Sensitive skin barrier repairing composition as well as preparation method and application thereof

Abstract

The invention provides a sensitive skin barrier repairing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. Comprising the following components in percentage by weight: 1.5-5% of a polysaccharide component, 0.0001-0.01% of a peptide component, 0.1-1% of a carotenoid component, 3-10% of an unsaturated fatty acid component, 1-3% of an algae extract component and the balance of a matrix component, totaling 100%. The sensitive skin barrier repairing composition prepared by the invention systematically repairs a physical barrier, a chemical barrier, an immune barrier and a micro-ecological barrier of skin by simultaneously acting on a plurality of biological targets related to sensitive skin, so that uncomfortable symptoms such as skin redness, pruritus, scorching hot and the like are efficiently relieved.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a sensitive skin barrier repair composition, its preparation method, and its application. Background Technology

[0002] Sensitive skin is a highly intolerant skin condition, easily irritated by external physical, chemical, and psychological factors, producing subjective symptoms such as burning, stinging, itching, tightness, and erythema, often accompanied by impaired skin barrier function. Traditional treatments often target single symptoms or the skin barrier, with limited and unsustainable effects. For example, simply using occlusive oils to repair the physical barrier neglects inflammation control; or simply using anti-inflammatory ingredients fails to fundamentally improve the barrier structure, leading to recurring problems.

[0003] The skin barrier is a complex, multidimensional system, including: Physical barrier: mainly composed of the "brick wall structure" of the stratum corneum, preventing moisture loss and the invasion of external irritants.

[0004] Chemical barrier: including natural moisturizing factors, sebum film, interstitial lipids, etc., maintains the skin's slightly acidic environment and hydration.

[0005] Immune barrier: Composed of immune cells in the epidermis and dermis and the cytokines they secrete, it is the skin's defense and response system.

[0006] Microbial barrier: Composed of symbiotic microbial communities on the skin surface, it maintains a healthy skin microenvironment and inhibits harmful bacteria.

[0007] Currently, few products can systematically and synergistically repair the barriers across the four dimensions mentioned above to achieve a fundamental relief from the redness and itching of sensitive skin. Sensitive skin is characterized by a lowered threshold for skin response to external stimuli. Its mechanisms are complex, involving multiple factors such as barrier structure damage, hyperresponsiveness of nerve endings, immune inflammatory imbalance, and skin microecological disturbance. Traditional soothing products often employ single ingredients or pathways of action, such as using only occlusive moisturizers, single anti-inflammatory ingredients, or nerve soothing agents. These methods are insufficient for achieving fundamental and lasting repair and cannot comprehensively address the aforementioned multidimensional pathophysiological changes. Summary of the Invention

[0008] The purpose of this invention is to provide a sensitive skin barrier repair composition, its preparation method, and its application, offering a sensitive skin repair composition based on multi-target synergistic effects. This composition, through carefully selected polysaccharides, peptides, carotenoids, unsaturated fatty acids, and specific algal extracts, forms a synergistic formula that simultaneously targets key aspects of sensitive skin, including **barrier structure damage, neurogenic inflammation, immune overreaction, and microecological imbalance**, systematically repairing the skin's four-layer barrier, thereby effectively and safely relieving symptoms such as redness and itching.

[0009] The technical solution of this invention is implemented as follows: The present invention provides a sensitive skin barrier repair composition comprising the following components by weight percentage: 1.5-5% polysaccharide component, 0.0001-0.01% peptide component, 0.1-1% carotenoid component, 3-10% unsaturated fatty acid component, 1-3% algae extract component, and up to 100% matrix component.

[0010] As a further improvement of the present invention, the polysaccharide component is selected from at least one of glycerol glucoside, trehalose, fucoidan, and mannose.

[0011] As a further improvement of the present invention, the peptide component is selected from at least one of Spirulina polypeptide, Euglena polypeptide, Haematococcus pluvialis active peptide, Dunaliella salina active peptide, and diatom active peptide complex.

[0012] As a further improvement of the present invention, the carotenoid component is selected from at least one of astaxanthin, fucoxanthin, lycopene, β-carotene, and lutein.

[0013] As a further improvement of the present invention, the unsaturated fatty acid component is selected from at least one of jojoba oil, flaxseed oil, olive oil, sunflower seed oil, and sea buckthorn fruit oil.

[0014] As a further improvement of the present invention, the algae extract component is selected from at least one of Spirulina extract, Phlox subulata extract, Chlorella extract, and Haematococcus pluvialis extract.

[0015] As a further improvement of the present invention, the matrix components include deionized water, butanediol, p-hydroxyacetophenone, 1,2-hexanediol, emulsifier, and thickener, in a mass ratio of 100:2-4:0.01-0.015:1-3:2-4:3-5; the emulsifier is carbomer; and the thickener is carboxymethyl cellulose.

[0016] This invention further protects a method for preparing the above-mentioned sensitive skin barrier repair composition, comprising the following steps: (1) Heat and mix the unsaturated fatty acid components until homogeneous to obtain the oil phase; (2) The polysaccharide component, peptide component, carotenoid component and algae extract component are mixed and added to the matrix component, and stirred and mixed evenly to obtain an aqueous phase; (3) The oil phase is added to the aqueous phase under stirring conditions and homogenized and emulsified to obtain a sensitive skin barrier repair composition.

[0017] As a further improvement of the present invention, the heating temperature is 50-70℃, the homogenization rotation speed is 10000-12000r / min, and the time is 15-25min.

[0018] This invention further protects the use of the above-mentioned sensitive skin barrier repair composition in cosmetics for improving the condition of sensitive skin.

[0019] I. Technical solutions for physical barrier repair Directly replenish the "mortar": Unsaturated fatty acids (such as Omega 3, 6, 9) are added directly to the intercellular lipids of the stratum corneum as exogenous lipids to repair the "brick wall structure".

[0020] Promoting the health of keratinocytes: Certain peptides can promote the proliferation and differentiation of keratinocytes and the expression of tight junction proteins (such as Claudin1) through signal transduction, thereby strengthening the keratinocytes themselves.

[0021] Algae-assisted: Chlorella and other algae are rich in amino acids and polysaccharides, providing nutrients to cells and supporting the construction of physical barriers.

[0022] II. Technical Solutions for Chemical Barrier Repair Activation of aquaporin 3 (AQP3): Glyceryl glucoside is the core of this approach. It can specifically activate AQP3 on skin keratinocytes, significantly enhancing the skin's own moisturizing ability and water transport capacity. This is a key target for rebuilding a healthy chemical barrier.

[0023] Supplementing natural moisturizing factor (NMF) precursors: The amino acids and minerals abundant in algae extracts can serve as raw materials for synthesizing NMF.

[0024] Maintaining skin pH: The overall formulation of the composition is designed to be slightly acidic, which helps maintain the skin's normal chemical environment. III. Technical Solutions for Immune Barrier Repair Inhibition of the core inflammatory pathway (NFκB, MAPK): Carotenoids such as astaxanthin and fucoxanthin can effectively penetrate cells and inhibit the activation of transcription factors such as NFκB, thereby inhibiting the production of various pro-inflammatory cytokines (such as TNFα, IL6, IL1β) downstream. This is the core target for controlling immune overreaction and reducing erythema.

[0025] Regulating immune cell activity: Peptides and active substances in extracts of spirulina and Haematococcus pluvialis can regulate the activity of immune cells such as Langerhans cells and mast cells, thereby stabilizing the immune status.

[0026] Antioxidant protection: Effectively scavenges free radicals and reduces the activation of immune cells by oxidative stress.

[0027] IV. Technical Solutions for Micro-ecological Barrier Restoration Provides prebiotics: Glyceryl glucoside and algal polysaccharides can serve as a nutrient source (prebiotics) for beneficial bacteria on the skin, promoting their growth.

[0028] Inhibits harmful bacteria: Some algae extracts (such as Phlox subulata) contain antimicrobial peptides or create a microenvironment unfavorable to the growth of harmful bacteria (such as Staphylococcus aureus).

[0029] Indirect regulation: By repairing the above-mentioned triple barriers (especially the chemical and immune barriers), a healthy skin surface environment (appropriate humidity, pH, and lipid composition) is created for the symbiotic microbiota, indirectly promoting the balance of the microecology.

[0030] The present invention has the following beneficial effects: 1. Multi-target precision intervention: For the first time, it systematically integrates active ingredients targeting multiple key targets of sensitive skin, such as AQP3 activation (glyceroglucoside), NF-κB inhibition (astaxanthin / fucoxanthin), direct lipid supplementation (unsaturated fatty acids), cell signal regulation (peptides), and microecological nutrition (algal polysaccharides), achieving comprehensive intervention from upstream mechanisms to downstream symptoms.

[0031] 2. "Repair-Soothe" in Sync: The carotenoids and peptides in the formula can quickly reduce inflammation and soothe nerves, providing immediate comfort; while glyceryl glucosides, unsaturated fatty acids and algae nutrients fundamentally promote the long-term reconstruction of the skin barrier, achieving a balance between immediate effects and long-term efficacy.

[0032] 3. Strong ingredient synergy: The selected ingredients are not only effective on their own pathways, but also promote each other. For example, glyceryl glucoside improves the skin's hydration environment, which facilitates the penetration and effectiveness of other active ingredients; astaxanthin reduces inflammation, clearing obstacles for barrier repair.

[0033] 4. Natural and highly effective: The core active ingredients are all derived from nature (algae, plants), ensuring high safety and making them suitable for long-term use on sensitive skin. At the same time, the scientific formulation and targeted design guarantee significant efficacy.

[0034] 5. Provides a clear technical paradigm: This solution is not only a product formula, but also clarifies an effective technical path for developing sensitive skin repair products through "multi-target active ingredient combination → synergistic repair of four barriers → relief of sensitivity symptoms".

[0035] Glyceryl glucoside enhances moisturizing power while increasing the penetration and utilization of other active ingredients (such as astaxanthin and peptides) in the skin; the powerful anti-inflammatory properties of astaxanthin and other ingredients create a stable, low-inflammatory environment for barrier repair; and the repaired physical and chemical barriers provide a foundation for microecological balance. All components work in tandem to form a positive repair cycle. Detailed Implementation

[0036] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0037] Example 1: A composition for repairing the skin barrier of sensitive skin Formula composition (by weight percentage): Glyceryl glucoside 2.0%; Palmitoyl tripeptide 5 0.01%; Astaxanthin (from Haematococcus pluvialis oil) 0.1%; Fucoxanthin (from *Phaeodactylum tricornutum* extract) 0.5%; Flaxseed oil (rich in unsaturated fatty acids) 3.0%; Spirulina extract 2.0%; Chlorella extract 1.0%; Matrix up to 100%; The matrix components include deionized water, butanediol, p-hydroxyacetophenone, 1,2-hexanediol, carbomer, and carboxymethyl cellulose in a mass ratio of 100:2:0.01:1:2:3.

[0038] The preparation process includes the following steps: Flaxseed oil was heated to 50°C to obtain the oil phase; polyglycerol glucoside, palmitoyl tripeptide 5, astaxanthin, fucoxanthin, spirulina extract, and chlorella extract were mixed and added to the matrix components, stirred and mixed evenly to obtain the aqueous phase; (3) the oil phase was added to the aqueous phase under stirring conditions, and homogenized and emulsified at 10000r / min for 15min to obtain the sensitive skin barrier repair composition.

[0039] Example 2: A sensitive skin barrier repair composition Formula composition (by weight percentage): Glyceryl glucoside 1.5%; Acetyl tetrapeptide 15 0.001%; Haematococcus pluvialis extract (rich in astaxanthin) 1.0%; Lycopene 0.5%; Trehalose (simulating a chemical barrier) 3.0%; Jojoba oil (simulates sebum, rich in unsaturated fatty acids) 5.0%; 1.5% of *Phaeodactylum tricornutum* extract; Ceramide NP (assistive physical barrier) 0.5%; Matrix up to 100%; The matrix components include deionized water, butanediol, p-hydroxyacetophenone, 1,2-hexanediol, carbomer, and carboxymethyl cellulose in a mass ratio of 100:4:0.015:3:4:5.

[0040] The preparation process includes the following steps: (1) Heat jojoba oil to 70°C to obtain the oil phase; (2) Glyceryl glucoside, trehalose, acetyl tetrapeptide 15, ceramide NP, Haematococcus pluvialis extract and Phytophthora triangularis extract were mixed and added to the matrix components, stirred and mixed evenly to obtain an aqueous phase; (3) Under stirring conditions, the oil phase was added to the aqueous phase and homogenized and emulsified at 12000 r / min for 25 min to obtain the sensitive skin barrier repair composition.

[0041] Example 3: A sensitive skin barrier repair composition Formula composition (by weight percentage): Glyceryl glucoside 1.5%; Acetyl hexapeptide 8 0.0001%; Acetyl heptapeptide 1 0.0001%; β-carotene 1%; Olive oil 10%; Matrix up to 100%; The matrix components include deionized water, butanediol, p-hydroxyacetophenone, 1,2-hexanediol, carbomer, and carboxymethyl cellulose in a mass ratio of 100:3:0.012:2:3:4.

[0042] The preparation process includes the following steps: (1) Heat jojoba oil to 60°C to obtain the oil phase; (2) Glyceryl glucoside, trehalose, acetyl tetrapeptide 15, ceramide NP, Haematococcus pluvialis extract and Phytophthora triangularis extract were mixed and added to the matrix components, stirred and mixed evenly to obtain an aqueous phase; (3) Under stirring conditions, the oil phase was added to the aqueous phase and homogenized and emulsified at 11000 r / min for 20 min to obtain the sensitive skin barrier repair composition.

[0043] Test Example 1: Human Patch Test Test substance: Sensitive skin barrier repair compositions prepared in Examples 1-3 Negative control: Deionized water Participants: A total of 80 participants, 0 males and 80 females, aged 21-54 years, were divided into 4 groups: negative control group, Example 1-3 group, with 20 participants in each group, meeting the criteria for voluntary inclusion of participants.

[0044] Patch Method: Using a qualified patch applicator and a closed patch test method, approximately 0.020 mL-0.025 mL of the test substance and negative control were dropped into the patch applicator. The applicator was then applied to the back of the subject using special adhesive tape. The test substance was removed after 24 hours. Skin reactions were observed at 0.5, 24, and 48 hours after removal, and the results were recorded according to the skin reaction grading standards in the "Cosmetic Hygiene Standard" (2007 edition). The test results are shown in Table 1. Table 1 Results of human skin patch test

[0045] Human skin patch test results showed that no adverse skin reactions occurred in any of the cases; indicating that the cosmetic liquid of the present invention is safe to use. When the sensitive skin barrier repair compositions obtained in Examples 1-3 were used in human skin patch tests according to the above method, similar test results were obtained.

[0046] Test Example 2 Fifty healthy volunteers were selected and randomly divided into five groups of 10 each: a blank control group, a positive control group, and groups 1-3 of the examples.

[0047] Test method: Three 3cm × 3cm areas were randomly marked on the inner forearm of the subjects as test areas. Photographs of the inner forearm were taken, and the Erythema Index (EI) was measured. Transparent tape was used to peel off the test areas, repeating the peeling process 10 times for each area. After peeling, 1 mL of the sensitive skin barrier repair composition prepared in Examples 1-3 was evenly applied to each test area. The positive control group received a commercially available similar product, while the blank control group received deionized water. After 30 minutes, the tape was washed off, and subsequent testing began once the surface was dry and free of residue. The Erythema Index (EI) was measured again, and the average value of the three test areas was taken. The rate of change in EI value was calculated. The results are shown in Table 2.

[0048] Table 2

[0049] As can be seen from the table above, the sensitive skin barrier repair compositions prepared in Examples 1-3 of this invention have a good effect on repairing sensitive skin.

[0050] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A sensitive skin barrier repair composition, characterized in that, It includes the following components by weight percentage: polysaccharide 1.5-5%, peptide 0.0001-0.01%, carotenoid 0.1-1%, unsaturated fatty acid 3-10%, algae extract 1-3%, and matrix components up to 100%.

2. The composition according to claim 1, characterized in that, The polysaccharide component is selected from at least one of glycerol glucoside, trehalose, fucoidan, and mannose.

3. The composition according to claim 1, characterized in that, The peptide components are selected from at least one of Spirulina peptides, Euglena peptides, Haematococcus pluvialis active peptides, Dunaliella salina active peptides, and diatom active peptide complexes.

4. The composition according to claim 1, characterized in that, The carotenoid component is selected from at least one of astaxanthin, fucoxanthin, lycopene, β-carotene, and lutein.

5. The composition according to claim 1, characterized in that, The unsaturated fatty acid component is selected from at least one of jojoba oil, flaxseed oil, olive oil, sunflower seed oil, and sea buckthorn fruit oil.

6. The composition according to claim 1, characterized in that, The algae extract component is selected from at least one of Spirulina extract, Phlox subulata extract, Chlorella extract, and Haematococcus pluvialis extract.

7. The composition according to claim 1, characterized in that, The matrix components include deionized water, butanediol, p-hydroxyacetophenone, 1,2-hexanediol, emulsifier, and thickener, in a mass ratio of 100:2-4:0.01-0.015:1-3:2-4:3-5; the emulsifier is carbomer; and the thickener is carboxymethyl cellulose.

8. A method for preparing a sensitive skin barrier repair composition as described in any one of claims 17, characterized in that, Includes the following steps: (1) Heat and mix the unsaturated fatty acid components until homogeneous to obtain the oil phase; (2) The polysaccharide component, peptide component, carotenoid component and algae extract component are mixed and added to the matrix component, and stirred and mixed evenly to obtain an aqueous phase; (3) The oil phase was added to the aqueous phase under stirring conditions and homogenized and emulsified to obtain a sensitive skin barrier repair composition.

9. The preparation method according to claim 8, characterized in that, The heating temperature is 50-70℃, the homogenization speed is 10000-12000 r / min, and the time is 15-25 min.

10. The use of a sensitive skin barrier repair composition as described in any one of claims 17 in a cosmetic for improving the condition of sensitive skin.

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