Vascularized flaps and methods of making the same

CN122031776BActive Publication Date: 2026-06-23WUHAN TEXTILE UNIV +1
View PDF 2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN TEXTILE UNIV
Filing Date
2026-04-14
Publication Date
2026-06-23

AI Technical Summary

Technical Problem

Traditional flap transplantation relies on the patient's own donor site, which has problems such as donor site damage, limited tissue volume, and low morphological matching. In addition, the connection stability between artificial blood vessels and muscle tissue is not good, and displacement, detachment, or poor adhesion are prone to occur, resulting in insufficient blood supply to the central area of ​​the flap after implantation, leading to ischemic necrosis.

Method used

By cooling muscle tissue to create openings, implanting contracted artificial blood vessels and expanding them, combined with decellularization to create an interference fit, the connection strength between the artificial blood vessels and muscle tissue is enhanced. Biodegradable materials and bioactive coatings are used to promote the ingrowth of new blood vessels.

Benefits of technology

It improved the survival rate of skin flap transplantation, reduced the risk of ischemic necrosis, enhanced the connection stability between artificial blood vessels and muscle tissue, promoted the vascularization process, formed a tight mechanical interlock and localized densification area, and improved the biocompatibility and mechanical support of vascularized skin flaps.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122031776B_ABST
    Figure CN122031776B_ABST
Patent Text Reader

Abstract

The application provides a vascularized skin flap and a preparation method thereof, and belongs to the field of tissue engineering materials. The preparation method comprises the following steps: providing muscle tissue and an artificial blood vessel. The muscle tissue is subjected to cooling treatment, and the cooled muscle tissue is subjected to hole opening treatment to obtain a first structure. The artificial blood vessel is subjected to shrinkage treatment, and the shrunk artificial blood vessel is implanted into the hole of the first structure to obtain a second structure. The artificial blood vessel in the second structure is subjected to expansion treatment to obtain a third structure. The third structure is subjected to decellularization treatment to obtain the vascularized skin flap. The outer diameter of the artificial blood vessel is greater than the inner diameter of the hole. The technical scheme can improve the connection stability of the artificial blood vessel and the muscle tissue, further promote the growth of new blood vessels and the vascularization process of the vascularized skin flap, improve the survival rate of skin flap transplantation, and thus improve the vascularization effect of the vascularized skin flap.
Need to check novelty before this filing date? Find Prior Art