Preparation method of oral anti-wrinkle beauty product fused by carbon monoxide precursor and apple polyphenol
By preparing an oral anti-wrinkle beauty product containing apple polyphenols and carboxyheme, the problem of the lack of significant anti-wrinkle beauty effects in existing technologies has been solved, achieving efficient, stable anti-wrinkle effects and convenience.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHONGDITAIKE (NANJING) BIOTECHNOLOGY CO LTD
- Filing Date
- 2024-11-11
- Publication Date
- 2026-05-12
AI Technical Summary
In the current technology, no cosmetic products have been developed that combine carbon monoxide precursors with apple polyphenols, and there is a lack of oral products with significant anti-wrinkle and cosmetic effects.
An oral anti-wrinkle beauty product in tablet form is prepared by mixing and micronizing ingredients such as apple polyphenols and carboxyheme, combined with microencapsulation technology and liposome encapsulation.
It improves the stability and bioavailability of apple polyphenols and carboxyheme, enhances antioxidant capacity, promotes skin microcirculation and cell vitality, provides significant anti-wrinkle effects, and improves product convenience.
Smart Images
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Abstract
Description
TECHNICAL FIELD
[0001] The present application relates to the field of cosmetic products, in particular, to a preparation method of an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenol. BACKGROUND
[0002] With the rise of healthy beauty concept, consumers' demand for natural and efficient cosmetic products is growing.
[0003] Apple polyphenol, as a natural antioxidant, has become a popular ingredient in cosmetic products due to its strong antioxidant properties, free radical scavenging, anti-aging, and whitening effects. Carbon monoxide precursors, such as carboxyhemoglobin, have also been found to promote skin microcirculation and enhance cell vitality.
[0004] However, there is a blank in the preparation of cosmetic products fused with both carbon monoxide precursors and apple polyphenol. Therefore, the present application proposes a preparation method of an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenol, which aims to develop an oral product with significant anti-wrinkle and cosmetic effects. SUMMARY
[0005] To overcome the above problems, the present application aims to propose a preparation method of an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenol, which aims to solve the problem that model optimization and conflict detection mainly consider the spatial position of components, ignoring the parameters and attributes of components, which may lead to incomplete detection and failure to discover some potential problems.
[0006] To this end, the specific technical solutions adopted by the present application are as follows:
[0007] According to one aspect of the present application, an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenol is provided, which is composed of the following materials: apple polyphenol 20%, carboxyhemoglobin (CO precursor) 5%, grape seed extract 10%, vitamin C 5%, natural vitamin E 3%, sodium hyaluronate 2%, malt dextrin 40%, magnesium stearate 1%, water-dispersible cellulose 10%, and excipients 10%.
[0008] Optionally, the purity of the apple polyphenol is ≥ 99%, and the purity of the grape seed extract is ≥ 95%.
[0009] Optionally, the excipients include any one or more of sweeteners, sour agents, and fragrances, with the allocation of sweeteners ≥ fragrances ≥ sour agents.
[0010] According to another aspect of the present application, a preparation method of an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenol is also provided, which specifically includes the following steps:
[0011] S1. Prepare the appropriate materials according to the proportions and set them aside for use. At the same time, micronize the apple polyphenols.
[0012] S2. First, add maltodextrin and water-dispersible cellulose to the mixer for initial mixing, then add apple polyphenols, carboxyheme, grape seed extract, vitamin C and natural vitamin E, sodium hyaluronate, magnesium stearate and other excipients and stir at high speed.
[0013] S3. Use microencapsulation technology to encapsulate easily oxidized or volatile components, including vitamin C and carboxyheme;
[0014] S4. Feed the well-mixed materials into a tablet press, press them into tablets through a mold, and finally inspect and package them.
[0015] The specific process for micronizing apple polyphenols is as follows:
[0016] S11. Fresh, disease-free, and moderately ripe apples are used as raw materials to ensure the quality and activity of apple polyphenols.
[0017] S12. After crushing the apples, use ultrasound-assisted ethanol extraction. The cavitation and mechanical effects of ultrasound accelerate the rupture of apple cell walls to obtain apple extract.
[0018] S13. After filtration and concentration, the extract is subjected to vacuum freeze-drying technology to remove the solvent, resulting in apple polyphenol dry powder. Subsequently, it is micronized by air jet milling or ball milling to achieve a particle size of nanoscale, thus obtaining apple polyphenol micro powder.
[0019] In step S2, carboxyheme needs to be screened and stabilized before being added. The specific processing steps are as follows:
[0020] S21. Pharmaceutical-grade carboxyheme is selected and its quality is tested by high-performance liquid chromatography (HPLC) to remove impurities and unqualified products.
[0021] S22. To prevent the oxidation or degradation of carboxyheme during the preparation process, cyclodextrin inclusion technology is used to mix carboxyheme and β-cyclodextrin in a certain proportion to carry out the inclusion reaction and form a stable inclusion complex.
[0022] After the carboxyheme forms a stable inclusion complex, it is further encapsulated by liposomes, which are composed of lipid components such as phospholipids and cholesterol.
[0023] Compared with the prior art, this application has the following beneficial effects:
[0024] 1. The use of ultrasonic-assisted extraction and vacuum drying technology improves the extraction efficiency and purity of apple polyphenols.
[0025] 2. Carboxyheme and β-cyclodextrin are mixed in a certain proportion to carry out an inclusion reaction to form a stable inclusion complex, which prevents the carboxyheme from being oxidized or degraded during the preparation process. The inclusion complex is then encapsulated again by liposomes, which significantly improves the stability and bioavailability of the active ingredient of carboxyheme.
[0026] 3. By micronizing apple polyphenols and using microencapsulation technology, the solubility and stability of apple polyphenols can be improved, thereby enhancing their bioavailability.
[0027] 4. The synergistic effect of apple polyphenols and carboxyheme not only enhances the product's antioxidant capacity but also promotes skin microcirculation and cell vitality, thereby improving its anti-wrinkle and beautifying effects.
[0028] 5. The tablet form makes it easy to carry and take, improving the convenience for consumers.
[0029] In summary, this preparation method, through extraction, mixing, coating, and tableting, has successfully developed a highly efficient, stable, and safe oral anti-wrinkle cosmetic product. Detailed Implementation
[0030] To enable those skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application are clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present application.
[0031] According to embodiments of the present invention, a method for preparing an oral anti-wrinkle cosmetic product comprising a carbon monoxide precursor and apple polyphenols is provided.
[0032] According to one embodiment of the present invention, an oral anti-wrinkle cosmetic product is provided, which is a fusion of carbon monoxide precursor and apple polyphenols. The product is composed of the following materials: 20% apple polyphenols, 5% carboxyheme (CO precursor), 10% grape seed extract, 5% vitamin C, 3% natural vitamin E, 2% sodium hyaluronate, 40% maltodextrin, 1% magnesium stearate, 10% water-dispersible cellulose, and 10% excipients.
[0033] The apple polyphenols have a purity of ≥99%, and the grape seed extract has a purity of ≥95%.
[0034] The excipients include any one or more of sweeteners, acidulants, and flavorings, with the following proportions: sweeteners ≥ flavorings ≥ acidulants.
[0035] The specific materials are shown in Table 1:
[0036] Table 1: Purity and Proportion of Each Material
[0037]
[0038]
[0039] A method for preparing an oral anti-wrinkle cosmetic product incorporating a carbon monoxide precursor and apple polyphenols, the method specifically comprising the following steps:
[0040] S1. Prepare the appropriate materials according to the proportions and set them aside for use. At the same time, micronize the apple polyphenols.
[0041] S2. First, add maltodextrin and water-dispersible cellulose to the mixer for initial mixing, then add apple polyphenols, carboxyheme, grape seed extract, vitamin C and natural vitamin E, sodium hyaluronate, magnesium stearate and other excipients and stir at high speed.
[0042] S3. Use microencapsulation technology to encapsulate easily oxidized or volatile components, including vitamin C and carboxyheme;
[0043] S4. Feed the well-mixed materials into a tablet press, press them into tablets through a mold, and finally inspect and package them.
[0044] The specific process for micronizing apple polyphenols is as follows:
[0045] S11. Fresh, disease-free, and moderately ripe apples are used as raw materials to ensure the quality and activity of apple polyphenols.
[0046] S12. After crushing the apples, use ultrasound-assisted ethanol extraction. The cavitation and mechanical effects of ultrasound accelerate the rupture of apple cell walls to obtain apple extract.
[0047] S13. After filtration and concentration, the extract is subjected to vacuum freeze-drying technology to remove the solvent, resulting in apple polyphenol dry powder. Subsequently, it is micronized by air jet milling or ball milling to achieve a particle size of nanoscale, thus obtaining apple polyphenol micro powder.
[0048] In step S2, carboxyheme needs to be screened and stabilized before being added. The specific processing steps are as follows:
[0049] S21. Pharmaceutical-grade carboxyheme is selected and its quality is tested by high-performance liquid chromatography (HPLC) to remove impurities and unqualified products.
[0050] S22. To prevent the oxidation or degradation of carboxyheme during the preparation process, cyclodextrin inclusion technology is used to mix carboxyheme and β-cyclodextrin in a certain proportion to carry out the inclusion reaction and form a stable inclusion complex.
[0051] After the carboxyheme forms a stable inclusion complex, it is further encapsulated by liposomes, which are composed of lipid components such as phospholipids and cholesterol.
[0052] Although the present invention has been disclosed above with reference to preferred embodiments, the embodiments are merely examples for illustrative purposes and are not intended to limit the present invention. Those skilled in the art can make various modifications and refinements without departing from the spirit and scope of the present invention. The scope of protection claimed by the present invention should be determined by the claims.
Claims
1. An oral anti-wrinkle cosmetic product incorporating a carbon monoxide precursor and apple polyphenols, characterized in that, This product is composed of the following ingredients: 20% apple polyphenols, 5% carboxyheme (CO precursor), 10% grape seed extract, 5% vitamin C, 3% natural vitamin E, 2% sodium hyaluronate, 40% maltodextrin, 1% magnesium stearate, 10% water-dispersible cellulose, and 10% excipients.
2. The oral anti-wrinkle cosmetic product comprising a carbon monoxide precursor and apple polyphenols according to claim 1, characterized in that, The apple polyphenols have a purity of ≥99%, and the grape seed extract has a purity of ≥95%.
3. The oral anti-wrinkle cosmetic product comprising a carbon monoxide precursor and apple polyphenols according to claim 1, characterized in that, The excipients include any one or more of sweeteners, acidulants, and flavorings, in the following proportions: sweeteners ≥ flavorings ≥ acidulants.
4. A method for preparing an oral anti-wrinkle cosmetic product comprising a carbon monoxide precursor and apple polyphenols according to any one of claims 1-3, characterized in that, The preparation method specifically includes the following steps: S1. Prepare the appropriate materials according to the proportions and set them aside for use. At the same time, micronize the apple polyphenols. S2. First, add maltodextrin and water-dispersible cellulose to the mixer for initial mixing, then add apple polyphenols, carboxyheme, grape seed extract, vitamin C and natural vitamin E, sodium hyaluronate, magnesium stearate and other excipients and stir at high speed. S3. Use microencapsulation technology to encapsulate easily oxidized or volatile components, including vitamin C and carboxyheme; S4. Feed the well-mixed materials into a tablet press, press them into tablets through a mold, and finally inspect and package them.
5. The method for preparing an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenols according to claim 4, characterized in that, The specific process for micronizing apple polyphenols is as follows: S11. Fresh, disease-free, and moderately ripe apples are used as raw materials to ensure the quality and activity of apple polyphenols. S12. After crushing the apples, use ultrasound-assisted ethanol extraction. The cavitation and mechanical effects of ultrasound accelerate the rupture of apple cell walls to obtain apple extract. S13. After filtration and concentration, the extract is subjected to vacuum freeze-drying technology to remove the solvent, resulting in apple polyphenol dry powder. Subsequently, it is micronized by air jet milling or ball milling to achieve a particle size of nanoscale, thus obtaining apple polyphenol micro powder.
6. The method for preparing an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenols according to claim 1, characterized in that, In step S2, carboxyheme needs to be screened and stabilized before being added. The specific processing steps are as follows: S21. Pharmaceutical-grade carboxyheme is selected and its quality is tested by high-performance liquid chromatography (HPLC) to remove impurities and unqualified products. S22. To prevent the oxidation or degradation of carboxyheme during the preparation process, cyclodextrin inclusion technology is used to mix carboxyheme and β-cyclodextrin in a certain proportion to carry out the inclusion reaction and form a stable inclusion complex.
7. The method for preparing an oral anti-wrinkle cosmetic product fused with a carbon monoxide precursor and apple polyphenols according to claim 6, characterized in that, After the carboxyheme forms a stable inclusion complex, it is further encapsulated by liposomes, which are composed of lipid components such as phospholipids and cholesterol.