Sample analysis equipment as well as redissolving device and control method thereof

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses sample analysis equipment, a redissolving device and a control method of the sample analysis equipment. The sample analysis equipment comprises a redissolution device, a sample determination device, a transmission device and a control device, the redissolution device comprises a reconstitution fluid separate injection mechanism, a first transfer mechanism and a carrier scheduling mechanism, and the reconstitution fluid separate injection mechanism is used for executing a reconstitution fluid separate injection action on a standard sample container loaded with a freeze-dried standard sample; the first transfer mechanism is used for transferring the standard sample container to the first container carrier; the carrier dispatching mechanism is used for dispatching a first container carrier loaded with a standard sample container from the redissolving device to the transmission device; and the transmission device is used for transmitting the first container carrier loaded with the standard sample container to the sample determination device. According to the invention, automatic redissolution of the freeze-dried standard sample in the sample analysis equipment is realized, and the redissolved freeze-dried standard sample is automatically conveyed to the sample determination device through the carrier for determination.

Description

Technical Field

[0001] This invention relates to the field of in vitro diagnostic equipment, and more particularly to a sample analysis device, a reconstitution apparatus for the sample analysis device, and a control method for the sample analysis device. Background Technology

[0002] In related technologies, to achieve a longer shelf life, standard samples such as quality control samples and calibrators are generally produced and stored in lyophilized form (e.g., lyophilized powder). Before analysis, laboratory operators manually reconstitute the lyophilized standard samples into liquid standard samples, which are then manually placed into the sample analysis equipment for measurement. To control costs, some laboratories require the reconstituted lyophilized standard samples to be aliquoted into smaller sizes. Taking quality control samples as an example, the first container used to hold lyophilized quality control samples is mostly around 1 ml, while the amount of quality control sample required for a single quality control measurement is much less than 1 ml. Therefore, some laboratories require the 1 ml of liquid quality control sample reconstituted in the first container to be aliquoted into five 200 μL second containers. The liquid quality control sample in one second container is manually placed into the sample analysis equipment for measurement, while the liquid quality control samples in the other four second containers are refrigerated or frozen.

[0003] In related technologies, lyophilized standard samples are manually reconstituted, aliquoted, and then placed into sample analysis equipment for measurement. This approach has the following drawbacks in practical applications: 1) The reconstitution, aliquoting, and transfer of lyophilized standard samples are complex, have a low degree of automation, and require a significant amount of work from laboratory personnel, increasing their workload; 2) The reconstitution of lyophilized standard samples is done manually, and the operating parameters rely on the operator's experience, which can easily lead to human error in the reconstitution quality of lyophilized standard samples. In other words, the reconstitution quality of manual reconstitution is random, which can easily affect the accuracy of the liquid standard sample measurement results and even lead to the loss of control over the liquid standard sample measurement items; 3) The sample analysis equipment only measures the sample to be tested after the standard sample measurement is passed, so the lead time for standard sample measurement will affect the clinical working time of the sample analysis equipment. Summary of the Invention

[0004] The first objective of this invention is to provide a sample analysis device that addresses the technical problem in related sample analysis devices where lyophilized standard samples are manually reconstituted into liquid standard samples before measurement, resulting in a heavy workload for operators and inaccurate measurement results due to human factors.

[0005] To achieve the above objectives, the present invention provides a sample analysis device, comprising:

[0006] A reconstitution device, wherein the reconstitution device is used to reconstitute lyophilized standard samples into liquid standard samples;

[0007] A sample measuring device is used to measure the sample to be tested to obtain sample detection data, and to measure the liquid standard sample to obtain reference detection data.

[0008] A transmission device, the transmission device being used to: transmit a first container carrier containing a standard sample container, wherein the standard sample container contains at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample in the reconstitution device, to the sample determination device;

[0009] A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device;

[0010] The reconstitution device includes a reconstitution solution dispensing mechanism, a first transfer mechanism, and a carrier scheduling mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on the standard sample container loaded with the lyophilized standard sample, so as to reconstitute the lyophilized standard sample with the reconstitution solution to form the liquid standard sample.

[0011] The first transfer mechanism is used to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier;

[0012] The carrier scheduling mechanism is used to schedule the first container carrier, which is loaded with the standard sample container and the standard sample container is loaded with at least part of the liquid standard sample, from the reconstitution device to the transmission device.

[0013] In one embodiment, the remelting apparatus further includes a carrier buffer mechanism, which is at least used to buffer the first container carrier when it is in an empty state;

[0014] The first transfer mechanism transfers the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier, including: the first transfer mechanism transferring the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier from the carrier buffer mechanism.

[0015] In one embodiment, the reconstitution apparatus further includes a storage mechanism, which is at least used to store the standard sample container containing the lyophilized standard sample;

[0016] The reconstitution dispensing mechanism performs a reconstitution dispensing action on the standard sample container containing the lyophilized standard sample, including: the reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container from the storage mechanism that contains the lyophilized standard sample.

[0017] In one embodiment, the carrier buffer mechanism is further used to buffer the first container carrier that contains the standard sample container and the standard sample container contains the freeze-dried standard sample;

[0018] The first transfer mechanism is also used to transfer the standard sample container containing the freeze-dried standard sample from the first container carrier from the carrier buffer mechanism to the storage mechanism.

[0019] In one embodiment, the reconstitution apparatus further includes a rewarming mechanism, which is at least used to perform a rewarming process on the standard sample container from the storage unit and containing the lyophilized standard sample.

[0020] The reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that comes from the storage unit and contains the lyophilized standard sample, including: the reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that comes from the storage unit and has completed the rewarming treatment;

[0021] Preferably, in the first horizontal direction, the rewarming mechanism is located between the storage mechanism and the carrier buffer mechanism; in the second horizontal direction, the rewarming mechanism and the carrier buffer mechanism are located on the side of the carrier scheduling mechanism away from the sample measuring device, and the first horizontal direction and the second horizontal direction are perpendicular to each other.

[0022] In one embodiment, the reconstitution device further includes a mixing mechanism, which is used to perform a mixing action on the standard sample container after the reconstitution dispensing action is completed, so as to mix the liquid standard sample formed by the reconstitution of the lyophilized standard sample in the standard sample container.

[0023] The first transfer mechanism transfers the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier from the carrier buffer mechanism, including: the first transfer mechanism transferring the standard sample container after the mixing action is completed to the first container carrier from the carrier buffer mechanism;

[0024] Preferably, in the first horizontal direction, the mixing mechanism is located between the reheating mechanism and the storage mechanism.

[0025] In one embodiment, the mixing mechanism includes a mixing seat and a mixing power assembly. The first transfer mechanism is further used to transfer the standard sample container, which has completed the reconstitution dispensing action and contains at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample, to the mixing seat.

[0026] The mixing power assembly performs the mixing action on the standard sample container placed in the mixing seat by at least one of the following methods: driving the mixing seat to rotate, driving the mixing seat to vibrate, performing suction and discharge actions on the liquid standard sample in the standard sample container placed in the mixing seat, blowing air onto the liquid standard sample in the standard sample container placed in the mixing seat, performing stirring action on the liquid standard sample in the standard sample container placed in the mixing seat, and performing ultrasonic mixing action on the liquid standard sample in the standard sample container placed in the mixing seat.

[0027] In one embodiment, the mixing seat includes a first clamping seat, a second clamping seat, and a first elastic member. The first clamping seat has a first groove, and the second clamping seat has a second groove. The first clamping seat and the second clamping seat are spliced ​​together and rotatably connected in such a way that the first groove and the second groove are directly opposite each other, so that the first groove and the second groove enclose a receiving cavity. The receiving cavity is used for at least partial insertion and positioning of the standard sample container. The two ends of the first elastic member are respectively connected to the first clamping seat and the second clamping seat so that the first groove and the second groove tend to move closer to each other.

[0028] And / or, the mixing power assembly includes a first motor and a first transmission component, wherein the first transmission component is tractively connected between the first motor and the mixing seat to drive the mixing seat to rotate under the drive of the first motor.

[0029] In one embodiment, the reheating mechanism has a reheat solution dispensing position and multiple receiving positions;

[0030] The first transfer mechanism is also used to transfer the standard sample container containing the lyophilized standard sample from the storage mechanism to the receiving position;

[0031] The rewarming mechanism performs a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample, including: the rewarming mechanism performs a rewarming process on the standard sample container that has been transferred from the storage mechanism to the receiving position by the first transfer mechanism.

[0032] The first transfer mechanism is also used to transfer the standard sample container after the rewarming treatment from the holding position to the reconstitution solution dispensing position;

[0033] The reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that has come from the storage mechanism and completed the rewarming treatment, including: the reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that has been transferred from the receiving position to the reconstitution dispensing position by the first transfer mechanism.

[0034] In one embodiment, the first transfer mechanism is further configured to transfer the standard sample container after the reconstitution solution dispensing action is completed from the reconstitution solution dispensing position to the receiving position, so that the standard sample container can undergo a first settling treatment at the receiving position; the first transfer mechanism is further configured to transfer the standard sample container after the first settling treatment is completed from the receiving position to the mixing mechanism;

[0035] And / or, the first transfer mechanism is further configured to transfer the standard sample container after the mixing action is completed from the mixing mechanism to the receiving position, so that the standard sample container can undergo a second settling treatment at the receiving position; the first transfer mechanism transferring the standard sample container after the mixing action is completed to the first container carrier from the carrier buffer mechanism includes: the first transfer mechanism transferring the standard sample container after the second settling treatment from the receiving position to the first container carrier from the carrier buffer mechanism.

[0036] In one embodiment, the reconstitution device further includes a cleaning mechanism, which is used to perform a cleaning action on the reconstitution dispensing mechanism after the reconstitution dispensing action is completed;

[0037] Preferably, in the first horizontal direction, the cleaning mechanism is located between the storage mechanism and the reheating mechanism.

[0038] In one embodiment, a first unloading position is formed within the remelting device;

[0039] The vehicle scheduling mechanism is also used to schedule the standard sample container, which is loaded with the standard sample container and the standard sample container is loaded with the freeze-dried standard sample, from the vehicle buffer mechanism to the first unloading position;

[0040] The first transfer mechanism transfers the standard sample container loaded with freeze-dried standard samples from the first container carrier from the carrier buffer mechanism to the storage mechanism, including: the first transfer mechanism transfers the standard sample container loaded with freeze-dried standard samples from the first container carrier scheduled to the first unloading position by the carrier scheduling mechanism to the storage mechanism.

[0041] The vehicle scheduling mechanism is also used to schedule the first container vehicle, which has been transferred to the standard sample container by the first transfer mechanism and is in an empty state, from the first unloading position to the vehicle buffer mechanism.

[0042] Preferably, in the first horizontal direction, the first unloading position is located between the rewarming mechanism and the vehicle buffer mechanism.

[0043] In one embodiment, the remelting apparatus also includes a first loading position;

[0044] The vehicle scheduling mechanism is also used to schedule the first container vehicle, which is in an empty state, from the vehicle buffer mechanism to the first loading position;

[0045] The first transfer mechanism transfers the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier from the carrier buffer mechanism, including: transferring the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier scheduled to the first loading position by the carrier scheduling mechanism;

[0046] The carrier scheduling mechanism schedules the first container carrier, which is loaded with the standard sample container and at least part of the liquid standard sample, from the reconstitution device to the transmission device, including: the carrier scheduling mechanism schedules the first container carrier, which is loaded with the standard sample container and at least part of the liquid standard sample, from the first loading position to the transmission device.

[0047] The first loading position and the first unloading position may be located at the same position or at different positions;

[0048] Preferably, in the first horizontal direction, the first loading position is located between the rewarming mechanism and the vehicle buffer mechanism.

[0049] In one embodiment, the reconstitution apparatus further includes a feeding mechanism, which is used to place the first container carrier containing the standard sample container and the standard sample container containing the lyophilized standard sample to realize the feeding of the lyophilized standard sample, or the feeding mechanism is used to place the standard sample container containing the lyophilized standard sample on the first container carrier located in the feeding mechanism to realize the feeding of the lyophilized standard sample.

[0050] The carrier scheduling mechanism is also used to schedule the first container carrier, which is loaded with the standard sample container and the standard sample container is loaded with the freeze-dried standard sample, from the loading mechanism to the carrier buffer mechanism or the first unloading position.

[0051] Preferably, the feeding mechanism is located above the vehicle buffer mechanism;

[0052] Preferably, the feeding mechanism is further configured to place the first container carrier containing the standard sample container and the standard sample container containing the liquid standard sample to realize the feeding of the liquid standard sample, or the feeding mechanism is further configured to place the standard sample container containing the liquid standard sample on the first container carrier located in the feeding mechanism to realize the feeding of the liquid standard sample.

[0053] In one embodiment, the transmission device is further configured to transmit the first container carrier, which contains the standard sample container and the standard sample container contains the lyophilized standard sample, to the reconstitution device.

[0054] The vehicle scheduling mechanism is also used to schedule the first container vehicle, which comes from the transmission device and is loaded with the standard sample container and the standard sample container is loaded with the freeze-dried standard sample, to the vehicle buffer mechanism or the first unloading position.

[0055] In one embodiment, the reconstitution device further includes a first information acquisition component, which is used to acquire information of a first identification code on the standard sample container before the standard sample container is transferred to the storage mechanism by the first transfer mechanism; preferably, in the first horizontal direction, the first information acquisition component is located between the storage mechanism and the rewarming mechanism; preferably, in the second horizontal direction, the first information acquisition component is arranged side by side with the mixing mechanism.

[0056] And / or, the reconstitution apparatus further includes a second information acquisition component, which is used to acquire information about a second identification code on the first container carrier at at least the following times: before the first transfer mechanism transfers the standard sample container loaded with the lyophilized standard sample from the first container carrier located at the first unloading position; before the first transfer mechanism transfers the standard sample container from the storage mechanism and loaded with the liquid standard sample to the first container carrier located at the first loading position; and before the first transfer mechanism transfers the standard sample container loaded with the liquid standard sample from the first container carrier located at the first unloading position. Preferably, the second information acquisition component is used to acquire information about the second identification code on the first container carrier located at the first unloading position or at the first loading position.

[0057] In one embodiment, the reconstitution apparatus further includes a reconstitution solution buffer mechanism for storing a second container carrier containing a reconstitution solution container and the reconstitution solution container containing a reconstitution solution.

[0058] The reconstitution dispensing mechanism performs a reconstitution dispensing action on the standard sample container containing the lyophilized standard sample, including: the reconstitution dispensing mechanism draws at least a portion of the reconstitution solution from the reconstitution container loaded on the second container carrier from the reconstitution buffer mechanism, and dispenses the drawn at least a portion of the reconstitution solution into the standard sample container containing the lyophilized standard sample;

[0059] Preferably, in the first horizontal direction, the reconstitution buffer mechanism is located between the first unloading position and the vehicle buffer mechanism.

[0060] In one embodiment, the feeding mechanism is further configured to place the second container carrier containing the reconstituted solution container and the reconstituted solution container being filled with the reconstituted solution to realize the feeding of the reconstituted solution, or to place the reconstituted solution container containing the reconstituted solution on the second container carrier located in the feeding mechanism to realize the feeding of the reconstituted solution; the carrier scheduling mechanism is further configured to: schedule the second container carrier containing the reconstituted solution container and the reconstituted solution container being filled with the reconstituted solution from the feeding mechanism to the reconstituted solution buffer mechanism;

[0061] Alternatively, the transmission device is further configured to transmit the second container carrier, which is loaded with the reconstituted solution container and the reconstituted solution container is loaded with the reconstituted solution, to the reconstituted device; the carrier scheduling mechanism is further configured to schedule the second container carrier, which is loaded with the reconstituted solution container and the reconstituted solution container, from the transmission device to the reconstituted solution buffer mechanism.

[0062] In one embodiment, the vehicle scheduling mechanism includes a base, an entry / exit drive assembly, and a spatial motion assembly. The base forms a vehicle accommodating channel. The first container vehicle has a first base with a width adapted to the width of the vehicle accommodating channel, and the second container vehicle has a second base with a width adapted to the width of the vehicle accommodating channel.

[0063] The entry / exit drive assembly is used to drive the first base to move into and out of the vehicle accommodating channel and to drive the second base to move into and out of the vehicle accommodating channel.

[0064] The spatial motion component is used to drive the carrier and the entry / exit drive component to perform spatial motion, so as to move the carrier accommodating channel to at least the position docked with the loading mechanism, the position docked with the carrier buffer mechanism, the position docked with the first unloading position, the position docked with the first loading position, and the position docked with the transmission device.

[0065] In one embodiment, the first substrate is a first container rack, which has at least two first placement positions, each of which is used to place a single standard sample container.

[0066] Alternatively, the first substrate may be a first container holder having a single second placement position for placing a single standard sample container.

[0067] In one embodiment, the first base is a first container frame, the width of the second base is the same as the width of the first container frame, and the second container carrier further includes a receiving seat, the receiving seat is disposed on the top of the second base, and the top of the receiving seat is provided with a cavity, the cavity being used for positioning at least part of the reconstituted solution container.

[0068] In one embodiment, the reconstitution apparatus further includes a storage mechanism and a door drive mechanism, wherein the storage mechanism is used to store the standard sample container containing the lyophilized standard sample;

[0069] The storage mechanism includes a storage compartment and a compartment door. The storage compartment is a refrigerated compartment or a frozen compartment. The storage compartment is provided with a compartment opening for the first transfer mechanism to take out and put in the standard sample container. The compartment door is provided at the compartment opening for opening or closing the compartment opening.

[0070] The door drive mechanism is used to drive the door to move, so that the door opens or closes the opening.

[0071] Wherein, the door drive mechanism and the first transfer mechanism are either the same mechanism or two different mechanisms;

[0072] Preferably, the door is formed at the top of the storage compartment.

[0073] In one embodiment, the reconstitution device further includes a first display screen, which is used to display management information of the standard sample container and / or management information of the reconstitution container.

[0074] In one embodiment, the reconstitution device further includes a storage mechanism, a reheating mechanism, a reconstitution solution buffer mechanism, and a carrier buffer mechanism;

[0075] The storage mechanism is used to store the standard sample container containing the freeze-dried standard sample;

[0076] The rewarming mechanism is used at least to perform a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample;

[0077] The vehicle buffer mechanism is used at least to buffer the first container vehicle when it is in an empty state;

[0078] The reconstituted solution buffer mechanism is used to store a second container carrier containing a reconstituted solution container and the reconstituted solution container is filled with a reconstituted solution.

[0079] The resolution device also has a first loading position and a first unloading position, and the first loading position and the first unloading position are located at the same position.

[0080] The vehicle scheduling mechanism, the rehydration solution buffer mechanism, the first loading position, the reheating mechanism, and the storage mechanism are arranged sequentially along the first horizontal direction;

[0081] In the second horizontal direction, the vehicle scheduling mechanism, the reconstitution buffer mechanism, the first loading position, and the rewarming mechanism are all located on the side of the vehicle scheduling mechanism away from the sample measuring device;

[0082] Wherein, the first horizontal direction is perpendicular to the second horizontal direction.

[0083] In one embodiment, the reconstitution device further includes a feeding mechanism, a storage mechanism, a reheating mechanism, a reconstitution solution buffer mechanism, and a carrier buffer mechanism;

[0084] The feeding mechanism is used to place the first container carrier containing the standard sample container and the standard sample container containing the lyophilized standard sample to realize the feeding of the lyophilized standard sample, or the feeding mechanism is used to place the standard sample container containing the lyophilized standard sample on the first container carrier located in the feeding mechanism to realize the feeding of the lyophilized standard sample; and the feeding mechanism is also used to place the second container carrier containing the reconstituted solution container and the reconstituted solution container containing the reconstituted solution to realize the feeding of the reconstituted solution, or to place the reconstituted solution container containing the reconstituted solution on the second container carrier located in the feeding mechanism to realize the feeding of the reconstituted solution;

[0085] The storage mechanism is at least used to store the standard sample container containing the freeze-dried standard sample;

[0086] The rewarming mechanism is used at least to perform a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample;

[0087] The vehicle buffer mechanism is used at least to buffer the first container vehicle when it is in an empty state;

[0088] The reconstituted solution buffer mechanism is used to store a second container carrier containing a reconstituted solution container and the reconstituted solution container is filled with a reconstituted solution.

[0089] The reconstitution device has a first layer of space and a second layer of space. The second layer of space is located above the first layer of space and is connected to the first layer of space. The storage mechanism, the reheating mechanism, the reconstitution buffer mechanism and the carrier buffer mechanism are distributed in the first layer of space, and the feeding mechanism is distributed in the second layer of space.

[0090] In one embodiment, a third space is also formed within the resolution device, and the third space is located below the first space;

[0091] The first layer of space is provided with a recycling port that communicates with the third layer of space. The third layer of space is used to place the recycling container, and the recycling container is used to recycle the standard sample container discarded through the recycling port.

[0092] The first transfer mechanism is also used to transfer the standard sample container that meets one of the following conditions to the recycling port for disposal: the standard sample container is filled with the liquid standard sample and the remaining amount of the liquid standard sample is insufficient; the standard sample container is filled with the liquid standard sample and the shelf life of the liquid standard sample has expired; or the standard sample container is filled with the lyophilized standard sample and the shelf life of the lyophilized standard sample has expired.

[0093] In one embodiment, the first transfer mechanism includes a clamping assembly and a horizontal driving assembly. The clamping assembly is used to clamp or release the standard sample container, and the horizontal driving assembly is connected to the clamping assembly to drive the clamping assembly to move horizontally.

[0094] The reconstitution dispensing mechanism includes a pipette for dispensing the reconstitution solution into the standard sample container containing the lyophilized standard sample. The horizontal drive assembly is also connected to the pipette to drive the pipette to move horizontally.

[0095] In one implementation, the first transfer mechanism includes:

[0096] A clamping assembly includes a mounting base, a first clamping arm, a second clamping arm, a second elastic element, a second motor, and a second transmission component. One end of the first clamping arm and one end of the second clamping arm are rotatably connected to the mounting base. The two ends of the second elastic element are respectively connected to the first clamping arm and the second clamping arm so that the other ends of the first clamping arm and the other ends of the second clamping arm tend to approach each other. The second transmission component is disposed between the first clamping arm and the second clamping arm. The second motor is mounted on the mounting base and is drively connected to the second transmission component to drive the second transmission component to switch between a first state and a second state. In the first state, the distance between the other ends of the first clamping arm and the second clamping arm is smaller than the distance between the other ends of the first clamping arm and the second clamping arm in the second state. The first clamping arm and the second clamping arm are used to clamp the standard sample container when the second transmission component is in the first state, and the first clamping arm and the second clamping arm are used to release the standard sample container when the second transmission component is in the second state.

[0097] A first lifting drive assembly is connected to the mounting base to drive the clamping assembly to move up and down.

[0098] A horizontal drive assembly, which is connected to the first lifting drive assembly, is used to drive the first lifting drive assembly to move the clamping assembly horizontally;

[0099] The reconstitution dispensing mechanism further includes a second lifting drive assembly, which is connected to the pipette to drive the pipette to move up and down. The horizontal drive assembly is also connected to the second lifting drive assembly to drive the second lifting drive assembly to move the pipette horizontally.

[0100] The first lifting drive component and the second lifting drive component are either two different lifting drive components or the same lifting drive component.

[0101] In one embodiment, the second transmission component includes a cam component. Preferably, the cam component includes a first abutment and a second abutment. In the first state, at least one of the first abutment and the second abutment abuts against both the first clamping arm and the second clamping arm. In the second state, the first abutment abuts against the first clamping arm but not against the second clamping arm, and the second abutment abuts against the second clamping arm but not against the first clamping arm.

[0102] And / or, the clamping assembly further includes a third elastic element, one end of which is connected to one of the first clamping arm and the second clamping arm, and the other end of which is connected to the mounting base.

[0103] In one embodiment, the reconstitution device further includes a first housing, within which the reconstitution dispensing mechanism, the first transfer mechanism, and the carrier scheduling mechanism are all located; the transmission device includes a transmission track, outside which both the transmission track and the sample determination device are located, and the first housing has an output port directly opposite one end of the transmission track; the carrier scheduling mechanism is used to schedule the first container carrier, which contains at least a portion of the liquid standard sample, to the transmission track through the output port.

[0104] And / or, the sample determination device includes a second housing, the reconstitution device and the transmission device are both located outside the second housing, and the reconstitution device and the transmission device are located on adjacent sides of the second housing.

[0105] In one embodiment, the standard sample container includes a glass bottle and a sealing member. The glass bottle has an inner cavity and a bottle mouth. The inner cavity is used to contain a lyophilized standard sample and a liquid standard sample formed by reconstitution of the lyophilized standard sample. The bottle mouth communicates with the inner cavity to allow at least a portion of the liquid standard sample to be drawn out of the inner cavity.

[0106] The sealing member is used to seal the bottle opening, and the sealing member includes a bottle stopper that is at least partially inserted into the bottle opening and / or a bottle cap that is at least partially fitted outside the bottle opening;

[0107] The reconstitution dispensing mechanism includes a pipette with a puncture function. The pipette is used to puncture the stopper and / or cap of the standard sample container to at least partially penetrate the standard sample container and dispense the reconstitution solution into the standard sample container.

[0108] In one embodiment, the reconstitution apparatus further includes a storage mechanism, a reheating mechanism, and a mixing mechanism;

[0109] The control device is configured to:

[0110] When the first preset condition is met, the first transfer mechanism is controlled to transfer the standard sample container containing the freeze-dried standard sample from the storage mechanism to the receiving position of the rewarming mechanism for rewarming treatment.

[0111] The first transfer mechanism is controlled to transfer the standard sample container, after the rewarming treatment, from the holding position to the reconstitution solution dispensing position;

[0112] The reconstitution solution dispensing mechanism is controlled to perform a reconstitution solution dispensing action on the standard sample container located at the reconstitution solution dispensing position;

[0113] The first transfer mechanism is controlled to transfer the standard sample container, after the reconstitution solution dispensing action is completed, from the reconstitution solution dispensing position to the receiving position to perform the first settling process;

[0114] The first transfer mechanism is controlled to transfer the standard sample container, after the first settling treatment, from the holding position to the mixing mechanism;

[0115] The mixing mechanism is controlled to perform a mixing action on the standard sample container after the first settling treatment is completed;

[0116] The first transfer mechanism is controlled to transfer the standard sample container, after the mixing action is completed, from the mixing mechanism to the receiving position to perform the second settling process;

[0117] The first transfer mechanism is controlled to transfer the standard sample container, after the second settling treatment, from the receiving position to the first container carrier located at the first loading position;

[0118] The vehicle scheduling mechanism controls the first container vehicle, which is loaded with the standard sample container and has completed the second settling process, to be scheduled from the first loading position to the transmission device.

[0119] The control system transfers the first container carrier, which is dispatched to it by the carrier scheduling mechanism and is loaded with the standard sample container, to the sample determination device.

[0120] The sample measuring device is controlled to draw at least a portion of the liquid standard sample loaded in the standard sample container from the first container carrier of the transmission device and dispense it into the first reaction container. The sample measuring device is controlled to measure the first reaction liquid in the first reaction container, which is made from at least the liquid standard sample dispensed into the first reaction container, to obtain the reference detection data.

[0121] Preferably, the lyophilized standard sample is a lyophilized quality control product, and the reference test data is quality control data; the sample analysis device is pre-stored with at least one of the following first preset conditions: reaching a first preset time point of a first preset cycle, the cumulative running time of the sample analysis device since the last quality control item measurement reaching a first preset time, the number of times the sample analysis device continuously measures the sample to be tested reaching a first preset number, the cumulative number of times the sample analysis device measures the sample to be tested since the last quality control item measurement reaching a second preset number, changing the reagent container to supply reagents, and obtaining information on the quality control item to be performed according to the instructions input by the operator through the human-computer interaction device.

[0122] In one implementation, the control device is further configured to:

[0123] The transmission device is controlled to transport the first container carrier, which outputs from the sample determination device and is loaded with the standard sample container, toward the reconstitution device;

[0124] The vehicle scheduling mechanism is controlled to schedule the first container vehicle, which comes from the transmission device and is loaded with the standard sample container, to the first unloading position;

[0125] The first transfer mechanism is controlled to transfer the standard sample container from the first container carrier, which has been dispatched to the first unloading position by the carrier scheduling mechanism, to the storage mechanism for storage or to the recycling port for disposal.

[0126] In one implementation, the freeze-dried standard sample is a freeze-dried quality control sample, and the reference test data is quality control data;

[0127] Alternatively, the lyophilized standard sample may be a lyophilized calibrator, and the reference test data may be calibration data.

[0128] In one embodiment, the reconstitution device is also used to reconstitute the lyophilized reagent into a first liquid reagent;

[0129] The reconstitution solution dispensing mechanism is also used to perform a reconstitution solution dispensing action on the first reagent container containing the lyophilized reagent, so as to reconstitute the lyophilized reagent with the reconstitution solution to form the first liquid reagent;

[0130] The first transfer mechanism is also used to transfer the first reagent container, which contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent, to the third container carrier;

[0131] The vehicle scheduling mechanism is also used to schedule the third container vehicle, which is loaded with the first reagent container and the first reagent container is loaded with at least part of the first liquid reagent, from the reconstitution device to the transmission device;

[0132] The transmission device is further configured to: transmit the third container carrier, which contains the first reagent container and the first reagent container contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent in the reconstitution device, to the sample determination device;

[0133] The sample testing device measures the sample to be tested to obtain sample test data, including: the sample testing device measures a test solution made of at least the sample to be tested and the first liquid reagent to obtain the sample test data;

[0134] Wherein, the third container carrier and the first container carrier are two independent carriers or are the same carrier;

[0135] Preferably, the sample determination device includes a reagent storage mechanism, a reagent dispensing mechanism, a sample dispensing mechanism, a second transfer mechanism, and a sample determination mechanism. The second transfer mechanism is used to transfer the first reagent container, which contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent, from the third container carrier to the reagent storage mechanism. The sample dispensing mechanism is used to draw the sample to be tested from the sample container and dispense it into the reaction container. The reagent dispensing mechanism is used to draw at least a portion of the first liquid reagent from the first reagent container in the reagent storage mechanism and dispense the drawn first liquid reagent into the reaction container. The sample determination mechanism is used to determine the test solution in the reaction container, which is at least composed of the sample to be tested and the first liquid reagent, to obtain the sample detection data.

[0136] A second objective of this invention is to provide a sample analysis device, which includes:

[0137] A reconstitution device, wherein the reconstitution device is used to reconstitute lyophilized standard samples into liquid standard samples;

[0138] A sample measuring device is used to measure the sample to be tested to obtain sample detection data, and to measure the liquid standard sample to obtain reference detection data.

[0139] A transmission device located outside the reconstitution device, and the transmission device being used to: transmit a first container carrier containing a standard sample container, wherein the standard sample container contains at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample in the reconstitution device, to the sample determination device;

[0140] A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device;

[0141] The reconstitution device includes a reconstitution solution dispensing mechanism and a first transfer mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on the standard sample container containing the lyophilized standard sample to reconstitute the lyophilized standard sample into the liquid standard sample using the reconstitution solution. The first transfer mechanism is used to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier located on the transfer device.

[0142] In one embodiment, the reconstitution device further includes a first housing, and the reconstitution solution dispensing mechanism is located inside the first housing;

[0143] The transmission device includes a transmission track, both of which are located outside the first housing, and the first housing has an output port that is directly opposite one end of the transmission track.

[0144] The first transfer mechanism is used to transfer, through the output port, the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier located on the transport track.

[0145] In one implementation, the control device is configured to:

[0146] The transport track is controlled to transport the first container carrier, which outputs from the sample determination device and is loaded with the standard sample container, toward the reconstitution device;

[0147] The first transfer mechanism is controlled to transfer the standard sample container from the first container carrier located on the transfer track to the reconstitution device for storage or recovery.

[0148] A third objective of this invention is to provide a sample analysis device, which includes:

[0149] A reconstitution apparatus, wherein the reconstitution apparatus is used to reconstitute a lyophilized reagent into a first liquid reagent;

[0150] A sample measuring device is used to measure a test solution made of at least the sample to be tested and the first liquid reagent to obtain the sample test data;

[0151] A transmission device, the transmission device being used to: transmit the third container carrier, which is loaded with the first reagent container and the first reagent container is loaded with at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent in the reconstitution device, to the sample determination device;

[0152] A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device;

[0153] The reconstitution device includes a reconstitution solution dispensing mechanism, a first transfer mechanism, and a carrier scheduling mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on a first reagent container loaded with the lyophilized reagent, so as to reconstitute the lyophilized reagent with the reconstitution solution to form the first liquid reagent.

[0154] The first transfer mechanism is used to transfer the first reagent container, which contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent, to the third container carrier;

[0155] The carrier scheduling mechanism is used to schedule the third container carrier, which is loaded with the first reagent container and at least part of the first liquid reagent, from the reconstitution device to the transmission device.

[0156] In one embodiment, the sample testing device includes a reagent storage mechanism, a reagent dispensing mechanism, a sample dispensing mechanism, a second transfer mechanism, and a sample testing mechanism. The second transfer mechanism is used to transfer a first reagent container containing at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent from the third container carrier to the reagent storage mechanism. The sample dispensing mechanism is used to draw the sample to be tested from the sample container and dispense it into the reaction container. The reagent dispensing mechanism is used to draw at least a portion of the first liquid reagent from the first reagent container in the reagent storage mechanism and dispense the drawn first liquid reagent into the reaction container. The sample testing mechanism is used to measure the test solution in the reaction container, which is at least composed of the sample to be tested and the first liquid reagent, to obtain the sample detection data.

[0157] A fourth objective of this invention is to provide a sample analysis device, which includes:

[0158] A reconstitution apparatus, wherein the reconstitution apparatus is used to reconstitute a lyophilized reagent into a first liquid reagent;

[0159] A sample measuring device is used to measure a test solution made of at least the sample to be tested and the first liquid reagent to obtain the sample test data;

[0160] A transfer device located outside the reconstitution device, and the transfer device being used to: transfer a third container carrier containing a first reagent container, wherein the first reagent container contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent in the reconstitution device, to the sample determination device;

[0161] A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device;

[0162] The reconstitution device includes a reconstitution solution dispensing mechanism and a first transfer mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on the first reagent container loaded with the lyophilized reagent to reconstitute the lyophilized reagent into the first liquid reagent through the reconstitution solution. The first transfer mechanism is used to transfer the first reagent container loaded with at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent to the third container carrier located on the transfer device.

[0163] A fifth object of the present invention is to provide a resolution apparatus comprising:

[0164] A first housing, the first housing having an output port;

[0165] A reconstitution solution dispensing mechanism is located inside the first outer shell and is used to perform a reconstitution solution dispensing action on a standard sample container containing a lyophilized standard sample, so as to reconstitute the lyophilized standard sample into a liquid standard sample through a reconstitution solution.

[0166] A first transfer mechanism is located inside the first housing and is used to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to a first container carrier.

[0167] A carrier scheduling mechanism is located inside the first housing and is used to output the first container carrier, which contains the standard sample container and at least part of the liquid standard sample, from the output port outside the first housing.

[0168] In one embodiment, the reconstitution device further includes a storage mechanism, a rewarming mechanism, a reconstitution solution buffer mechanism, and a carrier buffer mechanism, all of which are located within the first housing.

[0169] The storage mechanism is used to store the standard sample container containing the freeze-dried standard sample;

[0170] The rewarming mechanism is used to perform a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample;

[0171] The vehicle buffer mechanism is used at least to buffer the first container vehicle when it is in an empty state;

[0172] The reconstituted solution buffer mechanism is used to store a second container carrier containing a reconstituted solution container and the reconstituted solution container is filled with a reconstituted solution.

[0173] The resolution device also has a first loading position and a first unloading position, and the first loading position and the first unloading position are located at the same position.

[0174] The vehicle scheduling mechanism, the rehydration solution buffer mechanism, the first loading position, the reheating mechanism, and the storage mechanism are arranged sequentially along the first horizontal direction;

[0175] In the second horizontal direction, the vehicle scheduling mechanism, the rehydration solution buffer mechanism, the first loading position, and the reheating mechanism are all located on the same side of the vehicle scheduling mechanism;

[0176] Wherein, the first horizontal direction is perpendicular to the second horizontal direction.

[0177] In one embodiment, the remelting device further includes a feeding mechanism;

[0178] The feeding mechanism is used to place the first container carrier containing the standard sample container and the standard sample container containing the lyophilized standard sample to realize the feeding of the lyophilized standard sample, or the feeding mechanism is used to place the standard sample container containing the lyophilized standard sample on the first container carrier located in the feeding mechanism to realize the feeding of the lyophilized standard sample; and the feeding mechanism is also used to place the second container carrier containing the reconstituted solution container and the reconstituted solution container containing the reconstituted solution to realize the feeding of the reconstituted solution, or to place the reconstituted solution container containing the reconstituted solution on the second container carrier located in the feeding mechanism to realize the feeding of the reconstituted solution;

[0179] The reconstitution device has a first layer of space and a second layer of space, with the second layer of space located above the first layer of space. The storage mechanism, the reheating mechanism, the reconstitution solution buffer mechanism, and the carrier buffer mechanism are distributed in the first layer of space, and the feeding mechanism is distributed in the second layer of space.

[0180] In one embodiment, the reconstitution device further includes a first display screen located outside the first housing, the first display screen being used to display management information of the standard sample container and / or management information of the reconstitution solution container.

[0181] The sixth objective of this invention is to provide a control method for a sample analysis device, which includes the following steps:

[0182] The control reconstitution dispensing mechanism performs a reconstitution dispensing action on the standard sample container containing the lyophilized standard sample, so as to reconstitute the lyophilized standard sample to form a liquid standard sample through the reconstitution solution;

[0183] The first transfer mechanism is controlled to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier;

[0184] The control vehicle scheduling mechanism schedules the first container carrier, which is loaded with the standard sample container and the standard sample container is loaded with at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample, from the reconstitution device to the transmission device;

[0185] The control system will transfer the first container carrier, which is scheduled to be on the transmission device by the carrier scheduling mechanism, to the sample measuring device.

[0186] The sample measuring device is controlled to draw at least a portion of the liquid standard sample contained in the standard sample container and dispense it into the first reaction container. The sample measuring device is then controlled to measure the first reaction solution in the first reaction container, which is at least made from the liquid standard sample dispensed into the first reaction container, to obtain the reference detection data.

[0187] As one implementation, before the control reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container containing the lyophilized standard sample, the control method further includes the following steps: when a first preset condition is met, control the first transfer mechanism to transfer the standard sample container containing the lyophilized standard sample from the storage mechanism to the receiving position of the rewarming mechanism for rewarming treatment; control the first transfer mechanism to transfer the standard sample container after the rewarming treatment from the receiving position to the reconstitution dispensing position;

[0188] And / or, after the control reconstitution dispensing mechanism performs a reconstitution dispensing action on the standard sample container loaded with the lyophilized standard sample, and before the control first transfer mechanism transfers the standard sample container loaded with at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier; the control method further includes the following steps: controlling the first transfer mechanism to transfer the standard sample container after the reconstitution dispensing action from the reconstitution dispensing position to the receiving position to perform a first settling treatment; controlling the first transfer mechanism to transfer the standard sample container after the first settling treatment from the receiving position to the mixing mechanism; controlling the mixing mechanism to perform a mixing action on the standard sample container after the first settling treatment; controlling the first transfer mechanism to transfer the standard sample container after the mixing action from the mixing mechanism to the receiving position to perform a second settling treatment.

[0189] In one embodiment, after controlling the sample determination device to draw at least a portion of the liquid standard sample contained in the standard sample container and dispense it into the first reaction container, the control method further includes the following steps:

[0190] The transmission device is controlled to transport the first container carrier, which outputs from the sample determination device and is loaded with the standard sample container, toward the reconstitution device;

[0191] The vehicle scheduling mechanism is controlled to schedule the first container vehicle, which comes from the transmission device and is loaded with the standard sample container, to the first unloading position;

[0192] The first transfer mechanism is controlled to transfer the standard sample container from the first container carrier, which has been dispatched to the first unloading position by the carrier scheduling mechanism, to the storage mechanism for storage or to the recycling port for disposal.

[0193] The sample analysis equipment, reconstitution device, and control method provided by this invention reconstitute lyophilized standard samples into liquid standard samples using the reconstitution device, thereby achieving automatic reconstitution of lyophilized standard samples in the sample analysis equipment. Simultaneously, a first transfer mechanism of the reconstitution device transfers a standard sample container containing at least a portion of the liquid standard sample formed by the reconstitution of the lyophilized standard sample to a first container carrier. A carrier scheduling mechanism then schedules the first container carrier containing the standard sample container from the reconstitution device to a transmission device, which in turn transmits the first container carrier to the sample determination device for measurement. This achieves the effect of automatically transmitting the reconstituted lyophilized standard sample to the sample determination device for measurement, eliminating the need for manual intervention in the process of reconstituted lyophilized standard samples into liquid standard samples and the subsequent transmission. This improves the automation level of the sample analysis equipment, reducing the workload and operational burden on operators during standard sample determination, minimizing the impact of human factors on the standard sample determination results, ensuring the accuracy and validity of the results, and reducing the impact of the pre-determination time of standard sample determination on the clinical working time of the sample analysis equipment. Attached Figure Description

[0194] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.

[0195] Figure 1 This is a schematic diagram of the composition of the sample analysis device provided in the embodiment of the present invention;

[0196] Figure 2 This is a schematic diagram of the sample analysis device provided in an embodiment of the present invention;

[0197] Figure 3 This is a three-dimensional structural diagram of the remelting device provided in this embodiment of the invention after removing the first outer shell;

[0198] Figure 4 yes Figure 3 A top-down view;

[0199] Figure 5 This is a schematic diagram of the sample analysis device provided in this embodiment of the invention, in which the loading area and unloading area are set separately and the reconstitution device is set close to the unloading area;

[0200] Figure 6This is a schematic diagram of the sample analysis device provided in this embodiment of the invention, in which the loading area and unloading area are set separately and the reconstitution device is set close to the loading area;

[0201] Figure 7 This is a schematic diagram of the sample analysis device provided in this embodiment of the invention, in which the loading area and unloading area are arranged adjacently and close to the reconstitution device;

[0202] Figure 8 This is a schematic diagram of the sample analysis device provided in the embodiment of the present invention, in which the loading area and the unloading area are arranged adjacently and far away from the reconstitution device;

[0203] Figure 9 This is a schematic diagram of the sample analysis device provided in the embodiment of the present invention, in which the sample management device and the reconstitution device are arranged on opposite sides of the sample determination device;

[0204] Figure 10 This is a schematic diagram of the composition of the sample measuring device provided in an embodiment of the present invention;

[0205] Figure 11 This is a schematic diagram of the integrated structure of the first transfer mechanism and the reconstituted solution dispensing mechanism provided in an embodiment of the present invention;

[0206] Figure 12 This is a schematic diagram of the clamping assembly provided in an embodiment of the present invention in a closed state to clamp a standard sample container, from one perspective.

[0207] Figure 13 This is a schematic diagram of the clamping assembly provided in the embodiment of the present invention in a closed clamping state of a standard sample container, from another perspective.

[0208] Figure 14 This is a schematic diagram of the clamping assembly provided in an embodiment of the present invention in an open state to release the standard sample container, from one perspective.

[0209] Figure 15 This is a schematic diagram of the clamping assembly provided in an embodiment of the present invention in an open state to release the standard sample container, from another perspective.

[0210] Figure 16 This is a front view schematic diagram of the mixing mechanism provided in an embodiment of the present invention;

[0211] Figure 17 This is a three-dimensional structural diagram of a standard sample container placed on a mixing mechanism according to an embodiment of the present invention;

[0212] Figure 18 This is a three-dimensional structural schematic diagram of the second container carrier provided in an embodiment of the present invention;

[0213] Figure 19This is a three-dimensional structural schematic diagram of the vehicle scheduling mechanism provided in an embodiment of the present invention;

[0214] Figure 20 This is a three-dimensional structural diagram of the storage mechanism provided in an embodiment of the present invention;

[0215] Figure 21 This is a schematic diagram of the structure of the standard sample container provided in an embodiment of the present invention;

[0216] Figure 22 This is a schematic diagram of the reconstitution of the freeze-dried standard sample into a liquid standard sample in a standard sample container provided in an embodiment of the present invention;

[0217] Figure 23 This is a schematic diagram of the structure of a liquid standard sample provided in an embodiment of the present invention, which is loaded into a first container carrier through a standard sample container;

[0218] Figure 24 This is a schematic flowchart of the working mode for determining the first standard sample provided in an embodiment of the present invention;

[0219] Figure 25 This is a schematic flowchart of the working mode for determining the second standard sample provided in an embodiment of the present invention;

[0220] Figure 26 This is another schematic diagram of the sample measuring device provided in the embodiment of the present invention;

[0221] Figure 27 This is a schematic diagram illustrating the principle of the cap removal operation provided in an embodiment of the present invention;

[0222] Figure 28 This is a schematic diagram illustrating the principle of the de-plugging operation provided in an embodiment of the present invention;

[0223] Figure 29 This is another schematic diagram of the sample measuring device provided in the embodiments of the present invention.

[0224] Reference numerals: 10. Sample analysis equipment; 100. Sample measurement device; 110. Sample storage mechanism; 111. Loading area; 112. Unloading area; 113. Buffer area; 120. Sample scheduling mechanism; 130. Sample dispensing mechanism; 140. Sample measurement mechanism; 141. Incubation component; 142. Measurement component; 150. Reagent dispensing mechanism; 151. Mixed reagent dispensing mechanism; 152. Trigger reagent dispensing mechanism; 160. Reagent storage mechanism; 170. Reaction vessel supply mechanism; 180. Reaction vessel transfer mechanism; 190. Plug removal mechanism; 191. Plug removal needle; 1911. Hollow inner hole; 101. Cap removal mechanism; 102. First clamping mechanism; 103. 200. Second clamping mechanism; 210. Reconstitution device; 221. Reconstitution solution dispensing mechanism; 222. Mixing mechanism; 221. Mixing seat; 2211. First clamping seat; 2212. Second clamping seat; 2213. First elastic element; 2214. Fixed seat; 2215. First connecting shaft; 222. Mixing power assembly; 2221. First motor; 2222. First transmission component; 230. Storage mechanism; 231. Storage chamber; 2311. Chamber opening; 232. Chamber door; 240. Reheating mechanism; 241. Receptacle position; 242. Reconstitution solution dispensing position; 250. First transfer mechanism; 251. Clamping assembly; 2511. Mounting seat; 2512. First clamping arm; 2513. Second Clamping arm; 2514, second elastic element; 2515, second motor; 2516, second transmission component; 2501, cam component; 2502, first abutting element; 2503, second abutting element; 2517, third elastic element; 2518, second connecting shaft; 252, horizontal drive assembly; 260, feeding mechanism; 270, carrier scheduling mechanism; 271, carrier seat; 2711, carrier accommodating channel; 272, spatial motion component; 280, carrier buffer mechanism; 290, reconstituted solution buffer mechanism; 201, first information acquisition component; 202, second information acquisition component; 203, first display screen; 204, first outer shell; 205, cleaning mechanism; 206, recycling port; 20 7. First loading position; 208. First unloading position; 300. Transmission device; 310. Transmission track; 311. Sample injection position; 312. Inlet / outlet; 400. Control device; 500. Sample management device; 600. Third information acquisition component; 20. Standard sample container; 21. Glass bottle body; 22. Sealing component; 2201. Bottle stopper; 2202. Bottle cap; 2203. Through hole; 30. First container carrier; 40. Freeze-dried standard sample; 50. Liquid standard sample; 60. Second container carrier; 61. Second substrate; 62. Reservoir; 70. Reconstituted solution container; X1. First transmission direction; X2. Second transmission direction; X3. First horizontal direction; X4. Second horizontal direction. Detailed Implementation

[0225] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0226] This invention is applicable to equipment that uses lyophilized products reconstituted into liquid form as a working medium. These lyophilized products include, but are not limited to, lyophilized quality control products, lyophilized calibrators, and lyophilized reagents. Lyophilized quality control products are used to reconstitute into liquid quality control products for quality control measurements; lyophilized calibrators are used to reconstitute into liquid calibrators for calibration measurements; and lyophilized reagents are used to reconstitute into liquid reagents to mix with the sample to be tested to prepare the test solution. The sample to be tested is a liquid collected from a human or animal.

[0227] like Figures 1 to 29 As shown, a first aspect of the present invention provides a sample analysis device 10. The sample analysis device 10 includes a sample determination device 100, a reconstitution device 200, and a transfer device 300. The sample determination device 100 is used to determine the sample to be tested to obtain sample detection data, and to determine the liquid standard sample 50 to obtain reference detection data. The reconstitution device 200 is used to reconstitute the lyophilized standard sample 40 into a liquid standard sample 50. The transfer device 300 is used to transfer the liquid standard sample 50 output from the reconstitution device 200 to the sample determination device 100. The sample to be tested is a sample collected from a human or animal. The lyophilized standard sample 40 is prepared by a lyophilization process from a liquid standard sample 50 of known concentration (i.e., a liquid standard sample 50 with a known concentration of the target analyte, the target analyte being the same as all the target analytes detected in the sample to be tested). In this implementation scheme, the automatic reconstitution of the lyophilized standard sample 40 is achieved through the reconstitution device 200; the automatic transfer of the liquid standard sample 50 formed by reconstitution is achieved through the transfer device 300; and the liquid standard sample 50 is measured through the sample determination device 100. This allows the lyophilized standard sample 40 to be directly used on the sample analysis device 10, and realizes the automatic reconstitution and automatic measurement of the lyophilized standard sample 40 in the sample analysis device 10 after being used on the device. In this way, on the one hand, the workload and operational burden of the operator during the standard sample determination process are reduced, and on the other hand, the influence of human operation factors on the results of the standard sample determination items is reduced, ensuring the accuracy and validity of the standard sample determination items.

[0228] In one embodiment, the transfer device 300 is used to transfer a first container carrier 30 containing a standard sample container 20, wherein the standard sample container 20 contains at least a partially liquid standard sample 50 formed by reconstitution of lyophilized standard sample 40 in reconstitution device 200, to the sample analysis device 100. In this embodiment, the transfer device 300 uses the first container carrier 30 as a carrier to transfer the standard sample container 20, that is, the liquid standard sample 50 formed by reconstitution in reconstitution device 200 is transferred in the transfer device 300 via the first container carrier 30. In this way, on the one hand, the structural design of the first container carrier 30 can meet the transfer requirements of the transfer device 300, thereby making the sample analysis device 10 suitable for standard sample containers 20 of different specifications; on the other hand, it is beneficial to avoid the operator from touching the standard sample container 20, thus avoiding the risk of infection and / or contamination. Of course, in specific applications, as an alternative implementation, the method of transferring the liquid standard sample 50 formed by resolution in the resolution device 200 on the transfer device 300 is not limited to this. For example, as an alternative implementation, the liquid standard sample 50 formed by resolution in the resolution device 200 can also be transferred directly on the transfer device 300 through the standard sample container 20; or, the liquid standard sample 50 formed by resolution in the resolution device 200 can also be transferred on the transfer device 300 after being dispensed into other containers.

[0229] In one embodiment, the reconstitution apparatus 200 includes a reconstitution solution dispensing mechanism 210, which performs a reconstitution solution dispensing action on the standard sample container 20 containing the lyophilized standard sample 40, thereby reconstituted the lyophilized standard sample 40 into a liquid standard sample 50 using the reconstitution solution. The reconstitution apparatus 200 reconstitutes the lyophilized standard sample 40 into a liquid standard sample 50 by dispensing the reconstitution solution into the lyophilized standard sample 40 using the reconstitution solution dispensing mechanism 210, so that the lyophilized standard sample 40 and the reconstitution solution mix to form the liquid standard sample 50. In this embodiment, the lyophilized standard sample 40 is reconstituted by dispensing the reconstitution solution, that is, the reconstitution solution dispensing mechanism 210 dispenses the reconstitution solution into the standard sample container 20 containing the lyophilized standard sample 40, thereby dissolving the lyophilized standard sample 40 into a liquid standard sample 50 using the reconstitution solution, thus achieving automatic reconstitution of the lyophilized standard sample 40. This reconstitution method is simple and easy to implement. Furthermore, prior to this application, the reconstitution solution was dispensed manually, and the dispensing volume relied on the operator's experience, which could lead to human error in the reconstitution quality of the lyophilized standard sample 40. In this embodiment, the reconstitution solution is automatically dispensed by the reconstitution solution dispensing mechanism 210, which effectively improves the consistency of the dispensing volume and the dispensing accuracy, thereby reducing the impact of the dispensing volume of the reconstitution solution on the measurement results of the liquid standard sample 50.

[0230] In one embodiment, the reconstitution apparatus 200 further includes a first transfer mechanism 250, which is used to transfer a standard sample container 20 containing at least a portion of a liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to a first container carrier 30. In this embodiment, by transferring the standard sample container 20 to the first container carrier 30 via the first transfer mechanism 250, the liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 can be automatically transferred to the first container carrier 30 without manual loading, thereby reducing the workload and operational burden on operators.

[0231] In one embodiment, the reconstitution apparatus 200 further includes a carrier scheduling mechanism 270, which is used to schedule a first container carrier 30, which is loaded with a standard sample container 20 and at least part of a liquid standard sample 50, from the reconstitution apparatus 200 to the transfer device 300. In this embodiment, the liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 is transferred to the first container carrier 30 by the first transfer mechanism 250 within the reconstitution device 200. Then, the first container carrier 30 carrying the liquid standard sample 50 is dispatched to the transmission device 300 by the carrier dispatching mechanism 270. In this way, on the one hand, since there is no need to set up other mechanisms outside the reconstitution device 200 to dispatch the liquid standard sample 50 formed by reconstitution in the reconstitution device 200 to the transmission device 300, it is beneficial for the reconstitution device 200 to form an independent and highly automated functional module. This allows the reconstitution device 200 to be quickly combined with the transmission device 300 and the sample determination device 10 to form a sample analysis device 10 that automatically reconstitutes the lyophilized standard sample 40 and automatically transports and determines it after reconstitution. On the other hand, since there is no need for manual dispatching of the liquid standard sample 50 formed by reconstitution in the reconstitution device 200 to the transmission device 300, it is beneficial to reduce the workload and burden of the operators.

[0232] In one embodiment, the sample analysis device 10 further includes a control device 400, which is used to control the operation of at least one of the reconstitution device 200, the sample determination device 100, and the transmission device 300, that is, the control device 400 is used to control at least one of the reconstitution device 200, the sample determination device 100, and the transmission device 300 to start, run, and stop.

[0233] In one implementation, the control device 400, together with the sample measuring device 100, the reconstitution device 200, and the transmission device 300, controls the operation of the sample measuring device 100, the reconstitution device 200, and the transmission device 300. That is, the sample measuring device 100, the reconstitution device 200, and the transmission device 300 are all controlled by the control device 400, which helps to ensure the automation and continuity of operation of the sample analysis equipment 10.

[0234] In one implementation, the control device 400 is electrically connected to the sample determination device 100, the reconstitution device 200, and the transmission device 300, respectively. In this embodiment, the control device 400 controls the sample determination device 100, the reconstitution device 200, and the transmission device 300 via a wired connection; however, in specific applications, as an alternative implementation, the control device 400 can also control the sample determination device 100, the reconstitution device 200, and the transmission device 300 via wireless communication.

[0235] As one implementation method, freeze-dried standard sample 40 is a solid standard sample prepared by vacuum freeze-drying. Vacuum freeze-drying is a freeze-drying technology that utilizes the principle of sublimation to dehydrate materials. Specifically, vacuum freeze-drying technology freezes water-containing materials into a solid state and utilizes the sublimation properties of water under low temperature and low pressure conditions to dehydrate the materials at low temperature, thus achieving freeze-drying. Because vacuum freeze-drying technology is carried out in a low-temperature, low-oxygen environment, most biological reactions are halted, and no liquid water is present during the process. Water sublimates directly in a solid state, maximizing the preservation of the original structure and shape of the material, ultimately obtaining high-quality freeze-dried products with both excellent appearance and internal quality.

[0236] In one implementation, the reconstitution device 200 is located outside the sample determination device 100, meaning that the reconstitution device 200 and the sample determination device 100 are two independent devices. In this embodiment, placing the reconstitution device 200 outside the sample determination device 100 ensures that its placement does not affect the structure and internal layout of the sample determination device 100. The reconstitution device 200 and the sample determination device 100 are assembled as two independent modules, and the reconstitution device 200 can be quickly removed or added as needed. Of course, in specific applications, as an alternative implementation, the reconstitution device 200 can also be located inside the sample determination device 100.

[0237] In one implementation, after the lyophilized standard sample 40 is reconstituted, it does not need to be aliquoted. The original standard sample container 20 used to hold the lyophilized standard sample 40 is directly used as the container for the liquid standard sample 50 and transferred from the reconstitution device 200 to the sample determination device 100. That is, the original container of the lyophilized standard sample 40 is used to transfer the liquid standard sample 50 to the sample determination device 100, which saves the time of aliquoting the liquid standard sample 50 and thus reduces the time required for standard sample items. Of course, in an alternative implementation, the lyophilized standard sample 40 can also be aliquoted into different containers after reconstitution.

[0238] In one embodiment, the reconstitution apparatus 200 further includes a carrier buffer mechanism 280, which is at least used to buffer the first container carrier 30 when it is in an empty state. The first transfer mechanism 250 transfers the standard sample container 20 containing at least a partially liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to the first container carrier 30, including: the first transfer mechanism 250 transferring the standard sample container 20 containing at least a partially liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to the first container carrier 30 from the carrier buffer mechanism 280. In this embodiment, by setting a carrier buffer mechanism 280 in the reconstitution device 200 to buffer the first container carrier 30 when it is in an empty state, when it is necessary to transfer at least a portion of the liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to the sample determination device 100 for determination, the standard sample container 20 containing at least a portion of the liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 can be quickly transferred to the first container carrier 30, without the need for manual or other mechanism to replenish the first container carrier 30 to the reconstitution device 200 from outside the reconstitution device 200, thereby reducing the time occupied by the liquid standard sample 50 determination item for the sample to be tested. Of course, in specific applications, it is not necessary to set up a carrier buffer mechanism 280 in the reconstitution device 200 to buffer the first container carrier 30 in an empty state. For example, as an alternative implementation, when it is necessary to transfer at least a portion of the liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to the sample measuring device 100 for measurement, the first container carrier 30 in an empty state can be transferred from outside the reconstitution device 200 to inside the reconstitution device 200 by other mechanisms, or the first container carrier 30 in an empty state can be placed into the reconstitution device 200 manually.

[0239] In one embodiment, the reconstitution apparatus 200 further includes a storage mechanism 230, which is at least used to store the standard sample container 20 containing the lyophilized standard sample 40. The reconstitution solution dispensing mechanism 210 performs a reconstitution solution dispensing action on the standard sample container 20 containing the lyophilized standard sample 40, including: the reconstitution solution dispensing mechanism 210 dispensing a reconstitution solution from the storage mechanism 230 into the standard sample container 20 containing the lyophilized standard sample 40. In this embodiment, by providing a storage mechanism 230 within the reconstitution apparatus 200 to store the standard sample container 20 containing the lyophilized standard sample 40, when it is necessary to determine the liquid standard sample 50, the lyophilized standard sample 40 can be quickly reconstituted to form the liquid standard sample 50, without the need for manual or other means to move the standard sample container 20 containing the lyophilized standard sample 40 from outside the reconstitution apparatus 200 to the reconstitution apparatus 200, thereby reducing the time required for the determination of the liquid standard sample 50. Of course, in specific applications, the storage mechanism 230 may not be provided in the reconstitution device 200. For example, as an alternative implementation, when it is necessary to measure the liquid standard sample 50, the standard sample container 20 containing the lyophilized standard sample 40 can be transferred from outside the reconstitution device 200 to inside the reconstitution device 200 through other mechanisms, or the standard sample container 20 containing the lyophilized standard sample 40 can be placed into the reconstitution device 200 manually.

[0240] In one embodiment, the storage mechanism 230 is also used to store the standard sample container 20 containing the liquid standard sample 50, that is: the storage mechanism 230 is used to store the standard sample container 20 containing the freeze-dried standard sample 40, and is also used to store the standard sample container 20 containing the liquid standard sample 50.

[0241] In one embodiment, the carrier buffer mechanism 280 is also used to buffer a first container carrier 30 containing a standard sample container 20, which in turn contains a lyophilized standard sample 40. The first transfer mechanism 250 is also used to transfer the standard sample container 20 containing the lyophilized standard sample 40 from the first container carrier 30 of the carrier buffer mechanism 280 to the storage mechanism 230. In this embodiment, by configuring the carrier buffer mechanism 280 to buffer the first container carrier 30 containing the standard sample container 20 containing the lyophilized standard sample 40, it is advantageous for multiple first container carriers 30 containing the standard sample container 20 containing the lyophilized standard sample 40 to queue within the reconstitution apparatus 200 and wait for transfer to the storage mechanism 230, thereby facilitating continuous injection of batches of lyophilized standard samples 40.

[0242] In one implementation, the carrier buffer mechanism 280 includes at least two carrier buffer channels, each for buffering a single empty first container carrier 30 or a first container carrier 30 loaded with a standard sample container 20 containing a lyophilized standard sample 40. The carrier scheduling mechanism 270 moves to align with a carrier buffer channel to move an empty first container carrier 30 into that channel or to move a first container carrier 30 loaded with a standard sample container 20 out of that channel. In this embodiment, the carrier buffer mechanism 280 is configured as a channel structure, which facilitates the orderly placement of the first container carrier 30 within the reconstitution apparatus 20 and facilitates the carrier scheduling mechanism 270 in and out of the carrier buffer mechanism 280. Of course, in specific applications, the arrangement of the carrier buffer mechanism 280 is not limited to this; for example, as an alternative implementation, it can be configured as a buffer platform; or, the number of carrier buffer channels can be one.

[0243] In one implementation, the above-mentioned at least two vehicle buffer channels are arranged side by side along the first horizontal direction X3.

[0244] In one implementation, storage mechanism 230 is used to refrigerate and / or freeze the standard sample container 20 containing the lyophilized standard sample 40. Freezing provides a lower storage temperature than refrigeration. Both refrigeration and freezing provide a lower storage temperature, which helps maintain the shelf life of the lyophilized standard sample 40. The shelf life of the lyophilized standard sample 40 is longer when stored frozen than when refrigerated. Refrigeration allows the standard sample container 20 to be stored at refrigeration temperatures (above freezing). Freezing allows the standard sample container 20 to be stored at freezing temperatures (below freezing).

[0245] In one implementation, the storage mechanism 230 is also used to refrigerate and / or freeze the standard sample container 20 containing the liquid standard sample 50. The shelf life of the liquid standard sample 50 is longer when stored frozen than when stored refrigerated.

[0246] In one implementation, the storage mechanism 230 is used to refrigerate the standard sample container 20 containing the lyophilized standard sample 40 and the standard sample container 20 containing the liquid standard sample 50. In this embodiment, the storage mechanism 230 has a refrigeration function but no freezing function, which can meet the storage requirements of the lyophilized standard sample 40 and the liquid standard sample 50 in the reconstitution device 200, and also helps to reduce the power consumption of the reconstitution device 200. Of course, in specific applications, as an alternative implementation, the storage mechanism 230 can also be configured to have a freezing function but no refrigeration function; or, as another alternative implementation, the storage mechanism 230 can also be configured to have both freezing and refrigeration functions, with the refrigeration function used to refrigerate and store the standard sample container 20 containing the lyophilized standard sample 40, and the freezing function used to freeze and store the standard sample container 20 containing the liquid standard sample 50; or, both the standard sample container 20 containing the lyophilized standard sample 40 and the standard sample container 20 containing the liquid standard sample 50 can be stored both refrigeratedly and frozen.

[0247] In one embodiment, the reconstitution apparatus 200 further includes a rewarming mechanism 240, which is at least used to perform a rewarming treatment on the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230; the reconstitution dispensing mechanism 210 performs a reconstitution dispensing operation on the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230, including: the reconstitution dispensing mechanism 210 performs a reconstitution dispensing operation on the standard sample container 20 from the storage mechanism 230 after the rewarming treatment has been completed. To prevent the lyophilized standard sample 40 from deteriorating, the storage temperature of the storage mechanism 230 is set relatively low, for example, set to a refrigeration temperature or a freezing temperature. In this embodiment, after the freeze-dried standard sample 40 is stored in the storage mechanism 230, it is first heated by the reheating mechanism 240 before it is needed, so that the temperature of the freeze-dried standard sample 40 is restored to the preset range. This helps to ensure that the freeze-dried standard sample 40 can be effectively reconstituted, and also helps to avoid the temperature of the liquid standard sample 50 formed by the reconstitution of the freeze-dried standard sample 40 affecting the efficiency and results of the standard sample determination.

[0248] In one embodiment, the rewarming mechanism 240 is also used to perform a rewarming treatment on the standard sample container 20 containing the liquid standard sample 50 from the storage mechanism 230. In this embodiment, after the liquid standard sample 50 is stored in the storage mechanism 230, it is first heated by the rewarming mechanism 240 before use, so that the temperature of the liquid standard sample 50 is restored to a preset range, thereby helping to avoid the temperature of the liquid standard sample 50 affecting the efficiency and results of the standard sample determination.

[0249] In one implementation, the first transfer mechanism 250 is also used to transfer the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230 to the rewarming mechanism 240. In this embodiment, the storage mechanism 230 and the rewarming mechanism 240 are set up independently, and the first transfer mechanism 250 is required to transfer the standard sample container 20 between them. Of course, in specific applications, as an alternative implementation, the standard sample container 20 containing the lyophilized standard sample 40 can also be transferred from the storage mechanism 230 to the rewarming mechanism 240 through other mechanisms; or, the storage mechanism 230 and the rewarming mechanism 240 can also be integrated.

[0250] In one implementation, the rewarming mechanism 240 is located between the storage mechanism 230 and the carrier buffer mechanism 280 in the first horizontal direction X3. In this embodiment, the distance from the rewarming mechanism 240 to the storage mechanism 230 is set to be less than the distance from the carrier buffer mechanism 280 to the storage mechanism 230. This can shorten the travel distance of the first transfer mechanism 250 in transferring the standard sample container 20 between the storage mechanism 230 and the rewarming mechanism 240, thereby improving the transfer efficiency of the standard sample container 20 in the reconstitution device 200 and avoiding interference between the first transfer mechanism 250 and other mechanisms.

[0251] In one implementation, in the second horizontal direction X4, the rewarming mechanism 240 and the carrier buffer mechanism 280 are located on the side of the carrier scheduling mechanism 270 away from the sample measuring device 100, that is, the rewarming mechanism 240 and the carrier buffer mechanism 280 are located on the side of the carrier scheduling mechanism 270 facing away from the sample measuring device 100. In this embodiment, setting the distance from the carrier scheduling mechanism 270 to the sample measuring device 100 to be less than the distance from the rewarming mechanism 240 and the carrier buffer mechanism 280 to the sample measuring device 100 can shorten the travel distance of the carrier scheduling mechanism 270 in scheduling the first container carrier 30 to the transmission device 300, thereby improving the scheduling efficiency of the first container carrier 30 between the remelting device 200 and the transmission device 300, and also helping to avoid interference between the carrier scheduling mechanism 270 and other mechanisms.

[0252] In one implementation, the first horizontal direction X3 and the second horizontal direction X4 are perpendicular to each other. Specifically, the first horizontal direction X3 and the second horizontal direction X4 are approximately perpendicular, allowing for a certain margin of error. For example, the first horizontal direction X3 and the second horizontal direction X4 have an angle of 85° to 95°.

[0253] In one embodiment, the reconstitution apparatus 200 further includes a mixing mechanism 220, which performs a mixing action on the standard sample container 20 after the reconstitution dispensing operation, to mix the liquid standard sample 50 formed by the reconstitution of the lyophilized standard sample 40 within the standard sample container 20. A first transfer mechanism 250 transfers the standard sample container 20, containing at least a portion of the liquid standard sample 50 formed by the reconstitution of the lyophilized standard sample 40, to a first container carrier 30 from the carrier buffer mechanism 280, including: the first transfer mechanism 250 transferring the standard sample container 20 after the mixing operation to the first container carrier 30 from the carrier buffer mechanism 280. The mixing operation of the mixing mechanism 220 can accelerate the dissolution of the lyophilized standard sample 40 and promote its uniform concentration distribution, thereby facilitating faster reconstitution of the lyophilized standard sample 40 and ensuring sufficient and efficient reconstitution.

[0254] In one embodiment, the mixing mechanism 220 mixes the liquid in the standard sample container 20 by at least one of the following methods: shaking mixing, vibration mixing, stirring mixing, ultrasonic mixing, suction and expulsion mixing, and blowing bubbles mixing.

[0255] In one implementation, the mixing mechanism 220 and the rewarming mechanism 240 are separately configured, meaning they are independently configured. The first transfer mechanism 250 is also used to transfer the standard sample container 20, after the reconstitution solution dispensing operation, to the mixing mechanism 220. Of course, in specific applications, as an alternative implementation, the mixing mechanism 220 can also be integrated with the rewarming mechanism 240, meaning they are integrated. In this case, the mixing mechanism 220 can mix the liquid in the standard sample container 20 by at least one of the following methods: shaking, vibration, ultrasonic mixing, and bubble blowing.

[0256] In one implementation, the mixing mechanism 220 and the reconstitution dispensing mechanism 210 are separately configured, meaning they are independently configured. However, in specific applications, as an alternative implementation, the mixing mechanism 220 can also be integrated with the reconstitution dispensing mechanism 210, meaning they are integrated as one unit. For example, the mixing mechanism 220 can use the reconstitution dispensing mechanism 210 to perform aspiration and dispensing mixing operations on the liquid in the standard sample container 20.

[0257] In one implementation, the mixing mechanism 220 and the first transfer mechanism 250 are separately configured, meaning they are independently configured. However, in a specific application, as an alternative implementation, the mixing mechanism 220 can also be integrated with the first transfer mechanism 250, meaning they are integrated as one unit. In this case, the mixing mechanism 220 can mix the liquid in the standard sample container 20 using at least one of the following methods: shaking, vibration, ultrasonic mixing, stirring, or bubble blowing.

[0258] In one embodiment, the mixing mechanism 220 is located between the reheating mechanism 240 and the storage mechanism 230 in the first horizontal direction X3. In this embodiment, the mixing mechanism 220 is arranged in the space between the reheating mechanism 240 and the storage mechanism 230, which is beneficial to improve the structural compactness of the reconstitution device 200 and to ensure that the mixing mechanism 220 is within the stroke range of the first transfer mechanism 250 when transferring the standard sample container 20.

[0259] In one embodiment, the mixing mechanism 220 includes a mixing seat 221 and a mixing power assembly 222. The first transfer mechanism 250 is further used to transfer the standard sample container 20, which has undergone the reconstitution dispensing operation and contains at least a portion of the liquid standard sample 50 formed by the reconstitution of the lyophilized standard sample 40, to the mixing seat 221. The mixing power assembly 222 performs a mixing operation on the standard sample container 20 placed in the mixing seat 221 by at least one of the following methods: driving the mixing seat 221 to rotate, driving the mixing seat 221 to vibrate, performing suction and discharge operations on the liquid standard sample 50 placed in the standard sample container 20 in the mixing seat 221, blowing air into the liquid standard sample 50 placed in the standard sample container 20 in the mixing seat 221, performing a stirring operation on the liquid standard sample 50 placed in the standard sample container 20 in the mixing seat 221, and performing an ultrasonic mixing operation on the liquid standard sample 50 placed in the standard sample container 20 in the mixing seat 221. In this embodiment, the mixing mechanism 220 is set independently of the reheating mechanism 240, the reheat solution dispensing mechanism 210, and the first transfer mechanism 250. This allows the mixing action to be performed in parallel with the reheat solution dispensing, reheating, and transfer actions, which helps to ensure the working efficiency of the reconstitution device 200.

[0260] In one embodiment, the mixing seat 221 includes a first clamping seat 2211, a second clamping seat 2212, and a first elastic member 2213. The first clamping seat 2211 has a first groove, and the second clamping seat 2212 has a second groove. The first clamping seat 2211 and the second clamping seat 2212 are spliced ​​together and rotatably connected with the first groove and the second groove facing each other, so that the first groove and the second groove enclose each other to form a receiving cavity. The receiving cavity is used for at least partial insertion and positioning of the standard sample container 20. The two ends of the first elastic member 2213 are respectively connected to the first clamping seat 2211 and the second clamping seat 2212 so that the first groove and the second groove tend to move closer to each other. In a specific application, the first transfer mechanism 250 inserts the standard sample container 20 into the receiving cavity of the mixing mechanism 220 from top to bottom, and the first clamping seat 2211 and the second clamping seat 2212 are passively opened under the squeezing action of the standard sample container 20. After the standard sample container 20 is inserted into the mixing seat 221, the first clamping seat 2211 and the second clamping seat 2212 will clamp the standard sample container 20 under the pulling force of the first elastic member 2213 to prevent the standard sample container 20 from falling off the mixing seat 221 during the mixing action.

[0261] In one embodiment, the mixing seat 221 further includes a fixed seat 2214 and a first connecting shaft 2215, with the mixing power assembly 222 connected to the fixed seat 2214. The first connecting shaft 2215 is fixed to the fixed seat 2214, and one end of the first clamping seat 2211 and one end of the second clamping seat 2212 are rotatably connected to the first connecting shaft 2215. The first elastic member 2213 can cause the ends of the first clamping seat 2211 and the second clamping seat 2212 away from the first connecting shaft 2215 to tend to move closer together. Of course, in specific applications, the first connecting shaft 2215 can also be integrated into one of the fixed seat 2214, the first clamping seat 2211, and the second clamping seat 2212. For example, one of the first clamping seat 2211 and the second clamping seat 2212 is provided with the first connecting shaft 2215, and the other is provided with a first connecting hole that mates with the first connecting shaft 2215.

[0262] In one embodiment, the accommodating cavity has an opening away from the first connecting shaft 2215. The first connecting shaft 2215 is disposed near the bottom of the mixing seat 221, the opening is located at the top of the mixing seat 221, and the first elastic member 2213 is located between the first connecting shaft 2215 and the opening of the accommodating cavity.

[0263] In one implementation, the mixing power assembly 222 is used to drive the mixing seat 221 to rotate. Specifically, the mixing power assembly 222 is used to drive the fixed seat 2214 to rotate the first connecting shaft 2215, the first clamping seat 2211, the second clamping seat 2212 and the first elastic member 2213.

[0264] In one implementation, the mixing power assembly 222 is used to drive the mixing seat 221 to rotate 360°. Of course, in specific applications, the angle at which the mixing power assembly 222 drives the mixing seat 221 to rotate is not limited to this.

[0265] In one embodiment, the mixing power assembly 222 includes a first motor 2221 and a first transmission component 2222. The first transmission component 2222 is connected between the first motor 2221 and the mixing seat 221 to drive the mixing seat 221 to rotate under the drive of the first motor 2221.

[0266] In one embodiment, the first transmission component 2222 includes a belt drive component, which includes a driving pulley, a driven pulley, and a transmission belt, with the transmission belt wound around the driving pulley and the driven pulley. Of course, in specific applications, the arrangement of the first transmission component 2222 is not limited to this; for example, the first transmission component 2222 may also be configured to include a gear drive component and / or a chain drive component.

[0267] In one embodiment, the reheating mechanism 240 has a reheat solution dispensing position 242 and a plurality of receiving positions 241. The first transfer mechanism 250 is further configured to transfer the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230 to the receiving position 241; the rewarming mechanism 240 performs a rewarming process on the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230, including: the rewarming mechanism 240 performs a rewarming process on the standard sample container 20 transferred from the storage mechanism 230 to the receiving position 241 by the first transfer mechanism 250; the first transfer mechanism 250 is further configured to transfer the standard sample container 20 after the rewarming process from the receiving position 241 to the reconstitution dispensing position 242; the reconstitution dispensing mechanism 210 performs a reconstitution dispensing action on the standard sample container 20 after the rewarming process from the storage mechanism 230, including: the reconstitution dispensing mechanism 210 performs a reconstitution dispensing action on the standard sample container 20 transferred from the receiving position 241 to the reconstitution dispensing position 242 by the first transfer mechanism 250. The multiple accommodating positions 241 specifically refer to a minimum of two accommodating positions 241. In this embodiment, providing multiple accommodating positions 241 in the rewarming mechanism 240 facilitates the parallel rewarming of multiple standard sample containers 20 containing lyophilized standard samples 40 within the rewarming mechanism 240. Furthermore, forming the reconstitution dispensing position 242 on the rewarming mechanism 240 eliminates the need for a separate additional component for the reconstitution dispensing position 242, thereby reducing the number of components in the reconstitution device 200 and improving structural compactness. Of course, in specific applications, as an alternative implementation, the number of accommodating positions 241 can also be one; the reconstitution dispensing position 242 may also not be provided on the rewarming mechanism 240.

[0268] In one implementation, the solution dispensing position 242 is a first receiving hole formed on the reheating mechanism 240.

[0269] In one embodiment, the receiving position 241 is a second receiving hole formed on the reheating mechanism 240.

[0270] In one implementation, the rewarming mechanism 240 performs a rewarming process on the standard sample container 20 transferred from the storage mechanism 230 to the receiving position 241 by the first transfer mechanism 250. This includes: allowing the standard sample container 20 transferred from the storage mechanism 230 to the receiving position 241 by the first transfer mechanism 250 to naturally warm up in the natural temperature environment within the reconstitution device 200. That is, the rewarming mechanism 240 does not have a heating element, which helps to reduce power consumption. Of course, in specific applications, as an alternative implementation, the rewarming mechanism 240 may also include a heating element for heating the standard sample container 20 transferred from the storage mechanism 230 to the receiving position 241 by the first transfer mechanism 250.

[0271] In one implementation, the first transfer mechanism 250 is further used to transfer the standard sample container 20, after the reconstitution solution dispensing operation, from the reconstitution solution dispensing position 242 to the receiving position 241, so that the standard sample container 20 can undergo a first settling treatment at the receiving position 241; the first transfer mechanism 250 is also used to transfer the standard sample container 20, after the first settling treatment, from the receiving position 241 to the mixing mechanism 220. The first settling treatment is to let the standard sample container stand for a period of time. The first settling treatment is mainly used to dissolve the lyophilized standard sample 40 in the standard sample container 20 under the action of the reconstitution solution. The receiving position 241 used for the first settling treatment of the same standard sample container 20 and the receiving position 241 used for the rewarming treatment can be the same receiving position 241 or different receiving positions 241. In this embodiment, the first settling process is performed at the receiving position 241 on the reheating mechanism 240. That is, the first settling process is performed on the reheating mechanism 240 itself, eliminating the need for an additional first settling position. This reduces the number of components in the remelting device 200 and improves structural compactness. Of course, in specific applications, as an alternative implementation, the first settling process may not be performed at the receiving position 241 of the reheating mechanism 240.

[0272] As one implementation method, the reconstitution solution is one of pure water, deionized water, or distilled water, which is low in cost and does not cause a chemical reaction with the standard sample. Of course, in specific applications, the method of setting up the reconstitution solution is not limited to these.

[0273] In one implementation, the first transfer mechanism 250 is further used to transfer the standard sample container 20, after the mixing action is completed, from the mixing mechanism 220 to the receiving position 241, so that the standard sample container 20 can undergo a second settling treatment at the receiving position 241; the first transfer mechanism 250 transfers the standard sample container 20, after the mixing action is completed, to the first container carrier 30 from the carrier buffer mechanism 280, including: the first transfer mechanism 250 transfers the standard sample container 20, after the second settling treatment, from the receiving position 241 to the first container carrier 30 from the carrier buffer mechanism 280. The second settling treatment is mainly used to dissolve air bubbles in the liquid standard sample 50. The receiving position 241 used for the second settling treatment of the same standard sample container 20, the receiving position 241 used for the reheating treatment, and the receiving position 241 used for the first settling treatment can be the same receiving position 241, or at least the two can be different receiving positions 241. In this embodiment, the second settling process is performed at the receiving position 241 on the reheating mechanism 240. That is, the second settling process is performed on the reheating mechanism 240 itself, eliminating the need for an additional second settling position. This reduces the number of components in the remelting device 200 and improves structural compactness. Of course, in specific applications, as an alternative implementation, the second settling process may not be performed at the receiving position 241 of the reheating mechanism 240.

[0274] In one implementation, the duration of the first settling process is different from the duration of the second settling process.

[0275] In one embodiment, the reconstitution apparatus 200 further includes a cleaning mechanism 205, which is used to clean the reconstitution dispensing mechanism 210 after the reconstitution dispensing operation is completed. The reconstitution dispensing mechanism 210 includes a pipette. When performing the reconstitution dispensing operation, the pipette may be contaminated by the lyophilized standard sample 40. Therefore, performing a cleaning operation after completing the reconstitution dispensing operation of a standard sample container 20 can help reduce contamination.

[0276] In one embodiment, in the first horizontal direction X3, the cleaning mechanism 205 is located between the storage mechanism 230 and the reheating mechanism 240.

[0277] In one embodiment, a first unloading position 208 is formed within the reconstitution apparatus 200; the carrier scheduling mechanism 270 is further configured to schedule the standard sample container 20, which contains a standard sample container 20 and a freeze-dried standard sample 40, from the carrier buffer mechanism 280 to the first unloading position 208; the first transfer mechanism 250 transfers the standard sample container 20 containing the freeze-dried standard sample 40 from the first container carrier 30 from the carrier buffer mechanism 280 to the storage mechanism 230, including: the first transfer mechanism 250 transferring the standard sample container 20 containing the freeze-dried standard sample 40 from the first container carrier 30 scheduled to the first unloading position 208 by the carrier scheduling mechanism 270 to the storage mechanism 230; the carrier scheduling mechanism 270 is further configured to schedule the first container carrier 30, which is in an empty state after the standard sample container 20 has been transferred by the first transfer mechanism 250, from the first unloading position 208 to the carrier buffer mechanism 280.

[0278] In one implementation, the first unloading position 208 is located between the rewarming mechanism 240 and the vehicle buffer mechanism 280 in the first horizontal direction X3. This helps to reduce the travel distance of the first transfer mechanism 250.

[0279] In one embodiment, the reconstitution apparatus 200 further includes a first loading position 207; the carrier scheduling mechanism 270 is further configured to schedule the first container carrier 30, which is in an unloaded state, from the carrier buffer mechanism 280 to the first loading position 207; the first transfer mechanism 250 transfers the standard sample container 20, which contains at least a partial liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40, to the first container carrier 30 from the carrier buffer mechanism 280, including: transferring the standard sample container 20 containing at least a partial liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to the first container carrier 30 from the carrier buffer mechanism 280. Container 20 is transferred to a first container carrier 30, which is scheduled to the first loading position 207 by the carrier scheduling mechanism 270; the carrier scheduling mechanism 270 schedules the first container carrier 30, which contains the standard sample container 20 and at least a portion of the liquid standard sample 50, from the reconstitution device 200 to the transfer device 300, including: the carrier scheduling mechanism 270 schedules the first container carrier 30, which contains the standard sample container 20 and at least a portion of the liquid standard sample 50, from the first loading position 207 to the transfer device 300.

[0280] In one implementation, the first loading position 207 and the first unloading position 208 are located in the same position, which helps to improve the structural compactness of the remelting device 200. Of course, in specific applications, as an alternative implementation, the first loading position 207 and the first unloading position 208 may also be located in different positions.

[0281] In one implementation, in the first horizontal direction X3, the first loading position 207 is located between the reheating mechanism 240 and the vehicle buffer mechanism 280.

[0282] In one embodiment, the reconstitution apparatus 200 further includes a feeding mechanism 260, which is used to place a first container carrier 30 containing a standard sample container 20 and a freeze-dried standard sample 40 to feed the freeze-dried standard sample 40, or to place the standard sample container 20 containing the freeze-dried standard sample 40 onto the first container carrier 30 located in the feeding mechanism 260 to feed the freeze-dried standard sample 40. A carrier scheduling mechanism 270 is further used to schedule the first container carrier 30 containing the standard sample container 20 and the freeze-dried standard sample 40 from the feeding mechanism 260 to the carrier buffer mechanism 280 or the first unloading position 208. In this embodiment, the freeze-dried standard sample 40 is fed into the reconstitution apparatus 200. Of course, in specific applications, as an alternative implementation, the freeze-dried standard sample 40 can also be loaded in other places and then transferred to the reconstitution device 200 for reconstitution by the transfer mechanism. In this alternative implementation, the transfer device 300 is also used to transfer the first container carrier 30, which is loaded with the standard sample container 20 and the standard sample container 20 is loaded with the freeze-dried standard sample 40, to the reconstitution device 200; the carrier scheduling mechanism 270 is also used to schedule the first container carrier 30, which is loaded with the standard sample container 20 and the standard sample container 20 is loaded with the freeze-dried standard sample 40, from the transfer device 300 to the carrier buffer mechanism 280 or the first unloading position 208.

[0283] In one implementation, the feeding mechanism 260 is located above the carrier buffer mechanism 280, which helps to reduce the horizontal dimensions of the remelting device 200, thereby reducing the area occupied by the remelting device 200.

[0284] In one implementation, the feeding mechanism 260 is also used to place a first container carrier 30 containing a standard sample container 20 and a liquid standard sample 50 to achieve the feeding of the liquid standard sample 50; or the feeding mechanism 260 is also used to place a standard sample container 20 containing the liquid standard sample 50 on the first container carrier 30 located in the feeding mechanism 260 to achieve the feeding of the liquid standard sample 50. In this embodiment, the feeding mechanism 260 can feed both the freeze-dried standard sample 40 and the liquid standard sample 50. Of course, in specific applications, as an alternative implementation, the liquid standard sample 50 can also be fed in other places and then transferred to the reconstitution device 200 by a transfer mechanism.

[0285] In one embodiment, the reconstitution apparatus 200 further includes a first information acquisition component 201, which acquires information about a first identification code on the standard sample container 20 before the standard sample container 20 is transferred to the storage mechanism 230 by the first transfer mechanism 250. The control device 400 performs an information entry operation on the standard sample container 20 and / or the lyophilized standard sample 40 within the standard sample container 20 based on the information fed back by the first information acquisition component 201.

[0286] In one implementation, in the first horizontal direction X3, the first information acquisition component 201 is located between the storage mechanism 230 and the reheating mechanism 240.

[0287] In one implementation, the first information acquisition component 201 and the mixing mechanism 220 are arranged side by side in the second horizontal direction X4.

[0288] In one implementation, in the first horizontal direction X3, the cleaning mechanism 205 is located between the storage mechanism 230 and the first information acquisition component 201.

[0289] In one embodiment, the resolution apparatus 200 further includes a second information acquisition component 202, which is used to acquire information about the second identification code on the first container carrier 30.

[0290] In one implementation, the control device 400 confirms the first container carrier 30 based on the information fed back by the second information acquisition component 202.

[0291] In one implementation, the second information acquisition component 202 is used to acquire information about the second identification code on the first container carrier 30 located at the first unloading position 208 or the first loading position 207.

[0292] In one implementation, the second information acquisition component 202 is used to acquire information about the second identification code on the first container carrier 30 at at least the following times: before the first transfer mechanism 250 transfers the standard sample container 20 containing the freeze-dried standard sample 40 from the first container carrier 30 located at the first unloading position 208; before the first transfer mechanism 250 transfers the standard sample container 20 containing the liquid standard sample 50 from the storage mechanism 230 to the first container carrier 30 located at the first loading position 207; and before the first transfer mechanism 250 transfers the standard sample container 20 containing the liquid standard sample 50 from the first container carrier 30 located at the first unloading position 208.

[0293] As one implementation, before the first transfer mechanism 250 transfers the standard sample container 20 containing the freeze-dried standard sample 40 from the first container carrier 30 located at the first unloading position 208, the second information acquisition component 202 acquires information about the second identification code on the first container carrier 30 located at the first unloading position 208. On the one hand, it can confirm whether the container carrier located at the first unloading position 208 is the first container carrier 30; on the other hand, it can record the information of the first container carrier 30 to facilitate subsequent tracking of the location information and / or status information of the first container carrier 30.

[0294] In one implementation, before the first transfer mechanism 250 transfers the standard sample container 20 containing the liquid standard sample 50 from the storage mechanism 230 to the first container carrier 30 located at the first loading position 207, the second information acquisition component 202 acquires information of the second identification code on the first container carrier 30 located at the first loading position 207. On the one hand, it can confirm whether the container carrier located at the first loading position 207 is an empty first container carrier 30; on the other hand, it can update the status information and / or position information of the first container carrier 30.

[0295] In one implementation, before the first transfer mechanism 250 transfers the standard sample container 20 containing the liquid standard sample 50 from the first container carrier 30 located at the first unloading position 208, the second information acquisition component 202 acquires information about the second identification code on the first container carrier 30 located at the first unloading position 208. On the one hand, it can confirm whether the container carrier located at the first loading position 207 is the first container carrier 30; on the other hand, it can record or update the information of the first container carrier 30 to facilitate tracking the position information and / or status information of the first container carrier 30.

[0296] In one embodiment, the end of the transmission device 300 away from the reconstitution device 200 is provided with an inlet 312, which is at least used for inputting a sample rack containing a sample container and a sample to be tested.

[0297] In one embodiment, the sample determination device 100 includes a sample storage mechanism 110, which includes a loading area 111 and an unloading area 112. The sample analysis device 10 also includes a third information acquisition component 600, which is disposed beside or on the transmission device 300. The third information acquisition component 600 is used to acquire at least one of the following information: information about the sample rack or first container carrier 30 output from the unloading area 112 and transmitted by the transmission device 300 toward the inlet / outlet 312; information about the containers loaded on the sample rack or first container carrier 30 output from the unloading area 112 and transmitted by the transmission device 300 toward the inlet / outlet 312; and information about the containers loaded on the sample rack or first container carrier 30 output from the reconstitution device 200 and transmitted by the transmission device 300 toward the inlet / outlet 312.

[0298] In one implementation, based on feedback information from the third information acquisition unit 600, the type of sample rack or container on the first container carrier 30, which is output from the unloading area 112 and transported by the transmission device 300 toward the entrance / exit 312, is determined. Then, the transmission direction of the transmission device 300 is controlled to transport the standard sample container 20 and sample container output from the unloading area 112 to different areas for storage or recycling, facilitating the management of the standard sample container 20. When the standard sample container 20 output from the unloading area 112 is transferred to the reconstitution device 200 for storage or recycling, before the first transfer mechanism 250 transfers the standard sample container 20 containing the liquid standard sample 50 from the first container carrier 30 located at the first unloading position 208, the second information acquisition unit 202 acquires information from the second identification code on the first container carrier 30 located at the first unloading position 208 to perform secondary information confirmation on the first container carrier 30, ensuring the accuracy of container transmission scheduling. Of course, in specific applications, as an alternative implementation, the standard sample container 20 and the sample container output from the unloading area 112 can also be transferred to the same area for storage or recycling.

[0299] In one embodiment, the transfer device 300 includes a transfer track 310 and a third transfer mechanism (not shown). The transfer track 310 is provided with an injection position 311. The transfer device 300 transfers a first container carrier 30, which is output from the reconstitution device 20 and loaded with a standard sample container 20 containing at least a portion of the liquid standard sample 50, to the sample determination device 100. This includes: the transfer track 310 transferring the first container carrier 30, which is output from the reconstitution device 20 and loaded with a standard sample container 20 containing at least a portion of the liquid standard sample 50, to the injection position 311; and the first transfer mechanism 250 transferring the first container carrier 30, which is loaded with a standard sample container 20 containing at least a portion of the liquid standard sample 50, from the injection position 311 to the sample determination device 100. The transport track 310 is mainly used to carry the first container carrier 30 output from the reconstitution device 200 to the sample injection position 311, and the third transfer mechanism is mainly used to transfer the first container carrier 30 at the sample injection position 311 to the sample determination device 100. Of course, in specific applications, as an alternative implementation, the third transfer mechanism may not be provided, and the first container carrier 30 may be directly transported to the sample determination device 100 by the transport track 310.

[0300] In one embodiment, the first container carrier 30 includes a first base, which is a first container rack. The first container rack has at least two first placement positions, each for placing a single standard sample container 20. In this embodiment, the transfer track 310 uses the first container rack as a carrier to transfer the standard sample container 20, and the third transfer mechanism uses the first container rack as a carrier to transfer the standard sample container 20. Alternatively, in specific applications, the first base can also be a first container seat, which has a single second placement position for placing a single standard sample container 20. The transfer device 300 uses the first container seat as a carrier to transfer and / or transfer the standard sample container 20. The first container seat has only one second placement position, and one first container seat can only transfer one standard sample container 20 at a time.

[0301] In one implementation, the third transfer mechanism is a pusher mechanism for pushing the first container holder from the sample inlet 311 to the sample measuring device 100. Of course, in specific applications, the arrangement of the third transfer mechanism is not limited to this; for example, it can also be transferred by a robotic arm or by a track.

[0302] In one implementation, the reconstitution device 200 and the transfer track 310 are respectively distributed on adjacent sides of the sample determination device 100, so as to facilitate the transfer track 310 to transfer the first container carrier 30 loaded with the standard sample container 20.

[0303] Reference Figure 5 and Figure 6 As shown, in one embodiment, the sample determination device 100 includes a sample storage mechanism 110, which includes a loading area 111 and an unloading area 112. The loading area 111 and the unloading area 112 are spaced apart along the transfer track 310, and are respectively located near the two ends of the transfer track 310. The reconstitution device 200 is located near either the unloading area 112 or the loading area 111. The sample inlet 311 is located on the transfer track 310 directly opposite the loading area 111. An inlet / outlet 312 is formed at the end of the transfer track 310 away from the reconstitution device 200. The inlet / outlet 312 is at least used for inputting a sample rack containing a sample container and the sample to be tested. The transfer track 310 is used to: transfer the sample rack containing the sample container from the inlet / outlet 312 to the sample inlet 311 along a first transfer direction X1. The transfer track 310 is also used to: transfer the first container rack, which is output from the reconstitution device 200 and loaded with standard sample containers 20, towards the inlet / outlet 312 to the injection position 311 along the second transfer direction X2. The third transfer mechanism is used to transfer the first container rack located at the injection position 311 to the loading area 111, and to transfer the sample rack located at the injection position 311 to the loading area 111. The first transfer direction X1 and the second transfer direction X2 are two opposite directions. In this embodiment, the loading area 111 and the unloading area 112 are separately arranged, and the reconstitution device 200 is located close to the unloading area 112 or the loading area 111. The transfer track 310 is reused to transfer the sample rack loaded with sample containers to the injection position 311 and to transfer the first container rack loaded with standard sample containers 20 to the injection position 311. This facilitates the use of the existing track of the sample analysis device 10 as the transfer track 310, thereby simplifying the improvement cost of the sample analysis device 10.

[0304] Of course, in specific applications, the arrangement of the loading area 111 and the unloading area 112 is not limited to the above-mentioned arrangement where they are separately located at both ends of the transmission track 310. For example, referring to... Figure 7 and Figure 8As shown, in an alternative implementation, the loading area 111 and the unloading area 112 are arranged adjacently or integratedly, and are located near the same end of the transfer track 310; the sample inlet 311 is located directly opposite the loading area 111 to the transfer track 310; the reconstitution device 200 is located near one end of the transfer track 310, and an inlet / outlet 312 is formed at the end of the transfer track 310 away from the reconstitution device 200. The inlet / outlet 312 is at least used for inputting a sample holder containing a sample container and the sample to be tested; the transfer track 310 is used for: along a first transfer direction X1 transfers the sample rack containing sample containers from inlet / outlet 312 to injection station 311; the transfer track 310 is also used to: transfer the first container rack, which outputs from the reconstitution device 200 and contains standard sample containers 20, towards inlet / outlet 312 to injection station 311 along the second transfer direction X2; the third transfer mechanism is used to transfer the first container rack located at injection station 311 to loading area 111, and to transfer the sample rack located at injection station 311 to loading area 111; wherein the first transfer direction X1 and the second transfer direction X2 are two opposite directions. In this alternative embodiment, the reconstitution device 200 and loading area 111 and unloading area 112 can be located near the same end of the transfer track 310, or the reconstitution device 200 can be located near one end of the transfer track 310, and the loading area 111 and unloading area 112 can be located near the other end of the transfer track 310.

[0305] In one implementation, the first container rack and the sample rack are two identical container racks, meaning they are two container racks of the same shape and size. This allows the transfer track 310 to be reused for transferring the first container rack and the sample rack, the third transfer mechanism to be reused for transferring the first container rack and the sample rack, and the sample storage mechanism 110 to be reused for storing the first container rack and the sample rack. Of course, in specific applications, as an alternative implementation, the first container rack and the sample rack can also be two sample racks of different shapes and / or sizes.

[0306] As one implementation, the sample storage mechanism 110 is also used at least for unloading the samples to be tested. The sample container after aspiration can be dispatched by the sample dispatching mechanism 120 to the unloading area 112 of the sample storage mechanism 110 for removal and recycling by operators or robots, or transported by the transmission device 300 to other areas (such as the sample management device 500 described below) for recycling. The loading area 111 and the unloading area 112 can be set up separately and independently, or they can be integrated into one unit.

[0307] As one implementation, the sample storage mechanism 110 is also used at least for unloading the samples to be tested. The sample container after aspiration can be dispatched by the sample dispatching mechanism 120 to the unloading area 112 of the sample storage mechanism 110 for removal and recycling by operators or robots, or transported by the transmission device 300 to other areas (such as the sample management device 500 described below) for recycling. The loading area 111 and the unloading area 112 can be set up separately and independently, or they can be integrated into one unit.

[0308] In one implementation, sample containers are loaded, scheduled, and retrieved using sample racks. Operators or robots place a sample rack containing at least one sample container in the loading area 111 of the sample storage mechanism 110. Then, a sample scheduling mechanism 120 schedules the sample rack from the loading area 111 to the aspiration position for sample aspiration. Finally, the sample scheduling mechanism 120 schedules the sample rack, now aspirated, to the unloading area 112. Using sample racks for loading, scheduling, and retrieving sample containers allows the sample analysis equipment 10 to be used with sample containers of different sizes. It also facilitates batch loading and retrieval of samples and eliminates the need for operators to touch the sample containers, thus reducing the risk of infection. Of course, in specific applications, as an alternative implementation, sample containers can also be loaded, scheduled, and retrieved using sample holders.

[0309] As one implementation, the sample storage mechanism 110 is also used to buffer the sample containers. The sample storage mechanism 110 also includes a buffer area 113. The sample scheduling mechanism 120 is further used to: schedule sample racks loaded with samples to be tested to the buffer area 113 to queue for sample aspiration; schedule sample racks loaded with samples to be tested from the buffer area 113 to the second aspiration position for sample aspiration; schedule sample racks loaded with samples that need to be retested to the buffer area 113 to wait for re-sample aspiration and testing; and schedule sample racks loaded with samples that need to be retested to the aspiration position for sample aspiration. The buffer area 113 can be set up independently and separately from the loading area 111 and the unloading area 112, or it can be integrated with the loading area 111 and / or the unloading area 112.

[0310] In one embodiment, the sample determination device 100 further includes a sample scheduling mechanism 120 and a sample dispensing mechanism 130. The sample scheduling mechanism 120 is used to schedule a sample rack containing at least one sample container and the sample to be tested into the sampling position of the sample dispensing mechanism 130, and to schedule a first container rack containing at least one standard sample container 20 and the liquid standard sample 50 into the sampling position of the sample dispensing mechanism 130. In this embodiment, the liquid standard sample 50 and the sample to be tested are scheduled into the sampling position using the same container rack and the same sample scheduling mechanism 120, which simplifies the structure of the sample analysis device 10.

[0311] In one embodiment, the third information acquisition component 600 is disposed beside or on the transmission track 310. The third information acquisition component 600 is used to acquire information about the container rack (including sample rack and first container rack) output from the unloading area 112 and transported from the transmission track 310 toward the entrance / exit 312, or to acquire information about the containers loaded on the container rack output from the unloading area 112 and transported from the transmission track 310 toward the entrance / exit 312, or to acquire information about the container rack output from the unloading area 112 and transported from the transmission track 310 toward the entrance / exit 312. The control device 400 is further configured to: determine the type of liquid loaded in the containers on the container rack that are output from the unloading area 112 and transported by the transfer track 310 toward the inlet / outlet 312, or determine the type of containers on the container rack that are output from the unloading area 112 and transported by the transfer track 310 toward the inlet / outlet 312, or determine the type of container rack that is output from the unloading area 112 and transported by the transfer track 310 toward the inlet / outlet 312, based on the container rack information or container information fed back by the third information acquisition component 600; if it is determined that the liquid loaded in the containers on the container rack is... If the type of the substance is a test sample, or if the type of container loaded on the container rack is a sample container, or if the container rack is a sample rack, then the control transfer track 310 will transfer the container rack to the inlet / outlet 312 for recycling along the second transfer direction X2. If the type of liquid loaded in the container on the container rack is a liquid standard sample 50, or if the type of container loaded on the container rack is a standard sample container 20, or if the container rack is a first container rack, then the control transfer track 310 will transfer the sample rack to the reconstitution device 200 for storage or recycling along the first transfer direction X1. In this embodiment, based on the feedback information from the third information acquisition component 600, the type of container on the container rack output from the unloading area 112 and transferred by the transfer track 310 toward the inlet / outlet 312, or the type of container rack, or the type of liquid in the container on the container rack, is determined. Then, the transfer direction of the transfer track 310 is controlled to transfer the standard sample container 20 and the sample container output from the unloading area 112 to different areas for storage or recycling, so as to facilitate the management and reuse of the standard sample container 20. Of course, in specific applications, as an alternative implementation, the standard sample container 20 and the sample container output from the unloading area 112 can also be transferred to the same area for storage or recycling.

[0312] In one implementation, the third information acquisition component 600 includes at least one of a vision camera, a barcode scanner, a QR code scanner, and a radio frequency barcode reader. The first information acquisition component 201 and the second information acquisition component 202 may also be configured to include at least one of a vision camera, a barcode scanner, a QR code scanner, and a radio frequency barcode reader.

[0313] In one embodiment, the reconstitution apparatus 200 further includes a reconstitution buffer mechanism 290 for storing a second container carrier 60 containing a reconstitution container 70 and the reconstitution container 70 containing a reconstitution solution; the reconstitution dispensing mechanism 210 performs a reconstitution dispensing operation on a standard sample container 20 containing a lyophilized standard sample 40, including: the reconstitution dispensing mechanism 210 draws at least a portion of the reconstitution solution from the reconstitution container 70 loaded on the second container carrier 60 from the reconstitution buffer mechanism 290, and dispenses the drawn at least a portion of the reconstitution solution into the standard sample container 20 containing the lyophilized standard sample 40.

[0314] In one implementation, in the first horizontal direction X3, the reconstitution buffer mechanism 290 is located between the first unloading position 208 and the vehicle buffer mechanism 280.

[0315] In one implementation, the feeding mechanism 260 is also used to place the second container carrier 60, which contains the reconstituted solution container 70 and the reconstituted solution container 70 is filled with the reconstituted solution, to realize the feeding of the reconstituted solution, or to place the reconstituted solution container 70, which contains the reconstituted solution, on the second container carrier 60 located at the feeding mechanism 260 to realize the feeding of the reconstituted solution; the carrier scheduling mechanism 270 is also used to schedule the second container carrier 60, which contains the reconstituted solution container 70 and the reconstituted solution container 70 is filled with the reconstituted solution, from the feeding mechanism 260 to the reconstituted solution buffer mechanism 290. Alternatively, the conveying device 300 is also used to convey the second container carrier 60, which contains the reconstituted solution container 70 and the reconstituted solution container 70 is filled with the reconstituted solution, to the reconstituted solution buffer mechanism 290. The feeding method for the reconstituted solution can be referred to the freeze-dried standard sample 40, and will not be described in detail here.

[0316] In one embodiment, the vehicle scheduling mechanism 270 includes a carrier 271, an entry / exit drive assembly, and a spatial motion assembly 272. The carrier 271 forms a vehicle accommodating channel 2711. The first container carrier 30 has a first base whose width is adapted to the width of the vehicle accommodating channel 2711, and the second container carrier 60 has a second base 61 whose width is adapted to the width of the vehicle accommodating channel 2711. The entry / exit drive assembly is used to drive the first base to move in and out of the vehicle accommodating channel 2711 and to drive the second base 61 to move in and out of the vehicle accommodating channel 2711. The spatial motion assembly 272 is used to drive the carrier 271 and the entry / exit drive assembly to perform spatial motion, so that the vehicle accommodating channel 2711 is moved to a position that docks with the loading mechanism 260, a position that docks with the vehicle buffer mechanism 280, a position that docks with the first unloading position 208, a position that docks with the first loading position 207, and a position that docks with the transmission device 300, respectively. In this embodiment, the first container carrier 30 and the second container carrier 60 are configured with a width that is adapted to the width of the carrier accommodating channel 2711. This facilitates the reusable carrier scheduling mechanism 270 to schedule the first container carrier 30 and the second container carrier 60, thereby simplifying the structure of the remelting device 200.

[0317] In one embodiment, the first substrate is a first container rack having at least two first placement positions, each first placement position for placing a single standard sample container 20; or, the first substrate is a first container seat having a single second placement position for placing a single standard sample container 20.

[0318] In one embodiment, the first base is a first container frame, the width of the second base 61 is the same as the width of the first container frame, and the second container carrier 60 also includes a receiving seat 62, which is disposed on the top of the second base 61, and the top of the receiving seat 62 is provided with a cavity for at least part of the reconstituted solution container 70 to be placed and positioned.

[0319] In one embodiment, the reconstitution apparatus 200 further includes a storage mechanism 230 and a door 232 driving mechanism. The storage mechanism 230 is used to store the standard sample container 20 containing the lyophilized standard sample 40. The storage mechanism 230 includes a storage chamber 231 and a door 232. The storage chamber 231 is a refrigerated chamber or a frozen chamber. The storage chamber 231 has a chamber opening 2311 for the first transfer mechanism 250 to pick up and put in the standard sample container 20. The door 232 is disposed at the chamber opening 2311 for opening or closing the chamber opening 2311. The door 232 driving mechanism is used to drive the door 232 to move, so that the door 232 opens or closes the chamber opening 2311. The door 232 is movably disposed at the chamber opening 2311.

[0320] When it is necessary to take out or put in the standard sample container 20 in the storage chamber 231, the drive mechanism of the door 232 opens the door 232; when the taking out or putting in the standard sample container 20 in the storage chamber 231 is completed, the drive mechanism of the door 232 closes the door 232 to isolate the storage chamber 231 from the outside air circulation.

[0321] In one implementation, the door 232 drive mechanism and the first transfer mechanism 250 are the same mechanism, which facilitates the reuse of the first transfer mechanism 250 and simplifies the structure of the remelting device 200. Of course, in specific applications, as an alternative implementation, the door 232 drive mechanism and the first transfer mechanism 250 can also be two different mechanisms.

[0322] In one implementation, the door 232 can be movably connected to the opening 2311.

[0323] In one implementation, the door 232 can be slidably connected to the opening 2311. Alternatively, the door 232 can be rotatably connected to the opening 2311.

[0324] In one implementation, a door 232 is formed on the top of the storage compartment 231.

[0325] In one implementation, the reconstitution device 200 further includes a first display screen 203, which displays at least one of the following information: management information for the standard sample container 20, management information for the reconstitution solution container 70, management information for the lyophilized standard sample 40, management information for the liquid standard sample 50, management information for the reconstitution solution, management information for the first container carrier 30, and management information for the second container carrier 60. The first display screen 203 allows operators to intuitively access and record management information for consumables within the reconstitution device 200.

[0326] In one implementation, the control device 400 inputs or updates one of the following information based on the information fed back by the first information acquisition component 201 and the second information acquisition component 202: management information of the standard sample container 20, management information of the reconstituted solution container 70, management information of the freeze-dried standard sample 40, management information of the liquid standard sample 50, management information of the reconstituted solution, management information of the first container carrier 30, and management information of the second container carrier 60.

[0327] In one embodiment, the reconstitution apparatus 200 further includes a storage mechanism 230, a rewarming mechanism 240, a reconstitution solution buffer mechanism 290, and a carrier buffer mechanism 280; the storage mechanism 230 is used to store a standard sample container 20 containing a lyophilized standard sample 40; the rewarming mechanism 240 is used at least to perform a rewarming process on the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230; the carrier buffer mechanism 280 is used at least to buffer a first container carrier 30 in an empty state; and the reconstitution solution buffer mechanism 290 is used to store a second container carrier containing a reconstitution solution container 70 and the reconstitution solution container 70 containing a reconstitution solution. 60; The reconstitution apparatus 200 also includes a first loading position 207 and a first unloading position 208, which are located at the same position; the carrier scheduling mechanism 270, the reconstitution solution buffer mechanism 290, the first loading position 207, the rewarming mechanism 240, and the storage mechanism 230 are arranged sequentially along the first horizontal direction X3; in the second horizontal direction X4, the carrier scheduling mechanism 270, the reconstitution solution buffer mechanism 290, the first loading position 207, and the rewarming mechanism 240 are all located on the side of the carrier scheduling mechanism 270 away from the sample measuring device 100; wherein, the first horizontal direction X3 and the second horizontal direction X4 are perpendicular to each other. This embodiment optimizes the layout of the components within the reconstitution apparatus 200, thereby improving the structural compactness of the reconstitution apparatus 200, reducing its volume, and increasing its operating efficiency.

[0328] In one embodiment, the reconstitution apparatus 200 further includes a feeding mechanism 260, a storage mechanism 230, a rewarming mechanism 240, a reconstitution solution buffer mechanism 290, and a carrier buffer mechanism 280. The feeding mechanism 260 is used to place a first container carrier 30 containing a standard sample container 20 and a lyophilized standard sample 40 to feed the lyophilized standard sample 40, or the feeding mechanism 260 is used to place a standard sample container 20 containing the lyophilized standard sample 40 on the first container carrier 30 located in the feeding mechanism 260 to feed the lyophilized standard sample 40. The feeding mechanism 260 is also used to place a second container carrier 60 containing a reconstitution solution container 70 and a reconstitution solution to feed the reconstitution solution, or to place a reconstitution solution container 70 containing the reconstitution solution on the second container carrier 60 located in the feeding mechanism 260. The reconstitution device 200 includes a container carrier 60 for loading the reconstitution solution; a storage mechanism 230 for storing at least a standard sample container 20 containing lyophilized standard samples 40; a rewarming mechanism 240 for performing rewarming treatment on the standard sample container 20 containing lyophilized standard samples 40 from the storage mechanism 230; a container buffer mechanism 280 for buffering at least a first container carrier 30 in an empty state; a reconstitution solution buffer mechanism 290 for storing a second container carrier 60 containing a reconstitution solution container 70 and the reconstitution solution container 70 containing the reconstitution solution; a first layer and a second layer are formed within the reconstitution device 200, with the second layer located above and communicating with the first layer. The storage mechanism 230, the rewarming mechanism 240, the reconstitution solution buffer mechanism 290, and the container buffer mechanism 280 are distributed in the first layer, and the loading mechanism 260 is distributed in the second layer. In this embodiment, by arranging the components within the reconstitution device 200 in vertical layers, the horizontal dimensions and floor space of the reconstitution device 200 are reduced. Of course, in specific applications, as an alternative implementation, the feeding device may also be arranged on the same layer as at least one of the storage mechanism 230, the reheating mechanism 240, the reheat solution buffer mechanism 290, and the carrier buffer mechanism 280.

[0329] In one implementation, the first and second spaces are connected as one unit, meaning there is no partition separating them. Of course, in specific applications, as an alternative implementation, a partition can also be provided between the first and second spaces.

[0330] In one embodiment, a third space is formed within the reconstitution device 200, located below the first space. The first space is provided with a recovery port 206 communicating with the third space. The third space is used to place a recovery container, which is used to recover the standard sample container 20 discarded through the recovery port 206. The first transfer mechanism 250 is also used to transfer the standard sample container 20 that meets one of the following conditions to the recovery port 206 for disposal: the standard sample container 20 containing liquid standard sample 50 with insufficient remaining liquid standard sample 50, the standard sample container 20 containing liquid standard sample 50 with expired shelf life, or the standard sample container 20 containing lyophilized standard sample 40 with expired shelf life.

[0331] In one embodiment, the first transfer mechanism 250 includes a clamping assembly 251 and a horizontal drive assembly 252. The clamping assembly 251 is used to clamp or release the standard sample container 20, and the horizontal drive assembly 252 is connected to the clamping assembly 251 to drive the clamping assembly 251 to move horizontally. The reconstitution dispensing mechanism 210 includes a pipette used to dispense the reconstitution solution into the standard sample container 20 containing the lyophilized standard sample 40. The horizontal drive assembly 252 is also connected to the pipette to drive the pipette to move horizontally. In this embodiment, the reconstitution dispensing mechanism 210 and the first transfer mechanism 250 share the same horizontal drive assembly 252, which simplifies the structure of the reconstitution device 200. Of course, in specific applications, as an alternative embodiment, the reconstitution dispensing mechanism 210 and the first transfer mechanism 250 may not share the horizontal drive assembly 252.

[0332] In one implementation, the horizontal drive assembly 252 includes a two-dimensional drive assembly that can drive the clamping assembly 251 and the pipette to move in two mutually perpendicular directions.

[0333] In one embodiment, the clamping assembly 251 includes a mounting base 2511, a first clamping arm 2512, a second clamping arm 2513, a second elastic member 2514, a second motor 2515, and a second transmission component 2516. One end of the first clamping arm 2512 and one end of the second clamping arm 2513 are rotatably connected to the mounting base 2511. The two ends of the second elastic member 2514 are respectively connected to the first clamping arm 2512 and the second clamping arm 2513 so that the other ends of the first clamping arm 2512 and the other ends of the second clamping arm 2513 tend to approach each other. The second transmission component 2516 is disposed between the first clamping arm 2512 and the second clamping arm 2513. The second motor 2515 is mounted on the mounting base 2511. The first clamping arm 2512 is mounted on the mounting base 2511 and is connected to the second transmission component 2516 for driving the second transmission component 2516 to switch between a first state and a second state. In the first state, the distance between the other end of the first clamping arm 2512 and the other end of the second clamping arm 2513 is smaller than the distance between the other ends of the first clamping arm 2512 and the second clamping arm 2513 in the second state. The first clamping arm 2512 and the second clamping arm 2513 are used to clamp the standard sample container 20 when the second transmission component 2516 is in the first state, and the first clamping arm 2512 and the second clamping arm 2513 are used to release the standard sample container 20 when the second transmission component 2516 is in the second state. The working principle of the first clamping arm 2512, the second clamping arm 2513, and the second elastic element 2514 can be referred to the clamping and releasing principle of the first clamping seat 2211, the second clamping seat 2212, and the first elastic element 2213 in the mixing seat 221.

[0334] In one embodiment, the first transfer mechanism 250 further includes a first lifting drive assembly connected to the mounting base 2511 for driving the clamping assembly 251 to move vertically. A horizontal drive assembly 252 is connected to the first lifting drive assembly for driving the first lifting drive assembly to move the clamping assembly 251 horizontally. The reconstitution dispensing mechanism 210 further includes a second lifting drive assembly connected to the pipette for driving the pipette to move vertically. The horizontal drive assembly 252 is also connected to the second lifting drive assembly for driving the second lifting drive assembly to move the pipette horizontally.

[0335] In one implementation, the first lifting drive assembly and the second lifting drive assembly are two different lifting drive assemblies. This facilitates asynchronous lifting and lowering movements of the clamping assembly 251 and the pipette, preventing interference. Of course, in specific applications, as an alternative implementation, the first lifting drive assembly and the second lifting drive assembly can also be the same lifting drive assembly. In this case, the lifting drive assembly drives the clamping assembly 251 and the pipette to move in opposite directions; for example, one of the clamping assembly 251 and the pipette rises while the other falls.

[0336] In one embodiment, the second transmission component 2516 includes a cam component 2501.

[0337] In one embodiment, the cam component 2501 includes a first abutment 2502 and a second abutment 2503. In a first state, at least one of the first abutment 2502 and the second abutment 2503 abuts against both the first clamping arm 2512 and the second clamping arm 2513. In a second state, the first abutment 2502 abuts against the first clamping arm 2512 but not against the second clamping arm 2513, and the second abutment 2503 abuts against the second clamping arm 2513 but not against the first clamping arm 2512.

[0338] In one implementation, the second motor 2515 drives the second transmission component 2516 to rotate within a range of 90°. That is, the second motor 2515 drives the second transmission component 2516 to rotate 90° in one direction, which can switch between one of the first state and the second state; the second motor 2515 drives the second transmission component 2516 to rotate 90° in the opposite direction, which can switch between the first state and the second state.

[0339] In one implementation, the first abutting member 2502 and the second abutting member 2503 are rotatable bearings or rotatable rollers, or a combination of bearings and rollers, which helps to reduce frictional resistance.

[0340] In one embodiment, the clamping assembly 251 further includes a third elastic member 2517. One end of the third elastic member 2517 is connected to one of the first clamping arm 2512 and the second clamping arm 2513, and the other end of the third elastic member 2517 is connected to the mounting base 2511. The third elastic member 2517 is mainly used to prevent the first clamping arm 2512 and the second clamping arm 2513 from rotating relative to the mounting base 2511.

[0341] In one embodiment, the clamping assembly 251 further includes a second connecting shaft 2518, which is fixed to the mounting base 2511. One end of the first clamping arm 2512 and one end of the second clamping arm 2513 are rotatably connected to the second connecting shaft 2518. The second elastic member 2514 can cause the ends of the first clamping arm 2512 and the second clamping arm 2513 away from the second connecting shaft 2518 to tend to move closer together. Of course, in specific applications, the second connecting shaft 2518 can also be integrated into one of the mounting base 2511, the first clamping arm 2512, and the second clamping arm 2513. For example, one of the first clamping arm 2512 and the second clamping arm 2513 is provided with the second connecting shaft 2518, and the other is provided with a second connecting hole that mates with the second connecting shaft 2518.

[0342] In one embodiment, the second connecting shaft 2518 is disposed near the top of the first clamping arm 2512 and the second clamping arm 2513, and the second elastic member 2514 is located between the second connecting shaft 2518 and the bottom of the first clamping arm 2512 and the second clamping arm 2513.

[0343] Specifically, the first clamping arm 2512 and the second clamping arm 2513 share a common pivot with the second connecting shaft 2518, and can perform opening or closing movements around the second connecting shaft 2518.

[0344] In one implementation, when the second motor 2515 drives the second transmission component 2516 to rotate from 0° to 90°, it opens the first clamping arm 2512 and the second clamping arm 2513, thereby opening the first clamping arm 2512 and the second clamping arm 2513. When the second motor 2515 drives the second transmission component 2516 to rotate back from 90° to 0°, under the pulling force of the second elastic element 2514, the first clamping arm 2512 and the second clamping arm 2513 close, thereby closing the first clamping arm 2512 and the second clamping arm 2513.

[0345] In one embodiment, the reconstitution apparatus 200 further includes a first housing 204, within which the reconstitution dispensing mechanism 210, the first transfer mechanism 250, and the carrier scheduling mechanism 270 are all located. The transmission device 300 includes a transmission track 310, outside which the transmission track 310 and the sample determination device 100 are located, and the first housing 204 has an output port directly opposite one end of the transmission track 310. The carrier scheduling mechanism 270 is used to schedule a first container carrier 30, containing a standard sample container 20 and at least a portion of a liquid standard sample 50, to the transmission track 310 via the output port. The output port allows the first container carrier 30 to enter and exit the first housing 204.

[0346] In one embodiment, the sample measuring device 100 includes a second housing, with the reconstitution device 200 and the transfer device 300 both located outside the second housing, and the reconstitution device 200 and the transfer device 300 located on adjacent sides of the second housing.

[0347] In one embodiment, the standard sample container 20 includes a glass bottle body 21 and a sealing member 22. The glass bottle body 21 has an inner cavity and a bottle mouth. The inner cavity is used to contain a lyophilized standard sample 40 and a liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40. The bottle mouth communicates with the inner cavity to allow at least a portion of the liquid standard sample 50 to be drawn out of the inner cavity. The sealing member 22 is used to seal the bottle mouth and includes a stopper 2201 at least partially inserted into the bottle mouth and / or a cap 2202 at least partially fitted outside the bottle mouth. The reconstitution solution dispensing mechanism 210 includes a pipette with a puncture function. The pipette is used to puncture at least the stopper 2201 and / or the cap 2202 of the standard sample container 20 to at least partially penetrate into the standard sample container 20 and dispense the reconstitution solution into the standard sample container 20. In specific applications, the bottle mouth is used to allow at least a portion of the liquid standard sample 50 to be drawn out of the inner cavity. The sealing member 22 is used to seal the bottle mouth. The glass bottle 21 can block moisture and oxygen, thereby extending the shelf life of the freeze-dried standard sample 40. Furthermore, the size of the glass bottle 21 is ideal for high-density freeze-dried standard samples 40, making it a cost-effective packaging form for the freeze-dried standard sample 40. In this embodiment, the pipette is a puncture needle that can puncture the stopper 2201 and / or cap 2202 to aspirate liquid. The reconstituted liquid standard sample 50 loaded in the standard sample container 20 can be directly measured without removing the stopper 2201 and / or cap 2202 of the standard sample container 20. The liquid standard sample 50 is aspirated directly from the standard sample container 20 by puncturing the cap 2202 and stopper 2201, making the measurement of the standard sample more convenient and helping to reduce the contact between the liquid standard sample 50 and air, thus making the liquid standard sample 50 more stable.

[0348] In one embodiment, the stopper 2201 includes a stopper body and a stopper cap. The stopper body is inserted through the bottle mouth, and the stopper cap is connected to one end of the stopper body. The outer diameter of the stopper cap is larger than the inner diameter of the bottle mouth, and the stopper cap abuts against the top end face of the glass bottle body 21.

[0349] In one embodiment, the stopper includes a first extension and a second extension. The second extension is connected axially between the first extension and the stopper cap. The outer wall of the first extension has an venting groove extending axially along the stopper. During the freeze-drying process, the water in the standard sample undergoes a sublimation process, from freezing to vaporization and discharge. Specifically, in the initial stage of freeze-drying, the first extension is partially inserted into the bottle neck, and the stopper cap does not abut against the top end face of the glass bottle 21. During the freeze-drying process, the gas inside the glass bottle 21 is discharged from the venting groove to the outside of the glass bottle 21, and the gas pressure inside the glass bottle 21 gradually decreases. The stopper will gradually and automatically penetrate deeper into the bottle neck until the stopper cap abuts against the top end face of the glass bottle 21.

[0350] In one embodiment, the top wall of the bottle cap 2202 is provided with a through hole 2203, which is used to avoid the first pipette. When the first pipette draws liquid standard sample 50 from the standard sample container 20, the first pipette is aligned with the through hole 2203, and then the first pipette passes through the through hole 2203, piercing through the cap and body of the stopper 2201 to enter the glass bottle body 21 to draw liquid.

[0351] In one embodiment, the outer diameter of the glass bottle 21 is between 12mm and 13mm. This embodiment, by setting the outer diameter of the glass bottle 21 to between 12mm and 13mm, allows the standard sample container 20 to be suitable for the size of a sample rack or sample holder. After the lyophilized standard sample 40 is reconstituted in the standard sample container 20, it can be directly placed on the sample rack or sample holder for loading and testing. That is, no dispensing is required after reconstitution, thereby saving time in standard sample determination and improving the efficiency of standard sample determination.

[0352] In one embodiment, the height of the glass bottle 21 is greater than or equal to 30 mm.

[0353] In one implementation, the total height of the standard sample container 20 is greater than or equal to 40 mm.

[0354] As one implementation method, considering the freeze-drying process, the total height of the standard sample container 20 is less than the height of the sample container.

[0355] In one implementation, the control device 400 is configured to control the reconstitution device 200 to reconstitute the lyophilized standard sample 40 into a liquid standard sample 50. In this embodiment, under the control of the control device 400, the reconstitution device 200 automatically reconstitutes the lyophilized standard sample 40 into a liquid standard sample 50. The reconstitution process requires no manual intervention, which helps to reduce the burden on operators and minimizes the impact of human operation factors on the standard sample measurement results.

[0356] In one implementation, the control device 400 is further configured to: control the transmission device 300 to transmit the first container carrier 30, which contains the standard sample container 20 after being output from the sample determination device 100 and dispensed by the sample determination device 100 with liquid standard sample 50, to the reconstitution device 200 for storage or recovery. Specifically, the control device 400 is further configured to: after the control transmission device 300 transmits the standard sample container 20, which contains the liquid standard sample 50, from the reconstitution device 200 to the sample determination device 100, control the sample determination device 100 to dispense at least a portion of the liquid standard sample 50 from the standard sample container 20 into the first reaction vessel, and control the transmission device 300 to transmit the first container carrier 30, which contains the standard sample container 20 after being dispensed by the sample determination device 100 with liquid standard sample 50, from the sample determination device 100 to the reconstitution device 200 for storage or recovery. In this embodiment, the standard sample container 20 containing the liquid standard sample 50 is returned to the reconstitution device 200 for storage and recovery after the sample determination device 100 completes the standard sample determination, facilitating the unified management of the standard sample and its container. Of course, in specific applications, as an alternative embodiment, the standard sample container 20 containing the liquid standard sample 50 may be stored and / or recovered within the sample determination device 100 after the sample determination device 100 completes the standard sample determination, or it may be transferred to other areas or devices besides the reconstitution device 200 and the sample determination device 100 for storage and / or recovery.

[0357] In one embodiment, the reconstitution apparatus 200 further includes a storage mechanism 230, a rewarming mechanism 240, and a mixing mechanism 220. The control device 400 is configured to: when a first preset condition is met, control the first transfer mechanism 250 to transfer the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230 to the receiving position 241 of the rewarming mechanism 240 for rewarming treatment; control the first transfer mechanism 250 to transfer the standard sample container 20 after rewarming treatment from the receiving position 241 to the reconstitution solution dispensing position 242; and control the reconstitution solution dispensing mechanism 220... Ten standard sample containers 20 located at the reconstitution dispensing position 242 are subjected to reconstitution dispensing action; the first transfer mechanism 250 is controlled to transfer the standard sample containers 20 after the reconstitution dispensing action is completed from the reconstitution dispensing position 242 to the receiving position 241 for the first settling treatment; the first transfer mechanism 250 is controlled to transfer the standard sample containers 20 after the first settling treatment from the receiving position 241 to the mixing mechanism 220; the mixing mechanism 220 is controlled to perform a mixing action on the standard sample containers 20 after the first settling treatment; the first transfer mechanism 250 is controlled to perform a mixing action on the standard sample containers 20 after the first settling treatment. 50 transfers the standard sample container 20, after completing the mixing action, from the mixing mechanism 220 to the receiving position 241 to perform the second settling process; controls the first transfer mechanism 250 to transfer the standard sample container 20, after completing the second settling process, from the receiving position 241 to the first container carrier 30 located at the first loading position 207; controls the carrier scheduling mechanism 270 to schedule the first container carrier 30, which contains the standard sample container 20 and has completed the second settling process, from the first loading position 207 to the transmission device 300; controls the transmission device... 300 transfers a first container carrier 30, which is dispatched to it by the carrier dispatching mechanism 270 and loaded with a standard sample container 20, to the sample measuring device 100; controls the sample measuring device 100 to draw at least a portion of the liquid standard sample 50 loaded in the standard sample container 20 from the first container carrier 30 from the transfer device 300 and distribute it to the first reaction container; controls the sample measuring device 100 to measure the first reaction liquid in the first reaction container, which is at least made from the liquid standard sample 50 distributed to the first reaction container, to obtain reference test data.

[0358] In one implementation, lyophilized standard sample 40 is a lyophilized quality control sample, liquid standard sample 50 is a liquid quality control sample, and reference detection data is quality control data. Specifically, the lyophilized quality control sample is prepared from a liquid quality control sample of known concentration through a lyophilization process. The liquid quality control sample is used to perform the quality control measurements of the sample analysis device 10. By comparing the measured results of the liquid quality control sample in the sample analysis device 10 with the preset known results (i.e., target values) in the sample analysis device 10, it can be confirmed whether the sample analysis device 10 is in normal working order. Of course, in specific applications, lyophilized standard sample 40 is not limited to lyophilized quality control samples. For example, as an alternative implementation, lyophilized standard sample 40 is a lyophilized calibrator, liquid standard sample 50 is a liquid calibrator, and reference detection data is calibration data. The lyophilized calibrator is prepared from a liquid calibrator of known concentration through a lyophilization process. The liquid calibrator is used to calibrate the various sample measurement items of the sample analysis device 10.

[0359] In one embodiment, the control device 400 is further configured to: control the transmission device 300 to transmit the first container carrier 30, which is output from the sample determination device 100 and loaded with the standard sample container 20, toward the reconstitution device 200; control the carrier scheduling mechanism 270 to schedule the first container carrier 30, which is from the transmission device 300 and loaded with the standard sample container 20, to the first unloading position 208; and control the first transfer mechanism 250 to transfer the standard sample container 20 from the first container carrier 30, which has been scheduled to the first unloading position 208 by the carrier scheduling mechanism 270, to the storage mechanism 230 for storage or to the recycling port 206 for disposal.

[0360] In one implementation method, the freeze-dried standard sample 40 is a freeze-dried quality control product, and the reference test data is the quality control data; the sample analysis device 10 has at least one of the following first preset conditions: reaching the first preset time point of the first preset cycle, the cumulative running time of the sample analysis device 100 since the last quality control item measurement has reached the first preset time, the number of times the sample analysis device 100 continuously measures the sample to be tested has reached the first preset number, the cumulative number of times the sample analysis device 100 cumulatively measures the sample to be tested since the last quality control item measurement has reached the second preset number, the reagent container is replaced to supply reagents, and the information of the quality control item is obtained according to the instructions input by the operator through the human-machine interaction device.

[0361] In one implementation, the control device 400 is further configured to: when a first preset condition is met, the control transmission device 300 transmits the first container carrier 30 of the standard sample container 20, which is output from the reconstitution device 200 and contains liquid standard sample 50, to the sample determination device 100. That is, the control transmission device 300 transmitting the first container carrier 30 of the standard sample container 20, which is output from the reconstitution device 200 and contains at least a portion of liquid standard sample 50, to the sample determination device 100 includes: when the first preset condition is met, the control transmission device 300 transmits the first container carrier 30 of the standard sample container 20, which is output from the reconstitution device 200 and contains liquid standard sample 50, to the sample determination device 100. The first preset condition is a condition pre-stored in the sample analysis device 10 for triggering the control device 400 to automatically control the execution of the standard sample determination item. In this implementation, the control device 400 automatically triggers the execution of the standard sample determination item according to the pre-stored first preset condition, without the need for manual intervention, thus reducing the workload of the operator. Of course, in specific applications, as an alternative implementation method, the standard sample determination items can also be set to be manually triggered.

[0362] In one implementation, when the lyophilized standard sample 40 is a lyophilized quality control product and the reference test data is the quality control data, the sample analysis device 10 is pre-stored with at least one of the following first preset conditions: reaching a first preset time point of a first preset cycle; the cumulative operating time of the sample analysis device 100 since the last quality control item measurement reaches a first preset time; the number of times the sample analysis device 100 continuously measures the sample to be tested reaches a first preset number; the cumulative number of times the sample analysis device 100 cumulatively measures the sample to be tested since the last quality control item measurement reaches a second preset number; changing the reagent container to supply reagents; and obtaining information on the quality control item to be performed according to the instructions input by the operator through the human-machine interface device. The control device 400 is configured such that when any one or more of the first preset conditions are met, the control transmission device 300 transmits the standard sample container 20, which is output from the reconstitution device 200 and contains at least a portion of the liquid quality control product, to the sample analysis device 100. The sample analysis device 10 can store one or more first preset conditions. When there are two or more first preset conditions stored in the sample analysis device 10, the control device 400 controls the transmission device 300 to transfer the liquid standard sample 50 from the reconstitution device 200 to the sample determination device 100 when any of the first preset conditions is met, in order to perform the quality control item. In this embodiment, the execution of the quality control item will not occupy the sample determination cycle time, and it will be automatically executed according to the set program when the first preset condition is met. This makes the execution process of the quality control item virtually imperceptible to the operator, greatly reducing the interference of the quality control determination process on the operator.

[0363] In one implementation, the first preset period is daily. The first preset time point of the first preset period is 7:00 AM, 7:30 AM, 8:00 AM, 8:30 AM, 9:00 AM, or 9:30 AM daily. Of course, in specific applications, the setting of the first preset time point of the first preset period is not limited to this. It can be flexibly set according to the usage of the sample analysis equipment 10 in the specific application scenario. For example, it can also be two days, three days, four days, five days, six days, or one week.

[0364] As an alternative to the aforementioned lyophilized standard sample 40 as a lyophilized quality control sample, the lyophilized standard sample 40 is used as a lyophilized calibrator, with the reference test data serving as calibration data. The sample analysis device 10 has at least one of the following fourth preset conditions pre-stored: a second preset time interval since the last execution of the calibration process; a second preset time point in the second preset cycle; information about a newly loaded reagent container being obtained; information about an error in the quality control measurement result being obtained; and information about the calibration process being executed being obtained based on instructions input by the operator through the human-machine interface. The control device 400 is configured such that, when any one or more of the fourth preset conditions are met, the control transmission device 300 transmits the standard sample container 20, which is output from the reconstitution device 200 and contains at least a portion of the liquid calibrator, to the sample analysis device 100. The sample analysis device 10 can store one or more fourth preset conditions. When there are two or more fourth preset conditions stored in the sample analysis device 10, the control device 400 controls the transmission device 300 to transfer the liquid calibrator from the reconstitution device 200 to the sample measurement device 100 to perform the calibration. In this embodiment, the execution of the calibration will not occupy the sample measurement cycle time, and it will be automatically executed according to the set program when the fourth preset condition is met. This makes the operator virtually unaware of the calibration process and greatly reduces the interference of the calibration process on the operator.

[0365] In one embodiment, the control transfer device 300 transfers the standard sample container 20, which is output from the reconstitution device 200 and contains the liquid standard sample 50, to the sample determination device 100. This includes: when a first preset condition is met, the control transfer device 300 transfers the standard sample container 20, which is output from the reconstitution device 200 and contains the liquid standard sample 50, to the sample determination device 100. The control sample determination device 100 draws at least a portion of the liquid standard sample 50 contained in the standard sample container 20 and dispenses it into the first reaction vessel. This includes: the control sample determination device 100 draws at least a portion of the liquid standard sample 50 contained in the standard sample container 20 and dispenses it into the first reaction vessel; the control transfer device 300 transfers the standard sample container 20, which is output from the sample determination device 100 and has had at least a portion of the liquid standard sample 50 drawn and dispensed by the sample determination device 100, to the reconstitution device 200 for storage or recovery. The control device 400 is further configured to: after the control transmission device 300 transmits the standard sample container 20, which is output from the sample measuring device 100 and has been aspirated and dispensed by the sample measuring device 100 at least a portion of the liquid standard sample 50, to the reconstitution device 200 for storage, when the first preset condition is met again, determine whether the standard sample container 20, which is output from the sample measuring device 100 and has been aspirated and dispensed by the sample measuring device 100 at least a portion of the liquid standard sample 50, meets the second preset condition; if so, control the reconstitution device 200 to output the standard sample container 20 that meets the second preset condition to the transmission device 300, and control the transmission device 300 to transmit the standard sample container 20 that is output from the reconstitution device 200 and meets the second preset condition to the sample measuring device 100. In this implementation scheme, when the first preset condition is met and a standard sample determination item needs to be performed, the liquid standard sample 50 in the reconstitution device 200 is first checked to see if it meets the second preset condition. If the second preset condition is met, the liquid standard sample 50 is preferentially transferred to the sample determination device 100 for determination to avoid wasting the liquid standard sample 50. If the second preset condition is met, the lyophilized standard sample 40 needs to be reconstituted.

[0366] In one implementation, the second preset condition is that the volume of liquid standard sample 50 loaded in the standard sample container 20 is greater than or equal to the amount of liquid standard sample 50 required for a standard sample determination project (a quality control project or a calibration project). In this implementation, when the first preset condition is met and a standard sample determination project needs to be performed, the remaining amount of liquid standard sample 50 in the reconstitution device 200 is first checked. If the remaining amount is sufficient, the liquid standard sample 50 is preferentially transferred to the sample determination device 100 for determination to avoid waste of the liquid standard sample 50; if the remaining amount is insufficient, the lyophilized standard sample 40 needs to be reconstituted.

[0367] As an alternative implementation to the aforementioned second preset condition, the second preset condition is: the volume of liquid standard sample 50 loaded in the standard sample container 20 is greater than or equal to the required amount of liquid standard sample 50 for one standard sample determination project (one quality control project or one calibration project), and the liquid standard sample 50 in the standard sample container 20 is within its validity period. In this implementation, in addition to sufficient remaining quantity, the second preset condition also needs to meet the requirement of being within the validity period. Thus, in specific applications, when the first preset condition is met and a standard sample determination project needs to be performed, it is first checked whether the liquid standard sample 50 reconstituted and dispensed into the standard sample container 20 in the reconstitution device 20 is within its validity period and whether the remaining quantity is sufficient. If it is within its validity period and the remaining quantity is sufficient, the liquid standard sample 50 in the standard sample container 20 is preferentially transferred to the sample determination device 100 for determination; if it is past its validity period or the remaining quantity is insufficient, it is necessary to reconstitute and freeze-dry the standard sample 40 again.

[0368] In one embodiment, the controlled reconstitution device 200 reconstitutes the lyophilized standard sample 40 in the standard sample container 20 into a liquid standard sample 50. This includes: controlling the reconstitution solution dispensing mechanism 210 to dispense the reconstitution solution into the lyophilized standard sample 40 in the standard sample container 20, so that the lyophilized standard sample 40 and the reconstitution solution mix to form the liquid standard sample 50. The controlled transfer device 300 transfers the standard sample container 20, which is output from the sample determination device 100 and has been aspirated and dispensed by the sample determination device 100 with at least a portion of the liquid standard sample 50, to the reconstitution device 200 for storage or recovery. This includes: controlling the transfer device 300 to transfer the standard sample container 20, which is output from the sample determination device 100 and has been aspirated and dispensed by the sample determination device 100 with at least a portion of the liquid standard sample 50, to the storage mechanism 230 (refrigeration mechanism or freezing mechanism) for storage. The control device 400 is further configured to: before the control reconstitution device 200 outputs the standard sample container 20 that meets the second preset conditions to the transmission device 300, control the second transfer mechanism to transfer the standard sample container 20 that meets the second preset conditions from the storage mechanism 230 (refrigeration mechanism or freezing mechanism) to the rewarming mechanism 240 for heating treatment. In this embodiment, after the liquid standard sample 50 is stored in the refrigeration mechanism or freezing mechanism, it is first heated by the rewarming mechanism 240 before it is needed, so that the temperature of the liquid standard sample 50 is restored to the preset range, thereby helping to avoid the temperature of the liquid standard sample 50 affecting the efficiency and results of the standard sample determination.

[0369] In one embodiment, the sample measuring device 100 includes a sample measuring mechanism 140, a pipetting mechanism for drawing at least a portion of the liquid standard sample 50 contained in the standard sample container 20 located at the first aspiration position and dispensing it into the first reaction container; the sample measuring mechanism 140 is used to measure the first reaction solution in the first reaction container, which is at least made from the liquid standard sample 50 dispensed into the first reaction container.

[0370] In one embodiment, the sample measuring device 100 further includes a sample storage mechanism 110, a sample scheduling mechanism 120, and a sample dispensing mechanism 130. The sample storage mechanism 110 is used to store at least the sample to be tested; the sample scheduling mechanism 120 is used to schedule the sample to be tested from the sample storage mechanism 110 to the second sampling position; the sample dispensing mechanism 130 is used to draw the sample to be tested from the second sampling position and dispense it into the second reaction container; and the sample measuring mechanism 140 is used to measure the second reaction solution in the second reaction container, which is at least made from the sample to be tested.

[0371] In one implementation, the first reaction vessel and the second reaction vessel are two reaction vessels of the same shape and size. That is, the first reaction vessel and the second reaction vessel are two reaction vessels of the same specifications. Of course, in specific applications, the first reaction vessel and the second reaction vessel can also be two reaction vessels of different shapes and / or sizes.

[0372] In one embodiment, the sample determination device 100 further includes a reaction vessel supply mechanism 170, which has one container output channel for outputting a first reaction vessel and a second reaction vessel. A pipetting mechanism is used to aspirate at least a portion of the liquid standard sample 50 contained in the standard sample container 20 and dispense it into the first reaction vessel output from the container output channel. A sample dispensing mechanism 130 is used to aspirate at least a portion of the test sample contained in the sample container and dispense it into the second reaction vessel output from the container output channel. In this embodiment, the standard sample determination and the test sample determination share the same reaction vessel supply mechanism 170 to supply the reaction vessel, which simplifies the structure of the sample determination device 100. Of course, in specific applications, the standard sample determination and the test sample determination use different reaction vessel supply mechanisms 170 to supply the reaction vessels. For example, as an alternative embodiment, the sample determination device 100 includes two reaction vessel supply mechanisms 170, one for outputting the first reaction vessel and the other for outputting the second reaction vessel.

[0373] In one implementation, the sample measuring device 100 also includes a reaction vessel transfer mechanism 180, which is used to transfer the reaction vessel. The reaction vessel is a disposable container, meaning that after carrying the sample to be tested and completing the corresponding measurement, the reaction vessel is discarded and recycled without needing to be cleaned and reused within the sample analysis device 10, thus simplifying the structure and operating procedures of the sample analysis device 10. Of course, in specific applications, the reaction vessel can also be cleaned and recycled.

[0374] In one embodiment, the sample analysis device 10 further includes a sample management device 500, which and the reconstitution device 200 are located on opposite sides of the sample determination device 100, such as the left and right sides. One end of the transfer track 310 extends to the sample management device 500, and the other end extends to the reconstitution device 200. The inlet / outlet 312 is located at the end of the transfer track 310 near the sample management device 500. The sample management device 500 is used for loading sample containers containing samples to be tested and for storing sample containers after testing for later retrieval. A second sample rack containing samples to be tested is transported from the sample management device 500 to the transfer track 310 via the inlet / outlet 312, and a second sample rack output from the unloading area 112 is transported to the sample management device 500 via the inlet / outlet 312.

[0375] In one embodiment, the sample measuring device 100 further includes a reagent dispensing mechanism 150, which is used to draw reagents from a reagent container and dispense them into a first reaction container, and to draw reagents from a reagent container and dispense them into a second reaction container.

[0376] In one implementation, the sample dispensing mechanism 130 is reused to dispense the test sample and the liquid standard sample 50. The reagent dispensing mechanism 150 and the sample dispensing mechanism 130 are two independent mechanisms. Of course, in specific applications, as an alternative implementation, the dispensing mechanism of the liquid standard sample 50, the reagent dispensing mechanism 150, and the sample dispensing mechanism 130 can also be the same mechanism; or, the mechanism of the liquid standard sample 50, the reagent dispensing mechanism 150, and the sample dispensing mechanism 130 can also be three independent mechanisms; or, the mechanism of the liquid standard sample 50 and the reagent dispensing mechanism 150 can be the same mechanism, and the mechanism of the liquid standard sample 50 and the sample dispensing mechanism 130 can be two independent mechanisms. That is, in specific applications: the mechanism of the liquid standard sample 50 and the sample dispensing mechanism 130 can be the same mechanism or two independent mechanisms, and the mechanism of the liquid standard sample 50 and the reagent dispensing mechanism 150 can be the same mechanism or two independent mechanisms.

[0377] In the above scheme, the standard sample container 20, which outputs from the reconstitution device 200 and contains at least a portion of the liquid standard sample 50, is transferred to the sample storage mechanism 110 for storage. Of course, in specific applications, the standard sample container 20, which outputs from the reconstitution device 200 and contains at least a portion of the liquid standard sample 50, may not necessarily be transferred to the sample storage mechanism 110 for storage. For example, as an alternative implementation, the sample determination device 100 includes a sample storage mechanism 110, a sample scheduling mechanism 120, a sample dispensing mechanism 130, a reagent dispensing mechanism 150, a pipetting mechanism, and a sample determination mechanism 140; the sample storage mechanism 110 is used to store the sample container containing the sample to be tested; the sample scheduling mechanism 120 is used to schedule the sample container containing the sample to be tested from the sample storage mechanism 110 to the second aspiration position; the sample dispensing mechanism 130 is used to aspirate at least a portion of the sample to be tested contained in the sample container located at the second aspiration position and dispense it into the second reaction vessel. The transfer device 300 transfers a standard sample container 20, which is output from the reconstitution device 200 and contains at least a portion of the liquid standard sample 50, to a third aspiration position, which may be located at the same location as the second aspiration position or at two different locations. A pipetting mechanism draws at least a portion of the liquid standard sample 50 from the standard sample container 20 located at the third aspiration position and dispenses it into a first reaction container. A reagent dispensing mechanism 150 draws reagent from a reagent container and dispenses it into the first reaction container, and also draws reagent from a reagent container and dispenses it into a second reaction container. A sample determination mechanism 140 determines the first reaction solution in the first reaction container, which is at least composed of the liquid standard sample 50 dispensed into the first reaction container and reagents, and determines the second reaction solution in the second reaction container, which is at least composed of the sample to be tested dispensed into the second reaction container and reagents. The pipetting mechanism and the reagent dispensing mechanism 150 may be the same mechanism or two independent mechanisms. In this alternative implementation, the dispensing of liquid standard sample 50 may share a pipette with the dispensing of reagents, and be delivered from the reconstitution device 200 to the standard sample container 20 containing at least a portion of the liquid standard sample 50 for storage in the reagent area; or the dispensing of liquid standard sample 50 may not share a pipette with the dispensing of the sample to be tested or with the dispensing of reagents.

[0378] In one embodiment, the reconstitution device 200 is further configured to reconstitute the lyophilized reagent into a first liquid reagent; the reconstitution solution dispensing mechanism 210 is further configured to perform a reconstitution solution dispensing operation on a first reagent container containing the lyophilized reagent, so as to reconstitute the lyophilized reagent into a first liquid reagent through the reconstitution solution; the first transfer mechanism 250 is further configured to transfer the first reagent container containing at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent to a third container carrier; and the carrier scheduling mechanism 270 is further configured to move the third container carrier containing the first reagent container, and the first reagent container containing at least a portion of the first liquid reagent, from the reconstitution device 200... 00 is dispatched to the transmission device 300; the transmission device 300 is further configured to: transmit a third container carrier containing a first reagent container and the first reagent container containing at least a portion of a first liquid reagent formed by reconstitution of lyophilized reagent in the reconstitution device 200 to the sample testing device 100; the sample testing device 100 measures the sample to be tested to obtain sample test data, including: the sample testing device 100 measures a test liquid made of at least the sample to be tested and the first liquid reagent to obtain sample test data; wherein, the third container carrier and the first container carrier 30 are two independent carriers or the same carrier.

[0379] In one embodiment, the sample testing device 100 includes a reagent storage mechanism 160, a reagent dispensing mechanism 150, a sample dispensing mechanism 130, a second transfer mechanism, and a sample testing mechanism 140. The second transfer mechanism is used to transfer a first reagent container containing at least a portion of a first liquid reagent formed by reconstitution of lyophilized reagent from a third container carrier to the reagent storage mechanism 160. The sample dispensing mechanism 130 is used to draw the sample to be tested from the sample container and dispense it into the reaction container. The reagent dispensing mechanism 150 is used to draw at least a portion of the first liquid reagent from the first reagent container in the reagent storage mechanism 160 and dispense the drawn first liquid reagent into the reaction container. The sample testing mechanism 140 is used to measure the test solution in the reaction container, which is at least composed of the sample to be tested and the first liquid reagent, to obtain sample test data.

[0380] In one implementation, the sample dispensing mechanism 130 includes a first sample needle, a first suction / dispensing driving component, and a first motion driving component. The first sample needle is used to aspirate and dispense liquid standard sample 50. The first suction / dispensing driving component provides driving force for the first sample needle to aspirate and dispense the sample. The first motion driving component drives the first sample needle to move in two-dimensional or three-dimensional space, so that the first sample needle moves to different positions, such as a standby position, aspiration position, sample dispensing position, and cleaning position.

[0381] In one implementation, the first suction / discharge driving component is a syringe. Of course, in specific applications, the arrangement of the first suction / discharge driving component is not limited to this; for example, it could also be a pump or a positive / negative pressure driving structure.

[0382] In one embodiment, the standard sample container 20 has a stopper 2201 and / or a cap 2202, and the first sample needle has a puncture function, i.e., the first sample needle is a puncture needle. The first sample needle is used to puncture at least the stopper 2201 and / or cap 2202 of the standard sample container 20 to at least partially penetrate into the standard sample container 20 and aspirate the liquid standard sample 50. The first sample needle can directly puncture the sealing member 22 at the mouth of the standard sample container 20 for sample aspiration, eliminating the need for a stopper removal mechanism 190 and a cap removal mechanism 101, which simplifies the structure of the sample analysis device 10, and improves the measurement efficiency by saving the time spent on stopper removal and / or cap removal. In this embodiment, the reconstituted liquid standard sample 50 can be directly measured without secondary dispensing to other containers, and without removing the stopper 2201 and / or cap 2202 of the container holding the standard sample. This makes the measurement of the standard sample more convenient and helps reduce the contact between the liquid standard sample 50 and air, making the performance of the liquid standard sample 50 more stable. The principle of the pipette of the above-mentioned reconstituted solution dispensing mechanism 210 can be referred to the first sample needle, and will not be described in detail here.

[0383] As one implementation method, the first sample needle adopts a one-absorption-one-measurement scheme, that is, the first sample needle aspirates the corresponding amount of standard sample or test sample for each item. Of course, in specific applications, as an alternative implementation method, the first sample needle can also adopt a one-absorption-multiple-measurement scheme, that is, if it is a single-item standard sample or a single-item test sample, the corresponding amount of sample or test sample for that item is aspirated at once; if it is a multi-item composite standard sample or a multi-item test sample, the sum of the standard sample amounts corresponding to all standard sample items is aspirated at once, or the sum of the test sample amounts corresponding to all sample measurement items is aspirated at once.

[0384] In one embodiment, the sample determination mechanism 140 includes an incubation component 141 and a determination component 142. The incubation component 141 is used to incubate a first liquid containing at least the sample to be tested in a second reaction container to prepare a second liquid and to incubate a third liquid containing at least a liquid standard sample 50 in a first reaction container to prepare a fourth liquid. The determination component 142 is used to determine the second reaction liquid in the second reaction container, which is at least made of the second liquid and a reagent, and to determine the first reaction liquid in the first reaction container, which is at least made of the fourth liquid and a reagent.

[0385] In one embodiment, the measuring component 142 includes at least one illumination component and multiple light receiving components. The illumination component emits light towards a first reaction container containing a first reaction liquid and towards a second reaction container containing a second reaction liquid. The multiple first light receiving components are respectively used to receive light information generated after the light is transmitted, reflected, or scattered by the first or second reaction liquid. Specifically, the light receiving component can be a photodetector (PD), which can realize photoelectric conversion.

[0386] In one embodiment, the measuring component 142 further includes a measuring support component, which has multiple detection holes, each capable of accommodating a reaction vessel for measurement. The illumination component uses light to irradiate the reaction vessel containing the first or second reaction liquid within the detection hole, and the light is received by the light receiving component. By analyzing the received light intensity signal, the sample to be tested or the liquid standard sample 50 is analyzed. In this embodiment, the measuring support component and the incubation component 141 are independently configured; however, in specific applications, as an alternative embodiment, the measuring support component and the incubation component 141 can also be integrated into one unit.

[0387] In one embodiment, the sample determination apparatus 100 further includes a reagent storage mechanism 160 and a reagent dispensing mechanism 150. The reagent storage mechanism 160 is used to hold a reagent container, which contains reagents for performing sample determination or standard sample determination. The reagent dispensing mechanism 150 is used to draw reagents from the reagent container in the reagent storage mechanism 160 and dispense the drawn reagents into the reaction vessel.

[0388] In one implementation, the sample testing data includes coagulation test data of the sample to be tested. The sample testing device 100 is a coagulation testing device used to measure coagulation-related parameters of the sample to be tested. The sample testing device 100 employs at least one method selected from coagulation, immunoturbidimetry, and chromogenic substrate methods to measure coagulation parameters in a first reaction solution prepared from at least the sample to be tested and reagents. The main procedure for the coagulation testing includes: adding the sample to be tested and reagents (possibly one or more reagents) to a reaction vessel, mixing and incubating the mixture of the added sample and reagents to prepare a second reaction solution, then illuminating the second reaction vessel containing the second reaction solution with light emitted from an illumination component, which is received by a light receiving component (e.g., a detector PD), and analyzing the received optical signal (e.g., light intensity) to complete the analysis of the second reaction solution. Of course, in specific applications, the sample testing device 100 is not limited to a coagulation testing device; for example, it can also be a biochemical testing device, an immunoassay device, or a blood cell testing device.

[0389] In one implementation, the reagent dispensing mechanism 150 includes a mixing reagent dispensing mechanism 151 and a triggering reagent dispensing mechanism 152. The mixing reagent dispensing mechanism 151 is used to draw mixed reagents from a mixing reagent container and dispense them into the reaction vessel, while the triggering reagent dispensing mechanism 152 is used to draw triggering reagents from a triggering reagent container and dispense them into the reaction vessel. The mixing reagent dispensing mechanism 151 and the triggering reagent dispensing mechanism 152 are independently configured and can operate in parallel, allowing the mixing reagent dispensing operation of one reaction vessel to be performed simultaneously with the triggering reagent dispensing operation of another reaction vessel. Of course, in specific applications, as an alternative implementation, the mixing reagent dispensing operation and the triggering reagent dispensing operation can also be performed by the same reagent dispensing mechanism.

[0390] In one embodiment, the mixing reagent dispensing mechanism 151 includes a mixing reagent needle, a second suction / dispensing driving component for driving the mixing reagent needle to aspirate and dispense the mixed reagent, and a second motion driving component for driving the mixing reagent needle to perform spatial movement. The triggering reagent dispensing mechanism 152 includes a triggering reagent needle, a third suction / dispensing driving component for driving the triggering reagent needle to aspirate and dispense the triggering reagent, and a third motion driving component for driving the triggering reagent needle to perform spatial movement.

[0391] In one implementation, each coagulation assay includes at least a sample addition period, an incubation period, a trigger reagent period, and a assay period, performed sequentially. During the sample addition period, the control device 400 controls the sample addition operation. During the incubation period, the control device 400 controls the incubation operation. During the trigger reagent period, the control device 400 controls the addition of the trigger reagent. During the assay period, the control device 400 controls the assay operation.

[0392] In one implementation, each coagulation test includes a cup-discarding period after the testing period. That is, each coagulation test includes a sample addition period, an incubation period, a trigger reagent period, a testing period, and a cup-discarding period, performed sequentially. During the cup-discarding period, the control device 400 controls the discarding of the reaction container after the test is completed.

[0393] In one implementation, the coagulation assays that the sample testing device 100 can perform include, but are not limited to: prothrombin (PT), activated partial thromboplastin (APTT), fibrinogen (FIB), thrombin (TT), and antithrombin III (ATIII). The activated partial thromboplastin (APTT) assay is a multi-reagent assay, requiring the addition of mixed reagents during incubation to prepare the reaction solution.

[0394] In one implementation, the sample analysis device 10 includes a single sample measuring device 100, i.e., the sample analysis device 10 is a standalone sample analyzer. Of course, in specific applications, as an alternative implementation, the sample analysis device 10 may also include two or more sample measuring devices 100, i.e., the sample analysis device 10 may also be a sample analysis pipeline or a sample cascade system.

[0395] In one implementation, the control device 400 is equipped with a first standard sample measurement working mode and a second standard sample measurement working mode. Based on feedback information from the first information acquisition component 201, the control device 400 performs measurement on the fed standard sample using one of the first and second standard sample measurement working modes.

[0396] The first standard sample determination working mode includes the following steps: the freeze-dried standard sample 40 is reconstituted into a liquid standard sample 50 by adding a reconstituted solution, mixing, and standing, and is stored in the refrigeration mechanism (i.e., storage mechanism 230) of the reconstitution device 200. When the preset standard sample determination rules (such as the first preset condition mentioned above) are met for the first time, the control device 400 sends a command to the reconstitution device 200 to retrieve the liquid standard sample 50. The liquid standard sample 50 is output from the reconstitution device 200 to the transfer track 310, and transported by the transfer track 310 to the loading area 111 of the sample determination device 100. After the sample determination device 100 completes the sampling and analysis, the sample determination device 100 outputs the sample to the transfer track 310, and then the transfer track 310 returns it to the reconstitution device 200 and stores it in the refrigeration mechanism. Once the preset standard sample determination rules are met again, the liquid standard sample 50 in the refrigeration unit is checked first. If it is within its expiration date and there is sufficient remaining quantity, the liquid standard sample 50 is retrieved directly, the above retrieval steps are repeated, and the standard sample determination is completed. If it has exceeded its expiration date or there is insufficient remaining quantity, the lyophilized standard sample 40 needs to be reconstituted and restored, and the above reconstitution and transfer steps are repeated.

[0397] In the second standard sample determination mode, the operator can directly place the testable liquid standard sample 50 into the reconstitution device 200 and transfer it to the refrigeration unit. Once the preset standard sample determination rules are met for the first time, the control device 400 sends a command to the reconstitution device 200 to retrieve the liquid standard sample 50. The liquid standard sample 50 is output from the reconstitution device 200 to the track of the transmission device 300, which then transports it to the loading area 111 of the sample determination device 100. After the sample determination device 100 completes sampling and analysis, the sample is output from the sample determination device 100 to the track of the transmission device 300, and then returned to the reconstitution device 200 and stored in the refrigeration unit. When the preset standard sample determination rules are met again, the liquid standard sample 50 in the refrigeration unit is checked first. If it is within its validity period and has sufficient quantity, the liquid standard sample 50 is retrieved directly, and the above scheduling steps are repeated to complete the standard sample determination. If the expiration date is exceeded or the remaining quantity is insufficient, use another newly loaded liquid standard sample 50 in the refrigerated unit.

[0398] The main difference between the first and second standard sample determination modes lies in the form of the standard samples placed into the reconstitution device 200 by the operator. Therefore, the reconstitution device 200 additionally needs to recognize the form of the externally input standard samples. This recognition can be automatic, such as using visual identification of differences in the outer packaging of the standard samples or using a scanner to identify differences in the identification codes of the standard samples. Alternatively, the operator can specify the form of the input standard samples; for example, when loading the standard samples, an interface can be provided for the operator to select the standard sample type.

[0399] As one implementation method, the sample analysis device 10 of this embodiment is an instrument capable of refrigerating, automatically reconstituted, and automatically transferring the freeze-dried standard sample 40 to the sample determination device 100. The reconstituted device 200 of this instrument has a built-in refrigeration chamber, a mixing mechanism 220, a rewarming mechanism 240, a carrier scheduling mechanism 270, a first transfer mechanism 250, and a reconstituted solution dispensing mechanism 210, etc. The automatic reconstituted and sample-loading functions of the freeze-dried standard sample 40 are realized through the carrier scheduling mechanism 270, the first transfer mechanism 250, and the reconstituted solution dispensing mechanism 210.

[0400] In this embodiment, the working principle of the sample analysis device 10 includes:

[0401] (1) The reconstitution device 200 and the sample determination device 100, through the cooperation of the carrier scheduling mechanism 270 and the transmission device 300, realize the function of automatic sample loading and detection of standard samples.

[0402] (2) Automatic reconstitution method: The operator puts the freeze-dried standard sample 40 into the feeding mechanism 260 in advance, and transfers it to the storage mechanism 230 for storage through the cooperation of the carrier scheduling mechanism 270 and the first transfer mechanism 250. When there is a need for standard sample testing, the first transfer mechanism 250 grabs the freeze-dried standard sample 40 from the storage mechanism 230 and transfers it to the rewarming mechanism 240. After the temperature returns to room temperature, the reconstitution solution is injected into the standard sample container 20 containing the freeze-dried standard sample 40 using a puncture needle (pipette). After standing for a period of time, the first transfer mechanism 250 transfers the standard sample container 20 to the mixing mechanism 220. The mixing mechanism 220 will perform different degrees of inversion and mixing according to the sample type. After standing to eliminate air bubbles, the operation of reconstituted freeze-dried standard sample 40 into liquid standard sample 50 is completed.

[0403] (3) Automatic sample loading method: The carrier scheduling mechanism 270 pulls the empty first container carrier 30 from the carrier buffer mechanism 280 and transfers it to the first loading position 207. The first transfer mechanism 250 places the reconstituted standard sample container 20 into the hole of the first container carrier 30 one by one. The carrier scheduling mechanism 270 transfers the first container carrier 30 with the standard sample container 20 placed in the first loading position 207 to the transfer track 310. The first container carrier 30 is then transferred by the transfer track 310 to the sample measuring device 100 for testing.

[0404] (4) The transfer function of the first transfer mechanism 250 is realized by the gripping and picking up of the robot arm, as well as the horizontal drive and lifting drive of the robot arm. Under the pulling force of the second elastic element 2514, the two gripping arms rotate and close around the same second connecting shaft 2518, pressing the bottle body of the standard sample container 20 on both sides to realize the gripping function of the standard sample container 20; the second motor 2515 drives the cam component 2501 to move, opening the two gripping arms and releasing the pressing effect on the bottle body of the standard sample container 20 to realize the picking up and putting down function of the standard sample container 20.

[0405] (5) The scheduling function of the carrier scheduling mechanism 270 is achieved by the horizontal and vertical movement of the claw in the carrier accommodating channel 2711, and at the same time, the position of the standard sample container 20 is detected by the sensor at multiple holes on the first container carrier 30.

[0406] (6) The storage mechanism 230 has a rotatable porous disc structure inside, which can store multiple standard sample containers 20. In order to ensure the refrigeration effect of the storage mechanism 230, a sliding door 232 is provided at the loading and unloading port (i.e., the opening 2311) of the standard sample container 20. When the standard sample container 20 needs to be retrieved, the robotic arm opens the door 232; when the instrument is idle, the robotic arm closes the door 232 to isolate the storage mechanism 230 from the outside air.

[0407] (7) The mixing mechanism 220 is mainly composed of two clamping seats and a first elastic element 2213. The two clamping seats press the bottle body of the standard sample container 20 under the pulling force of the first elastic element 2213. Under the drive of the first motor 2221, the mixing seat 221 rotates 360° around the first connecting shaft 2215 to mix.

[0408] The sample analysis device 10 provided in this embodiment can realize the automatic reconstitution and automatic instrument testing of lyophilized materials (including but not limited to lyophilized quality control materials, lyophilized calibrators, and lyophilized reagents). It has a high degree of automation, saves the operation of operators, avoids human error to improve the consistency of reconstitution, and saves the preparation time of the sample analysis device 10 before testing.

[0409] A second aspect of the present invention provides a sample analysis device 10, the sample analysis device 10 comprising:

[0410] Reconstitution apparatus 200 is used to reconstitute lyophilized standard sample 40 into liquid standard sample 50;

[0411] The sample measuring device 100 is used to measure the sample to be tested to obtain sample test data, and to measure the liquid standard sample 50 to obtain reference test data.

[0412] The transfer device 300 is located outside the reconstitution device 200 and is used to: transfer a first container carrier 30 containing a standard sample container 20 and the standard sample container 20 containing at least a partially liquid standard sample 50 formed by reconstitution of lyophilized standard sample 40 in the reconstitution device 200 to the sample determination device 100.

[0413] Control device 400 is used to control the operation of at least one of the reconstitution device 200, sample determination device 100, and transfer device 300.

[0414] The reconstitution device 200 includes a reconstitution solution dispensing mechanism 210 and a first transfer mechanism 250. The reconstitution solution dispensing mechanism 210 is used to perform a reconstitution solution dispensing action on the standard sample container 20 containing the lyophilized standard sample 40 to reconstitute the lyophilized standard sample 40 into a liquid standard sample 50 using the reconstitution solution. The first transfer mechanism 250 is used to transfer the standard sample container 20 containing at least a portion of the liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to a first container carrier 30 located on the transfer device 300.

[0415] In one embodiment, the reconstitution device 200 further includes a first housing 204, and the reconstitution solution dispensing mechanism 210 is located inside the first housing 204;

[0416] The transmission device 300 includes a transmission track 310, both the transmission track 310 and the sample measuring device 100 are located outside the first housing 204, and the first housing 204 has an output port that is directly opposite one end of the transmission track 310.

[0417] The first transfer mechanism 250 is used to transfer a standard sample container 20 containing at least a partially liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to a first container carrier 30 located on the transfer track 310 through an output port.

[0418] In one implementation, the control device 400 is configured as follows:

[0419] The control transfer track 310 transfers the first container carrier 30, which is output from the sample determination device 100 and loaded with the standard sample container 20, toward the reconstitution device 200.

[0420] The first transfer mechanism 250 controls the transfer of the standard sample container 20 from the first container carrier 30 located on the transfer track 310 to the reconstitution device 200 for storage or recovery.

[0421] Other parts of the sample analysis device 10 provided in the second aspect of the present invention can be referred to the description of the sample analysis device 10 in the first aspect, and will not be described in detail here.

[0422] A third aspect of the present invention provides a sample analysis device 10, the sample analysis device 10 comprising:

[0423] Reconstitution apparatus 200, used to reconstitute lyophilized reagent into a first liquid reagent;

[0424] The sample measuring device 100 is used to measure a test solution made of at least a sample to be tested and a first liquid reagent to obtain sample test data.

[0425] The transfer device 300 is used to: transfer a third container carrier containing a first reagent container, wherein the first reagent container contains at least a portion of a first liquid reagent formed by reconstitution of lyophilized reagent in the reconstitution device 200, to the sample determination device 100.

[0426] Control device 400 is used to control the operation of at least one of the reconstitution device 200, sample determination device 100, and transfer device 300.

[0427] The reconstitution device 200 includes a reconstitution solution dispensing mechanism 210, a first transfer mechanism 250, and a carrier scheduling mechanism 270. The reconstitution solution dispensing mechanism 210 is used to perform a reconstitution solution dispensing action on a first reagent container loaded with lyophilized reagent, so as to reconstitute the lyophilized reagent into a first liquid reagent through the reconstitution solution.

[0428] The first transfer mechanism 250 is used to transfer a first reagent container containing at least a portion of a first liquid reagent formed by reconstitution of a lyophilized reagent to a third container carrier;

[0429] The vehicle dispatching mechanism 270 is used to dispatch a third container vehicle, which is loaded with a first reagent container and at least part of the first liquid reagent, from the reconstitution device 200 to the transfer device 300.

[0430] In one embodiment, the sample testing device 100 includes a reagent storage mechanism 160, a reagent dispensing mechanism 150, a sample dispensing mechanism 130, a second transfer mechanism, and a sample testing mechanism 140. The second transfer mechanism is used to transfer a first reagent container containing at least a portion of a first liquid reagent formed by reconstitution of lyophilized reagent from a third container carrier to the reagent storage mechanism 160. The sample dispensing mechanism 130 is used to draw the sample to be tested from the sample container and dispense it into the reaction container. The reagent dispensing mechanism 150 is used to draw at least a portion of the first liquid reagent from the first reagent container in the reagent storage mechanism 160 and dispense the drawn first liquid reagent into the reaction container. The sample testing mechanism 140 is used to measure the test solution in the reaction container, which is at least composed of the sample to be tested and the first liquid reagent, to obtain sample test data.

[0431] Other parts of the sample analysis device 10 provided in the third aspect of the present invention can be referred to the description of the sample analysis device 10 in the first aspect, and will not be described in detail here.

[0432] A fourth aspect of the present invention provides a sample analysis device 10, the sample analysis device 10 comprising:

[0433] Reconstitution apparatus 200, used to reconstitute lyophilized reagent into a first liquid reagent;

[0434] The sample measuring device 100 is used to measure a test solution made of at least a sample to be tested and a first liquid reagent to obtain sample test data.

[0435] The transfer device 300 is located outside the reconstitution device 200 and is used to: transfer a third container carrier containing a first reagent container and the first reagent container containing at least a portion of a first liquid reagent formed by reconstitution of lyophilized reagent in the reconstitution device 200 to the sample determination device 100.

[0436] Control device 400 is used to control the operation of at least one of the reconstitution device 200, sample determination device 100, and transfer device 300.

[0437] The reconstitution device 200 includes a reconstitution solution dispensing mechanism 210 and a first transfer mechanism 250. The reconstitution solution dispensing mechanism 210 is used to perform a reconstitution solution dispensing action on a first reagent container loaded with lyophilized reagent to reconstitute the lyophilized reagent into a first liquid reagent through the reconstitution solution. The first transfer mechanism 250 is used to transfer the first reagent container loaded with at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent to a third container carrier located on the transfer device 300.

[0438] The reconstitution, transfer, and transport processes of the lyophilized reagents can be referred to lyophilized standard sample 40, and will not be described in detail here.

[0439] Other parts of the sample analysis device 10 provided in the fourth aspect of the present invention can be referred to the description of the sample analysis device 10 in the first aspect, and will not be described in detail here.

[0440] A fifth aspect of the present invention provides a resolution apparatus 200, the resolution apparatus 200 comprising:

[0441] The first housing 204 has an output port;

[0442] The reconstitution solution dispensing mechanism 210 is located inside the first outer shell 204 and is used to perform a reconstitution solution dispensing action on the standard sample container 20 containing the lyophilized standard sample 40, so as to reconstitute the lyophilized standard sample 40 into a liquid standard sample 50 through the reconstitution solution.

[0443] The first transfer mechanism 250 is located inside the first housing 204 and is used to transfer the standard sample container 20 containing at least a partially liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to the first container carrier 30.

[0444] The carrier scheduling mechanism 270 is located inside the first housing 204 and is used to output the first container carrier 30, which is loaded with standard sample container 20 and at least part of liquid standard sample 50, from the output port to the outside of the first housing 204.

[0445] In one embodiment, the reconstitution device 200 further includes a storage mechanism 230, a reheating mechanism 240, a reconstitution solution buffer mechanism 290, and a carrier buffer mechanism 280, all of which are located within the first housing 204.

[0446] Storage mechanism 230 is used to store standard sample container 20 containing freeze-dried standard sample 40;

[0447] The rewarming mechanism 240 is used to perform rewarming treatment on the standard sample container 20, which is from the storage mechanism 230 and contains the freeze-dried standard sample 40.

[0448] The vehicle buffer mechanism 280 is used to buffer at least the first container vehicle 30 when it is in an empty state;

[0449] The reconstitution buffer mechanism 290 is used to store a second container carrier 60 containing a reconstitution container 70 and the reconstitution container 70 containing a reconstitution solution;

[0450] The remelting apparatus 200 also has a first loading position 207 and a first unloading position 208, which are located at the same position.

[0451] The vehicle scheduling mechanism 270, the rehydration solution buffer mechanism 290, the first loading position 207, the reheating mechanism 240, and the storage mechanism 230 are arranged sequentially along the first horizontal direction X3;

[0452] In the second horizontal direction X4, the vehicle scheduling mechanism 270, the rehydration solution buffer mechanism 290, the first loading position 207, and the reheating mechanism 240 are all located on the same side of the vehicle scheduling mechanism 270;

[0453] Among them, the first horizontal direction X3 and the second horizontal direction X4 are perpendicular to each other.

[0454] In one embodiment, the remelting apparatus 200 also includes a feeding mechanism 260;

[0455] The feeding mechanism 260 is used to place a first container carrier 30 containing a standard sample container 20 and a freeze-dried standard sample 40 to feed the freeze-dried standard sample 40; or the feeding mechanism 260 is used to place a standard sample container 20 containing a freeze-dried standard sample 40 on the first container carrier 30 located in the feeding mechanism 260 to feed the freeze-dried standard sample 40; and the feeding mechanism 260 is also used to place a second container carrier 60 containing a reconstituted solution container 70 and a reconstituted solution to feed the reconstituted solution; or the reconstituted solution container 70 containing the reconstituted solution is placed on the second container carrier 60 located in the feeding mechanism 260 to feed the reconstituted solution.

[0456] The reconstitution device 200 has a first layer of space and a second layer of space. The second layer of space is located above the first layer of space. The storage mechanism 230, the reheating mechanism 240, the reconstitution buffer mechanism 290 and the carrier buffer mechanism 280 are distributed in the first layer of space, and the feeding mechanism 260 is distributed in the second layer of space.

[0457] In one embodiment, the reconstitution device 200 also includes a first display screen 203 located outside the first housing 204. The first display screen 203 is used to display management information of the standard sample container 20 and / or management information of the reconstitution container 70.

[0458] Other parts of the resolution apparatus 200 provided in the fifth aspect of the present invention can be referred to the description in the first aspect, and will not be described in detail here.

[0459] A sixth aspect of the present invention provides a control method for a sample analysis device 10, the control method comprising the following steps:

[0460] The control reconstitution dispensing mechanism 210 performs a reconstitution dispensing action on the standard sample container 20 containing the lyophilized standard sample 40, so as to reconstitute the lyophilized standard sample 40 into a liquid standard sample 50 through the reconstitution solution.

[0461] The first transfer mechanism 250 is controlled to transfer the standard sample container 20, which contains at least a partially liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40, to the first container carrier 30.

[0462] The control vehicle scheduling mechanism 270 schedules a first container carrier 30, which is loaded with a standard sample container 20 and the standard sample container 20 is loaded with at least a partially liquid standard sample 50 formed by reconstitution of lyophilized standard sample 40, from the reconstitution device 200 to the transfer device 300.

[0463] The control transmission device 300 transmits the first container carrier 30, which is scheduled to be on the transmission device 300 by the carrier scheduling mechanism 270, to the sample measuring device 100;

[0464] The control sample measuring device 100 draws at least a portion of the liquid standard sample 50 contained in the standard sample container 20 and dispenses it into the first reaction container. The control sample measuring device 100 measures the first reaction solution in the first reaction container, which is at least made from the liquid standard sample 50 dispensed into the first reaction container, to obtain reference test data.

[0465] As one implementation, before the reconstitution dispensing mechanism 210 performs the reconstitution dispensing action on the standard sample container 20 containing the lyophilized standard sample 40, the control method further includes the following steps: when the first preset condition is met, the first transfer mechanism 250 is controlled to transfer the standard sample container 20 containing the lyophilized standard sample 40 from the storage mechanism 230 to the receiving position 241 of the rewarming mechanism 240 for rewarming treatment; the first transfer mechanism 250 is controlled to transfer the standard sample container 20 after the rewarming treatment from the receiving position 241 to the reconstitution dispensing position 242.

[0466] In one implementation, after the reconstitution dispensing mechanism 210 performs a reconstitution dispensing operation on the standard sample container 20 containing the lyophilized standard sample 40, and before the first transfer mechanism 250 transfers the standard sample container 20 containing at least a portion of the liquid standard sample 50 formed by reconstitution of the lyophilized standard sample 40 to the first container carrier 30, the control method further includes the following steps: controlling the first transfer mechanism 250 to transfer the standard sample container 20 after the reconstitution dispensing operation from the reconstitution dispensing position 242 to the receiving position 241 to perform a first settling treatment; controlling the first transfer mechanism 250 to transfer the standard sample container 20 after the first settling treatment from the receiving position 241 to the mixing mechanism 220; controlling the mixing mechanism 220 to perform a mixing operation on the standard sample container 20 after the first settling treatment; and controlling the first transfer mechanism 250 to transfer the standard sample container 20 after the mixing operation from the mixing mechanism 220 to the receiving position 241 to perform a second settling treatment.

[0467] In one embodiment, after the control sample determination device 100 draws at least a portion of the liquid standard sample 50 contained in the standard sample container 20 and dispenses it into the first reaction container, the control method further includes the following steps:

[0468] The control transmission device 300 transmits the first container carrier 30, which is output from the sample determination device 100 and loaded with the standard sample container 20, toward the reconstitution device 200.

[0469] The control vehicle scheduling mechanism 270 schedules the first container vehicle 30, which comes from the transmission device 300 and is loaded with the standard sample container 20, to the first unloading position 208.

[0470] The first transfer mechanism 250 controls the standard sample container 20 to be transferred from the first container carrier 30, which is dispatched to the first unloading position 208 by the carrier dispatching mechanism 270, to the storage mechanism 230 for storage or to the recycling port 206 for disposal.

[0471] Other parts of the control method for the sample analysis device 10 provided in the sixth aspect of the present invention can be referred to the description in the first aspect, and will not be described in detail here.

[0472] A seventh aspect of the present invention provides a sample analysis device 10. The main difference between this sample analysis device 10 and the first embodiment lies in the different configuration of the pipette used for dispensing the liquid standard sample 50 and the different sampling method of the liquid standard sample 50. Specifically, in the first aspect, the pipette used for dispensing the liquid standard sample 50 is a puncture needle, and no capping or plugging operation is required when sampling the liquid standard sample 50; while in the seventh aspect, the pipette used for dispensing the liquid standard sample 50 is a non-puncture needle, and the capping and plugging operation is required before sampling the liquid standard sample 50.

[0473] Specifically, in this embodiment, the standard sample container 20 has a stopper 2201 and a cap 2202. The sample determination device 100 also includes a pipetting mechanism (e.g., a sample dispensing mechanism 130), a stopper removal mechanism 190, and a cap removal mechanism 101. The cap removal mechanism 101 is used to remove the cap 2202 of the standard sample container 20, and the stopper removal mechanism 190 is used to remove the stopper 2201 of the standard sample container 20. The pipetting mechanism includes a second pipette, which does not have a puncture function, i.e., the second pipette is a non-puncture needle. The second pipette is used to at least partially extend into the container after the cap 2202 has been removed by the cap removal mechanism 101 and the stopper 2202 has been removed by the stopper removal mechanism 190. In the standard sample container 20 after step 201, at least a portion of the liquid standard sample 50 contained therein is dispensed into the first reaction container. In this embodiment, the liquid standard sample 50 is transported to the aspiration position using the standard sample container 20 with a stopper 2201 and a cap 2202 as a carrier. The pipetting mechanism uses a second pipette without puncture function to aspirate and dispense the liquid standard sample 50. The cap removal mechanism 101 removes the cap 2202 of the standard sample container 20, and the stopper removal mechanism 190 removes the stopper 2201 of the standard sample container 20, thereby enabling the second pipette to aspirate the liquid standard sample 50 from the standard sample container 20.

[0474] In one implementation, the bottle cap 2202 is connected to the glass bottle body 21 via a threaded connection. The cap removal mechanism 101 removes the bottle cap 2202 from the glass bottle body 21 by clamping and rotating it. Specifically, the cap removal mechanism 101 can be used to clamp the glass bottle body 21 using the first clamping mechanism 102, and then rotate the cap 2202 to detach it from the glass bottle body 21. However, in specific applications, the configuration of the cap removal mechanism 101 is not limited to this.

[0475] In one embodiment, the bottle stopper 2201 is inserted into the mouth of the glass bottle body 21 using an interference fit. The de-cork mechanism 190 includes a hollow de-cork needle 191, a lifting mechanism for driving the de-cork needle 191 to move up and down, and a horizontal moving mechanism for driving the de-cork needle 191 to move horizontally. The de-cork needle 191 has a hollow inner hole 1911, and the de-cork needle 191 can penetrate the bottle stopper 2201 to allow the interior of the first container to be connected to the external atmosphere in order to balance the air pressure. The decapsulation operation is as follows: the glass bottle body 21 is clamped and fixed by the second clamping mechanism 103. The lifting mechanism drives the decapsulation needle 191 to penetrate the bottle stopper 2201. The lifting mechanism also drives the decapsulation needle 191 to move upward. When the static friction force f1 between the decapsulation needle 191 and the bottle stopper 2201 is greater than the static friction force f2 between the bottle stopper 2201 and the glass bottle body 21, the bottle stopper 2201 is lifted and detached from the glass bottle body 21 by the decapsulation needle 191. The horizontal moving mechanism drives the decapsulation needle 191 with the bottle stopper 2201 to move to the preset decapsulation position. The lifting mechanism then drives the decapsulation needle 191 to move upward, causing the decapsulation needle 191 and the bottle stopper 2201 to detach, and the bottle stopper 2201 is discarded. After the bottle stopper 2201 of the standard sample container 20 is removed, the second pipette can normally be inserted into the standard sample container 20 to draw liquid standard sample 50. Of course, in specific applications, the setting of the decapsulation mechanism 190 and the decapsulation method are not limited to this.

[0476] In addition to the above, other parts of the sample analysis device 10 provided in the seventh aspect of the present invention can be referred to the first to sixth aspects, and will not be described in detail here.

[0477] The eighth aspect of this invention provides a sample analysis device 10. The main difference between this sample analysis device 10 and the second aspect lies in the different sealing components 22 of the standard sample container 20 and the different sampling methods for the liquid standard sample 50. Specifically, in the second aspect, the sealing component 22 of the standard sample container 20 includes a stopper 2201 and a cap 2202, and the sample needle used to dispense the liquid standard sample 50 is a non-puncture needle. Before sampling the liquid standard sample 50, the cap and stopper need to be removed. In the eighth aspect, the sealing component 22 of the standard sample container 20 includes a stopper 2201 but does not include a cap 2202, and the pipette used to dispense the liquid standard sample 50 is a non-puncture needle. Before sampling the liquid standard sample 50, the stopper needs to be removed.

[0478] Specifically, in this embodiment, the standard sample container 20 (e.g., the first container) has a stopper 2201. The sample determination device 100 also includes a stopper removal mechanism 190, which is used to remove the stopper 2201 from the standard sample container 20. The pipetting mechanism includes a second pipette, which does not have a puncture function. The second pipette is used to at least partially extend into the standard sample container 20 after the stopper 2201 has been removed by the stopper removal mechanism 190, and to aspirate at least a portion of the liquid standard sample 50 contained therein and dispense it into the first reaction container. The arrangement and method of the stopper removal mechanism 190 in this embodiment can be referred to in Embodiment 3, and will not be described in detail here.

[0479] In addition to the above, other parts of the sample analysis device 10 provided in the first aspect of the present invention can be referred to the first to seventh aspects, and will not be described in detail here.

[0480] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A sample analysis device, characterized in that: include: A reconstitution device, wherein the reconstitution device is used to reconstitute lyophilized standard samples into liquid standard samples; A sample measuring device is used to measure the sample to be tested to obtain sample detection data, and to measure the liquid standard sample to obtain reference detection data. A transmission device, the transmission device being used to: transmit a first container carrier containing a standard sample container, wherein the standard sample container contains at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample in the reconstitution device, to the sample determination device; A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device; The reconstitution device includes a reconstitution solution dispensing mechanism, a first transfer mechanism, and a carrier scheduling mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on the standard sample container loaded with the lyophilized standard sample, so as to reconstitute the lyophilized standard sample with the reconstitution solution to form the liquid standard sample. The first transfer mechanism is used to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier; The carrier scheduling mechanism is used to schedule the first container carrier, which is loaded with the standard sample container and the standard sample container is loaded with at least part of the liquid standard sample, from the reconstitution device to the transmission device.

2. The sample analysis device as described in claim 1, characterized in that: The remelting apparatus further includes a carrier buffer mechanism, which is at least used to buffer the first container carrier when it is in an unloaded state; The first transfer mechanism transfers the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier, including: the first transfer mechanism transferring the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier from the carrier buffer mechanism.

3. The sample analysis device as described in claim 2, characterized in that: The reconstitution apparatus further includes a storage mechanism, which is at least used to store the standard sample container containing the lyophilized standard sample; The reconstitution dispensing mechanism performs a reconstitution dispensing action on the standard sample container containing the lyophilized standard sample, including: the reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container from the storage mechanism that contains the lyophilized standard sample.

4. The sample analysis device as described in claim 3, characterized in that: The carrier buffer mechanism is also used to buffer the first container carrier that contains the standard sample container and the standard sample container contains the freeze-dried standard sample; The first transfer mechanism is also used to transfer the standard sample container containing the freeze-dried standard sample from the first container carrier from the carrier buffer mechanism to the storage mechanism.

5. The sample analysis device as described in claim 4, characterized in that: The reconstitution apparatus further includes a rewarming mechanism, which is at least used to perform a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample. The reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that comes from the storage unit and contains the lyophilized standard sample, including: the reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that comes from the storage unit and has completed the rewarming treatment; Preferably, in the first horizontal direction, the rewarming mechanism is located between the storage mechanism and the carrier buffer mechanism; in the second horizontal direction, the rewarming mechanism and the carrier buffer mechanism are located on the side of the carrier scheduling mechanism away from the sample measuring device, and the first horizontal direction and the second horizontal direction are perpendicular to each other; Preferably, the reconstitution device further includes a cleaning mechanism for performing a cleaning action on the reconstitution dispensing mechanism after the reconstitution dispensing action is completed; more preferably, in the first horizontal direction, the cleaning mechanism is located between the storage mechanism and the reheating mechanism.

6. The sample analysis device as described in claim 5, characterized in that: The reconstitution device further includes a mixing mechanism, which is used to perform a mixing action on the standard sample container after the reconstitution dispensing action is completed, so as to mix the liquid standard sample formed by the reconstitution of the lyophilized standard sample in the standard sample container. The first transfer mechanism transfers the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier from the carrier buffer mechanism, including: the first transfer mechanism transferring the standard sample container after the mixing action is completed to the first container carrier from the carrier buffer mechanism; Preferably, in the first horizontal direction, the mixing mechanism is located between the reheating mechanism and the storage mechanism.

7. The sample analysis device as described in claim 6, characterized in that: The mixing mechanism includes a mixing seat and a mixing power assembly. The first transfer mechanism is also used to transfer the standard sample container, which has completed the reconstitution dispensing action and is loaded with at least a portion of the liquid standard sample formed by the reconstitution of the lyophilized standard sample, to the mixing seat. The mixing power assembly performs the mixing action on the standard sample container placed in the mixing seat by at least one of the following methods: driving the mixing seat to rotate, driving the mixing seat to vibrate, performing suction and discharge actions on the liquid standard sample in the standard sample container placed in the mixing seat, blowing air into the liquid standard sample in the standard sample container placed in the mixing seat, performing stirring actions on the liquid standard sample in the standard sample container placed in the mixing seat, and performing ultrasonic mixing actions on the liquid standard sample in the standard sample container placed in the mixing seat. Preferably, the mixing seat includes a first clamping seat, a second clamping seat, and a first elastic member. The first clamping seat has a first groove, and the second clamping seat has a second groove. The first clamping seat and the second clamping seat are spliced ​​together and rotatably connected in such a way that the first groove and the second groove are directly opposite each other, so that the first groove and the second groove enclose a receiving cavity. The receiving cavity is used for at least partial insertion and positioning of the standard sample container. The two ends of the first elastic member are respectively connected to the first clamping seat and the second clamping seat so that the first groove and the second groove tend to move closer to each other. And / or, preferably, the mixing power assembly includes a first motor and a first transmission component, wherein the first transmission component is tractively connected between the first motor and the mixing seat to drive the mixing seat to rotate under the drive of the first motor.

8. The sample analysis device as described in claim 6, characterized in that: The reheating mechanism has a reheat solution dispensing position and multiple receiving positions; The first transfer mechanism is also used to transfer the standard sample container containing the lyophilized standard sample from the storage mechanism to the receiving position; The rewarming mechanism performs a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample, including: the rewarming mechanism performs a rewarming process on the standard sample container that has been transferred from the storage mechanism to the receiving position by the first transfer mechanism. The first transfer mechanism is also used to transfer the standard sample container after the rewarming treatment from the holding position to the reconstitution solution dispensing position; The reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that has come from the storage mechanism and completed the rewarming treatment, including: the reconstitution dispensing mechanism performs the reconstitution dispensing action on the standard sample container that has been transferred from the receiving position to the reconstitution dispensing position by the first transfer mechanism; Preferably, the first transfer mechanism is further configured to transfer the standard sample container after the reconstitution solution dispensing action is completed from the reconstitution solution dispensing position to the receiving position, so that the standard sample container can undergo a first settling treatment at the receiving position; the first transfer mechanism is further configured to transfer the standard sample container after the first settling treatment is completed from the receiving position to the mixing mechanism; And / or, preferably, the first transfer mechanism is further configured to transfer the standard sample container after the mixing action is completed from the mixing mechanism to the receiving position, so that the standard sample container can undergo a second settling treatment at the receiving position; the first transfer mechanism transferring the standard sample container after the mixing action is completed to the first container carrier from the carrier buffer mechanism includes: the first transfer mechanism transferring the standard sample container after the second settling treatment from the receiving position to the first container carrier from the carrier buffer mechanism.

9. The sample analysis device as described in claim 6, characterized in that: A first unloading position is formed inside the reconstitution device; The vehicle scheduling mechanism is also used to schedule the standard sample container, which is loaded with the standard sample container and the standard sample container is loaded with the freeze-dried standard sample, from the vehicle buffer mechanism to the first unloading position; The first transfer mechanism transfers the standard sample container loaded with freeze-dried standard samples from the first container carrier from the carrier buffer mechanism to the storage mechanism, including: the first transfer mechanism transfers the standard sample container loaded with freeze-dried standard samples from the first container carrier scheduled to the first unloading position by the carrier scheduling mechanism to the storage mechanism. The vehicle scheduling mechanism is also used to schedule the first container vehicle, which has been transferred to the standard sample container by the first transfer mechanism and is in an empty state, from the first unloading position to the vehicle buffer mechanism. Preferably, in the first horizontal direction, the first unloading position is located between the rewarming mechanism and the vehicle buffer mechanism.

10. The sample analysis device as described in claim 9, characterized in that: The resolution device also has a first loading position; The vehicle scheduling mechanism is also used to schedule the first container vehicle, which is in an empty state, from the vehicle buffer mechanism to the first loading position; The first transfer mechanism transfers the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier from the carrier buffer mechanism, including: transferring the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier scheduled to the first loading position by the carrier scheduling mechanism; The carrier scheduling mechanism schedules the first container carrier, which is loaded with the standard sample container and at least part of the liquid standard sample, from the reconstitution device to the transmission device, including: the carrier scheduling mechanism schedules the first container carrier, which is loaded with the standard sample container and at least part of the liquid standard sample, from the first loading position to the transmission device. The first loading position and the first unloading position may be located at the same position or at different positions; Preferably, in the first horizontal direction, the first loading position is located between the rewarming mechanism and the vehicle buffer mechanism.

11. The sample analysis device as described in claim 10, characterized in that: The reconstitution device further includes a feeding mechanism, which is used to place the first container carrier containing the standard sample container and the standard sample container containing the freeze-dried standard sample to realize the feeding of the freeze-dried standard sample, or the feeding mechanism is used to place the standard sample container containing the freeze-dried standard sample on the first container carrier located in the feeding mechanism to realize the feeding of the freeze-dried standard sample. The carrier scheduling mechanism is also used to schedule the first container carrier, which is loaded with the standard sample container and the standard sample container is loaded with the freeze-dried standard sample, from the loading mechanism to the carrier buffer mechanism or the first unloading position. Preferably, the feeding mechanism is located above the vehicle buffer mechanism; Preferably, the feeding mechanism is further configured to place the first container carrier containing the standard sample container and the standard sample container containing the liquid standard sample to realize the feeding of the liquid standard sample, or the feeding mechanism is further configured to place the standard sample container containing the liquid standard sample on the first container carrier located in the feeding mechanism to realize the feeding of the liquid standard sample. Alternatively, the transmission device is further configured to transmit the first container carrier, which contains the standard sample container and the standard sample container contains the lyophilized standard sample, to the reconstitution device; The carrier scheduling mechanism is also used to schedule the first container carrier, which comes from the transmission device and is loaded with the standard sample container and the standard sample container is loaded with the freeze-dried standard sample, to the carrier buffer mechanism or the first unloading position.

12. The sample analysis device as described in claim 11, characterized in that: The reconstitution device further includes a first information acquisition component, which is used to acquire information of a first identification code on the standard sample container before the standard sample container is transferred to the storage mechanism by the first transfer mechanism; preferably, in the first horizontal direction, the first information acquisition component is located between the storage mechanism and the rewarming mechanism; preferably, in the second horizontal direction, the first information acquisition component is arranged side by side with the mixing mechanism. And / or, the reconstitution apparatus further includes a second information acquisition component, which is used to acquire information about a second identification code on the first container carrier at at least the following times: before the first transfer mechanism transfers the standard sample container loaded with the lyophilized standard sample from the first container carrier located at the first unloading position; before the first transfer mechanism transfers the standard sample container from the storage mechanism and loaded with the liquid standard sample to the first container carrier located at the first loading position; and before the first transfer mechanism transfers the standard sample container loaded with the liquid standard sample from the first container carrier located at the first unloading position. Preferably, the second information acquisition component is used to acquire information about the second identification code on the first container carrier located at the first unloading position or at the first loading position.

13. The sample analysis device as described in claim 11, characterized in that: The reconstitution device further includes a reconstitution solution buffer mechanism, which is used to store a second container carrier containing a reconstitution solution container and the reconstitution solution container containing a reconstitution solution. The reconstitution dispensing mechanism performs a reconstitution dispensing action on the standard sample container containing the lyophilized standard sample, including: the reconstitution dispensing mechanism draws at least a portion of the reconstitution solution from the reconstitution container loaded on the second container carrier from the reconstitution buffer mechanism, and dispenses the drawn at least a portion of the reconstitution solution into the standard sample container containing the lyophilized standard sample; Preferably, in the first horizontal direction, the reconstitution buffer mechanism is located between the first unloading position and the vehicle buffer mechanism.

14. The sample analysis device as described in claim 13, characterized in that: The feeding mechanism is further configured to place the second container carrier containing the reconstituted solution container and the reconstituted solution container being filled with the reconstituted solution to realize the feeding of the reconstituted solution, or to place the reconstituted solution container containing the reconstituted solution on the second container carrier located at the feeding mechanism to realize the feeding of the reconstituted solution; the carrier scheduling mechanism is further configured to: schedule the second container carrier containing the reconstituted solution container and the reconstituted solution container being filled with the reconstituted solution from the feeding mechanism to the reconstituted solution buffer mechanism; Alternatively, the transmission device is further configured to transmit the second container carrier, which is loaded with the reconstituted solution container and the reconstituted solution container is loaded with the reconstituted solution, to the reconstituted device; the carrier scheduling mechanism is further configured to schedule the second container carrier, which is loaded with the reconstituted solution container and the reconstituted solution container, from the transmission device to the reconstituted solution buffer mechanism.

15. The sample analysis device as described in claim 14, characterized in that: The vehicle scheduling mechanism includes a base, an entry / exit drive assembly, and a spatial motion assembly. The base forms a vehicle accommodating channel. The first container vehicle has a first base whose width is adapted to the width of the vehicle accommodating channel. The second container vehicle has a second base whose width is adapted to the width of the vehicle accommodating channel. The entry / exit drive assembly is used to drive the first base to move into and out of the vehicle accommodating channel and to drive the second base to move into and out of the vehicle accommodating channel. The spatial motion component is used to drive the carrier and the entry / exit drive component to perform spatial motion, so as to move the carrier accommodating channel to at least the position docked with the loading mechanism, the position docked with the carrier buffer mechanism, the position docked with the first unloading position, the position docked with the first loading position, and the position docked with the transmission device.

16. The sample analysis device as described in claim 15, characterized in that: The first substrate is a first container rack, which has at least two first placement positions, each of which is used to place a single standard sample container; preferably, the width of the second substrate is the same as the width of the first container rack, and the second container carrier further includes a receiving seat, which is disposed on the top of the second substrate, and the top of the receiving seat has a cavity for at least part of the reconstituted solution container to be placed and positioned. Alternatively, the first substrate may be a first container holder, the first container holder having a single second placement position for placing a single standard sample container; 17. The sample analysis apparatus according to any one of claims 1 to 16, characterized in that: The reconstitution device further includes a storage mechanism and a door drive mechanism. The storage mechanism is used to store the standard sample container containing the freeze-dried standard sample. The storage mechanism includes a storage compartment and a compartment door. The storage compartment is a refrigerated compartment or a frozen compartment. The storage compartment is provided with a compartment opening for the first transfer mechanism to take out and put in the standard sample container. The compartment door is provided at the compartment opening for opening or closing the compartment opening. The door drive mechanism is used to drive the door to move, so that the door opens or closes the opening. Wherein, the door drive mechanism and the first transfer mechanism are either the same mechanism or two different mechanisms; Preferably, the door is formed at the top of the storage compartment; And / or, the reconstitution device further includes a first display screen, which is used to display management information of the standard sample container and / or management information of the reconstitution container.

18. The sample analysis device as described in claim 1, characterized in that: The reconstitution device also includes a storage mechanism, a reheating mechanism, a reconstitution solution buffer mechanism, and a carrier buffer mechanism; The storage mechanism is used to store the standard sample container containing the freeze-dried standard sample; The rewarming mechanism is used at least to perform a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample; The vehicle buffer mechanism is used at least to buffer the first container vehicle when it is in an empty state; The reconstituted solution buffer mechanism is used to store a second container carrier containing a reconstituted solution container and the reconstituted solution container is filled with a reconstituted solution. The resolution device also has a first loading position and a first unloading position, and the first loading position and the first unloading position are located at the same position. The vehicle scheduling mechanism, the rehydration solution buffer mechanism, the first loading position, the reheating mechanism, and the storage mechanism are arranged sequentially along the first horizontal direction; In the second horizontal direction, the vehicle scheduling mechanism, the reconstitution buffer mechanism, the first loading position, and the rewarming mechanism are all located on the side of the vehicle scheduling mechanism away from the sample measuring device; Wherein, the first horizontal direction is perpendicular to the second horizontal direction.

19. The sample analysis apparatus as described in any one of claims 1 to 16 or 18, characterized in that: The reconstitution device also includes a feeding mechanism, a storage mechanism, a reheating mechanism, a reconstitution solution buffer mechanism, and a carrier buffer mechanism; The feeding mechanism is used to place the first container carrier containing the standard sample container and the standard sample container containing the lyophilized standard sample to realize the feeding of the lyophilized standard sample, or the feeding mechanism is used to place the standard sample container containing the lyophilized standard sample on the first container carrier located in the feeding mechanism to realize the feeding of the lyophilized standard sample; and the feeding mechanism is also used to place the second container carrier containing the reconstituted solution container and the reconstituted solution container containing the reconstituted solution to realize the feeding of the reconstituted solution, or to place the reconstituted solution container containing the reconstituted solution on the second container carrier located in the feeding mechanism to realize the feeding of the reconstituted solution; The storage mechanism is at least used to store the standard sample container containing the freeze-dried standard sample; The rewarming mechanism is used at least to perform a rewarming process on the standard sample container that comes from the storage mechanism and contains the freeze-dried standard sample; The vehicle buffer mechanism is used at least to buffer the first container vehicle when it is in an empty state; The reconstituted solution buffer mechanism is used to store a second container carrier containing a reconstituted solution container and the reconstituted solution container is filled with a reconstituted solution. The reconstitution device has a first layer of space and a second layer of space. The second layer of space is located above the first layer of space and is connected to the first layer of space. The storage mechanism, the reheating mechanism, the reconstitution solution buffer mechanism and the carrier buffer mechanism are distributed in the first layer of space, and the feeding mechanism is distributed in the second layer of space. Preferably, a third space is formed within the resolution device, and the third space is located below the first space; The first layer of space is provided with a recycling port that communicates with the third layer of space. The third layer of space is used to place the recycling container, and the recycling container is used to recycle the standard sample container discarded through the recycling port. The first transfer mechanism is also used to transfer the standard sample container that meets one of the following conditions to the recycling port for disposal: the standard sample container is filled with the liquid standard sample and the remaining amount of the liquid standard sample is insufficient; the standard sample container is filled with the liquid standard sample and the shelf life of the liquid standard sample has expired; or the standard sample container is filled with the lyophilized standard sample and the shelf life of the lyophilized standard sample has expired.

20. The sample analysis apparatus as described in any one of claims 1 to 16 or 18, characterized in that: The first transfer mechanism includes a clamping assembly and a horizontal driving assembly. The clamping assembly is used to clamp or release the standard sample container, and the horizontal driving assembly is connected to the clamping assembly to drive the clamping assembly to move horizontally. The reconstitution solution dispensing mechanism includes a pipette for dispensing the reconstitution solution into the standard sample container containing the lyophilized standard sample. The horizontal drive assembly is also connected to the pipette for driving the pipette to move horizontally. And / or, the standard sample container includes a glass bottle body and a sealing member, the glass bottle body forming an inner cavity and a bottle mouth, the inner cavity being used to contain a lyophilized standard sample and to contain a liquid standard sample formed by reconstitution of the lyophilized standard sample, the bottle mouth communicating with the inner cavity to allow at least a portion of the liquid standard sample to be drawn out of the inner cavity; The sealing member is used to seal the bottle opening, and the sealing member includes a bottle stopper that is at least partially inserted into the bottle opening and / or a bottle cap that is at least partially fitted outside the bottle opening; The reconstitution dispensing mechanism includes a pipette with a puncture function. The pipette is used to puncture the stopper and / or cap of the standard sample container to at least partially penetrate the standard sample container and dispense the reconstitution solution into the standard sample container.

21. The sample analysis apparatus as described in any one of claims 1 to 16 or 18, characterized in that: The reconstitution device further includes a first housing, within which the reconstitution dispensing mechanism, the first transfer mechanism, and the carrier scheduling mechanism are all located; the transmission device includes a transmission track, outside which both the transmission track and the sample determination device are located, and the first housing has an output port directly opposite one end of the transmission track; the carrier scheduling mechanism is used to schedule the first container carrier, which contains at least a portion of the liquid standard sample, to the transmission track through the output port. And / or, the sample determination device includes a second housing, the reconstitution device and the transmission device are both located outside the second housing, and the reconstitution device and the transmission device are located on adjacent sides of the second housing.

22. The sample analysis apparatus as described in any one of claims 1 to 16 or 18, characterized in that: The reconstitution device also includes a storage mechanism, a reheating mechanism, and a mixing mechanism; The control device is configured to: When the first preset condition is met, the first transfer mechanism is controlled to transfer the standard sample container containing the freeze-dried standard sample from the storage mechanism to the receiving position of the rewarming mechanism for rewarming treatment. The first transfer mechanism is controlled to transfer the standard sample container, after the rewarming treatment, from the holding position to the reconstitution solution dispensing position; The reconstitution solution dispensing mechanism is controlled to perform a reconstitution solution dispensing action on the standard sample container located at the reconstitution solution dispensing position; The first transfer mechanism is controlled to transfer the standard sample container, after the reconstitution solution dispensing action is completed, from the reconstitution solution dispensing position to the receiving position to perform the first settling process; The first transfer mechanism is controlled to transfer the standard sample container, after the first settling treatment, from the holding position to the mixing mechanism; The mixing mechanism is controlled to perform a mixing action on the standard sample container after the first settling treatment is completed; The first transfer mechanism is controlled to transfer the standard sample container, after the mixing action is completed, from the mixing mechanism to the receiving position to perform the second settling process; The first transfer mechanism is controlled to transfer the standard sample container, after the second settling treatment, from the receiving position to the first container carrier located at the first loading position; The vehicle scheduling mechanism controls the first container vehicle, which is loaded with the standard sample container and has completed the second settling process, to be scheduled from the first loading position to the transmission device. The control system transfers the first container carrier, which is dispatched to it by the carrier scheduling mechanism and is loaded with the standard sample container, to the sample determination device. The sample measuring device is controlled to draw at least a portion of the liquid standard sample loaded in the standard sample container from the first container carrier of the transmission device and dispense it into the first reaction container. The sample measuring device is controlled to measure the first reaction liquid in the first reaction container, which is made from at least the liquid standard sample dispensed into the first reaction container, to obtain the reference detection data. Preferably, the lyophilized standard sample is a lyophilized quality control product, and the reference test data is quality control data; the sample analysis device is pre-stored with at least one of the following first preset conditions: reaching a first preset time point of a first preset cycle, the cumulative running time of the sample analysis device since the last quality control item measurement reaching a first preset time, the number of times the sample analysis device continuously measures the sample to be tested reaching a first preset number, the cumulative number of times the sample analysis device measures the sample to be tested since the last quality control item measurement reaching a second preset number, changing the reagent container to supply reagents, and obtaining information on the execution of quality control items according to the instructions input by the operator through the human-computer interaction device; Preferably, the control device is further configured to: The transmission device is controlled to transport the first container carrier, which outputs from the sample determination device and is loaded with the standard sample container, toward the reconstitution device; The vehicle scheduling mechanism is controlled to schedule the first container vehicle, which comes from the transmission device and is loaded with the standard sample container, to the first unloading position; The first transfer mechanism is controlled to transfer the standard sample container from the first container carrier, which has been dispatched to the first unloading position by the carrier scheduling mechanism, to the storage mechanism for storage or to the recycling port for disposal.

23. The sample analysis apparatus as described in any one of claims 1 to 16 or 18, characterized in that: The freeze-dried standard sample is a freeze-dried quality control sample, and the reference test data is quality control data. Alternatively, the lyophilized standard sample may be a lyophilized calibrator, and the reference test data may be calibration data.

24. The sample analysis apparatus as described in any one of claims 1 to 16 or 18, characterized in that: The reconstitution device is also used to reconstitute the lyophilized reagent into a first liquid reagent; The reconstitution solution dispensing mechanism is also used to perform a reconstitution solution dispensing action on the first reagent container containing the lyophilized reagent, so as to reconstitute the lyophilized reagent with the reconstitution solution to form the first liquid reagent; The first transfer mechanism is also used to transfer the first reagent container, which contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent, to the third container carrier; The vehicle scheduling mechanism is also used to schedule the third container vehicle, which is loaded with the first reagent container and the first reagent container is loaded with at least part of the first liquid reagent, from the reconstitution device to the transmission device; The transmission device is further configured to: transmit the third container carrier, which contains the first reagent container and the first reagent container contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent in the reconstitution device, to the sample determination device; The sample testing device measures the sample to be tested to obtain sample test data, including: the sample testing device measures a test solution made of at least the sample to be tested and the first liquid reagent to obtain the sample test data; Wherein, the third container carrier and the first container carrier are two independent carriers or are the same carrier; Preferably, the sample determination device includes a reagent storage mechanism, a reagent dispensing mechanism, a sample dispensing mechanism, a second transfer mechanism, and a sample determination mechanism. The second transfer mechanism is used to transfer the first reagent container, which contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent, from the third container carrier to the reagent storage mechanism. The sample dispensing mechanism is used to draw the sample to be tested from the sample container and dispense it into the reaction container. The reagent dispensing mechanism is used to draw at least a portion of the first liquid reagent from the first reagent container in the reagent storage mechanism and dispense the drawn first liquid reagent into the reaction container. The sample determination mechanism is used to determine the test solution in the reaction container, which is at least composed of the sample to be tested and the first liquid reagent, to obtain the sample detection data.

25. A sample analysis device, characterized in that: include: A reconstitution device, wherein the reconstitution device is used to reconstitute lyophilized standard samples into liquid standard samples; A sample measuring device is used to measure the sample to be tested to obtain sample detection data, and to measure the liquid standard sample to obtain reference detection data. A transmission device located outside the reconstitution device, and the transmission device being used to: transmit a first container carrier containing a standard sample container, wherein the standard sample container contains at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample in the reconstitution device, to the sample determination device; A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device; The reconstitution device includes a reconstitution solution dispensing mechanism and a first transfer mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on the standard sample container containing the lyophilized standard sample to reconstitute the lyophilized standard sample into the liquid standard sample using the reconstitution solution. The first transfer mechanism is used to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier located on the transfer device.

26. A sample analysis device, characterized in that: include: A reconstitution apparatus, wherein the reconstitution apparatus is used to reconstitute a lyophilized reagent into a first liquid reagent; A sample measuring device is used to measure a test solution made of at least the sample to be tested and the first liquid reagent to obtain the sample test data; A transmission device, the transmission device being used to: transmit the third container carrier, which is loaded with the first reagent container and the first reagent container is loaded with at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent in the reconstitution device, to the sample determination device; A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device; The reconstitution device includes a reconstitution solution dispensing mechanism, a first transfer mechanism, and a carrier scheduling mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on a first reagent container loaded with the lyophilized reagent, so as to reconstitute the lyophilized reagent with the reconstitution solution to form the first liquid reagent. The first transfer mechanism is used to transfer the first reagent container, which contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent, to the third container carrier; The vehicle scheduling mechanism is used to schedule the third container vehicle, which is loaded with the first reagent container and the first reagent container is loaded with at least part of the first liquid reagent, from the reconstitution device to the transmission device; 27. The sample analysis device as described in claim 26, characterized in that: The sample testing device includes a reagent storage mechanism, a reagent dispensing mechanism, a sample dispensing mechanism, a second transfer mechanism, and a sample testing mechanism. The second transfer mechanism is used to transfer the first reagent container, which contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent, from the third container carrier to the reagent storage mechanism. The sample dispensing mechanism is used to draw the sample to be tested from the sample container and dispense it into the reaction container. The reagent dispensing mechanism is used to draw at least a portion of the first liquid reagent from the first reagent container in the reagent storage mechanism and dispense the drawn first liquid reagent into the reaction container. The sample testing mechanism is used to measure the test solution in the reaction container, which is at least composed of the sample to be tested and the first liquid reagent, to obtain the sample detection data.

28. A sample analysis device, characterized in that: include: A reconstitution apparatus, wherein the reconstitution apparatus is used to reconstitute a lyophilized reagent into a first liquid reagent; A sample measuring device is used to measure a test solution made of at least the sample to be tested and the first liquid reagent to obtain the sample test data; A transfer device located outside the reconstitution device, and the transfer device being used to: transfer a third container carrier containing a first reagent container, wherein the first reagent container contains at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent in the reconstitution device, to the sample determination device; A control device, the control device being used to control the operation of at least one of the reconstitution device, the sample determination device, and the transmission device; The reconstitution device includes a reconstitution solution dispensing mechanism and a first transfer mechanism. The reconstitution solution dispensing mechanism is used to perform a reconstitution solution dispensing action on the first reagent container loaded with the lyophilized reagent to reconstitute the lyophilized reagent into the first liquid reagent through the reconstitution solution. The first transfer mechanism is used to transfer the first reagent container loaded with at least a portion of the first liquid reagent formed by reconstitution of the lyophilized reagent to the third container carrier located on the transfer device.

29. A resolution apparatus, characterized in that: include: A first housing, the first housing having an output port; A reconstitution solution dispensing mechanism is located inside the first outer shell and is used to perform a reconstitution solution dispensing action on a standard sample container containing a lyophilized standard sample, so as to reconstitute the lyophilized standard sample into a liquid standard sample through a reconstitution solution. A first transfer mechanism is located inside the first housing and is used to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to a first container carrier. A carrier scheduling mechanism is located inside the first housing and is used to output the first container carrier, which contains the standard sample container and at least part of the liquid standard sample, from the output port outside the first housing.

30. A control method for a sample analysis device, characterized in that: Includes the following steps: The control reconstitution dispensing mechanism performs a reconstitution dispensing action on the standard sample container containing the lyophilized standard sample, so as to reconstitute the lyophilized standard sample to form a liquid standard sample through the reconstitution solution; The first transfer mechanism is controlled to transfer the standard sample container containing at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample to the first container carrier; The control vehicle scheduling mechanism schedules the first container carrier, which is loaded with the standard sample container and the standard sample container is loaded with at least a portion of the liquid standard sample formed by reconstitution of the lyophilized standard sample, from the reconstitution device to the transmission device; The control system will transfer the first container carrier, which is scheduled to be on the transmission device by the carrier scheduling mechanism, to the sample measuring device. The sample measuring device is controlled to draw at least a portion of the liquid standard sample contained in the standard sample container and dispense it into the first reaction container. The sample measuring device is then controlled to measure the first reaction solution in the first reaction container, which is at least made from the liquid standard sample dispensed into the first reaction container, to obtain the reference detection data.

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