Soothing composition containing trans-4-tert-butyl cyclohexanol

Abstract

The invention relates to a soothing composition containing trans-4-tert-butyl cyclohexanol, and belongs to the technical field of cosmetics. The soothing composition comprises a main agent; the main agent is prepared from trans-4-tert-butyl cyclohexanol, nordihydroguaiamic acid and troxerutin; the soothing composition further comprises an auxiliary agent; the auxiliary agent is prepared by the following steps: S1, pretreating white water lily roots to obtain white water lily root powder; s2, pretreating the roots of the buckthorn to obtain powder of the roots of the buckthorn; s3, extracting active substances of the white water lily root powder and the buckthorn root powder in a deionized water environment under the action of cellulase; the soothing composition is high in safety adaptability and easy to accept by skin, sensitivity irritation is reduced, the components have a prominent synergistic effect on the soothing effect, and further application of trans-4-tert-butyl cyclohexanol in the field of cosmetics is promoted.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a soothing composition containing trans-4-tert-butylcyclohexanol. Background Technology

[0002] Trans-4-tert-butylcyclohexanol is a cyclohexanol compound with a specific stereochemical configuration. Its tert-butyl substituent is located at the 4-position of the cyclohexane skeleton and exists in the trans conformation, resulting in a relatively stable molecule. This spatial structure gives it a certain degree of physicochemical stability in topical formulations and allows it to participate in modulating the skin's perception of external stimuli. Studies have shown that trans-4-tert-butylcyclohexanol can reduce discomfort caused by irritants, such as stinging, erythema, and burning sensations. Based on these properties, trans-4-tert-butylcyclohexanol has been introduced into the cosmetics industry as a functional ingredient with soothing effects.

[0003] Based on current applications, trans-4-tert-butylcyclohexanol still has significant shortcomings. Firstly, its synergistic effect with other active ingredients in multi-component systems is not prominent, and its soothing properties are often difficult to enhance significantly under compounding conditions, limiting its application value. More importantly, the safety and suitability of trans-4-tert-butylcyclohexanol when used in combination with other active ingredients still lacks validation. Due to potential molecular-level interactions between different components, synergy may alter the skin microenvironment or affect the mechanism of action of active substances, leading to an increased risk of irritation. In such cases, the expected soothing effect may be difficult to achieve effectively, potentially causing additional skin irritation or even inducing or aggravating existing discomfort.

[0004] In conclusion, in order to further promote the application of trans-4-tert-butylcyclohexanol in the cosmetics field, more in-depth technical improvements are urgently needed in terms of synergy and safety adaptability. Summary of the Invention

[0005] The present invention aims to solve one or more technical problems existing in the prior art, and at least provide a beneficial alternative. Specifically, the present invention provides a soothing composition containing trans-4-tert-butylcyclohexanol, which exhibits a prominent synergistic effect among its components in terms of soothing effect, reduces sensitivity and irritation, has high safety and adaptability, and promotes the application of trans-4-tert-butylcyclohexanol in the cosmetics field.

[0006] To achieve this objective, the present invention adopts the following technical solution:

[0007] A soothing composition containing trans-4-tert-butylcyclohexanol, the soothing composition comprising a main agent; the main agent comprising trans-4-tert-butylcyclohexanol, nordihydroguaiacol, and troxerutin.

[0008] In a preferred embodiment of the present invention, the main agent comprises 40-55 parts by weight of trans-4-tert-butylcyclohexanol, 18-26 parts by weight of nordihydroguaiacol, and 12-15 parts by weight of troxerutin.

[0009] In a preferred embodiment of the present invention, the soothing composition further includes an adjuvant; the weight ratio of the main agent to the adjuvant is 12-18:5-5.8.

[0010] Preferably, the auxiliary agent is prepared by the following steps:

[0011] S1. Take white water lily roots, wash them, dry them and grind them into powder to obtain white water lily root powder.

[0012] S2. Take the roots of the night-blooming jasmine, wash them, and then dry and grind them into powder to obtain night-blooming jasmine root powder.

[0013] S3. Add white water lily root powder and eggplant root powder to deionized water, disperse by ultrasonication, add cellulase, perform enzymatic hydrolysis under controlled temperature, inactivate the enzyme, cool, and then centrifuge, filter, and spray dry in sequence.

[0014] Most preferably, in step S1, the drying temperature is 40-45℃ and the time is 18-24h.

[0015] Most preferably, in step S1, after the powdering is completed, it needs to be passed through an 80-100 mesh sieve.

[0016] Most preferably, in step S2, the drying temperature is 40-45℃ and the time is 18-24h.

[0017] Most preferably, in step S2, after the powdering is completed, it needs to be passed through an 80-100 mesh sieve.

[0018] Most preferably, in step S3, the weight ratio of the white water lily root powder to the eggplant root powder is 26-54:35-48; the weight of the deionized water is 14-22 times the total weight of the white water lily root powder and the eggplant root powder; and the weight of the cellulase is 1-2.7% of the total weight of the white water lily root powder and the eggplant root powder.

[0019] Most preferably, in step S3, the ultrasonic dispersion time is 3-8 min, the power is 200-400 W, the temperature is 25 °C, and the rotation speed is 150-200 r / min.

[0020] Most preferably, in step S3, the cellulase activity is 8000-10000 U / g.

[0021] Most preferably, in step S3, the temperature-controlled enzymatic hydrolysis refers to heating to 48-58°C in reflux at a rotation speed of 150-200 r / min, followed by constant temperature treatment for 90-120 min.

[0022] Most preferably, in step S3, enzyme inactivation refers to treatment in a reflux condensation process at a water bath of 90-100°C for 10 minutes.

[0023] Most preferably, in step S3, the cooling refers to condensation and reflux treatment in a water bath at 15-25°C for 5-10 minutes.

[0024] Most preferably, in step S3, the centrifugation time is 5-10 min, the rotation speed is 6000-10000 r / min, and the temperature is 25-30℃.

[0025] Most preferably, in step S3, the filtration accuracy is 0.45-1 μm.

[0026] In a preferred embodiment of the present invention, the content of the soothing composition in the cosmetic after it is prepared is 1-1.3 wt%; the type of the cosmetic is not particularly limited, but those skilled in the art should know that these types can be creams, toners, lotions, facial cleansers, serums, etc.

[0027] The beneficial effects of the technical solution of this invention:

[0028] This invention optimizes the overall soothing performance through the synergistic function of multiple components, wherein the main agents include trans-4-tert-butylcyclohexanol, nordihydroguaiacol, and troxerutin. Trans-4-tert-butylcyclohexanol, as a key soothing agent, primarily works at the level of skin stimulation perception. It can intervene in the transmission process of external stimulus signals in the skin, reducing the skin's reaction to adverse stimuli, thereby inhibiting the development of discomfort in the initial stage. It has excellent soothing effects on skin problems such as redness, burning, itching, and stinging. Nordihydroguaiac acid starts from the generation and transformation of key reaction factors in the stimulation process, intervening in the formation and persistence of related mediators under stimulation conditions, reducing the continuation and accumulation of discomfort over time. Troxerutin focuses on supporting the stability of skin function. By improving the skin's overall tolerance to external stimuli, it makes the stimulation response less likely to be further aggravated, weakening the amplification effect of stimulation signals. Although the above ingredients exert soothing effects through different pathways of action, it has been found in application that the main agent has the risk of sensitization and negative effects. Irritation is difficult to be completely neutralized. In some cases, it not only affects the stable performance of its soothing effect, but may even aggravate skin discomfort. To address this pain point, this invention further introduces an auxiliary agent, which is an extract obtained by enzymatic hydrolysis of white water lily root powder and nightshade root powder using cellulase. This auxiliary agent releases affinity and soothing components through enzymatic hydrolysis, and has a regulatory and buffering effect on sensitive and irritating reactions, helping to reduce the risk of sensitivity during the use of the main agent. It should be noted that if either of the plant sources is missing or if enzymatic hydrolysis is not performed during the preparation of the auxiliary agent, the stimulation regulation effect will be impaired, and the soothing effect will also be weakened.

[0029] The soothing composition provided by this invention exhibits a remarkable synergistic effect among its components, balancing synergy with safety and adaptability, and promoting the further application of trans-4-tert-butylcyclohexanol in the cosmetics field. Detailed Implementation

[0030] Preferred embodiments of the invention will now be described in more detail. While preferred embodiments of the invention have been shown, it should be understood that the invention can be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that the invention will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.

[0031] The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular forms “a” and “the” as used in this invention and the appended claims are intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the term “and / or” as used herein refers to and includes any or all possible combinations of one or more of the associated listed items.

[0032] Unless otherwise specified, the ingredients mentioned in the following examples are all cosmetic grade raw materials, which can be purchased from ordinary commercial sources; the white water lily root and the nightshade root were purchased from a Chinese herbal medicine farmers' market.

[0033] Example 1

[0034] A soothing composition containing trans-4-tert-butylcyclohexanol, the soothing composition comprising a main agent; the main agent comprising 40 parts by weight of trans-4-tert-butylcyclohexanol, 18 parts by weight of nordihydroguaiacol and 12 parts by weight of troxerutin.

[0035] The soothing composition further includes an adjuvant; the weight ratio of the main agent to the adjuvant is 12:5.

[0036] The auxiliary agent is prepared through the following steps:

[0037] S1. Take white water lily roots, wash them, dry them and grind them into powder to obtain white water lily root powder.

[0038] S2. Take the roots of the night-blooming jasmine, wash them, and then dry and grind them into powder to obtain night-blooming jasmine root powder.

[0039] S3. Add white water lily root powder and eggplant root powder to deionized water, disperse by ultrasonication, add cellulase, perform enzymatic hydrolysis under controlled temperature, inactivate the enzyme, cool, and then centrifuge, filter the supernatant, and spray dry the filtrate in sequence.

[0040] In steps S1 and S2, the cleaning refers to cleaning with deionized water.

[0041] In step S1, the drying temperature is 45°C and the drying time is 18 hours.

[0042] In step S1, after the powdering is completed, it needs to be passed through a 100-mesh sieve.

[0043] In step S2, the drying temperature is 40°C and the drying time is 24 hours.

[0044] In step S2, after the powdering is completed, it needs to be passed through a 100-mesh sieve.

[0045] In step S3, the weight ratio of the white water lily root powder to the eggplant root powder is 26:35; the weight of the deionized water is 14 times the total weight of the white water lily root powder and the eggplant root powder; and the weight of the cellulase is 1% of the total weight of the white water lily root powder and the eggplant root powder.

[0046] In step S3, the ultrasonic dispersion time is 3 min, the power is 200 W, the temperature is 25 °C, and the rotation speed is 150 r / min.

[0047] In step S3, the cellulase activity is 8000 U / g.

[0048] In step S3, the temperature-controlled enzymatic hydrolysis refers to heating to 48°C at a heating rate of 2°C / min in reflux at a rotation speed of 150 r / min, followed by constant temperature treatment for 90 min.

[0049] In step S3, enzyme inactivation refers to treatment in a reflux condensation process at 90°C for 10 minutes.

[0050] In step S3, the cooling refers to reflux treatment in a 15°C water bath for 5 minutes.

[0051] In step S3, the centrifugation time is 5 minutes, the rotation speed is 10,000 r / min, and the temperature is 25°C.

[0052] In step S3, the filtration accuracy is 1 μm.

[0053] In step S3, the inlet air temperature of the spray dryer is 180°C and the outlet air temperature is 75°C.

[0054] The soothing composition is prepared simply by mixing the main agent and the auxiliary agent; the content of the soothing composition in the cosmetic product is 1 wt%.

[0055] Example 2

[0056] A soothing composition containing trans-4-tert-butylcyclohexanol, the soothing composition comprising a main agent; the main agent comprising 52 parts by weight of trans-4-tert-butylcyclohexanol, 20 parts by weight of nordihydroguaiacol and 14 parts by weight of troxerutin.

[0057] The soothing composition further includes adjuvants; the weight ratio of the main agent to the adjuvants is 14:5.5.

[0058] The auxiliary agent is prepared through the following steps:

[0059] S1. Take white water lily roots, wash them, dry them and grind them into powder to obtain white water lily root powder.

[0060] S2. Take the roots of the night-blooming jasmine, wash them, and then dry and grind them into powder to obtain night-blooming jasmine root powder.

[0061] S3. Add white water lily root powder and eggplant root powder to deionized water, disperse by ultrasonication, add cellulase, perform enzymatic hydrolysis under controlled temperature, inactivate the enzyme, cool, and then centrifuge, filter the supernatant, and spray dry the filtrate in sequence.

[0062] In steps S1 and S2, the cleaning refers to cleaning with deionized water.

[0063] In step S1, the drying temperature is 40°C and the time is 24 hours.

[0064] In step S1, after the powdering is completed, it needs to be passed through a 100-mesh sieve.

[0065] In step S2, the drying temperature is 40°C and the drying time is 24 hours.

[0066] In step S2, after the powdering is completed, it needs to be passed through a 100-mesh sieve.

[0067] In step S3, the weight ratio of the white water lily root powder to the eggplant root powder is 40:35; the weight of the deionized water is 18 times the total weight of the white water lily root powder and the eggplant root powder; and the weight of the cellulase is 2% of the total weight of the white water lily root powder and the eggplant root powder.

[0068] In step S3, the ultrasonic dispersion time is 5 min, the power is 400 W, the temperature is 25 °C, and the rotation speed is 200 r / min.

[0069] In step S3, the cellulase activity is 10000 U / g.

[0070] In step S3, the temperature-controlled enzymatic hydrolysis refers to heating to 56°C at a heating rate of 2°C / min in reflux at a rotation speed of 200 r / min, followed by constant temperature treatment for 100 min.

[0071] In step S3, enzyme inactivation refers to treatment in a reflux condensation process at 90°C for 10 minutes.

[0072] In step S3, the cooling refers to condensation and reflux treatment in a 25°C water bath for 10 minutes.

[0073] In step S3, the centrifugation time is 5 minutes, the rotation speed is 10,000 r / min, and the temperature is 25°C.

[0074] In step S3, the filtration accuracy is 1 μm.

[0075] In step S3, the inlet air temperature of the spray dryer is 180°C and the outlet air temperature is 70°C.

[0076] The soothing composition is prepared simply by mixing the main agent and the auxiliary agent; the content of the soothing composition in the cosmetic product is 1.2 wt%.

[0077] Example 3

[0078] A soothing composition containing trans-4-tert-butylcyclohexanol, the soothing composition comprising a main agent; the main agent comprising 55 parts by weight of trans-4-tert-butylcyclohexanol, 26 parts by weight of nordihydroguaiacol and 15 parts by weight of troxerutin.

[0079] The soothing composition further includes an adjuvant; the weight ratio of the main agent to the adjuvant is 18:5.8.

[0080] The auxiliary agent is prepared through the following steps:

[0081] S1. Take white water lily roots, wash them, dry them and grind them into powder to obtain white water lily root powder.

[0082] S2. Take the roots of the night-blooming jasmine, wash them, and then dry and grind them into powder to obtain night-blooming jasmine root powder.

[0083] S3. Add white water lily root powder and eggplant root powder to deionized water, disperse by ultrasonication, add cellulase, perform enzymatic hydrolysis under controlled temperature, inactivate the enzyme, cool, and then centrifuge, filter the supernatant, and spray dry the filtrate in sequence.

[0084] In steps S1 and S2, the cleaning refers to cleaning with deionized water.

[0085] In step S1, the drying temperature is 45°C and the drying time is 24 hours.

[0086] In step S1, after the powdering is completed, it needs to be passed through a 100-mesh sieve.

[0087] In step S2, the drying temperature is 42°C and the drying time is 22 hours.

[0088] In step S2, after the powdering is completed, it needs to be passed through an 80-mesh sieve.

[0089] In step S3, the weight ratio of the white water lily root powder to the eggplant root powder is 54:48; the weight of the deionized water is 22 times the total weight of the white water lily root powder and the eggplant root powder; and the weight of the cellulase is 2.7% of the total weight of the white water lily root powder and the eggplant root powder.

[0090] In step S3, the ultrasonic dispersion time is 8 min, the power is 300 W, the temperature is 25 °C, and the rotation speed is 150 r / min.

[0091] In step S3, the cellulase activity is 8000 U / g.

[0092] In step S3, the temperature-controlled enzymatic hydrolysis refers to heating to 58°C at a heating rate of 2°C / min in reflux at a rotation speed of 200 r / min, followed by constant temperature treatment for 120 min.

[0093] In step S3, enzyme inactivation refers to treatment in a reflux condensation process at 100°C for 10 minutes.

[0094] In step S3, the cooling refers to condensing and refluxing in a 20°C water bath for 10 minutes.

[0095] In step S3, the centrifugation time is 10 min, the rotation speed is 10000 r / min, and the temperature is 25℃.

[0096] In step S3, the filtration accuracy is 0.45 μm.

[0097] In step S3, the inlet air temperature of the spray dryer is 175°C and the outlet air temperature is 75°C.

[0098] The soothing composition is prepared simply by mixing the main agent and the auxiliary agent; the content of the soothing composition in the cosmetic product is 1.3 wt%.

[0099] Comparative Example 1

[0100] The only difference between this comparative example and Example 2 is that in this comparative example, trans-4-tert-butylcyclohexanol is replaced by an equal weight of nordihydroguaiaric acid and troxerutin in a weight ratio of 20:14, while all other aspects remain unchanged.

[0101] Comparative Example 2

[0102] The only difference between this comparative example and Example 2 is that in this comparative example, trans-4-tert-butylcyclohexanol and troxerutin in a weight ratio of 52:14 are used to replace nordihydroguaiaric acid, while all other aspects remain unchanged.

[0103] Comparative Example 3

[0104] The only difference between this comparative example and Example 2 is that troxerutin is replaced by trans-4-tert-butylcyclohexanol and nordihydroguaiaric acid in a weight ratio of 52:20 in this comparative example, while all other aspects remain unchanged.

[0105] Comparative Example 4

[0106] The only difference between this comparative example and Example 2 is that the root powder of nightshade was replaced with an equal weight of white water lily root powder in this comparative example, while all other aspects remained unchanged.

[0107] Comparative Example 5

[0108] The only difference between this comparative example and Example 2 is that the white water lily root powder is replaced with an equal weight of the eggplant root powder in this comparative example, while all other aspects remain unchanged.

[0109] Comparative Example 6

[0110] The only difference between this comparative example and Example 2 is that deionized water was used to replace cellulase by weight in this comparative example, while all other aspects remained the same.

[0111] Comparative Example 7

[0112] The only difference between this comparative example and Example 2 is that the main agent is replaced with the auxiliary agent by the same weight in this comparative example, and everything else remains the same.

[0113] Comparative Example 8

[0114] The only difference between this comparative example and Example 2 is that the main agent is replaced by an auxiliary agent of equal weight in this comparative example, while all other aspects remain unchanged.

[0115] Comparative Example 9

[0116] The only difference between this comparative example and Example 2 is that the main agent is replaced by trans-4-tert-butylcyclohexanol by weight in this comparative example, while all other aspects remain unchanged.

[0117] Preparation Example 1

[0118] The soothing compositions of Example 2 and Comparative Examples 1-9 were prepared into soothing cosmetics according to the soothing cosmetic formulations in Table 1 below.

[0119] Table 1. Formulas for Soothing Cosmetics

[0120]

[0121] Preparation steps of soothing cosmetics: Heat deionized water to 65℃ and keep it warm. Then add glycerin, 1,2-butanediol, D-panthenol, xanthan gum, caprylic / capric triglyceride and polysorbate-60. Then stir and mix under reflux at 200 r / min for 15 min. Let it cool naturally to 25℃. Finally, add the soothing composition and homogenize at 2500 r / min for 5 min.

[0122] Blank cosmetic preparation steps: Replace the soothing composition with deionized water by weight in the aforementioned soothing cosmetic preparation steps, while keeping everything else unchanged, and the blank cosmetic is obtained.

[0123] Test Example 1

[0124] The test includes the following steps:

[0125] Step (1): Using a computer, 300 volunteers with similar skin types were randomly selected and grouped into 10 groups of 30 people each. The 10 groups corresponded to the 10 kinds of soothing cosmetics prepared in Example 1.

[0126] Step (2): Divide the inner side of the volunteer's right forearm into two areas with a gap of more than 2cm between the areas and a size of 3cm*3cm, and label them as area A and area B. Use 3M tape to tear the skin of area A and area B 15 times each. Then apply non-woven fabric fully soaked in 10mg / mL histamine aqueous solution to the skin surface of area A and area B for 10 minutes. Remove the fabric and test the skin erythema index of area A and area B for the first time.

[0127] Step (3): Apply the corresponding soothing cosmetic to area A, and apply the blank cosmetic prepared in Preparation Example 1 to area B. The application amount is 3 mg / cm².2 After 20 minutes of application, the skin erythema index of areas A and B was measured a second time.

[0128] Step (4): If the redness worsens or discomfort increases within 20 minutes after applying the soothing cosmetic, the test must be stopped immediately and the number of participants counted.

[0129] Step (5): Calculate the average skin erythema index for each group in regions A and B twice. Volunteers who withdraw from the test do not participate in the calculation of the average skin erythema index.

[0130] Table 2. Average Erythema Index in Area A

[0131]

[0132] Table 3. Average Skin Erythema Index (Area B)

[0133]

[0134] Table 4. Number of people who withdrew from the test due to severe erythema or increased discomfort.

[0135]

[0136] Tables 2 and 3 confirm that the soothing composition of the present invention can exert excellent soothing effects when made into cosmetics, and the synergistic effect between the components is prominent. Table 4 confirms that the soothing composition of the present invention has low sensitivity and irritation when made into cosmetics, does not aggravate existing discomfort, and has high acceptability. In summary, the present invention provides a soothing composition containing trans-4-tert-butylcyclohexanol, which promotes the further application of trans-4-tert-butylcyclohexanol in the field of cosmetics.

[0137] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A soothing composition containing trans-4-tert-butylcyclohexanol, characterized in that: The soothing composition comprises a main agent; the main agent comprises trans-4-tert-butylcyclohexanol, nordihydroguaiacol, and troxerutin.

2. The soothing composition containing trans-4-tert-butylcyclohexanol according to claim 1, characterized in that: The main agent comprises 40-55 parts by weight of trans-4-tert-butylcyclohexanol, 18-26 parts by weight of nordihydroguaiaric acid, and 12-15 parts by weight of troxerutin.

3. The soothing composition containing trans-4-tert-butylcyclohexanol according to claim 1, characterized in that: The soothing composition further includes adjuvants; the weight ratio of the main agent to the adjuvants is 12-18:5-5.

8.

4. The soothing composition containing trans-4-tert-butylcyclohexanol according to claim 3, characterized in that: The auxiliary agent is prepared through the following steps: S1. Take white water lily roots, wash them, dry them and grind them into powder to obtain white water lily root powder. S2. Take the roots of the night-blooming jasmine, wash them, and then dry and grind them into powder to obtain night-blooming jasmine root powder. S3. Add white water lily root powder and eggplant root powder to deionized water, disperse by ultrasonication, add cellulase, perform enzymatic hydrolysis under controlled temperature, inactivate the enzyme, cool, and then centrifuge, filter, and spray dry in sequence.

5. The soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, characterized in that: In step S3, the weight ratio of the white water lily root powder to the eggplant root powder is 26-54:35-48; the weight of the deionized water is 14-22 times the total weight of the white water lily root powder and the eggplant root powder; and the weight of the cellulase is 1-2.7% of the total weight of the white water lily root powder and the eggplant root powder.

6. The soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, characterized in that: In step S3, the cellulase activity is 8000-10000 U / g.

7. The soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, characterized in that: In step S3, the temperature-controlled enzymatic hydrolysis refers to heating to 48-58°C in reflux at a rotation speed of 150-200 r / min, followed by constant temperature treatment for 90-120 min.

8. The soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, characterized in that: In step S3, the cooling refers to condensation and reflux treatment in a water bath at 15-25°C for 5-10 minutes.

9. A soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, characterized in that: In step S3, the centrifugation time is 5-10 min, the rotation speed is 6000-10000 r / min, and the temperature is 25-30℃.

10. A soothing composition containing trans-4-tert-butylcyclohexanol according to claim 4, characterized in that: In step S3, the filtration accuracy is 0.45-1μm.

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