High-stability tooth care paste containing bioactive glass

Abstract

The invention relates to the technical field of medical dental preparations and tooth care compositions with clinical treatment effects, and discloses a high-stability bioactive glass-containing tooth care paste, which comprises a carrier composed of polyethylene glycol-400 and polyethylene glycol-3000 in a mass ratio of 8: 1-12: 1, xylitol, anhydrous sodium citrate and bioactive glass, the xylitol is in a supersaturated precipitation state in the carrier, anhydrous sodium citrate induces in-situ precipitation of the xylitol and constructs a three-dimensional crystallization grid interwoven by dendritic microcrystals with the diameter of 200-500 nm, so that the bioactive glass is physically locked through a steric hindrance effect, and the temperature sensitivity of the rheological property is reduced by utilizing rigid support of the crystallization grid, so that the stability of the bioactive glass is improved. And the grids have water-induced dissolution characteristics, can be instantly dissolved when being in contact with saliva, and completely expose the reaction active surface of the bioactive glass, so that the immediate exchange of ions is ensured, and the problems of poor storage stability of the system and passivation of the active surface are solved.

Description

Technical Field

[0001] This invention belongs to the technical field of medical dental preparations and dental care compositions with clinical therapeutic effects, and particularly relates to a highly stable dental care paste containing bioactive glass. Background Technology

[0002] Currently, dentinal tubules are sealed by inducing the formation of apatite. To prevent this component from failing due to ion exchange in aqueous systems, existing technologies typically select polyols such as polyethylene glycol or glycerol as carriers. To maintain the suspension stability of functional powders in the carrier, physical damping is established by adding polymeric thickeners such as carbomer or cellulose derivatives. However, the solvation film formed by such polymeric components in polyol carriers will coat the surface of bioactive glass particles.

[0003] In the context of brushing teeth, the shielding film hinders the contact between active particles and moisture in saliva, resulting in a lag in ion release rate and weakening the immediate care effect. Increasing the amount of thickener exacerbates the interfacial passivation effect, while decreasing the amount of thickener causes powder sedimentation and agglomeration of the composition under high-temperature transportation conditions. This stability mode driven by exogenous thickening is difficult to balance the conflict between storage stability and immediate release of activity. After the hardware-level stability optimization of the paste matrix and thickening system reached a bottleneck, research turned to software strategies for surface modification of functional particles. For example, Chinese invention patent CN119385842A discloses a surface-modified bioactive glass tooth desensitizer and its preparation method and application. It uses polydopamine to construct a gelatin outer layer on the surface of mesoporous bioactive glass to enhance the adhesion and penetration depth of particles in dentinal tubules. This method of continuous organic polymer coating of active particles exacerbates the interfacial passivation effect, making it difficult for the reactive surface of bioactive glass to be fully exposed at the moment of contact with saliva. The complex surface modification process has not fundamentally solved the problem of component sedimentation caused by viscosity fluctuations in a wide temperature range environment.

[0004] Therefore, the technical problem to be solved by this invention is how to construct a pharmaceutical microlattice framework system that provides steric support in storage and releases pathological repair activity in application without adding exogenous polymer thickeners. Summary of the Invention

[0005] This invention provides a highly stable dental care paste containing bioactive glass, comprising the following components in parts by weight:

[0006] 40 to 80 parts of polyethylene glycol carrier, which is a mixture of polyethylene glycol-400 and polyethylene glycol-3000 in a mass ratio of 8:1 to 12:1; 6 to 14 parts of xylitol as a crystallization monomer; 0.05 to 2 parts of anhydrous sodium citrate as a heterogeneous nucleation site; and 2 to 20 parts of bioactive glass as a care component;

[0007] Tooth care paste in 72 The refractive index was kept constant under certain conditions to characterize the homogeneous molecular-level dissolution of xylitol in the polyethylene glycol carrier; after cooling to 45°C... Up to 50 Within the crystallization temperature window, xylitol is in a supersaturated precipitation state in the polyethylene glycol support, and anhydrous sodium citrate acts as a heterogeneous nucleation center to induce xylitol to precipitate in situ and construct a three-dimensional crystallization grid.

[0008] The three-dimensional crystal mesh consists of a diameter of 200 Up to 500 It is composed of interwoven xylitol dendritic microcrystals; the bioactive glass is physically locked within the gaps in the grid through the steric hindrance effect generated by the three-dimensional crystalline grid, thereby inhibiting the sedimentation and aggregation of the bioactive glass in the system, allowing the tooth care paste to remain within 50... The anti-settlement parameter in the environment is not less than 25. It has 95% of the anti-settling parameters under environmental conditions; the three-dimensional crystalline mesh dissolves upon contact with water to relieve steric hindrance and fully expose the reactive surface of the bioactive glass.

[0009] Preferably, the water content of the polyethylene glycol carrier is less than 0.1%. Bioactive glass is made of calcium sodium phosphate silicate powder, and its... Particle size 3 Up to 10 The precipitation morphology of xylitol in the polyethylene glycol support changed from 1.5 / min to 2.0 The cooling rate was controlled at a rate of / min to lock the average particle size of the dendritic microcrystals at 200. Up to 500 Within the specified range; the surface of the bioactive glass does not have a continuous organic polymer coating.

[0010] Preferably, the anhydrous sodium citrate is an ultrafine powder with a surface energy higher than the spontaneous nucleation energy barrier of xylitol in a polyethylene glycol carrier, so as to induce xylitol to undergo asymmetric heterogeneous nucleation on the surface of anhydrous sodium citrate.

[0011] Preferably, the three-dimensional crystalline mesh, through the rigid support of dendritic microcrystals, reduces the temperature sensitivity of the rheological properties of the tooth care paste, allowing the tooth care paste to remain within a certain temperature range (0°C). Maintain consistent extrusion pressure under environmental conditions.

[0012] Preferably, the distribution concentration of the three-dimensional crystalline mesh in the tooth care paste Satisfy the following formula: ,in, The distribution concentration of the three-dimensional crystalline mesh. For the quality of xylitol input, This represents the crystallization ratio of xylitol on a polyethylene glycol carrier during the cooling process. This refers to the total volume of the dental care paste.

[0013] Preferably, the surface of the bioactive glass does not adsorb polyethylene glycol carrier, so that the bioactive glass generates an instant ion exchange response when in contact with water.

[0014] Preferably, xylitol is obtained by passing 70 Dissolved at the lower molecular level and then subjected to 48 Regenerated microcrystals generated by heterogeneous nucleation.

[0015] Preferably, the dental care paste also includes at least 2 parts of silica abrasive, which is nested within the secondary pores of a three-dimensional crystalline mesh.

[0016] Preferably, the three-dimensional crystalline mesh is a discontinuous physical support mesh that constructs a dynamic equilibrium state with self-supporting characteristics within the tooth care paste.

[0017] Preferably, the directional deposition morphology of xylitol on the surface of anhydrous sodium citrate is 1200 Up to 1500 The shear force field induces the generation to control the spatial distribution density of dendritic microcrystals.

[0018] Compared with existing technologies, the highly stable dental care paste containing bioactive glass of this invention has the following advantages:

[0019] 1. In the glass dental care paste, an asymmetric heterogeneous nucleation mechanism of xylitol and polar inducer in a polyol environment is used to construct a microlattice framework with a three-dimensional physical steric hindrance effect. The spatial nodes generate steric hindrance locking for bioactive glass particles, preventing the active particles from settling or agglomerating under gravity. Compared with the continuous grid constructed by polymer thickeners, the microlattice framework is a discontinuous physical support system. It does not form a continuous organic solvation shielding film on the surface of bioactive glass, eliminating the passivation effect of polymer coating on the active surface, and ensuring that the bioactive glass undergoes instant ion exchange with the water in saliva at the moment of application.

[0020] 2. By utilizing the rigid support of the solid microcrystalline lattice, the temperature sensitivity of the rheological properties of the care cream is reduced. Since the physical stability of the system originates from the nano-scale crystal clusters distributed throughout the system rather than the dynamic viscosity of the carrier liquid, the care cream maintains stable anti-settling properties at high temperatures, inhibiting powder stratification caused by the decrease in polyol viscosity. At the same time, the system does not experience extrusion difficulties due to the hardening of polymer chain segments at low temperatures. This surface lattice formed by phase transition enables the care cream to maintain stable physical properties under wide temperature range transportation and storage conditions, solving the engineering bottleneck of the system being thin in summer and hard in winter.

[0021] 3. A self-collapse release mechanism driven by solubility differences is constructed. Xylitol, as a framework monomer, exists in the carrier in a microcrystalline state and provides static support. Upon contact with oral saliva, the extremely high water solubility of xylitol causes the supporting framework to dissolve and collapse instantaneously. The bioactive glass surface that was originally locked on the framework nodes is then completely exposed. The ion release process does not have the time lag caused by the rearrangement of polymer solvation film, thus achieving a balance between the static rigidity during storage and the dynamic activity during application. This improves the rate and depth of bioactive glass sealing of dentinal tubules, thereby achieving immediate sealing and restorative treatment of sensitive teeth at the pathological level. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the preparation process of the tooth care paste of the present invention and the working mechanism of the microcrystalline mesh;

[0023] Figure 2 This is a flowchart of the physical stability testing and closed-loop quality control process for the dental care paste of this invention. Detailed Implementation

[0024] The technical solutions of the embodiments of this application will be clearly described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of this application are within the scope of protection of this application.

[0025] It should be noted that all directional and positional terms used in this invention, such as: up, down, left, right, front, back, vertical, horizontal, inner, outer, top, low, lateral, longitudinal, center, etc., are only used to explain the relative positional relationship and connection between components in a specific state (as shown in the accompanying drawings). They are only for the convenience of describing this invention and do not require that this invention be constructed and operated in a specific orientation. Therefore, they should not be construed as limiting this invention. In addition, the descriptions of "first," "second," etc., in this invention are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly indicating the number of technical features indicated.

[0026] In the description of this invention, unless otherwise explicitly specified and limited, the terms installation, connection, and linking should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections; they can refer to direct connections or indirect connections through an intermediate medium; they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0027] In the description of this specification, references to the terms "an embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example, and the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0028] This invention relates to a highly stable dental care paste containing bioactive glass, comprising a polyethylene glycol carrier, xylitol as a crystallization monomer, anhydrous sodium citrate as a heterogeneous nucleation site, and bioactive glass as a care component. The polyethylene glycol carrier serves as a continuous liquid phase, providing a storage environment for the bioactive glass. Xylitol precipitates under the induction of anhydrous sodium citrate, forming dendritic microcrystals. These dendritic microcrystals interweave to construct a three-dimensional crystalline network, thereby stably suspending the bioactive glass through steric hindrance. To address the problem of functional powder sedimentation caused by the decrease in viscosity of the polyethylene glycol carrier with increasing temperature, a liquid matrix composed of polyethylene glycol-400 and polyethylene glycol-3000 is constructed, with a mass ratio of polyethylene glycol-400 to polyethylene glycol-3000 of [missing information]. to To provide solubility while maintaining system fluidity, the water content of the polyethylene glycol carrier is lower than [a certain value]. To prevent premature ion exchange in the bioactive glass, polyethylene glycol-400 and polyethylene glycol-3000 are mixed and heated during the preparation process. to Melting produces a low-viscosity continuous phase with controlled molecular weight distribution. To address the solubilization film shielding effect easily generated by conventional thickeners in the system, this invention uses xylitol as a self-responsive supporting unit, with the following components by weight... to Add xylitol to the above molten carrier, and control the stirring speed to [value missing]. to And continue stirring. The process continues until the refractive index of the system reaches a constant level, allowing xylitol to reach a supersaturated reserve state of homogeneous molecular dissolution in the polyethylene glycol carrier. The solubility gradient of xylitol at different temperatures is used to provide a material source for the generation of the microcrystalline lattice.

[0029] To induce xylitol directional crystallization and control crystal size in the system environment, anhydrous sodium citrate was used as a heterogeneous nucleation center. When the system temperature was lowered to [value missing], [further details needed]. to When the crystallization temperature window is within the range, add to Anhydrous sodium citrate powder, by weight, generates heterogeneous nucleation sites. The surface energy of anhydrous sodium citrate is higher than the spontaneous nucleation energy barrier of xylitol in a polyethylene glycol carrier. Due to the extremely high specific surface energy of anhydrous sodium citrate, even at low addition levels (e.g., 0.05 parts), the active sites per unit volume are sufficient to generate induced potential energy. The polar potential energy gradient generated on its surface induces xylitol molecules to preferentially generate asymmetric heterogeneous nucleation on its surface. At this point, increasing the shear speed to... to And maintain constant temperature shearing By utilizing a shear force field to control the spatial distribution density of xylitol microcrystals, in-situ precipitation of these microcrystals can be achieved, forming crystals with a diameter of [missing information]. to Dendritic microcrystal clusters were used to calibrate the heterogeneous nucleation threshold based on surface energy level gradient experiments. An online refractive index monitor was used to capture the supersaturation point of xylitol. (The text abruptly shifts to a seemingly unrelated topic: "If the crystallization induction period...") Deviation from preset curve The programmable temperature control module adjusts the cooling water flow rate and forcibly locks the cooling rate. to Laser particle size analyzers are used for dynamic monitoring of dendrite diameter. Exceeding to Range, synchronously compensated shear speed This enables closed-loop control of the geometric parameters of three-dimensional crystalline meshes.

[0030] To inhibit the sedimentation and aggregation of nursing components during storage, to A certain amount of bioactive glass, in parts by weight, is introduced into the aforementioned system containing microcrystalline clusters. The bioactive glass is calcium sodium phosphate silicate powder. Particle size distribution to By using a vacuum degree of to Under homogeneous mixing conditions, the bioactive glass is trapped and pinned within the gaps of a three-dimensional crystalline network interwoven with dendritic microcrystals. This physical steric hindrance locking mechanism allows the tooth care paste to... The anti-settlement parameter under the environment is not lower than Settlement resistance parameters under environmental conditions Distribution and concentration of three-dimensional crystalline mesh within the tooth care paste Determined according to the following formula: ,in, The distribution concentration of the three-dimensional crystalline mesh, in units of ; The input mass of xylitol is expressed in units of... ; This represents the crystallization ratio of xylitol on a polyethylene glycol carrier during the cooling process. This refers to the total volume of the dental care paste, in units of... By adjusting the above parameters, the rigid support generated by the mesh reduces the temperature sensitivity of the system's rheological properties, thus allowing the tooth care paste to... Maintain consistent extrusion pressure under environmental conditions.

[0031] In application, this three-dimensional crystalline mesh exhibits water-induced dissolution and collapse characteristics. When the toothpaste comes into contact with saliva, xylitol, as a mesh monomer, undergoes instantaneous dissolution, relieving steric hindrance. Since the bioactive glass surface in this design does not have a continuous organic polymer coating, the reactive surface of the bioactive glass is fully exposed to the water environment after the mesh dissolves, resulting in an immediate ion exchange response, thereby increasing the rate of tubule closure. The toothpaste also contains at least... A portion of silica abrasive is embedded within the secondary pores of a three-dimensional crystalline mesh. After in-situ powder bonding of the bioactive glass is completed, the system is maintained at a vacuum level of [missing information]. Continuous homogeneous mixing in a negative pressure environment To eliminate microbubbles generated during mixing and improve the density of the paste, the external circulation cooling device is activated to control the cooling rate of the paste. Wait until the outlet temperature of the ointment reaches When the filling threshold is reached, the prepared tooth care paste is introduced into the filling machine through a closed pipeline for aluminum-plastic composite tube filling. The preparation process adjusts the physical properties and surface structure of the tooth care paste by controlling the temperature and shear parameters of the process stages such as melting, supersaturation introduction, heterogeneous nucleation and steric pinning.

[0032] Example 1: When the ambient temperature is to And the fluctuation range exceeds In high-temperature transportation scenarios, the polyethylene glycol carrier in the toothpaste system loses its ability to support the high-density bioactive glass powder due to a significant decrease in viscosity, causing the powder to settle and stratify under gravity. To address this condition, a mass ratio of [missing information] is selected. Polyethylene glycol-400 and polyethylene glycol-3000 form a liquid matrix, and then... xylitol by weight and Anhydrous sodium citrate, in parts by weight, serves as a heterogeneous nucleation site. The polar potential gradient generated on its surface induces supersaturated, stock-state xylitol in... Directional precipitation within the nucleation temperature window, in Under the action of a high shear force field, xylitol precipitates in situ to form a diameter of to Dendritic microcrystal clusters, interwoven to form a three-dimensional crystalline network, The bioactive glass, by weight, is locked onto the grid nodes through steric hindrance, resulting in a distribution concentration within the three-dimensional crystalline grid. Determined according to the following formula: ,in, The distribution concentration of the three-dimensional crystalline mesh. For the quality of xylitol input, This represents the crystallization ratio of xylitol on a polyethylene glycol carrier during the cooling process. This refers to the total volume of the dental care paste.

[0033] Through the synergistic effect of anhydrous sodium citrate and xylitol, the system is transformed from the traditional method of maintaining suspension by carrier viscosity to a method of providing rigid steric support by a microcrystalline framework. This makes the rheological properties of the toothpaste insensitive to temperature changes, allowing it to be stored continuously under the aforementioned high-temperature environment. After that, the centrifugal separation rate of the dental care paste was less than [amount missing]. Its static energy storage modulus variation is less than When the dental care paste comes into contact with saliva, xylitol, as a grid monomer and highly water-soluble, undergoes instantaneous dissolution, releasing steric hindrance. The reactive surface of the bioactive glass then generates an immediate ion exchange response in an environment free from the shielding of a polymeric solvation film. The dental care paste completes the sealing of the dentinal tubules within the cavity. The anti-settlement parameter under the environment is not lower than Settlement resistance parameters under environmental conditions The system maintains stable physical properties and nursing efficacy.

[0034] Example 2: The experimental platform included a vacuum emulsification system, a precision constant temperature chamber, a centrifuge, and a field emission scanning electron microscope. These were used to acquire data on the centrifugal separation rate of the dental care paste and images of dentinal tubule closure characteristics. The data acquisition process simulated periodic mechanical disturbances. The transport environment was characterized by setting fluctuations in the centrifuge's rotational speed. The input mass of xylitol in the experiment was also considered. Based on the concentration distribution of the three-dimensional crystal mesh Confirmation of the concentration distribution in the three-dimensional crystalline mesh. The spatial distribution density of the three-dimensional crystalline mesh within the paste affects the supporting strength of the system. Based on the decision-making logic in the aforementioned specific implementation method, parallel experiments were conducted using control group 1 (4.0 parts xylitol), test group 1 (6.0 parts xylitol), test group 2 (10.0 parts xylitol), test group 3 (14.0 parts xylitol), and control group 2 (18.0 parts xylitol). All sample groups... Stored in an environmentally friendly environment for 30 days, then separated by centrifugation. Centrifugation The centrifugation stratification rate was measured.

[0035] Table 1: Distribution ratios of different groups in the sample group phenotypic data after 30 days of storage

[0036] Referring to the data in Table 1, compared to sample group 1, the xylitol content was less than 6.0 parts, resulting in insufficient dendritic microcrystals and a lower concentration of the three-dimensional crystalline mesh distribution. Below the critical support threshold, bioactive glass in Under high temperature conditions, gravity sedimentation occurs. Experimental groups 1 to 3 are within the defined range. Experimental group 1 uses 0.05 parts of low-content anhydrous sodium citrate. Although the number of heterogeneous nucleation sites decreases, leading to a slight increase in the centrifugal stratification rate to 0.49%, it is still better than the 0.5% quality control standard. This proves that the high-energy nucleating agent can still induce in-situ crystallization of xylitol and construct an effective network structure under trace conditions. When the xylitol content increases to 18.0 parts, the precipitated dendritic microcrystals become excessively interwoven, resulting in an excessively strong steric hindrance effect from the three-dimensional crystalline network, causing the paste to lose its rheological properties. The component range defined in this invention is the optimal working window that balances storage stability and application compliance. To determine the effect of the mass ratio of polyethylene glycol-400 to polyethylene glycol-3000 in the polyethylene glycol carrier on the initial stability of the system, a set of comparative experiments was conducted. When the mass ratio was set to... At that time, the system was The dynamic viscosity in the molten state exceeds a set threshold, resulting in... Under stirring conditions, the kinetic energy transfer efficiency decreases, and xylitol cannot achieve a homogeneous molecular-level distribution within the predetermined time, resulting in uneven distribution of subsequently precipitated crystallites; while when the mass ratio is set to... At that time, the cohesive force of the liquid continuous phase is insufficient, and it cannot effectively support the precipitated dendritic microcrystals during the cooling process, leading to local collapse of the three-dimensional crystalline network and causing powder agglomeration; experimental data show that, to Within a certain mass ratio range, the rheological properties generated by the polyethylene glycol carrier can ensure... The shear energy induces asymmetric heterogeneous nucleation, and in Under the given environment, the interaction forces between the mesh framework and the carrier matrix are in equilibrium, and the deviation of the anti-settlement parameters of the resulting product from the initial state remains within a certain range. Within; to further verify the water-induced solubility characteristics of the three-dimensional crystalline mesh, simulated saliva was used to treat experimental group 2 and the group using... Comparative sample group 3, using sodium carboxymethyl cellulose as a thickener, underwent a flushing test. The tubule sealing rate was recorded using scanning electron microscopy. During the test, [the following was applied]. At constant pressure, record respectively and Closed data at that time.

[0037] Table 2: Comparison of tubule sealing rates of different thickening systems under simulated salivary conditions

[0038]

[0039] Referring to the data in Table 2, in contrast sample group 3, sodium carboxymethyl cellulose formed a solvation film shielding on the surface of the bioactive glass, resulting in a slow ion exchange response. In experimental group 2, the water solubility of xylitol caused the three-dimensional crystalline network to dissolve and collapse upon contact with saliva, releasing the sterically blocked reactive surface of the bioactive glass and exposing it. Calcium and phosphorus ion deposition occurs within the dentinal tubules to seal them. Experimental results show that this invention, through the regulation of the physical phase of the system, enables the system's anti-settling parameters to remain within a certain range. Maintaining in the environment Status above.

[0040] Example 3: This example combines Figures 1 to 2 The description of a highly stable dental care paste containing bioactive glass is as follows: Figure 1 As shown, the formulation control center sends a temperature command of 72℃ and a PEG ratio control signal of 8:1 to 12:1 to the carrier homogenization module, a shear parameter of 1500 r / min and a cooling rate of 1.5 to 2.0℃ / min to the heterogeneous nucleation and crystallization module, and a vacuum control signal of -0.09 MPa to the steric hindrance locking assembly module. The carrier homogenization module outputs constant refractive index data and forms an A1 molecular-level homogeneous state. The generated supersaturated reserve state flow enters the heterogeneous nucleation and crystallization module, which outputs data on crystallite size of 200 to 500 nm and forms an A2 three-dimensional crystalline grid. The dendritic crystal flow enters the steric hindrance locking assembly module and outputs data on anti-settling parameter >95% and forms an A3 stable finished product paste. The finished product application flow enters the water-induced response release stage, triggering a dissolution and collapse response and feedback of ion exchange data Ca / P through saliva water input in the oral clinical environment.

[0041] like Figure 2As shown, the production system collects and sends samples for testing. The samples are centrifuged by the testing equipment at 3000 r / min for 30 min to determine the centrifugation stratification rate, and the data is transmitted to the quality judgment module for comparison with the standard: the stratification rate is less than 0.5%. At the same time, the testing equipment stores the samples in a 50℃ environment for 30 days and then measures the anti-settling parameters. The quality judgment module judges the samples according to the standard: not less than 95% at 25℃. The testing equipment performs a simulated saliva flushing test on the samples and records the tubule closure rate under a constant pressure of 150g, obtaining 30s and 60s closure data. Finally, the quality judgment module feeds back the quality results to the production system, and the production system adjusts the process parameters accordingly.

[0042] Example 4: When the ambient temperature is to Under dynamic cyclic conditions, the viscosity-thermal dilution effect of the polyethylene glycol carrier causes gravitational settling stress in the bioactive glass; a mass ratio of [missing information] was selected. A liquid matrix was constructed using polyethylene glycol-400 and polyethylene glycol-3000, and the initial water content was controlled to be below [value missing] using a coulometric moisture analyzer. The system is heated to [temperature] by the heating unit. make The xylitol by weight undergoes homogeneous dissolution. The programmed temperature control mode is activated, and the cooling rate is set to [value missing]. to The supersaturation level is accumulated by utilizing the solubility gradient of xylitol in the polyethylene glycol carrier within a certain range. When the system is cooled to... When, add Anhydrous sodium citrate powder in parts by weight and instantaneously reducing the shear speed from Upgraded to At this point, the polar potential energy gradient generated on the surface of the anhydrous sodium citrate particles reduces the activation energy required for xylitol to generate crystal nuclei. The process induces asymmetric heteronucleation of supersaturated xylitol on the surface of anhydrous sodium citrate particles; this asymmetric heteronucleation process inhibits crystal growth along a single axis, resulting in crystals with a diameter of [missing information]. to Dendritic microcrystal clusters.

[0043] Dendritic microcrystal clusters self-organize and interweave under a shear force field to form a three-dimensional crystalline mesh with self-supporting characteristics. Bioactive glass by weight generates steric locking force ; steric locking force Satisfy the following formula: ,in, The steric locking force exerted by the three-dimensional crystalline mesh on the bioactive glass is expressed in units of . ; This is the physical steric hindrance coefficient, and its value is positively correlated with the aspect ratio of the dendritic microcrystals. The distribution concentration of the three-dimensional crystalline mesh, in units of In the process After several temperature cycles, the fluctuation rate of the bulk density of the components at the bottom of the dental care paste was lower than that of... This indicates that the in-situ generated physical isolation field provides compensatory support modulus when the viscosity of the polyethylene glycol carrier fluctuates; when the dental care paste comes into contact with the saliva environment, the solubility entropy change generated by xylitol drives the three-dimensional crystalline mesh in... The internal collapse releases steric hindrance, allowing the bioactive glass to release calcium and phosphorus ions in an environment without the shielding of a polymer solvation film. Deposits are generated inside to seal the dentinal tubules. To further enhance the ability to remove dental stains, an additional 2 parts of silica abrasive were introduced into the system. Tests showed that even with the increased abrasive content, the secondary pores of the three-dimensional crystalline mesh could still effectively accommodate these particles. The anti-settling parameter of the paste at 50°C did not decrease significantly, demonstrating the compatibility of the mesh structure with high-load solid phases.

[0044] Example 5: In a production environment where the viscosity reference of the polyethylene glycol carrier shifted due to changing different batches of the carrier, the cooling rate during the xylitol crystallization stage was calibrated based on the rheological parameters of the polyethylene glycol carrier at different temperatures fed back by the measuring equipment. When the dynamic viscosity deviates from the set value, the cooling rate is controlled by adjusting the output power of the programmable temperature control module. to By matching the rate of supersaturation accumulation of xylitol molecules with the induction efficiency of heterogeneous nucleation sites, a correlation was established between the batch characteristics of raw materials and the morphology of the three-dimensional crystal mesh. This eliminated the fluctuations in lattice framework strength caused by differences in the molecular weight distribution of the carrier, and based on the distribution concentration of the three-dimensional crystal mesh... The evaluation model monitors the physical stability of the toothpaste by calculating the actual crystallization ratio of xylitol in the polyethylene glycol carrier. Substitute the distribution concentration The calculation formula is as follows: ,in, The distribution concentration of the three-dimensional crystalline mesh, in units of ; The mass of xylitol is expressed in units of... ; The crystallization ratio of xylitol in the polyethylene glycol carrier is a dimensionless parameter. This refers to the total volume of the dental care paste, in units of... .

[0045] If the calculated distribution concentration If the product deviates from the set range, the nucleation density of dendritic microcrystals is maintained by increasing the proportion of anhydrous sodium citrate, thus ensuring the produced tooth care paste... The centrifugal stratification rate under the environmental conditions is lower than At this point, the dental care paste generates an immediate ion release response upon contact with saliva. An anti-sedimentation evaluation system based on the Stokes modified model is established, and a rheometer is used to measure... Dynamic viscosity ,formula Used to calculate the concentration of the grid distribution, if Below the critical support threshold Automatically adjust the proportion of anhydrous sodium citrate Increase nucleation density to compensate for potential resistance caused by batch viscosity fluctuations. For batches with anhydrous sodium citrate added in the low range of 0.05 to 0.2 parts, the system will automatically compensate the shear speed to 1550 r / min to make up for the difference in the number of nucleation sites with higher shear energy, ensuring the density of crystal nucleation. The centrifugal stability analyzer is used to feed back the sedimentation vector, and the deviation signal is fed back to the feeding actuator to achieve a dynamic balance between storage stability and ion release activity.

[0046] Example 6: In a large-scale production scenario involving the switching of different batches of bioactive glass raw materials, to address the fluctuations in ion release rate caused by differences in powder specific surface area, a pre-activity calibration procedure was used to correct the process ratio. A bioactive glass sample to be fed was selected and dispersed in a simulated saliva buffer solution, and a precision ion electrode was used to measure the ion release rate. calcium and phosphorus ion concentration at time Based on calcium and phosphorus ion concentration Concentration distribution with three-dimensional crystal mesh The mapping relationship between them determines the required xylitol input mass for the current batch. The steric hindrance locking force generated by the three-dimensional crystalline mesh can block the penetration of water into the carrier while maintaining the dissolution and collapse properties of the tooth care paste after contact with saliva. The mesh structure density can be adjusted by quantifying the ion release potential energy of the raw materials, thus avoiding physical deviations caused by inconsistent tubule sealing efficiency due to fluctuations in mineralization activity.

[0047] When the production system transitions from a laboratory unit to a large-scale unit and encounters heat transfer lag conditions, the flow rate of the cooling circulating water is adjusted using a programmable temperature control unit. By monitoring the temperature gradient inside the reactor, the cooling rate is maintained at a certain level. to The production speed is determined between these parameters, based on the principle of constant blade tip speed. Production speed The calculation formula is as follows: ,in, For production speed, the unit is... ; To calibrate the rotational speed for the experiment, the value was set to... ; The diameter of the experimental unit's blades, in units of ; The diameter of the turbine blades is given in units of 1. This method of determining rotational speed maintains the consistency of shear energy density, inducing xylitol to precipitate on the surface of anhydrous sodium citrate, forming a precipitate with a diameter of [missing information]. to Dendritic microcrystal clusters, thus producing a centrifugation stratification rate lower than Furthermore, the tooth care paste has stable physicochemical properties and meets pharmaceutical standards and dental formulation standards.

[0048] The embodiments of this application have been described above with reference to the accompanying drawings. Unless otherwise specified, the embodiments and features in the embodiments of this application can be combined with each other. This application is not limited to the specific embodiments described above. The specific embodiments described above are merely illustrative and not restrictive. Those skilled in the art can make many other forms under the guidance of this application without departing from the spirit of this application and the scope of protection of this invention, and all of these forms are within the protection scope of this application.

Claims

1. A highly stable dental care paste containing bioactive glass, characterized in that, Includes the following components by weight: 40 to 80 parts of polyethylene glycol carrier, which is a mixture of polyethylene glycol-400 and polyethylene glycol-3000 in a mass ratio of 8:1 to 12:1; 6 to 14 parts of xylitol as crystallization monomer; and 0.05 to 2 parts of anhydrous sodium citrate as heterogeneous nucleation sites. And 2 to 20 parts of bioactive glass as a nursing component; The refractive index of the dental care paste remained constant at 72°C, indicating that xylitol achieved a homogeneous molecular-level dissolution in the polyethylene glycol carrier; upon cooling to 45°C... Up to 50 Within the crystallization temperature window, xylitol is in a supersaturated precipitation state in the polyethylene glycol support, and anhydrous sodium citrate acts as a heterogeneous nucleation center to induce xylitol to precipitate in situ and construct a three-dimensional crystallization grid. The three-dimensional crystal mesh consists of a diameter of 200 Up to 500 It is composed of interwoven xylitol dendritic microcrystals; the bioactive glass is physically locked within the gaps in the grid through the steric hindrance effect generated by the three-dimensional crystalline grid, thereby inhibiting the sedimentation and aggregation of the bioactive glass in the system, allowing the tooth care paste to remain within 50... The anti-settlement parameter in the environment is not less than 25. It has 95% of the anti-settling parameters under environmental conditions; the three-dimensional crystalline mesh dissolves upon contact with water to relieve steric hindrance and fully expose the reactive surface of the bioactive glass.

2. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, The water content of the polyethylene glycol carrier is less than 0.1%. Bioactive glass is made of calcium sodium phosphate silicate powder, and its... Particle size 3 Up to 10 The precipitation morphology of xylitol in the polyethylene glycol support changed from 1.5 / min to 2.0 The cooling rate was controlled at a rate of / min to lock the average particle size of the dendritic microcrystals at 200. Up to 500 Within the specified range; the surface of the bioactive glass does not have a continuous organic polymer coating.

3. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, Anhydrous sodium citrate is an ultrafine powder with a surface energy higher than the spontaneous nucleation energy barrier of xylitol in a polyethylene glycol carrier, thereby inducing xylitol to undergo asymmetric heterogeneous nucleation on the surface of anhydrous sodium citrate.

4. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, The three-dimensional crystalline mesh, through the rigid support of dendritic microcrystals, lowers the temperature sensitivity of the rheological properties of the tooth care paste, allowing the tooth care paste to remain within a 0°C range. Maintain consistent extrusion pressure under environmental conditions.

5. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, Distribution and concentration of three-dimensional crystalline mesh in dental care paste Satisfy the following formula: ,in, The distribution concentration of the three-dimensional crystalline mesh. For the quality of xylitol input, This represents the crystallization ratio of xylitol on a polyethylene glycol carrier during the cooling process. This refers to the total volume of the dental care paste.

6. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, The surface of the bioactive glass does not adsorb polyethylene glycol carrier, which enables the bioactive glass to generate an instant ion exchange response when it comes into contact with water.

7. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, Xylitol is 70% Dissolved at the lower molecular level and then subjected to 48 Regenerated microcrystals generated by heterogeneous nucleation.

8. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, The dental care paste also includes at least 2 parts of silica abrasive, which is nested within the secondary pores of a three-dimensional crystalline mesh.

9. The highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, The three-dimensional crystalline mesh is a discontinuous physical support mesh that constructs a dynamic equilibrium state with self-supporting characteristics within the tooth care paste.

10. A highly stable dental care paste containing bioactive glass according to claim 1, characterized in that, The directional deposition morphology of xylitol on anhydrous sodium citrate surface varies from 1200. Up to 1500 The shear force field induces the generation to control the spatial distribution density of dendritic microcrystals.

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