volatile oil fraction, and boil the residue twice, adding 6-8 times the amount of water each time, and boil for 2 hours each time. Combine the filtrates to obtain the extract of Group A. S2.2 Extraction of Group B: Mix the raw materials of Group B, add 10-12 times the amount of water, add 0.3% of the weight of the raw materials of the compound enzyme preparation, enzymatically hydrolyze at 45℃ for 1 hour, then ultrasonically extract for 30 minutes at 300W power and 40kHz frequency, then heat to 95℃ to inactivate the enzyme and decoct for 1.5 hours, and filter to obtain the extract of Group B; the compound enzyme preparation is cellulase: pectinase = 2:1, w / w; S2.3, Group C micro-nano processing: The Group C raw materials were placed in a medicinal cloth bag, placed in an extraction tank with twice the amount of water, and pressure-cooked for 1.5 hours at 0.10-0.15 MPa. After removal, they were mixed with a portion of mulberry extract and subjected to three-stage gradient micro-nano homogenization through a colloid mill. The first stage gap was 40±5 μm, the second stage gap was 30±3 μm, and the third stage gap was 20±2 μm. The particle size D50 was controlled to be 15-35 μm to obtain Group C micro-nano mud.

6. The method for preparing a light-body five-brightness ointment according to claim 5, characterized in that: In the extraction of group A described in step S2.1, the steam flow rate of steam distillation is 150-200 mL / min, and the collected volatile oil is encapsulated with 8-10 times the amount of β-cyclodextrin at 40°C for 2 hours.

7. The method for preparing a light-body five-brightness ointment according to claim 5, characterized in that: In the extraction of group B described in step S2.2, the cellulase activity in the compound enzyme preparation is ≥10000u / g, the pectinase activity is ≥30000u / g, and the enzymatic hydrolysis pH is controlled at 4.5-5.

0.

8. The method for preparing a light-body five-brightness ointment according to claim 5, characterized in that: In the micro-nano processing of group C described in step S2.3, the pharmaceutical cloth bag is made of 400-mesh nylon material with a pore size of 38μm; the colloid mill speed is 3000rpm, and each stage is cycled once.

9. The method for preparing a light-body five-brightness ointment according to claim 3, characterized in that: The Zeta potential control range mentioned in step S4 is -30mV to -32mV.

10. The method for preparing a light-body five-brightness ointment according to claim 3, characterized in that: The mulberry extract described in step S4 is prepared by low-temperature vacuum concentration, with a temperature not exceeding 60°C, a vacuum degree of -0.085MPa or higher, and an anthocyanin retention rate of ≥85%.

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