Magnetic resonance imaging repeated scanning consistent positioning method, system and terminal based on image guidance

Abstract

The invention provides a magnetic resonance imaging repeated scanning consistent positioning method and system based on image guidance, and a terminal, and is applied to magnetic resonance scanning positioning to obtain a low-resolution reference guidance image and an initial positioning image used for positioning a region of interest. Collecting a guide image at the current moment, registering the guide image with the low-resolution reference guide image, and calculating a current positioning parameter of the region of interest at the current moment; and based on the current positioning parameter input in real time, the magnetic resonance scanning control system performs main sequence scanning to obtain a current main sequence image. The technical problems that in the prior art, in magnetic resonance imaging, in the field of repeated scanning positioning, fine signals are weakened through post-registration, positioning deviation is caused by body movement, and the imaging efficiency and the imaging effect are difficult to consider at the same time are solved. According to the method, extra hardware support is not needed, and the technical scheme of accurate, efficient and consistent positioning can be realized, so that the high-precision and high-stability requirements of scenes such as early disease diagnosis and longitudinal scientific research tracking on magnetic resonance imaging are met.

Description

Technical Field

[0001] This invention relates to the field of magnetic resonance imaging in medical imaging, and in particular to an image-guided magnetic resonance imaging repetitive scanning coherent localization method, system, and terminal. Background Technology

[0002] Magnetic resonance imaging (MRI), as a mainstream medical imaging technology, has been widely used in scenarios with high requirements for imaging accuracy and safety, such as brain structure imaging, cerebrovascular imaging, and research on nervous system diseases, thanks to its unique advantages of excellent soft tissue contrast, no ionizing radiation damage, and multi-parameter and multi-contrast imaging.

[0003] In medical research and clinical practice, many diseases exhibit latent and gradual development, with early pathological changes often manifesting only as subtle structural or functional abnormalities. Accurate capture of these subtle signals is crucial for early diagnosis, intervention, and efficacy evaluation. However, most current magnetic resonance imaging studies rely on post-hoc image registration techniques to correct positional deviations for image alignment across different time points and imaging modalities. This post-hoc correction method has inherent technical limitations: the interpolation and smoothing operations performed to achieve image alignment inevitably weaken subtle pathological signals in the images. This leads to the underestimation, blurring, or even omission of weak abnormal signals in early diseases, making it impossible to accurately reconstruct the initial state of the lesion, thus affecting the accuracy of early disease diagnosis and the reliability of research data.

[0004] Meanwhile, traditional MRI scanning protocols, to ensure complete coverage of anatomical regions, typically employ a wide spatial scanning range, coupled with multi-sequence, high-resolution acquisition parameters. This significantly prolongs the overall scanning time, reducing equipment diagnostic efficiency and subject movement. Furthermore, the inclusion of numerous imaging areas unrelated to disease diagnosis or research objectives disperses scanning resources, making it difficult to further improve the signal-to-noise ratio (SNR) of the region of interest (ROI). To address these issues, those skilled in the art have attempted to limit the scanning area and focus imaging on the ROI, thereby shortening acquisition time, improving imaging efficiency, and simultaneously enhancing the SNR and optimizing image quality. However, this approach faces new technical bottlenecks: the determination of the existing scanning area usually relies on the initial localization image and lacks a dynamic correction mechanism. During the intervals between sequential scans, subjects inevitably experience slight movements, causing deviations between the actual scanning area and the pre-defined ROI. This can not only result in incomplete coverage of the expected scanning area but also cause inconsistencies in the imaging area across repeated scans, affecting the stability of the imaging results and further complicating subsequent image analysis, making it difficult to simultaneously meet the dual requirements of imaging efficiency and localization accuracy. Summary of the Invention

[0005] In view of the shortcomings of the prior art described above, the purpose of this invention is to provide an image-guided magnetic resonance imaging repetitive scanning consistent localization method, system and terminal to solve the technical problems in the prior art such as registration weakening of subtle signals, positioning deviation caused by body movement, and difficulty in balancing imaging efficiency and effect.

[0006] To achieve the above and other related objectives, the present invention provides an image-guided magnetic resonance imaging repetitive scanning consistent localization method, the method comprising: acquiring a low-resolution reference guiding image and an initial localization image for locating the region of interest; acquiring the guiding image at the current moment and registering it with the low-resolution reference guiding image, calculating the current localization parameters of the region of interest at the current moment; and controlling the magnetic resonance scanning control system to perform a main sequence scan based on the current localization parameters to obtain the current main sequence image.

[0007] In one embodiment of the present invention, acquiring a low-resolution reference guiding image and an initial positioning image for locating a region of interest includes: acquiring a low-resolution reference guiding image; acquiring an initial positioning image with the same orientation as the low-resolution reference guiding image based on the low-resolution reference guiding image, and obtaining initial positioning parameters for the corresponding region of interest.

[0008] In one embodiment of the present invention, the step of acquiring the current guiding image and registering it with the low-resolution reference guiding image to calculate the current positioning parameters of the region of interest at the current moment includes: acquiring the current guiding image by calling the same imaging sequence parameters as the low-resolution reference guiding image; registering the current guiding image with the low-resolution reference guiding image to obtain motion parameters; and performing spatial transformation calculation by combining the motion parameters with the initial positioning parameters to obtain the current positioning parameters of the region of interest at the current moment.

[0009] In one embodiment of the present invention, registering the current guiding image with the low-resolution reference guiding image to obtain motion parameters includes: performing grayscale normalization processing on the current guiding image and the low-resolution reference guiding image, and obtaining six-degree-of-freedom motion parameters including three translation parameters and three rotation parameters through image spatial position comparison analysis.

[0010] In one embodiment of the present invention, the step of performing spatial transformation calculations by combining the motion parameters with the initial positioning parameters to obtain the current positioning parameters of the region of interest at the current moment includes: superimposing the three translation parameters in the motion parameters with the spatial coordinate parameters in the initial positioning parameters to obtain the position parameters of the region of interest at the current moment; performing angle correction on the three rotation parameters in the motion parameters with the azimuth angle parameters in the initial positioning parameters to obtain the spatial orientation parameters of the region of interest at the current moment; and integrating the position parameters and the spatial orientation parameters to obtain the current positioning parameters of the region of interest at the current moment.

[0011] In one embodiment of the present invention, the step of controlling the magnetic resonance scanning control system to perform main sequence scanning based on the current positioning parameters to obtain the current main sequence image includes: controlling the magnetic resonance scanning control system to synchronously update the current scanning orientation of the region of interest at the current moment in real time based on the current positioning parameters, and controlling the magnetic resonance scanning control system to perform main sequence scanning according to the current scanning orientation to obtain the current main sequence image.

[0012] In one embodiment of the present invention, during the acquisition of the initial positioning image, motion correction technology can be used to adjust the region of interest in the initial positioning image and the low-resolution reference guide image to be aligned in orientation; during the acquisition of the current main sequence image, motion correction technology can be used to adjust the region of interest in the current main sequence image and the guide image at the current moment to be aligned in orientation.

[0013] To achieve the above and other related objectives, the present invention provides an image-guided magnetic resonance imaging repetitive scanning consistent localization system. The system includes: a localization scanning module for acquiring a low-resolution reference guiding image and an initial localization image for locating the region of interest; a registration calculation module for acquiring the guiding image at the current moment, registering it with the low-resolution reference guiding image, and calculating the current localization parameters of the region of interest at the current moment; and a real-time main sequence scanning module for controlling the magnetic resonance scanning control system to perform a main sequence scan based on the current localization parameters to obtain the current main sequence image.

[0014] To achieve the above and other related objectives, the present invention provides a computer program product, which includes computer program code. When the computer program code is run on a computer, the computer implements the image-guided magnetic resonance imaging repetitive scanning consistent localization method.

[0015] To achieve the above and other related objectives, the present invention provides an electronic terminal, comprising: one or more memories and one or more processors; the one or more memories are used to store a computer program; the one or more processors are connected to the memories and are used to run the computer program to execute the image-guided magnetic resonance imaging repetitive scanning coherent localization method.

[0016] As described above, this invention is an image-guided magnetic resonance imaging (MRI) repetitive scanning consistent localization method, system, and terminal, which has the following beneficial effects: This invention is applied to MRI scanning localization, acquiring a low-resolution reference guiding image and an initial localization image for locating the region of interest; acquiring the current guiding image and registering it with the low-resolution reference guiding image to calculate the current localization parameters of the region of interest; based on the real-time input of the current localization parameters, the MRI scanning control system performs the main sequence scan to obtain the current main sequence image. This invention overcomes the technical problems of weakened subtle signals due to post-registration, localization deviation caused by body movement, and difficulty in balancing imaging efficiency and effect in the field of repetitive scanning localization in current MRI technology; this invention provides a technical solution that achieves accurate and efficient consistent localization without additional hardware support, meeting the high precision and high stability requirements of MRI in scenarios such as early disease diagnosis and longitudinal scientific research tracking. Attached Figure Description

[0017] Figure 1 The diagram shown is a flowchart of an image-guided magnetic resonance imaging repetitive scanning coherent localization method according to an embodiment of the present invention.

[0018] Figure 2 The diagram shown is a flowchart illustrating another image-guided magnetic resonance imaging repetitive scanning coherent localization method according to an embodiment of the present invention.

[0019] Figure 3 The diagram shown is a structural schematic of an image-guided magnetic resonance imaging repeat scan coherent localization system according to an embodiment of the present invention.

[0020] Figure 4 The diagram shown is a structural schematic of an electronic terminal according to an embodiment of the present invention. Detailed Implementation

[0021] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that, unless otherwise specified, the following embodiments and features described therein can be combined with each other.

[0022] It should be noted that in the following description, reference is made to the accompanying drawings, which illustrate several embodiments of the invention. It should be understood that other embodiments may also be used, and changes in mechanical composition, structure, electrical system, and operation may be made without departing from the spirit and scope of the invention. The following detailed description should not be considered limiting, and the scope of the embodiments of the invention is defined only by the claims of the published patents. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the invention. Spatially related terms, such as “upper,” “lower,” “left,” “right,” “below,” “below,” “lower part,” “above,” “upper part,” etc., may be used herein to illustrate the relationship between one element or feature shown in the figures and another element or feature.

[0023] Throughout this specification, when it is said that a part is "connected" to another part, this includes not only "direct connection" but also "indirect connection" by placing other elements in between. Furthermore, when it is said that a part "includes" a certain constituent element, unless otherwise stated otherwise, this does not exclude other constituent elements, but rather means that other constituent elements may also be included.

[0024] The terms "first," "second," and "third," etc., used herein are for the purpose of describing various parts, components, regions, layers, and / or segments, but are not limiting. These terms are used only to distinguish one part, component, region, layer, or segment from others. Therefore, the "first part," "component," "region," "layer," or "segment" described below may refer to a "second part," "component," "region," "layer," or "segment" without departing from the scope of this invention.

[0025] Furthermore, as used herein, the singular forms “a,” “an,” and “the” are intended to include the plural forms as well, unless the context indicates otherwise. It should be further understood that the terms “comprising,” “including,” indicate the presence of the stated feature, operation, element, component, item, kind, and / or group, but do not preclude the presence, occurrence, or addition of one or more other features, operations, elements, components, items, kinds, and / or groups. The terms “or” and “and / or” as used herein are interpreted as inclusive, or mean any one or any combination thereof. Thus, “A, B, or C” or “A, B, and / or C” means “any one of: A; B; C; A and B; A and C; B and C; A, B, and C.” Exceptions to this definition arise only when combinations of elements, functions, or operations are inherently mutually exclusive in some manner.

[0026] This invention provides an image-guided consistent localization method for repeated scans in magnetic resonance imaging (MRI). Applied to MRI scan localization, it acquires a low-resolution reference guide image and an initial localization image for locating the region of interest (ROI). The method then acquires the current guide image and registers it with the low-resolution reference guide image, calculating the current localization parameters of the RIO at that moment. Based on the real-time input of these current localization parameters, the MRI scan control system performs the main sequence scan to obtain the current main sequence image. This invention overcomes the technical problems of weakened subtle signals due to post-registration, localization deviations caused by body movement, and the difficulty in balancing imaging efficiency and effectiveness in the field of repeated scan localization in current MRI technology. This invention provides a precise and efficient consistent localization solution without requiring additional hardware support, meeting the high precision and high stability requirements of MRI in scenarios such as early disease diagnosis and longitudinal scientific research tracking.

[0027] The present invention will now be described in detail with reference to the accompanying drawings, so that those skilled in the art can readily implement it. The present invention can be embodied in many different forms and is not limited to the embodiments described herein.

[0028] like Figure 1 This is a flowchart illustrating an image-guided magnetic resonance imaging repetitive scanning consistent localization method according to an embodiment of the present invention.

[0029] The method includes:

[0030] Step S1: Acquire a low-resolution reference guide image and an initial localization image for locating the region of interest.

[0031] In one embodiment, a low-resolution reference guide image is rapidly acquired using a fast scanning sequence, such as a fast gradient echo sequence, carried by the magnetic resonance scanning system. This low-resolution reference guide image does not need to pursue excessively high imaging resolution; its main function is to establish a unified spatial orientation reference for the entire magnetic resonance scanning process, providing a stable reference basis for subsequent registration of the current guide image, calculation of motion parameters, and calibration of the scanning coordinate system.

[0032] Using the low-resolution reference image as the core reference, the scanning field of view is precisely aligned, and the scanning parameters are adjusted to meet the initial imaging requirements of the region of interest (ROI). An initial positioning image is acquired that is consistent with the spatial orientation of the ROI in the low-resolution reference image, ensuring that the initial positioning image can clearly present the initial spatial distribution of the ROI, and that its orientation corresponds to the ROI in the reference image without deviation. Simultaneously, based on the acquired initial positioning image, relevant parameters characterizing the key spatial information of the ROI are extracted and integrated to form the initial positioning parameters of the ROI. These initial positioning parameters include key information such as the initial spatial coordinates of the ROI and the azimuth angle of the scanning plane. They serve as the basic reference for dynamically correcting the current positioning parameters and updating the scanning coordinate system before each subsequent main sequence scan, ensuring that the subsequent scanning process can always carry out accurate imaging around the ROI.

[0033] In one embodiment, motion correction technology can be used during the acquisition of the initial positioning image to ensure that the orientation of the region of interest (ROI) in the initial positioning image is consistent with that in the low-resolution reference guide image. Specifically, during the acquisition of the initial positioning image, motion correction technology is enabled to monitor and compensate for the body movement of the scanned object in real time. By capturing small translational and rotational deviations of the scanned object during the acquisition process, and calibrating the scanning coordinate system in real time based on the initial orientation of the ROI in the low-resolution reference guide image, the imaging orientation offset caused by the body movement of the scanned object is offset. This ensures that the spatial orientation of the ROI in the acquired initial positioning image is accurately consistent with that in the low-resolution reference guide image, avoiding orientation misalignment caused by body movement interference. This ensures the orientation accuracy of the initial positioning parameters extracted based on the initial positioning image and provides a reliable orientation basis for parameter correction and precise positioning in subsequent scanning stages.

[0034] Step S2: Acquire the current guiding image and register it with the low-resolution reference guiding image to calculate the current positioning parameters of the region of interest at the current time.

[0035] In one embodiment, during a preset preparation interval before the start of each main sequence scan, the same imaging sequence parameters as the low-resolution reference guide image are invoked to acquire the guide image at the current moment. The preset preparation interval is a reserved preparation period before the formal start of each main sequence scan. The duration of this period can be flexibly set according to scanning requirements. Its core purpose is to reserve time for subsequent image registration and motion parameter calculation, avoiding conflicts with the imaging process of the main sequence scan and ensuring the orderly progress of the entire scanning process. The invoked imaging sequence parameters are completely identical to those used when acquiring the low-resolution reference guide image, including key parameters such as scan sequence type, gradient intensity, signal acquisition duration, and field of view size. This ensures that the guide image at the current moment and the low-resolution reference guide image are low-resolution images of the same modality and parameters, effectively eliminating problems such as inconsistent image grayscale features and spatial resolution caused by differences in sequence parameters, providing a foundation for accurate registration of the two images subsequently. During the preset preparation period, the magnetic resonance scanning system rapidly acquires the current guiding image according to the called sequence parameters. During the acquisition process, the body movement of the scanned object is initially captured. The acquired current guiding image needs to clearly show the overall orientation of the scanned object and reflect the approximate spatial position of the region of interest at the current moment. This image serves as a reference image for subsequent registration with the low-resolution reference guiding image and for calculating the current positioning parameters. This provides an intuitive image basis for real-time capture of the body movement changes of the scanned object and correction of the positioning deviation of the region of interest.

[0036] It should be noted that the "guided image at the current moment" of this invention is a specially designed real-time acquired image. This real-time acquisition feature is a necessary condition for this invention to achieve accurate dynamic positioning of the region of interest in the body movement state of the scanned object, which is fundamentally different from the non-real-time T2WI routinely used in clinical practice. Regarding the guided image acquisition stage, this invention abandons the conventional T2WI approach of acquiring high-resolution, high signal-to-noise ratio diagnostic imaging data, and instead employs an optimized rapid imaging sequence. Furthermore, the acquisition action is strictly bound to a preset preparation interval before the start of each round of main sequence scanning. By omitting time-consuming steps, the overall acquisition cycle of a single frame of guide image is compressed. The acquisition process is completely synchronized with the body movement state of the scanned object at the current moment. After acquisition, image registration can be performed immediately without additional waiting, achieving real-time capture and instant acquisition of the spatial orientation of the region of interest of the scanned object at the current moment. The acquired guiding images can accurately reflect the actual orientation state of the scanned object after body movement, providing a real-time and effective image reference for subsequent motion parameter calculation and current positioning parameter derivation. In contrast, the T2WI acquisition design used in clinical applications is aimed at image quality. It requires multiple signal accumulation and complete phase encoding to improve resolution and signal-to-noise ratio. The acquisition cycle of a single image / group of images is usually between ten seconds and several minutes, with obvious time window delay. Moreover, there is no strict requirement for real-time binding of the acquisition sequence. It can only reflect the average orientation state of the scanned object within a certain time period and cannot accurately capture the real-time orientation after body movement at a specific moment. It belongs to a typical non-real-time acquisition mode.

[0037] In one embodiment, registering the current guiding image with the low-resolution reference guiding image to obtain motion parameters includes: firstly, simultaneously performing grayscale normalization processing on the current guiding image and the low-resolution reference guiding image to eliminate differences in image grayscale values ​​caused by signal intensity fluctuations of the magnetic resonance equipment and slight physiological activities of the scanned object during the two image acquisitions, unifying the grayscale features of the two images, and avoiding interference from grayscale deviations on the spatial position comparison accuracy of subsequent registration, thus laying the foundation for accurate registration. Next, performing image spatial position comparison analysis on the two images after grayscale normalization processing, using the feature points of the region of interest in the low-resolution reference guiding image as a fixed reference, accurately comparing the spatial position changes of the corresponding feature points in the current guiding image, and capturing the overall body movement of the scanned object by calculating the difference in spatial coordinates; finally, based on the calculation results of the above spatial position comparison, extracting six-degree-of-freedom motion parameters including translation parameters along the X / Y / Z axes and rotation parameters around the X / Y / Z axes. The six-degree-of-freedom motion parameters comprehensively and quantitatively characterize the overall body motion changes of the scanned object from the acquisition of the low-resolution reference guided image to the acquisition of the guided image at the current moment. They accurately reflect the spatial displacement and attitude changes of the region of interest caused by the body motion of the scanned object, providing a quantitative basis for the body motion of the region of interest at the current moment for subsequent calculation of the current positioning parameters of the region of interest.

[0038] In one embodiment, the spatial transformation calculation of the motion parameters combined with the initial positioning parameters to obtain the current positioning parameters of the region of interest at the current moment includes: First, clarifying the correspondence between the motion parameters and the initial positioning parameters. The three translation parameters in the motion parameters are used to quantify the overall spatial displacement of the scanned object, while the spatial coordinate parameters in the initial positioning parameters are used to characterize the initial spatial position of the region of interest, such as the three-dimensional spatial coordinates of the center point of the region of interest and the coordinate range of the scan field boundary. The two are then superimposed, i.e., the three translation parameters are respectively superimposed onto the X, Y, and Z axes of the initial spatial coordinate parameters. The positional offset of the region of interest caused by the motion of the scanned object is offset by accumulating the coordinate differences, ultimately obtaining the position parameters of the region of interest at the current moment. These position parameters accurately reflect the actual spatial coordinates of the region of interest in the scan coordinate system at the current moment, ensuring that subsequent scans can accurately locate the current position of the region of interest.

[0039] Similarly, the three rotation parameters in the motion parameters and the azimuth angle parameters in the initial positioning parameters are used to perform angle correction calculations. The azimuth angle parameters in the initial positioning parameters are used to characterize the initial spatial orientation of the region of interest, such as the angle between the scanning plane and the main distribution direction of the region of interest, the phase encoding direction angle, etc. The three rotation parameters correspond to the rotation angles around the X, Y, and Z axes, respectively. By correcting the difference between the rotation angle and the initial azimuth angle, the spatial orientation of the region of interest is adapted to the change in the posture of the scanned object. Finally, the spatial orientation parameters of the region of interest at the current moment are obtained, ensuring that the scanning perspective can fit the spatial distribution state of the current region of interest.

[0040] Finally, the calculated location parameters and spatial orientation parameters of the region of interest at the current moment are integrated. During the integration process, the consistency of the two types of parameters is checked to ensure that the location parameters and spatial orientation parameters correspond and match without logical deviation. Finally, the current positioning parameters of the region of interest at the current moment are obtained. These current positioning parameters fully contain the real-time spatial location and spatial orientation information of the region of interest, providing accurate parameter support for the subsequent magnetic resonance scanning control system to dynamically update the scanning coordinate system and execute the main sequence scanning, ensuring that each round of main sequence scanning can be carried out accurately around the region of interest.

[0041] Step S3: Based on the current positioning parameters, control the magnetic resonance scanning control system to perform the main sequence scan and obtain the current main sequence image.

[0042] In one embodiment, based on the real-time input of the current positioning parameters, the present invention controls the magnetic resonance scanning control system to synchronously update the current scanning orientation of the region of interest at the current moment. Specifically, the magnetic resonance scanning control system receives the current positioning parameters calculated in the aforementioned steps in real time. These current positioning parameters include the position parameters and spatial orientation parameters of the region of interest at the current moment. Based on these two types of parameters, the system synchronously adjusts the spatial reference of the scanning coordinate system, accurately updates the scanning orientation of the region of interest at the current moment, and ensures that the updated scanning orientation completely matches the real-time spatial position and orientation of the region of interest, thus offsetting the orientation deviation caused by the movement of the scanned object.

[0043] After completing the synchronous update of the current scanning orientation, the magnetic resonance imaging control system starts the main sequence scan according to the updated current scanning orientation. The main sequence scan uses a scanning sequence and parameters adapted to high-resolution imaging of the region of interest, focusing on the current region of interest for precise scanning. During the scanning process, it continuously relies on the calibration results of the current scanning orientation to avoid interference from the instantaneous body movement of the scanned object. Finally, the current main sequence image is obtained through this round of main sequence scans. The current main sequence image can clearly and completely present the spatial distribution of the region of interest at the current moment, without obvious body movement artifacts, providing a reliable imaging basis for subsequent medical analysis and diagnosis.

[0044] In one embodiment, the magnetic resonance scanning control system integrates software and hardware systems and functional devices, consisting of an MRI scanning control unit, a sequence acquisition unit, an image reconstruction unit, an image registration unit, and a scanning information feedback unit. Each unit cooperates and communicates with each other according to a preset logic to jointly complete the entire process of magnetic resonance scanning, including parameter adjustment, image acquisition, data processing, orientation correction, and information feedback.

[0045] In one embodiment, motion correction technology is employed during the acquisition of the current master sequence image to ensure that the orientation of the region of interest (ROI) in the current master sequence image is consistent with that in the current guide image. Specifically, motion correction technology is simultaneously activated during the initiation of the master sequence scan and the acquisition of the current master sequence image. This motion correction technology works in conjunction with the correction logic in the initial positioning image acquisition and current guide image registration processes. Using the orientation of the ROI in the current guide image as an immediate reference, and combined with the real-time input current positioning parameters, it monitors in real-time any transient minor body movements, including slight translations and rotations, that may occur during the master sequence scan. When body movement interference is detected, the motion correction technology quickly calculates the ROI orientation offset caused by the body movement and immediately feeds it back to the magnetic resonance imaging (MRI) scan control system. The system dynamically fine-tunes the real-time scanning orientation of the master sequence scan based on this offset, ensuring that the scanning angle always matches the spatial orientation of the ROI in the current guide image, thus preventing orientation misalignment between the current master sequence image and the current guide image due to sudden body movements during the master sequence scan. Through the continuous action of this motion correction technology, it is possible to effectively ensure that the spatial orientation of the region of interest in the current main sequence image is consistent with the orientation of the region of interest in the current guiding image, further improving the imaging accuracy of the current main sequence image, reducing the influence of motion artifacts, and ensuring the continuity and positioning accuracy of the entire main sequence scanning process.

[0046] To better describe the image-guided magnetic resonance imaging repetitive scanning consistent localization method, the following specific embodiments are provided.

[0047] Example 1: Consistent localization method for repeated scanning of perivascular lacunar infarcts and perforating arteries in the whole brain. For example... Figure 2 The following diagram further illustrates the implementation steps.

[0048] Step 1: Acquire low-resolution reference guidance image and initial positioning image.

[0049] A rapid fat imaging sequence was used to quickly acquire baseline fat-guided image data, with a single acquisition time of approximately 3.33 seconds. This data was configured as a low-resolution baseline fat-guided image, serving as the spatial orientation reference for all subsequent scanning stages. Subsequently, based on this low-resolution baseline fat-guided image, a 3D T2-weighted imaging sequence was used to acquire initial localization images to clearly display the distribution of perivascular cavities throughout the brain. After preprocessing the initial localization images, the nnUNet deep learning model was used to segment the perivascular cavities and generate masks. The orientation of the scanning layers was optimized based on the masks to ensure that they intersected perpendicularly with the most perivascular cavities. Finally, relevant parameters were extracted and integrated to form the initial localization parameters for the region of interest.

[0050] Step 2: Obtain the guidance image at the current moment.

[0051] During the preset preparation interval before each round of main sequence (time-flying sequence) acquisition, the same fast imaging sequence parameters as the low-resolution baseline fat-guided image are called to acquire the fat-guided image at the current moment in real time.

[0052] Step 3: Guide image registration.

[0053] The reconstructed fat-guided image at the current moment is registered in three dimensions with the low-resolution reference fat-guided image in step 1 to extract six degrees of freedom motion parameters (X / Y / Z axis translation and rotation parameters).

[0054] Step 4: Calculate the current positioning parameters.

[0055] The six-degree-of-freedom motion parameters are spatially transformed and calculated with the initial positioning parameters obtained in step 1. The translation parameters are superimposed to obtain the current position parameters, and the rotation parameters are corrected to obtain the current spatial orientation parameters. After verification and integration, the current positioning parameters are obtained.

[0056] Step 5: Obtain the current main sequence image.

[0057] The current positioning parameters are input into the MRI scan control system in real time. The system synchronously updates the main sequence scan coordinate system and dynamically adjusts the scan orientation to compensate for orientation deviations caused by head movement. During the main sequence scan, motion correction technology is activated to monitor and fine-tune the scan orientation in real time, ensuring that the orientation of the region of interest in the current main sequence image is consistent with that in the current guiding image. Time-flying sequence scanning is then initiated to obtain clear perforator artery imaging (i.e., the current main sequence image).

[0058] This embodiment uses a fat map as a navigation guide map. By acquiring the current guidance image in real time, registering it with the reference guidance image to calculate motion parameters, and dynamically updating the scanning orientation, it achieves efficient positioning without increasing the scanning time overhead. In the same scanning experiment, through real-time guidance before the main sequence scanning, registration correction, and motion correction during the scanning process, it ensures that the imaging area of ​​each round of main sequence scanning always matches the preset target position. In the longitudinal scanning experiment, even if the subject's head rotates at a large angle relative to the first scan, it can ensure that the scanning area of ​​each scan remains highly consistent, ensuring the comparability of longitudinal experimental data. It effectively solves the technical pain points of inaccurate positioning, low efficiency, and poor longitudinal scanning consistency of traditional magnetic resonance repeated scanning, and achieves accurate, efficient, and consistent positioning for repeated scanning.

[0059] The foregoing has provided a detailed explanation of the implementation process and principle of an image-guided magnetic resonance imaging repetitive scan coherence localization method provided in the embodiments of this application. The following will further describe the image-guided magnetic resonance imaging repetitive scan coherence localization system and terminal of the present invention in conjunction with embodiments.

[0060] Similar to the principles of the above embodiments, the present invention provides an image-guided magnetic resonance imaging repetitive scanning coherent localization system.

[0061] The following specific embodiments are provided in conjunction with the accompanying drawings:

[0062] like Figure 3 This invention presents a schematic diagram of an image-guided magnetic resonance imaging repetitive scanning coherent localization system according to an embodiment of the present invention.

[0063] The system 300 includes:

[0064] The positioning scanning module 301 is used to acquire a low-resolution reference guide image and an initial positioning image for locating the region of interest.

[0065] The registration calculation module 302 is used to acquire the guidance image at the current moment, register it with the low-resolution reference guidance image, and calculate the current positioning parameters of the region of interest at the current moment.

[0066] The real-time main sequence scanning module 303 is used to control the magnetic resonance scanning control system to perform main sequence scanning based on the current positioning parameters, and obtain the current main sequence image.

[0067] Since the implementation principle of the image-guided magnetic resonance imaging repetitive scanning consistent localization system has been described in the foregoing embodiments, it will not be repeated here. It should also be understood that the module division in the embodiments of this application is illustrative and merely a logical functional division; other division methods may be used in actual implementation. Furthermore, the functional modules in the various embodiments of this application can be integrated into a single processor, exist as separate physical entities, or have two or more modules integrated into one module. The integrated modules described above can be implemented in hardware or as software functional modules.

[0068] The image-guided magnetic resonance imaging repetitive scan coherent localization method provided in this invention can be implemented on the terminal side or the server side. For the hardware structure of the electronic terminal, please refer to [link to relevant documentation]. Figure 4 This is a schematic diagram of an optional hardware structure of an electronic terminal 4000 provided in an embodiment of the present invention. The terminal 4000 can be a mobile phone, computer device, tablet device, personal digital processing device, factory back-end processing device, etc. The terminal 4000 includes: at least one processor 4001, a memory 4002, at least one network interface 40010, and a user interface 4009. The various components in the device are coupled together through a bus system 4005. It is understood that the bus system 4005 is used to realize the connection and communication between these components. In addition to a data bus, the bus system 4005 also includes a power bus, a control bus, and a status signal bus. However, for clarity, in... Figure 4 The general will label all buses as bus systems.

[0069] The user interface 4009 may include a monitor, keyboard, mouse, trackball, clicker, button, touchpad, or touch screen.

[0070] It is understood that memory 4002 can be volatile memory or non-volatile memory, or both. Non-volatile memory can be read-only memory (ROM) or programmable read-only memory (PROM), which serves as an external cache. By way of example, but not limitation, many forms of RAM are available, such as static random access memory (SRAM) and synchronous static random access memory (SSRAM). The memories described in the embodiments of this invention are intended to include, but are not limited to, these and any other suitable categories of memory.

[0071] In this embodiment of the invention, the memory 4002 is used to store various types of data to support the operation of the terminal 4000. Examples of this data include: any executable program for operation on the terminal 4000, such as the operating system 40021 and application programs 40022; the operating system 40021 contains various system programs, such as the framework layer, core library layer, driver layer, etc., for implementing various basic services and handling hardware-based tasks. The application program 40022 may contain various applications, such as a media player, browser, etc., for implementing various application services. The implementation of the image-guided magnetic resonance imaging repetitive scanning consistent localization method provided in this embodiment of the invention can be included in the application program 40022.

[0072] The methods disclosed in the above embodiments of the present invention can be applied to, or implemented by, processor 4001. Processor 4001 may be an integrated circuit chip with signal processing capabilities. During implementation, each step of the above methods can be completed by integrated logic circuits in the hardware of processor 4001 or by instructions in software form. Processor 4001 may be a general-purpose processor, a digital signal processor (DSP), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. Processor 4001 can implement or execute the methods, steps, and logic block diagrams disclosed in the embodiments of the present invention. General-purpose processor 4001 may be a microprocessor or any conventional processor, etc. The steps of the accessory optimization method provided in the embodiments of the present invention can be directly manifested as execution by a hardware decoding processor, or execution by a combination of hardware and software modules in the decoding processor. The software modules may be located in a storage medium, which is located in a memory. The processor reads information from the memory and, in conjunction with its hardware, completes the steps of the aforementioned methods.

[0073] In an exemplary embodiment, the terminal 4000 may be used by one or more application-specific integrated circuits (ASICs), DSPs, programmable logic devices (PLDs), or complex programmable logic devices (CPLDs) to execute the aforementioned method.

[0074] Those skilled in the art will understand that all or part of the steps of the above-described method embodiments can be implemented using computer program-related hardware. The aforementioned computer program can be stored in a computer-readable storage medium. When executed, the program performs the steps of the above-described method embodiments; and the aforementioned storage medium includes various media capable of storing program code, such as ROM, RAM, magnetic disks, or optical disks.

[0075] In the embodiments provided in this application, the computer-readable and writable storage medium may include read-only memory, random access memory, EEPROM, CD-ROM or other optical disc storage devices, disk storage devices or other magnetic storage devices, flash memory, USB flash drive, portable hard drive, or any other medium capable of storing desired program code in the form of instructions or data structures and accessible by a computer. Additionally, any connection may be appropriately referred to as a computer-readable medium. For example, if instructions are transmitted from a website, server, or other remote source using coaxial cable, fiber optic cable, twisted pair, digital subscriber line (DSL), or wireless technologies such as infrared, radio, and microwave, then the coaxial cable, fiber optic cable, twisted pair, DSL, or wireless technologies such as infrared, radio, and microwave are included in the definition of medium. However, it should be understood that computer-readable and writable storage media and data storage media do not include connections, carrier waves, signals, or other transient media, but are intended for non-transient, tangible storage media. The disks and optical discs used in the application include compact optical discs (CDs), laser optical discs, optical discs, digital multifunction optical discs (DVDs), floppy disks, and Blu-ray discs, where disks typically copy data magnetically, while optical discs use lasers to copy data optically.

[0076] In summary, this invention provides an image-guided magnetic resonance imaging (MRI) repetitive scanning consistent localization method, system, and terminal, offering the following advantages: This invention is applied to MRI scanning localization, acquiring a low-resolution reference guiding image and an initial localization image for locating the region of interest (ROI); acquiring the current guiding image and registering it with the low-resolution reference guiding image to calculate the current localization parameters of the ROI; based on the real-time input of the current localization parameters, the MRI scanning control system performs the main sequence scan to obtain the current main sequence image. This invention overcomes the technical problems of weakened subtle signals due to post-registration, localization deviations caused by body movement, and the difficulty in balancing imaging efficiency and effectiveness in the field of repetitive scanning localization in current MRI technology; this invention provides a technical solution that achieves accurate and efficient consistent localization without additional hardware support, meeting the high precision and high stability requirements of MRI in scenarios such as early disease diagnosis and longitudinal scientific research tracking.

[0077] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. A method for consistent localization of repeated scans in magnetic resonance imaging based on image guidance, characterized in that, The method includes: Acquire a low-resolution reference guide image and an initial localization image for locating the region of interest; Acquire the current guidance image and register it with the low-resolution reference guidance image to calculate the current positioning parameters of the region of interest at the current moment; Based on the current positioning parameters, the magnetic resonance scanning control system is controlled to perform the main sequence scan and obtain the current main sequence image.

2. The image-guided magnetic resonance imaging repetitive scan coherent localization method according to claim 1, characterized in that, The acquisition of the low-resolution reference guiding image and the initial localization image for locating the region of interest includes: Acquire low-resolution reference guide images; Based on the low-resolution reference guiding image, an initial positioning image with the same orientation as the low-resolution reference guiding image is obtained, and the initial positioning parameters of the corresponding region of interest are obtained.

3. The image-guided magnetic resonance imaging repetitive scan coherent localization method according to claim 1, characterized in that, The process of acquiring the current guiding image and registering it with the low-resolution reference guiding image, and calculating the current positioning parameters of the region of interest at the current moment, includes: The same imaging sequence parameters as the low-resolution reference guide image are used to acquire the guide image at the current moment; The current guiding image is registered with the low-resolution reference guiding image to obtain motion parameters; By combining the motion parameters with the initial positioning parameters, spatial transformation calculations are performed to obtain the current positioning parameters of the region of interest at the current moment.

4. The image-guided magnetic resonance imaging repetitive scan consistent localization method according to claim 3, characterized in that, The step of registering the current guidance image with the low-resolution reference guidance image to obtain motion parameters includes: The current guidance image and the low-resolution reference guidance image are subjected to grayscale normalization, and the six-degree-of-freedom motion parameters, including three translation parameters and three rotation parameters, are obtained through image spatial position comparison and analysis.

5. The image-guided magnetic resonance imaging repetitive scan coherent localization method according to claim 4, characterized in that, The step of combining the motion parameters with the initial positioning parameters to perform spatial transformation calculations to obtain the current positioning parameters of the region of interest at the current moment includes: The three translation parameters in the motion parameters are superimposed with the spatial coordinate parameters in the initial positioning parameters to obtain the position parameters of the region of interest at the current moment; The three rotation parameters in the motion parameters are adjusted by angle correction with the azimuth angle parameters in the initial positioning parameters to obtain the spatial orientation parameters of the region of interest at the current moment. By integrating the location parameters and the spatial orientation parameters, the current positioning parameters of the region of interest at the current moment are obtained.

6. The image-guided magnetic resonance imaging repetitive scan coherent localization method according to claim 1, characterized in that, The step of controlling the magnetic resonance scanning control system to perform the main sequence scan based on the current positioning parameters and obtaining the current main sequence image includes: Based on the current positioning parameters, the magnetic resonance scanning control system is controlled to synchronously update the current scanning orientation of the region of interest at the current moment in real time, and the magnetic resonance scanning control system is controlled to perform the main sequence scanning according to the current scanning orientation to obtain the current main sequence image.

7. The image-guided magnetic resonance imaging repetitive scan coherent localization method according to claim 2 or 6, characterized in that, During the acquisition of the initial positioning image, motion correction techniques can be used to adjust the region of interest in the initial positioning image and the low-resolution reference guide image to be aligned in orientation. During the acquisition of the current main sequence image, motion correction techniques can be used to adjust the region of interest in the current main sequence image and the guiding image at the current moment to be in the same orientation.

8. An image-guided magnetic resonance imaging repetitive scan coherent localization system, characterized in that, The system includes: The positioning scanning module is used to acquire a low-resolution reference guide image and an initial positioning image for locating the region of interest. The registration calculation module is used to acquire the guidance image at the current moment, register it with the low-resolution reference guidance image, and calculate the current positioning parameters of the region of interest at the current moment. The real-time main sequence scanning module is used to control the magnetic resonance scanning control system to perform main sequence scanning based on the current positioning parameters, and obtain the current main sequence image.

9. A computer program product, characterized in that, The computer program product includes computer program code that, when run on a computer, causes the computer to implement the method as described in any one of claims 1 to 7.

10. An electronic terminal, comprising a memory, a processor, and a computer program stored in the memory, characterized in that, The processor executes the computer program to implement the method according to any one of claims 1 to 7.

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