Amide compound as well as preparation method and agronomic application thereof

Abstract

Relates to the field of pesticide chemistry, and provides an amide compound, a preparation method and agricultural application thereof, and a biological stimulant. The compound can effectively promote seed germination, increase crop yield, regulate plant growth, enhance plant disease resistance and perform abiotic stress management on plants.

Description

Amide compounds and their preparation methods and agricultural applications

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims the benefit of Chinese patent application No. 202311268630.2 filed on September 28, 2023, the contents of which are incorporated herein by reference. Technical Field

[0003] The present invention relates to the field of pesticide chemistry, and in particular to an amide compound, a preparation method thereof, and agricultural applications thereof. Background Art

[0004] Globally, weed damage causes $95 billion in economic losses to food production annually, and the vast seed bank in the soil is the direct cause of this damage. Germination is essential for the life cycle of seed plants. Promoting seed germination can improve germination rates, reduce seed usage in agricultural production, increase the inoculation rates of Cistanche deserticola and Cynomorium songaricum, and protect wild Chinese medicinal resources. Furthermore, post-emergence herbicides can be applied to weeds after they emerge, thereby controlling them.

[0005] Strigolactones are a class of natural products containing alkenyl ether butenoic acid lactone structural units isolated from plants. Studies have shown that strigolactone compounds can not only promote the germination of seeds of root parasitic weeds such as Orobancha and Striga, but also promote the germination of arbuscular mycorrhizal fungi spores and the branching of hyphae. In addition, as a newly discovered plant hormone, strigolactone compounds can also regulate multiple processes of plant growth and development, such as inhibiting plant branching, controlling the germination of axillary buds, inhibiting the growth of plant lateral roots and promoting the elongation of the main root ("Strigolactones: plant hormones with promising features" (Bouwmeester, HJ etc., "Angew. Chem. Int. Ed.", 2019, Vol. 58, p12778-12786). Existing strigolactone compounds are difficult to obtain and have poor stability, which limits their application in agricultural growth.

[0006] "Tentative molecular mechanism for germination stimulation of striga and orobanche seeds by strigol and its synthetic analogs" (Mangnus, EM; Zwanenburg, B.; "J. Agric. Food Chem.", 1992, volume 40, p1066-1070) points out that the alkenyl ether butenoic acid lactone structural unit in the striga lactone compounds is crucial to maintaining the activity of the compound. If the enol ether bond is replaced by a methylene group, the compound will lose its activity. At present, the reported striga lactone analogs or mimetics also contain alkenyl ether butenoic acid lactone structural units with poor stability (such as WO2018060865A1 and WO2012146374A3). This structural fragment is also an important factor that causes the poor stability of such compounds and restricts their field application.

[0007] Currently, most highly active strigolactone agonists, such as nijmegen-1 and MP1, cannot be used in actual production due to their poor stability. Therefore, a new compound with good stability and can be effectively applied in agricultural growth is needed.

[0008] Summary of the Invention

[0009] The purpose of the present invention is to provide a novel amide compound having at least one of the following functions: seed germination, increasing crop yield, regulating plant growth, controlling soil microbial population structure and improving soil fertility.

[0010] In order to achieve the above object, the first aspect of the present invention provides an amide compound having a structure shown in formula (I):

[0011] Wherein, in formula (I),

[0012] R 1 and R 2 are each independently selected from H, substituted or unsubstituted C 1-12 Alkyl, substituted or unsubstituted C 3-12 Cycloalkyl, a substituted or unsubstituted C containing at least one heteroatom selected from N, O and S; 1-8 heterocyclic ring, wherein R 7 、R 8 、R 9 、R 10 and R 11Each is independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 Alkyl, C 3-6 Cycloalkyl, C substituted by 1-9 halogen 1-6 Alkyl, C 1-6 Alkoxy, C substituted by 1-9 halogen 1-6 Alkoxy, C 1-6 Alkylthio, C substituted by 1-9 halogen 1-6 Alkylthio, -COO-C 1-6 Alkyl and -S(O)2-C 1-6 Alkyl, or R 7 、R 8 、R 9 、R 10 、R 11 Any two adjacent ones of the rings are cyclized together to form a 3-8 membered ring structure;

[0013] And R 1 and R 2 The optional substituents are each independently selected from C 1-12 Alkyl, phenyl;

[0014] R 3 、R 4 、R 5 and R 6 Each independently selected from H, C 1-12 The alkyl group and C 3-12 Cycloalkyl;

[0015] n is 0, 1, 2, 3 or 4;

[0016] X is O, S, -S(O)- or -S(O)2-; Y is O, S, CH2, NH or -N(CH3)-.

[0017] The second aspect of the present invention provides a method for preparing the amide compound described in the first aspect, the method comprising: contacting a compound represented by formula (V-1) with a compound represented by formula (V-2);

[0018] Wherein, the substitution of the substituents in formula (V-1) and formula (V-2) corresponds to the same substitution in the amide compounds described in the first aspect, and one of Z1 and Z2 is -Br and the other is -XH, and the definition of X corresponds to the same definition in the amide compounds described in the first aspect.

[0019] The third aspect of the present invention provides a method for preparing the amide compound described in the first aspect, the method comprising: subjecting the compound represented by formula (II) to a coupling reaction with the compound represented by formula (III);

[0020] The substitution conditions of the substituents in formula (III) and formula (II) are the same as those in the amide compounds described in the first aspect.

[0021] The fourth aspect of the present invention provides the use of the amide compound described in the first aspect in agronomy.

[0022] A fifth aspect of the present invention provides a biostimulant, which contains an effective amount of plant growth regulating at least one of the amide compounds described in the first aspect, and optionally contains an auxiliary material.

[0023] The amide compounds provided by the present invention can regulate the soil microbial population structure and improve soil fertility.

[0024] The amide compounds provided by the present invention can effectively promote seed germination, regulate plant growth and development, and improve the quality and yield of crops.

[0025] In particular, in the compound having the structure shown in formula (I) provided by the present invention, when X and Y are both O, the compound provided by the present invention can effectively increase the yield of crops.

[0026] In the compound having the structure shown in formula (I) provided by the present invention, when X and Y are not both O, the compound provided by the present invention can effectively promote seed germination, regulate plant growth and development, and improve crop quality and yield.

[0027] In particular, compared with the compounds containing alkenyl ether-substituted butenoic acid lactone ring structures in the prior art, the amide compounds provided by the present invention not only have good seed germination promoting activity, but also have good stability, plant growth regulating activity and crop yield promoting activity, and can therefore be well applied in the field. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 shows the 1×10 -7 mol / L of compound 1; FIG2 is a seed germination diagram of the melon seeds provided by the present invention after being treated with a blank control (CK); FIG3 is a seed germination diagram of the wheat seeds provided by the present invention after being treated with a blank control (CK); FIG4 is a seed germination diagram of the wheat seeds provided by the present invention after being treated with 1 ppm of compound 1; FIG5 is a seed germination diagram of the wheat seeds provided by the present invention after being treated with 1 ppm of compound 768; FIG6 is a seed germination diagram of the wheat provided by the present invention after being treated with 1×10 -6mol / L of compound 1 after drought resistance of wheat; FIG7 is a diagram of the drought resistance of wheat provided by the present invention after being treated with a blank control (CK); FIG8 is a diagram of the drought resistance of corn experimental field provided by the present invention after being treated with a blank control (shown in A in FIG8 ) and 4×10 -5 mol / L of compound 1 (shown in B in FIG8 ); FIG9 is a graph of the root growth of Arabidopsis thaliana provided by the present invention after being treated with a blank control; FIG10 is a graph of the root growth of Arabidopsis thaliana provided by the present invention after being treated with 1 μM compound 880; FIG11 is a graph of the growth of wheat provided by the present invention after being treated with a blank control; FIG12 is a graph of the growth of wheat provided by the present invention after being treated with 1 ppm of compound 1. DETAILED DESCRIPTION

[0029] The endpoints of the ranges and any values ​​disclosed herein are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoints of each range, the endpoints of each range and individual point values, and the individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered to be specifically disclosed herein.

[0030] The C of the present invention 1-12 The alkyl group in the present invention refers to an alkyl group with a total carbon number of 1 to 12, including a straight-chain alkyl group and a branched-chain alkyl group, for example, a straight-chain alkyl group or a branched-chain alkyl group with a total carbon number of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12, for example, a methyl group, an ethyl group, a n-propyl group, an isopropyl group, a n-butyl group, an isobutyl group, a tert-butyl group, a n-pentyl group, an isopentyl group, a n-hexyl group, etc. 1-6 Alkyl", "C 1-4 Alkyl" and "C 1-3 The "alkyl group" has a similar explanation, except that the total number of carbon atoms is different.

[0031] The C of the present invention 3-12 The cycloalkyl group is a cycloalkyl group with a total carbon number of 3 to 12, such as a cycloalkyl group with a total carbon number of 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12. There is no particular requirement for the number of carbon atoms in the ring, and the cycloalkyl group may be, for example, a cyclopropyl group, a methylcyclopropyl group, an ethylcyclopropyl group, a cyclopentyl group, a methylcyclopentyl group, a cyclohexyl group, etc. 3-8 Cycloalkyl", "C 3-6 The cycloalkyl group" has a similar explanation, except that the number of carbon atoms is different.

[0032] The present invention refers to a "C containing at least one heteroatom selected from N, O and S" 1-8The term "heterocycle" refers to a cyclic structure having a total of 1 to 8 carbon atoms, wherein the atoms forming the ring contain at least one heteroatom selected from N, O and S. The structure may be saturated or unsaturated. For example, the structure may be a three-membered ring, a four-membered ring, a five-membered ring, a six-membered ring, a seven-membered ring, an eight-membered ring, etc.

[0033] The halogens mentioned in the present invention include fluorine, chlorine, bromine and iodine.

[0034] The C substituted by 1-9 halogens of the present invention 1-6 The alkyl group represents C 1-6 1-9 H atoms on the alkyl group are replaced by halogen, and 1, 2 or 3 H atoms on the same carbon can be replaced, or H atoms on different carbons can be replaced, for example, trifluoromethyl, difluoromethyl, monofluoromethyl, monofluoroethyl, difluoroethyl, trifluoroethyl, etc.

[0035] The C of the present invention 1-6 The alkoxy group represents -OR a The group shown, where R a C 1-6 of alkyl.

[0036] The C of the present invention 1-6 The alkylthio group represents -SR b The group shown, where R b C 1-6 of alkyl.

[0037] The C substituted by 1-9 halogens of the present invention 1-6 Alkoxy represents C 1-6 1-9 H atoms on the alkoxy group are replaced by halogen, which can be 1, 2 or 3 H atoms on the same carbon or H atoms on different carbons. 1-6 "Alkylthio" has a similar definition.

[0038] The "-COO-C 1-6 "Alkyl" means that the ester group is directly connected to the parent core structure, and the other end of the single bond O atom on the ester group is connected to the C 1-6 Alkyl connection.

[0039] The "-S(O)2-C 1-6 The term "alkyl" refers to a sulfone group that is directly connected to the parent core structure.

[0040] The "R 7 、R 8 、R 9 、R 10 、R 11 Any two adjacent rings in the ring are cyclized together to form a 3-8 membered ring structure" indicates R7 、R 8 、R 9 、R 10 and R 11 Any two adjacent groups are cyclized together with the two carbon atoms in the benzene ring structure in which they are located to form a ring containing 3, 4, 5, 6, 7 or 8 atoms.

[0041] When the present invention does not limit the specific substitution position, the "substituted or unsubstituted" in the present invention means that the group can be substituted by a substituent defined later, or it can be a group without a substituent defined later; if it is substituted by a substituent, the substituent can be located at any position that can be substituted. For example, the substituted or unsubstituted C 1-12 The alkyl group represents 1-12 Any substitutable position on the alkyl group can be substituted.

[0042] In the present invention, the wavy line indicates the connection position, e.g. The wavy line shown indicates the connection position, that is, the group is connected to the parent core structure through a chemical bond at the site where the wavy line is located.

[0043] “-(CH2) z -phenyl" means that the methylene group is directly connected to the mother core structure and the terminal group is a phenyl group.

[0044] The term "unsaturated five-membered ring group containing a heteroatom selected from Class B" means that the group is a five-membered ring group, and the five-membered ring group is an unsaturated group, contains at least one double bond structure, and the ring atoms of the five-membered ring group contain at least one heteroatom selected from Class B heteroatoms. The term "unsaturated six-membered ring group containing a heteroatom selected from Class B heteroatoms" has a similar interpretation.

[0045] The “saturated four-membered ring group containing a Class B heteroatom” means that the group is a four-membered ring group, the four-membered ring group is a saturated group, and the ring atoms of the four-membered ring group contain at least one heteroatom selected from Class B heteroatoms.

[0046] “C 4-8 The term "saturated cycloalkyl" refers to a cycloalkyl group containing 4 to 8 carbon atoms, and the cycloalkyl group is a saturated cycloalkyl group, and the ring atoms are all C atoms.

[0047] The present invention has no particular requirements for the site at which "benzothiazolyl, benzoxazolyl, benzopyrazolyl, phenylthienyl, N-methyl-benzopyrrolyl" groups, etc., are attached to the parent core structure; they may be attached to the parent core structure at any position capable of forming a stable chemical bond. In other words, any hydrogen residue at any position may be removed to form the aforementioned groups, which are then attached to the parent core structure.

[0048] As mentioned above, the first aspect of the present invention provides an amide compound.

[0049] Preferably, in formula (1), X and Y are not O at the same time.

[0050] Preferably, in formula (I), R 1 and R 2 Each independently selected from H, C 1-6 Alkyl, -(CH2) z -phenyl, an unsaturated five-membered ring group containing a B-type heteroatom, a saturated four-membered ring group containing a B-type heteroatom, an unsaturated six-membered ring group containing a B-type heteroatom, C 4-8 saturated cycloalkyl, benzothiazolyl, benzoxazolyl, benzopyrazolyl, benzothienyl, N-methyl-benzopyrrolyl, z is an integer of 1-6; each of the B-type heteroatoms is independently selected from at least one of O, S, and N; and optionally, the B-type heteroatoms contain C 1-3 As a substituent, R 7 、R 8 、R 9 、R 10 and R 11 Each is independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 Alkyl, C 3-6 Cycloalkyl, C substituted by 1-6 halogen 1-6 Alkyl, C 1-6 Alkoxy, C substituted by 1-6 halogen 1-6 Alkoxy, C 1-6 Alkylthio, C substituted by 1-3 halogen 1-6 Alkylthio, -COO-C 1-6 Alkyl and -S(O)2-C 1-6 Alkyl, or R 7 、R 8 、R 9 Any two adjacent rings in the ring form a C with or without an O atom. 3-6 A saturated cycloalkane structure; or R 7 、R 8 、R 9 Any two adjacent rings are cyclized together to form a C containing or not containing type A heteroatom 3-6 The unsaturated cycloalkane structure, the A-type heteroatom is selected from at least one of O, S, and N, and optionally, the A-type heteroatom contains C 1-3 An alkyl group as a substituent; R 3 、R 4 、R 5 and R6 Each independently selected from H, C 1-6 The alkyl group and C 3-6 n is 0, 1, 2 or 3; X is S, -S(O)- or -S(O)2-; Y is O, NH, -CH2- or -N(CH3)-.

[0051] According to a particularly preferred embodiment, in formula (I), R 1 for Among them, R 7 、R 8 、R 9 、R 10 and R 11 Each is independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 Alkyl, C 3-6 Cycloalkyl, C substituted by 1-6 halogen 1-6 Alkyl, C 1-6 Alkoxy, C substituted by 1-6 halogen 1-6 Alkoxy, C 1-6 Alkylthio, C substituted by 1-3 halogen 1-6 Alkylthio, -COO-C 1-6 Alkyl and -S(O)2-C 1-6 Alkyl, or R 7 、R 8 、R 9 Any two adjacent rings in the ring form a C with or without an O atom. 3-6 A saturated cycloalkane structure; or R 7 、R 8 、R 9 Any two adjacent rings are cyclized together to form a C containing or not containing type A heteroatom 3-6 The unsaturated cycloalkane structure, the A-type heteroatom is selected from at least one of O, S, and N, and optionally, the A-type heteroatom contains C 1-3 An alkyl group as a substituent; R 2 、R 5 and R 6 Each is independently selected from H, methyl, ethyl, n-propyl, isopropyl, tert-butyl; or R 2 is phenyl; R 3 and R 4 are all H; n is 0, 1 or 2; X is S, -S(O)- or -S(O)2-; Y is O, NH, -CH2- or -N(CH3)-.

[0052] According to a more preferred embodiment, the compound represented by formula (I) has the structure of the compound represented by formula (IA):

[0053] Wherein, in formula (IA), n, X, Y, R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 The replacement is as follows:

[0054] Compound 1: n is 0, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 2: n is 0, X is S, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 3: n is 0, X is S, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 4: n is 0, X is S, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 5: n is 0, X is S, Y is O, R 6 For Me, R 7 Cl, R 2 、R3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 6: n is 0, X is S, Y is O, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 7: n is 0, X is S, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 8: n is 0, X is S, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 9: n is 0, X is S, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 10: n is 0, X is S, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11All are H; Compound 11: n is 0, X is S, Y is O, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 12: n is 0, X is S, Y is O, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 13: n is 0, X is S, Y is O, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 14: n is 0, X is S, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 15: n is 0, X is S, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 16: n is 0, X is S, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5、R 7 、R 8 、R 10 、R 11 All are H; Compound 17: n is 0, X is S, Y is O, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 18: n is 0, X is S, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 19: n is 0, X is S, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 20: n is 0, X is S, Y is O, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 21: n is 0, X is S, Y is O, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 22: n is 0, X is S, Y is O, R 6 For Me, R9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 23: n is 0, X is S, Y is O, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 24: n is 0, X is S, Y is O, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 25: n is 0, X is S, Y is O, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 26: n is 0, X is S, Y is O, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 27: n is 0, X is S, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R9 、R 10 、R 11 All are H; Compound 28: n is 0, X is S, Y is O, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 29: n is 0, X is S, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 30: n is 0, X is S, Y is O, R 6 For Me, R 9 COOC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 31: n is 0, X is S, Y is O, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 32: n is 0, X is S, Y is O, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 33: n is 0, X is S, Y is O, R 6 For Me, R 9 CN, R2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 34: n is 0, X is S, Y is O, R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 35: n is 0, X is S, Y is O, R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 36: n is 0, X is S, Y is O, R 6 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 37: n is 0, X is S, Y is O, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 38: n is 0, X is S, Y is O, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11All are H; Compound 39: n is 0, X is S, Y is O, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 40: n is 0, X is S, Y is O, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 874: n is 0, X is S, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 875: n is 0, X is S, Y is O, R 6 For Me, R 8 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 876: n is 0, X is S, Y is O, R 6 For Me, R 9 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 877: n is 0, X is S, Y is O, R 6 For Me, R 7 Ph, R 2 、R 3 、R4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 878: n is 0, X is S, Y is O, R 6 For Me, R 8 Ph, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 879: n is 0, X is S, Y is O, R 6 For Me, R 9 Ph, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 880: n is 0, X is S, Y is O, R 6 For Me, R 7 Bn, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 881: n is 0, X is S, Y is O, R 6 For Me, R 8 Bn, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 882: n is 0, X is S, Y is O, R 6 For Me, R 9 Bn, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 41: n is 0, X is S, Y is O, R6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 42: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 43: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 44: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 45: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 46: n is 0, X is S, Y is O, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R8 、R 10 、R 11 All are H; Compound 47: n is 0, X is S, Y is O, R 6 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 48: n is 0, X is S, Y is O, R 6 、R 7 、R 9 is the average Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 49: n is 0, X is S, Y is O, R 6 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 50: n is 0, X is S, Y is O, R 6 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 51: n is 0, X is S, Y is O, R 6 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 52: n is 0, X is S, Y is O, R 6 、R 7 、R 9 、R 11Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 53: n is 0, X is S, Y is O, R 6 For Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 54: n is 0, X is S, Y is O, R 6 For Me, R 8 、R 10 For CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 55: n is 0, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 56: n is 0, X is S, Y is O, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 57: n is 0, X is S, Y is O, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11All are H; Compound 58: n is 0, X is S, Y is O, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 59: n is 0, X is S, Y is O, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 60: n is 0, X is S, Y is O, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 61: n is 0, X is S, Y is O, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 62: n is 0, X is S, Y is O, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 63: n is 0, X is S, Y is O, R 6 For Me, R 7 for R 2 、R3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 64: n is 0, X is S, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 65: n is 0, X is S, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 66: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 67: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 68: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R7 、R 10 、R 11 All are H; Compound 69: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 70: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 71: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 is H; Compound 72: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 73: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11All are H; Compound 74: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 75: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 76: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 77: n is 0, X is S, Y is O, R 5 For Me, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 78: n is 0, X is S, Y is O, R 5 For Me, R 7 F, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 79: n is 0, X is S, Y is O, R 5 For Me, R 8 F, R 2 、R3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 80: n is 0, X is S, Y is O, R 5 For Me, R 9 F, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 81: n is 0, X is S, Y is O, R 5 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 82: n is 0, X is S, Y is O, R 5 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 83: n is 0, X is S, Y is O, R 5 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 84: n is 0, X is S, Y is O, R 5 For Me, R 7 Br, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11All are H; Compound 85: n is 0, X is S, Y is O, R 5 For Me, R 8 Br, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 86: n is 0, X is S, Y is O, R 5 For Me, R 9 Br, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 87: n is 0, X is S, Y is O, R 5 For Me, R 7 I, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 88: n is 0, X is S, Y is O, R 5 For Me, R 8 I, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 89: n is 0, X is S, Y is O, R 5 For Me, R 9 I, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 90: n is 0, X is S, Y is O, R 5 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 6、R 8 、R 9 、R 10 、R 11 All are H; Compound 91: n is 0, X is S, Y is O, R 5 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 92: n is 0, X is S, Y is O, R 5 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 93: n is 0, X is S, Y is O, R 5 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 94: n is 0, X is S, Y is O, R 5 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 95: n is 0, X is S, Y is O, R 5 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 96: n is 0, X is S, Y is O, R 5 For Me, R7 For OCF3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 97: n is 0, X is S, Y is O, R 5 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 98: n is 0, X is S, Y is O, R 5 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 99: n is 0, X is S, Y is O, R 5 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 100: n is 0, X is S, Y is O, R 5 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 101: n is 0, X is S, Y is O, R 5 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 6 、R 7 、R8 、R 10 、R 11 All are H; Compound 102: n is 0, X is S, Y is O, R 5 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 103: n is 0, X is S, Y is O, R 5 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 104: n is 0, X is S, Y is O, R 5 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 105: n is 0, X is S, Y is O, R 5 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 106: n is 0, X is S, Y is O, R 5 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 6 、R 8 、R 7 、R 10 、R 11 All are H; Compound 107: n is 0, X is S, Y is O, R 5 For Me, R 7CN, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 108: n is 0, X is S, Y is O, R 5 For Me, R 8 CN, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 109: n is 0, X is S, Y is O, R 5 For Me, R 9 CN, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 110: n is 0, X is S, Y is O, R 5 and R 7 For Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 111: n is 0, X is S, Y is O, R 5 and R 8 For Me, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 112: n is 0, X is S, Y is O, R 5 and R 9 For Me, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R11 All are H; Compound 113: n is 0, X is S, Y is O, R 5 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 114: n is 0, X is S, Y is O, R 5 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 115: n is 0, X is S, Y is O, R 5 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 116: n is 0, X is S, Y is O, R 5 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 117: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 118: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 9 All are Cl, R2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 All are H; Compound 119: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 11 All are H; Compound 120: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 All are H; Compound 121: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 122: n is 0, X is S, Y is O, R 5 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 All are H; Compound 123: n is 0, X is S, Y is O, R 5 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11All are H; Compound 124: n is 0, X is S, Y is O, R 5 、R 7 、R 9 is the average Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 All are H; Compound 125: n is 0, X is S, Y is O, R 5 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 11 All are H; Compound 126: n is 0, X is S, Y is O, R 5 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 All are H; Compound 127: n is 0, X is S, Y is O, R 5 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 6 、R 9 、R 10 All are H; Compound 128: n is 0, X is S, Y is O, R 5 、R 7 、R 9 、R 11 Both Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 All are H; Compound 129: n is 0, X is S, Y is O, R 5 For Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4、R 6 、R 8 、R 10 、R 11 All are H; Compound 130: n is 0, X is S, Y is O, R 5 For Me, R 8 、R 10 For CF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 11 All are H; Compound 131: n is 0, X is S, Y is O, R 5 For Me, R 2 、R 3 、R 4 、R 6 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 132: n is 0, X is S, Y is O, R 5 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 133: n is 0, X is S, Y is O, R 5 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 134: n is 0, X is S, Y is O, R 5 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 135: n is 0, X is S, Y is O, R 5For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 136: n is 0, X is S, Y is O, R 5 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 137: n is 0, X is S, Y is O, R 5 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 138: n is 0, X is S, Y is O, R 5 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 139: n is 0, X is S, Y is O, R 5 For Me, R 7 for R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 140: n is 0, X is S, Y is O, R 5 For Me, R 7 for R 2 、R 3 、R 4、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 141: n is 0, X is S, Y is O, R 5 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 142: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 143: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 144: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 145: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R10 、R 11 All are H; Compound 146: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 147: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 148: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 149: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 150: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11All are H; Compound 151: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 152: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 153: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 2 、R 3 、R 4 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 154: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 F, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 155: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 F, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 156: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 F, R2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 157: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 Cl, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 158: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 Cl, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 159: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 Cl, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 160: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 Br, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 161: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 Br, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11All are H; Compound 162: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 Br, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 163: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 I, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 164: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 I, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 165: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 I, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 166: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 NO2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 167: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 NO2, R 2 、R 3 、R4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 168: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 NO2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 169: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CF3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 170: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 CF3, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 171: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 CF3, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 172: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 173: n is 0, X is S, Y is O, R5 、R 6 Both Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 174: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 175: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 176: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 177: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 178: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For SCF3, R 2 、R 3 、R 4、R 7 、R 8 、R 10 、R 11 All are H; Compound 179: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 180: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 181: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 182: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 8 、R 7 、R 10 、R 11 All are H; Compound 183: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CN, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 184: n is 0, X is S, Y is O, R 5、R 6 Both Me, R 8 CN, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 185: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 CN, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 186: n is 0, X is S, Y is O, R 5 、R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 187: n is 0, X is S, Y is O, R 5 、R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 188: n is 0, X is S, Y is O, R 5 、R 6 and R 9 For Me, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 189: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 8 、R 9 、R10 、R 11 All are H; Compound 190: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 191: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 192: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 193: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 194: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 8 、R 10 、R 11 All are H; Compound 195: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 8 、R 9 、R 11 All are H; Compound 196: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 All are H; Compound 197: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 198: n is 0, X is S, Y is O, R 5 、R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 8 、R 10 、R 11 All are H; Compound 199: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 200: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 9 is the average Me, R 2 、R 3 、R 4 、R 8 、R 10 、R11 All are H; Compound 201: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 8 、R 9 、R 11 All are H; Compound 202: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 All are H; Compound 203: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 9 、R 10 All are H; Compound 204: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 9 、R 11 Both Me, R 2 、 R 3 、R 4 、R 8 、R 10 All are H; Compound 205: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4 、R 8 、R 10 、R 11 All are H; Compound 206: 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 、R 10 For CF3, R 2 、R3 、R 4 、R 7 、R 9 、R 11 All are H; Compound 207: 0, X is S, Y is O, R 5 、R 6 Both Me, R 2 、R 3 、R 4 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 208: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 209: 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 210: 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 211: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 212: 0, X is S, Y is O, R5 、R 6 Both Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 213: 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 214: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 215: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 216: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 for R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 217: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 for R 2 、R3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 218: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 219: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 220: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 221: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 222: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R9 、R 10 、R 11 All are H; Compound 223: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 224: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 225: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 226: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 227: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R11 All are H; Compound 228: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 229: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 230: n is 0, X is S, Y is CH2, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 231: n is 0, X is S, Y is CH2, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 232: n is 0, X is S, Y is CH2, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 233: n is 0, X is S, Y is CH2, R 6 For Me, R 9 F, R2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 234: n is 0, X is S, Y is CH2, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 235: n is 0, X is S, Y is CH2, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 236: n is 0, X is S, Y is CH2, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 237: n is 0, X is S, Y is CH2, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 238: n is 0, X is S, Y is CH2, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10、R 11 All are H; Compound 239: n is 0, X is S, Y is CH2, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 240: n is 0, X is S, Y is CH2, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 241: n is 0, X is S, Y is CH2, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 242: n is 0, X is S, Y is CH2, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 243: n is 0, X is S, Y is CH2, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 244: n is 0, X is S, Y is CH2, R 6 For Me, R 8 NO2, R 2 、R3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 245: n is 0, X is S, Y is CH2, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 246: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 247: n is 0, X is S, Y is CH2, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 248: n is 0, X is S, Y is CH2, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 249: n is 0, X is S, Y is CH2, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R11 All are H; Compound 250: n is 0, X is S, Y is CH2, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 251: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 252: n is 0, X is S, Y is CH2, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 253: n is 0, X is S, Y is CH2, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 254: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 255: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For SCF3, R 2、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 256: n is 0, X is S, Y is CH2, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 257: n is 0, X is S, Y is CH2, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 258: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 259: n is 0, X is S, Y is CH2, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 260: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R11 All are H; Compound 261: n is 0, X is S, Y is CH2, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 262: n is 0, X is S, Y is CH2, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 263: n is 0, X is S, Y is CH2, R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 264: n is 0, X is S, Y is CH2, R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 265: n is 0, X is S, Y is CH2, R 6 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 266: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 267: n is 0, X is S, Y is CH2, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 268: n is 0, X is S, Y is CH2, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 269: n is 0, X is S, Y is CH2, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 270: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 271: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11All are H; Compound 272: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 273: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 274: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、 R 11 All are H; Compound 275: n is 0, X is S, Y is CH2, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 276: n is 0, X is S, Y is CH2, R 6 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 277: n is 0, X is S, Y is CH2, R 6 、R 7 、R 9 is the average Me, R 2 、R3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 278: n is 0, X is S, Y is CH2, R 6 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 279: n is 0, X is S, Y is CH2, R 6 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 280: n is 0, X is S, Y is CH2, R 6 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 281: n is 0, X is S, Y is CH2, R 6 、R 7 、R 9 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 282: n is 0, X is S, Y is CH2, R 6 For Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11All are H; Compound 283: n is 0, X is S, Y is CH2, R 6 For Me, R 8 、R 10 For CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 284: n is 0, X is S, Y is CH2, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 285: n is 0, X is S, Y is CH2, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 286: n is 0, X is S, Y is CH2, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 287: n is 0, X is S, Y is CH2, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 288: n is 0, X is S, Y is CH2, R 6 For Me, R 7 is CH(CH3)2, R 2 、R3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 289: n is 0, X is S, Y is CH2, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 290: n is 0, X is S, Y is CH2, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 291: n is 0, X is S, Y is CH2, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 292: n is 0, X is S, Y is CH2, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 293: n is 0, X is S, Y is CH2, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R9 、R 10 、R 11 All are H; Compound 294: n is 0, X is S, Y is CH2, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 295: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 296: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 297: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 298: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11All are H; Compound 299: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 300: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 300: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 301: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 302: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 303: n is 0, X is S, Y is CH2, R6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 304: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 305: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 306: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 307: n is 0, X is S, Y is NMe, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 308: n is 0, X is S, Y is NMe, R 6 For Me, R 7 F, R 2、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 309: n is 0, X is S, Y is NMe, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 310: n is 0, X is S, Y is NMe, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 311: n is 0, X is S, Y is NMe, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 312: n is 0, X is S, Y is NMe, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 313: n is 0, X is S, Y is NMe, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11All are H; Compound 314: n is 0, X is S, Y is NMe, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 315: n is 0, X is S, Y is NMe, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 316: n is 0, X is S, Y is NMe, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 317: n is 0, X is S, Y is NMe, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 318: n is 0, X is S, Y is NMe, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 319: n is 0, X is S, Y is NMe, R 6 For Me, R 9 I, R 2 、R 3 、R 4、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 320: n is 0, X is S, Y is NMe, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 321: n is 0, X is S, Y is NMe, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 322: n is 0, X is S, Y is NMe, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 323: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 324: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11All are H; Compound 325: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 326: n is 0, X is S, Y is NMe, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 327: n is 0, X is S, Y is NMe, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 328: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 329: n is 0, X is S, Y is NMe, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 330: n is 0, X is S, Y is NMe, R 6 For Me, R 8 For OCHF2, R 2 、R 3、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 331: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 332: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 333: n is 0, X is S, Y is NMe, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 334: n is 0, X is S, Y is NMe, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 335: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11All are H; Compound 336: n is 0, X is S, Y is NMe, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 337: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 338: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 339: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 340: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CH3, R 2 、R 3 、R 4 、 R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 341: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CH3, R 2 、R 3 、R4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 342: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 343: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 344: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 345: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 346: n is 0, X is S, Y is NMe, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R11 All are H; Compound 347: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 348: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 349: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 350: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 351: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 352: n is 0, X is S, Y is NMe, R 6 and R 7 For Me, R 9 Cl, R2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 353: n is 0, X is S, Y is NMe, R 6 、R 7 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 354: n is 0, X is S, Y is NMe, R 6 、R 7 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 355: n is 0, X is S, Y is NMe, R 6 、R 7 and R 10 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 356: n is 0, X is S, Y is NMe, R 6 、R 7 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 357: n is 0, X is S, Y is NMe, R 6 、R 7 、R 8 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10All are H; Compound 358: n is 0, X is S, Y is NMe, R 6 、R 7 、R 9 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 359: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 9 All are CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 360: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 10 All are CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 361: n is 0, X is S, Y is NMe, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 362: n is 0, X is S, Y is NMe, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 363: n is 0, X is S, Y is NMe, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 364: n is 0, X is S, Y is NMe, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 365: n is 0, X is S, Y is NMe, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 366: n is 0, X is S, Y is NMe, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 367: n is 0, X is S, Y is NMe, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 368: n is 0, X is S, Y is NMe, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10、R 11 All are H; Compound 369: n is 0, X is S, Y is NMe, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 370: n is 0, X is S, Y is NMe, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 371: n is 0, X is S, Y is NMe, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 372: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 373: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 374: n is 0, X is S, Y is NMe, R 6For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 375: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、 R 11 All are H; Compound 376: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 377: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 378: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 379: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 380: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 381: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 382: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 383: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 873: n is 0, X is S, Y is NH, R 6 For Me, R 2 、R 3 、R 4 、R5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 883: n is 0, X is S, Y is S, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 384: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 385: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 386: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 F, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 387: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 F, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 388: n is 0, X is S, Y is O, R2 、R 6 For Me, R 7 Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 389: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 Cl, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 390: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 391: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 Br, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 392: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 Br, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 393: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 Br, R 3 、R 4 、R 5 、R 7 、R8 、R 10 、R 11 All are H; Compound 394: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 I, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 395: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 I, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 396: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 I, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 397: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 NO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 398: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 NO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 399: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9NO2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 400: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 401: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 402: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 403: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 For OCF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 404: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 For OCF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R11 All are H; Compound 405: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For OCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 406: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 For OCHF2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 407: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 408: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 409: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For SCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 410: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 For OCH3, R3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 411: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 For OCH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 412: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For OCH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 413: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 OC2H5, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 414: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CN, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 415: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CN, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11All are H; Compound 416: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CN, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 417: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 418: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 419: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 420: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CH3SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 421: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CH3SO2, R 3 、R4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 422: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 423: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 C2H5SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 424: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 All are Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 425: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 9 All are Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 426: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 10 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 11All are H; Compound 427: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 11 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 428: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 All are Cl, R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 429: n is 0, X is S, Y is O, R 2 、R 6 and R 7 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 430: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 8 For Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 431: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 9 For Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 432: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 10 For Me, R 3 、R 4、R 5 、R 8 、R 9 、R 11 All are H; Compound 433: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 434: n is 0, X is S, Y is O, R 2 、R 6 、R 7 、R 8 and R 11 For Me, R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 435: n is 0, X is S, Y is O, R 2 、R 6 、R 7 、R 9 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 436: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 9 All are CF3, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 437: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 10 All are CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 438: n is 0, X is S, Y is O, R 2 、R 6For Me, R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 439: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 is CH3CH2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 440: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 441: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 442: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 is CH(CH3)2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 443: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R9 、R 10 、R 11 All are H; Compound 444: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 445: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 446: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 C(CH3)3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 447: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 448: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 for R 3 、R 4 、 R 5 、R 8 、R 9 、R 10 、R 11All are H; Compound 449: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CO2CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 450: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 451: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 452: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 453: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 454: n is 0, X is S, Y is O, R 2 、R 6For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 455: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 456: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 457: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 458: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 459: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 460: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 461: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 462: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 463: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 F, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 464: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 F, R 3 、R 4 、R 5 、R 7 、R 8 、R10 、R 11 All are H; Compound 465: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 466: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 Cl, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 467: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 468: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 Br, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 469: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 Br, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 470: n is 0, X is S, Y is O, R 2 For C2H5, R 6For Me, R 9 Br, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 471: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 I, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 472: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 I, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 473: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 I, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 474: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 NO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 475: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 NO2, R 3 、R 4 、R 5 、R 7 、R9 、R 10 、R 11 All are H; Compound 476: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 NO2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 477: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 478: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 479: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 480: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 For OCF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 481: n is 0, X is S, Y is O, R 2For C2H5, R 6 For Me, R 8 For OCF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 482: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For OCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 483: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 For OCHF2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 484: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 485: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 486: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For SCF3, R 3 、R 4、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 487: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 For OCH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 488: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 For OCH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 489: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For OCH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 490: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 OC2H5, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 491: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CN, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11All are H; Compound 492: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CN, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 493: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CN, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 494: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 495: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 496: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 497: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7CH3SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 498: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 499: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 500: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 C2H5SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 501: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 All are Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 502: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 9 All are Cl, R 3 、R 4 、R 5 、R8 、R 10 、R 11 All are H; Compound 503: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 10 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 504: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 11 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 505: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 All are Cl, R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 506: n is 0, X is S, Y is O, R 2 For C2H5, R 6 and R 7 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 507: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 and R 8 For Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 508: n is 0, X is S, Y is O, R 2 For C2H5, R6 、R 7 and R 9 For Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 509: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 and R 10 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 510: n is 0, X is S, Y is O, R 2 For C2H5, R 7 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 511: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 、R 8 and R 11 For Me, R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 512: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 、R 9 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 513: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 9 All are CF3, R 3 、R 4 、R 5 、R 8 、R10 、R 11 All are H; Compound 514: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 10 All are CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 515: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 516: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 is CH3CH2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 517: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 518: n is 0, X is S, Y is O, R 2 is C2H5, R 6 For Me, R 9 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 519: n is 0, X is S, Y is O, R 2 For C2H5, R6 For Me, R 7 is CH(CH3)2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 520: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 521: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 522: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 523: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 C(CH3)3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 524: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 525: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 526: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CO2CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 527: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 528: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 529: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 530: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 531: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 532: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 533: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 534: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4、R 5 、R 9 、R 10 、R 11 All are H; Compound 535: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 536: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 537: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 796: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 797: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R11 All are H; Compound 798: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 F, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 799: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 F, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 800: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 801: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 Cl, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 802: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 803: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 Br, R3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 804: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 Br, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 805: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 Br, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 806: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 I, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 807: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 I, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 808: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 I, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R11 All are H; Compound 809: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 NO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 810: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 NO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 811: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 NO2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 812: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 813: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 814: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9CF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 815: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 For OCF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 816: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 For OCF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 817: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For OCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 818: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 For OCHF2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 819: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 9、R 10 、R 11 All are H; Compound 820: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 821: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For SCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 822: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 For OCH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 823: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 For OCH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 824: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For OCH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 825: n is 0, X is S, Y is O, R 2 OMe, R6 For Me, R 9 OC2H5, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 826: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CN, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 827: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CN, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 828: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 CN, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 829: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 830: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CH3, R 3 、R 4 、R 5 、R7 、R 9 、R 10 、R 11 All are H; Compound 831: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 CH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 832: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CH3SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 833: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 834: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 835: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 C2H5SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11All are H; Compound 836: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 All are Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 837: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 9 All are Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 838: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 10 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 839: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 11 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 840: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 All are Cl, R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 841: n is 0, X is S, Y is O, R 2 OMe, R 6 and R 7 For Me, R9 Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 842: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 and R 8 For Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 843: n is 0, X is S, Y is O, R 2 OMe, R 6 、 R 7 and R 9 For Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 844: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 and R 10 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 845: n is 0, X is S, Y is O, R 2 OMe, R 7 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 846: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 、R 8 and R 11 For Me, R 3 、R 4 、R 5 、R 9 、R 10All are H; Compound 847: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 、R 9 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 848: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 9 All are CF3, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 849: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 10 All are CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 850: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 851: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 is CH3CH2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 852: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 is CH3CH2, R3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 853: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 854: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 is CH(CH3)2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 855: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 856: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 857: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R8 、R 9 、R 10 、R 11 All are H; Compound 858: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 C(CH3)3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 859: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 860: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 861: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CO2CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 862: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R11 All are H; Compound 863: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 864: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 865: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 866: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 867: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11All are H; Compound 868: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 869: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 870: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 871: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 872: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11All are H; Compound 538: n is 0, X is SO, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 539: n is 0, X is SO, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 540: n is 0, X is SO, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 541: n is 0, X is SO, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 542: n is 0, X is SO, Y is O, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 543: n is 0, X is SO, Y is O, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 544: n is 0, X is SO, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 545: n is 0, X is SO, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 546: n is 0, X is SO, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 547: n is 0, X is SO, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 548: n is 0, X is SO, Y is O, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 549: n is 0, X is SO, Y is O, R 6For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 550: n is 0, X is SO, Y is O, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 551: n is 0, X is SO, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 552: n is 0, X is SO, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 553: n is 0, X is SO, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 554: n is 0, X is SO, Y is O, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R9 、R 10 、R 11 All are H; Compound 555: n is 0, X is SO, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 556: n is 0, X is SO, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 557: n is 0, X is SO, Y is O, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 558: n is 0, X is SO, Y is O, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 559: n is 0, X is SO, Y is O, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 560: n is 0, X is SO, Y is O, R 6 For Me, R 7For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 561: n is 0, X is SO, Y is O, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 562: n is 0, X is SO, Y is O, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 563: n is 0, X is SO, Y is O, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 564: n is 0, X is SO, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 565: n is 0, X is SO, Y is O, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9、R 10 、R 11 All are H; Compound 566: n is 0, X is SO, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 567: n is 0, X is SO, Y is O, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 568: n is 0, X is SO, Y is O, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 569: n is 0, X is SO, Y is O, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 570: n is 0, X is SO, Y is O, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 571: n is 0, X is SO, Y is O, R 6 For Me, R 7 CH3, R2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 572: n is 0, X is SO, Y is O, R 6 For Me, R 8 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 573: n is 0, X is SO, Y is O, R 6 For Me, R 9 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 574: n is 0, X is SO, Y is O, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 575: n is 0, X is SO, Y is O, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 576: n is 0, X is SO, Y is O, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R10 、R 11 All are H; Compound 577: n is 0, X is SO, Y is O, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 578: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 579: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 580: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 581: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 582: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 583: n is 0, X is SO, Y is O, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 584: n is 0, X is SO, Y is O, R 6 、R 7 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 585: n is 0, X is SO, Y is O, R 6 、R 7 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 586: n is 0, X is SO, Y is O, R 6 、R 7 and R 10 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 587: n is 0, X is SO, Y is O, R 6 、R 7 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10All are H; Compound 588: n is 0, X is SO, Y is O, R 6 、R 7 、R 8 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 589: n is 0, X is SO, Y is O, R 6 、R 7 、R 9 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 590: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 9 All are CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 591: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 10 All are CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 592: n is 0, X is SO, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 593: n is 0, X is SO, Y is O, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 594: n is 0, X is SO, Y is O, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 595: n is 0, X is SO, Y is O, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 596: n is 0, X is SO, Y is O, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 597: n is 0, X is SO, Y is O, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 598: n is 0, X is SO, Y is O, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11All are H; Compound 599: n is 0, X is SO, Y is O, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 600: n is 0, X is SO, Y is O, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 601: n is 0, X is SO, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 602: n is 0, X is SO, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 603: n is 0, X is SO, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 604: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 605: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 606: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 607: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 608: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 609: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 610: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 611: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 612: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 613: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 614: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 615: n is 0, X is SO2, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 616: n is 0, X is SO2, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 617: n is 0, X is SO2, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 618: n is 0, X is SO2, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 619: n is 0, X is SO2, Y is O, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 620: n is 0, X is SO2, Y is O, R6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 621: n is 0, X is SO2, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 622: n is 0, X is SO2, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 623: n is 0, X is SO2, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 624: n is 0, X is SO2, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 625: n is 0, X is SO2, Y is O, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R8 、R 9 、R 10 、R 11 All are H; Compound 626: n is 0, X is SO2, Y is O, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 627: n is 0, X is SO2, Y is O, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 628: n is 0, X is SO2, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 629: n is 0, X is SO2, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 630: n is 0, X is SO2, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 631: n is 0, X is SO2, Y is O, R 6 For Me, R7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 632: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 633: n is 0, X is SO2, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 634: n is 0, X is SO2, Y is O, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 635: n is 0, X is SO2, Y is O, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 636: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R8 、R 10 、R 11 All are H; Compound 637: n is 0, X is SO2, Y is O, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 638: n is 0, X is SO2, Y is O, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 639: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 640: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 641: n is 0, X is SO2, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 642: n is 0, X is SO2, Y is O, R 6 For Me, R8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 643: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 644: n is 0, X is SO2, Y is O, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 645: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 646: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 647: n is 0, X is SO2, Y is O, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R8 、R 10 、R 11 All are H; Compound 648: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 649: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 650: n is 0, X is SO2, Y is O, R 6 For Me, R 9 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 651: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 652: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 653: n is 0, X is SO2, Y is O, R 6 For Me, R9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 654: n is 0, X is SO2, Y is O, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 655: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 656: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 657: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 658: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5、R 8 、R 9 、R 10 All are H; Compound 659: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 660: n is 0, X is SO2, Y is O, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 661: n is 0, X is SO2, Y is O, R 6 、R 7 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 662: n is 0, X is SO2, Y is O, R 6 、R 7 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 663: n is 0, X is SO2, Y is O, R 6 、R 7 and R 10 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 664: n is 0, X is SO2, Y is O, R 6 、R 7 and R11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 665: n is 0, X is SO2, Y is O, R 6 、R 7 、R 8 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 666: n is 0, X is SO2, Y is O, R 6 、R 7 、R 9 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 667: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 9 All are CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 668: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 10 All are CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 669: n is 0, X is SO2, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10、R 11 All are F; Compound 670: n is 0, X is SO2, Y is O, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 671: n is 0, X is SO2, Y is O, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 672: n is 0, X is SO2, Y is O, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 673: n is 0, X is SO2, Y is O, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 674: n is 0, X is SO2, Y is O, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 675: n is 0, X is SO2, Y is O, R 6 For Me, R 9is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 676: n is 0, X is SO2, Y is O, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 677: n is 0, X is SO2, Y is O, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 678: n is 0, X is SO2, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 679: n is 0, X is SO2, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 680: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 681: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 682: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 683: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 684: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 685: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R7 、R 10 、R 11 All are H; Compound 686: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 687: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 688: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 689: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 690: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R11 All are H; Compound 691: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 692: n is 1, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 693: n is 2, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 697: n is 0, X is S, Y is O, R 2 for R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 Both H, R 6 For CH3.

[0055] According to another preferred embodiment, in formula (I), R 1 Selected from C 1-6 Alkyl, -(CH2) z -phenyl, an unsaturated five-membered ring group containing a B-type heteroatom, a saturated four-membered ring group containing a B-type heteroatom, an unsaturated six-membered ring group containing a B-type heteroatom, C 4-8 saturated cycloalkyl, benzothiazolyl, benzoxazolyl, benzopyrazolyl, benzothienyl, N-methyl-benzopyrrolyl, z is an integer of 1, 2, 3, 4, 5 or 6; each of the B-type heteroatoms is independently selected from at least one of O, S, and N; and optionally, the B-type heteroatoms contain C 1-3 An alkyl group as a substituent; R 2 is selected from H, n-butyl, -CH2-phenyl; R 3 、R 4 and R 5 Both H; R 6 is methyl; n is 0; X is S; and Y is O.

[0056] More preferably, in formula (I), n, X, Y, R 1 、R 2 、R 3 、R 4 、R 5 、R 6 The replacement is as follows:

[0057] Compound 694: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 695: n is 0, X is S, Y is O, R 1 for R 2 H, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 696: n is 0, X is S, Y is O, R 1 for R 2 for R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 698: n is 0, X is S, Y is O, R 1 CH3, R 2 CH3, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 699: n is 0, X is S, Y is O, R 1 is CH3CH2, R 2 CH3, R 3 、R 4 、R 5 Both H, R6 is CH3; Compound 700: n is 0, X is S, Y is O, R 1 is CH3CH2, R 2 is CH3CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 701: n is 0, X is S, Y is O, R 1 (CH3)2CH2, R 2 (CH3)2CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 702: n is 0, X is S, Y is O, R 1 (CH3)2CH2, R 2 is CH3CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 703: n is 0, X is S, Y is O, R 1 is CH3CH3CH2, R 2 is CH3CH3CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 704: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 705: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 706: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 707: n is 0, X is S, Y is O, R 1 for R2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 708: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 709: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 710: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 711: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 712: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 713: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 714: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6is CH3; Compound 715: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 716: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 717: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 718: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 719: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 720: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 721: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 722: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R4 、R 5 Both H, R 6 is CH3; Compound 723: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 724: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 725: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 726: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 727: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 728: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 729: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 730: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 731: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 732: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 733: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 734: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 735: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 736: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 737: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6is CH3; Compound 738: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 739: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 740: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 741: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 742: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 743: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 744: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 745: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R4 、R 5 Both H, R 6 is CH3; Compound 746: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 747: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 748: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 749: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 750: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 751: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 752: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 753: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 754: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 755: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 756: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 757: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 758: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 759: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 760: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6is CH3; Compound 761: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 762: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 763: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 764: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 765: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 766: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 767: n is 0, X is S, Y is O, R 1 is CH3(CH2)3, R 2 is CH3(CH2)3, R 3 、R 4 、R 5 Both H, R 6 For CH3.

[0058] Preferably, in formula (1), X and Y are both O. More preferably, the compound represented by formula (I) has the structure of the compound represented by formula (IA): Wherein, in formula (IA), n, X, Y, R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 The replacement is as follows:

[0059] Compound 768: n is 0, X is O, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 769: n is 0, X is O, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 770: n is 0, X is O, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 771: n is 0, X is O, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 772: n is 0, X is O, Y is O, R 6 For Me, R 7 Cl, R 2 、R 3、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 773: n is 0, X is O, Y is O, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 774: n is 0, X is O, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 775: n is 0, X is O, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 776: n is 0, X is O, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 777: n is 0, X is O, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11All are H; Compound 778: n is 0, X is O, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 779: n is 0, X is O, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 780: n is 0, X is O, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 781: n is 0, X is O, Y is O, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 782: n is 0, X is O, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 783: n is 0, X is O, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 784: n is 0, X is O, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 785: n is 0, X is O, Y is O, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 786: n is 0, X is O, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 787: n is 0, X is O, Y is O, R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 788: n is 0, X is O, Y is O, R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 789: n is 0, X is O, Y is O, R 6 and R9 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 790: n is 0, X is O, Y is O, R 5 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 791: n is 0, X is O, Y is O, R 5 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 792: n is 0, X is O, Y is O, R 5 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 793: n is 0, X is O, Y is O, R 5 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 794: n is 0, X is O, Y is O, R 5 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7、R 9 、R 10 、R 11 All are H; Compound 795: n is 0, X is O, Y is O, R 5 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 Both are H.

[0060] In the present invention, there is no particular limitation on the stereostructure of the compound represented by formula (I). The compound represented by formula (I) may exist in the form of different stereoisomers, optical isomers, or tautomers. The present invention includes all stereoisomers, optical isomers, or tautomers and mixtures thereof in various proportions.

[0061] The present invention does not particularly limit the specific method for preparing the amide compounds described in the first aspect. Those skilled in the art can obtain the aforementioned compounds of the present invention based on the specific structural formula provided by the present invention in combination with known process routes in the field of organic synthesis. In addition, several examples are exemplified in the following text of the present invention to illustrate the preparation method of the compounds of the present invention. Those skilled in the art can also obtain the specific preparation method of all other compounds by replacing the type of raw materials according to the preparation method of the compounds in the following text of the present invention. The present invention no longer describes the preparation method of all compounds in detail, and those skilled in the art should not understand it as limiting the present invention.

[0062] Preferably, in order to obtain the compound having the structure represented by formula (I) according to the present invention in a higher yield, the present invention provides a method as described in the second aspect for preparing the amide compound as described in the first aspect, the method comprising: contacting and reacting the compound represented by formula (V-1) with the compound represented by formula (V-2);

[0063] Wherein, the substitution of the substituents in formula (V-1) and formula (V-2) corresponds to the same substitution in the amide compounds described in the first aspect, and one of Z1 and Z2 is -Br and the other is -XH, and the definition of X corresponds to the same definition in the amide compounds described in the first aspect.

[0064] The present invention has no particular requirements for the specific operating conditions of the contact reaction. Those skilled in the art can determine reasonable ranges or values ​​based on known knowledge in the field of organic synthesis in combination with the preparation methods exemplified herein below. The present invention will not be further described herein, and those skilled in the art should not be construed as limiting the present invention.

[0065] Preferably, in order to obtain the compound having the structure represented by formula (I) of the present invention in a higher yield, the present invention also provides a method as described in the third aspect for preparing the amide compound as described in the first aspect, the method comprising: subjecting the compound represented by formula (II) to a coupling reaction with the compound represented by formula (III);

[0066] The substitution conditions of the substituents in formula (III) and formula (II) are the same as those in the amide compounds described in the first aspect.

[0067] The present invention has no special requirements on the molar ratio of the compound represented by formula (III) to the compound represented by formula (II) and the reaction conditions. Those skilled in the art can determine the appropriate dosage ratio and reaction conditions based on the structural characteristics and the organic synthesis knowledge known in the art.

[0068] The present invention has no particular requirements for the specific operating conditions of the coupling reaction. Those skilled in the art can determine reasonable ranges or values ​​based on the known knowledge in the field of organic synthesis in combination with the preparation methods exemplified herein. The present invention will not be further described herein, and those skilled in the art should not be construed as limiting the present invention.

[0069] More preferably, the method for preparing the compound having the structure of formula (II) comprises: removing the tert-butoxy group in the compound represented by formula (IV) in the presence of an acidic substance and a solvent;

[0070] Wherein, in formula (IV),

[0071] n, X, Y, R 3 、R 4 、R 5 、R 6 The definitions of are the same as those described above in the present invention.

[0072] The present invention has no special requirements on the reaction conditions for removing the tert-butoxy group from the compound represented by formula (IV). Those skilled in the art can determine appropriate reaction conditions based on the structural characteristics and the organic synthesis knowledge known in the art.

[0073] It should be understood by those skilled in the art that the method described in the present invention may further include a step of purifying the obtained product. There are no particular requirements for the purification method, and various purification methods conventionally used by those skilled in the art may be adopted, for example, filtration, solvent removal, extraction with an extractant, drying with a desiccant, and impurity removal by column chromatography and the like.

[0074] The fourth aspect of the present invention provides the use of the amide compound described in the first aspect in agronomy.

[0075] Preferably, the application in agronomy is selected from at least one of increasing crop yield, managing abiotic stress on plants, regulating plant growth, enhancing plant disease resistance, and promoting seed germination.

[0076] Preferably, the seeds are selected from at least one of wheat, soybean, barley, corn, rice, sorghum, Solanaceae, barnyard grass, peanut and other legumes, crabgrass, and foxtail grass.

[0077] The amide compounds in the present invention may exist alone in the application described in the second aspect, or may exist as active ingredients in powders, solutions, etc., which should not be construed as limiting the present invention by those skilled in the art.

[0078] A fifth aspect of the present invention provides a biostimulant, which contains an effective amount of plant growth regulating at least one of the amide compounds described in the first aspect, and optionally contains an auxiliary material.

[0079] Preferably, the biostimulant is applied to plants to increase the biomass or yield of the plants by regulating the growth and development process of the plants; the plants are selected from at least one of wheat, peanuts, corn, soybeans, and alfalfa.

[0080] The present invention has no particular requirements on the specific types of excipients in the biostimulant. Those skilled in the art can select corresponding excipients known in the art to prepare the biostimulant of the present invention according to the dosage form. The present invention will not be described in detail here, and those skilled in the art should not be construed as limiting the present invention.

[0081] Preferably, in the biostimulant, the content of the amide compound is 1-99.99 wt%, or the content of the amide compound is 0.001 ppm-100 ppm.

[0082] The present invention also provides a method for applying pesticides, which comprises applying an effective amount of the amide compound described in the first aspect and / or the regulator described in the third aspect to an area containing plant propagation materials and / or plant growth.

[0083] It should be noted that the amide compounds of the present invention can be used alone or in combination with plant hormones, such as auxins, gibberellins, cytokinins, ethylene and abscisic acid. Exemplarily, the amide compounds provided by the present invention can be used in combination with brassinolide, polyamines and jasmonic acid, pyraclostrobin, metyltetraprole, chlorpyrifos-methyl, pyraclostrobin, enestrobin, azoxystrobin, fluoxastrobin, trifloxystrobin, syringystrobin, fluoxastrobin, pyraclostrobin, boscalid, benzovinflumizone, pyraclostrobin, fluoxazolidinone, fluopyram, fluopyram, etc., and the combined use can achieve a synergistic effect.

[0084] The present invention also provides a weed control method, comprising: applying a germination-promoting amount of the amide compound of the first aspect and / or the regulator of the third aspect to an area containing weeds to cause "temporal and spatial mismatched germination" of the weeds, and then spraying a herbicide on the weeds after they have emerged.

[0085] In the present invention, the area containing weeds includes agricultural land with root parasitic weeds, and the agricultural land may include but is not limited to rice fields, wheat fields, sunflower fields, carrot fields, tobacco fields, Solanaceae fields, corn fields, peanut and other legume fields or sorghum fields; preferably, the root parasitic weeds are Striga and / or Orobanche; the Striga is selected from at least one of Striga asiatica (L.) O. Kuntze, Striga masuria (Ham. ex Benth.) Benth and Striga densiflora Benth; the Orobanche is selected from at least one of Orobanche minor Sm and Orobanche ramosa L.

[0086] The present invention has no particular requirements for the specific type of the herbicide. Those skilled in the art can select herbicides known in the art. The present invention will not be described in detail here, and those skilled in the art should not interpret this as a limitation of the present invention.

[0087] The present invention will be described in detail below through examples.

[0088] Unless otherwise specified, the room temperature or normal temperature in the following examples refers to 25±3°C.

[0089] Unless otherwise specified, all raw materials used in the following examples were purchased from commercial sources, and the prepared products were characterized by NMR data.

[0090] Unless otherwise specified, the yields in the present invention are calculated based on the main raw materials in the last step of the chemical reaction to obtain the compound.

[0091] Unless otherwise specified, CK stands for blank control.

[0092] Preparation Example 1: Preparation of Compound I-1

[0093] This preparation example is used to illustrate the synthesis of compound I-1.

[0094] 20 mmol of potassium carbonate and 20 mmol of tert-butyl 2-mercaptoacetate were added to a reaction flask, 50 mL of acetone was added under stirring, and the reaction was carried out at room temperature for 15 min. Then, 20 mmol of 5-bromo-3-methylfuran-2(5H)-one was added, and the reaction was continued with stirring for 3 h. Insoluble matter was removed by filtration with the aid of diatomaceous earth, and acetone in the solution was removed under reduced pressure. The intermediate was purified by column chromatography to obtain compound IV-1 with a yield of 65%. The NMR data were: 1 H NMR (400MHz, CDCl3) δ7.00(s,1H),6.15(s,1H),3.43(d,J=15.6Hz,1H),3.19(d,J=15.6Hz,1H),1.96(s,3H),1.47(s,9H);

[0095] 10 mmol of the compound IV-1 was dissolved in 20 mL of dichloromethane solution, 5 mL of trifluoroacetic acid was added, and the mixture was reacted at room temperature for 2 hours. After purification by column chromatography, compound I-1 was obtained with a yield of 90%. The NMR data was 1 H NMR (400MHz, DMSO-d6) δ 12.76 (s, 1H), 7.36 (s, 1H), 6.37 (s, 1H), 3.40 (q, J = 15.6Hz, 2H), 1.84 (s, 3H).

[0096] Preparation Example 2: Preparation of Compound I-2

[0097] This preparation example is used to illustrate the synthesis of compound I-2. The present invention exemplarily provides the following synthesis method to obtain the compound I-2.

[0098] 30 mol of compound I-1 synthesized in Preparation Example 1 was dissolved in 60 mL of dichloromethane, and 30 mmol of methylchloroperbenzoic acid was added under ice bath conditions. After reacting for 4 hours, a saturated sodium bicarbonate solution was added to quench the reaction. The mixture was then extracted with water, and the organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. After vacuum concentration, the compound I-2 was purified by column chromatography with a yield of 60%. The NMR data was1 H NMR (400MHz, DMSO-d6) δ13.48(s,1H),7.53(s,1H),6.24(s,1H),3.81(dd,J=17.6,15.2Hz,2H),1.90(s,3H).

[0099] Preparation Example 3: Preparation of Compound I-3

[0100] Dissolve 21 mmol of aniline and 21 mmol of thioglycolic acid in 20 mL of anhydrous toluene, heat to 110°C, and react for 12 hours. Cool the reaction mixture to room temperature and concentrate in vacuo to obtain an oily product. Column chromatography yields I-3 as a white solid in 80% yield. NMR data: 1 H NMR (400MHz, DMSO-d6) δ10.07(d,J=10.3Hz,1H),7.57(t,J=6.6Hz,2H),7.29(dt ,J=13.3,7.8Hz,2H),7.05(q,J=6.7,6.0Hz,1H),3.39-3.20(m,2H),2.95(s,1H).

[0101] Preparation Example 4: Preparation of Compound I-4

[0102] 20 mmol of aniline was dissolved in 20 mL of dichloromethane, and then 21 mmol of bromoacetyl bromide and 25 mmol of potassium carbonate were added. The mixture was reacted at room temperature for 2 hours. After the reaction was complete, the solid was filtered out and the organic phase was concentrated and subjected to column chromatography to obtain compound I-4. The yield was 85%; the NMR data was 1 H NMR (400MHz, CDCl3) δ9.90 (s, 1H), 7.75-7.49 (m, 2H), 7.40-7.24 (m, 2H), 7.07 (tt, J = 7.2, 2.0Hz, 1H), 4.24 (s, 2H).

[0103] Preparation Example 5: Preparation of Compound I-5

[0104] 10 mmol of 5-hydroxy-3-methylfuran-2(5H)-one was dissolved in 10 mL of toluene solution, and then 5 mmol of Lawesson's reagent was added and heated to reflux for 12 hours. After the reaction was complete, it was quenched with ice water, extracted with ethyl acetate, and the organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. After vacuum concentration, it was purified by column chromatography to obtain compound I-5 with a yield of 36%. The NMR data was 1H NMR (400MHz, DMSO-d6) δ7.41 (dd, J=6.4, 1.2Hz, 1H), 6.07 (dd, J=6.4, 1.2Hz, 1H), 2.02 (s, 3H) 1.40 (s, 1H).

[0105] Preparation Example 6: Preparation of Compound 1

[0106] Compounds I-4 (3 mmol) and I-5 (2.8 mmol) were dissolved in 5 mL of N,N-dimethylformamide, and potassium carbonate (4.5 mmol) was added. The mixture was allowed to react for 3 hours at room temperature. After the reaction was complete, the solid was removed by filtration, and the mixture was extracted with ethyl acetate and water. The organic phase was collected and washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated in vacuo to obtain an oily product. The yield of compound 1 by column chromatography was 25%; the NMR data was 1 H NMR (400MHz, DMSO-d6) δ10.15(s,1H),7.56(d,J=8.0Hz,2H),7.40-7.25(m,3H),7.06(t,J=7.2Hz,1H),6.43(s,1H),3.56-3.43(m,2H),1.82(s,3H).

[0107] Preparation Example 7: Preparation of Compound 1

[0108] Compound 1-3 (13.3 mmol) and 5-bromo-3-methylfuran-2(5H)-one (13.3 mmol) were dissolved in 200 mL of dichloromethane under ice-cooling conditions. 15 mmol of triethylamine was then added, and the mixture was stirred at room temperature for 1 hour. TLC indicated the reaction was complete. The mixture was concentrated in vacuo to obtain an oil, which was purified by column chromatography to obtain compound 1 in a yield of 67%. 1 HNMR (400MHz, DMSO-d6) δ10.15(s,1H),7.56(d,J=8.0Hz,2H),7.40-7.25(m,3H),7.06(t,J=7.2Hz,1H),6.43(s,1H),3.56-3.43(m,2H),1.82(s,3H).

[0109] Preparation Example 8: Preparation of Compound 1

[0110] 1 mmol of compound I-1 synthesized in Preparation Example 1 was dissolved in 5 mL of dichloromethane solution, and then 1.5 mmol of (7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU) and 2 mmol of triethylamine were added. After stirring at room temperature for 15 minutes, 1.1 mmol of aniline was added to the reaction solution. After reacting at room temperature for 6 hours, water was added to the reaction solution for extraction. The organic phase was washed with 1 mol / L hydrochloric acid and saturated brine, respectively, and dried over anhydrous sodium sulfate, concentrated in vacuo, and then purified by column chromatography to obtain the compound 1 in a yield of 50%; the nuclear magnetic resonance data was 1 H NMR (400MHz, DMSO-d6) δ10.15(s,1H),7.56(d,J=8.0Hz,2H),7.40-7.25(m,3H),7.06(t,J=7.2Hz,1H),6.43(s,1H),3.56-3.43(m,2H),1.82(s,3H).

[0111] Preparation Example 9: Preparation of Compound 4

[0112] Under ice bath conditions, 1 mmol of compound I-1 obtained by preparation example 1 was dissolved in 5 mL of dichloromethane solution, and then 1.1 mmol of oxalyl chloride and 0.1 mmol of N,N-dimethylformamide were added. After reacting at room temperature for 2 hours, an oily substance was obtained. The obtained oily substance was dissolved in 5 mL of dichloromethane solution, and then 1 mmol of p-fluoroaniline and 1 mmol of triethylamine were added. After reacting at room temperature for 2 hours, compound 4 was purified by column chromatography with a yield of 63%; the nuclear magnetic resonance data was 1 H NMR (400MHz, CDCl3) δ8.29 (s, 1H), 7.57-7.50 (m, 2H), 7.11-6.98 (m, 3H), 6.15-6.03 (m, 1H), 3.62-3.41 (m, 2H), 1.99 (t, J = 2.0Hz, 3H).

[0113] Preparation Example 10: Preparation of Compound 5

[0114] 1 mmol of compound I-1 synthesized in Preparation Example 1 was dissolved in 5 mL of dichloromethane solution, and then 1.5 mmol of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) and 0.1 mmol of 4-dimethylaminopyridine (DMAP) were added. Then, 1.1 mmol of o-chloroaniline was added to the reaction solution. After reacting at room temperature for 6 hours under argon protection, water was added to the reaction solution for extraction. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. After vacuum concentration, it was purified by column chromatography to obtain compound 5 with a yield of 75%; the nuclear magnetic resonance data was 1 H NMR (400MHz, CDCl3) δ8.80(s,1H),8.32(d,J=8.0Hz,1H),7.39(d,J=9.2Hz,1H),7.29(t,J=8.0Hz,1H),7.0 8(t,J=8.4Hz,1H),7.02(s,1H),6.09(s,1H),3.62(d,J=16.8Hz,1H),3.46(d,J=16.8Hz,1H),1.96(s,3H).

[0115] Preparation Example 11: Preparation of Compound 9

[0116] 1 mmol of compound I-1 synthesized in Preparation Example 1 was dissolved in 5 mL of dichloromethane solution, and then 1.5 mmol of (7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU) and 2 mmol of N-ethyldiisopropylamine (DIPEA) were added. After stirring at room temperature for 15 minutes, 1.1 mmol of m-bromoaniline was added to the reaction solution. After reacting at room temperature for 3 hours, water was added to the reaction solution for extraction. The organic phase was washed with 1 mol / L hydrochloric acid and saturated brine in sequence, and dried over anhydrous sodium sulfate. After vacuum concentration, it was purified by column chromatography to obtain compound 9 with a yield of 71%; the nuclear magnetic resonance data was 1 H NMR (400MHz, CDCl3) δ8.34 (s, 1H), 7.85 (s, 1H), 7.45 (d, J = 8.4Hz, 1H), 7.31-7.26 (m, 1H ), 7.21 (t, J = 8.0Hz, 1H), 7.02 (s, 1H), 6.09 (s, 1H), 3.51 (q, J = 16.8Hz, 2H), 1.99 (s, 3H).

[0117] Preparation Example 12: Preparation of Compound 19

[0118] 1 mmol of compound I-1 synthesized in Preparation Example 1 was dissolved in 5 mL of dichloromethane solution, and then 1.5 mmol of benzotriazole-N,N,N',N'-tetramethyluronium hexafluorophosphate (HBTU) and 2 mmol of N-ethyldiisopropylamine (DIPEA) were added, and stirred at room temperature for 15 minutes. 1.1 mmol of 4-trifluoromethylaniline was added to the reaction solution, and the reaction was continued for 3 hours. Water was added to the reaction solution for extraction, and the organic phase was washed with 1 mol / L hydrochloric acid and saturated brine in sequence, and dried over anhydrous sodium sulfate. After vacuum concentration, it was purified by column chromatography to obtain compound 19 with a yield of 68%; the nuclear magnetic resonance data was 1 H NMR (400MHz, DMSO-d6) δ10.52(s,1H),7.77(d,J=8.4Hz,2H),7.68(d,J=8.4Hz,2H),7.36(s,1H),6.42(s,1H),3.62-3.46(m,2H),1.82(s,3H).

[0119] Preparation Example 13: Preparation of Compound 22

[0120] 1 mmol of compound I-1 synthesized in Preparation Example 1 was dissolved in 5 mL of dichloromethane solution, and then 2 mmol of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) and 2 mmol of 1-hydroxybenzotriazole (HOBT) were added. Then, 1.1 mmol of 4-trifluoromethoxyaniline was added to the reaction solution. After reacting at room temperature for 5 hours, water was added to the reaction solution for extraction. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. After vacuum concentration, it was purified by column chromatography to obtain compound 22 with a yield of 62%; the nuclear magnetic resonance data was 1 H NMR (400MHz, CDCl3) δ8.43 (s, 1H), 7.60 (d, J = 8.8Hz, 2H), 7.20 (d, J = 8.4Hz, 2H), 7.03 (s, 1H), 6.10 (s, 1H), 3.61-3.43 (m, 2H), 1.99 (s, 3H).

[0121] Preparation Example 14: Preparation of Compound 768

[0122] 5 mmol of 5-hydroxy-3-methyl-2(5H)-furanone was dissolved in 10 mL of N,N-dimethylformamide, and then 6 mmol of potassium carbonate and 6 mmol of tert-butyl bromoacetate were added. After heating to 60°C for 3 hours, the mixture was extracted with water and ethyl acetate. The organic phase was washed with saturated brine and dried over anhydrous sodium sulfate. After vacuum concentration, the obtained light yellow solid was purified by column chromatography (yield 62%; NMR data is1 H NMR (400MHz,CDCl3)δ6.97-6.86(m,1H),5.98-5.90(m,1H),4.22(s,2H),1.95(s,3H),1.49(s,9H). The obtained solid was dissolved in 10mL of dichloromethane solution, and then 2mL of trifluoroacetic acid was added. The reaction was carried out at room temperature for 2 hours. The oily product was concentrated in vacuo and subjected to column chromatography to obtain compound I-6 with a yield of 92%. The NMR data was 1 H NMR (400MHz, DMSO-d6) δ12.94 (s, 1H), 7.32-6.97 (m, 1H), 6.07 (m, 1H), 4.27 (d, J = 3.8Hz, 2H), 1.85 (s, 3H);

[0123] 2 mmol of compound I-6 was dissolved in 5 mL of dichloromethane, and then 3 mmol of (7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU) and 5 mmol of triethylamine were added. After stirring at room temperature for 15 minutes, 2.5 mmol of aniline was added to the reaction solution. After reacting at room temperature for 6 hours, water was added to the reaction solution for extraction. The organic phase was washed with 1 mol / L hydrochloric acid and saturated brine, respectively, and dried over anhydrous sodium sulfate, concentrated in vacuo, and then purified by column chromatography to obtain compound 768 with a yield of 58%; the nuclear magnetic resonance data was 1 H NMR (400MHz, CDCl3) δ8.07(s,1H),7.54(d,J=7.6Hz,2H),7.34(t,J=8.0Hz,2H),7.15(t,J =7.6Hz,1H),6.94-6.87(m,1H),5.94(s,1H),4.34(dd,J=35.6,14.8Hz,2H),2.17(s,3H).

[0124] Preparation Example 15: Preparation of Compound 782

[0125] 2 mmol of compound I-6 was dissolved in 5 mL of dichloromethane, and then 3 mmol of (7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU) and 5 mmol of triethylamine were added. After stirring at room temperature for 15 minutes, 2.5 mmol of 3-trifluoromethylaniline was added to the reaction solution. After reacting at room temperature for 5 hours, water was added to the reaction solution for extraction. The organic phase was washed with 1 mol / L hydrochloric acid and saturated brine, respectively, and dried over anhydrous sodium sulfate, concentrated in vacuo, and then purified by column chromatography to obtain compound 782 in a yield of 65%. The NMR data were as follows: 1H NMR (400MHz, CDCl3) δ8.20(s,1H),7.83(s,1H),7.78(d,J=8.0Hz,1H),7.46(t,J=8.0Hz,1H),7. 40(d,J=7.6Hz,1H),6.97-6.91(m,1H),5.96(s,1H),4.37(dd,J=36.4,15.2Hz,2H),2.02(s,3H).

[0126] Preparation Example 16: Preparation of Compound 789

[0127] 2 mmol of compound I-6 was dissolved in 5 mL of dichloromethane, and then 3 mmol of (7-azobenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate (HATU) and 5 mmol of triethylamine were added. After stirring at room temperature for 15 minutes, 2.5 mmol of 4-methylaniline was added to the reaction solution. After reacting at room temperature for 5 hours, water was added to the reaction solution for extraction. The organic phase was washed with 1 mol / L hydrochloric acid and saturated brine, respectively, and dried over anhydrous sodium sulfate, concentrated in vacuo, and then purified by column chromatography to obtain compound 782 in a yield of 60%. The NMR data were as follows: 1 H NMR(400MHz, CDCl3)δ8.01(s,1H),7.42(d,J=7.6Hz,2H),7.14(d,J=7.6Hz,2H),6 .91(s,1H),5.93(s,1H),4.33(dd,J=36.8,14.9Hz,2H),2.32(s,3H),2.00(s,3H).

[0128] Table 1 lists the characterization data of some compounds of the present invention.

[0129] Table 1

[0130] Example 1

[0131] Germination promotion activity test of Blepharma ciliata seeds

[0132] Step 1: Weigh the compound in dimethyl sulfoxide solution, dissolve it and prepare a stock solution with a concentration of 10 mM, and dilute it with water to the required concentration before use; and

[0133] The seeds of Guarana were first soaked in 1% by weight sodium hypochlorite solution for 1 minute, then soaked in 75% by volume ethanol for 1 minute, washed three times with sterile water, and dried in a laminar flow hood.

[0134] Step 2: Place two layers of filter paper at the bottom of a 9 cm diameter Petri dish, wet the bottom with 5 mL of sterile water, evenly spread 9 mm diameter glass fiber filter paper (Whatman GF / A) on the filter paper, and evenly sprinkle sterilized guajava seeds on the filter paper, approximately 40 seeds per piece of filter paper. Seal the Petri dish with Parafilm and pre-incubate in a 30°C incubator for 7 days.

[0135] Step 3: Take out the glass fiber filter paper with the seeds of Guarana, dry the surface water with the filter paper, put it in a 24-well plate, and add 100 μL of 10% dimethyl sulfoxide containing 1% by volume. -7 The germination rate was calculated using a 1 mol / L compound solution sealed with Parafilm and incubated in a 30°C incubator for 3 days. A blank control was a 1 vol% dimethyl sulfoxide solution. Each experiment was repeated 3 times, and the final data was the average of the 3 experiments. The germination promotion rate was calculated according to the following formula:

[0136] Germination rate = number of germinated seeds / total number of seeds * 100%

[0137] The germination promotion rate of the compounds was graded using the following grading method:

[0138] Grade A: 90-100%; Grade B: 80-89%; Grade C: 70-79%; Grade D: 60-69; Grade E: 50-59%; Grade F: 30-49%; Grade G: below 29%.

[0139] The result data are shown in Table 2.

[0140] Table 2

[0141] From the data in Table 2, it can be seen that the compounds of the present invention have a good promoting effect on the germination of Oleander seeds, indicating that the compounds of the present invention can effectively promote the germination of root parasitic weed seeds and can be well used in the field to control root parasitic weeds.

[0142] The present invention exemplarily provides seed germination diagrams of the blank control and the gua gua seeds treated with compound 1, as shown in Figures 1 and 2. It can be clearly seen from the figures that the germination rate of the gua gua seeds treated with the compound provided by the present invention is significantly better than that of the blank control group.

[0143] Example 2

[0144] Wheat seed germination experiment

[0145] Step 1: Weigh the compound in dimethyl sulfoxide solution, dissolve it and prepare a mother solution with a concentration of 1000 ppm, and dilute it with water to the required concentration before use; and

[0146] Wheat seeds were first soaked in 1% by weight sodium hypochlorite solution for 2 minutes, then soaked in 75% by volume ethanol for 2 minutes, washed three times with sterile water, and dried in a laminar flow hood for later use.

[0147] Step 2: Take a 9-cm diameter Petri dish and place two layers of filter paper at the bottom. Evenly sprinkle the sterilized wheat seeds on each filter paper, approximately 30 seeds per piece of filter paper. Add 5 ml of a 20% by volume aqueous solution of PEG6000 containing a 1000 ppm solution of 0.1% by volume of dimethyl sulfoxide. Seal the dish with Parafilm and incubate in a 25°C incubator. Count the germination rate on the fifth day, using the germination standard of either the sprout length reaching the seed length or the root length reaching the seed length. A blank control was made with a 0.1% by volume aqueous solution of dimethyl sulfoxide. Each experiment was repeated three times, and the final data was the average of the three experiments. The germination promotion rate was calculated according to the following formula:

[0148] Germination rate = number of germinated seeds / total number of seeds * 100%

[0149] The result data are shown in Table 3.

[0150] Table 3

[0151] It can be seen from the data in Table 3 that the compounds of the present invention have a good promoting effect on the germination of wheat seeds, indicating that the compounds of the present invention can effectively promote the germination of wheat seeds.

[0152] The present invention exemplarily provides seed germination diagrams of wheat seeds treated with a blank control ( FIG. 3 ), compound 1 ( FIG. 4 ), and compound 768 ( FIG. 5 ). It can be clearly seen from the diagram that the germination rate of wheat seeds treated with the compounds provided by the present invention is significantly better than that of the blank control group.

[0153] Example 3

[0154] Crop yield increase testing

[0155] Step 1: Weigh the compound of the present invention, brassinolide, fluopicolide, and pyraclostrobin in a dimethyl sulfoxide solution, dissolve them, and prepare a stock solution with a concentration of 10 mM. Dilute with water to the desired concentration before use;

[0156] Step 2: When peanuts grow to the flowering needle stage, corn grows to the small trumpet stage, rice grows to the booting stage, and wheat grows to the heading stage, spray the crop leaves with 1% by volume of dimethyl sulfoxide at a concentration of 1×10 -5 mol / L compound solution, 1 volume % dimethyl sulfoxide concentration is 10×10 -5 mol / L compound solution, 1 volume % dimethyl sulfoxide concentration is 100×10 -5 mol / L compound solution, the concentration of dimethyl sulfoxide is 1×10 -5 mol / L of the compound and the concentration of dimethyl sulfoxide is 7×10 -7 mol / L brassinolide solution and the concentration of dimethyl sulfoxide was 20×10 -5 mol / L pyraclostrobin solution (volume ratio of 1:0.1:5), dimethyl sulfoxide concentration of 7×10 -7 mol / L brassinolide solution and the concentration of dimethyl sulfoxide was 20×10 -5 mol / L pyraclostrobin solution (volume ratio of 0.1:5) (see Table 3 for details). The control group was sprayed with a solution containing 1% by volume of dimethyl sulfoxide. Each field plot had an area of ​​25m 2 To reduce errors during harvesting, crops in each plot were harvested manually. After the harvested grain was dried, the grain weight of each treatment plot was weighed. The grain yield increase rate of each plot was calculated according to the following formula:

[0157] Yield increase rate (%) = [(weight of grain harvested in the treatment group - weight of grain harvested in the control group) / weight of grain harvested in the control group] × 100%;

[0158] The result data are shown in Table 4.

[0159] Table 4

[0160] The data in Table 4 show that the compounds of the present invention have excellent yield-increasing effects on wheat, peanuts, corn and rice. The yield-increasing rate of the compounds of the present invention when used in combination with other compounds is better than that of single application, indicating that the compounds of the present invention can effectively promote crop yield increase.

[0161] The present invention exemplarily provides FIG6 and FIG7 as a wheat blank control group and an application of 1×10 -6 mol / L of compound 1 after wheat drought resistance effect diagram. Specifically, Figure 6 is the wheat provided by the present invention after 1×10 -6Figure 6 shows the drought resistance of wheat after treatment with 100 mol / L of compound 1; Figure 7 shows the drought resistance of wheat after treatment with a blank control (CK) provided by the present invention. A comparison of Figures 6 and 7 shows that the compounds provided by the present invention can significantly improve the drought resistance of wheat, further confirming that the compounds provided by the present invention are beneficial for abiotic stress management in plants.

[0162] In addition, the present invention provides a blank control group of cornfield and a control group of cornfields with 4×10 -5 mol / L of Compound 1, as shown in Figure 8, clearly shows that the corn plants in the corn field treated with Compound 1 of the present invention grew more lushly, while the control group showed a drooping and wilting state. This indicates that the compounds of the present invention can effectively promote crop yield.

[0163] In addition, the compounds provided by the present invention can also achieve a yield increase rate of more than 40% on model plants Arabidopsis thaliana and rice under greenhouse experimental conditions. Therefore, it can be predicted that the compounds provided by the present invention have a good yield-increasing effect.

[0164] Furthermore, the data provided in Table 4 of the present invention are the results obtained from field trials. Affected by factors such as pests and diseases and climate, the yield increase rate provided in Table 4 is less than 40%. However, the compounds provided by the present invention have a significant effect on increasing crop yields and have significant prospects for commercial development.

[0165] Example 4

[0166] Arabidopsis root growth promotion experiment

[0167] Plant material: Arabidopsis thaliana (Columbia wild type, Col),

[0168] Sterile culture of Arabidopsis thaliana in a Petri dish

[0169] (1) Sterilization of seeds: Select seeds of uniform size and place them in a 1.5 ml EP tube. Add 1 ml of 75% by volume ethanol and invert for 10 minutes to sterilize. Centrifuge for 30 seconds in a high-speed centrifuge, and then remove the ethanol with a pipette. Add 1 ml of 10% sodium hypochlorite solution to the EP tube, invert for 1 minute, centrifuge for 30 seconds in a high-speed centrifuge, and then remove the sodium hypochlorite solution with a pipette. Wash the seeds 10 times with sterilized deionized water in a sterile clean bench, each time for 30 seconds.

[0170] (2) Preparation of 1 / 2 MS solid medium: Weigh MS powder, 4-morpholineethanesulfonic acid, and sucrose according to the ratios shown in Table 5 below, and dilute to 1 L with deionized water. Measure the pH with a pH meter and adjust the pH to approximately 5.8 with concentrated sodium hydroxide. Dissolve the mixture thoroughly with a stirrer and dispense into 250 ml conical flasks. Add 0.8% agar powder. Sterilize in an autoclave at 120°C for 20 minutes.

[0171] Table 5

[0172] (3) Aseptic culture of Arabidopsis thaliana in a culture dish: In a sterile clean bench, the compound to be tested is prepared into 1 mM with DMSO. After the sterilized culture medium temperature drops to about 60 degrees, 0.1% by volume of DMSO (blank control) or 0.1% by volume of DMSO containing 1 μM of the compound is added; after mixing, pour it into the culture dish. After it cools and solidifies, use a 200ml pipette to absorb the sterilized seeds and dot them one by one on the surface of the solid culture medium in the culture dish. Then, cover the culture dish with a lid and seal it with a Parafilm. The sealed culture dish is placed upside down in the refrigerator and vernalized for three days at 4°C and in the dark. After that, the culture dish is placed upright in an artificial climate incubator at 22°C and 120 photonsμmol m 2 The plants were cultured under 1 s-1 light cycle with a 16-hour light and 8-hour dark cycle, respectively. After ten days of culture, photos were taken and taproot length was measured using Image J.

[0173] Root length growth rate (%) = [(root length of treatment group - root length of control group) / root length of control group] × 100%

[0174] The results are shown in Table 6

[0175] Table 6

[0176] It can be seen from the data in Table 6 that the compounds of the present invention have a significant promoting effect on the root growth of Arabidopsis thaliana.

[0177] The present invention exemplarily provides a blank control ( FIG. 9 ) and a diagram of Arabidopsis root growth after treatment with compound 880 ( FIG. 10 ). It can be clearly seen from the diagram that the root growth of Arabidopsis treated with the compound provided by the present invention is significantly better than that of the blank control group.

[0178] Example 5

[0179] Experimental study on the effects of compounds on soil microbial populations and soil fertility

[0180] A single field was divided into two areas. Area 1 served as the experimental group: Compound 1 was dissolved in a 5% DMSO solution at a dose of 10 g / mu and sprayed on the soil surface every two months for a total of three applications. Area 2 served as the control group: a 5% DMSO solution was sprayed on the soil surface every two months for a total of three applications. One year after the first spraying, approximately 200 g of soil samples were collected from each of the experimental and control plots, placed in sterile, sealed sample bags, and stored in a refrigerator at 4°C. Approximately 10 g of soil samples were also collected and placed in sterile test tubes, quickly frozen in liquid nitrogen, and returned to the laboratory for storage at –80°C.

[0181] Soil fertility determination: Total nitrogen (TN), ammoniacal nitrogen (NH4+-N), nitrate nitrogen (-N), nitrite nitrogen (2-N), total phosphorus (TP), rapidly available phosphorus (AP), total carbon (TC) and total organic carbon (TOC) were determined according to the "Soil Agrochemical Analysis".

[0182] The results are shown in Table 7

[0183] Table 7

[0184] Soil microbial analysis: Soil-extractable microorganisms were stained with DAPI and counted using a flow cytometer (FACS verse, BD Biosciences) at an excitation wavelength of 360 nm and an emission wavelength of 460 nm. High-throughput sequencing (Illumina HiSeq) was used to analyze the community composition of soil microorganisms. DNA was extracted and PCR amplification libraries were constructed. Sequences were filtered using QIIME and aligned to the SILVA132 database with a minimum support threshold of 97%. Microbial community analysis was performed using the Biolog-ECO test plate (ECO MicroPlate, USA).

[0185] The results are shown in Table 8

[0186] Table 8

[0187] Tables 7 and 8 show that the composition of the microbial flora in the soil of the treated group was changed compared to the blank control, and the total carbon, total nitrogen, total phosphorus, and total organic carbon contents were all increased to a certain extent. This shows that the compounds of the present invention can change the microbial population and improve soil fertility.

[0188] Example 6

[0189] Wheat growth promotion experiment

[0190] Test methods

[0191] Wheat (Xinnong 529) dry seeds were soaked in a 1 ppm test solution (a blank control group received a 5% DMSO aqueous solution) for 13 hours, then rinsed three times with clean water. After washing three more times, the seeds were spread out to air-dry and dehydrated. An appropriate amount of vermiculite was added to an 180 ml disposable paper cup. After watering the vermiculite with an appropriate amount of clean water, sowing and incubation began. Each group had 10 replicates. After 16 days of incubation, the wheat plant roots were cleaned to remove impurities and the roots were dehydrated with absorbent paper. Plant height (length from stem base to the end of the longest leaf), root length (length from stem base to the end of the longest fibrous root), total plant fresh weight, root fresh weight, and aboveground fresh weight were measured. ANOVA (completely randomized single-factor statistical analysis with Duncan's new multiple range method) was used.

[0192] The experimental results are shown in Table 9

[0193] Table 9

[0194] It can be seen from the data in Table 9 that the compound of the present invention has a significant promoting effect on the growth of wheat.

[0195] The present invention exemplarily provides wheat growth diagrams after treatment with a blank control ( FIG. 11 ) and compound 1 ( FIG. 12 ). It can be clearly seen from the diagram that the growth of wheat treated with the compound provided by the present invention is significantly better than that of the blank control group.

[0196] The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited thereto. Within the technical concept of the present invention, various simple variations of the technical solution of the present invention may be made, including combining the various technical features in any other appropriate manner. These simple variations and combinations should also be regarded as disclosed in the present invention and fall within the scope of protection of the present invention.

Claims

1. An amide compound, characterized in that The compound has a structure shown in formula (I), Wherein, in formula (I), R 1 and R 2 are each independently selected from H, substituted or unsubstituted C 1-12 Alkyl, substituted or unsubstituted C 3-12 Cycloalkyl, a substituted or unsubstituted C containing at least one heteroatom selected from N, O and S; 1-8 heterocyclic ring, wherein R 7 、R 8 、R 9 、R 10 and R 11 Each is independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 Alkyl, C 3-6 Cycloalkyl, C substituted by 1-9 halogen 1-6 Alkyl, C 1-6 Alkoxy, C substituted by 1-9 halogen 1-6 Alkoxy, C 1-6 Alkylthio, C substituted by 1-9 halogen 1-6 Alkylthio, -COO-C 1-6 Alkyl and -S(O)2-C 1-6 Alkyl, or R 7 、R 8 、R 9 、R 10 、R 11 Any two adjacent ones of the rings are cyclized together to form a 3-8 membered ring structure; And R 1 and R 2 The optional substituents are each independently selected from C 1-12 Alkyl, phenyl; R 3 、R 4 、R 5 and R 6 Each independently selected from H, C 1-12 The alkyl group and C 3-12 Cycloalkyl; n is 0, 1, 2, 3 or 4; X is O, S, -S(O)- or -S(O)2-; Y is O, NH, S, CH2 or -N(CH3)-.

2. The compound according to claim 1, wherein In formula (I), X and Y are not O at the same time.

3. The compound according to claim 2, wherein In formula (I), R 1 and R 2 Each independently selected from H, C 1-6 Alkyl, -(CH2) z -phenyl, an unsaturated five-membered ring group containing a B-type heteroatom, a saturated four-membered ring group containing a B-type heteroatom, an unsaturated six-membered ring group containing a B-type heteroatom, C 4-8 saturated cycloalkyl, benzothiazolyl, benzoxazolyl, benzopyrazolyl, benzothienyl, N-methyl-benzopyrrolyl, z is an integer of 1-6; each of the B-type heteroatoms is independently selected from at least one of O, S, and N; and optionally, the B-type heteroatoms contain C 1-3 An alkyl group as a substituent; Among them, R 7 、R 8 、R 9 、R 10 and R 11 Each is independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 Alkyl, C 3-6 Cycloalkyl, C substituted by 1-6 halogen 1-6 Alkyl, C 1-6 Alkoxy, C substituted by 1-6 halogen 1-6 Alkoxy, C 1-6 Alkylthio, C substituted by 1-3 halogen 1-6 Alkylthio, -COO-C 1-6 Alkyl and -S(O)2-C 1-6 Alkyl, or R 7 、R 8 、R 9 Any two adjacent rings in the ring form a C with or without an O atom. 3-6 A saturated cycloalkane structure; or R 7 、R 8 、R 9 Any two adjacent rings are cyclized together to form a C containing or not containing type A heteroatom 3-6 The unsaturated cycloalkane structure, the A-type heteroatom is selected from at least one of O, S, and N, and optionally, the A-type heteroatom contains C 1-3 An alkyl group as a substituent; R 3 、R 4 、R 5 and R 6 Each independently selected from H, C 1-6 The alkyl group and C 3-6 Cycloalkyl; n is 0, 1, 2, or 3; X is S, -S(O)- or -S(O)2-; Y is O, NH, -CH2- or -N(CH3)-.

4. The compound according to claim 2 or 3, wherein In formula (I), R 1 for Among them, R 7 、R 8 、R 9 、R 10 and R 11 Each is independently selected from H, halogen, nitro, cyano, phenyl, benzyl, C 1-6 Alkyl, C 3-6 Cycloalkyl, C substituted by 1-6 halogen 1-6 Alkyl, C 1-6 Alkoxy, C substituted by 1-6 halogen 1-6 Alkoxy, C 1-6 Alkylthio, C substituted by 1-3 halogen 1-6 Alkylthio, -COO-C 1-6 Alkyl and -S(O)2-C 1-6 Alkyl, or R 7 、R 8 、R 9 Any two adjacent rings in the ring form a C with or without an O atom. 3-6 A saturated cycloalkane structure; or R 7 、R 8 、R 9 Any two adjacent rings are cyclized together to form a C containing or not containing type A heteroatom 3-6 The unsaturated cycloalkane structure, the A-type heteroatom is selected from at least one of O, S, and N, and optionally, the A-type heteroatom contains C 1-3 An alkyl group as a substituent; R 2 、R 5 and R 6 Each is independently selected from H, methyl, ethyl, n-propyl, isopropyl, tert-butyl; or R 2 is phenyl; R 3 and R 4 All are H; n is 0, 1, or 2; X is S, -S(O)- or -S(O)2-; Y is O, NH, -CH2- or -N(CH3)-.

5. The compound according to claim 4, wherein The compound represented by formula (I) has the structure of the compound represented by formula (IA): in, In formula (IA), n, X, Y, R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 The replacement is as follows: Compound 1: n is 0, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 2: n is 0, X is S, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 3: n is 0, X is S, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 4: n is 0, X is S, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 5: n is 0, X is S, Y is O, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 6: n is 0, X is S, Y is O, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 7: n is 0, X is S, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 8: n is 0, X is S, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 9: n is 0, X is S, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 10: n is 0, X is S, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 11: n is 0, X is S, Y is O, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 12: n is 0, X is S, Y is O, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 13: n is 0, X is S, Y is O, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 14: n is 0, X is S, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 15: n is 0, X is S, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 16: n is 0, X is S, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 17: n is 0, X is S, Y is O, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 18: n is 0, X is S, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 19: n is 0, X is S, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 20: n is 0, X is S, Y is O, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 21: n is 0, X is S, Y is O, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 22: n is 0, X is S, Y is O, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 23: n is 0, X is S, Y is O, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 24: n is 0, X is S, Y is O, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 25: n is 0, X is S, Y is O, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 26: n is 0, X is S, Y is O, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 27: n is 0, X is S, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 28: n is 0, X is S, Y is O, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 29: n is 0, X is S, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 30: n is 0, X is S, Y is O, R 6 For Me, R 9 COOC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 31: n is 0, X is S, Y is O, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 32: n is 0, X is S, Y is O, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 33: n is 0, X is S, Y is O, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 34: n is 0, X is S, Y is O, R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 35: n is 0, X is S, Y is O, R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 36: n is 0, X is S, Y is O, R 6 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 37: n is 0, X is S, Y is O, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 38: n is 0, X is S, Y is O, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 39: n is 0, X is S, Y is O, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 40: n is 0, X is S, Y is O, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 874: n is 0, X is S, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 875: n is 0, X is S, Y is O, R 6 For Me, R 8 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 876: n is 0, X is S, Y is O, R 6 For Me, R 9 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 877: n is 0, X is S, Y is O, R 6 For Me, R 7 Ph, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 878: n is 0, X is S, Y is O, R 6 For Me, R 8 Ph, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 879: n is 0, X is S, Y is O, R 6 For Me, R 9 Ph, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 880: n is 0, X is S, Y is O, R 6 For Me, R 7 Bn, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 881: n is 0, X is S, Y is O, R 6 For Me, R 8 Bn, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 882: n is 0, X is S, Y is O, R 6 For Me, R 9 Bn, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 41: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 42: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 43: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 44: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 45: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 46: n is 0, X is S, Y is O, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 47: n is 0, X is S, Y is O, R 6 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 48: n is 0, X is S, Y is O, R 6 、R 7 、R 9 is the average Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 49: n is 0, X is S, Y is O, R 6 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 50: n is 0, X is S, Y is O, R 6 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 51: n is 0, X is S, Y is O, R 6 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 52: n is 0, X is S, Y is O, R 6 、R 7 、R 9 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 53: n is 0, X is S, Y is O, R 6 For Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 54: n is 0, X is S, Y is O, R 6 For Me, R 8 、R 10 For CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 55: n is 0, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 56: n is 0, X is S, Y is O, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 57: n is 0, X is S, Y is O, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 58: n is 0, X is S, Y is O, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 59: n is 0, X is S, Y is O, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 60: n is 0, X is S, Y is O, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 61: n is 0, X is S, Y is O, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 62: n is 0, X is S, Y is O, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 63: n is 0, X is S, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 64: n is 0, X is S, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 65: n is 0, X is S, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 66: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 67: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 68: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 69: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 70: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 71: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 are H; Compound 72: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 73: n is 0, X is S, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 74: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 75: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 76: n is 0, X is S, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 77: n is 0, X is S, Y is O, R 5 For Me, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 78: n is 0, X is S, Y is O, R 5 For Me, R 7 F, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 79: n is 0, X is S, Y is O, R 5 For Me, R 8 F, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 80: n is 0, X is S, Y is O, R 5 For Me, R 9 F, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 81: n is 0, X is S, Y is O, R 5 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 82: n is 0, X is S, Y is O, R 5 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 83: n is 0, X is S, Y is O, R 5 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 84: n is 0, X is S, Y is O, R 5 For Me, R 7 Br, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 85: n is 0, X is S, Y is O, R 5 For Me, R 8 Br, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 86: n is 0, X is S, Y is O, R 5 For Me, R 9 Br, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 87: n is 0, X is S, Y is O, R 5 For Me, R 7 I, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 88: n is 0, X is S, Y is O, R 5 For Me, R 8 I, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 89: n is 0, X is S, Y is O, R 5 For Me, R 9 I, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 90: n is 0, X is S, Y is O, R 5 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 91: n is 0, X is S, Y is O, R 5 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 92: n is 0, X is S, Y is O, R 5 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 93: n is 0, X is S, Y is O, R 5 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 94: n is 0, X is S, Y is O, R 5 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 95: n is 0, X is S, Y is O, R 5 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 96: n is 0, X is S, Y is O, R 5 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 97: n is 0, X is S, Y is O, R 5 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 98: n is 0, X is S, Y is O, R 5 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 99: n is 0, X is S, Y is O, R 5 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 100: n is 0, X is S, Y is O, R 5 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 101: n is 0, X is S, Y is O, R 5 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 102: n is 0, X is S, Y is O, R 5 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 103: n is 0, X is S, Y is O, R 5 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 104: n is 0, X is S, Y is O, R 5 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 105: n is 0, X is S, Y is O, R 5 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 106: n is 0, X is S, Y is O, R 5 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 6 、R 8 、R 7 、R 10 、R 11 All are H; Compound 107: n is 0, X is S, Y is O, R 5 For Me, R 7 CN, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 108: n is 0, X is S, Y is O, R 5 For Me, R 8 CN, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 109: n is 0, X is S, Y is O, R 5 For Me, R 9 CN, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 110: n is 0, X is S, Y is O, R 5 and R 7 For Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 111: n is 0, X is S, Y is O, R 5 and R 8 For Me, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 112: n is 0, X is S, Y is O, R 5 and R 9 For Me, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 113: n is 0, X is S, Y is O, R 5 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 114: n is 0, X is S, Y is O, R 5 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 115: n is 0, X is S, Y is O, R 5 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 116: n is 0, X is S, Y is O, R 5 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 117: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 118: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 All are H; Compound 119: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 11 All are H; Compound 120: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 All are H; Compound 121: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 122: n is 0, X is S, Y is O, R 5 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 All are H; Compound 123: n is 0, X is S, Y is O, R 5 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 124: n is 0, X is S, Y is O, R 5 、R 7 、R 9 is the average Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 All are H; Compound 125: n is 0, X is S, Y is O, R 5 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 11 All are H; Compound 126: n is 0, X is S, Y is O, R 5 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 All are H; Compound 127: n is 0, X is S, Y is O, R 5 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 6 、R 9 、R 10 All are H; Compound 128: n is 0, X is S, Y is O, R 5 、R 7 、R 9 、R 11 Both Me, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 All are H; Compound 129: n is 0, X is S, Y is O, R 5 For Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4 、R 6 、R 8 、R 10 、R 11 All are H; Compound 130: n is 0, X is S, Y is O, R 5 For Me, R 8 、R 10 For CF3, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 11 All are H; Compound 131: n is 0, X is S, Y is O, R 5 For Me, R 2 、R 3 、R 4 、R 6 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 132: n is 0, X is S, Y is O, R 5 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 133: n is 0, X is S, Y is O, R 5 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 134: n is 0, X is S, Y is O, R 5 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 135: n is 0, X is S, Y is O, R 5 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 136: n is 0, X is S, Y is O, R 5 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 137: n is 0, X is S, Y is O, R 5 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 138: n is 0, X is S, Y is O, R 5 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 139: n is 0, X is S, Y is O, R 5 For Me, R 7 for R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 140: n is 0, X is S, Y is O, R 5 For Me, R 7 for R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 141: n is 0, X is S, Y is O, R 5 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 142: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 143: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 144: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 145: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 146: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 147: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 148: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 149: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 150: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 151: n is 0, X is S, Y is O, R 5 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 9 、R 10 、R 11 All are H; Compound 152: n is 0, X is S, Y is O, R 5 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 6 、R 7 、R 10 、R 11 All are H; Compound 153: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 2 、R 3 、R 4 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 154: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 F, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 155: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 F, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 156: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 F, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 157: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 Cl, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 158: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 Cl, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 159: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 Cl, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 160: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 Br, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 161: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 Br, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 162: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 Br, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 163: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 I, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 164: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 I, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 165: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 I, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 166: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 NO2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 167: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 NO2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 168: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 NO2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 169: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CF3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 170: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 CF3, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 171: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 CF3, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 172: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 173: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 174: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 175: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 176: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 177: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 178: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 179: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 180: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 181: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 182: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 8 、R 7 、R 10 、R 11 All are H; Compound 183: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CN, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 184: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 CN, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 185: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 CN, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 186: n is 0, X is S, Y is O, R 5 、R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 187: n is 0, X is S, Y is O, R 5 、R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 188: n is 0, X is S, Y is O, R 5 、R 6 and R 9 For Me, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 189: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 190: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 191: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 192: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 193: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 194: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 8 、R 10 、R 11 All are H; Compound 195: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 8 、R 9 、R 11 All are H; Compound 196: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 All are H; Compound 197: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 198: n is 0, X is S, Y is O, R 5 、R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 8 、R 10 、R 11 All are H; Compound 199: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 200: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 9 is the average Me, R 2 、R 3 、R 4 、R 8 、R 10 、R 11 All are H; Compound 201: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 8 、R 9 、R 11 All are H; Compound 202: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 All are H; Compound 203: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 9 、R 10 All are H; Compound 204: n is 0, X is S, Y is O, R 5 、R 6 、R 7 、R 9 、R 11 Both Me, R 2 、R 3 、R 4 、R 8 、R 10 All are H; Compound 205: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4 、R 8 、R 10 、R 11 All are H; Compound 206: 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 、R 10 For CF3, R 2 、R 3 、R 4 、R 7 、R 9 、R 11 All are H; Compound 207: 0, X is S, Y is O, R 5 、R 6 Both Me, R 2 、R 3 、R 4 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 208: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 209: 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 210: 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 211: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 212: 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 7 、R 9 、R 10 、R 11 All are H; Compound 213: 0, X is S, Y is O, R 5 、R 6 Both Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 7 、R 8 、R 10 、R 11 All are H; Compound 214: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 215: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 216: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 for R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 217: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 for R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 218: 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 8 、R 9 、R 10 、R 11 All are H; Compound 219: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 220: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 221: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 222: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 223: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 224: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 225: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 226: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 227: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 228: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 9 、R 10 、R 11 All are H; Compound 229: n is 0, X is S, Y is O, R 5 、R 6 Both Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 7 、R 10 、R 11 All are H; Compound 230: n is 0, X is S, Y is CH2, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 231: n is 0, X is S, Y is CH2, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 232: n is 0, X is S, Y is CH2, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 233: n is 0, X is S, Y is CH2, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 234: n is 0, X is S, Y is CH2, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 235: n is 0, X is S, Y is CH2, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 236: n is 0, X is S, Y is CH2, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 237: n is 0, X is S, Y is CH2, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 238: n is 0, X is S, Y is CH2, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 239: n is 0, X is S, Y is CH2, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 240: n is 0, X is S, Y is CH2, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 241: n is 0, X is S, Y is CH2, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 242: n is 0, X is S, Y is CH2, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 243: n is 0, X is S, Y is CH2, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 244: n is 0, X is S, Y is CH2, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 245: n is 0, X is S, Y is CH2, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 246: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 247: n is 0, X is S, Y is CH2, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 248: n is 0, X is S, Y is CH2, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 249: n is 0, X is S, Y is CH2, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 250: n is 0, X is S, Y is CH2, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 251: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 252: n is 0, X is S, Y is CH2, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 253: n is 0, X is S, Y is CH2, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 254: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 255: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 256: n is 0, X is S, Y is CH2, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 257: n is 0, X is S, Y is CH2, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 258: n is 0, X is S, Y is CH2, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 259: n is 0, X is S, Y is CH2, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 260: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 261: n is 0, X is S, Y is CH2, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 262: n is 0, X is S, Y is CH2, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 263: n is 0, X is S, Y is CH2, R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 264: n is 0, X is S, Y is CH2, R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 265: n is 0, X is S, Y is CH2, R 6 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 266: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 267: n is 0, X is S, Y is CH2, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 268: n is 0, X is S, Y is CH2, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 269: n is 0, X is S, Y is CH2, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 270: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 271: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 272: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 273: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 274: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 275: n is 0, X is S, Y is CH2, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 276: n is 0, X is S, Y is CH2, R 6 、R 7 、R 8 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 277: n is 0, X is S, Y is CH2, R 6 、R 7 、R 9 is the average Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 278: n is 0, X is S, Y is CH2, R 6 、R 7 、R 10 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 279: n is 0, X is S, Y is CH2, R 6 、R 7 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 280: n is 0, X is S, Y is CH2, R 6 、R 7 、R 8 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 281: n is 0, X is S, Y is CH2, R 6 、R 7 、R 9 、R 11 Both Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 282: n is 0, X is S, Y is CH2, R 6 For Me, R 7 、R 9 For CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 283: n is 0, X is S, Y is CH2, R 6 For Me, R 8 、R 10 For CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 284: n is 0, X is S, Y is CH2, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 285: n is 0, X is S, Y is CH2, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 286: n is 0, X is S, Y is CH2, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 287: n is 0, X is S, Y is CH2, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 288: n is 0, X is S, Y is CH2, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 289: n is 0, X is S, Y is CH2, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 290: n is 0, X is S, Y is CH2, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 291: n is 0, X is S, Y is CH2, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 292: n is 0, X is S, Y is CH2, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 293: n is 0, X is S, Y is CH2, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 294: n is 0, X is S, Y is CH2, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 295: n is 0, X is S, Y is CH2, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 296: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 297: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 298: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 299: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 300: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 300: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 301: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 302: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 303: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 304: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 305: n is 0, X is S, Y is CH2, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 306: n is 0, X is S, Y is CH2, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 307: n is 0, X is S, Y is NMe, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 308: n is 0, X is S, Y is NMe, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 309: n is 0, X is S, Y is NMe, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 310: n is 0, X is S, Y is NMe, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 311: n is 0, X is S, Y is NMe, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 312: n is 0, X is S, Y is NMe, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 313: n is 0, X is S, Y is NMe, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 314: n is 0, X is S, Y is NMe, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 315: n is 0, X is S, Y is NMe, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 316: n is 0, X is S, Y is NMe, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 317: n is 0, X is S, Y is NMe, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 318: n is 0, X is S, Y is NMe, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 319: n is 0, X is S, Y is NMe, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 320: n is 0, X is S, Y is NMe, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 321: n is 0, X is S, Y is NMe, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 322: n is 0, X is S, Y is NMe, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 323: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 324: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 325: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 326: n is 0, X is S, Y is NMe, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 327: n is 0, X is S, Y is NMe, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 328: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 329: n is 0, X is S, Y is NMe, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 330: n is 0, X is S, Y is NMe, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 331: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 332: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 333: n is 0, X is S, Y is NMe, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 334: n is 0, X is S, Y is NMe, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 335: n is 0, X is S, Y is NMe, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 336: n is 0, X is S, Y is NMe, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 337: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 338: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 339: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 340: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 341: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 342: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 343: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 344: n is 0, X is S, Y is NMe, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 345: n is 0, X is S, Y is NMe, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 346: n is 0, X is S, Y is NMe, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 347: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 348: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 349: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 350: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 351: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 352: n is 0, X is S, Y is NMe, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 353: n is 0, X is S, Y is NMe, R 6 、R 7 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 354: n is 0, X is S, Y is NMe, R 6 、R 7 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 355: n is 0, X is S, Y is NMe, R 6 、R 7 and R 10 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 356: n is 0, X is S, Y is NMe, R 6 、R 7 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 357: n is 0, X is S, Y is NMe, R 6 、R 7 、R 8 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 358: n is 0, X is S, Y is NMe, R 6 、R 7 、R 9 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 359: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 9 All are CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 360: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 10 All are CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 361: n is 0, X is S, Y is NMe, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 362: n is 0, X is S, Y is NMe, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 363: n is 0, X is S, Y is NMe, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 364: n is 0, X is S, Y is NMe, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 365: n is 0, X is S, Y is NMe, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 366: n is 0, X is S, Y is NMe, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 367: n is 0, X is S, Y is NMe, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 368: n is 0, X is S, Y is NMe, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 369: n is 0, X is S, Y is NMe, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 370: n is 0, X is S, Y is NMe, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 371: n is 0, X is S, Y is NMe, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 372: n is 0, X is S, Y is NMe, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 373: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 374: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 375: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 376: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 377: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 378: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 379: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 380: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 381: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 382: n is 0, X is S, Y is NMe, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 383: n is 0, X is S, Y is NMe, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 873: n is 0, X is S, Y is NH, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 883: n is 0, X is S, Y is S, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 384: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 385: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 386: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 F, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 387: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 F, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 388: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 389: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 Cl, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 390: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 391: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 Br, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 392: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 Br, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 393: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 Br, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 394: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 I, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 395: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 I, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 396: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 I, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 397: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 NO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 398: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 NO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 399: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 NO2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 400: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 401: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 402: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 403: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 For OCF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 404: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 For OCF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 405: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For OCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 406: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 For OCHF2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 407: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 408: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 409: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For SCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 410: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 For OCH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 411: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 For OCH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 412: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 For OCH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 413: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 OC2H5, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 414: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CN, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 415: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CN, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 416: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CN, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 417: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 418: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 419: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 420: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CH3SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 421: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 422: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 423: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 C2H5SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 424: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 All are Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 425: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 9 All are Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 426: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 10 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 427: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 11 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 428: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 All are Cl, R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 429: n is 0, X is S, Y is O, R 2 、R 6 and R 7 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 430: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 8 For Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 431: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 9 For Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 432: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 10 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 433: n is 0, X is S, Y is O, R 2 、R 6 、R 7 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 434: n is 0, X is S, Y is O, R 2 、R 6 、R 7 、R 8 and R 11 For Me, R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 435: n is 0, X is S, Y is O, R 2 、R 6 、R 7 、R 9 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 436: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 9 All are CF3, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 437: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 10 All are CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 438: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 439: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 is CH3CH2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 440: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 441: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 442: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 is CH(CH3)2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 443: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 444: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 9 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 445: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 446: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 C(CH3)3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 447: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 448: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 449: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 CO2CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 450: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 451: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 452: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 453: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 454: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 455: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 456: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 457: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 458: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 459: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 460: n is 0, X is S, Y is O, R 2 、R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 461: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 462: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 463: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 F, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 464: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 F, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 465: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 466: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 Cl, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 467: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 468: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 Br, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 469: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 Br, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 470: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 Br, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 471: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 I, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 472: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 I, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 473: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 I, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 474: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 NO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 475: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 NO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 476: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 NO2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 477: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 478: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 479: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 480: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 For OCF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 481: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 For OCF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 482: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For OCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 483: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 For OCHF2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 484: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 485: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 486: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For SCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 487: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 For OCH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 488: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 For OCH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 489: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 For OCH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 490: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 OC2H5, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 491: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CN, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 492: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CN, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 493: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CN, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 494: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 495: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 496: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 497: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CH3SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 498: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 499: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 500: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 C2H5SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 501: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 All are Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 502: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 9 All are Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 503: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 10 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 504: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 11 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 505: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 All are Cl, R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 506: n is 0, X is S, Y is O, R 2 For C2H5, R 6 and R 7 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 507: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 and R 8 For Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 508: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 and R 9 For Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 509: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 and R 10 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 510: n is 0, X is S, Y is O, R 2 For C2H5, R 7 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 511: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 、R 8 and R 11 For Me, R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 512: n is 0, X is S, Y is O, R 2 For C2H5, R 6 、R 7 、R 9 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 513: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 9 All are CF3, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 514: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 10 All are CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 515: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 516: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 is CH3CH2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 517: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 518: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 519: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 is CH(CH3)2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 520: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 521: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 9 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 522: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 523: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 C(CH3)3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 524: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 525: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 526: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 CO2CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 527: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 528: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 529: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 530: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 531: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 532: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 533: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 534: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 535: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 536: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 537: n is 0, X is S, Y is O, R 2 For C2H5, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 796: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 797: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 F, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 798: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 F, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 799: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 F, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 800: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 801: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 Cl, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 802: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 803: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 Br, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 804: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 Br, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 805: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 Br, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 806: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 I, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 807: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 I, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 808: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 I, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 809: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 NO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 810: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 NO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 811: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 NO2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 812: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 813: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 814: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 CF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 815: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 For OCF3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 816: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 For OCF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 817: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For OCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 818: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 For OCHF2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 819: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 820: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For OCHF2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 821: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For SCF3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 822: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 For OCH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 823: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 For OCH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 824: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 For OCH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 825: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 OC2H5, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 826: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CN, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 827: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CN, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 828: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 CN, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 829: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 830: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CH3, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 831: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 CH3, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 832: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CH3SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 833: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 834: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 CH3SO2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 835: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 C2H5SO2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 836: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 All are Cl, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 837: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 9 All are Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 838: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 10 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 839: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 11 All are Cl, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 840: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 All are Cl, R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 841: n is 0, X is S, Y is O, R 2 OMe, R 6 and R 7 For Me, R 9 Cl, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 842: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 and R 8 For Me, R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 843: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 and R 9 For Me, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 844: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 and R 10 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 845: n is 0, X is S, Y is O, R 2 OMe, R 7 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 846: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 、R 8 and R 11 For Me, R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 847: n is 0, X is S, Y is O, R 2 OMe, R 6 、R 7 、R 9 and R 11 For Me, R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 848: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 9 All are CF3, R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 849: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 10 All are CF3, R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 850: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 851: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 is CH3CH2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 852: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 853: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 is CH3CH2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 854: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 is CH(CH3)2, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 855: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 856: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 9 is CH(CH3)2, R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 857: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 858: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 C(CH3)3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 859: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 860: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 for R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 861: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 CO2CH3, R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 862: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 863: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 864: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 865: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 866: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 867: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 868: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 869: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 870: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 871: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 7 and R 8 Ring closure formation R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 872: n is 0, X is S, Y is O, R 2 OMe, R 6 For Me, R 8 and R 9 Ring closure formation R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 538: n is 0, X is SO, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 539: n is 0, X is SO, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 540: n is 0, X is SO, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 541: n is 0, X is SO, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 542: n is 0, X is SO, Y is O, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 543: n is 0, X is SO, Y is O, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 544: n is 0, X is SO, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 545: n is 0, X is SO, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 546: n is 0, X is SO, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 547: n is 0, X is SO, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 548: n is 0, X is SO, Y is O, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 549: n is 0, X is SO, Y is O, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 550: n is 0, X is SO, Y is O, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 551: n is 0, X is SO, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 552: n is 0, X is SO, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 553: n is 0, X is SO, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 554: n is 0, X is SO, Y is O, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 555: n is 0, X is SO, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 556: n is 0, X is SO, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 557: n is 0, X is SO, Y is O, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 558: n is 0, X is SO, Y is O, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 559: n is 0, X is SO, Y is O, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 560: n is 0, X is SO, Y is O, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 561: n is 0, X is SO, Y is O, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 562: n is 0, X is SO, Y is O, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 563: n is 0, X is SO, Y is O, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 564: n is 0, X is SO, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 565: n is 0, X is SO, Y is O, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 566: n is 0, X is SO, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 567: n is 0, X is SO, Y is O, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 568: n is 0, X is SO, Y is O, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 569: n is 0, X is SO, Y is O, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 570: n is 0, X is SO, Y is O, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 571: n is 0, X is SO, Y is O, R 6 For Me, R 7 CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 572: n is 0, X is SO, Y is O, R 6 For Me, R 8 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 573: n is 0, X is SO, Y is O, R 6 For Me, R 9 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 574: n is 0, X is SO, Y is O, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 575: n is 0, X is SO, Y is O, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 576: n is 0, X is SO, Y is O, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 577: n is 0, X is SO, Y is O, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 578: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 579: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 580: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 581: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 582: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 583: n is 0, X is SO, Y is O, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 584: n is 0, X is SO, Y is O, R 6 、R 7 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 585: n is 0, X is SO, Y is O, R 6 、R 7 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 586: n is 0, X is SO, Y is O, R 6 、R 7 and R 10 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 587: n is 0, X is SO, Y is O, R 6 、R 7 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 588: n is 0, X is SO, Y is O, R 6 、R 7 、R 8 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 589: n is 0, X is SO, Y is O, R 6 、R 7 、R 9 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 590: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 9 All are CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 591: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 10 All are CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 592: n is 0, X is SO, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 593: n is 0, X is SO, Y is O, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 594: n is 0, X is SO, Y is O, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 595: n is 0, X is SO, Y is O, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 596: n is 0, X is SO, Y is O, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 597: n is 0, X is SO, Y is O, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 598: n is 0, X is SO, Y is O, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 599: n is 0, X is SO, Y is O, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 600: n is 0, X is SO, Y is O, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 601: n is 0, X is SO, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 602: n is 0, X is SO, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 603: n is 0, X is SO, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 604: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 605: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 606: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 607: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 608: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 609: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 610: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、 R 11 All are H; Compound 611: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 612: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 613: n is 0, X is SO, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 614: n is 0, X is SO, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 615: n is 0, X is SO2, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 616: n is 0, X is SO2, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 617: n is 0, X is SO2, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 618: n is 0, X is SO2, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 619: n is 0, X is SO2, Y is O, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 620: n is 0, X is SO2, Y is O, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 621: n is 0, X is SO2, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 622: n is 0, X is SO2, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 623: n is 0, X is SO2, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 624: n is 0, X is SO2, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 625: n is 0, X is SO2, Y is O, R 6 For Me, R 7 I, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 626: n is 0, X is SO2, Y is O, R 6 For Me, R 8 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 627: n is 0, X is SO2, Y is O, R 6 For Me, R 9 I, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 628: n is 0, X is SO2, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 629: n is 0, X is SO2, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 630: n is 0, X is SO2, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 631: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 632: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 633: n is 0, X is SO2, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 634: n is 0, X is SO2, Y is O, R 6 For Me, R 7 For OCF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 635: n is 0, X is SO2, Y is O, R 6 For Me, R 8 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 636: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For OCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 637: n is 0, X is SO2, Y is O, R 6 For Me, R 7 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 638: n is 0, X is SO2, Y is O, R 6 For Me, R 8 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 639: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For OCHF2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 640: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For SCF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 641: n is 0, X is SO2, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 642: n is 0, X is SO2, Y is O, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 643: n is 0, X is SO2, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 644: n is 0, X is SO2, Y is O, R 6 For Me, R 9 OC2H5, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 645: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CN, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 646: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 647: n is 0, X is SO2, Y is O, R 6 For Me, R 9 CN, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 648: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 649: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 650: n is 0, X is SO2, Y is O, R 6 For Me, R 9 CH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 651: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 652: n is 0, X is SO2, Y is O, R 6 For Me, R 8 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 653: n is 0, X is SO2, Y is O, R 6 For Me, R 9 CH3SO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 654: n is 0, X is SO2, Y is O, R 6 For Me, R 7 C2H5SO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 655: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 All are Cl, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 656: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 657: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 10 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 658: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 11 All are Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 659: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 All are Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 660: n is 0, X is SO2, Y is O, R 6 and R 7 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 661: n is 0, X is SO2, Y is O, R 6 、R 7 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 662: n is 0, X is SO2, Y is O, R 6 、R 7 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 663: n is 0, X is SO2, Y is O, R 6 、R 7 and R 10 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 11 All are H; Compound 664: n is 0, X is SO2, Y is O, R 6 、R 7 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 All are H; Compound 665: n is 0, X is SO2, Y is O, R 6 、R 7 、R 8 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 9 、R 10 All are H; Compound 666: n is 0, X is SO2, Y is O, R 6 、R 7 、R 9 and R 11 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 All are H; Compound 667: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 9 All are CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 10 、R 11 All are H; Compound 668: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 10 All are CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 11 All are H; Compound 669: n is 0, X is SO2, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 Both H, R 7 、R 8 、R 9 、R 10 、R 11 All are F; Compound 670: n is 0, X is SO2, Y is O, R 6 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 671: n is 0, X is SO2, Y is O, R 6 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 672: n is 0, X is SO2, Y is O, R 6 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 673: n is 0, X is SO2, Y is O, R 6 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 674: n is 0, X is SO2, Y is O, R 6 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 675: n is 0, X is SO2, Y is O, R 6 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 676: n is 0, X is SO2, Y is O, R 6 For Me, R 7 is CH3(CH2)2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 677: n is 0, X is SO2, Y is O, R 6 For Me, R 7 C(CH3)3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 678: n is 0, X is SO2, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 679: n is 0, X is SO2, Y is O, R 6 For Me, R 7 for R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 680: n is 0, X is SO2, Y is O, R 6 For Me, R 7 CO2CH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 681: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 682: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 683: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 684: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 685: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 686: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 687: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 688: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 689: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 690: n is 0, X is SO2, Y is O, R 6 For Me, R 7 and R 8 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 9 、R 10 、R 11 All are H; Compound 691: n is 0, X is SO2, Y is O, R 6 For Me, R 8 and R 9 Ring closure formation R 2 、R 3 、R 4 、R 5 、R 7 、R 10 、R 11 All are H; Compound 692: n is 1, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 693: n is 2, X is S, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 697: n is 0, X is S, Y is O, R 2 for R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 Both H, R 6 For CH3.

6. The compound according to claim 2 or 3, wherein In formula (I), R 1 Selected from C 1-6 Alkyl, -(CH2) z -phenyl, an unsaturated five-membered ring group containing a B-type heteroatom, a saturated four-membered ring group containing a B-type heteroatom, an unsaturated six-membered ring group containing a B-type heteroatom, C 4-8 saturated cycloalkyl, benzothiazolyl, benzoxazolyl, benzopyrazolyl, benzothienyl, N-methyl-benzopyrrolyl, z is an integer of 1-6; each of the B-type heteroatoms is independently selected from at least one of O, S, and N; and optionally, the B-type heteroatoms contain C 1-3 An alkyl group as a substituent; R 2 Selected from H, n-butyl, -CH2-phenyl; R 3 、R 4 and R 5 Both H; R 6 is methyl; n is 0; X is S; and Y is O.

7. The compound according to claim 6, wherein In formula (I), n, X, Y, R 1 、R 2 、R 3 、R 4 、R 5 、R 6 The replacement is as follows: Compound 694: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 695: n is 0, X is S, Y is O, R 1 for R 2 H, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 696: n is 0, X is S, Y is O, R 1 for R 2 for R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 698: n is 0, X is S, Y is O, R 1 CH3, R 2 CH3, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 699: n is 0, X is S, Y is O, R 1 is CH3CH2, R 2 CH3, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 700: n is 0, X is S, Y is O, R 1 is CH3CH2, R 2 is CH3CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 701: n is 0, X is S, Y is O, R 1 (CH3)2CH2, R 2 (CH3)2CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 702: n is 0, X is S, Y is O, R 1 (CH3)2CH2, R 2 is CH3CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 703: n is 0, X is S, Y is O, R 1 is CH3CH3CH2, R 2 is CH3CH3CH2, R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 704: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 705: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 706: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 707: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 708: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 709: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 710: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 711: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 712: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 713: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 714: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 715: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 716: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 717: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 718: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 719: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 720: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 721: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 722: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 723: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 724: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 725: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 726: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 727: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 728: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 729: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 730: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 731: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 732: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 733: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 734: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 735: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 736: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 737: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 738: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 739: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 740: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 741: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 742: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 743: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 744: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 745: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 746: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 747: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 748: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 749: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 750: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 751: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 752: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 753: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 754: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 755: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 756: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 757: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 758: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 759: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 760: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 761: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 762: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 763: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 764: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 765: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 766: n is 0, X is S, Y is O, R 1 for R 2 、R 3 、R 4 、R 5 Both H, R 6 is CH3; Compound 767: n is 0, X is S, Y is O, R 1 is CH3(CH2)3, R 2 is CH3(CH2)3, R 3 、R 4 、R 5 Both H, R 6 For CH3.

8. The compound according to claim 1, wherein In formula (I), X and Y are both O; Preferably, the compound represented by formula (I) has the structure of the compound represented by formula (IA): Wherein, in formula (IA), n, X, Y, R 2 、R 3 、R 4 、R 5 、R 6 、R 7 、R 8 、R 9 、R 10 、R 11 The replacement is as follows: Compound 768: n is 0, X is O, Y is O, R 6 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 9 、R 10 、R 11 All are H; Compound 769: n is 0, X is O, Y is O, R 6 For Me, R 7 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 770: n is 0, X is O, Y is O, R 6 For Me, R 8 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 771: n is 0, X is O, Y is O, R 6 For Me, R 9 F, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 772: n is 0, X is O, Y is O, R 6 For Me, R 7 Cl, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 773: n is 0, X is O, Y is O, R 6 For Me, R 8 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 774: n is 0, X is O, Y is O, R 6 For Me, R 9 Cl, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 775: n is 0, X is O, Y is O, R 6 For Me, R 7 Br, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 776: n is 0, X is O, Y is O, R 6 For Me, R 8 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 777: n is 0, X is O, Y is O, R 6 For Me, R 9 Br, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 778: n is 0, X is O, Y is O, R 6 For Me, R 7 NO2, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 779: n is 0, X is O, Y is O, R 6 For Me, R 8 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 780: n is 0, X is O, Y is O, R 6 For Me, R 9 NO2, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 781: n is 0, X is O, Y is O, R 6 For Me, R 7 CF3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 782: n is 0, X is O, Y is O, R 6 For Me, R 8 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 783: n is 0, X is O, Y is O, R 6 For Me, R 9 CF3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 784: n is 0, X is O, Y is O, R 6 For Me, R 7 For OCH3, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 785: n is 0, X is O, Y is O, R 6 For Me, R 8 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 786: n is 0, X is O, Y is O, R 6 For Me, R 9 For OCH3, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 787: n is 0, X is O, Y is O, R 6 and R 7 For Me, R 2 、R 3 、R 4 、R 5 、R 8 、R 9 、R 10 、R 11 All are H; Compound 788: n is 0, X is O, Y is O, R 6 and R 8 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 9 、R 10 、R 11 All are H; Compound 789: n is 0, X is O, Y is O, R 6 and R 9 For Me, R 2 、R 3 、R 4 、R 5 、R 7 、R 8 、R 10 、R 11 All are H; Compound 790: n is 0, X is O, Y is O, R 5 For Me, R 7 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 791: n is 0, X is O, Y is O, R 5 For Me, R 8 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 792: n is 0, X is O, Y is O, R 5 For Me, R 9 is CH3CH2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 All are H; Compound 793: n is 0, X is O, Y is O, R 5 For Me, R 7 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 8 、R 9 、R 10 、R 11 All are H; Compound 794: n is 0, X is O, Y is O, R 5 For Me, R 8 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7 、R 9 、R 10 、R 11 All are H; Compound 795: n is 0, X is O, Y is O, R 5 For Me, R 9 is CH(CH3)2, R 2 、R 3 、R 4 、R 6 、R 7 、R 8 、R 10 、R 11 Both are H.

9. A method for preparing the amide compound according to any one of claims 1 to 8, characterized in that: The method comprises: contacting a compound represented by formula (V-1) with a compound represented by formula (V-2); Wherein, the substitution of the substituents in formula (V-1) and formula (V-2) corresponds to the same substitution as that in the amide compound described in any one of claims 1 to 8, and one of Z1 and Z2 is -Br and the other is -XH, and the definition of X corresponds to the same definition as that in the amide compound described in any one of claims 1 to 8.

10. A method for preparing the amide compound according to any one of claims 1 to 8, characterized in that: The method comprises: performing a coupling reaction on a compound represented by formula (II) and a compound represented by formula (III); The substitution conditions of the substituents in formula (III) and formula (II) are the same as those in the amide compound according to any one of claims 1 to 8.

11. Use of the amide compound according to any one of claims 1 to 8 in agronomy; Preferably, the application in agronomy is selected from at least one of increasing crop yield, managing abiotic stress on plants, regulating plant growth, enhancing plant disease resistance, promoting seed germination, regulating soil microbial population structure and improving soil fertility.

12. A biostimulant, characterized in that The biostimulant contains an effective amount for regulating plant growth of at least one of the amide compounds according to any one of claims 1 to 8, and optionally contains an auxiliary material; Preferably, the content of the amide compound is 1-99.99 wt %, or the content of the amide compound is 0.001 ppm-100 ppm.

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