Full-automatic nucleic acid extraction and amplification detection system based on centrifugal microfluidics
The fully automated nucleic acid extraction, amplification, and detection system based on centrifugal microfluidics integrates sample lysis, nucleic acid extraction, purification, amplification, and detection into a single microfluidic chip, solving the problems of cumbersome operation, contamination risk, and complex equipment in existing technologies, and achieving rapid, accurate, and low-cost automated detection.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-02-02
- Publication Date
- 2026-05-15
AI Technical Summary
Existing technologies for nucleic acid extraction and amplification detection suffer from problems such as high laboratory construction costs, aerosol contamination risks, large equipment size, and complex cartridge designs, resulting in cumbersome operations and difficulty in achieving rapid, accurate, and low-cost automated detection.
A fully automated nucleic acid extraction, amplification, and detection system based on centrifugal microfluidics is adopted, which integrates sample lysis, nucleic acid extraction, purification, amplification, and detection functions into a single microfluidic chip. Utilizing a magnet switching device and a magnetic fixation device, combined with an optimized flow channel design and magnetic bead method, it achieves automated operation and in-situ pre-storage of reagents.
It enables rapid, accurate, and low-cost nucleic acid testing, reduces human intervention and error, improves extraction efficiency and purity, reduces the risk of cross-contamination, is suitable for clinical point-of-care testing scenarios, and supports multiple testing needs.
Smart Images
Figure CN122038113A_ABST