Wall-pushing type membrane-turning dosing device

Abstract

The invention relates to the technical field of medical apparatus and instruments, in particular to a wall-pushing type film-turning dosing device which comprises a film blind tube and an opening tube, the closed end of the film blind tube extends into the opening tube, the opening end of the film blind tube is connected with a stopping part, and the stopping part is connected or contacted with the opening tube; at least in an initial state, the upper end of the opening pipe is far away from the closed end. The vaginal drug delivery device is simple in structure, smaller in mass, beneficial to reducing or avoiding pollution after drug delivery, flexible in use mode, capable of remarkably improving the applicability and comfort of vaginal drug delivery, and particularly suitable for being used under the conditions that vagina is dry and a lubricant is not suitable for being used during drug delivery.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, specifically to a push-wall type membrane delivery device. Background Technology

[0002] Vaginal administration is a local drug delivery method in which a drug preparation (such as suppositories, gels, tablets, creams, etc.) is placed directly into the vaginal cavity, allowing the drug to exert its therapeutic effect locally in the vagina or through absorption via the mucosa. Vaginal administration is mainly used to treat vaginal and cervical diseases, and is characterized by high local drug concentrations and few systemic adverse reactions. To avoid infection during administration, auxiliary delivery devices are usually used.

[0003] Currently, commonly used delivery devices include plunger-type devices. When administering medication, the tip of the device is aligned with the vaginal opening, and the delivery tube is pushed horizontally through the vagina until it reaches a certain point. Then, the plunger is pushed forward to expel the medication. During the insertion and removal of this type of device from the vagina, the outer wall of the delivery tube slides and rubs against the inner vaginal wall, easily causing secondary damage to the vaginal wall. This is especially problematic for individuals experiencing vaginal dryness who cannot use lubricants, as it can cause mucosal damage, worsen discomfort, reduce drug efficacy, and severely hinder the implementation of intravaginal medication.

[0004] Chinese Patent CN111888633B discloses a vaginal drug delivery device and method. The vaginal drug delivery device includes a flexible tube sleeve, which comprises a tube body and tube bottoms and tube openings located at both ends of the tube body. The tube body includes an inner wall and an outer wall, and the inner wall and the tube bottom together form a accommodating space for holding a drug. The flexible tube sleeve is used to evert the inner wall into the vagina so that the drug in the accommodating space enters the vagina evenly. By using a flexible tube sleeve, the drug is placed in the accommodating space within the flexible tube sleeve. During the specific drug delivery stage, only the tube bottom needs to be pushed to evert the inner wall of the flexible tube sleeve into the vagina, thereby making the drug in the accommodating space evenly distributed in the vagina. Compared with the rough drug delivery method of a plunger, the inner wall of the flexible tube sleeve in this application rolls outward like a track into the vagina, which will not cause secondary damage to the inside of the vagina.

[0005] However, the above-mentioned technology has the following problems: 1. Relying solely on the flexible sleeve not only makes it difficult to achieve the required drug delivery depth, but also makes it difficult to achieve the track-like rolling motion during removal. In fact, it will still cause secondary damage to the vaginal wall, especially when the hardness and thickness of the flexible sleeve are small, the ability of the tube wall to transmit thrust will decrease accordingly, making it even more difficult to solve the technical problem of reducing friction damage to the vaginal wall; Although the cooperation of the push rod and the support sleeve helps to improve technical feasibility, since the tube body is attached to the inner side of the support sleeve, there is a large friction between the tube body and the inner side of the support sleeve without lubrication. This is even more pronounced when the flexible sleeve is made of silicone. By applying a pushing force to the bottom of the tube through the push rod, the tube body is not easy to slide on the inner wall of the support sleeve. The push rod will push the bottom of the tube forward, and at the same time, the tube wall of the flexible sleeve will be driven by the bottom of the tube to fold inside and outside the support sleeve (only when the outer diameter of the push rod is smaller than the flexible sleeve). It is feasible to reduce the inner diameter of the flexible sheath by twice the wall thickness of the flexible sheath (but if it is equal to or greater than this, jamming may occur). When the flexible sheath is everted and extends from the front end of the supporting sheath into the vagina, the eversion movement of the flexible sheath still only occurs within the supporting sheath. The movement of the part of the flexible sheath extending from the supporting sheath relative to the vaginal wall is essentially a traditional relative sliding movement. In the absence of lubrication, it is also difficult to solve the technical problem of reducing friction damage to the vaginal wall in cases of dryness. 2. The bottom of the tube needs to have a certain degree of rigidity. However, a tube bottom with a certain degree of rigidity is prone to causing discomfort when entering and exiting the vagina. In addition, designing a top plate with a diameter larger than the inner diameter of the tube body to improve the rigidity of the tube bottom will further increase the discomfort when the bottom of the tube enters and exits the vagina. 3. A special top rod is required to apply a pushing force to the bottom of the tube, and a thin-film flexible sheath is not suitable, resulting in a complex structure and greater weight.

[0006] Therefore, a push-wall type film-flipping drug delivery device was proposed. Summary of the Invention

[0007] The present invention aims to provide at least one push-wall type flip-film delivery device that is more conducive to reducing or avoiding post-medication contamination and improving the suitability and comfort of drug administration.

[0008] To achieve the above objectives, the present invention provides the following technical solution:

[0009] This invention provides a push-wall type transvaginal drug delivery device, comprising a thin-film blind tube and an open tube. The closed end of the thin-film blind tube extends into the open tube, and the open end of the thin-film blind tube is connected to a stop member, which is connected to or in contact with the open tube. At least in the initial state, the upper end of the open tube is away from the closed end. The initial state refers to the state when the upper end (i.e., the front end) of the push-wall type transvaginal drug delivery device enters the patient's vaginal opening in preparation for drug delivery.

[0010] Optionally, the opening tube is a tube body with an open upper end, a closed lower end, and a through hole or connector on the side wall; or the opening tube is a tube body with an open upper end, a hole at the lower end for a movable sealing insertion pull member, and a through hole or connector on the side wall; or the opening tube is a tube body with open ends, and the through hole or connector or the lower opening of the opening tube is used for ventilation and / or for connecting other functional components (e.g., inserting a piston assembly, or connecting a connecting tube, and / or an inflation member).

[0011] Optionally, the closed end is connected to a pull member.

[0012] Optionally, the pull member may include a film tube or a pull rope (e.g., a thin rope made of polyethylene plastic).

[0013] Optionally, the pull rope is pre-formed into a spring shape that can hang down through the lower opening of the tube.

[0014] Optionally, an easy-tear line, such as a dotted line or a half-cut line, is provided between the film tube and the closed end.

[0015] Optionally, the length of the pull member is greater than or equal to the length of the opening tube. Further, the length of the pull member is greater than or equal to 1.5 times the length of the opening tube (for example, when the pull member also serves to pull the part of the membrane blind tube inserted into the vagina out of the vagina).

[0016] Optionally, the closed end is connected to a hook.

[0017] Optionally, the stop member is provided with a gap, which is at least used to allow an opening tube with an outer diameter greater than the inner diameter of the stop member to pass through the stop member (for example, to make the stop member have a variable inner diameter, so that the stop member can slide outside the opening tube with a variable outer diameter, and / or be limited, etc.), and to improve the connection efficiency between the stop member and the membrane blind tube (for example, as a channel for the membrane blind tube to enter the stop member during automated connection).

[0018] Optionally, the gap is parallel to the axis of the stop.

[0019] Optionally, the stopper may include an elastomer ring such as a rubber ring or a polyurethane ring.

[0020] Optionally, the stop is made of plastic materials such as polypropylene, polyethylene, or polyvinyl chloride.

[0021] Optionally, the closed end is formed by welding the membrane tube, connecting a hook, or connecting a plug.

[0022] Optionally, the inner wall of the opening pipe is connected to a flow guide, which is at least used to guide the air entering the opening pipe to flow along the inner wall of the opening pipe, and at least used to avoid or reduce the impact of airflow on the closing end.

[0023] Optionally, the flow guide includes a blind tube.

[0024] Optionally, the outer end face of the closed end of the blind tube is a plane or a hemispherical surface.

[0025] Optionally, the inner wall of the opening pipe and / or the outer wall of the guide member are provided with ventilation grooves. The ventilation grooves are used to ensure that the air entering the opening pipe flows smoothly and / or evenly to the upper part of the opening pipe, and to avoid situations such as the inner wall of the opening pipe sticking to the side wall of the membrane blind tube, which would affect ventilation.

[0026] Optionally, a blunt-tipped tube is slidably inserted into the opening tube.

[0027] Optionally, the blunt-mouthed tube is a blind tube or other flow guide with a blunt-mouthed upper end.

[0028] Optionally, the upper end and / or inner surface of the blunt-tipped tube may contact the sidewall of the thin-film blind tube.

[0029] Optionally, the length of the blunt end tube is greater than or equal to 1.5 times the length of the open tube.

[0030] Optionally, the flow guide and / or the blunt-tipped tube are provided with holes, the holes on the blunt-tipped tube being used for ventilation, or for ventilation and for the pull member to pass through; the holes on the flow guide are at least used for the pull member to pass through.

[0031] Optionally, the radial cross-sectional shape of the opening pipe is circular or elliptical.

[0032] Optionally, the opening pipe includes one or more combinations of straight pipe, bend pipe, reducing pipe, and arc-shaped pipe.

[0033] Optionally, the upper outer diameter of the opening tube is larger than the middle and lower outer diameters. This variable diameter design is used to adjust the position of the stopper on the opening tube and the matching relationship between the stopper and the opening tube by changing the cooperation relationship with the stopper, thereby adjusting the drug delivery depth and / or the position of the closed end; or the upper outer diameter of the opening tube is smaller than the middle and lower outer diameters. This variable diameter design is mainly used to increase the change in the volume of the opening tube caused by the sliding of the piston in the opening tube and to limit the depth of the opening tube inserted into the vagina.

[0034] Optionally, the outside of the opening tube is provided with a wing, which functions the same as the wing on the outside of the syringe barrel of a conventional syringe product.

[0035] Optionally, the outside of the opening tube is provided with scale markings, which are used to indicate the volume and / or the depth to which the closed end extends into the opening tube (also used to reflect the approximate depth of drug administration).

[0036] Optionally, at least one end of the opening tube is provided with a blunt end.

[0037] Optionally, at least one end of the opening tube or the blunt tube is provided with an inner convex blunt opening, which is at least used to hook (hook) the hook member.

[0038] Optionally, the blunt opening and / or the inner convex blunt opening may be provided with a low surface energy coating, micro / nano hydrophobic / oleophobic structure, etc., to further reduce surface adhesion and friction.

[0039] Optionally, a piston assembly is slidably sealed inside the opening tube; or a connecting tube is connected to the lower part or side of the opening tube, and / or an inflation component is connected thereto, the inflation component including an inflation ball, a syringe assembly, etc.; the syringe assembly is the remaining part of a traditional syringe with the needle removed, and is a partial component of the syringe, not a complete syringe; the piston assembly is composed of a piston head and one end of a piston rod connected together.

[0040] Optionally, a pull member is connected between the piston assembly and the closed end.

[0041] Optionally, the inner diameter of the connecting pipe away from the open pipe section is reduced, or the inner diameter of the connecting pipe is larger than the inner diameter of the air outlet of the inflation component, so as to reduce the air flow velocity of the connecting pipe used to connect to the open pipe end (i.e., using the principle that the flow rate remains constant, the pipe diameter increases, and the flow velocity decreases).

[0042] Optionally, the connecting tube is a flexible tube, and during use, air can be blown into the end of the connecting tube away from the through tube.

[0043] Optionally, the opening pipe, the connecting pipe, or the inflation component is equipped with a pressure relief valve to ensure that the inflation pressure entering the opening pipe does not exceed the set pressure (i.e., to avoid the membrane blind tube from bursting or undergoing large deformation).

[0044] Optionally, the pressure relief valve is a short tube made of elastomeric material, which is fitted onto an open pipe with a hole in its wall, or onto a connecting pipe with a hole in its wall, or onto an inflation component with a hole in its wall. The short tube seals and covers the hole. When the air pressure in the hole reaches a certain value, the overpressure gas in the hole can push up part of the short tube and leak out from the hole.

[0045] Optionally, the lower end of the pull member is connected to a sealing plug, and a connector is connected to the sealing plug. The sealing plug is detachably and sealably connected to the lower opening of the opening tube, and the connector is used to connect the connecting tube or the inflation member.

[0046] Optionally, the hook includes a rod-shaped object, a C-shaped object, or a ring-shaped object connected to the closed end. The length of the rod-shaped object is less than the inner diameter of the opening tube or less than the inner diameter of the blunt-mouth tube, but greater than the diameter of the inner convex blunt mouth. The outer diameter of the C-shaped object or the ring-shaped object is less than the inner diameter of the opening tube or less than the inner diameter of the blunt-mouth tube, but greater than the diameter of the inner convex blunt mouth.

[0047] Optionally, the inner diameter of the thin-film blind tube is larger than the outer diameter of the blunt-mouth tube.

[0048] Optionally, the outer wall surface of the membrane blind tube is provided with a protrusion, which is used to support the formation of an air gap between the outer walls of the membrane blind tube.

[0049] Optionally, the outer surface of the thin-film blind tube, or the inner surface and upper end of the open tube, or the inner surface and upper end of the blunt tube, are coated with a lubricating substance to reduce surface adhesion and friction.

[0050] Optionally, a cap or plug may be detachably connected inside the membrane blind tube.

[0051] Optionally, the film blind tube is made of an elastomer material such as modified polyethylene, polyvinyl chloride, or thermoplastic polyurethane, which has flexibility and low friction.

[0052] Optionally, the opening tube and the blunt end tube are made of plastics such as PP or PET.

[0053] Optionally, the opening tube and the blunt end tube are made of transparent plastic.

[0054] Due to the adoption of the above technical solutions, the advantages of this invention are as follows:

[0055] 1. During vaginal administration, the wall of the blind-tube of this invention contacts the vaginal wall by everting, and the closed end gradually extends deep into the vagina. Finally, the inner wall of the blind-tube fully everts to deliver the drug into the vagina. After administration, as the closed end is pulled down to remove the drug from the vagina, the wall of the blind-tube detaches from the vaginal wall by everting from the closed end and gradually moves out of the vagina. During the administration process, the wall of the blind-tube moves relative to the vaginal wall in a manner similar to a track rolling motion. The blind-tube is less likely to slip relative to the vaginal wall, thus avoiding or reducing friction with the vaginal wall and minimizing irritation. This is especially beneficial for administration situations with dryness symptoms where the use of lubricants should be avoided or is subject to strict requirements. It has outstanding applicability and / or ease of use.

[0056] 2. After the administration of the drug in this invention is completed, during the process of removing the membrane blind tube from the vagina, the inner wall of the membrane blind tube that has come into contact with the affected area is turned inward, so that the contaminated inner wall surface of the membrane blind tube is not easily or rarely exposed, which helps to reduce or avoid contamination.

[0057] 3. The present invention can use a thin-film blind tube, and some embodiments can eliminate the need for push rods and pistons, which can significantly simplify the structure, greatly reduce the amount of material used, and avoid the use of high-density elastomer materials such as silicone, which at least helps to significantly reduce weight.

[0058] 4. The present invention can use a thin-film blind tube, and in some embodiments, the thin-film blind tube can enter and exit the vagina in an almost track-rolling manner, which is beneficial to significantly reduce the stimulation and damage of the rigid structure to the vaginal wall during vaginal administration, and significantly improve the feasibility and comfort of vaginal administration.

[0059] 5. This invention can achieve low-irritation and low-damage vaginal drug delivery by using air pressure, pushing open the tube, or pushing the blunt end of the tube, making it flexible in its use. Attached Figure Description

[0060] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0061] Figure 1 This is a side view schematic diagram of Embodiment 1 of the push-wall type flip-film drug delivery device provided by the present invention;

[0062] Figure 2 for Figure 1 Axial sectional view;

[0063] Figure 3 From Figure 1 A schematic axial cross-sectional view of the lower end of the provided push-wall type flip-film drug delivery device after a certain amount of air has been filled;

[0064] Figure 4 From Figure 3 A schematic axial cross-sectional view of the lower end of the provided push-wall type flip-film drug delivery device after a certain amount of air has been continuously injected;

[0065] Figure 5 A side view schematic diagram of Embodiment 2 of the push-wall type flip-film drug delivery device provided by the present invention;

[0066] Figure 6 for Figure 5 A schematic diagram of the axial half section;

[0067] Figure 7 To be Figure 1 or Figure 5 A side view of the lower end of the balloon after it is connected to the inflation component (balloon) via a variable diameter hose;

[0068] Figure 8 A side view schematic diagram of Embodiment 1 of the thin-film blind tube provided by the present invention;

[0069] Figure 9 A side view schematic diagram of Embodiment 2 of the thin-film blind tube provided by the present invention;

[0070] Figure 10 A side view schematic diagram of Embodiment 3 of the thin-film blind tube provided by the present invention;

[0071] Figure 11 A side view schematic diagram of embodiment 4 of the thin-film blind tube provided by the present invention;

[0072] Figure 12 A side view schematic diagram of embodiment 5 of the thin-film blind tube provided by the present invention;

[0073] Figure 13 A side view schematic diagram of Embodiment 6 of the thin-film blind tube provided by the present invention;

[0074] Figure 14 A side view schematic diagram of embodiment 7 of the thin-film blind tube provided by the present invention;

[0075] Figure 15 This is a side view schematic diagram of Embodiment 3 of the push-wall type flip-film drug delivery device provided by the present invention;

[0076] Figure 16 for Figure 15 A schematic diagram of an axial section;

[0077] Figure 17 To maintain Figure 16 A schematic diagram of the axial section after the middle stop is stationary and the pipe is pushed up (i.e., pushed forward) to the end;

[0078] Figure 18 To maintain Figure 17 The diagram shows the axial cross-section of the tube after it is pulled down (i.e., after administration of medication into the vagina, it is pulled down from both inside and outside the vagina) a certain distance while the blocking component remains stationary.

[0079] Figure 19 To maintain Figure 18 A schematic diagram of the axial section after the blocking component remains stationary and the opening pipe is pulled down to the end;

[0080] Figure 20 for Figure 15 Another axial cross-sectional view (i.e., the axial cross-sectional view of embodiment 4 of the push-wall type flip-film drug delivery device).

[0081] Figure 21 To maintain Figure 20 A schematic diagram of the axial section after the blocking part in the middle is not moved and the tube is pushed up (i.e., pushed forward into the vagina) to the end;

[0082] Figure 22 To maintain Figure 21 The diagram shows the axial cross-section of the tube after it is pulled down (i.e., after administration of medication into the vagina, it is pulled down from both inside and outside the vagina) a certain distance while the blocking component remains stationary.

[0083] Figure 23 To maintain Figure 22 A schematic diagram of the axial section after the blocking component remains stationary and the opening pipe is pulled down to the end;

[0084] Figure 24 A side view schematic diagram of Embodiment 5 of the push-wall type flip-film drug delivery device provided by the present invention;

[0085] Figure 25 for Figure 24 A schematic diagram of an axial section;

[0086] Figure 26 A schematic axial cross-sectional view of Embodiment 6 of the push-wall type flip-film drug delivery device provided by the present invention;

[0087] Figure 27 This is an axial cross-sectional schematic diagram of Embodiment 7 of the push-wall type flip-film drug delivery device provided by the present invention;

[0088] Figure 28 To be Figure 27 A front view diagram of the provided push-wall type flip-film drug delivery device after it is connected to the syringe assembly;

[0089] Figure 29 This is an axial cross-sectional schematic diagram of Embodiment 8 of the push-wall type flip-film drug delivery device provided by the present invention;

[0090] Figure 30 This is an axial cross-sectional schematic diagram of Embodiment 9 of the push-wall type flip-film drug delivery device provided by the present invention.

[0091] In the diagram: 1. Drug; 2. Convex blunt end; 3. Hole; 4. Pressure relief valve; 5. Pull rope; 6. Elastomer short tube; 10. Membrane blind tube; 11. First membrane tube; 111. Protrusion; 12. Second membrane tube; 13. Closed end; 14. Stop; 141. Gap; 15. Hook; 16. Plug; 161. Protrusion; 20. Opening tube; 21. Tube body; 211. Large diameter section; 2 111. Abutment surface; 212. Middle diameter section; 213. Small diameter section; 22. Ventilation groove; 23. Scale markings; 24. Wing; 30. Flow guide; 40. Blunt end tube; 50. Inflatable ball; 51. Connecting tube; 60. Sealing plug; 61. Connector; 70. Syringe assembly; 71. Syringe; 72. Piston assembly; 721. Piston rod; 722. Piston; 100. Push-wall type flip-film drug delivery device. Detailed Implementation

[0092] In the description of this invention, it should be noted that when terms such as "upper," "lower," "inner," "outer," "left," "right," "front," and "rear" appear, indicating orientation or positional relationships, they are based on the orientation or positional relationships shown in the accompanying drawings, or the orientation or positional relationships in which the product of this invention is conventionally placed during use. This method of expression is only for the convenience and simplification of describing this invention, and is not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation; therefore, it should not be construed as a limitation of this invention.

[0093] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated.

[0094] It should be noted that, where there is no conflict, the features in the embodiments of the present invention can be combined with each other.

[0095] The specific implementation method is described below:

[0096] Example 1 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 7 , Figure 8The device includes a membrane blind tube 10 and an opening tube 20. The membrane blind tube 10 is composed of a first membrane tube 11 with one end sealed and welded (forming a closed end 13). The outer wall surface of the first membrane tube 11 has several parallel protrusions 111 along its length. The closed end 13 of the membrane blind tube 10 extends into the opening tube 20. The open end of the membrane blind tube 10 is turned outward and fitted over the upper part of the opening tube 20, and is fixedly and sealed to the upper part of the outer wall surface of the opening tube 20 by a stopper 14. The opening tube 20 is a tube with blunt ends. The outer wall of the opening tube 20 is marked with scale marks 23. The inner wall is clamped with a guide 30. The outer wall of the guide 30 is provided with a ventilation groove 22 (i.e. a groove for ventilation) along its length. When the air flow rate into the opening tube 20 is low, the guide 30 can also be removed in this embodiment. In the initial state, the upper end of the opening tube 20 is in contact with the upper part of the outer wall of the membrane blind tube 10 and away from the closed end 13.

[0097] In this embodiment, the opening tube 20 can be a straight round tube made of transparent PET plastic with an outer diameter of 12mm, an inner diameter of 10mm, and a length of 100mm. Optionally, an annular groove or protrusion can be provided on the upper part of the outer wall of the opening tube 20 for engaging the limiting stop 14. The stop 14 can be made, for example, a flexible polyvinyl chloride tube, polyurethane tube, or polyethylene tube with a maximum outer diameter of 30mm, an inner hole that seals tightly with the outer wall of the opening tube 20, and a length of 5mm. The first film tube 11 can be made with an outer diameter of 12.5mm (excluding the protrusion 111). The height of the convex strip 111 (e.g., 1mm), the length of the 100mm elastomer film tube (e.g., a low surface adhesion and low friction thermoplastic polyurethane film tube), and the thickness (e.g., 0.02mm) are all considered. The actual thickness needs to be determined by combining specific materials to ensure suitable strength, low friction, and flexibility. Furthermore, a lubricating substance can be applied to the outside of the film blind tube 10, or to the inside of the guide member 30 and the opening tube 20, to further reduce the adhesion and friction between the film blind tube 10 and the opening tube 20. The depth of the vent groove 22 can be, for example, 0.5mm. The specific data parameters listed in this embodiment are only illustrative examples of a specific implementation and do not affect the feasibility of selecting other reasonable data parameters. The lower end of the opening tube 20 is used to slide and insert the piston assembly 72 (when the guide member 30 is removed), or to connect the connecting tube 51 or the inflation member. In this embodiment, the opening tube 20, together with the film blind tube 10 and the blocking member 14, forms a closed space to gather air and other gases to obtain the power to push the film blind tube 10 to administer drugs, and also serves as a convenient holding tool.

[0098] Example 2 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 5 , Figure 6The difference from the aforementioned embodiment 1 is that the closed end 13 of the membrane blind tube 10 is connected to the second membrane tube 12, and there is a point break line and a half tangent line between the second membrane tube 12 and the closed end 13 that are easy to break; the inside of the opening tube 20 does not contain the flow guide 30, the outer diameter of the opening tube 20 decreases stepwise from top to bottom, and the lower end of the opening tube 20 is used to connect to the connecting tube 51 or the inflation component by means of plugging or other methods.

[0099] In this embodiment, the length of the second membrane tube 12 can be equal to the length of the opening tube 20; the outer diameter of the section from the upper end of the opening tube 20 to the lower 10mm is 12mm, the outer diameter of the next 5mm section is 11.5mm, and the outer diameter of the remaining section continuing downward is 11mm (optionally, for example, the outer diameter of the lowermost 10mm section can also be 12mm, or a pagoda-shaped connector, i.e., a pagoda head, can be provided at the lower end), with smooth transitions between each section; the inner diameter of the abutment 14 can be, for example, 11.6mm (other options can be implemented to make the abutment 14... The sealing and fixing of the 11.5mm outer diameter section of the opening tube 20 or the transition section between the 11.5mm outer diameter section and the 12mm outer diameter section is also suitable; alternatively, the film blind tube 10 can be formed by a 200mm long soft polyvinyl chloride film tube with low surface adhesion and low friction, which is radially pressure-welded from the middle (with the weld line as the boundary to form a first film tube 11 and a second film tube 12), and a pre-set break line and a half-tangent line at the boundary between the weld line and the second film tube 12. In this embodiment, the second film tube 12 is connected to the stop member 14 through the first film tube 11, and the upper end of the opening tube 20 serves as a fulcrum, jointly used to achieve the function of adjusting the drug delivery depth and / or the position of the closed end.

[0100] Example 3 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 13 , Figure 15 , Figure 16 , Figure 17 , Figure 18 , Figure 19 The difference from the aforementioned embodiment 1 is that the upper end of the opening tube 20 is provided with an inner convex blunt opening 2, and the interior does not contain a flow guide 30; the axial hole of the abutment 14 is slidably sleeved with the outer wall of the opening tube 20, and the abutment 14 is fixedly connected to the open end of the first membrane tube 11 by welding or bonding; the closed end 13 of the membrane blind tube 10 is connected to the second membrane tube 12 and the rod-shaped hook 15, and the outer wall surface of the first membrane tube 11 is not provided with a protrusion 111.

[0101] In this embodiment, the thin-film blind tube 10 is made of a modified polyethylene film tube with low surface adhesion and low friction, and the thickness can be selected, for example, 0.01 mm; the length of the second thin-film tube 12 is greater than the length of the opening tube 20 (for example, the length can be selected as 105 mm); the blocking member 14 can be, for example, a polyethylene or polypropylene plastic tube with a maximum outer diameter of 34 mm and a length of 6 mm; the inner convex blunt end 2 can be treated with a low surface energy coating, micro-nano hydrophobic / oleophobic structure, etc., to further reduce surface adhesion and friction, and the diameter of the inner convex blunt end 2 can be selected as 8 mm; the length of the hook 15 is less than the inner diameter of the opening tube 20 and greater than the diameter of the inner convex blunt end 2 (for example, the hook 15 can be a hard plastic straight rod with a length of 9.5 mm, a diameter of 1.6 mm, and blunt ends). In this embodiment, the opening tube 20 mainly serves to push the wall and hold the device.

[0102] Example 4 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 14 , Figure 15 , Figure 20 , Figure 21 , Figure 22 , Figure 23 The difference from the aforementioned embodiment 3 is that a plug 16 is fixedly and sealed between the first membrane tube 11 and the second membrane tube 12 to form a closed end 13, and an annular protrusion 161 is provided radially on the outer wall of the plug 16 to replace the function of the hook 15.

[0103] As in Embodiments 2, 3, and 4 above, when the drug 1 is pre-placed in the first film tube 11, or when there is no need to adjust the position of the closed end 13 in the open tube 20, the second film tube 12 (i.e., the pull member) may not be provided.

[0104] Example 5 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 12 , Figure 24 , Figure 25 The difference from the aforementioned embodiment 1 is that a wing 24 is fixedly connected to the lower outer part of the opening tube 20, and the opening tube 20 does not contain a guide 30, but is slidably inserted with a blunt tube 40; the blunt tube 40 is a tube body with an inwardly convex blunt end 2 at the upper end and a hole 3 (the hole 3 is located at the lower end and / or side wall) at the lower part, the length of the blunt tube 40 is greater than or equal to 1.5 times the length of the opening tube 20, and the upper end and inner side of the blunt tube 40 are in contact with the outer wall of the first membrane tube 11; the closed end 13 of the first membrane tube 11 is connected to a rod-shaped hook 15, the outer wall surface of the first membrane tube 11 does not have a protrusion 111, and the first membrane tube 11 is made of a modified polyethylene membrane tube with low surface adhesion and low friction, and the thickness can be selected, for example, 0.01 mm.

[0105] In this embodiment, the blunt-mouth tube 40 has an inner diameter of 8.5 mm and a length of 205 mm; the inner convex blunt mouth 2 has a diameter of 7.5 mm; the hook 15 can be a straight hard plastic rod with a length of 8.1 mm, a diameter of 1.6 mm, and blunt ends; the wing 24 has an outer diameter of 36 mm and a thickness of 1.8 mm.

[0106] Example 6 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 5 , Figure 6 , Figure 7 , Figure 26 The difference from the aforementioned embodiment 2 is that the inner wall of the opening tube 20 is provided with a ventilation groove 22; the second membrane tube 12 connected to the closed end 13 of the first membrane tube 11 is replaced by a pull rope 5; the outer wall surface of the first membrane tube 11 is not provided with a protrusion 111; the first membrane tube 11 is made of a modified polyethylene membrane tube with low surface adhesion and low friction, and the thickness can be selected, for example, 0.01 mm.

[0107] Example 7 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 7 , Figure 26 , Figure 27 , Figure 28 The difference from the aforementioned embodiment 6 is that the lower end of the pull rope 5 is fixedly connected to a sealing plug 60, and a connector 61 is connected to the sealing plug 60. The sealing plug 60 can be detachably sealed to the lower opening of the opening tube 20 by means of plugging or threading. The connector 61 is used to connect the connecting tube 51 or the inflation component.

[0108] In embodiments 6 and 7 above, the length of the pull rope 5 is greater than or equal to 1.5 times the length of the opening tube 20, for example, the length can be selected as 205mm. Furthermore, the shape of the pull rope 5 is set as a spring.

[0109] Example 8 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 1 , Figure 2 , Figure 29 The difference from the aforementioned embodiment 1 is that the opening pipe 20 is the front section (i.e. Figure 29The upper section is a reducing pipe with a smaller diameter than the middle and lower sections. Further, a groove for engaging the stopper 14 can be provided at the front of the opening pipe 20. A wing 24 is connected to the lower part of the outer wall of the opening pipe 20. A piston assembly 72 (composed of a piston head 722 and one end of a piston rod 721) is slidably sealed inside the opening pipe 20. In this embodiment, the outer diameter of the stopper 14 can be selected as small as possible (for example, an elastic seal ring such as silicone with an inner diameter of 7mm, a maximum outer diameter of 12mm, and a cross-sectional shape of D can be selected) to minimize the degree of protrusion. The stopper 14 is only used to fix and seal the opening end of the first membrane tube 11 to the opening pipe 20. When the opening pipe 20 is selected with a tube body 21 of the same diameter, the stopper 14 is also used to limit the depth of the opening pipe 20 into the vagina. At this time, the outer diameter of the stopper 14 is preferably significantly larger than the outer diameter of the opening pipe 20. Furthermore, a hole 3 can be provided on the side wall of the opening pipe 20, and an elastic short pipe 6 that seals and covers the hole 3 can be fitted over the opening pipe 20 to form a pressure relief valve structure.

[0110] Example 9 of the push-wall type film-flipping drug delivery device 100 provided by the present invention, see [link to example]. Figure 29 , Figure 30 The difference from Embodiment 8 is that the upper section (i.e., the small-diameter section) of the opening pipe 20 is provided with a ventilation groove 22 on its inner wall; the outer wall of the first membrane tube 11 is not provided with a protrusion 111, and the first membrane tube 11 can be made of a modified polyethylene membrane tube with a thickness of, for example, 0.01 mm; a pull rope 5 is connected between the piston head 722 and the closed end 13 of the first membrane tube 11. Obviously, it is also feasible to choose a pipe body 21 of equal diameter for the opening pipe 20 described in this embodiment and Embodiment 8.

[0111] The method of using the push-wall type film-flipping drug delivery device 100 provided by the present invention in Example 1:

[0112] S1. Place or inject drug 1 into the membrane blind tube 10 (this step can be omitted if it has been pre-inserted), see [link to instructions]. Figure 2 ;

[0113] S2. The lower end of the opening tube 20 is connected to an inflation component (such as an inflation ball 50 or a syringe assembly 70) via a connecting tube 51. See [link / reference]. Figure 7 ;

[0114] S3. The operator holds the opening tube 20 with one hand and pushes the upper end (i.e., the front end) into the patient's vaginal opening until it contacts the vulva above the stopper 14. With the other hand, the operator slowly applies force to the inflation component (e.g., squeezing the inflation ball 50 or pushing the piston rod 721). During this process, air is forced from the inflation component through the connecting tube 51 into the lower part of the opening tube 20, then flows through the air groove 22 and the outer wall of the membrane blind tube 10. Due to the restriction of the vaginal wall, the inflated air continuously accumulates between the upper part of the opening tube 20 and the outer wall of the membrane blind tube 10. Because the opening end of the membrane blind tube 10 is limited by the stopper 14, the inflated air gradually pushes the membrane blind tube 10 until the membrane wall continuously everts and contacts the vaginal wall. Simultaneously, the closed end 13 continuously moves deeper into the vagina. See [link to relevant documentation]. Figure 3 (Until a sudden, noticeable resistance is felt (when there is no pressure relief valve 4) or pressure relief valve 4 begins to release air (at this point, the membrane blind tube 10 is completely everted, the closed end 13 moves to its end, and the medication 1 is delivered deep into the vagina, see...) Figure 4 );

[0115] S4. Release the pressure on the inflatable ball 50 or pull outward on the piston rod 721 (due to the adsorption and friction between the surface of the membrane blind tube 10 in contact with the vaginal wall and the vaginal wall, the protrusion 111 on the outer wall of the first membrane tube 11 supports the air gap formed between the outer wall surfaces of the first membrane tube 11. During this process, the negative pressure formed first continuously attracts and pulls the closed end 13 outward, and the first membrane tube 11 gradually moves out of the vagina from the closed end 13 and finally moves into the opening tube 20), until the inflatable ball 50 or piston assembly 72 is completely reset (at this time, the part of the membrane blind tube 10 that extended into the opening tube 20 during the drug administration process is retracted back into the opening tube 20, see Figure 2 The invention can be removed once only a small amount of residual drug 1 remains inside the first membrane tube 11.

[0116] The specific preset operating pressure of the pressure relief valve 4 is determined by the specific material, wall thickness, and specific processing measures (such as lubrication and surface treatment) of the components in the final physical object of the present invention. The final pressure is further selected based on actual measurements. The standard is that the preset operating pressure can completely turn the first diaphragm tube 11 outward without breaking or severely deforming the first diaphragm tube 11.

[0117] The method of using the push-wall type film-flipping drug delivery device 100 provided by the present invention in Embodiment 2:

[0118] If drug 1 has already been administered or injected, see [link to relevant documentation]. Figure 6 Then you can pull down the second membrane tube 12, or you don't need to connect the second membrane tube 12 or other pullers to the closed end 13. Then you can operate according to S2 to S4 in the above embodiment 1.

[0119] If the first membrane tube 11 is not pre-filled with drug 1, and it is inconvenient to place or inject drug 1 into the depth of the first membrane tube 11, one hand can hold the lower part of the opening tube 20, and the other hand can push down the stop member 14 to make the first membrane tube 11 turn outward until the closed end 13 moves upward from the inside of the opening tube 20 to a suitable depth (for example, the closed end 13 is 20mm away from the upper port of the opening tube 20, that is, the lower end of the stop member 14 moves to the 2cm mark 23 on the outer wall of the opening tube 20). Then, drug 1 can be placed or injected into the first membrane tube 11, and then the second membrane tube 12 is pulled down to the end (during this process, the stop member 14 moves upward along the outside of the opening tube 20 and finally locks in the initial position). See Figure 6 Then pull down and remove the second membrane tube 12; then follow the steps S2 to S4 in Example 1 above.

[0120] The method of using the push-wall type film-flipping drug delivery device 100 provided by the present invention in Example 3:

[0121] S1. Place or inject the drug 1 into the first membrane tube 11 (this step can be omitted if the drug 1 has been pre-placed, and there is no need to connect the second membrane tube 12 or other pull-out components to the closed end 13). See [link to documentation]. Figure 16 ;

[0122] S2. The operator holds the lower part of the opening tube 20, with the upper end of the opening tube 20 facing the patient's vaginal opening, and then slowly pushes it into the patient's vagina (during this process, the upper part of the stop 14 rests against the patient's vulva, and the front end of the opening tube 20 pushes forward against the outer wall of the first membrane tube 11. Since the stop 14 is fixedly connected to the open end of the first membrane tube 11 and does not move, the closed end 13 of the first membrane tube 11 carrying the drug 1 moves out of the opening tube 20. As the first membrane tube 11 continues to turn outward, the closed end 13 carrying the drug 1 gradually moves into the depth of the vagina) until suddenly there is a noticeable resistance (at this time, the first membrane tube 11 is fully turned outward, the two ends of the hook 15 contact the inner convex blunt end 2 of the upper end of the opening tube 20, the closed end 13 moves to the end, and the drug 1 is delivered to the depth of the vagina, see Figure 17 );

[0123] S3. Pull out the opening tube 20, and gradually pull the first membrane tube 11 outward and inward from the closed end 13 to remove it from the vagina, thus removing the invention. (During the process of pulling out the opening tube 20, the inner convex blunt end 2 at the upper end of the opening tube 20 clamps both ends of the rod-shaped hook 15, realizing the pulling outward of the rod-shaped hook 15, thereby gradually pulling the closed end 13 connected to the hook 15 outward and removing it from the vagina. While the closed end 13 is gradually removed from the vagina, the first membrane tube 11 is continuously pulled out of the vagina from the closed end 13 by inward turning. See [link to documentation]). Figure 18 , Figure 19Because the inner surface of the first membrane tube 11 in contact with the vaginal wall has an adhesive force or adhesion to the vaginal wall, and because of the obstruction of the side wall of the opening tube 20, during the process of pulling the opening tube 20 out of the vagina, the opening tube 20 gradually pulls the closed end 13 out of the vagina through the external pull hook 15, and the first membrane tube 11 continuously turns inward and is finally moved out of the vagina.

[0124] If the first membrane tube 11 is not pre-filled with drug 1, and it is inconvenient to place or inject drug 1 deep into the first membrane tube 11, one hand can hold the lower part of the opening tube 20, and the other hand can push down the stop 14 to make the first membrane tube 11 turn outward until the closed end 13 moves upward from the inside of the opening tube 20 to a suitable depth (see the relevant operation method of the above embodiment 2). Then, drug 1 can be placed or injected into the first membrane tube 11. Then, the second membrane tube 12 is pulled down to the target drug delivery depth (that is, the lower end of the stop 14 moves to the target scale mark 23 aligned with the outer wall of the opening tube 20. Of course, the position of drug 1 in the opening tube 20 can also be seen through the opening tube 20. The distance from the closed end 13 to the upper port of the opening tube 20 is basically the same as the depth to which drug 1 will be inserted into the vagina). See Figure 15 , Figure 16 Then proceed with the steps S2 to S3 described in this embodiment.

[0125] The method of using the push-wall type membrane-flipping drug delivery device 100 in Embodiment 4 provided by the present invention is the same as that in Embodiment 3 above. The subtle difference is that in S3, during the process of pulling outwards through the opening tube 20, the inner convex blunt opening 2 at the upper end of the opening tube 20 engages with the protrusion 161 on the outer wall of the plug 16, thereby pulling outwards through the protrusion 161 and gradually flipping the membrane blind tube 10 inwards from the plug 16 end out of the vagina. See [link to documentation]. Figure 15 , Figure 20 , Figure 21 , Figure 22 , Figure 23 .

[0126] The method of using the push-wall type film-flipping drug delivery device 100 in Embodiment 5 of the present invention differs from the method of using it in Embodiment 1 above in that the air-driven drug delivery method in Embodiment 1 is replaced by a method of driving the drug delivery using a blunt-tipped tube 40 that is slidably inserted into the opening tube 20. Specifically...

[0127] S1. Drug 1 is placed or injected into the first membrane tube 11. (See below) Figure 25 ;

[0128] S2. The operator holds the opening tube 20 and / or the blunt tube 40, with the upper end of the opening tube 20 facing the patient's vaginal opening, and pushes the upper end of the opening tube 20 into the patient's vaginal opening until it contacts the patient's vulva on the stop 14. Then, the operator slowly pushes the blunt tube 40 as if using a regular syringe (during this process, since the open end of the stop 14 connected to the first membrane tube 11 remains stationary outside the upper part of the opening tube 20, the front end of the blunt tube 40 pushes forward against the outer wall of the first membrane tube 11, which can drive the closed end 13 to carry the drug 1 out of the blunt tube 40. As the first membrane tube 11 is continuously turned outward, the closed end 13 carrying the drug 1 gradually moves into the depth of the vagina), until suddenly there is a noticeable resistance (at this time, the two ends of the hook 15 contact the inner convex blunt end 2 of the upper end of the blunt tube 40, the closed end 13 moves to the end, and the first membrane tube 11 is fully turned outward and inserted into the deep vaginal administration area, thus delivering the drug 1 to the affected area of ​​the vagina).

[0129] S3. Pull out the blunt-tipped tube 40, and gradually pull the first membrane tube 11 out of the vagina from the closed end 13, thus removing the invention. (During the pulling out of the blunt-tipped tube 40, the inner convex blunt end 2 at the upper end of the blunt-tipped tube 40 engages both ends of the rod-shaped hook 15, thereby pulling the rod-shaped hook 15 outward, and gradually pulling the closed end 13 connected to the hook 15 out of the vagina. Simultaneously, the first membrane tube 11 is continuously pulled out of the vagina from the closed end 13 by turning inward. Because the side of the first membrane tube 11 in contact with the vaginal wall has an adhesive force or adhesion to the vaginal wall, and because of the obstruction of the side wall of the blunt-tipped tube 40, during the process of pulling the blunt-tipped tube 40 out of the vagina, the blunt-tipped tube 40 pulls the closed end 13 connected to the hook 15 by pulling outward, thus gradually turning the first membrane tube 11 inward from the closed end 13 and pulling it out of the vagina.)

[0130] To facilitate the adjustment of the position of the closed end 13 within the blunt-mouthed tube 40, one can refer to Embodiment 2 of the push-wall type flip-film drug delivery device 100 provided by this invention. A second film tube 12 or other pull member is connected below the closed end 13, and an easy-tear line, such as a tear line, is provided between the second film tube 12 and the closed end 13. The second film tube 12 or other pull member extends out from the hole 3 at the lower end of the blunt-mouthed tube 40. Then, the opening tube 20 and the blocking member 14 provided in Embodiment 2 of the push-wall type flip-film drug delivery device 100 are selected. The position of the closed end 13 within the blunt-mouthed tube 40 can be adjusted by pulling down the blocking member 14 and the second film tube 12 respectively. After adjusting the position of the closed end 13 within the blunt-mouthed tube 40 and loading the drug 1, it can be pulled down until the second film tube 12 separates from the closed end 13 at the tear line (at this time, the blocking member 14 has been pulled upwards by the first film tube 11 and is locked in the upper part of the opening tube 20). Then, the operations S2 to S3 described in this embodiment can be performed.

[0131] The method of using the push-wall type membrane drug delivery device 100 in Embodiment 6 provided by the present invention can refer to the method of using the aforementioned Embodiment 2. Since the pull member selected in Embodiment 6 is a pull rope 5, which is much smaller in volume than the second membrane tube 12, it is less likely to obstruct airflow within the opening tube 20. Therefore, it is not necessary to remove the pull rope 5. The difference in the method of use is that when connecting the lower end of the opening tube 20 to the connecting tube 51, the pull rope 5 can be inserted into the lower end of the opening tube 20 or placed into the connecting tube 51 before connecting the lower end of the opening tube 20 to the connecting tube 51. After the first membrane tube 11 is inserted into the vagina to complete the drug delivery, the first membrane tube 11 can be removed from the vagina by pulling the pull rope 5 (i.e., the pull rope 5 pulls the closed end 13 connected to it outwards, and then the closed end 13 pulls the first membrane tube 11 from the closed end 13, continuously turning it inwards until it is finally pulled out of the vagina). See [link to previous section]. Figure 6 , Figure 7 , Figure 26 .

[0132] The method of using the push-wall type film-flipping drug delivery device 100 provided by the present invention differs from that of the aforementioned embodiment 6 in that the lower end of the opening tube 20 is not directly connected to one end of the connecting tube 51. Instead, the pull rope 5 is first inserted into the lower end of the opening tube 20 or placed into the sealing plug 60, and then the upper opening of the sealing plug 60 is detachably connected (e.g., by threaded connection or insertion connection) to the lower end of the opening tube 20. Then, the connector 61 on the sealing plug 60 is inserted into the port end of the syringe assembly 70 (which can be replaced by an elastic inflatable ball). See [link to relevant documentation]. Figure 27 , Figure 28 .

[0133] The method of using the push-wall type film-flipping drug delivery device 100 provided by the present invention in Example 8;

[0134] S1. Place or inject drug 1 into the membrane blind tube 10 (this step can be omitted if it has been pre-inserted), see [link to instructions]. Figure 29 ;

[0135] S2. The operator holds the opening tube 20 with one hand and pushes the upper end (i.e., the front end) into the patient's vaginal opening until the abutment surface 2111 of the large diameter section of the opening tube 20 contacts the patient's vulva. With the other hand, the operator slowly pushes the piston rod 721 forward. (During this process, the volume of the inner cavity of the opening tube 20 decreases, the air is compressed and the air pressure increases. Due to the restriction of the vaginal wall, the air in the opening tube 20 pushes the first membrane tube 11 until the membrane wall continuously flips outward and contacts the vaginal wall. At the same time, the closed end 13 continuously moves deeper into the vagina.) The air in the opening tube 20 leaks out between the elastic body short tube 6 and the outer wall of the opening tube 20. (At this time, the first membrane tube 11 is completely flipped outward, the closed end 13 moves to the end, and the drug 1 is delivered to the depth of the vagina.)

[0136] S3. Pull out the piston rod 721 (increase the volume of the inner cavity of the opening tube 20 and decrease the air pressure) until it is reset (at this time, the part of the first membrane tube 11 that was inserted into the vagina during the drug administration process will be turned inward and retracted into the opening tube 20 under the action of negative pressure), and the front end of the opening tube 20 can be pulled out of the vaginal opening, thereby removing the present invention.

[0137] The method of using the push-wall type membrane dispensing device 100 in Embodiment 9 of the present invention differs from that in Embodiment 8 above in that, after pulling the piston rod 721 outward to the removal tube body 21, the pull rope 5 is continued to pull the first membrane tube 11 out of the vagina and back into the tube body 21 (during this process, the pull rope 5 pulls the closed end 13 inward continuously and retracts it back into the opening tube 20), thus pulling the front end of the opening tube 20 out of the vaginal opening and removing the present invention. See [link to previous section]. Figure 30 .

[0138] For embodiments (e.g., embodiments 2, 3, and 4) in which the stopper 14 is slidably sleeved onto the outer periphery of the opening tube 20, in general, without the second membrane tube 12 or other pulling member, the closed end 13 can be raised by moving the stopper 14 downwards, and the drug 1 can be added into the first membrane tube 11, and the stopper 14 can be pushed upwards to move the closed end 13 downwards (during this process, shaking the opening tube 20 at the same time helps to promote the downward movement of the closed end 13), thereby achieving the adjustment of the position of the closed end 13 within the opening tube 20.

[0139] When using this invention in clinical practice, it is required to clean hands and vulva, follow the standard operating procedure (it is recommended to use the supine position with legs bent or the lithotomy position), and deliver the medication to the posterior fornix of the vagina (the depth of administration is about 5-8 cm). At the same time, attention should be paid to the timing of administration (best before bedtime) and the prohibition of administration during menstruation.

[0140] In general, this invention is also applicable to low-irritation drug administration or insertion / exit operations in other natural cavities and artificial cavities of the human body and other organisms. For specific usage, please refer to the aforementioned content on intravaginal drug administration.

[0141] The above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation of the present invention. Those skilled in the art can make other variations or modifications based on the above description. It is impossible to exhaustively list all possible implementations here. All obvious variations or modifications derived from the technical solutions of the present invention are still within the protection scope of the present invention.

Claims

1. A push-wall type film-flipping drug delivery device, characterized in that: It includes a thin-film blind tube (10) and an open tube (20). The closed end (13) of the thin-film blind tube (10) extends into the open tube (20). The open end of the thin-film blind tube (10) is connected to a stop (14). The stop (14) is connected to or in contact with the open tube (20). At least in the initial state, the upper end of the open tube (20) is away from the closed end (13).

2. The push-wall type film-flipping drug delivery device as described in claim 1, characterized in that: The upper outer diameter of the opening pipe (20) is greater than the outer diameter of the middle and lower parts; or the upper outer diameter of the opening pipe (20) is smaller than the outer diameter of the middle and lower parts.

3. The push-wall type film-flipping drug delivery device as described in claim 1, characterized in that: The closed end (13) is connected to a pull member.

4. The push-wall type film-flipping drug delivery device as described in claim 1, characterized in that: The stopper (14) has a gap (141).

5. The push-wall type film-flipping drug delivery device as described in any one of claims 1 to 4, characterized in that: The upper end of the opening tube (20) is provided with an inner convex blunt opening (2); the closed end (13) is connected to a hook (15).

6. The push-wall type film-flipping drug delivery device as described in any one of claims 1 to 4, characterized in that: The opening tube (20) is fitted with a piston assembly (72) in a sliding seal; or the lower part or side of the opening tube (20) is connected to a connecting tube (51) and / or connected to an inflation component.

7. The push-wall type film-flipping drug delivery device as described in claim 6, characterized in that: The inner wall of the opening pipe (20) is connected to a guide (30), or the inner diameter of the section of the connecting pipe (51) away from the opening pipe (20) becomes smaller, or the inner diameter of the connecting pipe (51) is larger than the inner diameter of the air outlet of the inflation component.

8. The push-wall type film-flipping drug delivery device as described in claim 7, characterized in that: The inner wall of the opening pipe (20) and / or the outer wall of the guide (30) are provided with ventilation grooves (22).

9. The push-wall type film-flipping drug delivery device as described in any one of claims 1 to 4, characterized in that: The outer wall of the thin-film blind tube (10) is provided with a protrusion (111) for supporting the formation of the ventilation gap.

10. The push-wall type film-flipping drug delivery device as described in claim 3, characterized in that: The lower end of the pull member is connected to a sealing plug (60), and a connector (61) is connected to the sealing plug (60). The sealing plug (60) is detachably and sealably connected to the lower opening of the opening tube (20).

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