A uric acid-lowering composition, preparation and its application

Abstract

The present invention provides a uric acid-lowering composition, which contains the following components in parts by weight: 30-40 parts of dried cultured snow lotus, 20-25 parts of maca powder, 10-20 parts of aqueous extract of cistanche, 10-20 parts of aqueous extract of wolfberry, 10-20 parts of aqueous extract of turmeric, 5-10 parts of aqueous extract of gardenia, 5-10 parts of aqueous extract of mulberry leaf, 5-10 parts of aqueous extract of lophatherum gracile, and 5-10 parts of aqueous extract of coix seed. The present invention also provides an oral solid preparation or liquid preparation containing the composition, as well as food and health food. The composition provided by the present invention can effectively achieve the effect of reducing uric acid and creatinine levels, providing a potential solution for the development of drugs for reducing uric acid, preventing and treating gout and gouty kidney diseases, and has important market value and development prospects.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine and food technology, specifically relating to a uric acid-lowering composition, as well as oral preparations, foods and health foods containing the composition, and the application of the composition in the preparation of pharmaceuticals. Technical Background Hyperuricemia and gout have become increasingly serious public health problems worldwide, with their incidence rising year by year, posing a serious threat to human health. Modern medicine primarily relies on chemical drugs to treat hyperuricemia, such as xanthine oxidase inhibitors (allopurinol, febuxostat) and uricosuric drugs (benzbromarone, probenecid). While these drugs can effectively lower blood uric acid levels in the short term, long-term use is often accompanied by significant adverse reactions, including severe hypersensitivity syndrome potentially caused by allopurinol, cardiovascular risks associated with febuxostat, and hepatotoxicity from benzbromarone. Furthermore, some patients experience poor tolerance, inadequate efficacy, or contraindications to existing chemical drugs, leading to decreased treatment adherence.

[0002] Based on the above situation, discovering safe and effective uric acid-lowering drugs from the treasure trove of traditional Chinese medicine has significant practical importance and broad market prospects. Traditional Chinese medicine has a long history of treating gout and hyperuricemia, with numerous related discussions and effective prescriptions accumulated in medical texts throughout history. Modern pharmacological research has also confirmed that many active ingredients in traditional Chinese medicine, such as flavonoids, saponins, and alkaloids, have the effects of inhibiting uric acid production, promoting uric acid excretion, or anti-inflammatory and analgesic effects, with relatively few toxic side effects, making them suitable for long-term use. Therefore, developing a scientifically formulated, effective, and safe traditional Chinese medicine uric acid-lowering combination can not only provide new treatment options for clinical practice and meet unmet clinical needs, but also fully leverage the unique advantages of traditional Chinese medicine in the prevention and treatment of chronic diseases, promoting the modernization and internationalization of traditional Chinese medicine, and possessing significant social and economic value. Summary of the Invention

[0003] In order to overcome the shortcomings of the prior art, the present invention provides a composition, preparation and application of the multi-pathway synergistic reduction of uric acid and prevention of gout in related products.

[0004] In a first aspect, the present invention provides a uric acid-lowering composition comprising the following components in parts by weight: 30-40 parts dried snow lotus culture, 20-25 parts maca powder, 10-20 parts water extract of Cistanche deserticola, 10-20 parts water extract of turmeric, 5-10 parts water extract of gardenia, 5-10 parts water extract of mulberry leaf, 5-10 parts water extract of Lophatherum gracile, and 5-10 parts water extract of Coix lacryma-jobi. The composition is formed by directly mixing the above components.

[0005] The composition provided by the present invention combines the traditional Chinese medicine's theory of the nature, flavor, meridian tropism and the research results of Western pharmacology. Specifically: In the composition provided by the present invention, snow lotus warms yang and dispels dampness as the monarch drug; maca, cistanche, and turmeric warm and tonify the liver and kidney, promote qi circulation and relieve pain as the minister drugs; gardenia, mulberry leaf, and lophatherum clear heat and detoxify dampness as the assistant drugs, and coix seed invigorates the spleen and dispels dampness as the messenger drug. On this basis, the dosages of each component are further optimized to enable the components to act together to achieve synergistic enhancement and balance of restraint.

[0006] The snow lotus culture used in the present invention is a new food raw material. Its dried product specifically refers to: by using the method of plant cell culture, selecting the in vitro tissue of Saussurea involucrata Kar. et Kir. in the Compositae family, and using the callus formed after dedifferentiation as the subculture seeds, and carrying out subculture to obtain a lump-like granule, and the powder obtained by drying and pulverizing this granule.

[0007] The maca powder used in the present invention is a new food raw material, specifically referring to the powder made from the rhizomes of the artificially cultivated Lepidium meyenii Walp in the Lepidium genus of the Brassicaceae family through the processes of slicing, drying, and pulverizing.

[0008] The cistanche used in the present invention is a substance that is both a food and a traditional Chinese medicine according to tradition. Specifically, it refers to the fleshy stem of Cistanche deserticola Y. C. Ma with scaly leaves in the Orobanchaceae family. According to the "Chinese Pharmacopoeia (2025)", cistanche has a sweet, salty, and warm nature; it belongs to the kidney and large intestine meridians; it has the functions of tonifying kidney yang, nourishing essence and blood, moistening the intestine and relieving constipation, etc.; it is mainly used for kidney yang deficiency, essence and blood deficiency, impotence and infertility, weakness of the waist and knees, weakness of the muscles and bones, and intestinal dryness and constipation. The water extract of cistanche is prepared by using traditional Chinese medicine cistanche as the raw material, adding water equivalent to 20 times its mass, and extracting by the method of decocting with water, and the obtained extract is concentrated and dried. Cistanche deserticola Y. C. Ma with scaly leaves in the Orobanchaceae family. According to the "Chinese Pharmacopoeia (2025)", cistanche has a sweet, salty, and warm nature; it belongs to the kidney and large intestine meridians; it has the functions of tonifying kidney yang, nourishing essence and blood, moistening the intestine and relieving constipation, etc.; it is mainly used for kidney yang deficiency, essence and blood deficiency, impotence and infertility, weakness of the waist and knees, weakness of the muscles and bones, and intestinal dryness and constipation. The water extract of cistanche is prepared by using traditional Chinese medicine cistanche as the raw material, adding water equivalent to 20 times its mass, and extracting by the method of decocting with water, and the obtained extract is concentrated and dried.

[0009] The turmeric used in the present invention is a substance that is both a food and a traditional Chinese medicine according to tradition. Specifically, it refers to the dried rhizome of Curcuma longa L. in the Zingiberaceae family. According to the "Chinese Pharmacopoeia (2025)", turmeric has a pungent, bitter, and warm nature; it belongs to the spleen and liver meridians; it has the effects of promoting blood circulation to remove blood stasis, promoting qi circulation and dredging collaterals, etc.; it is mainly used for chest and hypochondrium stabbing pain, chest impediment pain, dysmenorrhea and amenorrhea, masses, rheumatic pain in the shoulder and arm, and traumatic swelling and pain. The water extract of turmeric is prepared by using traditional Chinese medicine turmeric as the raw material, adding water equivalent to 20 times its mass, and extracting by the method of decocting with water, and the obtained extract is concentrated and dried. Curcuma longa L. in the Zingiberaceae family. According to the "Chinese Pharmacopoeia (2025)", turmeric has a pungent, bitter, and warm nature; it belongs to the spleen and liver meridians; it has the effects of promoting blood circulation to remove blood stasis, promoting qi circulation and dredging collaterals, etc.; it is mainly used for chest and hypochondrium stabbing pain, chest impediment pain, dysmenorrhea and amenorrhea, masses, rheumatic pain in the shoulder and arm, and traumatic swelling and pain. The water extract of turmeric is prepared by using traditional Chinese medicine turmeric as the raw material, adding water equivalent to 20 times its mass, and extracting by the method of decocting with water, and the obtained extract is concentrated and dried.

[0010] The gardenia used in the present invention is a substance that is both a food and a traditional Chinese medicine according to tradition. Specifically, it refers to Gardenia jasminoides Ellis in the Rubiaceae family. Gardenia jasminoidesThe dried, ripe fruit of Ellis. According to the Chinese Pharmacopoeia (2025), Gardenia is bitter and cold in nature; it enters the heart, lung, and triple burner meridians; it has the effects of purging fire and relieving irritability, clearing heat and promoting diuresis, cooling blood and detoxifying; it is mainly used for feverish irritability, damp-heat jaundice, painful urination, hematemesis due to blood heat, red and swollen eyes, and carbuncles due to fire toxin; it is also used externally for sprains and contusions. The Gardenia water extract is obtained by using Gardenia as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0011] The mulberry leaves used in this invention are a substance that is traditionally both a food and a Chinese medicinal material, specifically referring to the mulberry tree (Morus alba). White mulberry The dried leaves of L. According to the Chinese Pharmacopoeia (2025), mulberry leaves are sweet, bitter, and cold in nature; they enter the lung and liver meridians; they have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, and clearing the liver and improving eyesight; they are mainly used for wind-heat colds, dry cough due to lung heat, dizziness, headache, and red and blurred vision. The mulberry leaf water extract is obtained by using mulberry leaves as raw material, adding water equivalent to 20 times their weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0012] The raw material used in this invention, Lophatherum gracile, is a substance that is traditionally both a food and a Chinese medicinal herb; specifically, it refers to the leaves of the Lophatherum gracile plant, a member of the Poaceae family. Lophatherum gracile The dried stems and leaves of *Brongn.*. According to the *Chinese Pharmacopoeia (2025)*, *Lophatherum gracile* is sweet, bland, and cold in nature; it enters the heart, stomach, and small intestine meridians; it has the effects of clearing heat and purging fire, relieving irritability and quenching thirst, and promoting urination; it is mainly used for feverish thirst, scanty and painful urination, and sores in the mouth and tongue. The water extract of *Lophatherum gracile* is obtained by using *Lophatherum gracile* as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0013] The raw material used in this invention, Job's tears, is a substance that is traditionally both a food and a Chinese medicinal material; specifically, it refers to the Job's tears plant (a member of the Poaceae family). Coix lacryma-jobi L. var. mayuen The dried, mature seeds of (Roman.) Stapf. According to the Chinese Pharmacopoeia (2025), Coix seed is sweet, bland, and cool in nature; it enters the spleen, stomach, and lung meridians; it has the functions of promoting diuresis and eliminating dampness, strengthening the spleen and stopping diarrhea, relieving numbness, draining pus, detoxifying and dispersing nodules; it is mainly used for edema, beriberi, dysuria, spleen deficiency diarrhea, dampness-induced numbness and contracture, lung abscess, intestinal abscess, warts, and cancer. The Coix seed water extract is obtained by using the Chinese medicinal herb Coix seed as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0014] As a preferred embodiment of the present invention, the composition may further include wolfberry, which, together with maca, cistanche, and turmeric in the composition, synergistically exerts the functions of warming and tonifying the liver and kidneys, promoting qi circulation and relieving pain, thus enhancing the overall efficacy of the composition. Specifically, the composition further includes 5-10 parts of wolfberry.

[0015] The raw material used in this invention is wolfberry, a substance that is traditionally both a food and a Chinese medicinal herb, specifically referring to *Lycium barbarum*, a plant belonging to the Solanaceae family. Lycian barbarian The dried, ripe fruit of *Lycium barbarum* (L.) is a substance traditionally used as both food and medicinal material. According to the *Chinese Pharmacopoeia (2025)*, *Lycium barbarum* is sweet and neutral in nature, and enters the liver and kidney meridians; it has the effects of nourishing the liver and kidneys, benefiting essence and improving eyesight; it is mainly used for deficiency of essence and blood, soreness of the waist and knees, dizziness and tinnitus, impotence and seminal emission, internal heat and thirst, blood deficiency and chlorosis, and blurred vision. The *Lycium barbarum* water extract is obtained by using *Lycium barbarum* as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0016] As a preferred embodiment of the present invention, the composition may further include chicory and amla, which, together with gardenia, mulberry leaf, and bamboo leaf in the composition, synergistically exert the function of clearing heat and detoxifying, thus enhancing the overall efficacy of the composition. Specifically, the composition also includes the following components in parts by weight: 2-5 parts of chicory water extract and 2-5 parts of amla water extract.

[0017] The raw material used in this invention, chicory, is a substance that is traditionally both a food and a Chinese medicinal material; specifically, it refers to the plant *Chicorylia officinalis*, belonging to the Asteraceae family. Chicory glandular Boiss. et Huet or chicory Chicory intybus The dried aerial parts of *L.*. According to the Chinese Pharmacopoeia (2025), chicory is slightly bitter and salty in taste, and cool in nature; it enters the liver, gallbladder, and stomach meridians; it has the functions of clearing the liver and gallbladder, strengthening the stomach and promoting digestion, and promoting diuresis and reducing swelling; it is mainly used for damp-heat jaundice, stomach pain with poor appetite, edema with scanty urine. The chicory water extract is obtained by using the Chinese medicinal herb chicory as raw material, adding water equivalent to 20 times its weight, and extracting by water decoction method. The resulting extract is then concentrated and dried.

[0018] The raw material used in this invention, Phyllanthus emblica, is a substance that is traditionally both a food and a Chinese medicinal herb; specifically, it refers to Phyllanthus emblica, a plant belonging to the Euphorbiaceae family. Phyllanthus emblica The dried, ripe fruit of *L.*. According to the Chinese Pharmacopoeia (2025), *Phyllanthus emblica* is sweet, sour, and astringent in nature, and cool in nature; it enters the lung and stomach meridians; it has the functions of clearing heat and cooling blood, promoting digestion and strengthening the stomach, and promoting body fluid and relieving cough; it is mainly used for blood heat and blood stasis, indigestion, abdominal distension, cough, sore throat, and dry mouth. The water extract of *Phyllanthus emblica* is obtained by using *Phyllanthus emblica* as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0019] As a preferred embodiment of the present invention, the composition may further include kudzu root and poria cocos, which, together with coix seed in the composition, exert a synergistic effect in strengthening the spleen and removing dampness, thereby enhancing the overall efficacy of the composition. Specifically, the composition also includes the following components in parts by weight: 3-8 parts of kudzu root water extract and 3-8 parts of poria cocos water extract.

[0020] The raw material used in this invention, kudzu root, is a substance that is traditionally both a food and a Chinese medicinal herb, specifically referring to the legume plant *Pueraria lobata* (also known as wild kudzu). Lobed Pueraria The dried root of *Kudzu* (Willd.) Ohwi. According to the *Chinese Pharmacopoeia (2025)*, kudzu root is sweet and pungent in taste; cool in nature; and enters the spleen, stomach, and lung meridians. It has the effects of relieving muscle tension and reducing fever, promoting body fluid production and quenching thirst, promoting rash eruption, raising yang and stopping diarrhea, clearing the meridians and activating collaterals, and detoxifying alcohol. The kudzu root water extract is obtained by using kudzu root as raw material, adding water equivalent to 20 times its weight, and extracting by decoction. The resulting extract is then concentrated and dried.

[0021] The raw material used in this invention, Poria cocos, is a substance that is traditionally both a food and a Chinese medicinal material; specifically, it refers to the fungus Poria cocos of the Polyporaceae family. Poria cocos The dried sclerotium of (Schw.) Wolf. According to the Chinese Pharmacopoeia (2025), Poria cocos is sweet, bland, and neutral in nature; it enters the heart, lung, spleen, and kidney meridians; it has the functions of promoting diuresis and eliminating dampness, strengthening the spleen, and calming the mind; it is mainly used for edema with scanty urine, phlegm retention with dizziness and palpitations, spleen deficiency with poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia. The Poria cocos water extract is obtained by using Poria cocos as raw material, adding water equivalent to 20 times its weight, and extracting it by decoction. The resulting extract is then concentrated and dried.

[0022] As the most preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 32-35 parts of dried snow lotus culture, 20-23 parts of maca powder, 12-15 parts of water extract of Cistanche deserticola, 12-15 parts of water extract of Lycium barbarum, 12-15 parts of water extract of Curcuma longa, 5-7 parts of water extract of Gardenia jasminoides, 8-10 parts of water extract of Morus alba leaves, 6-8 parts of water extract of Lophatherum gracile, 2-4 parts of water extract of Chicoryca oleracea, 2-4 parts of water extract of Phyllanthus emblica, 5-7 parts of water extract of Coix lacryma-jobi, 4-6 parts of water extract of Pueraria lobata, and 4-6 parts of water extract of Poria cocos.

[0023] In a second aspect, the present invention provides an oral solid dosage form comprising the composition described in the first aspect, and an appropriate amount of excipients acceptable in the food, health food, or pharmaceutical fields.

[0024] In one specific embodiment of the present invention, the oral solid dosage form is a tablet, preferably a regular tablet, lozenge, chewable tablet, dispersible tablet or effervescent tablet.

[0025] In one specific embodiment of the present invention, the oral solid dosage form is a capsule, preferably a hard capsule or a soft capsule.

[0026] In one specific embodiment of the present invention, the oral solid dosage form is a granule, preferably a soluble granule, a suspension granule, or an effervescent granule.

[0027] In one specific embodiment of the present invention, the oral solid dosage form is a powder.

[0028] In one specific embodiment of the present invention, the oral solid dosage form is a paste.

[0029] In one specific embodiment of the present invention, the oral solid dosage form is a candy, preferably selected from hard candies, hard-filled candies, cream candies, gel candies, gum-based candies, aerated candies, or compressed candies. When the oral dosage form is a compressed candy, xylitol is preferably used as the sweetener.

[0030] Thirdly, the present invention provides an oral liquid formulation comprising the composition described in the first aspect, and an appropriate amount of excipients acceptable in the food, health food, or pharmaceutical fields.

[0031] In one specific embodiment of the present invention, the oral liquid preparation is a syrup.

[0032] In one specific embodiment of the present invention, the oral liquid preparation is an alcoholic beverage.

[0033] In one specific embodiment of the present invention, the oral liquid preparation is an oral liquid.

[0034] In one specific embodiment of the present invention, the oral liquid preparation is a beverage.

[0035] Fourthly, the present invention provides a food product comprising the composition described in the first aspect, the oral solid dosage form described in the second aspect, or the oral liquid dosage form described in the third aspect.

[0036] Fifthly, the present invention provides a health food product comprising the composition described in the first aspect, the oral solid dosage form described in the second aspect, or the oral liquid dosage form described in the third aspect.

[0037] The composition provided by this invention uses all raw materials that are substances that are both food and traditional Chinese medicine or new food raw materials (new resource foods) published by health administration departments. It can be used in food or health food, and has high safety and low toxicity and side effects.

[0038] In a sixth aspect, the present invention provides the use of the composition described in the first aspect, the oral solid dosage form described in the second aspect, or the oral liquid dosage form described in the third aspect in the preparation of medicaments for lowering uric acid and / or preventing and treating gout.

[0039] This invention demonstrates through experiments that the composition provided can effectively reduce the levels of uric acid and creatinine in the blood. Uric acid, as the end product of purine metabolism, is mainly excreted through the kidneys; high uric acid levels can lead to kidney damage and elevated creatinine levels. When uric acid levels exceed its solubility in the blood, it precipitates as crystals and deposits in organs and tissues such as joint cavities and kidneys, leading to diseases such as gout and gouty nephropathy. Therefore, the composition provided in this application can effectively reduce uric acid levels and alleviate kidney damage, providing a potential solution for developing drugs to lower uric acid levels and prevent and treat gout and gouty nephropathy.

[0040] As a preferred embodiment of the present invention, the composition achieves the functions of lowering uric acid and / or preventing and treating gout by protecting kidney function and / or alleviating kidney damage.

[0041] Compared with existing technologies, the composition provided by this invention combines traditional Chinese medicine compatibility theory with modern pharmacological research results, enabling the components to complement and enhance each other in terms of their mechanism of action. This results in an overall efficacy of the composition that is far greater than the simple sum of the individual effects of the components. The raw materials selected for this invention are all nationally approved medicinal and edible substances or new food ingredients, exhibiting high safety, low toxicity and side effects, and a wide range of sources, thus possessing significant market value and development prospects. Detailed Implementation

[0042] The present invention provides the following embodiments to further illustrate various aspects of the invention. These embodiments are non-limiting and should not be construed as limiting any aspect of the invention. The scope of protection of the present invention is limited only by the claims. Various modifications and improvements can be made to various aspects of the present invention by those skilled in the art without departing from the scope of the claims, and these modifications and improvements also fall within the scope of protection of the present invention.

[0043] Additionally, it should be noted that, unless otherwise specified, all materials and reagents used in the following embodiments are commonly used in the art and can be obtained through conventional commercial means; all methods used are conventional methods known to those skilled in the art.

[0044] Example The following are ingredients used in the composition of the experimental examples: The dried snow lotus culture was purchased from Dalian Puricon Biotechnology Co., Ltd.

[0045] Maca powder is prepared by the following method: take raw maca purchased from Tongrentang, slice it, dry it, and pulverize it to obtain the product.

[0046] The water extract of Cistanche deserticola was prepared by the following method: Cistanche deserticola purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the weight of the Chinese herbal medicine. The extract was collected, centrifuged and filtered, the filtrate was collected, and spray-dried to obtain the final product.

[0047] The water extract of wolfberry was prepared by the following method: wolfberry purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the weight of the wolfberry. The extract was collected, centrifuged and filtered, the filtrate was collected and spray-dried to obtain the final product.

[0048] Turmeric water extract is prepared by the following method: Turmeric purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the Chinese herbal medicine. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the extract.

[0049] Gardenia water extract is prepared by the following method: Gardenia purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the weight of the Chinese herb. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the final product.

[0050] The water extract of mulberry leaves was prepared by the following method: mulberry leaves purchased from Tongrentang were boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the weight of the Chinese medicine. The extract was collected, centrifuged and filtered, and the filtrate was collected and spray-dried to obtain the final product.

[0051] The aqueous extract of Lophatherum gracile was prepared by the following method: Lophatherum gracile purchased from Tongrentang was boiled in water for 3 times, each time for 3 hours. The total amount of water used for extraction was equivalent to 20 times the mass of the Chinese herbal medicine. The extract was collected, centrifuged and filtered, the filtrate was collected, and spray-dried to obtain the final product.

[0052] Chicory water extract is prepared by the following method: take Chinese herbal chicory purchased from Tongrentang, add water and boil to extract 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the weight of the Chinese herbal medicine. Collect the extract, centrifuge and filter, collect the filtrate, and spray dry to obtain the extract.

[0053] The aqueous extract of Phyllanthus emblica was prepared by the following method: Phyllanthus emblica purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the mass of the Chinese herb. The extract was collected, centrifuged and filtered, and the filtrate was collected and spray-dried to obtain the final product.

[0054] The water extract of Coix seed is prepared by the following method: Coix seed purchased from Tongrentang is boiled in water and extracted 3 times, each time for 3 hours. The total amount of water used for extraction is equivalent to 20 times the weight of the Chinese herb. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the final product.

[0055] The water extract of kudzu root was prepared by the following method: Kudzu root purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the weight of the Chinese herbal medicine. The extract was collected, centrifuged and filtered, and the filtrate was collected and spray-dried to obtain the final product.

[0056] The aqueous extract of Poria cocos was prepared by the following method: Poria cocos purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the mass of the Chinese herbal medicine. The extract was collected, centrifuged and filtered, and the filtrate was collected and spray-dried to obtain the final product.

[0057] Example 1 This embodiment provides a uric acid-lowering composition, which is composed of the following components: 33g of dried snow lotus culture, 22g of maca powder, 13g of water extract of Cistanche deserticola, 13g of water extract of turmeric, 6g of water extract of gardenia, 9g of water extract of mulberry leaf, 7g of water extract of Lophatherum gracile leaf, and 6g of water extract of Coix lacryma-jobi.

[0058] Example 2 This embodiment provides a uric acid-lowering composition, which is composed of the following components: 33g of dried snow lotus culture, 22g of maca powder, 13g of water extract of Cistanche deserticola, 14g of water extract of Lycium barbarum, 13g of water extract of Curcuma longa, 6g of water extract of Gardenia jasminoides, 9g of water extract of mulberry leaf, 7g of water extract of Lophatherum gracile leaf, and 6g of water extract of Coix lacryma-jobi.

[0059] Example 3 This embodiment provides a uric acid-lowering composition, which is composed of the following components: 33g of dried snow lotus culture, 22g of maca powder, 13g of water extract of Cistanche deserticola, 13g of water extract of turmeric, 6g of water extract of gardenia, 9g of water extract of mulberry leaf, 7g of water extract of Lophatherum gracile, 3g of water extract of chicory, 3g of water extract of Phyllanthus emblica, and 6g of water extract of Coix lacryma-jobi.

[0060] Example 4 This embodiment provides a uric acid-lowering composition, which is composed of the following components: 33g of dried snow lotus culture, 22g of maca powder, 13g of water extract of Cistanche deserticola, 13g of water extract of turmeric, 6g of water extract of gardenia, 9g of water extract of mulberry leaf, 7g of water extract of Lophatherum gracile leaf, 6g of water extract of Coix lacryma-jobi, 5g of water extract of kudzu root, and 5g of water extract of Poria cocos.

[0061] Example 5 This embodiment provides a uric acid-lowering composition, which is composed of the following components: 33g of dried snow lotus culture, 22g of maca powder, 13g of water extract of Cistanche deserticola, 14g of water extract of Lycium barbarum, 13g of water extract of Curcuma longa, 6g of water extract of Gardenia jasminoides, 9g of water extract of mulberry leaf, 7g of water extract of Lophatherum gracile, 3g of water extract of chicory, 3g of water extract of Phyllanthus emblica, 6g of water extract of Coix lacryma-jobi, 5g of water extract of Pueraria lobata, and 5g of water extract of Poria cocos.

[0062] Example 6 This embodiment provides a uric acid-lowering composition, which is composed of the following components: 32g of dried snow lotus culture, 23g of maca powder, 12g of water extract of Cistanche deserticola, 15g of water extract of Lycium barbarum, 12g of water extract of Curcuma longa, 7g of water extract of Gardenia jasminoides, 8g of water extract of mulberry leaf, 8g of water extract of Lophatherum gracile, 2g of water extract of chicory, 4g of water extract of Phyllanthus emblica, 5g of water extract of Coix lacryma-jobi, 6g of water extract of Pueraria lobata, and 4g of water extract of Poria cocos.

[0063] Example 7 This embodiment provides a uric acid-lowering composition, which is composed of the following components: 35g of dried snow lotus culture, 20g of maca powder, 15g of water extract of Cistanche deserticola, 12g of water extract of Lycium barbarum, 15g of water extract of Curcuma longa, 5g of water extract of Gardenia jasminoides, 10g of water extract of Morus alba leaves, 6g of water extract of Lophatherum gracile leaves, 4g of water extract of Chicory, 2g of water extract of Phyllanthus emblica, 7g of water extract of Coix lacryma-jobi, 4g of water extract of Pueraria lobata, and 6g of water extract of Poria cocos.

[0064] Example 8 This embodiment provides a granule preparation, which is prepared by the following method: 40 g of the composition provided in Example 1, 5 g of xylitol and 15 g of maltodextrin are mixed and granulated by dry granulation to obtain the granule.

[0065] In the solid beverage provided in this embodiment, the composition provided in Example 1 can be replaced with the composition provided in Examples 2 to 7, and the amount of excipients can be appropriately adjusted to obtain the corresponding granules of each embodiment composition, or it can be further processed into a solid beverage.

[0066] Example 9 This embodiment provides an oral liquid prepared by the following method: 40 g of the composition provided in Example 1, 8 g of xylitol, 0.25 g of potassium sorbate (calculated as sorbic acid), and purified water added to a total volume of 500 mL.

[0067] In the oral liquid provided in this embodiment, the composition provided in Example 1 can be replaced with the composition provided in Examples 2 to 7, and the amount of excipients can be adjusted appropriately to obtain the corresponding oral liquid of each embodiment composition, or it can be further processed into a liquid beverage.

[0068] Experimental Example Seventy SPF-grade male KM mice were randomly divided into seven groups: a control group, a model group, and groups 1-5 (Example 1, Example 2, Example 3, Example 4, and Example 5), with ten mice in each group. The test samples (Examples 1-5, all at a concentration of 20 mg / mL) were administered orally via gavage at a dose of 12 mL / kg BW for 19 consecutive days. The experimental groups (Examples 1-5) received the same concentration of the combined sample via gavage, while the control and model groups received an equal volume of physiological saline. On day 20, after a 12-hour fast with no water, all groups except the control group received an intraperitoneal injection of potassium oxonate (PO), a uricase-specific inhibitor, at a concentration of 300 mg / kg, and were also administered hypoxanthine (HX), a uric acid precursor, via gavage at a concentration of 500 mg / kg to establish a hyperuricemia mouse model. The control group received an intraperitoneal injection and gavage of an equal volume of physiological saline. Two hours after model establishment, all groups were administered the same gavage once. Mice in each group were administered the pre-modeling protocol via gavage for 10 days. Blood and serum were collected from the mice for biochemical analysis.

[0069] The serum uric acid (UA) level was measured using a kit (Nanjing Jiancheng Bioengineering Institute, C012-2-1), and the results are shown in Table 1.

[0070] Table 1: Results of serum UA concentration detection (n=10)

[0071] Serum creatinine (Cr) levels were measured using a kit (Nanjing Jiancheng Bioengineering Institute, C011-2-1). The results are shown in Table 2.

[0072] Table 2: Results of serum Cr concentration detection (n=10)

[0073] The results above show that the composition provided in this application can significantly reduce the uric acid level in the serum of hyperuricemic model mice, directly achieving the effect of lowering uric acid; it can also significantly reduce the creatinine level in the serum of hyperuricemic model mice, demonstrating its alleviating effect on kidney damage caused by hyperuricemia. Among them, Example 5 has the best overall effect, significantly better than other Examples 1-4.

[0074] Unless otherwise stated, the technical terms used herein have the same meanings as commonly understood by one of ordinary skill in the art. This invention may also be practiced using any methods and materials similar to or equivalent to those described herein. While specific embodiments and preferred methods and materials are described herein, they do not impose any limitation on the invention.

Claims

1. A uric acid-lowering composition, characterized in that, It contains the following ingredients in parts by weight: 30-40 parts dried snow lotus culture, 20-25 parts maca powder, 10-20 parts water extract of Cistanche deserticola, 10-20 parts water extract of turmeric, 5-10 parts water extract of gardenia, 5-10 parts water extract of mulberry leaf, 5-10 parts water extract of Lophatherum gracile, and 5-10 parts water extract of Coix lacryma-jobi.

2. The composition according to claim 1, characterized in that, The composition also contains 10-20 parts of wolfberry water extract.

3. The composition according to claim 1 or 2, characterized in that, The composition also contains 2-5 parts of chicory water extract and 2-5 parts of amla water extract.

4. The composition according to any one of claims 1 to 3, characterized in that, The composition also contains 3-8 parts of kudzu root water extract and 3-8 parts of poria cocos water extract.

5. The composition according to any one of claims 1 to 4, characterized in that, It contains the following ingredients in parts by weight: 32-35 parts dried snow lotus culture, 20-23 parts maca powder, 12-15 parts water extract of Cistanche deserticola, 12-15 parts water extract of Lycium barbarum, 12-15 parts water extract of turmeric, 5-7 parts water extract of gardenia, 8-10 parts water extract of mulberry leaf, 6-8 parts water extract of Lophatherum gracile, 2-4 parts water extract of chicory, 2-4 parts water extract of Phyllanthus emblica, 5-7 parts water extract of Coix lacryma-jobi, 4-6 parts water extract of kudzu root, and 4-6 parts water extract of Poria cocos.

6. An oral solid dosage form, characterized in that, The composition comprises the composition according to any one of claims 1 to 5, and excipients; preferably, The preparation is a tablet, preferably a regular tablet, lozenge, chewable tablet, dispersible tablet or effervescent tablet; Alternatively, the formulation is a capsule, preferably a hard capsule or a soft capsule; Alternatively, the formulation is a granule, preferably a soluble granule, a suspension granule or an effervescent granule; Alternatively, the preparation may be a powder; Alternatively, the formulation may be a paste; Alternatively, the preparation is a candy, preferably hard candy, hard filled candy, cream candy, gel candy, gum-based candy, aerated candy, or compressed candy.

7. An oral liquid formulation, characterized in that, The composition comprises any one of claims 1 to 5, and excipients; Preferably, the preparation is a syrup, oral liquid, alcoholic beverage, or beverage.

8. A food product, characterized in that, It comprises the composition of any one of claims 1 to 5, the oral solid dosage form of claim 6, or the oral liquid dosage form of claim 7.

9. A health food product, characterized in that, It comprises the composition of any one of claims 1 to 5, the oral solid dosage form of claim 6, or the oral liquid dosage form of claim 7.

10. The use of the composition according to any one of claims 1 to 5, the oral solid dosage form according to claim 6, or the oral liquid dosage form according to claim 7 in the preparation of a medicament for lowering uric acid and / or preventing and treating gout.

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