Traditional Chinese medicine composition for preventing and treating avian influenza disease as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating avian influenza as well as a preparation method and application thereof. The traditional Chinese medicine composition contains active ingredients, and the active ingredients are prepared from trollius chinensis bunge, radix isatidis, selfheal, houttuynia cordata, cyrtomium fortunei, lysimachia christinae hance, astragalus membranaceus and liquorice. All the medicines are combined to achieve a synergistic effect and have the effects of clearing away heat and toxic materials, ventilating the lung, purging heat and relieving cough and asthma. The composition can be effectively used for preventing and treating avian influenza diseases, and has the advantages of wide raw material source, safety, environmental protection, simple preparation process, low production cost and the like.

Description

Technical Field

[0001] This invention relates to a traditional Chinese medicine composition, and more particularly to a traditional Chinese medicine composition for the prevention and treatment of avian influenza, its preparation method, and its application. Background Technology

[0002] Avian influenza is a viral influenza affecting birds, caused by type A influenza viruses. It is an infectious disease that causes a range of symptoms from respiratory illness to severe systemic septicemia. It generally occurs primarily in spring and winter. The avian influenza virus can attack healthy cells and multiplies in the digestive tract of birds. The main sources of infection are poultry, wild birds, or pigs that are infected with or carrying the avian influenza virus. Chickens and turkeys are most susceptible; chickens and turkeys of all ages can be infected, become ill, and die, with high morbidity and mortality rates. Waterfowl such as ducks and geese are also relatively susceptible to infection, and can be carriers or latently infected. The mortality rate is high in waterfowl such as ducklings and goslings. Different breeds of poultry have different probabilities of contracting avian influenza, and currently, no correlation has been found between the sex of birds and the occurrence of highly pathogenic avian influenza.

[0003] The spread of highly pathogenic avian influenza among poultry flocks relies primarily on horizontal transmission, such as through air, feed, feces, and drinking water, while evidence of vertical transmission is scarce. Avian influenza viruses can be transmitted through the respiratory tract, feces, and ocular and nasal secretions of infected birds, leading to infection via the digestive and respiratory tracts. The World Health Organization considers the feces of infected birds to be the main route of transmission, while some experts also believe that migratory birds' migration is another possible route. Avian influenza viruses are more likely to survive and spread in cold, humid environments, while their survival and transmissibility are relatively weaker in warm, dry, and sunny conditions. Therefore, outbreaks are more likely to occur in cold, humid regions and seasons (such as autumn, winter, and spring).

[0004] Highly pathogenic avian influenza viruses are primarily transmitted through the air. They bind to receptors on the surface of respiratory mucosal epithelial cells via hemagglutinin (H) on the viral surface, adhering to these cells. They then utilize neuraminidase (N) on the viral surface to act on... nucleoprotein The receptors on the virus allow it to bind to nucleoproteins in epithelial cells, forming soluble RNA antigens within the nucleus. These antigens then leak into the cytoplasm, replicating progeny viruses. Through neuraminic acid action, the viruses are expelled from the epithelial cells via budding. A single replication cycle takes 4–6 hours. The expelled viruses then spread to nearby cells, producing… Inflammatory response Clinically, it presents with systemic toxemia-like reactions such as muscle pain, fever, and leukopenia.

[0005] Influenza viruses primarily invade the epithelial cells of the respiratory mucosa, causing epithelial cell proliferation, local mucosal congestion, necrosis, edema, and superficial ulcers. Catarrh Lesions. After 4-5 days, the lesions in the basal cell layer can extend to... bronchus , bronchiolesAlveoli and peribronchial tissues, causing mucous membrane Edema, congestion, and lymphocytic infiltration, accompanied by microvascular embolism, necrosis, small aneurysm formation, and hemorrhage, trigger a systemic toxemia-like reaction. A small number of severe cases are progressive. pneumonia In addition to inflammatory changes in the bronchioles, there may be alveolar wall congestion and edema, fibrosis, etc. protein Exudation, mononuclear cell infiltration and hyaline membrane formation, as well as pulmonary hemorrhage, can cause a number of complications.

[0006] Currently, most vaccines for treating avian influenza, both domestically and internationally, are not very effective, and there are no specific drugs available for treating avian influenza. Therefore, controlling the transmission routes is crucial, but enhancing the immunity of susceptible poultry flocks and raising the infection threshold of susceptible animals are even more important measures for controlling avian influenza. Summary of the Invention

[0007] To address the aforementioned technical problems, this invention provides a traditional Chinese medicine composition for the prevention and treatment of avian influenza.

[0008] The traditional Chinese medicine composition contains active ingredients, which are made from golden lotus, isatis root, prunella vulgaris, houttuynia cordata, dryopteris crassirhizoma, cowpea, astragalus membranaceus, and licorice.

[0009] Furthermore, the active ingredients, by weight, are made from 60-100 parts of golden lotus, 20-80 parts of isatis root, 20-60 parts of prunella vulgaris, 30-80 parts of houttuynia cordata, 20-50 parts of dryopteris crassirhizoma, 60-120 parts of cowpea, 30-50 parts of astragalus membranaceus, and 10-30 parts of licorice.

[0010] Furthermore, the active ingredients, by weight, are made from 70-90 parts of golden lotus, 40-60 parts of isatis root, 30-50 parts of prunella vulgaris, 40-70 parts of houttuynia cordata, 30-45 parts of dryopteris crassirhizoma, 80-100 parts of cowpea, 35-45 parts of astragalus membranaceus, and 15-25 parts of licorice.

[0011] Furthermore, the active ingredients, by weight, are made from 80 parts of golden lotus, 50 parts of isatis root, 40 parts of prunella vulgaris, 60 parts of houttuynia cordata, 36 parts of dryopteris crassirhizoma, 90 parts of cowpea, 40 parts of astragalus membranaceus, and 20 parts of licorice.

[0012] Another object of the present invention is to provide a method for preparing a traditional Chinese medicine composition for preventing and treating avian influenza, comprising the following steps:

[0013] (1) Weigh each drug raw material according to the weight ratio;

[0014] (2) The weighed raw materials are crushed and sieved, or the weighed raw materials are extracted and concentrated by water or alcohol, and then pharmaceutically usable excipients or auxiliary ingredients are added to prepare the product.

[0015] The dosage form of the traditional Chinese medicine composition for preventing and treating avian influenza prepared by the above preparation method can be: powder, premix, granule, or oral liquid.

[0016] Furthermore, the traditional Chinese medicine composition powder for preventing and treating avian influenza prepared by the aforementioned method should have a particle size of less than 50 micrometers.

[0017] The present invention also provides the application of the aforementioned traditional Chinese medicine composition in the prevention and treatment of avian influenza.

[0018] Specifically, the traditional Chinese medicine composition is prepared into a drug for preventing and treating avian influenza.

[0019] Furthermore, the present invention also provides a feed containing the aforementioned traditional Chinese medicine composition.

[0020] The advantages and beneficial effects of the drug of this invention are as follows:

[0021] The drug components and their dosages in the herbal composition of this invention are derived from the principles of syndrome differentiation and treatment in traditional Chinese veterinary medicine, and have been repeatedly verified through numerous clinical trials. The prescription of this invention is a precise prescription derived from the pathogenesis and clinical symptoms of avian influenza, guided by the principles of syndrome differentiation and treatment in traditional Chinese medicine, and has been validated through extensive clinical trials. It has excellent preventive and therapeutic effects against avian influenza.

[0022] This invention utilizes the holistic concept and dialectical treatment theory of traditional Chinese medicine to effectively prevent and treat avian influenza. In traditional Chinese medicine, avian influenza is considered an epidemic disease, caused by internal heat and external wind-cold. Treatment primarily focuses on releasing exterior cold and clearing internal heat. Traditional Chinese medicine classifies avian influenza into four different syndrome types: First, the syndrome of toxic evil invading the lungs, where the main pathogenesis is the invasion of toxic evil into the lung's defensive qi, leading to impaired lung function. Symptoms include fever, chills, and cough. Treatment focuses on clearing heat and detoxifying, and expelling pathogens from the lungs. Second, the syndrome of toxic evil invading the lungs and stomach, where the main pathogenesis is the invasion of toxic evil into the lungs and stomach, leading to impaired gastrointestinal function. Symptoms include fever, chills, vomiting, and diarrhea. Treatment focuses on clearing heat and detoxifying, and dispelling dampness and harmonizing the stomach. Third, the syndrome of toxic evil obstructing the lungs, where the main pathogenesis is severe toxic evil obstructing the lungs, leading to impaired lung function. Symptoms include high fever, cough, and irritability. Treatment focuses on clearing heat and purging the lungs, detoxifying and removing blood stasis; fourthly, the main symptoms are internal blockage and external collapse, the main pathogenesis of which is the invasion of pathogenic toxins, qi collapse, yang collapse, and yin depletion. The main manifestations are high fever or fever, cough, etc., and the treatment focuses on strengthening the body's resistance and consolidating the body's defenses.

[0023] In this invention patent, golden lotus, isatis root, and cowpea are used as principal herbs, which together have the effects of clearing heat and detoxifying, clearing toxins, and relieving lung heat. Prunella vulgaris, houttuynia cordata, and Dryopteris crassirhizoma are used as assistant herbs, which clear heat and detoxify, promote diuresis and remove dampness, and enhance the detoxification and antiviral effects of the principal herbs. Astragalus membranaceus and licorice are used as adjuvant herbs, which have the effects of strengthening the spleen, regulating qi, drying dampness, relieving asthma, dispelling wind, dispersing cold, and relieving cough and asthma, further regulating the body's balance and enabling the principal and assistant herbs to play a better role. The combined use of these herbs has a synergistic effect, and together they have the effects of clearing heat and detoxifying, relieving lung heat, relieving cough and asthma, and antiviral effects.

[0024] In addition, the raw materials for the drug of this invention are widely available and inexpensive. Compared with the existing technical solutions, the drug of this invention greatly saves on drug costs. Through experimental verification, it has shown significant effects in preventing and treating avian influenza.

[0025] In addition, the traditional Chinese medicine of this invention is prepared using modern pharmaceutical technology, which allows it to be rapidly absorbed and exert its effects in animals. Furthermore, it can be administered in a concentrated manner using different methods, which is beneficial for the prevention and control of avian influenza. Detailed Implementation

[0026] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the invention.

[0027] Example 1: Preparation and Use of the Drug of the Present Invention

[0028] (1) Weigh the raw materials containing the following weights:

[0029] 60 parts of golden lotus, 20 parts of isatis root, 20 parts of prunella vulgaris, 30 parts of houttuynia cordata, 20 parts of dryopteris crassirhizoma, 60 parts of cowpea, 30 parts of astragalus membranaceus, and 10 parts of licorice.

[0030] (2) The raw medicinal materials weighed in step (1) are ultra-finely pulverized, thoroughly mixed and prepared into a powder. The particle size of the powder is not higher than 50 micrometers.

[0031] (3) Method of using the drug of the present invention: for the prevention and treatment of avian influenza, mixed feed: add 1 kg of the Chinese medicine of the present invention per 1 ton of feed for 7-10 consecutive days.

[0032] Example 2: Preparation and Use of the Drug of the Present Invention

[0033] (1) Weigh the raw materials containing the following weights:

[0034] 100 parts of golden lotus, 80 parts of isatis root, 60 parts of prunella vulgaris, 80 parts of houttuynia cordata, 50 parts of dryopteris crassirhizoma, 120 parts of cowpea, 50 parts of astragalus membranaceus, and 30 parts of licorice.

[0035] (2) After coarsely crushing the raw medicinal materials weighed in step (1), soak the medicinal materials in distilled water for 0.5h, decoct them 3 times, the first time for 2 hours, the second and third times for 1.0h each, combine the filtrates and concentrate them into a thick paste, add appropriate amount of starch, dextrin and 5% citric acid (or other excipients), mix evenly, granulate, dry and prepare granules (each 1g is equivalent to 2g of raw medicinal materials).

[0036] (3) Method of using the drug of the present invention: for the prevention and treatment of avian influenza, mixed drinking: add 0.5 kg of the drug of the present invention to every 1 ton of water, drink freely, for 7-10 consecutive days.

[0037] Example 3: Preparation and Use of the Drug of the Present Invention

[0038] (1) Weigh the raw materials containing the following weights:

[0039] 70 parts of golden lotus, 40 parts of isatis root, 30 parts of prunella vulgaris, 40 parts of houttuynia cordata, 30 parts of dryopteris crassirhizoma, 80 parts of cowpea, 35 parts of astragalus membranaceus, and 15 parts of licorice.

[0040] (2) After coarsely crushing the raw medicinal materials weighed in step (1), soak the medicinal materials in distilled water for 0.5 hours, then decoct them 3 times, the first time for 1.5 hours, the second and third times for 1.0 hours each. Combine the filtrates and concentrate them into a thick paste. Add an appropriate amount of starch, dextrin and 5% citric acid (or other excipients), mix evenly, and spray dry to prepare powder (each 1g is equivalent to 2g of raw medicinal materials).

[0041] (3) Method of using the drug of the present invention: It is used for the prevention and treatment of avian influenza. It is mixed with feed, and 0.5-1 kg of the Chinese medicine of the present invention is added to every 1 ton of feed for 7-10 consecutive days.

[0042] Example 4: Preparation and use of the drug of the present invention

[0043] (1) Weigh the raw materials containing the following weights:

[0044] 90 parts of golden lotus, 60 parts of isatis root, 50 parts of prunella vulgaris, 70 parts of houttuynia cordata, 45 parts of dryopteris crassirhizoma, 100 parts of cowpea, 45 parts of astragalus membranaceus, and 25 parts of licorice.

[0045] (2) After coarsely crushing the raw medicinal materials weighed in step (1), soak the medicinal materials in distilled water for 0.5 hours, then decoct them 3 times, the first time for 1.5 hours, the second and third times for 1.0 hours each. Combine the filtrates and concentrate them to a certain volume (equivalent to 1g / ml of Chinese medicine). Add ethanol to the concentrate to make the alcohol content 70%, filter, recover the ethanol from the filtrate, concentrate to 1ml equivalent to 2g of raw medicine, filter, fill and sterilize to prepare oral liquid.

[0046] (3) Method of using the drug of the present invention: for the prevention and treatment of avian influenza, mixed drinking: add 1000ml of the drug of the present invention to every 1 ton of water, drink freely, for 7-10 consecutive days.

[0047] Example 5: Preparation and Use of the Drug of the Present Invention

[0048] (1) Weigh the raw materials containing the following weights:

[0049] 80 parts of golden lotus, 50 parts of isatis root, 40 parts of prunella vulgaris, 60 parts of houttuynia cordata, 36 parts of dryopteris crassirhizoma, 90 parts of cowpea, 40 parts of astragalus membranaceus, and 20 parts of licorice.

[0050] (2) After coarsely crushing the raw medicinal materials weighed in step (1), soak the medicinal materials in distilled water for 0.5 hours, then decoct them 3 times, the first time for 1.5 hours, the second and third times for 1.0 hours each. Combine the filtrates and concentrate them to a certain volume (equivalent to 1.0 g / ml of Chinese medicine). Add ethanol to the concentrate to make the alcohol content 70%, filter, recover the ethanol from the filtrate, concentrate it to 1 ml equivalent to 2 g of raw medicine, filter, fill and sterilize to prepare oral liquid.

[0051] (3) Method of using the drug of the present invention: for the prevention and treatment of avian influenza, mixed drinking: add 1000mL of the drug of the present invention to every 1 ton of water, drink freely, for 7-10 consecutive days.

[0052] To demonstrate the efficacy of the drug of the present invention in preventing and treating avian influenza, a clinical efficacy observation test was conducted on the drug of the present invention. The following test examples further illustrate the beneficial effects of the drug of the present invention.

[0053] Comparative Example 1

[0054] A drug for the prevention and treatment of H7 subtype avian influenza, its preparation method and application, by weight: 10 parts of Scutellaria baicalensis, 10 parts of Lonicera japonica, 20 parts of Forsythia suspensa, 5 parts of Illicium verum, 10 parts of Houttuynia cordata, 5 parts of Mentha haplocalyx, 10 parts of Platycodon grandiflorus, 5 parts of Perilla frutescens, and 10 parts of Glycyrrhiza uralensis.

[0055] The preparation method of the above-mentioned drug preparation for preventing and treating H7 subtype avian influenza is as follows: weigh the above-mentioned raw materials and pulverize them to obtain the preparation.

[0056] Comparative Example 2

[0057] A traditional Chinese medicine for the prevention and treatment of avian influenza contains, by weight: 50 parts honeysuckle, 100 parts forsythia, 50 parts scutellaria, 50 parts isatis root, 50 parts dryopteris crassirhizoma, 30 parts houttuynia cordata, 75 parts astragalus, and 50 parts bupleurum.

[0058] After coarsely pulverizing the weighed raw medicinal materials, soak them in distilled water for 0.5 hours, then decoct them three times: 1.5 hours for the first time, and 1.0 hour each for the second and third times. Combine the filtrates and concentrate them to a certain volume (equivalent to 1.0 g / ml of Chinese medicine). Add ethanol to the concentrate to make the alcohol content 70%, filter, recover the ethanol from the filtrate, concentrate to 1 ml equivalent to 2 g of raw medicine, filter, fill, and sterilize to prepare the oral liquid.

[0059] Comparative Example 3

[0060] A traditional Chinese medicine for preventing and treating avian influenza contains, by weight: 35 parts honeysuckle, 10 parts schizonepeta, 20 parts wild chrysanthemum, 20 parts oldenlandia diffusa, 15 parts astragalus, 10 parts licorice, 15 parts bupleurum, 10 parts dryopteris crassirhizoma, 10 parts coptis chinensis, 20 parts isatis root, 20 parts indigo leaf, 20 parts houttuynia cordata, 15 parts patrinia scabiosaefolia, 10 parts Paris polyphylla, 10 parts belamcanda chinensis, 15 parts forsythia, 20 parts scutellaria baicalensis, 10 parts bitter almond, 10 parts fritillaria thunbergii, 10 parts mulberry bark, 10 parts cuscuta chinensis, and 20 parts prunella vulgaris.

[0061] After coarsely pulverizing the weighed raw medicinal materials, soak them in distilled water for 0.5 hours, then decoct them three times: 1.5 hours for the first time, and 1.0 hour each for the second and third times. Combine the filtrates and concentrate them to a certain volume (equivalent to 1.0 g / ml of Chinese medicine). Add ethanol to the concentrate to make the alcohol content 70%, filter, recover the ethanol from the filtrate, concentrate to 1 ml equivalent to 2 g of raw medicine, filter, fill, and sterilize to prepare the oral liquid.

[0062] To demonstrate the efficacy of the drug of the present invention in preventing and treating avian influenza, a clinical efficacy observation test was conducted on the drug of the present invention. The following test examples further illustrate the beneficial effects of the drug of the present invention.

[0063] Experimental Example 1

[0064] In May 2024, some of the 50,000 35-day-old broiler chickens raised by Li in Guizhou Province showed symptoms such as coughing, snoring, fever, poor mental state, and decreased feed and water intake. After avian influenza antibody testing, pathological necropsy changes, and clinical symptoms, the chickens were diagnosed with avian influenza.

[0065] 45,100 broilers with obvious clinical symptoms were divided into 10 groups: groups 1-9 each had 5,000 birds, and group 10 had 100 birds. Groups 1-5 were the experimental groups, using the drugs prepared in Examples 1-5 of this invention, administered according to the methods described in Examples 1-5, for 7 consecutive days. Groups 6-8 were the comparative example 1 drug group, comparative example 2 drug group, and comparative example 3 drug group, respectively, using the drugs prepared in comparative examples 1, 2, and 3. Comparative example 1 was administered via feed mixing at a rate of 2.0 kg of comparative example 1 drug per ton of feed, while comparative examples 2 and 3 were administered via drinking water mixing at a rate of 1.0 L of comparative example drug solution per ton of water. All birds had free access to feed and water for 7 consecutive days. Group 9 used amantadine hydrochloride as the control group, administered via drinking water mixing at a rate of 1.0 g of amantadine hydrochloride per 1 L of water for 7 consecutive days. Group 10, with 100 birds, served as the blank control group, receiving no medication. All other feeding conditions were basically the same.

[0066] Clinical efficacy was assessed 7 days after administration. If clinical symptoms disappeared within 7 days and did not recur within 9 days, the patient was considered cured; if no clinical symptoms appeared within 14 days, the patient was considered effective; otherwise, the patient was considered ineffective. These criteria were used to determine efficacy, and the results are shown in Table 1.

[0067] Table 1. Statistical analysis of the efficacy of the drug of the present invention against avian influenza in broilers.

[0068]

[0069] As shown in Table 1, compared with the blank control group (10 groups), the cure rate and effectiveness of the drug of the present invention, comparative drug 1, comparative drug 2, comparative drug 3, and control drug amantadine hydrochloride in treating avian influenza in broilers were significantly higher than those of the blank control group. This indicates that the drug of the present invention, comparative drug 1, comparative drug 2, comparative drug 3, and control drug amantadine hydrochloride are significantly effective in treating avian influenza in broilers. Compared with the amantadine hydrochloride control group, the cure rate and effectiveness of the drug of the present invention are superior to those of the control drug group. The comparative drug groups 1, 2, and 3 are inferior to those of the control drug amantadine hydrochloride group in terms of cure rate and effectiveness. Compared with the comparative drug groups 1, 2, and 3, the drug of the present invention is superior to the comparative drug groups 1, 2, and 3 in treating avian influenza in broilers. Moreover, among the drugs of the present invention, the drug prepared in Example 5 has the best cure rate and effectiveness in broilers. Example 5 is the optimal prescription for the drug of the present invention, indicating that the drug of the present invention is significantly effective in treating avian influenza in broilers.

[0070] Experimental Example 2

[0071] In February 2023, sporadic deaths and green droppings occurred in 15,000 270-day-old laying hens at a chicken farm owned by Mr. Yang in Hebei Province. The hens' overall condition and appetite remained normal, although a few exhibited coughing and wheezing. Egg production slightly decreased, and eggshells became whitish, with an increase in sandy-shelled, soft-shelled, and thin-shelled eggs. Dissection revealed congestion and hemorrhage in the larynx and trachea, with viscous secretions. Some hens showed oviduct edema or atrophy, follicle congestion and hemorrhage, and slight hemorrhage in the proventricular papillae. Avian influenza was diagnosed after antibody testing, combined with clinical symptoms and pathological changes. The drug prepared according to Example 5 of this invention was administered orally to 1000 mL of the drug per ton of water, with free access to drinking water, for 7 consecutive days. Seven days later, the cough symptoms had largely disappeared, and the chickens' water intake, feed consumption, mental state, and feces were generally normal. The quality of the eggs laid by the chickens was also better than during the disease outbreak period. A total of 15 chickens died during the treatment period. There were no recurrences of the disease within 15 days, and the egg production rate of the laying hens began to rise. Ten days after treatment, the egg production rate returned to normal levels. The results indicate that the drug of this invention is significantly effective in preventing and treating avian influenza.

[0072] Experimental Example 3

[0073] In April 2025, 10,000 30-day-old broiler chickens raised by Mr. Kong in Shandong Province exhibited the following symptoms: some chickens had elevated body temperature, a few showed lethargy, reduced feed intake, ruffled feathers, hunched necks, white or pale yellow watery droppings, unsteady gait, and sporadic deaths. Pathological examination of the dead chickens revealed swelling of the head and neck, subcutaneous edema, conjunctival congestion and redness (some even with hemorrhage), coughing, and nasal discharge. Based on avian influenza antibody testing, pathological findings, and clinical symptoms, a diagnosis of avian influenza was confirmed. The drug prepared in Example 3 of this invention was used, with 1 kg of the drug added per ton of feed for 7 consecutive days, with free access to water and feed. Seven days later, all respiratory symptoms disappeared, and the chickens' water intake, feed intake, mental state, and fecal condition returned to normal. A total of 29 chickens died during the treatment period. No recurrence of the disease occurred within seven days after administration; the flock's water intake, feed intake, mental state, and fecal color were all normal, with no respiratory symptoms, and growth rate returned to normal. The results indicate that the drug of this invention is significantly effective in treating avian influenza.

[0074] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.

Claims

1. A traditional Chinese medicine composition for preventing and treating avian influenza, characterized in that, It contains active ingredients made from golden lotus, isatis root, prunella vulgaris, houttuynia cordata, dryopteris crassirhizoma, cowpea, astragalus, and licorice.

2. The traditional Chinese medicine composition for preventing and treating avian influenza according to claim 1, characterized in that, The active ingredients are made from 60-100 parts of golden lotus, 20-80 parts of isatis root, 20-60 parts of prunella vulgaris, 30-80 parts of houttuynia cordata, 20-50 parts of dryopteris crassirhizoma, 60-120 parts of cowpea, 30-50 parts of astragalus membranaceus, and 10-30 parts of licorice.

3. The traditional Chinese medicine composition for preventing and treating avian influenza according to claim 2, characterized in that, The active ingredients are made from 70-90 parts of golden lotus, 40-60 parts of isatis root, 30-50 parts of prunella vulgaris, 40-70 parts of houttuynia cordata, 30-45 parts of dryopteris crassirhizoma, 80-100 parts of cowpea, 35-45 parts of astragalus membranaceus, and 15-25 parts of licorice.

4. The traditional Chinese medicine composition for preventing and treating avian influenza according to claim 3, characterized in that, The active ingredients consist of 80 parts of golden lotus, 50 parts of isatis root, 40 parts of prunella vulgaris, 60 parts of houttuynia cordata, 36 parts of dryopteris crassirhizoma, 90 parts of cowpea, 40 parts of astragalus membranaceus, and 20 parts of licorice.

5. A method for preparing a traditional Chinese medicine composition for preventing and treating avian influenza according to any one of claims 1-4, characterized in that, Includes the following steps: (1) Weigh each drug raw material according to the weight ratio; (2) The weighed drug raw materials are crushed and sieved, or the weighed drug raw materials are extracted and concentrated by water or alcohol, and then directly prepared or prepared by adding pharmaceutically usable excipients or auxiliary ingredients.

6. The method for preparing the traditional Chinese medicine composition for preventing and treating avian influenza according to claim 5, characterized in that, The dosage forms obtained include powders, premixes, granules, or oral liquids.

7. The method for preparing the traditional Chinese medicine composition for preventing and treating avian influenza according to claim 6, characterized in that, The particle size of the powder is less than 50 micrometers; each 1g of granules and powder is equivalent to 2g of raw medicinal material; each 1ml of oral liquid is equivalent to 2g of raw medicinal material.

8. The use of the traditional Chinese medicine composition for preventing and treating avian influenza according to any one of claims 1-4 in the preparation of drugs for preventing and treating avian influenza.

9. The use of the traditional Chinese medicine composition for preventing and treating avian influenza according to any one of claims 1-4 in the preparation of feed for preventing and treating avian influenza.

10. Feed containing the traditional Chinese medicine composition for preventing and treating avian influenza according to any one of claims 1-4.

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