Fresh and tooth-protecting toothpaste containing dandelion extract and preparation method of fresh and tooth-protecting toothpaste
By using a compound system of herbal plant extracts such as dandelion in toothpaste, the problem of relieving oral inflammation and bad breath in existing toothpastes has been solved, achieving 12-hour long-lasting freshness and highly effective antibacterial effect, while ensuring the stability and safety of the pump bottle.
Patent Information
- Application Number
- CN202610382220.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-03-26
- Publication Date
- 2026-05-05
AI Technical Summary
Existing toothpastes are not effective enough in relieving gum swelling and pain caused by oral inflammation, bad breath, and providing long-lasting fresh breath. Furthermore, the fluidity and stability of the toothpaste in pump-type bottle packaging are difficult to guarantee.
By using a compound system of dandelion extract with extracts of Ilex chinensis, Isatis indigotica, Chrysanthemum indicum and licorice, combined with a specific formula and packaging design, a refreshing toothpaste suitable for pump bottles is prepared to ensure the fluidity and stability of the paste. High-speed homogenization and vacuum degassing processes are used to improve the smoothness of extrusion.
It provides targeted relief for oral inflammation, lasts for 12 hours with fresh breath, has an antibacterial rate of over 99.99%, and meets the requirements for pump bottles, ensuring product safety and stability.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of oral care product technology, specifically to a refreshing toothpaste containing dandelion extract and its preparation method. Background Technology
[0002] As a daily oral hygiene product, toothpaste's formulas, efficacy, and packaging are constantly evolving. Currently, most commercially available toothpastes use traditional aluminum-plastic composite tube packaging, dispensed by squeezing. This type of packaging makes it difficult to completely squeeze out the last bit of toothpaste, potentially leading to waste, and the amount dispensed is also difficult to control.
[0003] In terms of efficacy, although many toothpastes on the market claim to freshen breath, reduce bad breath, and protect gums from inflammation, there is still a lack of specialized care products for specific problems such as swollen and painful gums, bad breath, and mucosal discomfort caused by traditional Chinese medicine concepts such as "oral inflammation." In particular, research and practice on the application of extracts from herbal plants with heat-clearing and detoxifying effects, such as dandelion, specifically in the field of oral care and their systematic combination with other gum-protecting ingredients are still insufficient.
[0004] Furthermore, toothpaste packaged in pump bottles faces higher requirements for the fluidity, stability, and extrusion performance after long-term storage. Improper formulation design can easily lead to stratification, thinning, or thickening of the paste, resulting in difficulty in pumping or poor form. Combining specific functional herbal extracts with a matrix formulation that meets the special physical properties of pump bottles, while ensuring that claimed effects such as fresh breath and antibacterial properties are experimentally verified, is a current technological challenge. Summary of the Invention
[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a refreshing toothpaste containing dandelion extract, which solves the technical problem that existing pump toothpastes are not effective in specifically relieving gum swelling and pain, bad breath and long-lasting fresh breath caused by oral inflammation.
[0006] To achieve the above objectives, the present invention adopts the following technical solution: A refreshing toothpaste containing dandelion extract, its formula composition by weight percentage includes: Dandelion extract 0.8%–1.5%, Hydrated silica 38%–42%, Glycerin 20%–24%, Sorbitol 6%–8%, Sodium lauryl sulfate 1.8%–2.2%, Sodium carboxymethyl cellulose 1.0%–1.4%, Steviosides 0.15%–0.25%, Sodium benzoate 0.1%–0.2%, Morning Dew Tea Mint Fragrance 1.0%–1.2% The remainder is deionized water.
[0007] As a preferred embodiment of the present invention, the dandelion extract is prepared by water extraction or alcohol extraction.
[0008] As a preferred embodiment of the present invention, the toothpaste is used to freshen breath, reduce oral odor, and / or clean and protect teeth.
[0009] As a preferred embodiment of the present invention, the formulation further includes a heat-clearing and anti-inflammatory plant extract compound system composed of Ilex chinensis extract, licorice extract, Chrysanthemum indicum extract and Isatis tinctoria extract.
[0010] As a preferred embodiment of the present invention, the formulation further includes zinc citrate.
[0011] As a preferred embodiment of the present invention, the toothpaste has different types, which are distinguished by adding exclusive colorants and / or thickeners, and the morphological stability of each type of toothpaste is maintained.
[0012] As a preferred embodiment of the present invention, the toothpaste is packaged in a pump bottle.
[0013] Another object of the present invention is to provide a method for preparing the aforementioned refreshing toothpaste containing dandelion extract, which includes the following steps: (1) Hydrated silica, sodium carboxymethyl cellulose and steviol glycosides are dry-mixed to prepare a premix; (2) Mix glycerin with some deionized water, heat and dissolve, add dandelion extract and stir well to make a liquid mixture; (3) Add the liquid mixture obtained in step (2) to the premix obtained in step (1) and stir at high speed to form a paste; (4) After cooling the paste obtained in step (3), add sodium lauryl sulfate, sodium benzoate and morning dew tea mint flavoring, stir evenly and then degas under vacuum. (5) Fill the degassed paste from step (4) into a pump bottle.
[0014] Compared with existing technologies, this invention has the following beneficial effects: First, its core heat-clearing and anti-inflammatory plant extract compound system (containing dandelion, isatis tinctoria, wild chrysanthemum, holly, and licorice extracts) can specifically relieve gingival redness, swelling, and pain, as well as oral mucosal discomfort caused by "oral inflammation," achieving comprehensive care for specific oral problems. Second, in vitro experiments have verified that this toothpaste has a long-lasting fresh breath and a strong antibacterial effect, with a statistically significant 12-hour breath freshness effect (P<0.05), and an antibacterial rate of over 99.99% against Staphylococcus aureus, Escherichia coli, and Candida albicans. Furthermore, its formula is specifically designed for pump packaging, ensuring good fluidity, stability, and smooth extrusion of the paste. At the same time, all safety indicators (such as microorganisms and heavy metals) meet national standards, ensuring the product's gentleness and safety. Detailed Implementation
[0015] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments and comparative examples. It should be understood that the specific embodiments described herein are for illustrative purposes only and do not constitute a limitation on the scope of protection of this invention. Example 1
[0016] This embodiment provides a refreshing toothpaste containing dandelion extract, the formula of which is as follows by weight percentage: 1.2% dandelion extract, 40% hydrated silica, 7% sorbitol, 22% glycerin, 2% sodium lauryl sulfate, 1.2% sodium carboxymethyl cellulose, 0.2% steviol glycosides, 0.5% xanthan gum, 0.15% sodium benzoate, 0.5% zinc citrate, 0.3% isatis extract, 0.3% wild chrysanthemum extract, 0.2% holly extract, 0.2% licorice extract, 3% butylene glycol, 1.1% morning dew tea-scented peppermint flavoring, CI 77891 0.2%, CI 73015 0.05%, and deionized water to 100%.
[0017] The method for preparing the refreshing toothpaste containing dandelion extract provided in this embodiment includes the following steps: Premix: Hydrated silica, sodium carboxymethyl cellulose, steviol glycosides, xanthan gum, zinc citrate, isatis extract, wild chrysanthemum extract, holly extract, licorice extract, CI 77891, and CI 73015 are mixed evenly in a dry powder mixer to prepare premix A.
[0018] Dissolving: In a mixing tank, add the prescribed amounts of deionized water, sorbitol, glycerin, and butylene glycol. Heat to 60-70°C and stir until completely dissolved. Cool to 45°C and add dandelion extract (ethanol extract). Stir until homogeneous liquid B is formed.
[0019] Preparation of paste: Slowly add premix A to liquid B, turn on the high-speed homogenizer, and stir for 15-20 minutes under vacuum conditions (-0.08 to -0.1 MPa) to form a uniform paste C.
[0020] Post-addition and degassing: Cool paste C to below 40°C, then add sodium lauryl sulfate, sodium benzoate, and morning dew tea-scented mint flavoring sequentially, and continue stirring for 10 minutes to ensure uniform dispersion. Then degas under a vacuum of -0.095 MPa for 5 minutes to obtain the final paste D.
[0021] Filling: The final paste D is filled into 150g capacity pump bottles using a filling machine to obtain the finished product.
[0022] Test Example 1 According to the "XYJC-SOP-CH-332 Oral Hygiene and Care Products Halitosis Reduction (Sulfide) Test Operation Instruction", the finished product of Example 1 was subjected to an in vitro 12-hour breath freshness test. The test principle and method are as follows: 1. Testing Principle This study simulated the in vitro production of volatile sulfur compounds (VSCS) in saliva by co-culturing oral hygiene products with saliva for 12 hours. The Hailmeterplus halitosis detector was used to measure the concentration of VSCS in oral gases using electrochemical principles, serving as an indicator of breath quality. Volatile sulfur compounds are characteristic substances of bad breath; lower levels of sulfides indicate fresher breath. This experiment uses the reduction in volatile sulfur compounds in breath before and after using oral hygiene products to determine whether the sample has the effect of freshening breath or reducing halitosis.
[0023] 2. Testing Methods 2.1 Experimental Design The experiment was set up with a sample group and a control group, with three replicates for each experimental group. The samples were diluted with pure water at a ratio of 1:1.6 to form the sample group, and pure water served as the control group.
[0024] 2.2 Sample Group Weigh 10 g (accurate to 0.1 g) of sample into a beaker, add 15 ml (accurate to 0.1 g) of water to prepare a 1:1.6 sample homogenate, stir well, and then transfer the sample homogenate to a 50 mL centrifuge tube. Centrifuge at 10000 r / min for 15 minutes and keep the supernatant for later use.
[0025] 2.3 Sample processing Six hydroxyapatite HAP samples that had formed a film in 2 hours were randomly divided into a sample group and a control group, with three samples in each group. The hydroxyapatite HAP samples in the sample group were soaked and placed in headspace vials, one vial per vial. The control group was treated with pure water in the same way.
[0026] 2.4 Overnight incubation (volatile sulfides) Add 3 mL of saliva culture medium solution, 5 mL of the test sample, and 100 μg / mL of methanethiol standard to each headspace vial, then incubate overnight (12 hours) in a 37°C water bath to generate volatile sulfides. Remove the incubated headspace vials from the water bath two days later.
[0027] 2.5 Detection of sulfide formation The sampling tube of the halitosis detector is connected to the headspace bottle. The total volume of sulfides is obtained by detecting the halitosis detector, and the total amount of sulfides produced is read and calculated.
[0028] 3. Evaluation Criteria A p-value < 0.05 indicates a significant difference between the sample and the control group, suggesting a noticeable effect on freshening breath or reducing halitosis. A p-value > 0.05 indicates no significant difference between the sample and the control group, suggesting no significant effect on freshening breath or reducing halitosis. The test results of the finished product obtained in Example 1 are shown in Table 1.
[0029] Table 1. In vitro 12-hour breath freshness test of Example 1
[0030] The test results showed that the sulfide content of the sample (diluted with pure water at a ratio of 1:1.6) after 12 hours of co-culturing with saliva was 271 ppb, while the sulfide content of the control group (pure water) was 1298 ppb; the difference was statistically significant (P<0.05), indicating that the sample has a 12-hour long-lasting effect of freshening breath and reducing halitosis.
[0031] Test Example 2 According to the "Evaluation Method for Antibacterial and Bacteriostatic Effects of Daily Chemical Products" (QB / T 2738-2023), the antibacterial effect of the finished product in Example 1 was tested, and the test results are shown in Table 2. Table 2 Antibacterial test results of Example 1
[0032] Note: QB / T2738-2023 "Evaluation Method for Antibacterial and Bacteriostatic Effects of Daily Chemical Products" stipulates that: if the antibacterial rate is ≥50%-90%, the product has an antibacterial effect; if the antibacterial rate is ≥90%, the product has a strong antibacterial effect.
[0033] Test results show that after 20 minutes of treatment, the original sample solution exhibited an inhibition rate of over 99.99% against Staphylococcus aureus, Escherichia coli, and Candida albicans, indicating a strong antibacterial effect.
[0034] Test Example 3 The safety and stability of the finished product of Example 1 were tested in accordance with the "Cosmetic Safety Technical Specifications" (2015 Edition) and GB / T 8372-2017. The test results are shown in Table 3. Table 3 Safety and stability tests of Example 1
[0035] The test results show that the total bacterial count, total mold and yeast count, thermotolerant coliforms, Staphylococcus aureus, Pseudomonas aeruginosa, mercury, arsenic, cadmium, lead, dioxane, pH value, hard particles, and the sum of diethylene glycol and ethylene glycol meet the requirements of the Announcement of the National Medical Products Administration on Issuing and Implementing the Regulations on the Management of Toothpaste Filing Data (No. 148 of 2023). The results of the paste and stability meet the requirements of GB / T8372-2017. Example 2
[0036] This embodiment provides a refreshing toothpaste containing dandelion extract, the formula of which is as follows by weight percentage: dandelion extract 0.8%, hydrated silica 38%, sorbitol 6%, glycerin 20%, sodium lauryl sulfate 1.8%, sodium carboxymethyl cellulose 1.0%, steviol glycosides 0.15%, xanthan gum 0.6%, sodium benzoate 0.1%, zinc citrate 0.4%, isatis extract 0.2%, wild chrysanthemum extract 0.2%, holly extract 0.3%, licorice extract 0.3%, butylene glycol 3%, morning dew tea-scented peppermint flavoring 1.0%, CI 77891 0.2%, CI 73015 0.05%, and deionized water to 100%.
[0037] The method for preparing the refreshing toothpaste containing dandelion extract provided in this embodiment includes the following steps: Premix: Hydrated silica, sodium carboxymethyl cellulose, steviol glycosides, xanthan gum, zinc citrate, isatis extract, wild chrysanthemum extract, holly extract, licorice extract, CI 77891, and CI 73015 are mixed evenly in a dry powder mixer to prepare premix A.
[0038] Dissolving: In a mixing tank, add the prescribed amounts of deionized water, sorbitol, glycerin, and butylene glycol, heat to 60-70°C and stir until completely dissolved to form a homogeneous liquid B.
[0039] Preparation of paste: Slowly add premix A to liquid B, turn on the high-speed homogenizer, and stir for 15-20 minutes under vacuum conditions (-0.08 to -0.1 MPa) to form a uniform paste C.
[0040] Post-addition and degassing: Cool paste C to below 40℃, then add sodium lauryl sulfate, sodium benzoate, morning dew tea-scented mint fragrance, and dandelion extract (ethanol extract) in sequence, and continue stirring for 10 minutes to ensure uniform dispersion. Subsequently, degas under a vacuum of -0.095 MPa for 5 minutes to obtain the final paste D.
[0041] Filling: The final paste D is filled into 150g capacity pump bottles using a filling machine to obtain the finished product.
[0042] The product of Example 2 was subjected to an in vitro 12-hour breath freshness test using the same test method, and the test results are shown in Table 4.
[0043] Table 4. In vitro 12-hour breath freshness test of Example 2
[0044] The test results showed that the sulfide content of the sample (diluted with pure water at a ratio of 1:1.6) after 12 hours of co-culturing with saliva was 276 ppb, while the sulfide content of the control group (pure water) was 1298 ppb; the difference was statistically significant (P<0.05), indicating that the sample has a 12-hour long-lasting effect of freshening breath and reducing halitosis.
[0045] The antibacterial test was performed on the finished product of Example 2 using the same test method, and the test results are shown in Table 5.
[0046] Table 5 Antibacterial test results of Example 2
[0047] Note: QB / T2738-2023 "Evaluation Method for Antibacterial and Bacteriostatic Effects of Daily Chemical Products" stipulates that: if the antibacterial rate is ≥50%-90%, the product has an antibacterial effect; if the antibacterial rate is ≥90%, the product has a strong antibacterial effect.
[0048] Test results show that after 20 minutes of treatment, the original sample solution exhibited an inhibition rate of over 99.99% against Staphylococcus aureus, Escherichia coli, and Candida albicans, indicating a strong antibacterial effect.
[0049] The finished product of Example 2 was subjected to safety and stability tests using the same test methods, and the test results are shown in Table 6.
[0050] Table 6 Safety and stability tests of Example 2
[0051] The test results show that the total bacterial count, total mold and yeast count, thermotolerant coliforms, Staphylococcus aureus, Pseudomonas aeruginosa, mercury, arsenic, cadmium, lead, dioxane, pH value, hard particles, and the sum of diethylene glycol and ethylene glycol meet the requirements of the Announcement of the National Medical Products Administration on Issuing and Implementing the Regulations on the Management of Toothpaste Filing Data (No. 148 of 2023). The results of the paste and stability meet the requirements of GB / T8372-2017. Example 3
[0052] This embodiment provides a refreshing toothpaste containing dandelion extract, the formula of which is as follows by weight percentage: 1.5% dandelion extract, 42% hydrated silica, 8% sorbitol, 24% glycerin, 2.2% sodium lauryl sulfate, 1.4% sodium carboxymethyl cellulose, 0.25% steviol glycosides, 0.4% xanthan gum, 0.2% sodium benzoate, 0.6% zinc citrate, 0.2% isatis extract, 0.3% wild chrysanthemum extract, 0.3% holly extract, 0.2% licorice extract, 2% butylene glycol, 1.2% morning dew tea-scented peppermint flavoring, CI 77891 0.2%, CI 73015 0.05%, and deionized water to 100%.
[0053] The method for preparing the refreshing toothpaste containing dandelion extract provided in this embodiment includes the following steps: Premix: Hydrated silica, sodium carboxymethyl cellulose, steviol glycosides, xanthan gum, zinc citrate, isatis extract, wild chrysanthemum extract, holly extract, licorice extract, CI 77891, and CI 73015 are mixed evenly in a dry powder mixer to prepare premix A.
[0054] Dissolving: In a mixing tank, add the prescribed amounts of deionized water, sorbitol, glycerin, and butylene glycol, heat to 60-70°C and stir until completely dissolved to form a homogeneous liquid B.
[0055] Preparation of paste: Slowly add premix A to liquid B, turn on the high-speed homogenizer, and stir for 15-20 minutes under vacuum conditions (-0.08 to -0.1 MPa) to form a uniform paste C.
[0056] Post-addition and degassing: Cool paste C to below 40℃, then add sodium lauryl sulfate, sodium benzoate, morning dew tea-scented mint fragrance, and dandelion extract (ethanol extract) in sequence, and continue stirring for 10 minutes to ensure uniform dispersion. Subsequently, degas under a vacuum of -0.095 MPa for 5 minutes to obtain the final paste D.
[0057] Filling: The final paste D is filled into 150g capacity pump bottles using a filling machine to obtain the finished product.
[0058] The product of Example 3 was subjected to an in vitro 12-hour breath freshness test using the same test method, and the test results are shown in Table 7.
[0059] Table 7. In vitro 12-hour breath freshness test of Example 3
[0060] The test results showed that the sulfide content of the sample (diluted with pure water at a ratio of 1:1.6) after 12 hours of co-culturing with saliva was 259 ppb, while the sulfide content of the control group (pure water) was 1298 ppb; the difference was statistically significant (P<0.05), indicating that the sample has a 12-hour long-lasting effect of freshening breath and reducing halitosis.
[0061] The antibacterial test was performed on the finished product of Example 3 using the same test method, and the test results are shown in Table 8.
[0062] Table 8 Antibacterial test results of Example 3
[0063] Note: QB / T2738-2023 "Evaluation Method for Antibacterial and Bacteriostatic Effects of Daily Chemical Products" stipulates that: if the antibacterial rate is ≥50%-90%, the product has an antibacterial effect; if the antibacterial rate is ≥90%, the product has a strong antibacterial effect.
[0064] Test results show that after 20 minutes of treatment, the original sample solution exhibited an inhibition rate of over 99.99% against Staphylococcus aureus, Escherichia coli, and Candida albicans, indicating a strong antibacterial effect.
[0065] The finished product of Example 3 was subjected to safety and stability tests using the same test methods, and the test results are shown in Table 9.
[0066] Table 9 Safety and stability tests of Example 3
[0067] The test results show that the total bacterial count, total mold and yeast count, thermotolerant coliforms, Staphylococcus aureus, Pseudomonas aeruginosa, mercury, arsenic, cadmium, lead, dioxane, pH value, hard particles, and the sum of diethylene glycol and ethylene glycol meet the requirements of the Announcement of the National Medical Products Administration on Issuing and Implementing the Regulations on the Management of Toothpaste Filing Data (No. 148 of 2023). The results of the paste and stability meet the requirements of GB / T8372-2017.
[0068] The above description is merely a preferred embodiment of the present invention. The scope of protection of the present invention is not limited to the above embodiments. All technical solutions falling within the scope of the present invention's concept are within the scope of protection of the present invention. It should be noted that for those skilled in the art, any improvements and modifications made without departing from the principles of the present invention should also be considered within the scope of protection of the present invention.
Claims
1. A refreshing toothpaste containing dandelion extract, characterized in that, By weight percentage, its formulation comprises: Dandelion extract 0.8%–1.5%, Hydrated silica 38%–42%, Glycerin 20%–24%, Sorbitol 6%–8%, Sodium lauryl sulfate 1.8%–2.2%, Sodium carboxymethyl cellulose 1.0%–1.4%, Steviosides 0.15%–0.25%, Sodium benzoate 0.1%–0.2%, Morning Dew Tea Mint Fragrance 1.0%–1.2% The remainder is deionized water.
2. The refreshing toothpaste containing dandelion extract according to claim 1, characterized in that, The dandelion extract is prepared by water extraction or alcohol extraction.
3. The refreshing toothpaste containing dandelion extract according to claim 1 or 2, characterized in that, The toothpaste is used to freshen breath, reduce bad breath, and / or clean and protect teeth.
4. The refreshing toothpaste containing dandelion extract according to claim 1 or 2, characterized in that, The formula also includes a compound system of heat-clearing and anti-inflammatory plant extracts composed of Ilex chinensis extract, licorice extract, chrysanthemum extract and isatis extract.
5. The refreshing toothpaste containing dandelion extract according to claim 1 or 2, characterized in that, The formula also includes zinc citrate.
6. The refreshing toothpaste containing dandelion extract according to claim 1 or 2, characterized in that, The toothpaste comes in different types, distinguished by the addition of specific colorants and / or thickeners, while maintaining the morphological stability of each type of toothpaste.
7. The refreshing toothpaste containing dandelion extract according to claim 1 or 2, characterized in that, The toothpaste is packaged in a pump bottle.
8. A method for preparing a refreshing toothpaste containing dandelion extract as described in claim 1 or 2, characterized in that, Includes the following steps: (1) Hydrated silica, sodium carboxymethyl cellulose and steviol glycosides are dry-mixed to prepare a premix; (2) Mix glycerin with some deionized water, heat and dissolve, add dandelion extract and stir well to make a liquid mixture; (3) Add the liquid mixture obtained in step (2) to the premix obtained in step (1) and stir at high speed to form a paste; (4) After cooling the paste obtained in step (3), add sodium lauryl sulfate, sodium benzoate and morning dew tea mint flavoring, stir evenly and then degas under vacuum. (5) Fill the degassed paste from step (4) into a pump bottle.