Preparation method of hericium erinaceus polysaccharide freeze-dried flash release tablet

Abstract

The invention relates to the technical field of health-care food and medicinal preparations, in particular to a preparation method of a hericium erinaceus polysaccharide freeze-dried flash-release tablet. The hericium erinaceus polysaccharide freeze-dried flash release tablet is prepared from the following raw materials in parts by weight: 4-6 parts of hericium erinaceus polysaccharide; a skeleton supporting agent: 7-9 parts of mannitol; the adhesive is 2.2-2.8 parts of a compound of pullulan and gelatin (preferably in a ratio of 2: 1); comprising the following steps: S1, dissolving ingredients; s2, high-speed emulsification; s3, carrying out vacuum degassing; s4, performing quantitative filling; s5, performing ultralow-temperature quick freezing; s6, performing programmed freeze drying; s7, aluminum-aluminum sealed packaging is conducted; the core of the invention is to solve the problem of moisture absorption through specific adhesive compounding, and has the advantages of targeted maintenance, moisture absorption innovation resistance and zero burden on intestines and stomach.

Description

Technical Field

[0001] This invention relates to the field of health food and pharmaceutical preparation technology, specifically a method for preparing freeze-dried flash-release tablets of Hericium erinaceus polysaccharide. Background Technology

[0002] Hericium erinaceus polysaccharide is a recognized gastric mucosal protectant. Existing products are mostly in the form of ordinary tablets or granules, which have the following shortcomings: 1. Inconvenient dosage form: Powders need to be brewed and tablets need to be taken with water, which is not conducive to immediate use by patients with stomach problems.

[0003] 2. Excipient irritation: The large amount of excipients in traditional tablets may put an extra burden on sensitive stomachs.

[0004] 3. Technical bottleneck: Hericium erinaceus polysaccharide itself is hygroscopic. Direct use in freeze-drying process can easily lead to product moisture absorption, softening, structural collapse, and extremely poor storage stability. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a freeze-dried flash-release tablet of Hericium erinaceus polysaccharide with strong hygroscopic resistance, good stability, and easy administration, aiming to provide a better dosage form for stomach health care and solving the problems mentioned in the background art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: A method for preparing freeze-dried flash-release tablets of Hericium erinaceus polysaccharide, wherein the freeze-dried flash-release tablets of Hericium erinaceus polysaccharide are made from the following raw materials in the following weight ratio: 4-6 parts Hericium erinaceus polysaccharide, 7-9 parts skeleton support agent, and 2.2-2.8 parts binder; Includes the following steps: S1. Ingredient Dissolution: This includes the following steps: S11. Adhesive Dissolution: Stir the adhesive and water in a dissolving tank until completely dissolved; S12. Add the main ingredients and auxiliary ingredients, weigh the remaining raw materials into the dissolving tank according to the proportion, and stir until completely dissolved; S2, High-speed emulsification: The liquid obtained in S1 is emulsified at high speed in an emulsifier; S3, Vacuum Degassing: The emulsified liquid is degassed under vacuum.

[0007] S4. Quantitative filling: The liquid material after vacuum degassing in S3 is quantitatively filled into the bubble holes of the aluminum-plastic blister pack. S5. Ultra-low temperature quick freezing: Place the blister pack after filling with liquid into a -100℃ liquid nitrogen tunnel for pre-freezing; S6. Programmatic freeze drying: Transfer the blister packs after ultra-low temperature quick-freezing to the freeze dryer for freeze drying. S7. Aluminum-aluminum sealed packaging: Remove the blister pack from the freeze dryer, cover it with film and cut it on the sealing machine.

[0008] Compared with the prior art, the present invention provides a method for preparing freeze-dried flash-release tablets of Hericium erinaceus polysaccharide, which has the following beneficial effects: The core of this invention lies in solving the moisture absorption problem through a specific adhesive compound, which has the following advantages: 1. Targeted protection: The immediate-release formulation allows the drug to quickly reach and act on the upper digestive tract, exerting a protective effect on the stomach.

[0009] 2. Innovative anti-hygroscopic properties: By optimizing the type and ratio of binders (increasing the proportion of pullulan polysaccharide), the product's anti-hygroscopic ability has been significantly enhanced, solving the core pain point of poor stability of polysaccharide freeze-dried tablets.

[0010] 3. Zero burden on the stomach and intestines: The amount of excipients used is extremely small, avoiding additional stimulation to sensitive stomachs and intestines. Attached Figure Description

[0011] The present invention will be further described below with reference to the accompanying drawings and specific embodiments: Figure 1 The present invention provides a process flow diagram for the preparation of freeze-dried flash-release tablets of Hericium erinaceus polysaccharide. Detailed Implementation

[0012] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0013] like Figure 1 As shown, this invention provides a preparation process for freeze-dried flash-release tablets of Hericium erinaceus polysaccharide, which are made from the following raw materials in the indicated weight ratios: Hericium erinaceus polysaccharide 4-6 parts, skeleton support agent 7-9 parts, binder 2.2-2.8 parts; In this invention, Hericium erinaceus polysaccharide is the active ingredient.

[0014] In this invention, the adhesive is made from the following raw materials in the following weight ratio: 2 parts pullulan and 1 part gelatin.

[0015] In this invention, the skeleton support agent is mannitol. Example

[0016] A preparation process for Hericium erinaceus polysaccharide freeze-dried flash-release tablets, wherein the Hericium erinaceus polysaccharide freeze-dried flash-release tablets are made from the following raw materials in the indicated weight ratios: Hericium erinaceus polysaccharide 4 parts, skeleton support agent 7 parts, binder 2.2 parts; Includes the following steps: S1. Ingredient Dissolution: This includes the following steps: S11. Dissolving the adhesive: Measure purified water into a dissolving tank and heat it to 50°C. Weigh pullulan and gelatin into the dissolving tank according to the ratio of adhesive to water: 1.5-2.5:750-1250. Stir until completely dissolved. S12. Add main and auxiliary ingredients: Weigh out Hericium erinaceus polysaccharide and mannitol according to the proportion and stir in the dissolving tank until completely dissolved; S2, High-speed emulsification: The liquid obtained in S1 is emulsified at high speed in an emulsifier, specifically at an emulsifier speed of 10,000 rpm for 10 minutes; S3. Vacuum degassing: The emulsified liquid is vacuum degassed for 10 minutes.

[0017] S4. Quantitative filling: Dispense the liquid after vacuum degassing in S3 into the blister packs at 0.5ml / pieces; S5. Ultra-low temperature quick freezing: Place the blister pack after filling with liquid into a -100℃ liquid nitrogen tunnel for pre-freezing for 10 minutes; S6. Programmatic freeze drying: Transfer the blister packs after ultra-low temperature quick-freezing to the freeze dryer for freeze drying.

[0018] The freeze-drying curve for the freeze-drying treatment is as follows: -35℃ / 75min→-25℃ / 180min→-15℃ / 135min→-5℃ / 75min→25℃ / 180min.

[0019] S7. Aluminum-aluminum sealed packaging: Remove the blister pack from the freeze dryer, cover it with film and cut it on the sealing machine. Example

[0020] A preparation process for Hericium erinaceus polysaccharide freeze-dried flash-release tablets, wherein the Hericium erinaceus polysaccharide freeze-dried flash-release tablets are made from the following raw materials in the indicated weight ratios: Hericium erinaceus polysaccharide 5 parts, skeleton support agent 8 parts, binder 2.5 parts; Includes the following steps: S1. Ingredient Dissolution: This includes the following steps: S11. Dissolving the adhesive: Measure purified water into a dissolving tank and heat it to 50°C. Weigh pullulan and gelatin into the dissolving tank according to the ratio of adhesive to water: 1.5-2.5:750-1250. Stir until completely dissolved. S12. Add main and auxiliary ingredients: Weigh out Hericium erinaceus polysaccharide and mannitol according to the proportion and stir in the dissolving tank until completely dissolved; S2, High-speed emulsification: The liquid obtained in S1 is emulsified at high speed in an emulsifier, specifically at an emulsifier speed of 10,000 rpm for 10 minutes; S3. Vacuum degassing: The emulsified liquid is vacuum degassed for 10 minutes.

[0021] S4. Quantitative filling: Dispense the liquid after vacuum degassing in S3 into the blister packs at 0.5ml / pieces; S5. Ultra-low temperature quick freezing: Place the blister pack after filling with liquid into a -100℃ liquid nitrogen tunnel for pre-freezing for 10 minutes; S6. Programmatic freeze drying: Transfer the blister packs after ultra-low temperature quick-freezing to the freeze dryer for freeze drying.

[0022] The freeze-drying curve for the freeze-drying treatment is as follows: -35℃ / 75min→-25℃ / 180min→-15℃ / 135min→-5℃ / 75min→25℃ / 180min.

[0023] S7. Aluminum-aluminum sealed packaging: Remove the blister pack from the freeze dryer, cover it with film and cut it on the sealing machine. Example

[0024] A preparation process for Hericium erinaceus polysaccharide freeze-dried flash-release tablets, wherein the Hericium erinaceus polysaccharide freeze-dried flash-release tablets are made from the following raw materials in the indicated weight ratios: Hericium erinaceus polysaccharide 6 parts, skeleton support agent 9 parts, binder 2.8 parts; Includes the following steps: S1. Ingredient Dissolution: This includes the following steps: S11. Dissolving the adhesive: Measure purified water into a dissolving tank and heat it to 50°C. Weigh pullulan and gelatin into the dissolving tank according to the ratio of adhesive to water: 1.5-2.5:750-1250. Stir until completely dissolved. S12. Add main and auxiliary ingredients: Weigh out Hericium erinaceus polysaccharide and mannitol according to the proportion and stir in the dissolving tank until completely dissolved; S2, High-speed emulsification: The liquid obtained in S1 is emulsified at high speed in an emulsifier, specifically at an emulsifier speed of 10,000 rpm for 10 minutes; S3. Vacuum degassing: The emulsified liquid is vacuum degassed for 10 minutes.

[0025] S4. Quantitative filling: Dispense the liquid after vacuum degassing in S3 into the blister packs at 0.5ml / pieces; S5. Ultra-low temperature quick freezing: Place the blister pack after filling with liquid into a -100℃ liquid nitrogen tunnel for pre-freezing for 10 minutes; S6. Programmatic freeze drying: Transfer the blister packs after ultra-low temperature quick-freezing to the freeze dryer for freeze drying.

[0026] The freeze-drying curve for the freeze-drying treatment is as follows: -35℃ / 75min→-25℃ / 180min→-15℃ / 135min→-5℃ / 75min→25℃ / 180min.

[0027] S7. Aluminum-aluminum sealed packaging: Remove the blister pack from the freeze dryer, cover it with film and cut it on the sealing machine.

[0028] This invention has the advantages of convenient administration, rapid absorption, pure formula, good stability, and excellent taste.

[0029] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0030] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A method for preparing freeze-dried flash-release tablets of Hericium erinaceus polysaccharide, characterized in that: The freeze-dried flash-release tablets of Hericium erinaceus polysaccharide are made from the following raw materials in the indicated weight ratios: Hericium erinaceus polysaccharide 4-6 parts, skeleton support agent 7-9 parts, and binder 2.2-2.8 parts; Includes the following steps: S1. Ingredient Dissolution: This includes the following steps: S11. Adhesive Dissolution: Stir the adhesive and water in a dissolving tank until completely dissolved; S12. Add main and auxiliary materials: Weigh the remaining raw materials into the dissolving tank according to the proportion and stir until completely dissolved; S2, High-speed emulsification: The liquid obtained in S1 is emulsified at high speed in an emulsifier; S3, Vacuum Degassing: The emulsified liquid is degassed under vacuum; S4. Quantitative filling: The liquid material after vacuum degassing in S3 is quantitatively filled into the bubble holes of the aluminum-plastic blister pack. S5. Ultra-low temperature quick freezing: Place the blister pack after filling with liquid into a -100℃ liquid nitrogen tunnel for pre-freezing; S6. Programmatic freeze drying: Transfer the blister packs after ultra-low temperature quick-freezing to the freeze dryer for freeze drying. S7. Aluminum-aluminum sealed packaging: Remove the blister pack from the freeze dryer, cover it with film and cut it on the sealing machine.

2. The method for preparing freeze-dried flash-release tablets of Hericium erinaceus polysaccharide according to claim 1, characterized in that, Hericium erinaceus polysaccharide is the active ingredient.

3. The method for preparing freeze-dried flash-release tablets of Hericium erinaceus polysaccharide according to claim 1, characterized in that, The adhesive is made from the following raw materials in the following weight ratio: 2 parts pullulan and 1 part gelatin.

4. The method for preparing freeze-dried flash-release tablets of Hericium erinaceus polysaccharide according to claim 1, characterized in that, The skeletal support agent is mannitol.

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