Detector for multiphase liquid chromatograph

Abstract

A detector for a multiphase liquid chromatograph comprises a mounting base, the multiphase liquid chromatograph is fixed to the mounting base, a mounting support is fixed to the rear side of the mounting base, a sliding groove is formed in the mounting support, the cross section of the sliding groove is in a convex shape, a sliding support is slidably connected into the sliding groove, and an isolation sleeve is glued to the lower side of the sliding support. The isolation sleeve can be folded, the lower side of the isolation sleeve adheres to the installation base, a threaded barrel is fixed to the sliding support, a threaded rod is rotationally connected between the installation base and the installation support, the threaded rod is in threaded connection with the threaded barrel, and the threaded rod is driven by a motor. Due to the fact that the flexible foldable isolation sleeve is arranged on the periphery of the detector for the multi-phase liquid chromatograph, when the detector is used, a semi-closed microenvironment can be formed in the detection cavity only by lifting the sleeve body upwards along the guide rail, physical interference such as airflow, dust, temperature sudden change and external vibration is effectively blocked, and stability and high precision of multi-phase liquid chromatogram signals are guaranteed.

Description

Technical Field

[0001] This invention relates to the technical field of chromatographs, and more specifically to a detector for a multiphase liquid chromatograph. Background Technology

[0002] Multiphase liquid chromatography (HPLC) detectors are high-end analytical tools developed to meet the needs of simultaneous separation and multi-dimensional detection of complex samples. By cascading detectors based on various principles, such as UV, FLD, CAD, and MS, into the end of a traditional HPLC system, they can obtain multiple parameters, including retention time, spectrum, charge, and mass-to-charge ratio, in a single run, significantly improving peak capacity and the reliability of qualitative and quantitative analysis. This configuration has been used in drug-related substance screening, natural product component profiling, metabolomics, food safety, and environmental trace pollutant monitoring, achieving end-to-end data comparability from early-stage R&D to quality control, reducing the need for repeated injections and reliance on standards, and providing a panoramic analytical platform for complex systems.

[0003] According to Chinese Patent No. CN219957477U, a liquid chromatograph for industrial wastewater detection is disclosed. Its structure includes a chromatograph body, a control panel on the front end of the chromatograph body, a storage cylinder embedded in the top of the chromatograph body, and a liquid injection component movably embedded in the storage cylinder. The liquid injection component has an injection port on one side and adopts an electrically retractable injection port structure, which has the advantages of dust prevention and improved ease of use. In use, operating the control panel causes the linear actuator to drive the slider upwards. The slider causes the liquid injection component to extend out of the storage cylinder, and the telescopic pipe stretches and deforms, exposing the injection port. The operator can then align the injector with the injection port and inject the trace amount of industrial wastewater to be detected into the flow channel, which then enters the chromatographic column through the telescopic pipe for detection.

[0004] However, existing detectors used in multiphase liquid chromatographs are susceptible to external physical factors (such as temperature fluctuations, electromagnetic interference, and airflow disturbances) during the detection phase, which can cause signal drift or increased noise, thereby reducing the accuracy of the detection results and leading to problems such as qualitative misjudgment, quantitative deviation, and peak identification errors. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to overcome the problem that the detector of the existing multiphase liquid chromatograph is easily affected by external physical factors (such as temperature fluctuations, electromagnetic interference and airflow disturbances) during the detection stage, which causes the detection signal to drift or increase noise, thereby reducing the accuracy of the detection results and causing qualitative misjudgment, quantitative deviation and peak identification error.

[0006] The technical solution adopted to solve the above technical problems is: A detector for a multiphase liquid chromatograph includes a mounting base on which a multiphase liquid chromatograph is fixed. A mounting bracket is fixed to the rear side of the mounting base. The mounting bracket has a sliding groove with a convex cross-section. A sliding support is slidably connected within the sliding groove. An isolation sleeve is glued to the lower side of the sliding support. The isolation sleeve is foldable and its lower side is glued to the mounting base. A threaded cylinder is fixed to the sliding support. A threaded rod is rotatably connected between the mounting base and the mounting bracket. The threaded rod is threadedly connected to the threaded cylinder. The threaded rod is driven by a motor, which rotates the threaded rod. The threaded cylinder causes the sliding support to move up and down within the convex sliding groove, allowing the isolation sleeve to fold accordingly. This ensures that the chromatograph is always isolated from the external environment, minimizing dust and airflow interference, reducing baseline noise, and meeting the stable environment requirements of multiphase detection.

[0007] As a preferred embodiment of the present invention, the inner layer of the isolation sleeve is adhesively bonded with a heat insulation-electromagnetic shielding layer. The heat insulation-electromagnetic shielding layer of the isolation sleeve is composed of a flexible multilayer material made of aerogel composite felt or aluminum foil bubble film and conductive fiber cloth by hot pressing. The inner layer of the isolation sleeve adopts a flexible multilayer material of aerogel composite felt + conductive fiber cloth, which has both heat insulation and electromagnetic shielding functions, effectively isolates external heat sources and radio frequency interference, and improves the quantitative accuracy of low concentration samples.

[0008] As a preferred embodiment of the present invention, a miniature variable frequency compressor integrated cooling and heating unit is fixed on the mounting bracket, and an air outlet is opened on the lower side of the miniature variable frequency compressor integrated cooling and heating unit, through which the miniature variable frequency compressor integrated cooling and heating unit delivers constant temperature air into the isolation sleeve.

[0009] As a preferred embodiment of the present invention, a support base is fixed to the lower side of the mounting base, and the number of the support bases is four. A control panel is mounted on the mounting base.

[0010] As a preferred embodiment of the present invention, a threaded telescopic rod is rotatably connected to the mounting base, a telescopic base is threadedly connected to the threaded telescopic rod, a limit hole is opened on the telescopic base, a limit rod is fixed on the mounting base, the limit rod slides within the limit hole of the telescopic base, and the threaded telescopic rod is driven by a motor.

[0011] As a preferred embodiment of the present invention, a spring buffer rod is fixed on the telescopic base, and a multi-phase liquid chromatograph is fixed on the spring buffer rod. The spring buffer rod forms a "floating support" between the telescopic base and the chromatograph, which can absorb vertical vibrations and avoid interference from pump pulses and external vibrations on the detector optical path.

[0012] The beneficial effects of this invention are as follows: Because this invention features a flexible, foldable isolation sleeve around the detector of a multiphase liquid chromatograph, during use, simply pulling the sleeve upwards along the guide rail creates a semi-closed microenvironment in the detection chamber, effectively blocking physical interferences such as airflow, dust, temperature changes, and external vibrations, thus ensuring the stability and high precision of the multiphase liquid chromatographic signal. Attached Figure Description

[0013] Figure 1 This is a first axial view of the present invention; Figure 2 for Figure 1 A magnified view of part A; Figure 3 This is a second axial view of the present invention; Figure 4 This is the third axial view of the present invention.

[0014] In the diagram: 1. Mounting base; 2. Multiphase liquid chromatograph; 3. Mounting bracket; 4. Sliding groove; 5. Sliding bracket; 6. Isolation sleeve; 7. Threaded cylinder; 8. Threaded rod; 9. Miniature variable frequency compressor integrated cooling and heating unit; 10. Air outlet; 11. Support base; 12. Control panel; 13. Threaded telescopic rod; 14. Telescopic base; 15. Limiting rod; 16. Spring buffer rod. Detailed Implementation

[0015] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. The components of the embodiments of the present invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0016] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0017] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0018] In the above description of the present invention, it should be noted that the terms "one side," "the other side," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the product of the invention is conventionally placed during use. These terms are used only for the convenience of describing the present invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention. Furthermore, the terms "first," "second," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance.

[0019] Furthermore, terms such as "identical" do not imply that components must be absolutely identical; minor differences are permissible. The term "perpendicular" simply means that the positional relationship between components is more perpendicular than "parallel," not that the structure must be perfectly perpendicular; a slight tilt is acceptable.

[0020] Example 1

[0021] exist Figure 1-4 This invention provides a technical solution: a detector for a multiphase liquid chromatograph, including a mounting base 1, on which a multiphase liquid chromatograph 2 is fixed. A mounting bracket 3 is fixed to the rear side of the mounting base 1. A sliding groove 4 is formed on the mounting bracket 3, and the cross-section of the sliding groove 4 is convex. A sliding support 5 is slidably connected within the sliding groove 4. An isolation sleeve 6 is glued to the lower side of the sliding support 5. The isolation sleeve 6 is foldable and glued to the mounting base 1. A threaded cylinder 7 is fixed to the sliding support 5. A threaded rod 8 is rotatably connected between the mounting base 1 and the mounting bracket 3. The threaded rod 8 is threadedly connected to the threaded cylinder 7. The threaded rod 8 is driven by a motor. The motor drives the threaded rod 8 to rotate, and the threaded cylinder 7 drives the sliding support 5 to rise and fall along the convex sliding groove 4. The folded isolation sleeve 6 extends and retracts accordingly, forming an adjustable barrier around the detection area to isolate external airflow and dust, ensuring a clean working environment for the multiphase liquid chromatograph 2.

[0022] In one aspect of this embodiment, the inner layer of the isolation sleeve 6 is adhesively bonded with a heat-insulating and electromagnetic shielding layer. The heat-insulating and electromagnetic shielding layer of the isolation sleeve 6 is composed of a flexible multilayer material made of aerogel composite felt or aluminum foil bubble film and conductive fiber cloth by hot pressing. The flexible multilayer material simultaneously blocks heat transfer and electromagnetic interference, reduces the impact of ambient temperature fluctuations and radio frequency noise on the detection signal, and improves detection stability and repeatability.

[0023] In one aspect of this embodiment, a miniature variable frequency compressor integrated cooling and heating unit 9 is fixed on the mounting bracket 3. An air outlet 10 is opened on the lower side of the miniature variable frequency compressor integrated cooling and heating unit 9. The miniature variable frequency compressor integrated cooling and heating unit 9 delivers constant temperature airflow to the detection area through the air outlet 10, quickly adjusts the temperature inside the isolation cover, makes the detector work in the optimal temperature range, and reduces baseline fluctuations caused by thermal drift.

[0024] In one aspect of this embodiment, a support base 11 is fixed to the lower side of the mounting base 1, and there are four support bases 11. A control panel 12 is mounted on the mounting base 1. A threaded telescopic rod 13 is rotatably connected to the mounting base 1, and a telescopic base 14 is threadedly connected to the threaded telescopic rod 13. A limit hole is opened on the telescopic base 14, and a limit rod 15 is fixed on the mounting base 1. The limit rod 15 slides in the limit hole of the telescopic base 14. The threaded telescopic rod 13 is driven by a motor, and a spring buffer rod 16 is fixed on the telescopic base 14. A multi-phase liquid chromatograph 2 is fixed on the spring buffer rod 16. The motor drives the threaded telescopic rod 13 to rotate, and the telescopic base 14 is vertically raised and lowered under the guidance of the limit rod 15, realizing stepless adjustment of the detector height. The spring buffer rod 16 absorbs equipment vibration and forms a three-point elastic support with the support base 11, reducing the interference of external vibration on the detection accuracy and completing the integrated adjustment of height, vibration isolation and shielding.

[0025] The working principle of this invention is as follows: The motor drives the threaded rod 8 to rotate, causing the threaded cylinder 7 to move the sliding support 5 up and down along the convex sliding groove 4. The folding isolation sleeve 6 extends and retracts accordingly, forming an adjustable barrier around the detection area. Its inner heat insulation-electromagnetic shielding layer blocks heat transfer and electromagnetic interference, ensuring a clean and low-noise working environment for the multi-phase liquid chromatograph 2. The micro-frequency variable compressor integrated heating and cooling unit 9 delivers constant-temperature airflow into the isolation cover through the air outlet 10, quickly adjusting the temperature to the optimal range and reducing thermal drift. At the same time, the motor drives the threaded telescopic rod 13 to rotate, causing the telescopic base 14 to rise and fall vertically under the guidance of the limit rod 15, realizing stepless adjustment of the detector height. The spring buffer rod 16 absorbs equipment vibration and, together with the support base 11, forms a three-point elastic support, reducing the impact of external vibration on detection accuracy. Thus, the integrated operation of the logical sequence of "barrier adjustment - constant temperature control - height adjustment - vibration isolation support" is completed, ensuring the stability and accuracy of the multi-phase liquid chromatograph detection.

[0026] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A detector for a multiphase liquid chromatograph, comprising a mounting base (1), characterized in that: A multi-phase liquid chromatograph (2) is fixed on the mounting base (1). A mounting bracket (3) is fixed on the rear side of the mounting base (1). A sliding groove (4) is opened on the mounting bracket (3). The cross-section of the sliding groove (4) is convex. A sliding bracket (5) is slidably connected in the sliding groove (4). An isolation sleeve (6) is glued to the lower side of the sliding bracket (5). The isolation sleeve (6) is foldable. The lower side of the isolation sleeve (6) is glued to the mounting base (1). A threaded cylinder (7) is fixed on the sliding bracket (5). A threaded rod (8) is rotatably connected between the mounting base (1) and the mounting bracket (3). The threaded rod (8) is threadedly connected to the threaded cylinder (7). The threaded rod (8) is driven by a motor.

2. The detector for a multiphase liquid chromatograph according to claim 1, characterized in that: The inner layer of the isolation sleeve (6) is glued with a heat insulation-electromagnetic shielding layer. The heat insulation-electromagnetic shielding layer of the isolation sleeve (6) is composed of a flexible multilayer material made of aerogel composite felt or aluminum foil bubble film and conductive fiber cloth by hot pressing.

3. The detector for a multiphase liquid chromatograph according to claim 1, characterized in that: The mounting bracket (3) is fixed with a micro variable frequency compressor integrated cooling and heating unit (9), and the mounting bracket (3) has an air outlet (10) on the lower side of the micro variable frequency compressor integrated cooling and heating unit (9).

4. The detector for a multiphase liquid chromatograph according to claim 1, characterized in that: The mounting base (1) has a support seat (11) fixed on its lower side. There are four support seats (11). A control panel (12) is installed on the mounting base (1).

5. A detector for a multiphase liquid chromatograph according to claim 4, characterized in that: A threaded telescopic rod (13) is rotatably connected to the mounting base (1), and a telescopic base (14) is threadedly connected to the threaded telescopic rod (13). A limit hole is opened on the telescopic base (14), and a limit rod (15) is fixed on the mounting base (1). The limit rod (15) slides in the limit hole of the telescopic base (14), and the threaded telescopic rod (13) is driven by a motor.

6. A detector for a multiphase liquid chromatograph according to claim 5, characterized in that: A spring buffer rod (16) is fixed on the telescopic base (14), and a multi-phase liquid chromatograph (2) is fixed on the spring buffer rod (16).

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