Application of miR-145-5P in preparation of medicine for preventing and / or treating pseudorabies virus infection related diseases

In vitro and in vivo experiments revealed the negative regulatory role of miR-145-5p in PRV infection. The application of miR-145-5p to inhibit viral replication and promote cell apoptosis solved the problem of decreased efficacy of traditional vaccines and provided a new antiviral strategy.

CN122056911APending Publication Date: 2026-05-19YUNNAN AGRICULTURAL UNIVERSITY +1
0 Cites 0 Cited by

Patent Information

Application Number
CN202610119847.4
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-28
Publication Date
2026-05-19

AI Technical Summary

Technical Problem

Existing antiviral drugs have reduced protective efficacy against pseudorabies virus (PRV) variants, and there are frequent cases of traditional vaccine immunization failure. There is a lack of effective new antiviral strategies, and the role of miR-145-5p in PRV infection has not been systematically studied.

Method used

Through in vitro and in vivo experiments, we revealed the negative regulatory role of miR-145-5p in PRV infection. We used miR-145-5p and related products as drugs or diagnostic reagents, utilized miR-145-5p mimics or agonists to inhibit viral replication, and limited viral spread through the apoptosis pathway.

Benefits of technology

miR-145-5p significantly inhibits PRV replication and exhibits a tissue-specific response. By promoting apoptosis, it limits viral spread, providing a novel broad-spectrum antiviral strategy and offering a new direction for the diagnosis and treatment of PRV infection.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention relates to application of miR-145-5P in preparation of a medicine for preventing and / or treating PRV (pseudorabies virus) infection related diseases, and belongs to the field of biological medicines. The miR-145-5p is found to be a key differential expression molecule in the PRV infected piglet lung and colon tissue exosome through high-throughput sequencing for the first time. In-vitro cell experiments prove that up-regulation of the expression of the miR-145-5p can significantly play an antiviral role through double mechanisms of inhibiting PRV virus replication and promoting apoptosis of infected cells, and research results of the invention provide a brand new target and strategy for prevention and treatment of PRV.
Need to check novelty before this filing date? Find Prior Art