A feed additive for improving meat quality of ruminants and a method for preparing the same

Abstract

The present application relates to the field of feed, especially to a feed additive for improving meat quality of ruminants and a preparation method thereof; the present application forms functional complementation through a traditional Chinese medicine composition and guanidoacetic acid and magnesium ions; acanthopanax-scutellaria promotes body synthesis metabolism, and is synergistic with creatine precursors provided by guanidoacetic acid to optimize muscle energy reserves; schisandra chinensis and rhodiola enhance the body's stress resistance, and cooperate with magnesium ions to stabilize neuromuscular excitability and reduce excessive consumption of glycogen caused by pre-slaughter stress; polygonatum and polygonatum maintain cell membrane integrity in cooperation with vitamin E and the like; through the combined action of various components through multiple targets and multiple pathways, the synchronous improvement of muscle development and stress resistance is realized.

Description

Technical Field

[0001] This invention relates to the field of feed, and more particularly to a feed additive for improving the meat quality of ruminants and its preparation method. Background Technology

[0002] The pale color, high drip loss, and overall poor quality of ruminant meat (mainly beef cattle and sheep) are key bottlenecks currently hindering the development of the red meat industry. Specifically, this manifests as pale muscle color after slaughter, lacking the ideal marbling, and 24-hour drip loss far exceeding ideal levels, leading to decreased tenderness, loss of flavor compounds, and reduced processing yield. Drip loss is a crucial indicator of muscle water-holding capacity, directly impacting slaughter losses and the economic value of meat products. The mechanisms underlying these quality defects are complex, involving imbalances in multiple areas, including excessive pre-slaughter stress-induced glycogen depletion, rapid post-slaughter pH decline, lipid peroxidation of muscle cell membranes, and denaturation of myofibril structural proteins. Current technologies primarily involve passive intervention post-slaughter through physicochemical methods such as cooling rate, voltage stimulation, and phosphate addition, failing to actively regulate myofibril structural development and cell membrane stability during the rearing stage. Post-slaughter interventions suffer from limited effectiveness, food safety risks (such as excessive phosphate), and high operating costs.

[0003] Traditional Chinese medicine has a long history of application in ruminant production, but it suffers from serious problems of reliance on experience and extensive methods. Most studies directly use raw medicinal powders without targeted processing to enhance efficacy, resulting in low dissolution rates and poor bioavailability of active ingredients. Furthermore, traditional Chinese medicine lacks synergistic design with amino acids, trace elements, vitamins, etc., and simple superposition leads to antagonism or waste.

[0004] Current ruminant fattening techniques rely excessively on extensive feeding methods using high-protein, high-energy diets. While this promotes weight gain, it prioritizes quantity over quality. Traditional fattening models excessively pursue growth rate and feed conversion ratio, neglecting the precise regulation of muscle fiber development quality and metabolic homeostasis. Excessive protein metabolism leads to ammonia nitrogen burden, and excess energy causes abnormal fat deposition, both of which are detrimental to the refined development of myofibrils.

[0005] Therefore, actively regulating myofibril development, optimizing energy reserves and stress management, and strengthening cell membrane stability from the feeding stage are the inevitable paths to fundamentally improve the meat quality of ruminants. Summary of the Invention

[0006] The purpose of this invention is to address the shortcomings of existing technologies by providing a feed additive with high palatability, multi-target synergistic effect, and improved meat quality in ruminants, as well as a method for its preparation.

[0007] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0008] The first aspect of this invention is to provide a feed additive for improving the meat quality of ruminants, comprising, by weight: 6-15 parts of a traditional Chinese medicine composition, 0.6-1.8 parts of guanidinoacetic acid, 0.2-0.8 parts of a magnesium source, 1.5-5 parts of betaine, 3.5-14 parts of amino acids, 0.08-0.5 parts of yeast selenium, 0.08-0.5 parts of organic chromium, 0.2-1 part of vitamin E, 0.1-0.8 parts of vitamin C, 2-8 parts of brewer's yeast extract, and 10-25 parts of a palatability enhancer.

[0009] Each of the traditional Chinese medicine compositions comprises, by weight, 15-25 parts of Acanthopanax senticosus-Astragalus membranaceus mixture, 8-15 parts of Panax notoginseng stem and leaf extract, 8-15 parts of Schisandra chinensis water extract, 8-15 parts of Rhodiola rosea root powder, 8-15 parts of Drynaria fortunei enzymatic hydrolysate, 6-12 parts of Dipsacus asper dried powder, 6-12 parts of Polygonatum sibiricum high-pressure steamed powder, 4-8 parts of Polygonatum odoratum dried powder, and 4-8 parts of Glycyrrhiza uralensis extract.

[0010] Preferably, the magnesium source includes at least one of magnesium oxide, magnesium hydroxide, magnesium glycine, and magnesium hydroxide coating.

[0011] Preferably, the amino acid includes at least one of rumen-protected lysine and rumen-protected methionine.

[0012] Preferably, the palatability enhancer includes at least one of molasses, maltodextrin, and corn starch.

[0013] Preferably, in the Acanthopanax senticosus-Astragalus membranaceus mixture, the mass ratio of Acanthopanax senticosus to Astragalus membranaceus is (6-8):(2-4).

[0014] A second aspect of the present invention is to provide a method for preparing the feed additive as described above, comprising the steps of:

[0015] S1. After mixing Acanthopanax senticosus and Astragalus membranaceus, the mixture is honey-processed, dried, and pulverized to obtain an Acanthopanax senticosus-Astragalus membranaceus mixture; the stems and leaves of Panax notoginseng are extracted with water, concentrated, and dried to obtain Panax notoginseng stem and leaf extract; Schisandra chinensis is crushed, extracted with water, concentrated, and dried to obtain Schisandra chinensis water extract; Rhodiola rosea is washed, sliced, dried, and pulverized to obtain Rhodiola rosea root powder; Drynaria fortunei is enzymatically hydrolyzed, filtered, concentrated, and dried to obtain Drynaria fortunei enzymatic hydrolysate; Dipsacus asperoides is washed, sliced, dried, and pulverized to obtain Dipsacus asperoides dried powder; Polygonatum sibiricum is washed, sliced, high-pressure steamed, dried, and pulverized to obtain Polygonatum sibiricum high-pressure steamed powder; Polygonatum odoratum is washed, sliced, dried, and pulverized to obtain Polygonatum odoratum dried powder; Glycyrrhiza uralensis is dried and pulverized to obtain Glycyrrhiza uralensis extract; the above materials are weighed according to the weight proportions, mixed, and pulverized to obtain the Chinese herbal composition.

[0016] S2. Weigh the Chinese herbal medicine composition, guanidinoacetic acid, magnesium source, betaine, amino acids, yeast selenium, organic chromium, vitamin E, vitamin C, brewer's yeast extract and appetite stimulant according to the weight proportions, mix them, and then granulate and dry them to obtain the feed additive.

[0017] Preferably, in step S1, the honey-processing of the Acanthopanax senticosus-Astragalus membranaceus mixture includes: mixing honey and water at a ratio of 1:(0.4-0.6), heating to 116-118°C for refining, diluting by 1:1, allowing to soak for 1.5-2.5 hours, and frying at a temperature of 105-115°C.

[0018] Preferably, in step S1, the enzymatic hydrolysis for preparing the *Drynaria fortunei* hydrolysate includes: adding papain and cellulase, hydrolyzing at 50°C for 4 hours, and inactivating the enzyme at 85°C for 15 minutes.

[0019] Preferably, in step S1, the high-pressure steaming process for preparing the Polygonatum high-pressure steamed powder includes: steaming at 0.15-0.2 MPa and 110-120°C for 1-2 hours.

[0020] Preferably, in step S2, the conditioning temperature for granulation drying is 55-65°C.

[0021] The present invention adopts the above technical solution and has the following technical effects compared with the prior art:

[0022] This invention uses Acanthopanax senticosus and Astragalus membranaceus as the principal herbs to tonify Qi, strengthen the spleen, and consolidate the body's foundation; Panax notoginseng stems and leaves and Schisandra chinensis as the assistant herbs to invigorate blood, promote tissue regeneration, and astringe and consolidate; Rhodiola rosea, Drynaria fortunei, and Dipsacus as adjuvant herbs to invigorate Qi, promote blood circulation, strengthen tendons and bones; and Polygonatum sibiricum, Polygonatum odoratum, and Glycyrrhiza uralensis as guiding herbs to nourish Yin, moisten dryness, and harmonize the effects of the other herbs. The synergistic effect of these herbs forms a progressive treatment principle of tonifying both Qi and blood, strengthening tendons and bones, and protecting Yin fluids, which aligns with the theoretical system of the kidney governing bone and marrow production and the spleen governing muscles, providing a holistic regulatory basis for myofibril development.

[0023] This invention achieves functional complementarity between the traditional Chinese medicine composition and guanidinoacetic acid and magnesium ions. Acanthopanax senticosus-Astragalus membranaceus promotes the body's anabolic metabolism and works synergistically with the creatine precursor provided by guanidinoacetic acid to optimize muscle energy reserves. Schisandra chinensis and Rhodiola rosea enhance the body's stress resistance and work with magnesium ions to stabilize neuromuscular excitability and reduce excessive glycogen consumption caused by pre-slaughter stress. Polygonatum odoratum and Polygonatum sibiricum nourish yin and moisten dryness, and work synergistically with vitamin E to maintain cell membrane integrity. Through the combined action of multiple targets and pathways, the components achieve simultaneous improvement in muscle development and stress resistance.

[0024] This invention employs a combination of honey-roasting, high-pressure steaming, and enzymatic hydrolysis techniques to replace the lengthy traditional processes of nine steaming and nine sun-drying and sand-scalding, thus shortening the production cycle and improving the retention rate of active ingredients. Process optimization ensures that each functional component is effectively delivered to its target site, exerting a synergistic effect and ultimately achieving comprehensive benefits such as reducing drip loss, improving meat color and tenderness, and enhancing meat quality. Detailed Implementation

[0025] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0026] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other.

[0027] The present invention will be further described below with reference to specific embodiments, but these are not intended to limit the scope of the invention.

[0028] Example

[0029] This embodiment provides a feed additive for improving the meat quality of ruminants and its preparation method, the steps of which include:

[0030] S1. Preparation of traditional Chinese medicine composition:

[0031] S1.1 Preparation of honey-processed Acanthopanax senticosus-Astragalus membranaceus mixture: Acanthopanax senticosus slices and Astragalus membranaceus slices are mixed at a weight ratio of 7:3. 20% of the weight of the medicinal materials is added to refined honey, which is obtained by heating honey and water at a ratio of 1:0.5 to 116-118℃ and then diluting it by 1:1. After mixing well, the mixture is left to soak for 2 hours, then stir-fried at 110℃ over low heat until it turns slightly yellow and is no longer sticky. It is then dried at 60℃ until the moisture content is ≤10%, and then pulverized through a 40-mesh sieve.

[0032] S1.2 Preparation of Panax notoginseng stem and leaf extract: Take Panax notoginseng stem and leaf segments, add water and boil to extract twice, each time with a water-to-material ratio of 8:1 and a time of 2 hours, combine the filtrates, concentrate under reduced pressure and spray dry;

[0033] S1.3 Preparation of Schisandra chinensis water extract: Schisandra chinensis was crushed, boiled in water twice, with a water-to-material ratio of 8:1 and a time of 2 hours each time. The filtrates were combined, concentrated under reduced pressure, and spray-dried.

[0034] S1.4 Preparation of Rhodiola Rosea root powder: Take Rhodiola Rosea rhizomes, wash them, cut them into 5mm slices, dry them at 70℃ until the moisture content is ≤10%, and then pulverize them through a 40-mesh sieve.

[0035] S1.5 Preparation of enzymatic hydrolysate of Drynaria fortunei: Drynaria fortunei was dehaired and crushed, and water was added to adjust the pH to 5.0. Papain 0.3% and cellulase 0.2% were added, and enzymatic hydrolysis was carried out at 50℃ for 4 hours. The enzyme was inactivated at 85℃ for 15 minutes, filtered, and the filtrate was concentrated under reduced pressure and dried under vacuum.

[0036] S1.6 Preparation of dried powder of Dipsacus asperoides: Take Dipsacus asperoides, wash it, cut it into 3mm slices, dry it at 70℃ until the moisture content is ≤10%, and pulverize it through a 40-mesh sieve;

[0037] S1.7 Preparation of high-pressure steamed powder of Polygonatum: Take Polygonatum, wash, peel, cut into 5mm slices, steam at 0.15MPa and 120℃ for 2h, dry at 60℃ until the moisture content is ≤10%, and pulverize through a 40-mesh sieve.

[0038] S1.8 Preparation of Polygonatum odoratum dried powder: Take Polygonatum odoratum, wash it, cut it into 5mm slices, dry it at 70℃ until the moisture content is ≤10%, and pulverize it through a 40-mesh sieve;

[0039] S1.9 Preparation of licorice extract: Take licorice residue, dry it at 70℃ until the moisture content is ≤10%, and pulverize it through a 60-mesh sieve;

[0040] S1.10, Mixing: Weigh the products obtained from S1.1-S1.9 according to the weight proportions, put them into a mixer and mix for 20 minutes, then pass them through a 60-mesh sieve to obtain the traditional Chinese medicine composition;

[0041] S2, Mixed Granulation:

[0042] Weigh out 8 parts by weight of the traditional Chinese medicine composition, 0.8 parts by weight of guanidinoacetic acid, 0.3 parts by weight of magnesium glycine, 3 parts by weight of betaine, 3 parts by weight of rumen-protected lysine, 3 parts by weight of rumen-protected methionine, 0.1 parts by weight of yeast selenium, 0.1 parts by weight of organic chromium, 0.5 parts by weight of vitamin E, 0.5 parts by weight of vitamin C, 5 parts by weight of brewer's yeast extract, 8 parts by weight of molasses, and 10 parts by weight of corn starch. Put them into a mixer and mix for 10 minutes. Add molasses preheated to 50°C and continue mixing for 15 minutes. Then put them into the mixer and mix for a total of 20 minutes. Use a ring die pellet mill to pelletize the pellets at a conditioning temperature of 60°C, a conditioning moisture content of 12-14%, a compression ratio of 1:4, and a die diameter of 3.5 mm. Cool and dry in a countercurrent cooling manner until the moisture content drops to 8-10% to obtain the feed additive.

[0043] Comparative Example 1

[0044] This comparative example provides a feed additive that does not contain any traditional Chinese medicine composition; all other aspects are the same as in Example 1.

[0045] Detection Examples

[0046] 1. Grouping

[0047] Forty-eight beef cattle weighing around 350 kg and in the mid-to-late fattening stage were selected and randomly divided into three groups: a control group (cattle farm basal diet), Example 1 group, and Comparative Example 1 group, with 16 cattle in each group. The experiment lasted for 120 days.

[0048] Each cattle pen has identical equipment and conditions, with free access to feed and water. Deworming, disinfection, immunization, and other management practices are conducted according to normal cattle farm management methods. Record the temperature, humidity, and weather conditions inside the pens during the experimental phase. Feeding should be done until there is a slight amount of feed remaining in the troughs. Carefully observe the cattle's feeding, defecation, urination patterns, and health status. Record daily temperature, feed intake, number of cattle with diarrhea, morbidity, and mortality. Treat any abnormalities promptly and record the findings. Note that no additional antibiotics should be administered during the experiment; if medication is necessary, it must be recorded. Weigh each cattle in its pen at the beginning and end of the formal experiment and record the weight accurately.

[0049] 2. Measurement Indicators

[0050] 2.1 Production performance

[0051] Daily gain (ADG): The experimental cattle were weighed on an empty stomach before morning feeding at the beginning and end of the experiment. The weight of dead or culled cattle and the number of days they participated in the experiment were recorded during the trial to calculate the daily gain for each pen. The calculation formula is:

[0052] Daily weight gain = (End of pen weight - Initial pen weight + End of dead culled cattle weight) / (Number of remaining cattle in the pen × Total number of trial days + Number of days dead culled cattle were involved in the trial)

[0053] Daily Feed Intake (ADFI): Record the feed addition data for each column, and record the amount of feed remaining in each column at the end of the experiment. Calculate the average daily feed intake. The intake of both concentrate and forage supplements should be recorded.

[0054] Daily feed intake = (first feed addition weight + second feed addition weight + ... + last feed addition weight - remaining feed weight) / (number of cattle remaining in the pen * number of trial days + number of days of trial after cattle die).

[0055] 2.3 Meat quality determination

[0056] pH: Within 45 minutes post-mortem, the pH of the longissimus dorsi muscle was measured at three different locations using a pH meter, and the average value was taken.

[0057] Drip loss: After slaughtering the cattle, the longissimus dorsi muscle was harvested, cut into 2cm×2cm×2cm pieces, approximately 15g in weight, weighed, and recorded. A thin wire was threaded through a paper cup, then through the meat sample, and back through the paper cup, suspending the meat sample inside the cup and ensuring it remained in contact with the cup wall and bottom. The entire paper cup assembly was then tightly wrapped in a resealable bag to create a completely sealed sample storage environment. Finally, the assembled system was stored in a 4℃ constant temperature refrigerator. The meat was removed, weighed, and recorded at 24h and 48h.

[0058] Meat color: The brightness coefficient (L*) and redness coefficient (a*) of the meat samples were measured using a colorimeter. Each sample was measured 3 times and the average value was taken.

[0059] 3. Data Statistics and Analysis

[0060] Experimental data were analyzed using SPSS version 31.0 software. One-way ANOVA was used for statistical analysis, and Duncan's method was used for multiple comparisons of the means. Results are expressed as mean ± standard deviation (Mean ± SD).

[0061] 3.1 Effects on growth performance of beef cattle

[0062] As shown in Table 1, the daily weight gain in Example 1 was 24.0% higher than that in the blank control, which was significantly better than that in Comparative Example 1 and the control group. Although Comparative Example 1 had a certain effect, it was still lower than that in Example 1, which is sufficient to prove the necessity of the synergistic effect of the traditional Chinese medicine composition and its components.

[0063] Table 1

[0064]

[0065] Note: * indicates a significant difference from the blank control (P<0.05), and ** indicates an extremely significant difference (P<0.01).

[0066] 3.2 Effects on slaughter performance

[0067] As shown in Table 2, the eye muscle area of ​​Example 1 increased by 19.2% compared with the blank control group and by 9.7% compared with the control group; the backfat thickness of Example 1 was significantly lower than that of the blank control, achieving precise control of lean meat and low fat; the IMF content of Example 1 achieved the ideal effect and was significantly higher than that of the control group, indicating that the beef fed with the feed additive in Example 1 achieved the effect of targeted fat deposition.

[0068] Table 2

[0069]

[0070] 3.3 Impact on meat quality

[0071] As shown in Table 3, the drip loss in Example 1 was... 24h The pH was 48.7% lower than the blank control group and 27.8% lower than control group 1. 24h The value stabilized at 5.58, with a 9.7% decrease in the meat color L value and a 30.3% increase in the a value, indicating that the oxidation state of myoglobin was optimized, and the appearance and water-holding capacity of meat products were improved simultaneously.

[0072] Table 3

[0073]

[0074] Note: The lower the L value, the deeper the redness of the flesh (consumer preference); the higher the a value, the better the redness.

[0075] 3. Safety evaluation

[0076] Beef cattle weighing around 280 kg were selected, and the safety of the feed additive in Example 1 was evaluated. The beef cattle were divided into a blank control group, a low-dose group (0.5 times the recommended dose), a recommended dose group (28 g / head / day), and a high-dose group (2 times the recommended dose), with 18 cattle in each group. They were fed a total mixed ration with free access to feed, and their health was monitored regularly for 240 days.

[0077] 3.1 Routine blood indicators (240 days)

[0078] As shown in Table 4, the blood routine tests in all dosage groups were within the normal physiological range, with no signs of anemia, inflammation, or immunosuppression. The ratios of white blood cells, red blood cells, and lymphocytes in the recommended dosage group remained stable, indicating that long-term feeding did not have adverse effects on the body's hematopoietic function and immune status, and the product has good safety.

[0079] Table 4

[0080]

[0081] 3.2 Liver and kidney function indicators

[0082] Table 5 shows that the total protein and albumin levels in the recommended dose group were significantly higher than those in the control group, reflecting enhanced protein synthesis and metabolism, consistent with the growth-promoting effect. Although the ALT level in the high-dose group was 10.1% higher than that in the control group, it was still within the normal range. No abnormalities were found in BUN and CRE levels in any group, indicating that long-term feeding does not burden liver and kidney function and the safety is controllable.

[0083] Table 5

[0084]

[0085] The above description is merely a preferred embodiment of the present invention and does not limit the implementation and protection scope of the present invention. Those skilled in the art should realize that any equivalent substitutions and obvious changes made based on the content of this specification should be included within the protection scope of the present invention.

Claims

1. A feed additive for improving the meat quality of ruminants, characterized in that, By weight, the components include: 6-15 parts of traditional Chinese medicine composition, 0.6-1.8 parts of guanidinoacetic acid, 0.2-0.8 parts of magnesium source, 1.5-5 parts of betaine, 3.5-14 parts of amino acids, 0.08-0.5 parts of yeast selenium, 0.08-0.5 parts of organic chromium, 0.2-1 part of vitamin E, 0.1-0.8 parts of vitamin C, 2-8 parts of brewer's yeast extract, and 10-25 parts of appetite stimulant. Each of the traditional Chinese medicine compositions comprises, by weight, 15-25 parts of Acanthopanax senticosus-Astragalus membranaceus mixture, 8-15 parts of Panax notoginseng stem and leaf extract, 8-15 parts of Schisandra chinensis water extract, 8-15 parts of Rhodiola rosea root powder, 8-15 parts of Drynaria fortunei enzymatic hydrolysate, 6-12 parts of Dipsacus asper dried powder, 6-12 parts of Polygonatum sibiricum high-pressure steamed powder, 4-8 parts of Polygonatum odoratum dried powder, and 4-8 parts of Glycyrrhiza uralensis extract.

2. The feed additive according to claim 1, characterized in that, The magnesium source includes at least one of magnesium oxide, magnesium hydroxide, magnesium glycine, and magnesium hydroxide coating.

3. The feed additive according to claim 1, characterized in that, The amino acid includes at least one of rumen-protected lysine and rumen-protected methionine.

4. The feed additive according to claim 1, characterized in that, The palatability enhancer includes at least one of molasses, maltodextrin, and corn starch.

5. The feed additive according to claim 1, characterized in that, In the Acanthopanax senticosus-Astragalus membranaceus mixture, the mass ratio of Acanthopanax senticosus to Astragalus membranaceus is (6-8):(2-4).

6. A method for preparing a feed additive as described in any one of claims 1-5, characterized in that, step... include: S1. After mixing Acanthopanax senticosus and Astragalus membranaceus, the mixture is honey-processed, dried, and pulverized to obtain an Acanthopanax senticosus-Astragalus membranaceus mixture; the stems and leaves of Panax notoginseng are extracted with water, concentrated, and dried to obtain Panax notoginseng stem and leaf extract; Schisandra chinensis is crushed, extracted with water, concentrated, and dried to obtain Schisandra chinensis water extract; Rhodiola rosea is washed, sliced, dried, and pulverized to obtain Rhodiola rosea root powder; Drynaria fortunei is enzymatically hydrolyzed, filtered, concentrated, and dried to obtain Drynaria fortunei enzymatic hydrolysate; Dipsacus asperoides is washed, sliced, dried, and pulverized to obtain Dipsacus asperoides dried powder; Polygonatum sibiricum is washed, sliced, high-pressure steamed, dried, and pulverized to obtain Polygonatum sibiricum high-pressure steamed powder; Polygonatum odoratum is washed, sliced, dried, and pulverized to obtain Polygonatum odoratum dried powder; Glycyrrhiza uralensis is dried and pulverized to obtain Glycyrrhiza uralensis extract; the above materials are weighed according to the specified weight parts, mixed, and pulverized to obtain the Chinese herbal composition. S2. Weigh the Chinese herbal medicine composition, guanidinoacetic acid, magnesium source, betaine, amino acids, yeast selenium, organic chromium, vitamin E, vitamin C, brewer's yeast extract and appetite stimulant according to the weight proportions, mix them, and then granulate and dry them to obtain the feed additive.

7. The preparation method according to claim 6, characterized in that, In step S1, the honey-processing of the Acanthopanax senticosus-Astragalus membranaceus mixture includes: mixing honey and water at a ratio of 1:(0.4-0.6), heating to 116-118℃ for refining, diluting by 1:1, soaking for 1.5-2.5 hours, and frying at 105-115℃.

8. The preparation method according to claim 6, characterized in that, In step S1, the enzymatic hydrolysis for preparing the *Drynaria fortunei* hydrolysate includes: adding papain and cellulase, hydrolyzing at 50°C for 4 hours, and inactivating the enzyme at 85°C for 15 minutes.

9. The preparation method according to claim 6, characterized in that, In step S1, the high-pressure steaming process for preparing the Polygonatum high-pressure steamed powder includes: steaming at 0.15-0.2 MPa and 110-120℃ for 1-2 hours.

10. The preparation method according to claim 6, characterized in that, In step S2, the conditioning temperature for granulation drying is 55-65℃.

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