Sample conveying method, sample conveying device and computer readable storage medium

Abstract

The invention discloses a sample conveying method, a sample conveying device and a computer readable storage medium. The sample conveying method comprises the following steps: conveying an isolation medium to a conveying pipeline filled with carrier liquid; introducing the sample medium into a conveying pipeline to form a sequence of the isolation medium, the sample medium and the isolation medium from upstream to downstream; pushing the medium in the conveying pipeline to enable the sample medium to reach a preset position; the medium in the conveying pipeline is pushed to a preset volume, so that the sample medium is located at the detection position of the detection area. Therefore, by means of the sample conveying method, the moment when the sample medium reaches the preset position can be captured, the event serves as a positioning datum point, the datum point serves as a starting point, and the sample medium can be accurately conveyed to the detection position only by executing pushing of a short distance and a fixed preset volume. And therefore, a long-distance conveying problem which is susceptible to interference is converted into a short-distance conveying problem, and the conveying precision is improved.

Description

Sample delivery method, sample delivery device, and computer-readable storage medium Technical Field

[0001] This application relates to the field of sample delivery, and in particular to a sample delivery method, a sample delivery device, and a computer-readable storage medium. Background Technology

[0002] In related technologies, with the increasing demand for high-throughput screening, reaction mechanism research, and condition optimization in chemical research, the direct integration of automated flow synthesis platforms with online analytical instruments (such as nuclear magnetic resonance spectrometers and mass spectrometers) has become a key technological trend. One of the bottlenecks in this technology lies in how to accurately deliver the trace samples generated in the reactor to the detection area of ​​the analytical instrument through pipelines.

[0003] Currently, open-loop control logic is used to deliver samples, which means that the sample is "blindly pushed" to the detection area based on the pre-calibrated total volume of the pipeline and the theoretical flow rate of the pump. Since the pump flow rate will fluctuate slightly due to changes in back pressure, the pipeline will undergo elastic deformation due to pressure, and the fluid viscosity will change due to temperature changes, these cumulative errors will cause the final stopping position of the sample to deviate from the target point, and the degree of deviation may be different in each experiment, which seriously affects the reliability of the analysis results. Summary of the Invention

[0004] This application aims to at least solve one of the technical problems existing in the prior art. To this end, one objective of this application is to propose a sample transport method that transforms a disturbance-prone long-distance transport problem into a short-distance transport problem, thereby improving the transport accuracy.

[0005] The sample delivery method according to this application includes: delivering an isolation medium into a delivery pipeline filled with a carrier liquid; introducing a sample medium into the delivery pipeline to form a sequential sequence from upstream to downstream of the isolation medium, the sample medium, and the isolation medium; pushing the medium in the delivery pipeline to bring the sample medium to a preset position; and pushing the medium in the delivery pipeline by a preset volume to place the sample medium at a detection position in the detection zone.

[0006] According to the sample delivery method of this application, the instant when the sample medium arrives at the preset position can be captured and this event can be used as the positioning reference point. Starting from the reference point, only a short distance and a fixed preset volume push need to be performed to accurately deliver the sample medium to the detection position, thereby transforming a long-distance delivery problem that is susceptible to interference into a short-distance delivery problem and improving the delivery accuracy.

[0007] In some examples of this application, the delivery of the isolation medium into the delivery pipeline filled with the carrier liquid includes: delivering a fixed amount of the isolation medium into the delivery pipeline filled with the carrier liquid.

[0008] In some examples of this application, the delivery of a quantitative amount of the isolation medium includes: delivering the isolation medium until the delivery stops when the isolation medium triggers a first sensor.

[0009] In some examples of this application, the delivery of the isolation medium to the delivery pipeline filled with the carrier liquid further includes: positioning a portion of the isolation medium within the first channel of a switching valve; the introduction of the sample medium into the delivery pipeline to form a sequential sequence from upstream to downstream of the isolation medium, the sample medium, and the isolation medium includes: introducing the sample medium into the second channel of the switching valve, and switching the switching valve to interchange the second channel with the first channel to form a sequential sequence from upstream to downstream of the isolation medium, the sample medium, and the isolation medium.

[0010] In some examples of this application, the second sensor triggers a first signal when it detects the isolation medium, and triggers a second signal when it detects both the sample medium and the carrier liquid; the sample delivery method further includes: when the second sensor detects a second transition from the first signal to the second signal, it determines that the sample medium has reached the preset position.

[0011] In some examples of this application, the isolation medium is constructed as a liquid or a gas.

[0012] In some examples of this application, the detection signal of the second sensor is obtained using binary digital signals and processed using run-length encoding.

[0013] In some examples of this application, after processing with run-length encoding, the first signal segment with a duration less than a preset threshold is merged and corrected. If a second signal segment precedes the first signal segment with a duration less than the preset threshold, it is merged into the preceding second signal segment. If a second signal segment does not precede the first signal segment with a duration less than the preset threshold, it is determined to be the first signal segment.

[0014] This application further proposes a computer-readable storage medium.

[0015] According to the computer-readable storage medium of this application, a control program for a sample delivery method is stored thereon, which, when executed by a processor, implements the sample delivery method described above.

[0016] According to the computer-readable storage medium of this application, the instant when the sample medium arrives at the preset position can be captured and this event can be used as the positioning reference point. Starting from the reference point, only a short-distance, fixed-volume push is needed to accurately deliver the sample medium to the detection position, thereby transforming a long-distance transport problem susceptible to interference into a short-distance transport problem and improving the transport accuracy.

[0017] This application further proposes a sample delivery device.

[0018] The sample delivery device according to this application includes a memory, a processor, and a control program for a sample delivery method stored in the memory and executable on the processor. When the processor executes the control program for the sample delivery method, it implements the sample delivery method described above.

[0019] According to the sample delivery device of this application, the instant when the sample medium arrives at the preset position can be captured and this event can be used as the positioning reference point. Starting from the reference point, only a short distance and a fixed preset volume push need to be performed to accurately deliver the sample medium to the detection position, thereby transforming a long-distance delivery problem that is susceptible to interference into a short-distance delivery problem and improving the delivery accuracy.

[0020] Additional aspects and advantages of this application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of this application. Attached Figure Description

[0021] The above and / or additional aspects and advantages of this application will become apparent and readily understood from the description of the embodiments in conjunction with the following drawings, in which: FIG1 is a flowchart of a sample delivery method according to an embodiment of this application; FIG2 is a schematic diagram of a switching valve before switching according to an embodiment of this application (the second channel is not connected to the delivery pipeline); FIG3 is a schematic diagram of a switching valve after switching according to an embodiment of this application (the second channel is connected to the delivery pipeline); FIG4 is a block diagram of a processor, memory, communication interface, and communication bus according to an embodiment of this application.

[0022] Reference numerals: delivery pipeline 10; first sub-pipeline 11; second sub-pipeline 12; switching valve 20; first channel 21; second channel 22; processor 1201; communication interface 1202; memory 1203; communication bus 1204. Detailed Implementation

[0023] The embodiments of this application are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this application, and should not be construed as limiting this application.

[0024] The sample delivery method according to an embodiment of this application is described below with reference to Figures 1-4.

[0025] Figure 1 is a flowchart of a sample delivery method according to an embodiment of this application. As shown in Figure 1, the sample delivery method includes the following steps: S1, delivering an isolation medium into a delivery pipeline 10 filled with a carrier liquid. The delivery pipeline 10 may be filled with a carrier liquid, which may be, but is not limited to, acetonitrile. An isolation medium may be delivered to the delivery pipeline 10 filled with the carrier liquid via a mass flow controller. The isolation medium may be an inert gas, such as, but not limited to, nitrogen or argon, or it may be a liquid that is immiscible with both the carrier liquid and the sample medium (e.g., but not limited to, fluorinated oil).

[0026] S2, the sample medium is introduced into the delivery pipeline 10 to form a sequential sequence of isolation medium, sample medium, and isolation medium from upstream to downstream. As some embodiments of this application, after the isolation medium is delivered to the delivery pipeline 10 filled with carrier liquid, the sample medium can be delivered between the upstream and downstream of the isolation medium so that the sample medium divides the isolation medium in the delivery pipeline 10 into two parts, forming a sequential sequence of isolation medium, sample medium, and isolation medium from upstream to downstream.

[0027] As some embodiments of this application, as shown in Figures 2 and 3, the delivery pipeline 10 may include a first sub-pipeline 11 and a second sub-pipeline 12. A switching valve 20 is connected between the first sub-pipeline 11 and the second sub-pipeline 12. The switching valve 20 may include a first channel 21 and a second channel 22. When delivering the isolation medium to the delivery pipeline 10 filled with carrier liquid, the first channel 21 is connected between the first sub-pipeline 11 and the second sub-pipeline 12, which can fill the first channel 21 with the isolation medium. That is, a portion of the isolation medium is located in the first channel 21 of the switching valve 20. Then, the sample medium can be introduced into the second channel 22 of the switching valve 20, and the switching valve 20 can be switched so that the second channel 22 and the first channel 21 are interchanged, so as to form a sequential sequence of isolation medium, sample medium, and isolation medium from upstream to downstream. This helps to reduce the risk of sample medium diffusion and cross-contamination.

[0028] Specifically, the sequence from upstream to downstream is formed as carrier liquid, isolation medium, sample medium, isolation medium, and carrier liquid.

[0029] S3, push the medium in the delivery pipeline 10 to make the sample medium reach the preset position. As some embodiments of this application, after delivering the isolation medium into the delivery pipeline 10 filled with carrier liquid, the injection pump can be connected to the delivery pipeline 10 by switching the high-pressure valve (or the mass flow controller can be separated from the delivery pipeline 10 and then the injection pump can be connected to the delivery pipeline 10, or other methods can be used, which are not specifically limited in this application). Then the medium in the delivery pipeline 10 can be pushed by the injection pump to make the sample medium reach the preset position. As some embodiments of this application, a sensor can be used to determine whether the sample medium has reached the preset position.

[0030] S4, the medium in the delivery pipeline 10 is pushed to a preset volume so that the sample medium is positioned at the detection position in the detection zone. Specifically, once the sample medium reaches the preset position, the medium in the delivery pipeline 10 can be pushed using an injection pump to push the preset volume, thus positioning the sample medium at the detection position in the detection zone. The preset volume is the fixed pipeline volume from the preset position to the detection position.

[0031] It should be noted that existing technologies use open-loop control logic to deliver samples, meaning the sample is "blindly pushed" into the detection zone based on a pre-calibrated total tubing volume and the pump's theoretical flow rate. Because the pump's flow rate fluctuates slightly due to back pressure changes, the tubing undergoes elastic deformation due to pressure, and fluid viscosity changes with temperature, these cumulative errors can cause the sample's final stopping position to deviate from the target point. Furthermore, the degree of deviation can vary in each experiment, severely impacting the reliability of the analytical results. Moreover, because the sample's final stopping position deviates from the target point, the center of the sample droplet may not be positioned within the most sensitive detection area of ​​the analytical instrument, resulting in weaker or distorted signal strength, reduced signal-to-noise ratio, and difficulties in subsequent accurate quantitative analysis. In addition, once the reactor, tubing, or system configuration is changed, the total volume of the entire tubing changes, requiring time-consuming and labor-intensive recalibration of the system before it can be used again.

[0032] In this application, instead of relying on volume estimation of the entire long-distance pipeline, the system captures the instant the sample medium reaches the preset position in real time and uses this event as the "zero point" reference for positioning. Starting from this reference point, only a short-distance, fixed-volume push is needed to accurately deliver the sample medium to the detection position. This transforms a long-distance transport problem susceptible to interference into a short-distance transport problem, which is a closed-loop control logic, improving transport accuracy and ensuring the reliability of analytical results. Moreover, it allows the sample medium center to remain in the most sensitive detection area of ​​the analytical instrument, thereby obtaining high-quality, high-signal-to-noise ratio raw data, which is beneficial for subsequent accurate quantitative analysis. Furthermore, even if the reactor, pipeline, or system configuration is changed later, there is no need to spend a lot of time and effort on recalibration. Only the fixed pipeline volume from the preset position to the detection position needs to be calibrated (i.e., only the preset volume needs to be calibrated, and even if the reactor, pipeline, or system configuration is changed, the preset volume generally remains unchanged). This allows the automated platform to adapt more flexibly to different experimental needs and improves the efficiency of equipment use.

[0033] Therefore, the sample delivery method proposed in this application can capture the moment when the sample medium arrives at the preset position and use this event as the positioning reference point. Starting from this reference point, only a short-distance, fixed-volume push is needed to accurately deliver the sample medium to the detection position, thereby transforming a long-distance delivery problem that is susceptible to interference into a short-distance delivery problem and improving the delivery accuracy.

[0034] In some embodiments of this application, delivering an isolation medium to a delivery pipeline 10 filled with a carrier liquid includes delivering a fixed amount of isolation medium to the delivery pipeline 10 filled with a carrier liquid.

[0035] As some embodiments of this application, a quantitative amount of isolation medium can be delivered to the delivery pipeline 10 filled with carrier liquid by controlling the volume of the isolation medium delivered by the mass flow controller, or a quantitative amount of isolation medium can be delivered to the delivery pipeline 10 filled with carrier liquid by controlling the delivery time of the isolation medium delivered by the mass flow controller.

[0036] As some embodiments of this application, a sensor can be installed on the delivery pipeline 10. When the isolation medium triggers the sensor, the delivery of the isolation medium is stopped, so as to deliver a certain amount of isolation medium to the delivery pipeline 10 filled with carrier liquid.

[0037] By supplying a fixed amount of isolation medium to the delivery pipeline 10 filled with carrier liquid, the volume of isolation medium supplied to the delivery pipeline 10 each time can be kept consistent, thereby ensuring that the volume of isolation medium used to isolate the sample medium is consistent each time, which is beneficial to improving the accuracy of sample medium delivery.

[0038] In some embodiments of this application, delivering a quantitative amount of isolation medium includes: delivering the isolation medium until the delivery stops when the isolation medium triggers the first sensor.

[0039] A first sensor can be installed on the delivery pipeline 10 to detect the isolation medium. In other words, the isolation medium can trigger the first sensor. The first sensor can be located downstream of the switching valve 20. During the delivery of the isolation medium to the delivery pipeline 10 filled with carrier liquid, the isolation medium will first fill the first channel 21 of the switching valve 20 and then trigger the first sensor. When the isolation medium triggers the first sensor, the delivery of the isolation medium stops.

[0040] This ensures that the volume of the isolation medium used to isolate the sample is consistent each time, is accurate and reliable, and is easy to operate, which helps to improve the accuracy of sample medium delivery.

[0041] In some embodiments of this application, the delivery of the isolation medium to the delivery pipeline 10 filled with carrier liquid further includes: placing a portion of the isolation medium within the first channel 21 of the switching valve 20. The delivery pipeline 10 may include a first sub-pipeline 11 and a second sub-pipeline 12. The switching valve 20 is connected between the first sub-pipeline 11 and the second sub-pipeline 12. The switching valve 20 may include a first channel 21 and a second channel 22. When the isolation medium is delivered to the delivery pipeline 10 filled with carrier liquid, the first channel 21 is connected between the first sub-pipeline 11 and the second sub-pipeline 12, which allows the isolation medium to fill the first channel 21. In other words, a portion of the isolation medium is placed within the first channel 21 of the switching valve 20.

[0042] Introducing the sample medium into the delivery pipeline 10 to form a sequential sequence of isolation medium, sample medium, and isolation medium from upstream to downstream includes: introducing the sample medium into the second channel 22 of the switching valve 20, and switching the switching valve 20 to swap the second channel 22 with the first channel 21 to form a sequential sequence of isolation medium, sample medium, and isolation medium from upstream to downstream.

[0043] The liquid injector can inject the sample medium into the second channel 22 of the switching valve 20 through the injection needle. The second channel 22 of the switching valve 20 can be constructed as a quantitative loop of the switching valve 20. After injecting the sample medium into the second channel 22 of the switching valve 20, the switching valve 20 can be switched so that the second channel 22 is interchanged with the first channel 21. That is, the second channel 22 is connected between the first sub-pipeline 11 and the second sub-pipeline 12 to form a sequence from upstream to downstream of isolation medium, sample medium, isolation medium, and so on. Specifically, the sequence from upstream to downstream is carrier liquid, isolation medium, sample medium, isolation medium, and carrier liquid.

[0044] This allows for convenient and reliable introduction of the sample medium into the delivery pipeline 10, forming a sequential sequence from upstream to downstream of isolation medium, sample medium, and isolation medium, which helps reduce the risk of sample medium dispersion and cross-contamination.

[0045] In some embodiments of this application, the second sensor triggers a first signal when it detects an isolation medium, and triggers a second signal when it detects both a sample medium and a carrier liquid. The sample delivery method further includes determining that the sample medium has reached a preset position when the second sensor detects a second transition from the first signal to the second signal. The second sensor may be located downstream of the first sensor, or upstream of the detection area and adjacent to the detection area.

[0046] It is understandable that by switching the switching valve 20 to swap the second channel 22 with the first channel 21, a sequential sequence is formed from upstream to downstream: carrier liquid, isolation medium, sample medium, isolation medium, carrier liquid. In other words, a sequential sequence is formed from downstream to upstream: carrier liquid, isolation medium, sample medium, isolation medium, carrier liquid.

[0047] As the medium is pushed into the delivery pipeline 10, the downstream carrier liquid and the isolation medium will sequentially trigger the second sensor, which will then generate a second signal and a first signal. This is the first transition from the second signal to the first signal. Then, the sample medium will trigger the second sensor to generate a second signal, which is the first transition from the first signal to the second signal. Then, the isolation medium upstream of the sample medium will trigger the second sensor to generate a first signal, which is the second transition from the second signal to the first signal. Then, the carrier liquid upstream of the sample medium will trigger the second sensor to generate a second signal, which is the second transition from the first signal to the second signal.

[0048] When the second transition from the first signal to the second signal is detected, it can be determined that the sample medium has reached the precise physical position of the detection end of the second sensor. This is the zero point position of the closed-loop control logic feedback. At the instant the second transition from the first signal to the second signal is detected, the continuous push stops, and all historical delivery data (such as the running time of the syringe pump, theoretical volume, etc.) are ignored. This logically cuts off the accumulated error, and only pushes the medium in the delivery pipeline 10 to the preset volume, so that the sample medium can be accurately pushed to the detection position of the detection area.

[0049] In some embodiments of this application, the isolation medium is constructed as a liquid or a gas. In some embodiments, the isolation medium is constructed as a gas, where the interfacial tension effectively suppresses sample dispersion, thus helping to ensure sample integrity. In some embodiments, the isolation medium is constructed as a liquid, where both the upstream and downstream sides of the sample medium are liquid, effectively reducing the risk of sample dispersion and cross-contamination, further helping to ensure sample integrity. Thus, the physical state of the isolation medium can be selected according to actual conditions and the type of sample medium to choose a more suitable isolation medium, which is beneficial for ensuring sample integrity.

[0050] In some embodiments of this application, binary digital signals are used to acquire the detection signals of the second sensor, and run-length encoding is used for processing.

[0051] In this context, the first signal can be denoted as 1 and the second signal can be denoted as 0, or the first signal can be denoted as 0 and the second signal can be denoted as 1. This article uses the example of the first signal being denoted as 1 and the second signal being denoted as 0.

[0052] It should be explained that, because the second sensor has a sampling frequency, a medium may be sampled multiple times as it passes through the detection end of the second sensor. For example, when a carrier liquid passes through the detection end of the second sensor, the second sensor may generate a second signal five times, which can be recorded as 00000. Therefore, as some embodiments of this application, when the carrier liquid, isolation medium, sample medium, isolation medium, and carrier liquid pass through the detection end of the second sensor in the following order from downstream to upstream, the signal generated by the second sensor can be recorded as 0000011111000001111100000.

[0053] After acquiring the detection signal from the second sensor using binary digital signals, run-length encoding can be used for processing to obtain a clear and stable step signal. Specifically, consecutive identical signal values ​​("0" or "1") are compressed and converted into data segments. For example, five second signals can be denoted as 50 or 05. In this case, 0000011111000001111100000 can be denoted as 5051505150 or 0515051505. This can significantly reduce the data length, speed up data transmission, reduce storage space occupation, and help improve the control accuracy of sample medium delivery.

[0054] In some embodiments of this application, after processing with run-length encoding, the first signal segment with a duration less than a preset threshold is merged and corrected. If a second signal segment precedes the first signal segment with a duration less than the preset threshold, it is merged into the preceding second signal segment. If a second signal segment does not precede the first signal segment with a duration less than the preset threshold, it is determined to be the first signal segment.

[0055] The preset threshold can be 3 consecutive sampling points, 4 consecutive sampling points, etc. This paper uses a preset threshold of 3 consecutive sampling points as an example. For instance, when a first signal segment with a duration of 2 consecutive sampling points (i.e., 11) occurs, this first signal segment can be merged and corrected. Specifically, if a second signal segment precedes the first signal segment with a duration less than the preset threshold, the first signal segment with a duration less than the preset threshold is merged into the preceding second signal segment. If a second signal segment does not precede the first signal segment with a duration less than the preset threshold, it is determined to be the first signal segment. This effectively filters out transient pseudo-signals and transforms the original, glitch-laden sensor signal into clear step data that accurately reflects the stable duration of each phase state. This provides a reliable basis for subsequent flow calculations and transport control, and is beneficial for improving the control accuracy of sample medium transport.

[0056] As some embodiments of this application, the sensors proposed in this application may be, but are not limited to, photoelectric phase sensors, capacitive sensors, ultrasonic sensors, miniature thermistor sensors based on differences in thermal conductivity, etc.

[0057] As some embodiments of this application, the preset volume can be pushed by controlling the injection pump to push for a fixed time or a fixed volume, and this application does not limit this.

[0058] As some embodiments of this application, the detection area can be the detection area of ​​an online MRI scanner.

[0059] To implement the above embodiments, this application proposes a computer-readable storage medium storing a control program for a sample delivery method thereon, which, when executed by a processor, implements the sample delivery method described above.

[0060] According to the computer-readable storage medium of this application, the instant when the sample medium arrives at the preset position can be captured and this event can be used as the positioning reference point. Starting from the reference point, only a short-distance, fixed-volume push is needed to accurately deliver the sample medium to the detection position, thereby transforming a long-distance transport problem susceptible to interference into a short-distance transport problem and improving the transport accuracy.

[0061] To implement the above embodiments, this application also proposes a sample delivery device, including a memory, a processor, and a control program for a sample delivery method stored in the memory and executable on the processor. When the processor executes the control program for the sample delivery method, the above-described sample delivery method is implemented.

[0062] According to the sample delivery device of this application, the instant when the sample medium arrives at the preset position can be captured and this event can be used as the positioning reference point. Starting from the reference point, only a short distance and a fixed preset volume push need to be performed to accurately deliver the sample medium to the detection position, thereby transforming a long-distance delivery problem that is susceptible to interference into a short-distance delivery problem and improving the delivery accuracy.

[0063] As shown in Figure 4, the sample delivery device may include at least one processor 1201, at least one communication interface 1202, at least one memory 1203, and at least one communication bus 1204. In the embodiments of this application, the number of processor 1201, communication interface 1202, memory 1203, and communication bus 1204 is at least one, and the processor 1201, communication interface 1202, and memory 1203 communicate with each other through the communication bus 1204.

[0064] The memory 1203 may be, but is not limited to, random access memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), electrically erasable programmable read-only memory (EEPROM), etc. The memory 1203 stores the program, and after receiving the execution instruction, the processor 1201 executes the program to implement the steps of the sample delivery method described in the above embodiments.

[0065] Processor 1201 may be an integrated circuit chip with signal processing capabilities. The aforementioned processor can be a general-purpose processor, including a Central Processing Unit (CPU), a Network Processor (NP), etc.; it can also be a Digital Signal Processor (DSP), an Application-Specific Integrated Circuit (ASIC), a Field-Programmable Gate Array (FPGA), or other programmable logic devices, discrete gate or transistor logic devices, or discrete hardware components. It can implement or execute the methods, steps, and logic block diagrams disclosed in the embodiments of this application. The general-purpose processor can be a microprocessor or any conventional processor.

[0066] It should be noted that the logic and / or steps represented in the flowchart or otherwise described herein, for example, can be considered as a sequenced list of executable instructions for implementing logical functions, and can be specifically implemented in any computer-readable medium for use by, or in conjunction with, an instruction execution system, apparatus, or device (such as a computer-based system, a processor-included system, or other system that can fetch and execute instructions from, an instruction execution system, apparatus, or device). For the purposes of this specification, "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transmit programs for use by, or in conjunction with, an instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of computer-readable media include: an electrical connection having one or more wires (electronic device), a portable computer disk drive (magnetic device), random access memory (RAM), read-only memory (ROM), erasable and editable read-only memory (EPROM or flash memory), fiber optic devices, and portable optical disc read-only memory (CDROM). Alternatively, the computer-readable medium may be paper or other suitable media on which the program can be printed, since the program can be obtained electronically, for example, by optically scanning the paper or other medium, followed by editing, interpreting, or otherwise processing as necessary, and then stored in a computer memory.

[0067] It should be understood that various parts of this application can be implemented using hardware, software, firmware, or a combination thereof. In the above embodiments, multiple steps or methods can be implemented using software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, it can be implemented using any one or a combination of the following techniques known in the art: discrete logic circuits having logic gates for implementing logical functions on data signals, application-specific integrated circuits (ASICs) having suitable combinational logic gates, programmable gate arrays (PGAs), field-programmable gate arrays (FPGAs), etc.

[0068] In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., indicating the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this application.

[0069] In the description of this application, "first feature" and "second feature" may include one or more of the features.

[0070] In the description of this application, "multiple" means two or more.

[0071] In the description of this application, the first feature being "above" or "below" the second feature may include the first and second features being in direct contact, or the first and second features being in contact through another feature between them.

[0072] In the description of this application, the terms "above," "over," and "on top" for the first feature and the second feature include the first feature being directly above or diagonally above the second feature, or simply indicate that the first feature is at a higher horizontal level than the second feature.

[0073] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0074] Although embodiments of this application have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the claims and their equivalents.

Claims

1. A sample delivery method, characterized in that, include: The isolation medium is delivered into a delivery pipeline filled with carrier liquid; the sample medium is introduced into the delivery pipeline to form a sequential sequence from upstream to downstream of the isolation medium, the sample medium, and the isolation medium; the medium in the delivery pipeline is pushed to bring the sample medium to a preset position; the medium in the delivery pipeline is pushed to a preset volume so that the sample medium is in the detection position of the detection zone.

2. The sample delivery method according to claim 1, characterized in that, The delivery of the isolation medium into the delivery pipeline filled with the carrier liquid includes: delivering a fixed amount of the isolation medium into the delivery pipeline filled with the carrier liquid.

3. The sample delivery method according to claim 2, characterized in that, The delivery of a fixed quantity of the isolation medium includes: delivering the isolation medium until the delivery stops when the isolation medium triggers the first sensor.

4. The sample delivery method according to claim 1, characterized in that, The delivery of the isolation medium into the delivery pipeline filled with carrier liquid further includes: positioning a portion of the isolation medium within the first channel of the switching valve; the introduction of the sample medium into the delivery pipeline to form a sequential sequence of the isolation medium, the sample medium, and the isolation medium from upstream to downstream includes: introducing the sample medium into the second channel of the switching valve, and switching the switching valve to swap the second channel with the first channel to form a sequential sequence of the isolation medium, the sample medium, and the isolation medium from upstream to downstream.

5. The sample delivery method according to claim 1, characterized in that, The second sensor triggers a first signal when it detects the isolation medium, and triggers a second signal when it detects both the sample medium and the carrier liquid; the sample delivery method further includes: when the second sensor detects a second jump from the first signal to the second signal, it determines that the sample medium has reached the preset position.

6. The sample delivery method according to claim 5, characterized in that, The isolation medium is constructed of liquid or gas.

7. The sample delivery method according to claim 5, characterized in that, The detection signal from the second sensor is acquired using binary digital signals and processed using run-length encoding.

8. The sample delivery method according to claim 7, characterized in that, After processing using run-length encoding, the first signal segment with a duration less than a preset threshold is merged and corrected. Specifically, if a second signal segment precedes the first signal segment with a duration less than the preset threshold, it is merged into the preceding second signal segment. If a second signal segment does not precede the first signal segment with a duration less than the preset threshold, it is determined to be the first signal segment.

9. A computer-readable storage medium, characterized in that, It stores a control program for a sample delivery method, which, when executed by a processor, implements the sample delivery method according to any one of claims 1-8.

10. A sample conveying device, characterized in that, The system includes a memory, a processor, and a control program for a sample delivery method stored in the memory and executable on the processor. When the processor executes the control program for the sample delivery method, it implements the sample delivery method according to any one of claims 1-8.

Images