Tablet pressing device for tablet production

Abstract

A tablet pressing device for tablet production comprises a forming disc, a plurality of forming cavities are formed in the forming disc, lower supporting columns are movably arranged on the lower portions of the forming cavities in a penetrating mode respectively, upper tablet pressing columns are arranged on the upper portions of the forming cavities in a penetrating mode respectively, and the lower supporting columns and the upper tablet pressing columns are arranged in a matched mode; a plurality of communicated heat exchange channels are arranged in the forming disc on the outer side of the forming cavity, and inlets and outlets of the heat exchange channels are connected with a coolant leading-in pipeline and a coolant leading-out pipeline respectively. The mode that the upper pressing sheet column body and the lower pressing sheet column body are arranged on the upper side and the lower side of the forming cavity in a matched mode respectively is adopted, the forming cavity can be pushed out after pressing forming, the temperature of the forming cavity can be controlled by arranging the cooling agent guiding-in channel and the cooling agent guiding-out channel, and the phenomenon that the forming cavity is too hot due to overtemperature and other reasons in the pressing process is avoided. And black spots are generated on the surface.

Description

Technical Field

[0001] This application relates to a tablet compression apparatus for tablet production. Background Technology

[0002] Tablets are solid pharmaceutical preparations in the form of tablets, obtained by mixing and compressing active ingredients and excipients. They are widely used. During the compression process, some active ingredients (i.e., raw materials) have low melting points and are prone to eutectic reactions with low-melting-point excipients. Moreover, the physical state of the tablet core may change during the tableting process, affecting the stability of its external shape. Therefore, it is necessary to improve the existing tableting cavity to avoid damage to the tablet shape during compression, which would affect the accuracy of weight control and subsequent coating operations. Summary of the Invention

[0003] To address the aforementioned problems, this application proposes a tablet compression apparatus for tablet production, comprising a forming disc with several forming cavities. A lower support column is movably inserted into the lower portion of each forming cavity, and an upper compression column is inserted into the upper portion of each forming cavity, the lower support column and the upper compression column being configured in cooperation. Several interconnected heat exchange channels are arranged inside the forming disc outside the forming cavities, the inlets and outlets of which are connected to a coolant inlet pipe and a coolant outlet pipe, respectively. This application employs the configuration of upper and lower compression columns on the upper and lower sides of the forming cavity, allowing the tablet to be ejected after compression. Furthermore, the coolant inlet and outlet channels enable temperature control of the forming cavity, preventing issues such as black spots on the surface caused by overheating during compression.

[0004] Preferably, a lower support plate is provided at the lower part of the lower support column, and a lifting piston cylinder is provided below the lower support plate. The lifting piston rod extends out of the lifting piston cylinder and is fixedly connected to the middle of the lower support plate. An upper pressing plate is provided at the upper part of the upper pressing column, and an upper pressing piston cylinder is provided above the upper pressing plate. The upper pressing piston rod extends out of the upper pressing piston cylinder and is fixedly connected to the middle of the upper pressing plate.

[0005] Preferably, the heat exchange channel is spirally arranged along the height direction and is adjacent to at least one side of the molding cavity.

[0006] Preferably, the coolant is cooling water with a temperature of 5-10°C.

[0007] Preferably, the inner wall of the molding cavity, the upper pressing column, and the lower support column are each provided with an anti-sticking reinforcing coating. The anti-sticking reinforcing coating provided in this application has two main functions: firstly, it prevents adhesion; secondly, it increases the strength of the anti-sticking reinforcing coating during friction, thus preventing wear during use.

[0008] Preferably, the anti-stick reinforcing coating comprises the following components in parts by weight: acrylic resin: 50-60 parts; Epoxy resin: 4-6 parts; Nano-zirconia: 1-3 parts; Activated carbon: 0.5-1 part; Benzoyl peroxide: 1-1.5 parts.

[0009] Preferably, the activated carbon is modified in the following manner: 0.5-1 part of activated carbon is uniformly dispersed in 10-12 times its mass of methanol to obtain the first dispersion; Heat the first dispersion to 40-50℃, and add 1-1.5 parts of benzoyl peroxide dropwise until the addition is complete; The mixture is then heated to 60-70℃ and maintained for 2-3 hours to obtain a mixture of activated carbon and benzoyl peroxide. This application uses benzoyl peroxide to modify activated carbon, enabling the composite of benzoyl peroxide and activated carbon. This composite serves as the core for the later bonding of epoxy resin and acrylic resin, ensuring that the activated carbon is uniformly distributed within the coating. This allows the zirconia, combined with the activated carbon, to balance the flexibility of the coating during use, achieving a balance between rigidity and flexibility and improving overall wear resistance.

[0010] Preferably, the coating material is obtained by completely mixing the mixture, 1-3 parts of nano-zirconia, 4-6 parts of epoxy resin, and 50-60 parts of acrylic resin, wherein the epoxy resin and acrylic resin are calculated by net content. The coating material is repeatedly sprayed onto the inner wall of the tableting cavity, the outer side of the upper tableting column and the lower support column to form an outer coating. After the outer coating is heated and shaped at 130-150℃, it forms an anti-sticking and reinforcing coating.

[0011] Preferably, the thickness of the outer coating is 200-400μm, and the number of reciprocating sprays is not less than 5 times.

[0012] Preferably, the epoxy resin is an acetone solution of epoxy resin, and the mass concentration of the epoxy resin is 30-40 wt%. The acrylic resin is an acetone solution of acrylic resin, and the mass concentration of the acrylic resin is 30-40 wt%.

[0013] This application can bring the following beneficial effects: 1. This application adopts the form of upper pressing column and lower pressing column respectively set on the upper and lower sides of the molding cavity, so that it can be pushed out after pressing. By setting the coolant inlet channel and coolant outlet channel, the temperature of the molding cavity can be controlled to avoid problems such as black spots on the surface caused by overheating during the pressing process.

[0014] 2. The anti-stick reinforcing coating provided in this application has two main functions: one is to prevent adhesion, and the other is to increase the strength of the anti-stick reinforcing coating during friction, so as to avoid wear during use.

[0015] 3. This application uses benzoyl peroxide-modified activated carbon, which combines benzoyl peroxide and activated carbon. In the later stage, it serves as the core for the composite of epoxy resin and acrylic resin, ensuring that the activated carbon can be evenly distributed in the coating. This allows the zirconia, in combination with the activated carbon, to play a role in balancing the flexibility of the coating during use, achieving a balance between rigidity and flexibility, and improving the overall wear resistance. Attached Figure Description

[0016] The accompanying drawings, which are included to provide a further understanding of this application and form part of this application, illustrate exemplary embodiments and are used to explain this application, but do not constitute an undue limitation of this application. In the drawings: Figure 1 This is a schematic diagram of the structure of this application. Detailed Implementation

[0017] To clearly illustrate the technical features of this solution, the following detailed description, in conjunction with the accompanying drawings, will be provided.

[0018] For structural machinery, such as Figure 1 As shown, a tablet manufacturing compression apparatus includes a forming disc 1, on which a plurality of forming cavities 2 are arranged. A lower support column 3 is movably inserted through the lower part of each forming cavity 2, and an upper compression column 4 is inserted through the upper part of each forming cavity 2. The lower support column 3 and the upper compression column 4 are configured to cooperate with each other. A plurality of interconnected heat exchange channels 5 are arranged inside the forming disc 1 outside the forming cavity 2. The inlet and outlet of the heat exchange channels 5 are respectively connected to a coolant inlet pipe 6 and a coolant outlet pipe 7.

[0019] A lower support plate 8 is provided at the lower part of the lower support column 3. A lifting piston cylinder 9 is provided below the lower support plate 8. The lifting piston rod extends out of the lifting piston cylinder 9 and is fixedly connected to the middle of the lower support plate 8. An upper pressure plate 10 is provided at the upper part of the upper pressure column 4. An upper pressure piston cylinder 11 is provided above the upper pressure plate 10. The upper pressure piston rod 12 extends out of the upper pressure piston cylinder 11 and is fixedly connected to the middle of the upper pressure plate 10.

[0020] The heat exchange channel 5 is spirally arranged along the height direction and is adjacent to at least one side of the molding cavity 2. The coolant is cooling water with a temperature of 5-10℃. The inner wall of the molding cavity 2, the upper pressing column 4, and the lower support column 3 are respectively provided with an anti-sticking and reinforcing coating.

[0021] For the anti-sticking reinforcing coating, the anti-sticking reinforcing coating comprises the following substances in parts by weight: acrylic resin: 50-60 parts; Epoxy resin: 4-6 parts; Nano-zirconia: 1-3 parts; Activated carbon: 0.5-1 part; Benzoyl peroxide: 1-1.5 parts.

[0022] The anti-sticking reinforcing coating is prepared as follows: S1. Preparation of the mixture: The activated carbon is modified in the following manner: 0.5-1 part of activated carbon is uniformly dispersed in 10-12 times its mass of methanol to obtain the first dispersion; Heat the first dispersion to 40-50℃, and add 1-1.5 parts of benzoyl peroxide dropwise until the addition is complete; Then heat to 60-70℃ and continue for 2-3 hours to obtain a mixture of activated carbon and benzoyl peroxide.

[0023] S2. Raw material mixing: The coating material is obtained by completely mixing the mixture prepared in S1, 1-3 parts of nano-zirconia, 4-6 parts of epoxy resin, and 50-60 parts of acrylic resin, wherein the epoxy resin and acrylic resin are calculated by net content. The epoxy resin is an acetone solution of epoxy resin, and the mass concentration of the epoxy resin is 30-40 wt%. The acrylic resin is an acetone solution of acrylic resin, and the mass concentration of the acrylic resin is 30-40 wt%.

[0024] S3. Preparation of anti-sticking and reinforcing coating: The coating material is repeatedly sprayed onto the inner wall of the tableting cavity, the outer side of the upper tableting column and the lower support column to form an outer coating. After the outer coating is heated and shaped at 130-150℃, it forms an anti-sticking and reinforcing coating.

[0025] The outer coating has a thickness of 200-400μm and is sprayed repeatedly at least 5 times.

[0026] In practical use, the following example demonstrates the preparation of a tableting device with an anti-sticking and reinforcing coating, and the processing of the same batch of ibuprofen powder raw materials.

[0027] Example 1: S101. Preparation of the mixture: The activated carbon is modified in the following manner: 0.5 parts of activated carbon were uniformly dispersed in 10 times their weight of methanol to obtain the first dispersion; The first dispersion was heated to 40°C, and 1.5 parts of benzoyl peroxide were added dropwise until the addition was complete. Then heat to 60°C and continue for 3 hours to obtain a mixture of activated carbon and benzoyl peroxide.

[0028] S102. Raw material mixing: The coating material is obtained by completely mixing the mixture prepared in S1, 1 part of nano-zirconia, 4 parts of epoxy resin, and 50 parts of acrylic resin, wherein the epoxy resin and acrylic resin are calculated by net content. The epoxy resin is an acetone solution of epoxy resin, and the mass concentration of the epoxy resin is 30 wt%. The acrylic resin is an acetone solution of acrylic resin, and the mass concentration of the acrylic resin is 30 wt%.

[0029] S103. Preparation of anti-sticking reinforced coating: The coating material is repeatedly sprayed onto the inner wall of the tableting cavity, the outer side of the upper tableting column and the lower support column to form an outer coating. After the outer coating is heated and shaped at 130°C, it forms an anti-sticking and reinforcing coating.

[0030] The outer coating has a thickness of 200 μm and is applied in 5 reciprocating sprays.

[0031] The forming disc, lower support column, and upper tableting rod obtained by this method are designated as device number 1. Cooling water at 5°C is used as the coolant. 10,000 tablets are pressed, and the presence of forming defects is checked. Using device number 1, 31 tablets show obvious forming defects but no obvious black spots. Then, using device number 1 again without cooling water, an experiment is conducted, revealing 30 tablets with forming defects and 12 tablets with obvious black spots.

[0032] Example 2: S201. Preparation of the mixture: The activated carbon is modified in the following manner: One part of activated carbon was uniformly dispersed in 12 times its mass of methanol to obtain the first dispersion; Heat the first dispersion to 50°C, and add 1 part of benzoyl peroxide dropwise until the addition is complete; Then heat to 70°C and continue for 2 hours to obtain a mixture of activated carbon and benzoyl peroxide.

[0033] S202. Raw material mixing: The coating material is obtained by completely mixing the mixture prepared in S1, 3 parts of nano-zirconia, 6 parts of epoxy resin, and 60 parts of acrylic resin, wherein the epoxy resin and acrylic resin are calculated by net content. The epoxy resin is an acetone solution of epoxy resin, and the mass concentration of the epoxy resin is 40 wt%. The acrylic resin is an acetone solution of acrylic resin, and the mass concentration of the acrylic resin is 40 wt%.

[0034] S203. Preparation of anti-sticking reinforced coating: The coating material is repeatedly sprayed onto the inner wall of the tableting cavity, the outer side of the upper tableting column and the lower support column to form an outer coating. After the outer coating is heated and shaped at 150°C, it forms an anti-sticking and reinforcing coating.

[0035] The outer coating has a thickness of 400 μm and is sprayed 10 times.

[0036] The forming disc, lower support column, and upper tableting rod obtained by this method are designated as device number 2. Cooling water at 5°C is used. 10,000 tablets are pressed, and the tablets are inspected for forming defects. Using device number 2, 26 tablets showed obvious forming defects but no obvious black spots.

[0037] Make the following comparative example: Comparative Example 1: S301. Raw material mixing: The coating material is obtained by completely mixing 0.5 parts activated carbon, 5 parts methanol, 1.5 parts benzoyl peroxide, 1 part nano zirconium oxide, 4 parts epoxy resin, and 50 parts acrylic resin. The epoxy resin and acrylic resin are calculated by net content. The epoxy resin is an acetone solution of epoxy resin, and the mass concentration of the epoxy resin is 30 wt%. The acrylic resin is an acetone solution of acrylic resin, and the mass concentration of the acrylic resin is 30 wt%.

[0038] S302. Preparation of anti-sticking reinforced coating: The coating material is repeatedly sprayed onto the inner wall of the tableting cavity, the outer side of the upper tableting column and the lower support column to form an outer coating. After the outer coating is heated and shaped at 130°C, it forms an anti-sticking and reinforcing coating.

[0039] The outer coating has a thickness of 200 μm and is applied in 5 reciprocating sprays.

[0040] The forming disc, lower support column, and upper tableting rod obtained by this method are designated as device number 3. Cooling water at 5°C is used as the coolant. 10,000 tablets are pressed, and the tablets are inspected for forming defects. Using device number 3, 50 tablets show obvious forming defects but no obvious black spots.

[0041] Comparative Example 2: S401. Preparation of the mixture: The activated carbon is modified in the following manner: 0.5 parts of activated carbon were uniformly dispersed in 10 times their weight of methanol to obtain the first dispersion; The first dispersion was heated to 40°C, and 1.5 parts of benzoyl peroxide were added dropwise until the addition was complete. Then heat to 60°C and continue for 3 hours to obtain a mixture of activated carbon and benzoyl peroxide.

[0042] S402. Raw material mixing: The coating material is obtained by completely mixing the mixture prepared in S1, 4 parts of epoxy resin, and 50 parts of acrylic resin, wherein the epoxy resin and acrylic resin are calculated by net content. The epoxy resin is an acetone solution of epoxy resin, and the mass concentration of the epoxy resin is 30 wt%. The acrylic resin is an acetone solution of acrylic resin, and the mass concentration of the acrylic resin is 30 wt%.

[0043] S403. Preparation of anti-sticking reinforced coating: The coating material is repeatedly sprayed onto the inner wall of the tableting cavity, the outer side of the upper tableting column and the lower support column to form an outer coating. After the outer coating is heated and shaped at 130°C, it forms an anti-sticking and reinforcing coating.

[0044] The outer coating has a thickness of 200 μm and is applied in 5 reciprocating sprays.

[0045] The forming disc, lower support column, and upper tableting rod obtained by this method are designated as device number 4. Cooling water at 5°C is used. 10,000 tablets are pressed, and the tablets are inspected for forming defects. Using device number 4, 67 tablets showed obvious forming defects but no obvious black spots.

[0046] The various embodiments in this specification are described in a progressive manner. Similar or identical parts between embodiments can be referred to mutually. Each embodiment focuses on describing the differences from other embodiments. In particular, the system embodiments are basically similar to the method embodiments, so the description is relatively simple; relevant parts can be referred to the descriptions in the method embodiments.

[0047] The above are merely embodiments of this application and are not intended to limit the scope of this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of the claims of this application.

Claims

1. A tablet compression apparatus for tablet production, characterized in that: It includes a forming disc with several forming cavities. A lower support column is movably inserted through the lower part of each forming cavity, and an upper pressing column is inserted through the upper part of each forming cavity. The lower support column and the upper pressing column are configured to cooperate with each other. Several interconnected heat exchange channels are provided inside the forming disc outside the forming cavities. The inlet and outlet of each heat exchange channel are connected to a coolant inlet pipe and a coolant outlet pipe, respectively.

2. The tablet manufacturing compression apparatus according to claim 1, characterized in that: A lower support plate is provided at the lower part of the lower support column, and a lifting piston cylinder is provided below the lower support plate. The lifting piston rod extends out of the lifting piston cylinder and is fixedly connected to the middle of the lower support plate. An upper pressing plate is provided at the upper part of the upper pressing column, and an upper pressing piston cylinder is provided above the upper pressing plate. The upper pressing piston rod extends out of the upper pressing piston cylinder and is fixedly connected to the middle of the upper pressing plate.

3. The tablet manufacturing compression apparatus according to claim 1, characterized in that: The heat exchange channel is spirally arranged along the height direction and is adjacent to at least one side of the molding cavity.

4. A tablet manufacturing compression apparatus according to claim 1, characterized in that: The coolant is cooling water with a temperature of 5-10℃.

5. A tablet manufacturing compression apparatus according to claim 1, characterized in that: The inner wall of the molding cavity, the upper pressing column, and the lower support column are respectively provided with an anti-sticking and reinforcing coating.

6. A tablet manufacturing compression apparatus according to claim 5, characterized in that: The anti-stick reinforcing coating comprises the following substances in parts by weight: acrylic resin: 50-60 parts; Epoxy resin: 4-6 parts; Nano-zirconia: 1-3 parts; Activated carbon: 0.5-1 part; Benzoyl peroxide: 1-1.5 parts.

7. A tablet manufacturing compression apparatus according to claim 6, characterized in that: The activated carbon is modified in the following manner: 0.5-1 part of activated carbon is uniformly dispersed in 10-12 times its mass of methanol to obtain the first dispersion; Heat the first dispersion to 40-50℃, and add 1-1.5 parts of benzoyl peroxide dropwise until the addition is complete; Then heat to 60-70℃ and continue for 2-3 hours to obtain a mixture of activated carbon and benzoyl peroxide.

8. A tablet manufacturing compression apparatus according to claim 7, characterized in that: The coating material is obtained by completely mixing the mixture, 1-3 parts of nano-zirconia, 4-6 parts of epoxy resin, and 50-60 parts of acrylic resin, wherein the epoxy resin and acrylic resin are calculated by net content. The coating material is repeatedly sprayed onto the inner wall of the tableting cavity, the outer side of the upper tableting column and the lower support column to form an outer coating. After the outer coating is heated and shaped at 130-150℃, it forms an anti-sticking and reinforcing coating.

9. A tablet manufacturing compression apparatus according to claim 8, characterized in that: The outer coating has a thickness of 200-400μm and is sprayed repeatedly at least 5 times.

10. A tablet manufacturing compression apparatus according to claim 8, characterized in that: The epoxy resin is an acetone solution of epoxy resin, and the mass concentration of the epoxy resin is 30-40 wt%. The acrylic resin is an acetone solution of acrylic resin, and the mass concentration of the acrylic resin is 30-40 wt%.

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