A device for simultaneous detection of multiple pathogenic nucleic acids

Abstract

The application relates to the technical field of pathogen detection devices, and discloses a device for synchronously detecting multiple pathogenic nucleic acids, which comprises a base, a top cover, a detachable connecting assembly arranged between the base and the top cover, a preparation box arranged in the base, a folding mechanism arranged in the preparation box, a plurality of clamping grooves formed in the inner wall of the preparation box, and long clamping grooves and short clamping grooves. The preparation box and the folding mechanism are deformable, the clamping grooves are formed in the inner wall of the preparation box, the outer thick plate and the center thin plate of the folding mechanism are slidably connected with the clamping blocks and the clamping grooves, the folding mechanism can be converted among multiple states such as folding and unfolding, the space is saved in the folding state, and the device is convenient to carry; when unfolded, the test tube clamping assembly can firmly clamp the test tube, the unfolded test tube clamping assembly forms a parallelogram clamping groove, and the parallelogram clamping groove is combined to form a compressed flat plate, so that the device has good stability and is convenient to store.

Description

Technical Field

[0001] This invention relates to the field of pathogen detection device technology, and in particular to a device for simultaneous detection of nucleic acids of multiple pathogens. Background Technology

[0002] In practical field operations for nucleic acid detection of pathogens such as livestock, poultry, and infectious diseases, numerous inconveniences exist. Currently, multi-pathogen nucleic acid simultaneous detection equipment lacks flexibility for field use. The devices are bulky and difficult to carry, increasing the difficulty of transportation to the testing site. The operation procedures are cumbersome, requiring significant manpower and time, and demanding high levels of expertise from operators. Furthermore, the design for test tube placement is inadequate, making it difficult to efficiently and stably secure test tubes of different sizes, leading to situations such as tipping and collisions. Sample retention is also extremely inconvenient; improper sample preservation can affect the accuracy and reliability of test results. Therefore, it is essential to develop a detection device that is more convenient for field operation and effectively solves the problems of test tube placement and sample retention.

[0003] Patent CN222007794U discloses an animal pathogen nucleic acid detection device. The device body includes a base and a reaction tube. The base is connected to an electric telescopic rod, which is connected to a crossbar. The crossbar is connected to a cylinder and a first support rod. The bottom of the cylinder is connected to a ring, and a test tube is placed on the ring. The first support rod has a pillar, a bearing, a shaft, and a second support rod. The second support rod is connected to a third support rod through a slide. The slide has a pulley, and a round shaft, a support plate, a spring, and a funnel are arranged between the slides. The third support rod is threaded to a threaded rod, which is threaded to a hollow column. The hollow column is connected to a fourth support rod. A short rod is placed inside the reaction tube, and a needle is placed in the middle of the short rod. The base of this patent has a receiving box. The top of the reaction tube has a thread that can be locked to the cylinder thread. The electric telescopic rod can adjust the height of the device. The needle can puncture the plastic film at the bottom of the test tube for direct detection after collection. The slide can rotate, and the funnel can slide and rise. The test tube has a sealing cap.

[0004] The existing technology has the following drawbacks: Inconvenient placement of test tubes and samples: Existing testing equipment does not have a reasonable placement structure designed for test tubes and samples. The complex on-site environment and limited space increase the difficulty of orderly placement. During testing, test tubes are placed haphazardly, are easily tipped over, and are difficult to retrieve. There is no dedicated and standardized area for samples, which can easily be confused with other objects, leading to serious consequences. Tipping of test tubes can cause sample leakage and cross-contamination, affecting the accuracy of testing. Improper placement of samples can result in loss or damage, failing to meet the needs of re-examination and traceability, and seriously interfering with the normal progress of testing work.

[0005] The lack of an operating platform leads to insufficient operating space: Most existing testing devices are testing boxes, lacking a usable operating platform. This forces operators to work in a limited space, restricting their actions. Operations requiring more space, such as sample mixing and instrument connection, are difficult to complete. Insufficient operating space severely reduces testing efficiency, significantly increases the risk of operational errors, and results in inaccurate test results. Moreover, it greatly increases the workload and fatigue of operators, making it difficult to advance on-site testing and complete testing tasks efficiently and accurately. Summary of the Invention

[0006] In view of the problems of inconvenient placement of test tubes and samples and insufficient operating space due to the lack of an operating platform in the existing technology, a device for simultaneous detection of nucleic acids of multiple pathogens is proposed.

[0007] This application provides a device for simultaneous detection of nucleic acids of multiple pathogens. Its purpose is to: use a detachable detection box that can be flexibly combined and disassembled on site to form an operation platform, solving the problems of insufficient operation platform and operation space in existing detection devices, improving detection efficiency, reducing the risk of operational errors, and the deformable preparation box can efficiently and stably fix test tubes. At the same time, after deformation, it forms a special area for storing samples, avoiding test tube tipping, sample confusion and loss, ensuring detection accuracy, and meeting the needs of re-examination and traceability.

[0008] The technical solution of the present invention is as follows: a device for simultaneous detection of nucleic acids of multiple pathogens, including a base and a top cover, and a detachable connecting component disposed between the base and the top cover, and a preparation box disposed inside the base, wherein the preparation box is provided with a folding mechanism inside, and the inner wall of the preparation box is provided with multiple slots, the slots being divided into long slots and short slots; When the folding mechanism is in the folded state, it is placed at the bottom of the preparation box through multiple long slots. When the folding mechanism is flipped out of the folded state and placed inside the preparation box through multiple short slots, it forms a sandwich cavity with the bottom of the preparation box. When the folding mechanism is in the unfolded state and placed inside the preparation box through multiple long slots, it is used to clamp the test tubes. The folding mechanism includes two outer thick plates, and multiple central thin plates are alternately staggered between the two outer thick plates. Each of the multiple central thin plates has a limit block connected to one side. The outer walls of the two outer thick plates and the multiple central thin plates are fixedly connected with locking blocks. The multiple locking blocks are slidably connected to multiple locking slots. Multiple test tube clamping components are provided between the outer thick plates and adjacent central thin plates, and between two adjacent central thin plates.

[0009] The above scheme uses a folding mechanism, with an outer thick plate and a central thin plate forming the main body. The locking block and the locking slot are slidably connected, allowing the folding mechanism to switch between different states. The limiting block restricts the degree of unfolding of the test tube clamping component to avoid excessive displacement. The folded state saves space, and the sandwich cavity formed after flipping can hold isolated samples. When unfolded, it can firmly clamp the test tube. These structures work together to ensure the stability of the detection process, improve the accuracy of the detection results and the flexibility of the device.

[0010] Furthermore, the test tube clamping assembly includes two upper fixing plates and two lower fixing plates. On the same side, the upper fixing plate and the lower fixing plate are fixedly connected to an external thick plate or a central thin plate. Two connecting movable plates are rotatably connected between the two upper fixing plates and the two lower fixing plates. The inner walls of the two connecting movable plates are provided with tube clamping grooves and merging grooves.

[0011] Furthermore, when the test tube clamping assembly is unfolded, the two upper fixed plates, the two lower fixed plates, and the two connecting movable plates form a parallelogram slot. When the test tube clamping assembly is closed, the connecting shafts of the two connecting movable plates are respectively embedded in the two merging slots to form a compression plate.

[0012] By adopting the above scheme, the test tube clamping assembly forms a parallelogram groove to hold the test tube when unfolded, ensuring the stability of the test tube during testing; when closed, the connecting shaft is embedded in the merging groove to form a compression plate, which is convenient for storage and avoids damage to components. This ensures the stability of the test tube during testing and improves the accuracy of the test results; when not in use, it reduces the space occupied, facilitates the carrying and storage of the device, and extends the service life of the device.

[0013] Furthermore, the inner wall of the preparation box is provided with multiple arc-shaped grooves. When the folding mechanism is folded and placed at the bottom of the preparation box, the preparation material bag is placed inside the preparation box. When the folding mechanism is flipped to form a sandwich cavity, the arc-shaped grooves are used to place the sample tubes. When the folding mechanism is unfolded, the arc-shaped grooves are used to support the test tubes.

[0014] By adopting the above scheme, the arc-shaped grooves enable the rational use of space in different application scenarios, ensuring the orderly storage of preparation materials, the safe preservation of retained samples, and the stability of test tubes during the testing process, thereby improving the efficiency of the testing work and the accuracy of the test results.

[0015] Furthermore, the detachable connection assembly includes a fixed base fixedly connected to the base, and two sleeves fixedly connected to the top cover. The inner wall of the fixed base has two opposing sleeve rods that slide against each other. A connecting spring is fixedly connected between the two sleeve rods. The outer wall of each sleeve rod is connected to a pressing push button. The two pressing push buttons slide against each other on the inner wall of the fixed base. The outer wall of the top cover is equipped with multiple torsion spring support feet.

[0016] Furthermore, when the base is connected to the top cover, the two sleeve rods are located inside the two sleeves respectively. When the top cover is opened, the sleeves rotate outside the sleeve rods, and the opening angle is limited by the fixed seat. When the top cover is disconnected from the base, the top cover is supported by multiple torsion spring support feet.

[0017] By adopting the above solution and using the detachable connection components, the device can be flexibly switched between the two states of carrying and operation. When carried, the device has a compact structure, which is convenient for transportation to the testing site. When operated, it provides ample operating space, which solves the problems of lack of operating platform and insufficient operating space in existing testing devices, and improves the convenience and efficiency of testing work.

[0018] Furthermore, a placement platform is fixedly connected to the inner wall of the top cover. The inner wall of the placement platform is provided with a sliding groove and a limiting groove. A supporting inclined plate is connected to the side of the placement platform near the limiting groove. A transparent material shell is provided on the outer wall of the placement platform.

[0019] Furthermore, the inner wall of the transparent material shell is connected to a sliding rod, the transparent material shell slides on the inner wall of the slide groove via the sliding rod, the transparent material shell is embedded in the limiting groove via the sliding rod and is supported by a supporting inclined plate, and a rubber pull rod is connected to the end of the transparent material shell away from the sliding rod.

[0020] Furthermore, the inner wall of the top cover is provided with a through groove, and a transverse block is slidably connected to the inner wall of the through groove. The transparent material shell passes through the through groove and is placed outside the top cover.

[0021] By adopting the above solution, the transparent data casing and placement platform enable convenient data viewing in different states. When the top cover is closed, the data can be viewed by moving the horizontal block and pulling the rubber rod, preparing for the testing work in advance. After the top cover is opened, the transparent data casing can be adjusted to a suitable position for support, allowing operators to refer to the data at any time during the testing process, improving the efficiency and convenience of the testing work, and solving the problem of inconvenient data viewing during the testing process.

[0022] Furthermore, the inner wall of the top cover is equipped with a control computer and a micropipette, and the inner wall of the base is provided with a storage slot, two instrument placement slots and multiple chip placement slots.

[0023] Using the above scheme, the detection process can be controlled and data processed by the set control computer, and the micropipette is used to accurately transfer samples; the inner wall of the base has a storage slot, two instrument placement slots and multiple chip placement slots, which are used to place miscellaneous items, instruments and chips respectively, making it convenient to store and retrieve items during the detection process.

[0024] The beneficial effects of this invention are: By incorporating a deformable preparation box and folding mechanism, the problem of inconvenient placement of test tubes and samples is effectively solved. The inner wall of the preparation box has slots, and the outer thick plate and central thin plate of the folding mechanism are slidably connected to the slots via locking blocks, allowing for multiple states such as folding and unfolding. In the folded state, it saves space and is easy to carry; when flipped, it forms a sandwich cavity for placing isolated samples; when unfolded, the test tube clamping components between multiple central thin plates firmly hold the test tubes, and the unfolded parallelogram slots and combined compression plates provide excellent stability and facilitate storage. Simultaneously, the arc-shaped grooves on the inner wall of the preparation box allow for the separate placement of preparation material bags, sample tubes, and support tubes in different states, preventing test tube tipping, sample confusion, and loss, ensuring testing accuracy, and meeting the needs of re-examination and traceability.

[0025] The detachable connecting assembly enables flexible construction of the operating platform. The base's fixed seat and the top cover's sleeve cooperate, with the sleeve rod rotating within the sleeve and the opening angle limited by the fixed seat. After the top cover is opened, it provides ample operating space. At the same time, the torsion spring support feet can support it after the top cover is opened. During on-site testing, this connecting assembly allows the device to flexibly switch between a compact carrying state and a spacious operating state, solving the problems of insufficient operating platform and operating space in existing testing devices. This enables operations such as sample mixing and instrument connection to be carried out smoothly, reducing the risk of operational errors, improving testing efficiency, and reducing the workload of operators.

[0026] The structure, including the placement platform and transparent data casing, facilitates data viewing during the testing process. The placement platform features a sliding groove, a limiting groove, and a supporting inclined plate. The transparent data casing slides along the sliding groove via a sliding rod, can be embedded in the limiting groove, and is supported by the supporting inclined plate. When the top cover is closed, the data can be viewed by moving the horizontal block and pulling the rubber rod. When the top cover is open, the transparent data casing can be adjusted to a suitable position. The overall structure ensures that operators can refer to the data at any time, improving the accuracy and convenience of the testing work. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the overall structure of the present invention; Figure 2 This is a schematic diagram of the detachable connection component of the present invention; Figure 3 This is a schematic diagram of the sleeve structure of the present invention; Figure 4 This is a schematic diagram of the top cover in the open state of the present invention; Figure 5 This is a schematic diagram of the rubber tie rod structure of the present invention; Figure 6 For the present invention Figure 5 Enlarged structural diagram of point A in the middle; Figure 7This is a schematic diagram of the structure at the transverse moving block of the present invention; Figure 8 This is a schematic diagram showing the operating platform formed by the base and top cover of the present invention. Figure 9 This is a schematic diagram of the preparation box structure of the present invention; Figure 10 This is a schematic diagram of the folding mechanism of the present invention; Figure 11 This is a schematic diagram of the structure at the central thin plate of the present invention; Figure 12 This is a schematic diagram of the test tube clamping assembly of the present invention in its unfolded and folded states; Figure 13 This is a schematic diagram of the arc-shaped groove structure of the present invention; Figure 14 This is a schematic diagram of the test tube clamping assembly of the present invention unfolded in the preparation box; Figure 15 This is a schematic diagram of the sandwich cavity formation state of the present invention.

[0028] In the picture: 1. Base; 11. Storage slot; 12. Chip placement slot; 13. Instrument placement slot; 2. Top cover; 21. Control computer; 22. Micropipette; 23. Transparent data housing; 231. Rubber pull rod; 232. Slide rod; 24. Placement stage; 241. Slide groove; 242. Limiting groove; 243. Support ramp; 244. Penetration groove; 25. Horizontal movement block; 26. Torsion spring support foot; 3. Detachable connection assembly; 31. Sleeve; 32. 33. Fixed base; 34. Press push button; 35. Sleeve rod; 4. Connecting spring; 4. Preparation box; 41. Preparation material bag; 42. Arc groove; 43. Long slot; 44. Short slot; 5. Folding mechanism; 51. External thick plate; 52. Locking block; 53. Limiting block; 54. Central thin plate; 55. Test tube clamping assembly; 551. Upper fixed plate; 552. Connecting movable plate; 553. Lower fixed plate; 554. Tube clamping groove; 555. Merging groove. Detailed Implementation

[0029] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0030] Reference Figure 1 - Figure 15 A device for simultaneous detection of nucleic acids of multiple pathogens is provided, including a base 1 and a top cover 2, and a detachable connecting component 3 disposed between the base 1 and the top cover 2. It also includes a preparation box 4 disposed inside the base 1. The preparation box 4 is provided with a folding mechanism 5 inside. The inner wall of the preparation box 4 is provided with multiple slots, which are divided into long slots 43 and short slots 44.

[0031] Reference Figure 9 - Figure 15 When the folding mechanism 5 is in the folded state, it is placed at the bottom of the preparation box 4 through multiple long slots 43. When the folding mechanism 5 is flipped from the folded state and placed inside the preparation box 4 through multiple short slots 44, it forms a sandwich cavity with the bottom of the preparation box 4. When the folding mechanism 5 is in the unfolded state and placed inside the preparation box 4 through multiple long slots 43, it is used to clamp test tubes. The folding mechanism 5 includes two external thick plates 51, and multiple central thin plates 54 are alternately staggered between the two external thick plates 51. Each of the multiple central thin plates 54 is connected to a limit block 53 on one side. The outer walls of the two external thick plates 51 and the multiple central thin plates 54 are fixedly connected to a locking block 52. The multiple locking blocks 52 are slidably connected to the multiple slots respectively. Multiple test tube clamping components 55 are provided between the external thick plates 51 and the adjacent central thin plates 54, and between two adjacent central thin plates 54.

[0032] Specifically, the detachable connecting component 3 allows the base 1 and the top cover 2 to be flexibly connected and separated according to actual testing needs, improving the convenience and flexibility of the device; the inner wall of the preparation box 4 has multiple slots, which are divided into long slots 43 and short slots 44, and different types of slots are used in conjunction with different states of the folding mechanism 5; the sandwich cavity can be used to place samples that need to be isolated from other materials, such as sample retention reagents; in the process of pathogen nucleic acid detection, test tubes are commonly used sample containers, and the folding mechanism 5 can firmly clamp the test tubes when unfolded, ensuring the stability of the test tubes during the testing process and avoiding the impact of shaking or displacement on the accuracy of the test results; the limiting block 53 limits the degree of unfolding of the test tube clamping component 55 to prevent excessive displacement or misalignment.

[0033] The main body is composed of an outer thick plate 51 and a central thin plate 54 through the folding mechanism 5. The locking block 52 is slidably connected to the locking slot, allowing the folding mechanism 5 to switch between different states. The limiting block 53 restricts the unfolding degree of the test tube clamping component 55 to avoid excessive displacement. The folded state can save space, and the sandwich cavity formed after flipping can place isolated samples. When unfolded, it can firmly clamp the test tube. These structures work together to ensure the stability of the detection process, improve the accuracy of the detection results and the flexibility of the device.

[0034] Reference Figure 11 - Figure 12The test tube clamping assembly 55 includes two upper fixing plates 551 and two lower fixing plates 553. On the same side, the upper fixing plate 551 and the lower fixing plate 553 are fixedly connected to the outer thick plate 51 or the central thin plate 54. Two connecting movable plates 552 are rotatably connected between the two upper fixing plates 551 and the two lower fixing plates 553. The inner walls of the two connecting movable plates 552 are provided with tube clamping grooves 554 and merging grooves 555. When the test tube clamping assembly 55 is unfolded, the two upper fixing plates 551, the two lower fixing plates 553 and the two connecting movable plates 552 form a parallelogram clamping groove. When the test tube clamping assembly 55 is merged, the connecting shafts of the two connecting movable plates 552 are respectively embedded in the two merging grooves 555 to form a compression plate.

[0035] Specifically, the design shape and size of the tube clamping slot 554 can perfectly fit the test tube, ensuring that the test tube can be stably placed in it during the testing process; while the merging slot 555 is designed to realize the merging function of the test tube clamping component 55; the parallelogram-shaped clamping slot can clamp the test tube to prevent it from shaking or shifting during the testing process, ensuring the smooth progress of the testing work; when the testing work is completed or the test tube clamping component 55 is no longer needed, it can be merged. During the merging process, the connecting shafts of the two connecting movable plates 552 will be precisely embedded into the two merging slots 555 respectively, ultimately forming a compressed flat plate, making the test tube clamping component 55 occupy less space when not in use, making it easier to store and organize, and also preventing the connecting movable plates 552 from being damaged due to shaking during the movement or storage of the device.

[0036] The test tube clamping assembly 55, when unfolded, forms a parallelogram-shaped slot to hold the test tube, ensuring its stability during testing; when closed, the connecting shaft is embedded in the closing groove 555 to form a compression plate, which is convenient for storage and avoids damage to components, thereby ensuring the stability of the test tube during testing and improving the accuracy of the test results; when not in use, it reduces the space occupied, making the device easy to carry and store, and extending the service life of the device.

[0037] Reference Figure 9 - Figure 15 The inner wall of the preparation box 4 is also provided with multiple arc-shaped grooves 42. When the folding mechanism 5 is folded and placed at the bottom of the preparation box 4, the preparation material bag 41 is placed inside the preparation box 4. When the folding mechanism 5 is folded and flipped to form a sandwich cavity, the arc-shaped grooves 42 are used to place the sample tube. When the folding mechanism 5 is unfolded, the arc-shaped grooves 42 are used to support the test tube.

[0038] Specifically, the preparation material bag 41 contains various key materials required for testing, such as reagents and sample collection tools. When the folding mechanism 5 is flipped from its folded state to form a sandwich cavity, the arc-shaped groove 42 can well fit the sample retention tube. Placing the sample retention tube in it can ensure the stability of the tube, prevent sample spillage or interference from external factors, and ensure the quality of the retained sample. Retaining some samples is for the convenience of subsequent review, comparison, or further research. When the folding mechanism 5 is in the unfolded state, it is used to clamp the test tube, providing additional support from the side. This, combined with the clamping action of the folding mechanism 5, further enhances the stability of the test tube and reduces the detection error that may be caused by the shaking of the test tube. During the testing process, the test tube needs to remain stable to ensure the accuracy of the test results.

[0039] The arc-shaped groove 42 enables the rational use of space in different application scenarios, ensuring the orderly storage of preparation materials, the safe preservation of retained samples, and the stability of test tubes during the testing process, thereby improving the efficiency of the testing work and the accuracy of the test results.

[0040] Reference Figure 2 - Figure 8 The detachable connecting assembly 3 includes a fixed base 32 fixedly connected to the base 1 and two sleeves 31 fixedly connected to the top cover 2. Two sleeve rods 34 slide opposite each other on the inner wall of the fixed base 32. A connecting spring 35 is fixedly connected between the two sleeve rods 34. Each of the two sleeve rods 34 has a pressing push button 33 connected to its outer wall. The two pressing push buttons 33 slide opposite each other on the inner wall of the fixed base 32. Multiple torsion spring support feet 26 are installed on the outer wall of the top cover 2. When the base 1 is connected to the top cover 2, the two sleeve rods 34 are located inside the two sleeves 31 respectively. When the top cover 2 is opened, the sleeves 31 rotate outside the sleeve rods 34, and the opening angle is limited by the fixed base 32. When the top cover 2 is disconnected from the base 1, the multiple torsion spring support feet 26 support the top cover 2.

[0041] The detachable connection component 3 enables flexible switching between the device's carrying and operation modes. When carried, the device has a compact structure, making it easy to transport to the testing site. When operated, it provides ample operating space, solving the problems of insufficient operating platform and space in existing testing devices, thus improving the convenience and efficiency of testing work.

[0042] Reference Figure 4 - Figure 8The inner wall of the top cover 2 is fixedly connected to a placement platform 24. The inner wall of the placement platform 24 is provided with a sliding groove 241 and a limiting groove 242. A supporting inclined plate 243 is connected to the side of the placement platform 24 near the limiting groove 242. A transparent material shell 23 is provided on the outer wall of the placement platform 24. A sliding rod 232 is connected to the inner wall of the transparent material shell 23. The transparent material shell 23 slides on the inner wall of the sliding groove 241 through the sliding rod 232. The transparent material shell 23 is embedded in the limiting groove 242 through the sliding rod 232 and is supported by the supporting inclined plate 243. A rubber pull rod 231 is connected to the end of the transparent material shell 23 away from the sliding rod 232. A penetrating groove 244 is provided on the inner wall of the top cover 2. A transverse moving block 25 is slidably connected to the inner wall of the penetrating groove 244. The transparent material shell 23 passes through the penetrating groove 244 and is placed outside the top cover 2.

[0043] Specifically, the slide groove 241 is elongated and smooth, providing a smooth track for the sliding rod 232; the limiting groove 242 is located at a specific position and has precise dimensions and shape, used for precise positioning of the sliding rod 232; the supporting inclined plate 243 is inclined and has a certain strength and stability, providing reliable support for the transparent data shell 23 placed in a specific position; the transparent data shell 23 is made of transparent material, making it convenient for operators to directly observe the data placed inside; the penetrating groove 244 penetrates the inner wall of the top cover 2, and the transparent data shell 23 passes through the penetrating groove 244 and is placed outside the top cover 2, so that even when the top cover 2 is not opened, the operator can open the penetrating groove 244 by moving the transverse block 25, and then easily pull the transparent data shell 23 out of the placement table 24 using the rubber pull rod 231, making it convenient and quick to view the data.

[0044] The transparent data housing 23 and the placement platform 24 enable convenient viewing of data in different states. When the top cover 2 is closed, the data can be viewed by moving the horizontal block 25 and pulling the rubber rod 231, thus preparing for the testing work in advance. When the top cover 2 is open, the transparent data housing 23 can be adjusted to a suitable position for support, making it convenient for operators to refer to the data at any time during the testing process. This improves the efficiency and convenience of the testing work and solves the problem of inconvenient data viewing during the testing process.

[0045] Reference Figure 4 The inner wall of the top cover 2 is equipped with a control computer 21 and a micropipette 22, and the inner wall of the base 1 is provided with a storage slot 11, two instrument placement slots 13 and multiple chip placement slots 12.

[0046] Specifically, the control computer 21 can control the detection process and process data, and the micropipette 22 is used to accurately transfer samples; the inner wall of the base 1 has a storage slot 11, two instrument placement slots 13 and multiple chip placement slots 12, which are used to place miscellaneous items, instruments and chips, respectively, to facilitate the storage and retrieval of items during the detection process.

[0047] Working principle of the invention: Before testing, the base 1 and the top cover 2 are connected by a detachable connecting component 3, forming a suitcase shape for easy transport to the testing site. When the top cover 2 needs to be opened, the sleeve 31 will rotate outside the sleeve rod 34, while the fixed seat 32 will limit its opening angle, facilitating the inspection of the internal instruments. Even if the top cover 2 is not opened, the operator can open the penetration slot 244 by moving the transverse block 25 and use the rubber pull rod 231 to pull the transparent data shell 23 out of the placement table 24 to easily view the data and prepare for the testing work.

[0048] During testing, the base 1 and the top cover 2 can be separated to form an operating platform. By squeezing the two squeezing push buttons 33, the sleeve rod 34 is retracted, thereby disconnecting the connection between the base 1 and the top cover 2. Then, the torsion spring support foot 26 is opened to support the top cover 2. At this time, the unfolded top cover 2 and the base 1 together form an operating platform, which effectively solves the problems of the lack of an operating platform and insufficient operating space in the existing testing device. Afterward, the slide rod 232 is slid in the slide groove 241 and embedded into the limiting groove 242. The transparent material shell 23 is supported by the support inclined plate 243, exposing the placement platform 24, which facilitates subsequent sampling and testing operations.

[0049] The inner wall of the preparation box 4 has a long slot 43 and a short slot 44 for cooperating with the folding mechanism 5. When the folding mechanism 5 is in the folded state, it is placed at the bottom of the preparation box 4 through the long slot 43, and the preparation material bag 41 can be placed inside the preparation box 4 at this time. When the folding mechanism 5 is flipped from the folded state, it is placed inside the preparation box 4 through the short slot 44, forming a sandwich cavity with the bottom of the preparation box 4. The arc-shaped groove 42 can be used to place the sample tube.

[0050] When the folding mechanism 5 is unfolded, it is placed inside the preparation box 4 through the long slot 43 to hold the test tubes. The folding mechanism 5 consists of an outer thick plate 51 and a central thin plate 54. The locking block 52 is slidably connected to the slot. The test tube clamping assembly 55 between the outer thick plate 51 and the adjacent central thin plate 54, and between two adjacent central thin plates 54, can stably clamp the test tubes. When the test tube clamping assembly 55 is unfolded, the upper fixed plate 551, the lower fixed plate 553 and the connecting movable plate 552 form a parallelogram slot. When folded, the connecting shaft of the connecting movable plate 552 is embedded in the folding slot 555 to form a compression plate.

[0051] The inner wall of the top cover 2 is also equipped with a control computer 21 and a micropipette 22. The control computer 21 can control the detection process and process data, and the micropipette 22 is used to accurately transfer samples. The inner wall of the base 1 is provided with a storage slot 11, two instrument placement slots 13 and multiple chip placement slots 12, which are used to place miscellaneous items, instruments and chips, respectively, to facilitate the storage and retrieval of items during the detection process.

[0052] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A device for simultaneous detection of nucleic acids of multiple pathogens, comprising a base (1) and a top cover (2), and a detachable connecting assembly (3) disposed between the base (1) and the top cover (2), characterized in that: It also includes a preparation box (4) set inside the base (1), the preparation box (4) is provided with a folding mechanism (5), and the inner wall of the preparation box (4) is provided with multiple slots, the slots being divided into long slots (43) and short slots (44). When the folding mechanism (5) is in the folded state, it is placed at the bottom of the preparation box (4) through multiple long slots (43). When the folding mechanism (5) is flipped from the folded state and placed inside the preparation box (4) through multiple short slots (44), it forms a sandwich cavity with the bottom of the preparation box (4). When the folding mechanism (5) is in the unfolded state and placed inside the preparation box (4) through multiple long slots (43), it is used to hold test tubes. The folding mechanism (5) includes two external thick plates (51), and multiple central thin plates (54) are alternately staggered between the two external thick plates (51). Each of the multiple central thin plates (54) is connected to a limit stop (53) on one side. Each of the two external thick plates (51) and the multiple central thin plates (54) is fixedly connected to a locking block (52). Each of the multiple locking blocks (52) is slidably connected to multiple locking slots. Multiple test tube clamping components (55) are provided between the external thick plates (51) and the adjacent central thin plates (54), and between two adjacent central thin plates (54).

2. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 1, characterized in that: The test tube clamping assembly (55) includes two upper fixing plates (551) and two lower fixing plates (553). On the same side, the upper fixing plate (551) and the lower fixing plate (553) are fixedly connected to the outer thick plate (51) or the central thin plate (54). Two connecting movable plates (552) are rotatably connected between the two upper fixing plates (551) and the two lower fixing plates (553). The inner walls of the two connecting movable plates (552) are provided with tube clamping grooves (554) and merging grooves (555).

3. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 2, characterized in that: When the test tube clamping assembly (55) is unfolded, the two upper fixing plates (551), the two lower fixing plates (553) and the two connecting movable plates (552) form a parallelogram slot. When the test tube clamping assembly (55) is closed, the connecting shafts of the two connecting movable plates (552) are respectively embedded in the two merging slots (555) to form a compression plate.

4. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 1, characterized in that: The inner wall of the preparation box (4) is also provided with multiple arc-shaped grooves (42). When the folding mechanism (5) is folded and placed at the bottom of the preparation box (4), the preparation material bag (41) is placed inside the preparation box (4). When the folding mechanism (5) is folded and flipped to form a sandwich cavity, the arc-shaped grooves (42) are used to place the sample tube. When the folding mechanism (5) is unfolded, the arc-shaped grooves (42) are used to support the test tube.

5. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 1, characterized in that: The detachable connection assembly (3) includes a fixed seat (32) fixedly connected to the base (1) and two sleeves (31) fixedly connected to the top cover (2). The inner wall of the fixed seat (32) has two opposing sleeve rods (34), and a connecting spring (35) is fixedly connected between the two sleeve rods (34). The outer walls of the two sleeve rods (34) are connected to a pressing push button (33), and the two pressing push buttons (33) slide opposite each other on the inner wall of the fixed seat (32). The outer wall of the top cover (2) is equipped with multiple torsion spring support feet (26).

6. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 5, characterized in that: When the base (1) is connected to the top cover (2), the two sleeve rods (34) are located inside the two sleeves (31) respectively. When the top cover (2) is opened, it rotates outside the sleeve rods (34) through the sleeves (31) and the opening angle is limited by the fixed seat (32). When the top cover (2) is disconnected from the base (1), the top cover (2) is supported by multiple torsion spring support feet (26).

7. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 1, characterized in that: The inner wall of the top cover (2) is fixedly connected to a placement platform (24). The inner wall of the placement platform (24) is provided with a sliding groove (241) and a limiting groove (242). A supporting inclined plate (243) is connected to the side of the placement platform (24) near the limiting groove (242). A transparent material shell (23) is provided on the outer wall of the placement platform (24).

8. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 7, characterized in that: The inner wall of the transparent material shell (23) is connected to a slide rod (232). The transparent material shell (23) slides on the inner wall of the slide groove (241) via the slide rod (232). The transparent material shell (23) is embedded in the limiting groove (242) via the slide rod (232) and is supported by a support inclined plate (243). A rubber pull rod (231) is connected to one end of the transparent material shell (23) away from the slide rod (232).

9. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 8, characterized in that: The inner wall of the top cover (2) is provided with a through groove (244), and a transverse block (25) is slidably connected to the inner wall of the through groove (244). The transparent material shell (23) passes through the through groove (244) and is placed outside the top cover (2).

10. The device for simultaneous detection of nucleic acids of multiple pathogens according to claim 1, characterized in that: The inner wall of the top cover (2) is equipped with a control computer (21) and a micropipette (22), and the inner wall of the base (1) is provided with a storage slot (11), two instrument placement slots (13) and multiple chip placement slots (12).

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