Ionizable lipids and uses thereof
By introducing pyrazole ring structures and ester groups into ionizable lipid compounds, the resulting lipid nanoparticles improve the delivery and encapsulation efficiency of nucleic acids, solving the problems of nucleic acid degradation and low delivery efficiency in vivo, and achieving improved stability and therapeutic efficacy of nucleic acid therapeutic agents.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- KOREA GREEN CROSS CORP
- Filing Date
- 2024-10-23
- Publication Date
- 2026-05-26
AI Technical Summary
Existing technologies struggle to effectively prevent nucleic acids from being degraded by enzymes in vivo and to deliver them to target cells, especially due to their negative charge and large molecular weight, which result in low delivery efficiency.
A novel ionizable lipid compound was synthesized by introducing a pyrazole ring structure into the head of the ionizable lipid and adding ester or branched ester groups to the terminal hydrocarbon chain to form lipid nanoparticles (LNPs) with excellent cell delivery efficiency. Phospholipids, cholesterol and PEG-lipids were then combined to stabilize and disperse nucleic acids.
This improved the delivery and encapsulation efficiency of nucleic acids, enhancing the in vivo stability and therapeutic efficacy of nucleic acid therapeutic agents.
Smart Images
Figure CN122094940A_ABST
Abstract
Citation Information
Patent Citations
Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
US20200140378A1