Intraocular lens with adjustable optical member portions and methods of postorally

Abstract

Adjustable intraocular lenses and methods for post-operative adjustment of intraocular lenses are disclosed. In one embodiment, an adjustable intraocular lens (100) may include an optic portion (102) and one or more tabs (104). The optic portion (102) may include a front element (106), a rear element (108), and a fluid-filled optic chamber (110). At least a portion of the optic portion (102) may be made of a composite material. A base power of the optic portion (102) may be configured to vary in response to external energy being directed at the composite material.

Description

Cross-reference to related applications

[0001] This application claims priority to U.S. Patent Application No. 63 / 586,533, filed September 29, 2023, the contents of which are incorporated herein by reference in their entirety. Technical Field

[0002] This disclosure generally pertains to the field of intraocular lenses, and more specifically to intraocular lenses having adjustable optical components and methods for adjusting such intraocular lenses postoperatively. Background Technology

[0003] Cataracts are a condition involving the clouding of the normally clear lens of the eye. Cataracts can occur due to aging, genetic factors, trauma, inflammation, metabolic disorders, or exposure to radiation. Age-related cataracts are the most common type. To treat cataracts, doctors remove the lens matrix from the eye's lens capsule and replace it with an intraocular lens (IOL).

[0004] However, current IOL surgery may leave some patients dissatisfied with their refractive results. In some cases, preoperative biometry of the patient's eye may be inaccurate, resulting in the implantation of an IOL with the wrong lens power. In other cases, excessive healing of the tissues within the capsular bag once the IOL is implanted can affect its optical power. Furthermore, the patient's cornea or the muscles within the eye may have changed due to injury, disease, or aging. In such cases, it may be necessary to adjust the implanted IOL to account for these changes.

[0005] Therefore, a solution is needed that allows for post-implantation adjustment of the IOL to address the aforementioned issues without requiring additional surgery. This solution should not be overly complex and should still allow for cost-effective IOL manufacturing. Summary of the Invention

[0006] This document discloses an adjustable intraocular lens and a method for adjusting the intraocular lens postoperatively. In some embodiments, an adjustable intraocular lens including an optical element portion is disclosed. The optical element portion may include an anterior element, a posterior element, and an optical element chamber defined therebetween. The optical element chamber may be filled with fluid. At least a portion of the posterior element may be made of a composite material. The fundamental power of the optical element portion may be configured to vary in response to external energy directed to the composite material.

[0007] In some embodiments, the rear element may include a first rear portion and a second rear portion. The first rear portion and the second rear portion may be made of a composite material.

[0008] In some embodiments, the second rear portion may be located radially inside the first rear portion.

[0009] In some embodiments, the second rear portion may be located behind the first rear portion.

[0010] In some embodiments, the second rear portion may be located radially inside the first rear portion and behind the first rear portion.

[0011] In some embodiments, the base focal length of the optical component can be configured to decrease in response to external energy directed to the first rear portion.

[0012] In some embodiments, the first rear portion may be configured to expand in response to external energy directed to the first rear portion. Expansion of the first rear portion may increase the volume of the optical chamber.

[0013] In some embodiments, the base focal length of the optical component portion can be configured to increase in response to external energy directed to the second rear portion.

[0014] In some embodiments, the base focal length of the optical component can be configured to decrease in response to external energy directed to the first rear portion, and the base focal length of the optical component can be configured to increase in response to external energy directed to the second rear portion.

[0015] In some embodiments, the second rear portion can be configured to expand in response to external energy directed to it. Expansion of the second rear portion can reduce the volume of the optical chamber.

[0016] In some embodiments, a first rear portion may be configured to expand in response to external energy directed to the first rear portion, and a second rear portion may be configured to expand in response to external energy directed to the second rear portion.

[0017] In some embodiments, the first rear portion may be in the form of a first annular segment. The second rear portion may be in the form of a second annular segment.

[0018] In some embodiments, the diameter of the second annular segment may be smaller than the diameter of the first annular segment.

[0019] In some embodiments, the second annular segment may be positioned concentric with the first annular segment and radially inside the first annular segment.

[0020] In some embodiments, the rear element may include an outer rear surface and an inner rear surface facing the optical chamber. At least a portion of the inner rear surface may serve as the chamber floor of the optical chamber.

[0021] In some embodiments, the second rear portion may be disposed within the chamber floor.

[0022] In some embodiments, at least a portion of the second rear portion may be configured to expand in a forward direction in response to external energy directed to the second rear portion.

[0023] In some embodiments, the inclined portion of the inner rear surface can be used as part of the chamber wall of the optical component chamber.

[0024] In some embodiments, the first rear portion may be disposed within an inclined portion of the inner rear surface.

[0025] In some embodiments, at least a portion of the first rear portion may be configured to expand in a radially outward direction in response to external energy directed to the first rear portion.

[0026] In some embodiments, at least a portion of the second rear portion disposed within the chamber floor can be configured to expand in a forward direction in response to external energy directed to the second rear portion, and at least a portion of the first rear portion disposed within the inclined portion of the inner rear surface can be configured to expand in a radially outward direction in response to external energy directed to the first rear portion.

[0027] In some embodiments, the rear element may further include a raised periphery.

[0028] In some embodiments, the first rear portion may be disposed within the protruding periphery of the rear element.

[0029] In some embodiments, at least a portion of the first rear portion may be configured to expand in response to external energy directed to the first rear portion. Expansion of the first rear portion may increase the volume of the optical chamber.

[0030] In some embodiments, a first rear portion may be disposed within the protruding periphery of a rear element, and a second rear portion may be disposed within the chamber bottom plate of a rear element.

[0031] In some embodiments, the front element may be bonded or adhered to the rear element by an adhesive layer. The adhesive layer may also comprise a composite material.

[0032] In some embodiments, at least a portion of the rear element may be made of a composite material, and at least a portion of the adhesive layer may also comprise a composite material. The base power of the optical portion may be configured to increase in response to external energy directed to the composite material within the rear element, and the base power of the optical portion may be configured to decrease in response to external energy directed to the adhesive layer.

[0033] In some embodiments, the adhesive layer can be configured to expand in response to external energy directed to it. This expansion of the adhesive layer can increase the volume of the optical cavity.

[0034] In some embodiments, the base focal length of the optical component can be configured to decrease in response to external energy directed to the adhesive layer.

[0035] In some embodiments, the composite material within the rear element can be configured to expand in response to external energy directed to the composite material within the rear element. This expansion of the composite material within the rear element can reduce the volume of the optical cavity.

[0036] In some embodiments, the base focal length of the optical component can be configured to increase in response to external energy directed to the composite material within the rear element.

[0037] In some embodiments, a portion of the rear element may serve as a chamber wall surrounding the optical element chamber. The rear element may further include a circular edge extending radially inward from the chamber wall. The circular edge may be made of a composite material.

[0038] In some embodiments, at least a portion of the circular edge may be configured to expand in a radially inward direction in response to external energy directed to the circular edge.

[0039] In some embodiments, the expansion of the circular edge can reduce the volume of the optical cavity and increase the base power of the optical portion. In these and other embodiments, at least a portion of the adhesive layer may further comprise a composite material, wherein the base power of the optical portion is configured to decrease in response to external energy directed to the adhesive layer, and / or at least a portion of the rear element may be made of the composite material, and the base power of the optical portion may be configured to increase in response to external energy directed to the composite material within the rear element. In some embodiments, the composite material may include an energy-absorbing component and a plurality of expandable components.

[0040] In some embodiments, the expandable component may be expandable microspheres.

[0041] In some embodiments, the energy-absorbing component may be an energy-absorbing colorant. For example, the composite material may include expandable microspheres as an expandable component and an energy-absorbing colorant as an energy-absorbing component.

[0042] In some embodiments, the external energy may be a laser with a wavelength between about 488 nm and about 650 nm.

[0043] In some embodiments, the external energy may be a laser with a wavelength between about 946 nm and about 1120 nm.

[0044] In some embodiments, the base power of the optical component may be configured to vary by a total of about 0.05 D to about 3.0 D in response to a pulse of external energy directed to the composite material. In some embodiments, the base power of the optical component may be configured to vary by a total of about 0.05 D to about 3.0 D in response to a pulse of external energy directed to the composite material within the rear element, which forms part of a circular edge and / or part of an adhesive layer.

[0045] In some embodiments, the front element may include an external optical surface. The external optical surface may include a diffraction surface profile or pattern defined on the external optical surface.

[0046] In some embodiments, the adjustable intraocular lens may further include one or more loops extending from the optical portion.

[0047] In some embodiments, a method for adjusting an intraocular lens after implantation is disclosed. The method may include directing external energy to a composite material portion of a posterior element constituting an optical element portion of the intraocular lens. The optical element portion may further include an anterior element and an optical element chamber defined between the anterior and posterior elements. The optical element chamber may be filled with fluid. The fundamental power of the optical element portion may be configured to vary in response to the directing of external energy to the composite material. The method may also include measuring the change in fundamental power of the optical element portion after the external energy is directed to the composite material.

[0048] In some embodiments, the rear element may include a first rear portion and a second rear portion. The first rear portion and the second rear portion may be made of a composite material.

[0049] In some embodiments, the second rear portion may be located radially inside the first rear portion.

[0050] In some embodiments, the second rear portion may be located behind the first rear portion.

[0051] In some embodiments, the method may further include directing external energy to the first rear portion in order to reduce the base focal length of the optical portion.

[0052] In some embodiments, the first rear portion may be configured to expand in response to external energy directed to the first rear portion. Expansion of the first rear portion may increase the volume of the optical chamber.

[0053] In some embodiments, the method may further include directing external energy to the second rear portion in order to increase the base focal length of the optical portion.

[0054] In some embodiments, the second rear portion can be configured to expand in response to external energy directed to it. Expansion of the second rear portion can reduce the volume of the optical chamber.

[0055] In some embodiments, the first rear portion may be in the form of a first annular segment, and the second rear portion may be in the form of a second annular segment.

[0056] In some embodiments, the diameter of the second annular segment may be smaller than the diameter of the first annular segment.

[0057] In some embodiments, the second annular segment may be positioned concentric with the first annular segment and radially inside the first annular segment.

[0058] In some embodiments, the rear element may include an outer rear surface and an inner rear surface facing the optical chamber. At least a portion of the inner rear surface may serve as the chamber floor of the optical chamber.

[0059] In some embodiments, the second rear portion may be disposed within the chamber floor.

[0060] In some embodiments, the method may include directing external energy to a second rear portion within the chamber floor. At least a portion of the second rear portion may be configured to expand in a forward direction in response to the directing of external energy to the second rear portion within the chamber floor.

[0061] In some embodiments, the inclined portion of the inner rear surface can be used as part of the chamber wall of the optical component chamber.

[0062] In some embodiments, the first rear portion may be disposed within an inclined portion of the inner rear surface.

[0063] In some embodiments, the method may further include directing external energy to a first rear portion within an inclined portion of the inner rear surface. At least a portion of the first rear portion may be configured to expand in a radially outward direction in response to the external energy being directed to the first rear portion within the inclined portion of the inner rear surface.

[0064] In some embodiments, the rear element may further include a raised periphery.

[0065] In some embodiments, the first rear portion may be disposed within the protruding periphery of the rear element.

[0066] In some embodiments, the method may include directing external energy to a first rear portion within the periphery of the protrusion. At least a portion of the first rear portion may be configured to expand in response to the directing of external energy to the first rear portion. The expansion of the first rear portion may increase the volume of the optical cavity.

[0067] In some embodiments, the front element may be bonded or adhered to the rear element by an adhesive layer. The adhesive layer may also comprise a composite material.

[0068] In some embodiments, the method may further include directing external energy to the adhesive layer. The adhesive layer may be configured to expand in response to the directing of external energy to the adhesive layer. The expansion of the adhesive layer may increase the volume of the optical cavity.

[0069] In some embodiments, the base focal length of the optical component can be configured to decrease in response to external energy directed to the adhesive layer.

[0070] In some embodiments, the method may further include directing external energy to a composite material within the rear element. The composite material within the rear element may be configured to expand in response to the external energy being directed to it. The expansion of the composite material within the rear element may reduce the volume of the optical cavity.

[0071] In some embodiments, the base focal length of the optical component can be configured to increase in response to external energy directed to the composite material within the rear element.

[0072] In some embodiments, a portion of the rear element may serve as a chamber wall surrounding the optical element chamber. The rear element may further include a circular edge extending radially inward from the chamber wall. The circular edge may be made of a composite material.

[0073] In some embodiments, the method may further include directing external energy to a circular edge. At least a portion of the circular edge may be configured to expand radially inward in response to the external energy being directed to the circular edge. The expansion of the circular edge can reduce the volume of the optical cavity and increase the fundamental focal power of the optical portion.

[0074] In some embodiments, the composite material may include an energy-absorbing component and multiple expandable components.

[0075] In some embodiments, the expandable component may be expandable microspheres.

[0076] In some embodiments, the energy-absorbing component may be an energy-absorbing colorant.

[0077] In some embodiments, the external energy may be a laser with a wavelength between about 488 nm and about 650 nm.

[0078] In some embodiments, the external energy may be a laser with a wavelength between about 946 nm and about 1120 nm.

[0079] In some embodiments, the base focal length of the optical component can be configured to vary by a total of about 0.05 D to about 3.0 D in response to a pulse of external energy directed to the composite material.

[0080] In some embodiments, the front element may include an external optical surface. The external optical surface may include a diffraction surface profile or pattern defined on the external optical surface.

[0081] In some embodiments, the intraocular lens may further include one or more loops extending from the optical portion.

[0082] In some embodiments, an adjustable intraocular lens is disclosed, comprising an optical element portion including an optical element chamber filled with fluid. The optical element chamber may include a chamber floor and chamber walls. At least a portion of the chamber floor may be made of a composite material. The fundamental power of the optical element portion can be configured to vary in response to external energy directed to the chamber floor.

[0083] In some embodiments, the base focal length of the optical component can be configured to increase in response to external energy directed to the chamber floor.

[0084] In some embodiments, at least a portion of the chamber wall may be made of a composite material. The base focal length of the optical components may be configured to vary in response to external energy directed to the chamber wall.

[0085] In some embodiments, the base focal length of the optical component can be configured to decrease in response to external energy directed to the chamber wall.

[0086] In some embodiments, an adjustable intraocular lens is disclosed, comprising an optical element portion including an optical element chamber filled with fluid. At least a portion of the optical element chamber may be made of a composite material. The fundamental power of the optical element portion may be configured to vary in response to external energy directed to the composite material.

[0087] In some embodiments, the optical component portion may include a first optical component portion and a second optical component portion. The first optical component portion and the second optical component portion may be made of composite materials.

[0088] In some embodiments, the second optical element portion may be located radially inside the first optical element portion.

[0089] In some embodiments, the second optical element portion may be located behind the first optical element portion.

[0090] In some embodiments, the base focal length of the optical element portion can be configured to decrease in response to external energy directed to the first optical element portion.

[0091] In some embodiments, the first optical element portion may be configured to expand in response to external energy directed to the first optical element portion. The expansion of the first optical element portion may increase the volume of the optical element chamber.

[0092] In some embodiments, the base focal length of the optical element portion can be configured to increase in response to external energy directed to the second optical element portion. The second optical element portion can be configured to expand in response to external energy directed to the second optical element portion, wherein the expansion of the second optical element portion reduces the volume of the optical element chamber.

[0093] In some embodiments, the first optical element portion may be in the form of a first annular segment. The second optical element portion may be in the form of a second annular segment.

[0094] In some embodiments, the diameter of the second annular segment may be smaller than the diameter of the first annular segment.

[0095] In some embodiments, the second annular segment may be positioned concentric with the first annular segment and radially inside the first annular segment.

[0096] In some embodiments, the optical component portion may include a chamber floor and a chamber wall. A second optical component portion may be disposed within the chamber floor. At least a portion of the second optical component portion may be configured to expand in a forward direction in response to external energy directed to the second optical component portion.

[0097] In some embodiments, at least a portion of the chamber wall may be inclined. A first optical element portion may be disposed within the inclined portion of the chamber wall. At least a portion of the first optical element portion may be configured to expand radially outward in response to external energy directed to the first optical element portion. The expansion of the first optical element portion may increase the volume of the optical element chamber.

[0098] In some embodiments, the optical component may include an adhesive layer. The adhesive layer may include a composite material. The adhesive layer may be configured to expand in response to external energy directed to it. The expansion of the adhesive layer may increase the volume of the optical component chamber. The fundamental power of the optical component may be configured to decrease in response to external energy directed to the adhesive layer.

[0099] In some embodiments, the optical component portion may include a chamber wall surrounding the optical component cavity. The optical component portion may include a circular edge extending radially inward from the chamber wall. The circular edge may be made of a composite material. At least a portion of the circular edge may be configured to expand radially inward in response to external energy directed to the circular edge. The expansion of the circular edge may reduce the volume of the optical component cavity and may increase the fundamental focal power of the optical component portion.

[0100] In some embodiments, the composite material may include an energy-absorbing component and multiple expandable components.

[0101] In some embodiments, the expandable component may be expandable microspheres.

[0102] In some embodiments, the energy-absorbing component may be an energy-absorbing colorant.

[0103] In some embodiments, the external energy may be a laser with a wavelength between about 488 nm and about 650 nm.

[0104] In some embodiments, the external energy may be a laser with a wavelength between about 946 nm and about 1120 nm.

[0105] In some embodiments, the base focal length of the optical component can be configured to vary by a total of about 0.05 D to about 3.0 D in response to a pulse of external energy directed to the composite material.

[0106] In some embodiments, the optical component may include an external optical surface. The external optical surface may include a diffraction surface profile or pattern defined on the external optical surface.

[0107] In some embodiments, the adjustable intraocular lens may further include one or more loops extending from the optical portion. Attached Figure Description

[0108] Figure 1 An exploded perspective view of one embodiment of an adjustable intraocular lens (IOL) is shown.

[0109] Figure 2A The composite material used to manufacture at least a portion of the adjustable IOL is shown.

[0110] Figure 2B An example of an expandable component of a composite material is shown.

[0111] Figure 3 A cross-sectional view of the optical component portion of one embodiment of an adjustable IOL is shown.

[0112] Figure 4A This is a black-and-white image of the optical component of an embodiment of an adjustable IOL after a laser pulse (in this case, external energy) has been directed to the composite material that forms part of the optical component.

[0113] Figure 4B This is a black-and-white image of the optical component of another embodiment of the adjustable IOL after a laser pulse (in this case, external energy) has been directed to the composite material that forms part of the optical component.

[0114] Figure 4C It is a close-up black and white image showing the activated composite material expanding into the optical chamber in response to external energy being directed to the composite material.

[0115] Figure 4D The image is a computed tomography (CT) scan showing that the activated composite material forms part of the chamber wall surrounding the optical component chamber.

[0116] Figure 5 A cross-sectional view of the optical component portion of another embodiment of an adjustable IOL is shown.

[0117] Figure 6 This is an image showing the results of a finite element analysis (FEA) performed on an embodiment of the adjustable IOL after a laser pulse was directed to the composite material of the adjustable IOL.

[0118] Figure 7 A cross-sectional view of the optical component portion of yet another embodiment of an adjustable IOL is shown, wherein the adhesive layer comprises a composite material.

[0119] Figure 8 This demonstrates the effect after a laser pulse is directed to an adhesive layer partially made of composite material. Figure 7 Images of the results of finite element analysis (FEA) performed by the adjustable IOL.

[0120] Figure 9A A cross-sectional view of the optical component portion of an embodiment of an adjustable IOL is shown, wherein the composite material extends radially inward from the chamber wall of the adjustable IOL.

[0121] Figure 9B This demonstrates what happens after a laser pulse is guided to a composite material extending radially inward from the chamber wall of an adjustable IOL. Figure 9A A cross-sectional view of the optical components of an adjustable IOL.

[0122] Figures 10A to 10C Various methods for adjusting the IOL after surgery or implantation are demonstrated. Detailed Implementation

[0123] Figure 1 An exploded perspective view of one embodiment of an adjustable intraocular lens (IOL) 100 is shown. Figure 1 The depicted adjustable IOL 100 may include an optical element portion 102 and one or more loops 104 extending from the optical element portion 102.

[0124] The loop 104 may include a first loop and a second loop extending circumferentially from or connected to the optical component portion 102. Each of the loops 104 may include a bend or flexure defined along an arm of the loop 104. The bend or flexure may allow the loop 104 to compress or flex in response to a change in the shape of the pouch. Each of the loops 104 may terminate at a free or unconnected distal end.

[0125] For example, the adjustable IOL 100 can be a one-piece lens, such that the loop 104 is connected to and extends from the optical element portion 102. In this exemplary embodiment, the loop 104 is formed together with the optical element portion 102, rather than being adhered to or otherwise coupled to the optical element portion 102 in a subsequent step.

[0126] In other embodiments, loops 104 may be coupled to and adhered to optical portion 102. For example, loops 104 may be adhered to optical portion 102 after each loop is formed individually.

[0127] The optical component portion 102 may include a front element 106, a rear element 108, and an optical component cavity 110 defined between the front element 106 and the rear element 108. The optical component cavity 110 (see also, for example...) Figure 3 , Figure 5 , Figure 7 , Figure 9A and Figure 9B It can be filled with fluid.

[0128] In some embodiments, the fluid within the optical component chamber 110 may be oil. More specifically, in some embodiments, the fluid within the optical component chamber 110 may be silicone oil.

[0129] At least a portion of the rear element 108 may be made of or comprise composite material 103. As will be discussed in more detail in the following sections, composite material 103 may include energy-absorbing component 204 and multiple expandable components 206 (see, for example...). Figure 2A and Figure 2B ).

[0130] like Figure 1 As shown, in some embodiments, the composite material 103 may be formed as a ring or a plurality of concentric rings (wherein the concentric rings are connected to each other or not connected).

[0131] In some embodiments, portions of the rear element 108 may be shaped or otherwise formed (e.g., by lathe tools or cutting tools) to accommodate the composite material 103. In these and other embodiments, the composite material 103 may be coupled to or adhered to the remainder of the rear element 108. For example, one or more circular grooves or cutouts may be formed along the front portion of the rear element 108. In this example, the grooves or cutouts may be filled with the composite material 103.

[0132] In some embodiments, the rear element 108 may be cast and cured together with the composite material 103. In these embodiments, the composite material 103 may be integral with the rear element 108 or formed along the interior of the rear element 108.

[0133] As will be discussed in more detail in later chapters, composite material 103 can be configured to expand in response to external energy directed to or otherwise applied to composite material 103. Expansion of composite material 103 can cause a change in the volume of optical chamber 110 (or the available volume for retaining fluid within optical chamber 110).

[0134] Depending on the position of the composite material 103 within the rear element 108, the expansion of the composite material 103 can increase or decrease the volume of the optical cavity 110.

[0135] Furthermore, as will be discussed in more detail in later sections, the base focal length of the optical component can be configured to vary in response to any change in the volume of the optical cavity 110 caused by external energy directed to the composite material 103. For example, the front element 106 of the optical component 102 can flex or deform (or otherwise change shape or curvature) in response to changes in fluid pressure within the optical cavity 110 due to changes in the volume of the optical cavity 110. In some embodiments, at least a portion of the rear element 108 can also flex or deform (or otherwise change shape or curvature) in response to changes in fluid pressure within the optical cavity 110.

[0136] The base power or optical / refractive power of the optical component 102 can be configured to change when the front element 106 and / or the rear element 108 flex or deform in response to changes in fluid pressure within the optical component chamber 110 caused by external energy directed to the composite material 103.

[0137] In some embodiments, directing external energy to a portion of the rear element 108 made of composite material 103 can cause that particular portion of the rear element 108 to change its shape or expand, without substantially affecting the other portions of the rear element 108.

[0138] Furthermore, as will be discussed in more detail in the following sections, directing a pulse of external energy to a portion of the rear element 108 can cause a change in the fundamental focal length of the optical portion 102 in one direction (e.g., an increase in fundamental focal length). In these embodiments, directing an additional pulse of external energy to another portion of the rear element 108 can cause a change in the fundamental focal length of the optical portion 102 in another direction (e.g., a decrease in fundamental focal length).

[0139] In some embodiments, the base power of the optical component 102 can be configured to change by a total of about 0.05 diopters (D) to about 3.0 D (e.g., about 2.0 D) in the positive or negative direction in response to external energy (e.g., a laser pulse) directed to the composite material 103 within the optical component 102.

[0140] The change in the base power of the optical component 102 can be a persistent or substantially permanent change. A persistent or substantially permanent change can mean that the composite material 103 will not substantially return to its original shape or size after the change.

[0141] In some embodiments, the optical component portion 102 may have an unfilled or factory power of approximately 11 D to 13 D (i.e., the power of the optical component portion 102 when the optical component cavity 110 is empty or unfilled) (i.e., a "zero-power" lens). For example, the optical component portion 102 may have an unfilled or factory power of approximately 12 D. The power of the optical component portion 102 may increase as the optical component cavity 110 is filled with a fluid (e.g., silicone oil).

[0142] The optical cavity 110 can be filled until the fundamental focal power of the filled optical portion 102 (contributed by both the fluid in the optical portion 102 and the lens surface) is between about 15 D (low focal power IOL) and about 30 D (high focal power IOL). For example, the optical cavity 110 can be filled until the fundamental focal power of the filled optical portion 102 is about 20 D.

[0143] The adjustable IOL 100 implanted within the subject's pocket can have a base power between approximately 15 D and approximately 30 D (e.g., approximately 20 D). When the adjustable IOL 100 is implanted within the subject's pocket, a clinician or medical professional can direct external energy (e.g., a laser pulse) to the composite material 103 within the optics portion 102 to increase or decrease the base power of the optics portion 102.

[0144] For example, the adjustable IOL 100 can have a base power of approximately 20 D when implanted in a subject's eye. If it is desired to perform power correction to increase the lens power, a clinician or medical professional can direct external energy to the composite material 103 that forms part of the optics portion 102 to increase the base power of the optics portion 102 until the final base power is at the desired base power.

[0145] As another example, the adjustable IOL 100 can have a base power of approximately 25 D when implanted in a subject's eye. If it is desired to perform power correction to reduce the lens power, a clinician or medical professional can direct external energy to another instance of the composite material 103 that forms part of the optics portion 102 to reduce the base power of the optics portion 102 until the final base power is at the desired base power.

[0146] In some embodiments, the adjustable IOL 100 may be designed or configured such that when the adjustable IOL 100 is implanted in the capsule, the base power of the optical portion 102 may be unresponsive or insensitive to forces applied by the capsule to one or more loops 104.

[0147] In some embodiments, the external energy can be light energy. More specifically, the external energy can be laser energy. The external energy can be a burst laser or a laser pulse.

[0148] In some embodiments, the laser may have a wavelength between about 488 nm and about 650 nm. For example, the laser may be a green laser. A green laser may have a wavelength between about 520 nm and about 570 nm. In one exemplary embodiment, the external energy may be a green laser with a wavelength of about 532 nm.

[0149] For example, the laser could be emitted by an ophthalmic laser. For example, the laser could be emitted by a retinal photocoagulation laser.

[0150] In some embodiments, the laser can be emitted by a neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. As a more specific example, the laser can be a pulsed Nd:YAG laser operating in Q-switched mode and frequency-doubled to produce a 532 nm laser.

[0151] In other embodiments, the laser can be emitted by a femtosecond laser or an infrared or near-infrared laser. For example, laser emitted by such a laser can have a wavelength between about 1030 nm and 1064 nm.

[0152] As will be discussed in more detail in the following sections, when the external energy is light energy, the energy-absorbing components within composite material 103 (see...) Figure 2A It can absorb or otherwise capture light energy and convert it into heat energy and transfer it to the expandable component within composite material 103 (see...). Figure 2A and Figure 2B This allows the expandable component to expand.

[0153] Figure 1 It is also shown that the front element 106 may include an external optical surface 111. The external optical surface 111 may include a unique lens surface profile 115 or pattern defined on the external optical surface 111.

[0154] In some embodiments, the lens surface profile 115 may include a central diffraction region or structure comprising a plurality of diffraction zones or steps. In these and other embodiments, the width of the diffraction zone may decrease radially outward, such that the zone width at the periphery of the lens is smaller than the zone width near the central portion of the lens.

[0155] In some embodiments, the lens surface profile 115 can split light into multiple focal points. In these embodiments, the adjustable IOL 100 can be considered an adjustable multifocal IOL.

[0156] In some embodiments, the lens surface profile 115 can be configured to split light into two focal points (e.g., allowing near and far vision). In these embodiments, the adjustable IOL 100 can be considered an adjustable bifocal IOL.

[0157] The lens surface profile 115 can also be configured to split light into three focal points (e.g., allowing near, intermediate, and far vision). In these embodiments, the adjustable IOL 100 can be considered an adjustable trifocal IOL.

[0158] exist Figure 1 In other embodiments not shown, the external optical surface 111 may have a uniformly curved (e.g., spherical) lens surface, or an aspherical lens surface that provides focusing power for a single distance. In these embodiments, the adjustable IOL 100 can be considered an adjustable monofocal IOL.

[0159] exist Figure 1 In additional embodiments not shown, the external optical surface 111 may have a lens surface profile or pattern configured to provide extended depth of focus or a single elongated focal point. In these embodiments, the adjustable IOL 100 may be considered an adjustable extended depth of focus (EDOF) IOL or a non-adjustable fluid-adjustable EDOFIOL.

[0160] In addition, any of the adjustable monofocal IOL, adjustable multifocal IOL, and EDOF IOL may include a toroidal lens profile.

[0161] One technical challenge faced by the applicant is how to design an adjustable fluid-filled IOL that can be used by patients seeking different types of vision support (e.g., near vision, intermediate vision, distance vision, etc.). One solution discovered by the applicant is the adjustable IOL disclosed herein, in which different lens surface profiles (including both rotationally symmetric and toric profiles) can be defined on the external optical surface 111 of the optics portion 102, thereby allowing the same adjustable IOL structure to be adapted as an adjustable monofocal IOL, an adjustable bifocal IOL, an adjustable trifocal IOL, or an adjustable EDOFIOL, while simultaneously supporting toric and non-toric shapes.

[0162] The uncompressed loop length of the adjustable IOL 100 can be measured from the distal end of the first loop to the distal end of the second loop. The uncompressed loop length can be between approximately 12.0 mm and approximately 14.0 mm. For example, the uncompressed loop length can be approximately 13.0 mm.

[0163] In some embodiments, the optical component portion 102 may have an optical component portion diameter. The optical component portion diameter may be between about 5.0 mm and 8.0 mm. For example, the optical component portion diameter may be about 6.0 mm.

[0164] In some embodiments, portions of the optical element portion 102 not made of composite material 103 may include or be partially made of lens body material. Lens body material may be partially made of a crosslinked copolymer comprising copolymer blends. Copolymer blends may include alkyl acrylates or alkyl methacrylates, fluoroalkyl (meth)acrylates, and phenylalkyl acrylates. This disclosure contemplates, and will be understood by those skilled in the art, that these types of crosslinked acrylic copolymers may generally be copolymers of various acrylates, methacrylates, or combinations thereof, and unless otherwise specified, the term "acrylate" as used herein may be understood to interchangeably refer to acrylates, methacrylates, or combinations thereof.

[0165] The crosslinked copolymer used to make the lens body material may include about 3% to 20% (by weight) of alkyl acrylate or methyl acrylate, about 10% to 35% (by weight) of fluoroalkyl acrylate or fluoroalkyl methyl acrylate, and about 50% to 80% (by weight) of phenylalkyl acrylate. In some embodiments, the crosslinked copolymer may include or be partially composed of: n-butyl acrylate as an alkyl acrylate, trifluoroethyl methacrylate as a fluoroalkyl acrylate, and phenylethyl acrylate as a phenylalkyl acrylate. More specifically, the crosslinked copolymer used to make the lens body material may include about 3% to 20% (by weight) (e.g., between about 12% and 16%) of n-butyl acrylate, about 10% to 35% (by weight) (e.g., between about 17% and 25%) of trifluoroethyl methacrylate, and about 50% to 80% (by weight) (e.g., between about 64% and 67%) of phenylethyl acrylate.

[0166] The final composition of the crosslinked copolymer used to manufacture the lens body material may also include a crosslinker or crosslinking agent, such as ethylene glycol dimethacrylate (EGDMA) and a hydroxyl-functionalized acrylic monomer (hydroxyethyl acrylate (HEA) or hydroxyethyl methacrylate (HEMA)). For example, the final composition of the crosslinked copolymer used to manufacture the lens body material may also include about 1.0% of a crosslinker or crosslinking agent (e.g., EGDMA). The final composition of the crosslinked copolymer used to manufacture the lens body material may also include an initiator or initiator (e.g., Perkadox 16, Darocur, etc.) and a UV absorber.

[0167] Loop 104 may include or be partially made of loop material. The loop material may include or be partially made of crosslinked copolymers, which include copolymer blends. Copolymer blends may include alkyl acrylates, fluoroalkyl acrylates, and phenylalkyl acrylates. For example, the crosslinked copolymer used to make the loop material may include about 10% to 25% (by weight) of alkyl acrylates, about 10% to 35% (by weight) of fluoroalkyl acrylates, and about 50% to 80% (by weight) of phenylalkyl acrylates. In some embodiments, the crosslinked copolymer used to make the loop material may include about 10% to 25% (by weight) (e.g., between about 19% and about 23%) of n-butyl acrylate, about 10% to 35% (by weight) (e.g., between about 14% and about 18%) of trifluoroethyl methacrylate, and about 50% to 80% (by weight) (e.g., between about 58% and about 62%) of styrene acrylate. The final composition of the crosslinked copolymer used to make the loop material may also include about 1.0% of a crosslinker or crosslinking agent, such as EGDMA. The final composition of the crosslinked copolymer used to make the loop material may also include several photoinitiators or photoinitiators (e.g., camphorquinone, 1-phenyl-1,2-propanedione, 2-ethylhexyl-4-(dimethylamino)benzoate, etc.).

[0168] In some embodiments, the refractive index of the lens body material may be between about 1.48 and about 1.53. In some embodiments, the refractive index of the lens body material may be between about 1.50 and about 1.53 (e.g., about 1.5178).

[0169] The optical component 102 can be configured to deform, flex, or otherwise change shape in response to changes in fluid pressure within the optical component chamber 110. The fluid pressure within the optical component chamber 101 can change because the volume of the optical component chamber 110 changes due to the expansion of the composite material 103.

[0170] As previously discussed, the fluid within the optical component chamber 110 may be silicone oil. In some embodiments, the silicone oil may comprise, or be partially comprised of, a ratio of two dimethylsiloxane units to one diphenylsiloxane unit. In some embodiments, the silicone oil may comprise about 20 mol% diphenylsiloxane and about 80 mol% dimethylsiloxane.

[0171] More specifically, in some embodiments, the silicone oil may comprise diphenyltetramethylcyclotrisiloxane. In additional embodiments, the silicone oil may comprise a copolymer of diphenylsiloxane and dimethylsiloxane or be partially made of a copolymer of diphenylsiloxane and dimethylsiloxane.

[0172] A fluid (e.g., silicone oil) can be refractively matched to the lens body material used to fabricate the optical component portion 102. When the fluid is refractively matched to the lens body material, the entire optical component portion 102 containing the fluid acts as a single lens. For example, the fluid can be selected such that it has a refractive index between about 1.48 and 1.53 (or between about 1.50 and 1.53).

[0173] In some embodiments, the fluid (e.g., silicone oil) may have a polydispersity index between about 1.2 and 1.3. In other embodiments, the fluid (e.g., silicone oil) may have a polydispersity index between about 1.3 and 1.5. In other embodiments, the fluid (e.g., silicone oil) may have a polydispersity index between about 1.1 and 1.2. Other exemplary fluids are described in U.S. Patent No. 8,900,298, the contents of which are incorporated herein by reference in their entirety.

[0174] The IOL 100 can be implanted within a native capsular bag where the native lens has been removed. When implanted within the native capsular bag, the optic portion 102 can be adapted to refract light entering the eye onto the retina. One or more loops 104 can be configured to engage the capsular bag to hold the adjustable IOL 100 in the appropriate position within the capsular bag.

[0175] Figure 2A This is a graphic representation of composite material 103, which includes a composite substrate 202, an energy-absorbing component 204, and a plurality of expandable components 206. As previously discussed, one or more portions of the optical component portion 102 may be made of composite material 103.

[0176] The composite substrate 202 may be composed of a hydrophobic acrylic material. For example, the composite substrate 202 may be composed of styrene acrylate (PEA), styrene methacrylate (PEMA), or a combination thereof.

[0177] In one exemplary embodiment, the composite substrate 202 may include a methacrylate-functionalized or methacrylate-functionalized crosslinkable polymer and a reactive acrylic monomer diluent, the reactive acrylic monomer diluent including lauryl methacrylate (dodecyl methacrylate or SR313) and ADMA. By controlling the amount of lauryl methacrylate (SR313) relative to ADMA, the overall corresponding hardness (i.e., more ADMA) or softness (i.e., more SR313) of the cured composite material 103 can be controlled. The methacrylate-functionalized or methacrylate-functionalized crosslinkable polymer can be prepared using a crosslinkable polymer precursor formulation.

[0178] Crosslinkable polymer precursor formulations may include the same copolymer blends used to make optical parts 102 and loops 104.

[0179] The copolymer blend may include alkyl acrylates or alkyl methacrylates (e.g., n-butyl acrylate), fluoroalkyl (meth)acrylates (e.g., trifluoroethyl methacrylate), and phenylalkyl acrylates (e.g., ethyl styrene). For example, the copolymer blend may include about 41% to about 45% (by weight) of n-butyl acrylate, about 20% to about 24% (by weight) of trifluoroethyl methacrylate, and about 28% to about 32% (by weight) of ethyl styrene. Crosslinkable polymer precursor formulations may include copolymer blends, hydroxy-functionalized acrylic monomers (e.g., HEA), and photoinitiators (e.g., Darocur 4265 or a 50 / 50 blend of diphenyl(2,4,6-trimethylbenzoyl)-phosphine oxide and 2-hydroxy-2-methylphenylacetone) or partially thereof.

[0180] The composite substrate 202 may include about 50% to about 65% (e.g., about 55% to about 60%) (by weight) of methacrylate functional groups or methacrylate functional group crosslinkable polymers (as discussed above), about 32% to about 38% (e.g., about 32.70%) (by weight) of reactive acrylic monomer diluent lauryl methacrylate (SR313), and about 5% to about 9% (e.g., about 7.30%) (by weight) of reactive acrylic monomer diluent adamantyl methacrylate (ADMA).

[0181] Table 1 below provides an exemplary formulation for composite material 103: Table 1: Formulation of composite materials (by weight percentage)

[0182] The composite material 103 can be manufactured in several operations. A first operation may include preparing an uncolored composite substrate 202. A second operation may include mixing the composite substrate 202 with an energy-absorbing component 204, an expandable component 206, and an initiator such as one or more photoinitiators, thermal initiators, or combinations thereof. A third operation may include placing the uncured composite material 103 into a desired position within the optical component portion 102 and curing the composite material 103 into place.

[0183] For example, the uncolored composite substrate 202 can be mixed with an energy-absorbing component 204, such as a dye (e.g., Disperse Red 1 dye) or a pigment (graphitized carbon black). The energy-absorbing component 204 will be discussed in more detail below.

[0184] In some embodiments, the expandable component 206 may comprise about 5.0% to about 15.0% by weight of the final formulation of composite material 103. More specifically, the expandable component 206 may comprise about 8.0% to about 12.0% (e.g., about 10.0%) by weight of the final formulation of composite material 103 (see Table 1). In these and other embodiments, the energy-absorbing component 204 may comprise about 0.044% to about 0.44% (or about 0.55%) by weight of the final formulation of composite material 103.

[0185] The photoinitiator may be Omnirad 2022 (bis(2,4,6-trimethylbenzoyl)phenylphosphine oxide / 2-hydroxy-2-methyl-1-phenyl-1-propanone). The photoinitiator may comprise about 1.30% by weight of the final formulation of composite material 103 (see, for example, Table 1). Additionally, composite material 103 may also include a thermal initiator. The thermal initiator may comprise about 1.00% by weight of the final formulation of composite material 103 (see, for example, Table 1). In some embodiments, the thermal initiator may be a dialkyl peroxide, such as Luperox® peroxide. In other embodiments, the thermal initiator may be Perkadox.

[0186] In some embodiments, the energy-absorbing component 204 can absorb external energy (e.g., laser energy), convert the energy into heat, and conduct the energy to the composite substrate 202 to cause the composite substrate 202 to expand.

[0187] Figure 2B It is shown that the expandable component 206 can be expandable microspheres, which include an expandable thermoplastic shell 208 and a blowing agent 210 contained within the expandable thermoplastic shell 208. The microspheres can be configured to expand such that the diameter 212 of at least one microsphere can increase by about 2 times the original diameter. In other embodiments, the microspheres can be configured to expand such that the diameter 212 of at least one microsphere increases by about 4 times or four times the original diameter. In yet another embodiment, the microspheres can be configured to expand such that the diameter 212 of at least one microsphere can increase by between about 2 times and about 4 times (or about 3.5 times) the original diameter. For example, the microspheres may initially have a diameter 212 of about 12 µm. In response to energy applied to or directed to the composite material 103 or in response to energy transferred or transported to the microspheres, the diameter 212 of the microspheres can increase to about 40 µm.

[0188] The volume of at least one of the microspheres can be configured to expand by about ten times (10X) to about 50 times (50X) in response to energy applied to or directed to the composite material 103 or in response to energy transferred or transported to the microspheres.

[0189] In some embodiments, the blowing agent 210 may be an expandable fluid, such as an expandable gas. More specifically, the blowing agent 210 may be a branched hydrocarbon. For example, the blowing agent 210 may be isopentane. In other embodiments, the blowing agent 210 may be or include cyclopentane, pentane, or a mixture of cyclopentane, pentane, and isopentane.

[0190] The expandable component 206 may include varying amounts of foaming agent 210. For example, some expandable components 206 may include more or greater amounts of foaming agent (e.g., more expandable gas) to allow the expandable component 206 to expand further, thereby causing the composite material 103 including the expandable component 206 to expand more.

[0191] Figure 2B It is shown that each expandable component 206 may include a thermoplastic shell 208. Figure 2B It was also demonstrated that the thickness of the thermoplastic shell 208 can vary as the size of the expandable component 206 increases. More specifically, the thickness of the thermoplastic shell 208 can decrease as the size of the expandable component 206 increases. For example, when the expandable component 206 is an expandable microsphere, the thickness of the thermoplastic shell 208 (i.e., its thickness in the radial direction) can decrease as the diameter 212 of the expandable microsphere increases.

[0192] For example, as previously discussed, at least one expandable microsphere may initially have a diameter 212 of about 12 µm. In this embodiment, the thermoplastic shell 208 of the expandable microsphere may have a shell thickness of about 2.0 µm. In response to energy applied to or directed to the composite material 103 or in response to energy transferred to or transmitted to the microsphere, the diameter 212 of the microsphere may increase to about 40 µm (and the volume expands by about 10X to 50X), and the shell thickness of the microsphere may decrease to about 0.1 µm.

[0193] although Figure 2A and Figure 2B Expandable component 206 is shown as a sphere or microsphere, but it is envisioned in this disclosure that the shape of expandable component 206 may be substantially oval, elliptical, cubic or other polyhedral, or a combination thereof.

[0194] In some embodiments, the thermoplastic housing 208 may be made in part from a nitrile or an acrylonitrile copolymer. For example, the thermoplastic housing 208 may be made in part from acrylonitrile, styrene, butadiene, methyl acrylate, or a combination thereof.

[0195] As previously discussed, expandable component 206 may comprise between approximately 8.0% and approximately 12% by weight of the final formulation of composite material 103. Expandable component 206 may comprise approximately 10% by weight of the final formulation of composite material 103.

[0196] The expandable component 206 may be dispersed or otherwise distributed in the composite substrate 202 constituting the bulk of the composite material 103. The composite substrate 202 may serve as a matrix for retaining or supporting the expandable component 206. The composite material 103 may expand in response to the expansion of the expandable component 206 (e.g., thermoplastic microspheres). For example, the volume of the composite material 103 may be configured to increase in response to the expansion of the expandable component 206.

[0197] The composite material 103 also includes an energy-absorbing component 204. In some embodiments, the energy-absorbing component 204 may be an energy-absorbing colorant.

[0198] In some embodiments, the energy-absorbing colorant may be an energy-absorbing dye. For example, the energy-absorbing dye may be an azo dye. In some embodiments, the azo dye may be a red azo dye, such as Disperse Red 1. In other embodiments, the azo dye may be an orange azo dye, such as Disperse Orange (e.g., Disperse Orange 1); a yellow azo dye, such as Disperse Yellow (e.g., Disperse Yellow 1); a blue azo dye, such as Disperse Blue (e.g., Disperse Blue 1); or a combination thereof.

[0199] In an additional embodiment, the energy-absorbing colorant may be or may include a pigment. For example, the energy-absorbing colorant may be or may include graphitized carbon black as a pigment.

[0200] Similar to the expandable component 206, the energy-absorbing component 204 can be dispersed or otherwise distributed in the composite substrate 202 that constitutes the main body of the composite material 103. The composite substrate 202 can be used as a matrix to retain or support the expandable component 206 and the energy-absorbing component 204.

[0201] As previously discussed, the energy-absorbing component 204 may comprise between about 0.025% and about 1.0% (or more specifically, about 0.045% and about 0.45%) by weight of the final formulation of composite material 103. For example, when the energy-absorbing component 204 is a dye (e.g., an azo dye such as Disperse Red 1), the energy-absorbing component 204 may comprise between about 0.45% and about 1.0% by weight of the final formulation of composite material 103. When the energy-absorbing component 204 is graphitized carbon black or other types of pigment, the energy-absorbing component 204 may comprise between about 0.025% and about 0.045% by weight of the final formulation of composite material 103.

[0202] Energy-absorbing component 204 (e.g., azo dye, graphitized carbon black, or a combination thereof) can absorb or capture applied or external energy directed to composite material 103 (e.g., light energy or, more specifically, laser energy). Energy-absorbing component 204 can absorb or capture external energy and then convert or transfer the energy into heat or heat to expandable component 206.

[0203] When heat is transferred or transported to the expandable component 206, the thermoplastic shell 208 can soften and begin to flow. The thermoplastic shell 208 of the expandable component 206 can then begin to thin or decrease in thickness in response to the heat transferred or transported to it. As the thermoplastic shell 208 begins to soften and decrease in thickness, the foaming agent 210 within the expandable component 206 can expand. The foaming agent 210 can also expand in response to the heat or heat transferred or transported to the expandable component 206. The expansion of the foaming agent 210 can cause the expandable component 206 (e.g., thermoplastic microspheres) to expand or increase in volume. This ultimately causes the composite material 103 to expand or increase in volume.

[0204] The composite material 103 can expand or increase in size in an isotropic manner, such that the composite material 103 expands in all directions. By placing or positioning the composite material 103 at a specific location within the optical component portion 102 of the adjustable IOL 100, this isotropic expansion can be used to produce expansion or material displacement in a specific direction.

[0205] As previously discussed, the external energy can be a laser, and the energy-absorbing component 204 can absorb or capture the laser light directed to the composite material 103, converting or transferring the light energy into heat energy or heating the expandable component 206. The foaming agent 210 within the expandable component 206 can expand or be excited in response to the heat energy or heat. The expandable component 206 and the final composite material 103 can expand or increase in volume in response to this light energy directed to the composite material 103.

[0206] The shape change (e.g., volume increase) that occurs in the expandable component 206 can be a persistent or substantially permanent change. A persistent or substantially permanent change can mean that the expandable component 206 does not significantly revert to its original shape or size after the shape change has occurred (e.g., after the volume increase). As a result, any change in the size or volume of the composite material 103 caused by a change in the size or volume of the expandable component 206 is also persistent or substantially permanent. As will be discussed in more detail in the following sections, this means that any structural changes to the IOL 100 caused by external energy or stimuli applied to or otherwise directed to the composite material 103 embedded or integrated within the IOL 100 can be persistent or remain substantially permanent.

[0207] When external energy is no longer directed to or applied to the composite material 103, the thermoplastic shell 208 of the expandable component 206 can be hardened again. For example, when the temperature near the expandable component 206 drops below a certain threshold, the thermoplastic shell 208 can be hardened again. For example, when light energy is no longer directed to the composite material 103, the thermoplastic shell 208 of the expandable microspheres can be hardened. After the thermoplastic shell 208 hardens, the expandable component 206 is locked to its new size and expansion configuration.

[0208] When the energy-absorbing component 204 is an energy-absorbing colorant (such as a dye or graphitized carbon), at least a portion of the composite material 103 can exhibit the color of the energy-absorbing colorant. For example, when the energy-absorbing component 204 is an azo dye with red color (such as Disperse Red 1), at least a portion of the composite material 103 including the energy-absorbing component 204 can be colored red. Furthermore, when the energy-absorbing component 204 is graphitized carbon with black color, at least a portion of the composite material 103 including the energy-absorbing component 204 can be colored black. Although two colors (e.g., red and black) are mentioned in this disclosure, it is contemplated in this disclosure and should be understood by those skilled in the art that other types of energy-absorbing colorants, such as energy-absorbing yellow, orange, or blue dyes or materials, can also be used.

[0209] When at least a portion of the IOL 100 is made of a composite material 103 including an energy-absorbing colorant, the color of the energy-absorbing colorant can be visually perceptible to a clinician or another medical professional. When the IOL 100 is implanted in a patient's eye, the color of the energy-absorbing colorant can be visually perceptible to a clinician or another medical professional. For example, the composite material 103 may include Disperse Red 1 as an energy-absorbing colorant. In this example, when the IOL 100 is implanted in a patient's eye, at least a portion of the IOL 100 may appear red or slightly red to a clinician or another medical professional. The color of the energy-absorbing colorant allows a clinician or another medical professional to detect or determine the location or position of the composite material 103 within the IOL 100. The color of the energy-absorbing colorant also allows a clinician or another medical professional to determine where to direct external energy to adjust the IOL 100.

[0210] One technical problem faced by the applicant is how to integrate composite material 103 into the optical component portion 102 of the adjustable IOL 100 such that composite material 103 adheres to the material used to manufacture the rest of the adjustable IOL 100 and remains substantially fixed in certain locations within the optical component portion 102. One solution discovered by the applicant and disclosed herein is the unique composition of composite material 103, which employs the same copolymer blend used to manufacture the rest of the optical component portion 102. By designing the adjustable IOL 100 in this way, composite material 103 can be compatible with the material used to construct the rest of the optical component portion 102 and can remain substantially fixed in its position without migration or displacement.

[0211] Another technical challenge faced by the applicant is ensuring that any adjustments made to the adjustable IOL 100 persist for an extended period after the adjustment procedure. One solution discovered and disclosed herein is to induce expansion of the composite material 103, which is partially composed of expandable microspheres comprising a foaming agent contained within a thermoplastic shell. The thermoplastic shell can soften (and its thickness can decrease) in response to external energy directed to or applied to the composite material 103 (which can induce heat or thermal energy transfer to the expandable microspheres). The foaming agent within the thermoplastic shell can expand as the shell softens. This expansion of the foaming agent causes the microspheres to expand, which in turn expands the composite substrate that serves as the body of the composite material 103. Even after external energy is no longer applied to the composite material 103, the expandable microspheres can retain their new expanded or extended configuration.

[0212] Furthermore, the energy-absorbing component of composite material 103 can capture or absorb a relatively harmless amount of external energy or stimulation directed to composite material 103, and convert or transfer the external energy into heat energy, which can then cause the thermoplastic microspheres to expand. By designing the optical component 102 of the adjustable IOL 100 in this way, a relatively harmless burst of energy or stimulation (e.g., light energy) can be used to cause a persistent change in the shape or size of at least a portion of the optical component 102. This persistent change in the shape or size of the optical component 102 can have a continuous effect on the optical parameters of the lens (e.g., including its fundamental power).

[0213] Figure 3 Showing the assembly configuration Figure 1 This is a cross-sectional view of one embodiment of the optical component 102 of the adjustable IOL 100. In this view, the loop 104 of the adjustable IOL 100 has been removed for easier observation.

[0214] like Figure 3 As shown, the rear element 108 may include a first rear portion 112 and a second rear portion 114. The first rear portion 112 and the second rear portion 114 may be made of composite material 103.

[0215] In some embodiments, the second rear portion 114 may be located radially inside the first rear portion 112. In these and other embodiments, the second rear portion 114 may also be located behind the first rear portion 112.

[0216] like Figure 3 As shown, the rear element 108 may include an outer rear surface 116, an inner rear surface 118 facing the optical chamber 110, and a raised periphery 120. At least a portion of the inner rear surface 118 may serve as a chamber floor 122 of the optical chamber 110. An inclined portion 124 of the inner rear surface 118 may serve as part of a chamber wall 126 surrounding the optical chamber 110.

[0217] In some embodiments, a first rear portion 112 may be disposed within a chamber wall 126, and a second rear portion 114 may be disposed within a chamber floor 122. In these and other embodiments, at least a portion of the chamber floor 122 of the optical component portion 102 may be made of composite material 103, and at least a portion of the chamber wall 126 of the optical component portion 102 may be made of composite material 103.

[0218] like Figure 1 and Figure 3 As shown, in some embodiments, the first rear portion 112 may be implemented in the form of a first annular segment 128 (see [reference]). Figure 1 ), and the second rear portion 114 can be implemented in the form of a second annular segment 130 (see Figure 1 The diameter of the second annular segment 130 can be smaller than the diameter of the first annular segment 128. The second annular segment 130 can be positioned concentrically with the first annular segment 128.

[0219] In some embodiments, the first annular segment 128 (first rear portion 112) and the second annular segment 130 (second rear portion 114) may be connected together, or may be implemented as a large outer ring and a smaller inner ring connected to the large outer ring in a stepped descending manner.

[0220] In other embodiments, the first annular segment 128 (first rear portion 112) may be disconnected from or spaced apart from the second annular segment 130 (second rear portion 114).

[0221] As will be discussed in more detail in the following sections, the base power of the optical component 102 may be configured to decrease in response to external energy (e.g., light energy) directed to the first rear portion 112. Additionally or alternatively, the base power of the optical component 102 may be configured to increase in response to external energy directed to the second rear portion 114.

[0222] The first rear portion 112 can be configured to expand in response to external energy directed to the first rear portion 112. The volume of the optical chamber 110 can increase in response to the expansion of the first rear portion 112.

[0223] The second rear portion 114 can be configured to expand in response to external energy directed to it. The volume of the optical chamber 110 can decrease in response to the expansion of the second rear portion 114. For example, at least a portion of the second rear portion 114 can be configured to expand in the forward direction (into the optical chamber 110) in response to external energy directed to it.

[0224] When the second rear portion 114 is disposed within the chamber floor 122, the base power of the optical portion 102 can be configured to increase in response to external energy directed to the chamber floor 122.

[0225] When the first rear portion 112 is disposed within the chamber wall 126, the base focal length of the optical portion 102 can be configured to decrease in response to external energy directed to the chamber wall 126.

[0226] One technical challenge faced by the applicant is how to design an IOL that can be adjusted postoperatively by clinicians or other medical professionals. One technical solution discovered by the applicant is the adjustable IOL 100 disclosed herein, wherein the optical chamber 110 of the adjustable IOL 100 is filled with a fluid (e.g., silicone oil), and at least a portion of the rear element 108 of the optical portion 102 is made of a composite material 103. The base power of the optical portion 102 can be configured to vary in response to external energy directed to the composite material 103.

[0227] Figure 4A This is a black-and-white image of the optical component 102 of an embodiment of the adjustable IOL 100 after a laser pulse (in this case, external energy) has been directed to the composite material 103 that constitutes part of the optical component 102.

[0228] like Figure 4A As shown, the optical component 102 may include a first annular segment 128 and a second annular segment 130. For example... Figure 4AAs shown, the diameter of the second annular segment 130 can be smaller than the diameter of the first annular segment 128. Furthermore, the second annular segment 130 can be positioned concentrically with the first annular segment 128.

[0229] Furthermore, the first annular segment 128 may be disconnected from or spaced apart from the second annular segment 130 (see also...) Figure 5 ).

[0230] like Figure 4A As shown, the laser pulse has been directed to numerous target locations 400 around the second annular segment 130 made of composite material 103. When viewed from a top-down perspective, the target locations 400 that have received the laser have expanded and appear as substantially circular points.

[0231] In this configuration, the volume of the optical component chamber 110 can be configured to decrease in response to the expansion of the composite material 103 at the target location 400. Consequently, the fluid pressure within the optical component chamber 110 can increase, causing the front element 106 to deform, flex, or otherwise change shape. This shape change can result in an increase in the fundamental power of the optical component portion 102.

[0232] Figure 4B This is a black-and-white image of the optical component 102 of another embodiment of the adjustable IOL 100 after a laser pulse (in this case, external energy) has been directed to the composite material 103 that constitutes part of the optical component 102. For example, Figure 4B The optical component 102 shown can be Figure 1 The optical component 102 and / or Figure 3 The assembled version of the optical components depicted.

[0233] The optical component 102 may include a first annular segment 128 and a second annular segment 130. For example... Figure 4B As shown, the diameter of the second annular segment 130 can be smaller than that of the first annular segment 128. Furthermore, the second annular segment 130 can be positioned concentrically with the first annular segment 128.

[0234] Furthermore, the first ring segment 128 may be connected to or otherwise coupled to the second ring segment 130. For example, the first ring segment 128 may be implemented as a large outer ring, and the second ring segment 130 may be implemented as a smaller inner ring that descends in a stepped manner to the large outer ring.

[0235] like Figure 4B As shown, the laser pulse has been directed to 35 target locations 400 surrounding the second annular segment 130. When viewed from a top-down perspective, the target locations 400 that have received the laser have expanded and appear as discrete, essentially circular points.

[0236] In this configuration, the volume of the optical component chamber 110 can be configured to decrease in response to the expansion of the composite material 103 at the target location 400. Consequently, the fluid pressure within the optical component chamber 110 can increase, causing the front element 106 to deform, flex, or otherwise change shape. This shape change can result in an increase in the fundamental power of the optical component portion 102.

[0237] Figure 4C It is a close-up black and white image showing the activated composite material 103 expanding into the optical chamber 110 in response to external energy being directed to the composite material 103. For example, the composite material 103 may be a second rear portion 114 disposed within the chamber base plate 122 of the optical portion 102.

[0238] When the composite material 103 is activated by receiving external energy (e.g., a laser pulse), at least a portion of the composite material 103 can rise from the chamber floor 122 and expand in the forward direction into the optical chamber 110. This expansion of the composite material 103 can reduce the volume of the optical chamber 110. Therefore, the base power of the optical portion 102 can be configured to increase in response to the external energy directed to the chamber floor 122.

[0239] Figure 4D The computed tomography (CT) scan shows that the activated composite material 103 forms part of the chamber wall 126 of the optical chamber 110 surrounding the optical component portion 102. For example, the composite material 103 may be a first rear portion 112 disposed within the chamber wall 126.

[0240] When the composite material 103 is activated by receiving external energy (e.g., a laser pulse), at least a portion of the composite material 103 can push outward (e.g., in a radially outward direction) against the chamber wall 126. This expansion of the composite material 103 can increase the volume of the optical chamber 110. Therefore, the base focal length of the optical portion 102 can be configured to decrease in response to external energy directed to the chamber wall 126.

[0241] Figure 5 A cross-sectional view of the optical component 102 of another embodiment of the adjustable IOL 100 is shown. (See attached image.) Figure 5 As shown, the rear element 108 may include a first rear portion 112 and a second rear portion 114. The first rear portion 112 and the second rear portion 114 may be made of composite material 103.

[0242] In some embodiments, the second rear portion 114 may be located radially inside the first rear portion 112. In these and other embodiments, the second rear portion 114 may also be located behind the first rear portion 112.

[0243] like Figure 5 As shown, the rear element 108 may include an outer rear surface 116, an inner rear surface 118 facing the optical chamber 110, and a raised periphery 120. At least a portion of the inner rear surface 118 may serve as a chamber floor 122 of the optical chamber 110. An inclined portion 124 of the inner rear surface 118 may serve as part of a chamber wall 126 surrounding the optical chamber 110.

[0244] In some embodiments, a first rear portion 112 may be disposed within a chamber wall 126, and a second rear portion 114 may be disposed within a chamber floor 122. In these and other embodiments, at least a portion of the chamber floor 122 of the optical component portion 102 may be made of composite material 103, and at least a portion of the chamber wall 126 of the optical component portion 102 may be made of composite material 103.

[0245] like Figure 4A and Figure 5 As shown, in some embodiments, the first rear portion 112 may be implemented in the form of a first annular segment 128 (see [reference]). Figure 4A ), and the second rear portion 114 can be implemented in the form of a second annular segment 130 (see Figure 4A The diameter of the second annular segment 130 can be smaller than the diameter of the first annular segment 128. The second annular segment 130 can be positioned concentrically with the first annular segment 128.

[0246] In these embodiments, the first annular segment 128 (first rear portion 112) may be disconnected from or spaced apart from the second annular segment 130 (second rear portion 114).

[0247] As will be discussed in more detail in the following sections, the base power of the optical component 102 may be configured to decrease in response to external energy (e.g., light energy) directed to the first rear portion 112. Additionally or alternatively, the base power of the optical component 102 may be configured to increase in response to external energy directed to the second rear portion 114.

[0248] The first rear portion 112 can be configured to expand in response to external energy directed to it. The expansion of the first rear portion 112 can increase the height of the optical chamber 110 by pushing upward against the interface 500 between the front element 106 and the rear element 108. In some embodiments, the interface 500 may be a glue gap or an adhesive layer. Therefore, the volume of the optical chamber 110 can increase in response to the expansion of the first rear portion 112.

[0249] Furthermore, the expansion of the first rear portion 112 can also push the chamber wall 126 outward, causing the optical component chamber 110 to expand radially. In this case, the volume of the optical component chamber 110 also increases.

[0250] exist Figure 5 In the illustrated embodiment, the first rear portion 112 (made of composite material 103) can be positioned in the glue gap or adhesive layer (in) Figure 5 This is shown as a later portion of interface 500, but is not part of the glue gap or adhesive layer. In this embodiment, the adhesive layer or interface 500 may be separate from the first rear portion 112.

[0251] The second rear portion 114 can be configured to expand in response to external energy directed to it. The volume of the optical chamber 110 can decrease in response to the expansion of the second rear portion 114. For example, at least a portion of the second rear portion 114 can be configured to expand in the forward direction (into the optical chamber 110) in response to external energy directed to it.

[0252] When the second rear portion 114 is disposed within the chamber floor 122, the base power of the optical portion 102 can be configured to increase in response to external energy directed to the chamber floor 122.

[0253] When the first rear portion 112 is disposed within a portion of the chamber wall 126, the base power of the optical portion 102 can be configured to decrease in response to external energy directed to the chamber wall 126.

[0254] Figure 6 This illustrates the action taken after the laser pulse is guided to the first rear portion 112 of the adjustable IOL 100. Figure 5 An image showing the results of a finite element analysis (FEA) performed on an embodiment of the adjustable IOL 100. Figure 6 As shown, laser pulses can be guided along the first rear portion 112, which forms part of the chamber wall 126, to multiple target locations.

[0255] At each target location, the composite material 103 constituting the first rear portion 112 can expand in a substantially spherical manner. This expansion can push the chamber wall 126 outward, causing the optical component chamber 110 to expand radially. In this case, the volume of the optical component chamber 110 increases. Therefore, the fluid pressure within the optical component chamber 110 decreases, and the fundamental focal length of the optical component portion 102 decreases.

[0256] Figure 7A cross-sectional view of the optical component 102 of another embodiment of the adjustable IOL 100 is shown, wherein the adhesive layer 700 comprises a composite material 103. The front element 106 can be bonded or adhered to the rear element 108 via the adhesive layer 700.

[0257] like Figure 7 As shown, the rear element 108 may include a rear portion 702 made of composite material 103. The rear portion 702 may be located radially inside the adhesive layer 700 at a radial position. The rear portion 702 may also be located behind the adhesive layer 700.

[0258] like Figure 7 As shown, the rear element 108 may include an outer rear surface 116, an inner rear surface 118 facing the optical chamber 110, and a raised periphery 120. At least a portion of the inner rear surface 118 may serve as a chamber floor 122 of the optical chamber 110. The raised periphery 120 may serve as part of a chamber wall 126 surrounding the optical chamber 110.

[0259] The adhesive layer 700 may be located at the interface or contact layer between the front element 106 and the rear element 108. For example, the adhesive layer 700 may be located between the raised periphery 120 of the rear element 108 and the radially outer periphery 704 of the front element 106. For example, the adhesive layer 700 may be implemented in the form of a first annular segment.

[0260] In some embodiments, the rear portion 702 may be disposed within the chamber floor 122. In these and other embodiments, at least a portion of the chamber floor 122 of the optical portion 102 may be made of composite material 103. For example, the rear portion 702 may be implemented as a second annular segment with a diameter smaller than that of the first annular segment. The second annular segment may be positioned concentrically with the first annular segment.

[0261] In some embodiments, the first annular segment may be disconnected from or spaced apart from the second annular segment.

[0262] The base focal length of the optical component 102 can be configured to decrease in response to external energy (e.g., light energy) directed to the adhesive layer 700. Additionally or alternatively, the base focal length of the optical component 102 can be configured to increase in response to external energy directed to the rear portion 702.

[0263] The adhesive layer 700 can be configured to expand in response to external energy directed to it. The rear portion 702 can be configured to expand in response to external energy directed to it. The expansion of the adhesive layer 700 can increase the height of the optical chamber 110 by pushing it upward against the front element 106 and downward against the rear element 108. The volume of the optical chamber 110 can increase in response to the expansion of the adhesive layer 700. Therefore, the base power of the optical portion 102 can be configured to decrease in response to external energy directed to the adhesive layer 700.

[0264] In some embodiments, the adhesive layer 700 may also be referred to as an adhesive gap or adhesive layer.

[0265] The rear portion 702 can be configured to expand in response to external energy directed to the rear portion 702. The volume of the optical component chamber 110 can decrease in response to the expansion of the rear portion 702. For example, at least a portion of the rear portion 702 can be configured to expand in the forward direction (into the optical component chamber 110) in response to external energy directed to the rear portion 702.

[0266] When the rear portion 702 is disposed within the chamber floor 122, the base focal length of the optical portion 102 can be configured to increase in response to external energy being directed to the chamber floor 122.

[0267] Figure 8 This demonstrates the effect after a laser pulse is directed to an adhesive layer 700 partially made of composite material 103. Figure 7 Images of the results of finite element analysis (FEA) performed by the adjustable IOL 100.

[0268] like Figure 8 As shown, laser pulses can be guided along the adhesive layer 700 to multiple target locations. At each target location, the composite material 103 constituting a portion of the adhesive layer 700 can expand in a substantially spherical manner. This expansion can push the rear element 108 further away from the front element 106, thereby increasing the volume of the optical component chamber 110. Consequently, the fluid pressure within the optical component chamber 110 decreases, and the fundamental focal power of the optical component portion 102 decreases.

[0269] Figure 9A A cross-sectional view of the optical component 102 of one embodiment of the adjustable IOL 100 is shown, wherein the composite material 103 extends radially inward from the chamber wall 126 of the adjustable IOL 100.

[0270] like Figure 9A and Figure 9BAs shown, the composite material 103 can be implemented as a circular edge 900 extending radially inward from the chamber wall 126 surrounding the optical chamber 110.

[0271] Figure 9B This demonstrates what happens after a laser pulse is guided to a composite material 103 (implemented as a rounded edge 900) extending radially inward from the chamber wall 126 of the adjustable IOL 100. Figure 9A A cross-sectional view of the optical component 102 of the adjustable IOL 100.

[0272] like Figure 9B As shown, a laser pulse can be guided along a circular edge 900 to multiple target locations 902. At each target location 902, the composite material 103 constituting a portion of the circular edge 900 can expand in a substantially spherical or circular manner. This expansion allows the portion of the circular edge 900 to extend radially inward into the optical component cavity 110. Therefore, the volume of the optical component cavity 110 can be reduced, and the fluid pressure within the optical component cavity 110 can be increased. This can cause an increase in the fundamental focal power of the optical component portion 102.

[0273] Figure 10A This is one embodiment of a method 1000 for adjusting an IOL post-surgery or post-implantation. Method 1000 may include, in operation 1002, directing external energy to a composite material portion of a rear element constituting the optical component of the IOL.

[0274] The optical component may further include a front element and an optical cavity defined between the front and rear elements. The optical cavity may be filled with fluid. The fundamental focal length of the optical component can be configured to vary in response to external energy directed to the composite material.

[0275] For example, operation 1002 may include directing external energy to a first rear portion within the chamber wall of the optics portion to reduce the fundamental power of the optics portion. Alternatively, for example, operation 1002 may include directing external energy to a second rear portion within the chamber floor to increase the fundamental power of the optics portion.

[0276] Method 1000 may also include measuring the change in fundamental focal length of the optical component after external energy is directed to the composite material in operation 1004.

[0277] Figure 10BThis is one embodiment of another method 1006 for adjusting an IOL post-surgery or post-implantation. Method 1000 may include directing external energy to a composite material portion of the adhesive layer constituting the optical component of the IOL in operation 1008. The adhesive layer may be configured to expand in response to the directing of external energy to the adhesive layer. The expansion of the adhesive layer may increase the volume of the optical cavity. The base power of the optical component may be configured to decrease in response to the directing of external energy to the composite material portion constituting the adhesive layer.

[0278] Method 1006 may also include, in operation 1010, an additional instance of a composite material in which external energy is directed to a portion of the rear element constituting the optical component of the IOL.

[0279] For example, operation 1010 may include directing external energy to a first rear portion within the chamber wall of the optics portion to further reduce the fundamental power of the optics portion. Alternatively, for example, operation 1010 may include directing external energy to a second rear portion within the chamber floor to increase the fundamental power of the optics portion.

[0280] Figure 10C This is one embodiment of another method 1012 for adjusting an IOL post-surgery or post-implantation. Method 1012 may include directing external energy to a portion of a circular edge of a composite material within an optical cavity that constitutes the optical portion of the IOL.

[0281] At least a portion of the circular edge can be configured to expand radially inward in response to external energy directed to the circular edge. This expansion of the circular edge can reduce the volume of the optical cavity and increase the fundamental focal power of the optical portion.

[0282] Method 1012 may further include measuring the change in the fundamental focal length of the optical component after external energy is directed to the composite material in operation 1016.

[0283] In one or more methods disclosed herein, directing external energy to the composite material may include directing a laser with a wavelength between about 488 nm and about 650 nm to the composite material. In other embodiments, directing external energy to the composite material may further include directing a laser with a wavelength between about 946 nm and about 1120 nm to the composite material.

[0284] One drawback of currently available tunable IOLs (such as optically adjustable lenses) is that the tuning process takes time to take effect, may require multiple visits to a clinician's office, and clinicians must frequently purchase expensive new equipment to perform such tuning procedures.

[0285] One advantage of the adjustable IOL 100 disclosed in this article is that it allows for postoperative refractive error correction in seconds rather than hours. This allows patients to provide feedback on their refractive error correction almost instantly. Furthermore, the IOL 100 disclosed in this article can be tuned using commercially available lasers (e.g., 532 nm photocoagulation lasers) commonly found in most clinicians' offices.

[0286] This disclosure also covers the following provisions, which may be incorporated, in whole or in part, into the embodiments:

[0287] Clause 1. An adjustable intraocular lens comprising: an optical portion including: a front element, a rear element, and an optical chamber defined therebetween, wherein the optical chamber is filled with fluid, wherein at least a portion of the rear element is made of a composite material, and wherein the base power of the optical portion is configured to vary in response to external energy directed to the composite material.

[0288] Clause 2. An adjustable intraocular lens as described in Clause 1, wherein the rear element comprises a first rear portion and a second rear portion, and wherein the first rear portion and the second rear portion are made of the composite material.

[0289] Clause 3. An adjustable intraocular lens as described in Clause 2, wherein the second rear portion is located radially inside the first rear portion.

[0290] Clause 4. An adjustable intraocular lens as described in Clause 2 or Clause 3, wherein the second rear portion is located behind the first rear portion.

[0291] Clause 5. An adjustable intraocular lens as described in any one of Clauses 2 to 4, wherein the fundamental focal power of the optical element portion is configured to decrease in response to the external energy directed to the first rear portion.

[0292] Clause 6. An adjustable intraocular lens as described in any one of Clauses 2 to 5, wherein the first rear portion is configured to expand in response to external energy directed to the first rear portion, and wherein the expansion of the first rear portion increases the volume of the optical chamber.

[0293] Clause 7. An adjustable intraocular lens as described in any one of Clauses 2 to 6, wherein the base power of the optical element portion is configured to increase in response to the external energy directed to the second rear portion.

[0294] Clause 8. An adjustable intraocular lens as described in any one of Clauses 2 to 7, wherein the second rear portion is configured to expand in response to external energy directed to the second rear portion, and wherein the expansion of the second rear portion reduces the volume of the optical chamber.

[0295] Clause 9. An adjustable intraocular lens as described in any one of Clauses 2 to 8, wherein the first rear portion is in the form of a first annular segment, and wherein the second rear portion is in the form of a second annular segment.

[0296] Clause 10. An adjustable intraocular lens as described in Clause 9, wherein the diameter of the second annular segment is smaller than the diameter of the first annular segment.

[0297] Clause 11. An adjustable intraocular lens as described in Clause 9, wherein the second annular segment is positioned concentric with the first annular segment and radially inside the first annular segment.

[0298] Clause 12. An adjustable intraocular lens as described in any one of Clauses 2 to 11, wherein the rear element includes an outer rear surface and an inner rear surface facing the optical chamber, and wherein a portion of the inner rear surface serves as the chamber floor of the optical chamber.

[0299] Clause 13. An adjustable intraocular lens as described in Clause 12, wherein the second rear portion is disposed within the chamber floor.

[0300] Clause 14. An adjustable intraocular lens as described in Clause 12 or Clause 13, wherein a portion of the second rear portion is configured to expand in a forward direction in response to external energy directed to the second rear portion.

[0301] Clause 15. An adjustable intraocular lens as described in any one of Clauses 12 to 14, wherein the inclined portion of the inner posterior surface serves as part of the chamber wall of the optical element chamber.

[0302] Clause 16. An adjustable intraocular lens as described in Clause 15, wherein the first rear portion is disposed within an inclined portion of the inner rear surface.

[0303] Clause 17. An adjustable intraocular lens as described in any one of Clauses 12 to 16, wherein a portion of the first rear portion is configured to expand in a radially outward direction in response to external energy directed to the first rear portion.

[0304] Clause 18. An adjustable intraocular lens as described in any one of Clauses 2 to 17, wherein the rear element further includes a raised periphery.

[0305] Clause 19. An adjustable intraocular lens as described in Clause 18, wherein the first rear portion is disposed within the protruding periphery of the rear element.

[0306] Clause 20. An adjustable intraocular lens as described in Clause 18 or Clause 19, wherein a portion of the first rear portion is configured to expand in response to external energy directed to the first rear portion, and wherein the expansion of the first rear portion increases the volume of the optical chamber.

[0307] Clause 21. An adjustable intraocular lens as described in any one of Clauses 1 to 20, wherein the anterior element is bonded or adhered to the rear element by an adhesive layer, wherein the adhesive layer further comprises the composite material.

[0308] Clause 22. An adjustable intraocular lens as described in Clause 21, wherein the adhesive layer is configured to expand in response to external energy directed to the adhesive layer, and wherein the expansion of the adhesive layer increases the volume of the optical chamber.

[0309] Clause 23. An adjustable intraocular lens as described in Clause 21 or Clause 22, wherein the base power of the optical element is configured to decrease in response to the external energy directed to the adhesive layer.

[0310] Clause 24. An adjustable intraocular lens as described in Clause 22 or Clause 23, wherein the composite material within the rear element is configured to expand in response to external energy directed to the composite material within the rear element, wherein the expansion of the composite material within the rear element reduces the volume of the optical chamber.

[0311] Clause 25. An adjustable intraocular lens as described in any one of Clauses 21 to 24, wherein the base power of the optical element is configured to increase in response to the external energy directed to the composite material within the rear element.

[0312] Clause 26. An adjustable intraocular lens as described in any one of Clauses 1 to 25, wherein a portion of the rear element serves as a chamber wall surrounding the optical chamber, wherein the rear element further includes a circular edge extending radially inward from the chamber wall, wherein the circular edge is made of the composite material.

[0313] Clause 27. An adjustable intraocular lens as described in Clause 26, wherein at least a portion of the circular edge is configured to expand in a radially inward direction in response to external energy directed to the circular edge.

[0314] Clause 28. An adjustable intraocular lens as described in Clause 26 or Clause 27, wherein the expansion of the circular edge reduces the volume of the optical chamber and increases the fundamental power of the optical portion.

[0315] Clause 29. An adjustable intraocular lens as described in any one of Clauses 1 to 28, wherein the composite material comprises an energy-absorbing component and a plurality of expandable components.

[0316] Clause 30. An adjustable intraocular lens as described in Clause 29, wherein the expandable component is an expandable microsphere.

[0317] Clause 31. An adjustable intraocular lens as described in Clause 29 or Clause 30, wherein the energy-absorbing component is an energy-absorbing colorant.

[0318] Clause 32. An adjustable intraocular lens as described in any one of Clauses 1 to 31, wherein the external energy is a laser with a wavelength between about 488 nm and about 650 nm.

[0319] Clause 33. An adjustable intraocular lens as described in any one of Clauses 1 to 31, wherein the external energy is a laser with a wavelength between about 946 nm and about 1120 nm.

[0320] Clause 34. An adjustable intraocular lens as described in any one of Clauses 1 to 33, wherein the base focal power of the optical element is configured to vary by a total of about 0.05 D to about 3.0 D in response to a pulse of external energy directed to the composite material.

[0321] Clause 35. An adjustable intraocular lens as described in any one of Clauses 1 to 34, wherein the anterior element includes an external optical surface, and wherein the external optical surface includes a diffractive surface profile or pattern defined on the external optical surface.

[0322] Clause 36. The adjustable intraocular lens as described in any one of Clauses 1 to 35 further includes one or more loops extending from the optical element portion.

[0323] Clause 37. A method for adjusting an intraocular lens after implantation, the method comprising: directing external energy to a composite material of a portion of a rear element constituting an optical element portion of the intraocular lens, wherein the optical element portion further includes: an anterior element, and an optical element chamber defined between the anterior element and the rear element, wherein the optical element chamber is filled with fluid, and wherein the fundamental power of the optical element portion is configured to vary in response to the external energy being directed to the composite material; and measuring the change in the fundamental power of the optical element portion after the external energy is directed to the composite material.

[0324] Clause 38. The method as described in Clause 37, wherein the rear element comprises a first rear portion and a second rear portion, and wherein the first rear portion and the second rear portion are made of the composite material.

[0325] Clause 39. The method as described in Clause 38, wherein the second rear portion is located radially inside the first rear portion.

[0326] Clause 40. The method as described in Clause 38 or Clause 39, wherein the second rear portion is located behind the first rear portion.

[0327] Clause 41. The method of any one of Clauses 38 to 40 further comprises: directing the external energy to the first rear portion in order to reduce the fundamental focal power of the optical portion.

[0328] Clause 42. The method of any one of Clauses 38 to 41, wherein the first rear portion is configured to expand in response to external energy directed to the first rear portion, and wherein the expansion of the first rear portion increases the volume of the optical chamber.

[0329] Clause 43. The method of any one of Clauses 38 to 42 further comprises: directing the external energy to the second rear portion in order to increase the fundamental focal power of the optical portion.

[0330] Clause 44. The method of any one of Clauses 38 to 43, wherein the second rear portion is configured to expand in response to external energy directed to the second rear portion, and wherein the expansion of the second rear portion reduces the volume of the optical chamber.

[0331] Clause 45. The method of any one of Clauses 38 to 44, wherein the first rear portion is in the form of a first annular segment, and wherein the second rear portion is in the form of a second annular segment.

[0332] Clause 46. The method as described in Clause 45, wherein the diameter of the second annular segment is smaller than the diameter of the first annular segment.

[0333] Clause 47. The method as described in Clause 45, wherein the second annular segment is positioned concentric with the first annular segment and radially inside the first annular segment.

[0334] Clause 48. The method of any one of Clauses 38 to 47, wherein the rear element includes an outer rear surface and an inner rear surface facing the optical chamber, and wherein a portion of the inner rear surface serves as the chamber floor of the optical chamber.

[0335] Clause 49. The method as described in Clause 48, wherein the second rear portion is disposed within the chamber floor.

[0336] Clause 50. The method as described in Clause 48 or Clause 49 further includes directing the external energy to the second rear portion within the chamber floor, wherein a portion of the second rear portion is configured to expand in a forward direction in response to the external energy being directed to the second rear portion within the chamber floor.

[0337] Clause 51. The method of any one of Clauses 48 to 50, wherein the inclined portion of the inner rear surface serves as part of the chamber wall of the optical element chamber.

[0338] Clause 52. The method as described in Clause 51, wherein the first rear portion is disposed within the inclined portion of the inner rear surface.

[0339] Clause 53. The method of any one of Clauses 48 to 52 further comprises: directing the external energy to the first rear portion, wherein a portion of the first rear portion is configured to expand in a radially outward direction in response to the external energy being directed to the first rear portion.

[0340] Clause 54. The method as described in any one of Clauses 38 to 53, wherein the rear element further includes a raised periphery.

[0341] Clause 55. The method as described in Clause 54, wherein the first rear portion is disposed within the protruding periphery of the rear element.

[0342] Clause 56. The method as described in Clause 54 or Clause 55 further includes directing the external energy to the first rear portion, wherein a portion of the first rear portion is configured to expand in response to the external energy being directed to the first rear portion, and wherein the expansion of the first rear portion increases the volume of the optical chamber.

[0343] Clause 57. The method of any one of Clauses 37 to 56, wherein the front element is bonded or adhered to the rear element by an adhesive layer, wherein the adhesive layer further comprises the composite material.

[0344] Clause 58. The method of Clause 57 further includes directing the external energy to the adhesive layer, wherein the adhesive layer is configured to expand in response to the external energy being directed to the adhesive layer, and wherein the expansion of the adhesive layer increases the volume of the optical cavity.

[0345] Clause 59. The method as described in Clause 57 or Clause 58, wherein the base focal length of the optical component is configured to decrease in response to the external energy directed to the adhesive layer.

[0346] Clause 60. The method as described in Clause 58 or Clause 59 further includes directing the external energy to a composite material within the rear element, wherein the composite material within the rear element is configured to expand in response to the external energy being directed to the rear element, wherein the expansion of the composite material within the rear element reduces the volume of the optical cavity.

[0347] Clause 61. The method of any one of Clauses 57 to 60, wherein the base focal length of the optical component is configured to increase in response to the external energy directed to the composite material within the rear element.

[0348] Clause 62. The method of any one of Clauses 37 to 61, wherein a portion of the rear element serves as a chamber wall surrounding the optical chamber, wherein the rear element further includes a circular edge extending radially inward from the chamber wall, wherein the circular edge is made of the composite material.

[0349] Clause 63. The method of Clause 62 further includes directing the external energy to the circular edge, wherein at least a portion of the circular edge is configured to expand in a radially inward direction in response to the external energy being directed to the circular edge, and wherein the expansion of the circular edge reduces the volume of the optical cavity and increases the fundamental focal power of the optical portion.

[0350] Clause 64. The method of any one of Clauses 37 to 63, wherein the composite material comprises an energy-absorbing component and a plurality of expandable components.

[0351] Clause 65. The method as described in Clause 64, wherein the expandable component is expandable microspheres.

[0352] Clause 66. The method as described in Clause 64 or Clause 65, wherein the energy-absorbing component is an energy-absorbing colorant.

[0353] Clause 67. The method as described in any one of Clauses 37 to 66, wherein the external energy is a laser with a wavelength between about 488 nm and about 650 nm.

[0354] Clause 68. The method of any one of Clauses 37 to 66, wherein the external energy is a laser with a wavelength between about 946 nm and about 1120 nm.

[0355] Clause 69. The method of any one of Clauses 37 to 68, wherein the base focal length of the optical component is configured to vary by a total of about 0.05 D to about 3.0 D in response to a pulse of external energy directed to the composite material.

[0356] Clause 70. The method of any one of Clauses 37 to 69, wherein the front element includes an external optical surface, wherein the external optical surface includes a diffractive surface profile or pattern defined on the external optical surface.

[0357] Clause 71. The method of any one of Clauses 37 to 70, wherein the intraocular lens further includes one or more loops extending from the optical element portion.

[0358] Clause 72. An adjustable intraocular lens comprising: an optical element portion including an optical element chamber filled with fluid, wherein the optical element chamber includes: a chamber floor and a chamber wall, wherein at least a portion of the chamber floor is made of a composite material, and wherein the fundamental power of the optical element portion is configured to vary in response to external energy directed to the chamber floor.

[0359] Clause 73. An adjustable intraocular lens as described in Clause 72, wherein the fundamental power of the optical element is configured to increase in response to the external energy directed to the chamber floor.

[0360] Clause 74. An adjustable intraocular lens as described in Clause 72 or Clause 73, wherein at least a portion of the chamber wall is made of the composite material, and wherein the base power of the optical portion is configured to vary in response to external energy directed to these chamber walls.

[0361] Clause 75. An adjustable intraocular lens as described in Clause 74, wherein the fundamental focal power of the optical element is configured to decrease in response to the external energy directed to the walls of these chambers.

[0362] Clause 76. An adjustable intraocular lens comprising: an optical element portion including: an optical element chamber filled with fluid, wherein at least a portion of the optical element chamber is made of a composite material, and wherein the base power of the optical element portion is configured to vary in response to external energy directed to the composite material.

[0363] Clause 77. An adjustable intraocular lens as described in Clause 76, wherein the optical element portion includes a first optical element portion and a second optical element portion, and wherein the first optical element portion and the second optical element portion are made of the composite material.

[0364] Clause 78. An adjustable intraocular lens as described in Clause 77, wherein the second optical element portion is located radially inside the first optical element portion.

[0365] Clause 79. An adjustable intraocular lens as described in Clause 77 or Clause 78, wherein the second optical element portion is located behind the first optical element portion.

[0366] Clause 80. An adjustable intraocular lens as described in any one of Clauses 77 to 79, wherein the fundamental focal power of the optical element portion is configured to decrease in response to the external energy directed to the first optical element portion.

[0367] Clause 81. An adjustable intraocular lens as described in any one of Clauses 77 to 80, wherein the first optical portion is configured to expand in response to external energy directed to the first optical portion, and wherein the expansion of the first optical portion increases the volume of the optical chamber.

[0368] Clause 82. An adjustable intraocular lens as described in any one of Clauses 77 to 81, wherein the base power of the optical element portion is configured to increase in response to the external energy directed to the second optical element portion.

[0369] Clause 83. An adjustable intraocular lens as described in any one of Clauses 77 to 82, wherein the second optical portion is configured to expand in response to external energy directed to the second optical portion, and wherein the expansion of the second optical portion reduces the volume of the optical chamber.

[0370] Clause 84. An adjustable intraocular lens as described in any one of Clauses 77 to 83, wherein the first optical element portion is in the form of a first annular segment, and wherein the second optical element portion is in the form of a second annular segment.

[0371] Clause 85. An adjustable intraocular lens as described in Clause 84, wherein the diameter of the second annular segment is smaller than the diameter of the first annular segment.

[0372] Clause 86. An adjustable intraocular lens as described in Clause 84, wherein the second annular segment is positioned concentric with the first annular segment and radially inside the first annular segment.

[0373] Clause 87. An adjustable intraocular lens as described in any one of Clauses 77 to 86, wherein the optical element comprises a chamber floor and a chamber wall.

[0374] Clause 88. An adjustable intraocular lens as described in Clause 87, wherein the second optic is partially disposed within the chamber floor.

[0375] Clause 89. An adjustable intraocular lens as described in Clause 87 or Clause 88, wherein a portion of the second optical element is configured to expand in a forward direction in response to external energy directed to the second optical element.

[0376] Clause 90. An adjustable intraocular lens as described in any one of Clauses 87 to 89, wherein at least a portion of the chamber wall is inclined.

[0377] Clause 91. An adjustable intraocular lens as described in Clause 90, wherein the first optical element is disposed within an inclined portion of the chamber wall.

[0378] Clause 92. An adjustable intraocular lens as described in any one of Clauses 87 to 91, wherein a portion of the first optical element is configured to expand in a radially outward direction in response to external energy directed to the first optical element.

[0379] Clause 93. An adjustable intraocular lens as described in Clause 92, wherein expansion of the first optical element portion increases the volume of the optical element chamber.

[0380] Clause 94. An adjustable intraocular lens as described in any one of Clauses 76 to 93, wherein the optical component includes an adhesive layer, wherein the adhesive layer includes the composite material.

[0381] Clause 95. An adjustable intraocular lens as described in Clause 94, wherein the adhesive layer is configured to expand in response to external energy directed to the adhesive layer, and wherein the expansion of the adhesive layer increases the volume of the optical chamber.

[0382] Clause 96. An adjustable intraocular lens as described in Clause 94 or Clause 95, wherein the fundamental focal power of the optical element portion is configured to decrease in response to the external energy directed to the adhesive layer.

[0383] Clause 97. An adjustable intraocular lens as described in any one of Clauses 76 to 96, wherein the optical element portion includes a chamber wall surrounding the optical element chamber, wherein the optical element portion includes a circular edge extending radially inward from the chamber wall, wherein the circular edge is made of the composite material.

[0384] Clause 98. An adjustable intraocular lens as described in Clause 97, wherein at least a portion of the circular edge is configured to expand in a radially inward direction in response to external energy directed to the circular edge.

[0385] Clause 99. An adjustable intraocular lens as described in Clause 98, wherein the expansion of the circular edge reduces the volume of the optical chamber and increases the fundamental power of the optical portion.

[0386] Clause 100. An adjustable intraocular lens as described in any one of Clauses 76 to 99, wherein the composite material comprises an energy-absorbing component and a plurality of expandable components.

[0387] Clause 101. An adjustable intraocular lens as described in Clause 100, wherein the expandable component is an expandable microsphere.

[0388] Clause 102. An adjustable intraocular lens as described in Clause 100 or Clause 101, wherein the energy-absorbing component is an energy-absorbing colorant.

[0389] Clause 103. An adjustable intraocular lens as described in any one of Clauses 76 to 102, wherein the external energy is a laser with a wavelength between about 488 nm and about 650 nm.

[0390] Clause 104. An adjustable intraocular lens as described in any one of Clauses 76 to 102, wherein the external energy is a laser with a wavelength between about 946 nm and about 1120 nm.

[0391] Clause 105. An adjustable intraocular lens as described in any one of Clauses 76 to 104, wherein the base power of the optical element is configured to vary by a total of about 0.05D to about 3.0D in response to a pulse of external energy directed to the composite material.

[0392] Clause 106. An adjustable intraocular lens as described in any one of Clauses 76 to 105, wherein the optical element portion includes an external optical surface, and wherein the external optical surface includes a diffractive surface profile or pattern defined on the external optical surface.

[0393] Clause 107. The adjustable intraocular lens as described in any one of Clauses 76 to 106 further includes one or more loops extending from the optical element portion.

[0394] Several embodiments have been described. However, those skilled in the art will understand that various changes and modifications can be made to this disclosure without departing from the spirit and scope of the embodiments. Elements of the systems, apparatuses, devices, and methods shown with any embodiments are exemplary for particular embodiments and can be used in combination or otherwise in other embodiments within this disclosure. For example, steps of any method depicted in the figures or described in this disclosure do not require the specific order or sequence shown or described to achieve the desired result. Alternatively, other steps may be provided, or steps or operations may be eliminated or omitted from the described methods or processes to achieve the desired result. Furthermore, any component or portion of any device or system described in this disclosure or depicted in the figures may be removed, eliminated, or omitted to achieve the desired result. Additionally, for brevity and clarity, certain components or portions of the systems, apparatuses, or devices shown or described herein have been omitted.

[0395] Accordingly, other embodiments are within the scope of the following claims, and the description and / or drawings may be considered illustrative rather than restrictive.

[0396] Each of the individual variations or embodiments described and illustrated herein has discrete components and features that can be readily separated from or combined with features of any of the other variations or embodiments. Modifications may be made to adapt particular circumstances, materials, composition, processes, process actions, or steps to the objectives, spirit, or scope of the invention.

[0397] The methods described herein can be performed in any logically possible order of the events described, as well as in the order of the events themselves. Furthermore, additional steps or operations may be provided, or steps or operations may be eliminated to achieve the desired result.

[0398] Furthermore, where a range of values ​​is provided, every intermediate value between the upper and lower limits of that range, as well as any other statement or intermediate value within that range, is covered within the scope of this invention. Moreover, any optional features of the described inventive variations may be set forth and claimed independently or in combination with any one or more features described herein. For example, the description of ranges 1 to 5 should be considered as having disclosed subranges (e.g., 1 to 3, 1 to 4, 2 to 4, 2 to 5, 3 to 5, etc.) as well as individual numbers within that range (e.g., 1.5, 2.5, etc.) and any overall or partial increments therebetween.

[0399] All existing subjects mentioned herein (e.g., publications, patents, patent applications) are incorporated herein by reference in their entirety, except where such subject matter might conflict with the subject matter of this invention (in which case the content herein shall prevail). Items cited are provided only because they were disclosed prior to the filing date of this application. Nothing herein should be construed as an admission that this invention is not entitled to precedence over such material by virtue of a prior invention.

[0400] References to singular items include the possibility that multiple identical items exist. More specifically, as used herein and in the appended claims, the singular forms “a / an,” “the,” and “the” include the plural referents unless the context clearly indicates otherwise. It should be further noted that claims may be drafted to exclude any optional elements. Thus, this statement is intended to serve as a prior basis for the use of exclusive terms such as “only,” “merely,” etc., when referencing claim elements or using the “negative” limitation. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0401] The phrase “at least one of…” refers to any combination of one or more of those items or components when such a phrase modifies multiple items or components (or an enumerated list of items or components). For example, the phrase “at least one of A, B, and C” means: (i) A; (ii) B; (iii) C; (iv) A, B, and C; (v) A and B; (vi) B and C; or (vii) A and C.

[0402] In understanding the scope of this disclosure, the term "comprising" and its derivatives, as used herein, are intended to be open-ended terms that specify the presence of stated features, elements, components, groups, integers, and / or steps, but do not exclude the presence of other unstated features, elements, components, groups, integers, and / or steps. The foregoing also applies to words with similar meanings, such as the terms "comprising," "having," and their derivatives. Furthermore, the terms "section," "section," "part," "component," "element," or "part" when used in the singular can have a dual meaning of a single part or multiple parts. As used herein, the following directional terms "forward, backward, above, downward, vertical, horizontal, below, lateral, sideways, and vertical," and any other similar directional terms, refer to those positions of the device or equipment or those directions in which the device or equipment is translated or moved.

[0403] Finally, degree terms as used herein (such as “basically,” “about,” and “approximately”) refer to a specified value or a specified value plus a reasonable amount of deviation from the specified value (e.g., a deviation of up to ±0.1%, ±1%, ±5%, or ±10%, as such variation is appropriate) such that the final result is not significantly or substantially altered. For example, “about 1.0 cm” could be interpreted as meaning “1.0 cm” or between “0.9 cm and 1.1 cm.” When degree terms (such as “about” or “approximately”) are used to refer to numbers or values ​​that are part of a range, the term can be used to modify both the minimum and maximum numbers or values.

[0404] This disclosure is not intended to be limited to the specific forms set forth herein, but rather to cover alternatives, modifications, and equivalents to the variations or embodiments described herein. Furthermore, the scope of this disclosure fully encompasses other variations or embodiments that may become apparent to those skilled in the art in light of this disclosure.

Claims

1. An adjustable intraocular lens, comprising: The optical component includes: Front components, Rear components, and An optical component chamber defining the space between the front element and the rear element. The optical component cavity is filled with fluid. Wherein, at least a portion of the rear component is made of a composite material, and The base focal length of the optical component is configured to change in response to external energy directed to the composite material.

2. The adjustable intraocular lens as described in claim 1, wherein, The rear element includes a first rear portion and a second rear portion, wherein the first rear portion and the second rear portion are made of the composite material.

3. The adjustable intraocular lens as described in claim 2, wherein, The second rear portion is located radially inside the first rear portion.

4. The adjustable intraocular lens as described in claim 2, wherein, The second rear portion is located behind the first rear portion.

5. The adjustable intraocular lens as described in claim 2, wherein, The base focal length of the optical component is configured to decrease in response to the external energy being directed to the first rear portion.

6. The adjustable intraocular lens as described in claim 5, wherein, The first rear portion is configured to expand in response to external energy directed to the first rear portion, and wherein the expansion of the first rear portion increases the volume of the optical chamber.

7. The adjustable intraocular lens as described in claim 2, wherein, The base focal length of the optical component is configured to increase in response to the external energy being directed to the second rear portion.

8. The adjustable intraocular lens as described in claim 7, wherein, The second rear portion is configured to expand in response to external energy directed to the second rear portion, and wherein the expansion of the second rear portion reduces the volume of the optical chamber.

9. The adjustable intraocular lens as described in claim 2, wherein, The first rear portion is in the form of a first annular segment, and the second rear portion is in the form of a second annular segment.

10. The adjustable intraocular lens as described in claim 9, wherein, The diameter of the second annular segment is smaller than the diameter of the first annular segment.

11. The adjustable intraocular lens as described in claim 9, wherein, The second annular segment is positioned concentric with the first annular segment and radially inside the first annular segment.

12. The adjustable intraocular lens as described in claim 2, wherein, The rear element includes an outer rear surface and an inner rear surface facing the optical chamber, wherein a portion of the inner rear surface serves as the chamber floor of the optical chamber.

13. The adjustable intraocular lens as described in claim 12, wherein, The second rear portion is disposed within the bottom plate of the chamber.

14. The adjustable intraocular lens as described in claim 13, wherein, A portion of the second rear portion is configured to expand in the forward direction in response to external energy directed to the second rear portion.

15. The adjustable intraocular lens as described in claim 12, wherein, The inclined portion of the inner rear surface serves as part of the chamber wall of the optical component chamber.

16. The adjustable intraocular lens as described in claim 15, wherein, The first rear portion is disposed within the inclined portion of the inner rear surface.

17. The adjustable intraocular lens as described in claim 16, wherein, A portion of the first rear portion is configured to expand in a radially outward direction in response to external energy directed to the first rear portion.

18. A method for adjusting an intraocular lens after implantation, the method comprising: External energy is directed to a portion of the composite material of the rear element of the optical component of the intraocular lens, wherein the optical component further comprises: Front components, and An optical component chamber, defined between the front element and the rear element. The optical component cavity is filled with fluid, and The base focal length of the optical component is configured to vary in response to external energy directed to the composite material; and The change in the fundamental focal length of the optical component was measured after the external energy was directed to the composite material.

19. An adjustable intraocular lens, comprising: The optical component portion includes an optical component chamber filled with fluid, wherein the optical component chamber includes: The chamber floor, and chamber wall, Wherein, at least a portion of the chamber floor plate is made of a composite material, and The base focal length of the optical component is configured to vary in response to external energy directed to the chamber floor.

20. An adjustable intraocular lens, comprising: The optical component includes: Optical chambers filled with fluid. Wherein, at least a portion of the optical component cavity is made of a composite material, and The base focal length of the optical component is configured to change in response to external energy directed to the composite material.

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