Sample analyzer and cleaning device

Abstract

The embodiment of the present application provides a sample analyzer and a cleaning device. The cleaning device comprises a cleaning component, the cleaning component forms a containing groove, and the containing groove is provided with a first cleaning pool and a second cleaning pool; wherein the first cleaning pool forms a first cleaning cavity with a first opening and a first liquid inlet, the first opening is arranged at the top of the first cleaning pool, and the first liquid inlet is arranged at the side wall or the bottom of the first cleaning pool; the second cleaning pool forms a second cleaning cavity with a second opening, the second opening is arranged at the top of the second cleaning pool, and the side wall and the bottom of the second cleaning pool are in a closed structure; the containing groove is provided with a first liquid outlet, liquid overflowing from the first cleaning pool and the second cleaning pool can be discharged through the first liquid outlet; and a filter screen component at least partially covers the first liquid outlet, and / or the filter screen component is arranged on a liquid flow channel between the first opening and the second opening and the first liquid outlet.

Description

Technical Field

[0001] This application relates to the field of medical device technology, and in particular to a sample analyzer and cleaning device. Background Technology

[0002] In sample analyzers, sample transfer is usually carried out using a sample dispensing needle. Therefore, in order to prevent the surface of the sample dispensing needle from carrying contaminants, it is necessary to clean the sample dispensing needle. Among these cleaning methods, cleaning the outer wall of the sample dispensing needle is an important part of the sample dispensing needle cleaning process.

[0003] In related technologies, the external wall cleaning method typically involves transferring the sampling needle to a cleaning tank and then using a cleaning solution to clean the outer wall of the needle. However, due to the differences in the liquids to be transferred, different liquids have varying effects on the cleaning of the external wall of the sampling needle. Taking blood samples as an example, in some usage scenarios, the samples contain impurities such as fibrin, separating gel, or mixing beads. These impurities are usually highly adhesive or large in size. After the sample transfer is completed, conventional external wall cleaning methods are not suitable. For example, because the impurities are usually highly adhesive, conventional external wall cleaning methods may result in incomplete cleaning of the outer wall of the sampling needle, or the large size of the impurities may cause clogging of the cleaning components. Summary of the Invention

[0004] The main objective of this application is to provide a sample analyzer and a cleaning device, which aims to improve the cleaning effect of the sample dispensing needle and reduce the risk of clogging of the cleaning device.

[0005] In a first aspect, embodiments of this application provide a sample analyzer, comprising:

[0006] A sample dispensing device includes a dispensing needle and a needle moving mechanism. The dispensing needle is used to aspirate a sample and add the sample to a reaction container, and the needle moving mechanism is used to drive the dispensing needle to move.

[0007] A cleaning device includes a cleaning component, a liquid supply component, and a filter component. The cleaning component forms a receiving tank, and the receiving tank contains a first cleaning pool and a second cleaning pool. The first cleaning pool forms a first cleaning chamber with a first opening and a first liquid inlet, the first opening being located at the top of the first cleaning pool and the first liquid inlet being located at the side wall or bottom of the first cleaning pool. The second cleaning pool forms a second cleaning chamber with a second opening, the second opening being located at the top of the second cleaning pool, and the side wall and bottom of the second cleaning pool are closed structures. The receiving tank is provided with a first drain outlet, through which liquid overflowing from the first and second cleaning pools can be discharged. The filter component is disposed in the liquid flow path between the first and second openings and the first drain outlet, and at least partially covers the first drain outlet. The liquid supply component is used to supply a first cleaning solution to the first cleaning pool through the first liquid inlet and to supply a second cleaning solution to the sampling needle.

[0008] The control device, wherein the sample analyzer is provided with a first cleaning mode and a second cleaning mode, is used for:

[0009] Before the sample aspiration operation is performed on the sample, the sample analyzer is controlled to clean the sample aspiration needle using the first cleaning mode;

[0010] After the sample aspiration operation is performed on the sample dispensing needle, and it is determined that there are adhering substances on the outer wall and / or tip of the dispensing needle, the sample analyzer is controlled to use the second cleaning mode to clean the dispensing needle, and the sample dispensing needle is controlled to discharge the sample inside the needle.

[0011] In the first cleaning mode, the needle moving mechanism is controlled to drive the sampling needle to move sequentially to the second cleaning tank, the first cleaning tank and the second cleaning tank, and the cleaning device is controlled to clean the sampling needles located in the corresponding cleaning tanks sequentially.

[0012] In the second cleaning mode, the needle moving mechanism is controlled to drive the sampling needle to the first cleaning tank and the cleaning device is controlled to clean the sampling needle located in the first cleaning tank; after the sampling needle in the first cleaning tank is cleaned, the needle moving mechanism is controlled to drive the sampling needle to the second cleaning tank and the cleaning device is controlled to clean the sampling needle located in the second cleaning tank.

[0013] As can be seen from the above implementation scheme, this embodiment sets two different cleaning modes. Before the sample is drawn by the needle, the inner and outer walls of the needle are cleaned by the first cleaning mode. After the sample is drawn by the needle, and if there are any deposits on the outer wall and / or tip of the needle, the second cleaning mode is used to clean the needle so as to effectively remove the deposits (such as mixing beads, fibrin or separating gel) on the outer wall and / or tip of the needle.

[0014] Furthermore, the cleaning device is equipped with a filter screen component, which filters out the deposits washed off from the sampling needle, preventing the sampling needle from clogging the drain port or drain channel of the cleaning device with deposits such as mixing beads, fibrin, or separating gel.

[0015] Secondly, embodiments of this application also provide a cleaning apparatus, which can be applied to a sample analyzer, including:

[0016] A cleaning component forms a receiving tank, and the receiving tank is provided with a first cleaning pool and a second cleaning pool; wherein, the first cleaning pool forms a first cleaning chamber having a first opening and a first liquid inlet, the first opening being located at the top of the first cleaning pool, and the first liquid inlet being located at the side wall or bottom of the first cleaning pool; the second cleaning pool forms a second cleaning chamber having a second opening, the second opening being located at the top of the second cleaning pool, and the side wall and bottom of the second cleaning pool being a closed structure; the receiving tank is provided with a first drain outlet, through which liquid overflowing from the first cleaning pool and the second cleaning pool can be discharged; and

[0017] A filter element at least partially covers the first drain port, and / or the filter element is disposed in the liquid flow path between the first opening and the second opening to the first drain port.

[0018] In this embodiment, the cleaning device is equipped with a filter screen component to filter out the deposits washed off from the sampling needle, preventing the sampling needle from clogging the drain port or drain channel of the cleaning device with deposits such as mixing beads, fibrin, or separating gel.

[0019] It should be understood that the above general description and the following detailed description are exemplary and explanatory only, and do not limit the disclosure of the embodiments of this application. Attached Figure Description

[0020] To more clearly illustrate the technical solutions of the embodiments of this application, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 A schematic structural block diagram of a sample analyzer provided in an embodiment of this application;

[0022] Figure 2 This is a schematic diagram of the sample analyzer in one embodiment;

[0023] Figure 3 This is a schematic diagram of the dispensing device of a sample analyzer in one embodiment;

[0024] Figure 4 This is a schematic structural block diagram of the cleaning device for a sample analyzer in one embodiment;

[0025] Figure 5 This is a three-dimensional structural diagram of the cleaning device of a sample analyzer in one embodiment;

[0026] Figure 6 This is a three-dimensional structural diagram of the cleaning device for the sample analyzer in another embodiment;

[0027] Figure 7 This is a schematic diagram of the structure of a sample analyzer cleaning device with a filter screen component installed in one embodiment;

[0028] Figure 8 This is a schematic diagram illustrating a scenario where the sampling needle is cleaned in the first cleaning mode of a sample analyzer according to one embodiment.

[0029] Figure 9 This is a schematic diagram illustrating a scenario where the sampling needle is cleaned in the second cleaning mode of a sample analyzer according to one embodiment.

[0030] Figure 10 This is a schematic diagram illustrating a scenario in which the sample analyzer performs corresponding actions during the sampling action cycle, as described in one embodiment. Detailed Implementation

[0031] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0032] In the description of this application, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.

[0033] The flowchart shown in the attached diagram is for illustrative purposes only and does not necessarily include all content and operations / steps, nor does it necessarily have to be performed in the order described. For example, some operations / steps can be broken down, combined, or partially merged, so the actual execution order may change depending on the actual situation.

[0034] The following detailed description of some embodiments of this application is provided in conjunction with the accompanying drawings. Unless otherwise specified, the following embodiments and features can be combined with each other.

[0035] Please refer to Figure 1 This application provides a sample analyzer 100 for analyzing a sample to be tested in order to obtain corresponding analysis results.

[0036] In some implementations, the sample analyzer 100 includes, but is not limited to, at least one of the following: a biochemical analyzer, an immunoassay analyzer, a coagulation analyzer, and a urine analyzer.

[0037] like Figure 1 As shown, the sample analyzer 100 includes a dispensing device 10, a sample device 20, a reagent device 30, a reaction device 40, a measuring device 50, and a control device (also called a controller) 70.

[0038] The sample device 20 is used to provide samples, and the reagent device 30 is used to provide reagents that react with the samples. For example, the reagent device 30 is provided with multiple reagent placement positions, which are used to hold reagent containers. The reagents that react with the samples are stored in the reagent containers. The reagents include, but are not limited to, chromogenic reagents, diluents, substrate solutions, enzyme-labeled reagents, magnetic bead reagents, etc.

[0039] The dispensing device 10 is used to perform sample and / or reagent dispensing operations to dispense samples and / or reagents into a target container. For example, the dispensing device 10 can be used to draw samples from sample tubes supplied by the sample device 20 and transfer the samples to the target container, and discharge the drawn samples into the target container, thereby completing the sample dispensing.

[0040] The reaction apparatus 40 is provided with at least one reaction position for placing a reaction container. This reaction container is used to receive samples and reagents and to provide a mixing space for the samples and reagents. The reaction container includes, but is not limited to, a reaction cup. For example, the sample analyzer 100 is provided with a sample aspiration position and a reagent aspiration position. During the sample and reagent mixing process, the dispensing device 10 aspirates the sample supplied by the sample device 20 and the reagent supplied by the reagent device 30, respectively, and dispenses the aspirated sample and reagent into the reaction container placed in the preset operating position, so that the sample and reagent mix within the reaction container to form a reaction solution. Optionally, the reaction apparatus 40 is also used to incubate the reaction solution formed by the mixture of samples and reagents.

[0041] The measuring device 50 is used to detect and analyze the reaction solution formed by mixing the sample and reagents to obtain detection data. For example, the measuring device 50 is used to measure the reaction solution in the reaction vessel to obtain the sample's detection data.

[0042] Optionally, the measuring device 50 includes a photometric mechanism for detecting the luminescence intensity of the reaction liquid to obtain the luminescence intensity of the reaction liquid. Then, using a calibration curve and the luminescence intensity, the concentration of the analyte in the sample can be calculated. It is understood that the detection data acquired by the measuring device 50 can be either the luminescence intensity of the reaction liquid or the concentration of the analyte in the reaction liquid. That is, calculating the concentration of the analyte in the sample using a calibration curve and the luminescence intensity can be performed by the measuring device 50 or the control device 70; no limitation is made here. Optionally, the measuring device 50 is separately disposed around the reaction device 40.

[0043] In another embodiment, the measuring device 50 includes an electrical detection mechanism (e.g., an impedance measuring mechanism) or a detection mechanism based on other principles (e.g., an imaging measuring mechanism).

[0044] Skilled technicians should understand that Figure 1 This is merely an example of a sample analyzer 100 and does not constitute a limitation on the sample analyzer 100. The sample analyzer 100 may include components such as... Figure 1 The sample analyzer 100 may include more or fewer components, or combinations of certain components, or different components. It may also include input / output devices, network access devices, etc.

[0045] The sample analyzer 100 also includes a scheduling device (not shown), which is used to schedule the reaction vessel. Specifically, the scheduling device is used to move the target object in two-dimensional or three-dimensional space to achieve the scheduling of the target object. For example, the scheduling device grabs the target object and moves it in two-dimensional or three-dimensional space, or after the target object is placed in the scheduling position set on the scheduling device, the scheduling device moves the target object placed in the scheduling position in two-dimensional or three-dimensional space.

[0046] For example, the scheduling device schedules the reaction container to the sample position within the sample analyzer 100 so that the dispensing device 10 performs a sample dispensing operation on the reaction container placed at the sample position; or, the scheduling device schedules the reaction container to the reagent position within the sample analyzer 100 so that the dispensing device 10 performs a reagent dispensing operation on the reaction container placed at the reagent position.

[0047] Please see Figure 2 In some embodiments, the reaction apparatus 40 has a support portion 401, and the support portion 401 is provided with at least one reaction position for placing a reaction container (such as a reaction cup 4011). The reaction container is used to receive samples and reagents and to provide a reaction site for the samples and reagents to mix and form a reaction solution. For example, the reaction container receives a sample obtained by the dispensing device 10 from the sample device 20 and a reagent obtained by the reagent device 30, so that the samples and reagents are mixed in the reaction container to form a reaction solution.

[0048] Optionally, the support portion 401 of the reaction apparatus 40 can be a reaction disk, such as... Figure 2 As shown, it is arranged in a disc-shaped component and has one or more reaction positions for placing reaction containers. The reaction disc can incubate the reaction liquid in the reaction container and can rotate to drive the reaction container placed in the reaction position to rotate, so as to realize the scheduling of the reaction container in the reaction disc in a preset area, for example, to schedule the reaction container located in the reaction position to the position for reagent addition.

[0049] It is understood that the reaction position used to support the reaction vessel can be located not only on the reaction plate of the reaction apparatus 40, but also independently of the reaction plate of the reaction apparatus 40. Setting the reaction position independently of the reaction plate means that the setting of the reaction position will not interfere with the rotation of the reaction plate itself.

[0050] Please see Figure 2 In some embodiments, the sample device 20 may include a sample delivery module (SDM) and a front-end track; the sample is placed in the sample tube, and the sample rack carrying one or more sample tubes is dispatched to the corresponding injection position via the front-end track, and the sample delivery module transfers the sample rack located at the injection position to a preset position (such as the aspiration position).

[0051] In other examples, the sample device 20 may also be a sample tray, which includes multiple sample positions for placing sample tubes. By rotating its tray assembly, the sample can be moved to the appropriate position, such as to the aspiration position of the dispensing device 10. The dispensing device 10 is used to aspirate the sample and dispense it into the reaction vessel to be added.

[0052] In some embodiments, the dispensing device 10 is used to perform sample and / or reagent dispensing operations to dispense samples and / or reagents into a target container. For example, the dispensing device 10 receives a sample supplied by the sample aspiration device 20 and transfers the sample to the reaction container to be added, or the dispensing device 10 receives a reagent supplied by the reagent aspiration device 30 and transfers the reagent to the reaction container to be added.

[0053] like Figure 2 As shown, in some embodiments, the reagent device 30 is used to provide reagents that react with the sample. The reagent device 30 is provided with a plurality of reagent positions 301b. The reagent placement positions are used to hold reagent containers. The reagents that react with the sample are stored in the reagent containers. The reagents include, but are not limited to, chromogenic reagents, diluents, substrate solutions, enzyme-labeled reagents, magnetic bead reagents, etc.

[0054] In some embodiments, the reagent device 30 can be a disc-shaped structure or a linear structure. Taking a disc-shaped reagent device 30 as an example, for ease of explanation, this reagent device 30 will be referred to as a reagent disc 301. The reagent disc 301 is arranged in a disc shape and has multiple reagent positions 301b, which can rotate and drive the reagents carried in the reagent positions 301b to rotate. By rotating the reagent disc 301, the reagents can be transferred to the reagent aspiration positions for the dispensing component of the measuring device 50 to aspirate the reagents. The reagent disc 301 may have an openable and closable reagent disc cover, allowing the user to place reagents into or remove reagents from the reagent disc 301 when the cover is opened.

[0055] Optionally, the reagent tray 301 may include at least one rotatable reagent track 301a, the reagent track 301a being provided with a plurality of reagent positions 301b for carrying reagents, the reagent track 301a rotating to move the reagent containers on its reagent positions 301b.

[0056] Optionally, the reagent tray 301 includes multiple reagent tracks 301a, each capable of independent rotation. The reagent tracks 301a rotate and move the reagent containers they carry, thereby rotating the containers to the reagent aspiration position for the dispensing component of the measuring device 50 to draw up the reagents.

[0057] Please see Figure 3 In some embodiments, the dispensing device 10 includes a sample dispensing device 10a, wherein the sample dispensing device 10a is used to aspirate the sample supplied by the sample device 20 and transfer the sample to a preset position. For example, the sample device 20 carries a sample tube containing the sample to be tested, and the sample dispensing device 10a aspirates the sample to be tested from the sample tube carried by the sample device 20 and discharges the sample into the reaction container to be dispensed.

[0058] Optionally, the sample application device 10a includes a sample application needle 101 and a first needle moving mechanism 102, which supports the sample application needle 101 and drives it to move. For example, the sample application needle 101 can move in two or three dimensions in space through the two-dimensional or three-dimensional first needle moving mechanism 102, so that the sample application needle 101 can move to pick up the sample carried by the sample application device 20.

[0059] Optionally, the sample application device 10a further includes a first power mechanism 103, which provides power for the sample application needle 101 to perform sample aspiration and / or dissipation, thereby completing the sample aspiration and / or dissipation. For example, taking the sample application needle 101 performing sample aspiration as an example, the sample application needle 101 moves under the drive of the first needle moving mechanism 102 to the sample tube containing the sample to be tested on the sample device 20, and aspirates the sample to be tested under the drive of the first power mechanism 103, and delivers the sample to be tested to the reaction container located in the reaction position of the reaction device 40, so that the sample to be tested aspirated by the sample application device 10a is mixed with the reagent provided by the reagent device 30 in the reaction container.

[0060] like Figure 3 As shown, in some embodiments, the first needle moving mechanism 102 includes a support frame 1021, which is fixed to a support rod 1022. The support rod 1022 is vertically movable and rotatable, and the support frame 1021 moves vertically and rotates horizontally under the drive of the support rod 1022. The sample dispensing needle 101 is mounted on the support frame 1021 and can reach the target position under the drive of the support frame 1021. Exemplarily, the first needle moving mechanism 102 also includes a driver 1023 for driving the support rod 1022 to move, such as a stepper motor, but is not limited to this. Optionally, the sample dispensing needle 101 is detachably connected to the first needle moving mechanism 102 or fixedly connected.

[0061] Optionally, the first power mechanism 103 includes a tubing 1031 and a power assembly 1033. The tubing 1031 is used to transport a fluid medium. One end of the tubing 1031 is connected to the sampling needle 101, and the other end is connected to the power assembly 1033, so that the flow direction of the fluid medium in the tubing 1031 can be changed under the action of the power assembly 1033, so that the sampling needle 101 can transfer samples and / or reagents. The power assembly 1033 includes, but is not limited to, a syringe, a pump, and a valve body disposed on the tubing 1031.

[0062] like Figure 2As shown, in some embodiments, the dispensing device 10 further includes a reagent dispensing mechanism 10b, and the reagent device 30 includes a reagent carrying mechanism 301 for carrying the reagent container. The reagent dispensing mechanism 10b of the dispensing device 10 draws the reagent from the reagent container carried by the reagent device 30 and provides it to the reaction device 40.

[0063] Optionally, the reagent carrying mechanism 301 can be a reagent tray, which is a disc-shaped assembly with multiple positions for carrying reagent containers. The reagent carrying mechanism 301 can rotate and drive the reagent containers it carries to rotate, so as to rotate the reagent containers to a preset position, such as the reagent aspiration position where the reagent is drawn up by the reagent dispensing mechanism 10b. The number of reagent carrying mechanisms 301 can be one or more.

[0064] In some embodiments, the reagent dispensing mechanism 10b may include a reagent needle, a second needle moving mechanism, and a second power mechanism. The reagent needle moves in two or three dimensions in space via the two-dimensional or three-dimensional second needle moving mechanism, thereby allowing the reagent needle to move and cooperate with the second power mechanism to draw the reagent carried by the reagent carrying mechanism 301, and to move to the reaction container to which the reagent is to be added, and to discharge the reagent into the reaction container.

[0065] In some embodiments, the second needle moving mechanism and the first needle moving mechanism 102 have the same structure, and / or the second power mechanism and the first power mechanism 103 have the same structure, which will not be described in detail here.

[0066] In some embodiments, the reagent dispensing mechanism 10b does not add reagents via a reagent needle, but instead adds the reagents from the reagent tube to the reaction vessel through a dedicated tubing. In these embodiments, only the sample dispensing needle 101 is used, without a reagent needle.

[0067] It is understandable that, depending on the different bodily fluids being tested and the specific test items, different methods of adding samples and reagents may be used. For example, both samples and reagents may be added using the sampling needle 101, or samples may be added using the sampling needle 101 and reagents using the reagent needle, or only samples may be added using the sampling needle 101 and reagents may be added using other methods. That is, the sampling device 10a of the dispensing device 10 is used for both sample transfer and reagent transfer; or the sampling device 10a of the dispensing device 10 is used for sample transfer and the reagent dispensing mechanism 10b is used for reagent transfer; or the sampling device 10a of the dispensing device 10 is used for sample transfer, and the reagent is added to the reaction vessel via a dedicated tubing connected to a reagent container. Therefore, the sampling needle 101 and / or the reagent needle are also called pipettes, meaning that a pipette includes at least one of the sampling needle 101 and the reagent needle.

[0068] As described above, the dispensing device 10 includes a pipette (e.g., a sample dispensing needle 101, a reagent needle), a needle movement mechanism (e.g., a first needle movement mechanism, a second needle movement mechanism), and a power mechanism (e.g., a first power mechanism, a second power mechanism). The pipette is used to transfer samples and / or reagents. The needle movement mechanism is used to drive the pipette to move. The power mechanism is used to provide power for the pipette to aspirate and dispense samples and / or reagents.

[0069] like Figure 1 As shown, in some embodiments, the sample analyzer 100 includes a cleaning device 60. The cleaning device 60 is used to provide cleaning fluid to clean the inner and / or outer walls of pipettes (e.g., sample needle 101, reagent needle).

[0070] Please see Figures 4 to 7 In some embodiments, the cleaning device 60 includes a cleaning component 61, a liquid supply component 62, and a filter component 63. The cleaning component 61 forms a receiving tank 610, and the receiving tank 610 is provided with a first cleaning pool 611 and a second cleaning pool 612.

[0071] The first cleaning tank 611 forms a first cleaning chamber 6110 having a first opening 6111 and a first liquid inlet 6112. The first opening 6111 is located at the top of the first cleaning tank 611, and the first liquid inlet 6112 is located on the side wall or bottom of the first cleaning tank 611.

[0072] The second cleaning tank 612 forms a second cleaning cavity 6120 with a second opening 6121. The second opening 6121 is located at the top of the second cleaning tank 612, and the side walls and bottom of the second cleaning tank 612 are closed structures.

[0073] The receiving tank 610 is provided with a first drain port 613, through which liquid overflowing from the first cleaning tank 611 and the second cleaning tank 612 can be discharged from the receiving tank 610.

[0074] The filter element 63 is disposed on the liquid flow path between the first opening 6111 and the second opening 6121 and the first drain port 613, and at least partially covers the first drain port 613, so that the deposits on the sampling needle 101 cleaned in the first cleaning tank 611 and / or the second cleaning tank 612 can be intercepted and filtered by the filter element 63, so as not to block the first drain port 613 or the drain channel connected to the first drain port 613.

[0075] For example, the filter element 63 covers the first drain port 613, or the filter element 63 is disposed inside the first drain port 613, or the filter element 63 is disposed in the liquid flow passage between the first drain port 613 and the first opening 6111, or the filter element 63 is disposed in the liquid flow passage between the first drain port 613 and the second opening 6121, or the filter element 63 is disposed in the liquid flow passage between the first drain port 613 and the second opening 6121 and the liquid flow passage between the first drain port 613 and the first opening 6111.

[0076] It is understood that there are various ways to install the filter element 63 onto the cleaning element 61. For example, the filter element 63 can be connected to the cleaning element 61 through structural engagement, interference fit, pin engagement, etc. Optionally, the filter element 63 includes a support member and a filter screen disposed on the support member, and the filter element 63 can be detachably installed onto the cleaning element 61 through the support member.

[0077] The liquid supply component 62 is used to supply a first cleaning solution to the first cleaning tank 611 through the first inlet 6112, and to supply a second cleaning solution to the sampling needle 101. Exemplarily, the liquid supply component 62 supplies the first cleaning solution to the first cleaning tank 611 through the first inlet 6112, which can clean the sampling needle 101 located within the first cleaning tank 611. The liquid supply component 62 supplies the second cleaning solution to the sampling needle 101 through an injection port provided on the sampling needle 101, which can clean the inner wall of the sampling needle 101. For example, when the sampling needle 101 is located within the first cleaning tank 611 and / or within the second cleaning tank 612, the liquid supply component 62 supplies the second cleaning solution to the sampling needle 101 through the injection port, thereby cleaning the inner wall of the sampling needle 101. Optionally, the diameter of the second opening 6121 is smaller than the diameter of the first opening 6111. If large particles adhere to the outer wall or tip of the sampling needle 101, it cannot directly enter the second cleaning tank 612 through the second opening 6121 for cleaning. The larger diameter of the first opening 6111 facilitates the entry of the sampling needle 101 into the first cleaning chamber 6110 through the first opening 6111, thereby cleaning the inner and outer walls within the first cleaning tank 611. For example, the diameter of the second opening 6121 is D2, and the diameter of the first opening 6111 is D1, where D1 > D2.

[0078] In some embodiments, the receiving tank 610 further forms an overflow pool 614 having a third opening 6141 and a second drain outlet 6142. The third opening 6141 is located at the top of the overflow pool 614, and the second drain outlet 6142 is located on the side wall or bottom of the overflow pool 614. Furthermore, the top of the overflow pool 614 is higher than the top of the first cleaning pool 611 and the top of the second cleaning pool 612, and the top of the receiving tank 610 is higher than the top of the overflow pool 614. Liquid overflowing from the first cleaning pool 611 and the second cleaning pool 612 can enter the overflow pool 614 through the third opening 6141 and exit the receiving tank 610 through the second drain outlet 6142.

[0079] In some embodiments, the cleaning component 61 further includes a tank cover 615 having a cleaning port 6151. The tank cover 615 is used to cover the top opening of the receiving tank 610 formed by the cleaning component 61, and the sampling needle 101 can enter the corresponding first cleaning tank 611 and second cleaning tank 612 through the cleaning port 6151 for cleaning.

[0080] In some embodiments, the sample analyzer 100 further includes a needle detection device 90, which is used to detect whether there are any attached substances on the outer wall of the sample dispensing needle 101 or the tip of the sample dispensing needle 101, and output corresponding detection information so that the control device 70 can determine whether there are any attached substances on the outer wall of the sample dispensing needle 101 or the tip of the sample dispensing needle 101 based on the detection information output by the needle detection device 90.

[0081] For example, the sampling needle 101 usually aspirates at least one of the sample, reagent or reaction solution at a preset aspiration pressure. The needle detection device 90 detects the pressure change of the sampling needle 101 during the aspiration or dissipation process, and if the detected pressure is greater than the threshold, it indicates that the tip of the sampling needle 101 may be blocked, and thus determines that there is deposited material on the tip of the sampling needle 101.

[0082] For example, the needle detection device 90 acquires an image of the sample aspiration needle 101, performs image analysis on the image, and determines whether there are any attached substances on the outer wall or tip of the sample aspiration needle 101 in the acquired image, and outputs the corresponding detection information to the control device 70. Thus, the control device 70 can know whether there are any attached substances on the outer wall or tip of the sample aspiration needle 101 through the detection information output by the needle detection device 90.

[0083] In some embodiments, the sample analyzer 100 is provided with a first cleaning mode and a second cleaning mode. Before the sampling needle 101 performs a sample aspiration operation, the sample analyzer uses the first cleaning mode to clean the sampling needle 101. After the sampling needle 101 performs a sample aspiration operation, and if there are deposits on the outer wall and / or tip of the sampling needle 101, the sample analyzer 100 uses the second cleaning mode to clean the sampling needle, and during the cleaning process, the sample inside the sampling needle 101 is discharged.

[0084] In the first cleaning mode, the sampling needle 101 is cleaned sequentially in the second cleaning tank 612, the first cleaning tank 611, and the second cleaning tank 612. In the second cleaning mode, the sampling needle 101 is first cleaned in the first cleaning tank 611, and after the sampling needle 101 in the first cleaning tank 611 has been cleaned, it is then moved to the second cleaning tank 612 for cleaning.

[0085] Optionally, during the second cleaning process in the cleaning tank 612, the sample inside the dispensing needle 101 is discharged. It is understood that the control device 70 is communicatively connected to the dispensing device 10, sample device 20, reagent device 30, reaction device 40, needle detection device 90, cleaning device 60, and measuring device 50 to control at least one of these devices to perform a preset operation, such as testing the sample to be tested or cleaning the target device.

[0086] In some embodiments, the control device 70 may be one or more, and the control device 70 may be provided in at least one of the dispensing device 10, sample device 20, reagent device 30, reaction device 40, needle detection device 90, cleaning device 60, and measuring device 50, or may be provided independently, without limitation.

[0087] Optionally, the control device 70 includes at least a processor 701, a memory 702, a communication interface (not shown), and an I / O interface (not shown). The processor 701, memory 702, communication interface, and I / O interface communicate via a bus. The processor 701 can be a Central Processing Unit (CPU), but it can also be other general-purpose processors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. The general-purpose processor can be a microprocessor or any conventional processor.

[0088] The memory 702 contains various computer programs, such as the operating system and application programs, for the processor 701 to execute, as well as the data required to execute these programs. During the analysis of the sample under test, any data requiring local storage can be stored in the memory 702. The I / O interface includes, but is not limited to, serial interfaces such as USB, IEEE 1394, or RS-232C; parallel interfaces such as SCSI, IDE, or IEEE 1284; and analog signal interfaces composed of D / A converters and converters. Input components are connected to the I / O interface, allowing users to directly input data to the control device 70. These input components include, but are not limited to, a keyboard, mouse, touchscreen, or control buttons. The display component can communicate with the control device 70 through the I / O interface to provide relevant information prompts. The communication interface can be any known communication protocol. The communication interface communicates with the outside world via a network, and the control device 70 can transmit data with any component connected through this network using a preset communication protocol.

[0089] In some embodiments, the control device 70 is at least used to perform the following operation: the processor 701 of the control device 70 calls the computer program in the memory 702 to perform the following operation: before the sampling needle 101 performs the sample aspiration operation, the sample analyzer 100 is controlled to clean the sampling needle 101 using a first cleaning mode.

[0090] After the sample aspiration operation is performed on the sample by the sampling needle 101, and it is determined that there are attached substances on the outer wall and / or tip of the sampling needle 101, the sample analyzer 100 is controlled to use the second cleaning mode to clean the sampling needle 101, and the sampling needle 101 is controlled to discharge the sample inside the needle.

[0091] In the first cleaning mode, the first needle moving mechanism 102 is controlled to drive the sample needle 101 to move sequentially to the second cleaning pool 612, the first cleaning pool and the second cleaning pool 612, and the cleaning device 60 is controlled to clean the sample needle 101 located in the corresponding cleaning pool sequentially.

[0092] In the second cleaning mode, the first needle moving mechanism 102 is controlled to drive the sampling needle 101 to the first cleaning tank 611 and the cleaning device 60 is controlled to clean the sampling needle 101 located in the first cleaning tank 611. After the sampling needle 101 in the first cleaning tank 611 is cleaned, the needle moving mechanism is controlled to drive the sampling needle 101 to the second cleaning tank 612 and the cleaning device 60 is controlled to clean the sampling needle 101 located in the second cleaning tank 612.

[0093] Please see Figures 8 to 9 Before the sampling needle 101 performs the sample aspiration operation, in order to improve the surface cleanliness of the sampling needle 101, the control device 70 controls the sample analyzer 100 to use the first cleaning mode to clean the sampling needle 101.

[0094] like Figure 8 As shown, in the first cleaning mode, the control device 70 controls the first needle moving mechanism 102 to drive the sampling needle 101 to move to the second cleaning tank 612, and controls the liquid supply component 62 of the cleaning device 60 to supply the second cleaning solution to the injection port of the sampling needle 101, so as to clean the inner wall of the sampling needle 101 through the cleaning solution. At the same time, the second cleaning solution injected into the sampling needle 101 through the injection port can be discharged through the outlet of the tip of the sampling needle 101 and enter the second cleaning chamber 6120 of the second cleaning tank 612 to soak or rinse the sampling needle 101 located in the second cleaning chamber 6120, thereby cleaning the outer wall of the sampling needle 101 in the second cleaning chamber 6120. Further, during the cleaning of the inner and outer walls of the sampling needle 101 in the second cleaning chamber 6120, excess second cleaning solution can overflow from the second opening 6121 into the second cleaning chamber 6120 and be discharged from the first drain port 613 of the receiving tank 610.

[0095] After the cleaning time of the sampling needle 101 in the second cleaning tank 612 reaches the preset time, the control device 70 controls the first needle moving mechanism 102 to drive the sampling needle 101 to move to the first cleaning tank 611, and controls the liquid supply component 62 of the cleaning device 60 to supply the second cleaning fluid to the injection port of the sampling needle 101 to clean the inner wall of the sampling needle 101 in the first cleaning tank 611, and controls the liquid supply component 62 of the cleaning device 60 to supply the first cleaning fluid to the first cleaning tank 611 through the first liquid inlet 6112 to clean the outer wall of the sampling needle 101 in the first cleaning tank 611.

[0096] Furthermore, during the cleaning process of the sampling needle 101 in the first cleaning tank 611, the second cleaning fluid discharged from the sampling needle 101 and the first cleaning fluid entering from the first inlet 6112 can form convection, thereby improving the cleaning effect on the outer wall of the sampling needle 101. Also, during the cleaning of the inner and outer walls of the sampling needle 101 in the first cleaning chamber 6110, excess cleaning fluid can overflow from the first opening 6111 into the first cleaning chamber 6110 and be discharged from the first drain port 613 of the receiving tank 610.

[0097] After the sampling needle 101 has been cleaned in the first cleaning tank 611 for a preset time, the control device 70 controls the first needle moving mechanism 102 to drive the sampling needle 101 to the second cleaning tank 612, and controls the liquid supply component 62 of the cleaning device 60 to supply the second cleaning solution to the injection port of the sampling needle 101, so as to clean the inner wall of the sampling needle 101 through the cleaning solution. At the same time, the second cleaning solution discharged from the outlet of the sampling needle 101 enters the second cleaning chamber 6120 of the second cleaning tank 612 to soak or rinse the sampling needle 101 located in the second cleaning chamber 6120, thereby cleaning the outer wall of the sampling needle 101 in the second cleaning chamber 6120.

[0098] Optionally, the first cleaning solution and the second cleaning solution can be the same cleaning solution or different cleaning solutions. For example, the first cleaning solution includes, but is not limited to, water and cleaning agent, and the second cleaning solution includes, but is not limited to, water, including, but not limited to, deionized water and physiological saline.

[0099] like Figure 9 As shown, after the sampling needle 101 performs a sample aspiration operation, and it is determined that there are adhering substances on the outer wall and / or tip of the sampling needle 101, the control device 70 controls the sample analyzer 100 to use the second cleaning mode to clean the sampling needle 101, and controls the sampling needle 101 to discharge the sample inside the needle.

[0100] The second cleaning mode for cleaning the sampling needle 101 is as follows: the control device 70 controls the first needle moving mechanism 102 to drive the sampling needle 101 to move to the first cleaning pool 611, and controls the liquid supply component 62 of the cleaning device 60 to provide the second cleaning solution to the injection port of the sampling needle 101 to clean the inner wall of the sampling needle 101 in the first cleaning pool 611. The control device 70 also controls the liquid supply component 62 of the cleaning device 60 to provide the first cleaning solution to the first cleaning pool 611 through the first inlet 6112 to clean the outer wall of the sampling needle 101 in the first cleaning pool 611.

[0101] Furthermore, during the cleaning process of the sampling needle 101 in the first cleaning tank 611, the second cleaning liquid discharged from the sampling needle 101 and the first cleaning liquid entering from the first inlet 6112 can form convection, thereby effectively cleaning off the deposits adhering to the outer wall and / or tip of the sampling needle 101, resulting in a better cleaning effect on the outer wall of the sampling needle 101. Simultaneously, during the cleaning of the inner and outer walls of the sampling needle 101 in the first cleaning chamber 6110, the deposits washed off can overflow from the first opening 6111 along with the cleaning liquid and can be intercepted and filtered by the filter screen component 63, thus preventing blockage of the first drain port 613 or the drain channel connected to the first drain port 613.

[0102] After the sampling needle 101 has been cleaned in the first cleaning tank 611 for a preset time, the control device 70 controls the first needle moving mechanism 102 to drive the sampling needle 101 to the second cleaning tank 612, and controls the liquid supply component 62 of the cleaning device 60 to supply the second cleaning solution to the injection port of the sampling needle 101, so as to clean the inner wall of the sampling needle 101 through the cleaning solution. At the same time, the second cleaning solution discharged from the outlet of the sampling needle 101 enters the second cleaning chamber 6120 of the second cleaning tank 612 to soak or rinse the sampling needle 101 located in the second cleaning chamber 6120, thereby cleaning the outer wall of the sampling needle 101 in the second cleaning chamber 6120.

[0103] Since the sample aspiration operation performed by the sampling needle 101 may result in insufficient sample volume if there is any deposit on the outer wall and / or tip of the sampling needle 101 after the operation, it is necessary to control the discharge of sample from the sampling needle 101 in order to ensure accurate quantitative sample aspiration in the next operation. This control can be performed during the cleaning process of the sampling needle 101 using the second cleaning mode, or before the cleaning process using the second cleaning mode.

[0104] For example, before cleaning the sampling needle 101 using the second cleaning mode, the first needle moving mechanism 102 is controlled to drive the sampling needle 101 to a preset discharge position, and the sampling device 10a is controlled to perform a discharge operation to discharge the sample inside the sampling needle 101.

[0105] For example, before cleaning the sample dispensing needle 101 using the second cleaning mode, the first needle moving mechanism 102 is controlled to drive the sample dispensing needle 101 to a preset sample discharge position, and the supply component 62 is controlled to supply the second cleaning solution to the injection port of the sample dispensing needle 101 to discharge the sample inside the sample dispensing needle 101.

[0106] In some embodiments, during the cleaning process of the sampling needle 101 located in the first cleaning tank 611 in the second cleaning mode, the control device 70 is further configured to:

[0107] The liquid supply component 62 supplies the first cleaning solution to the first cleaning tank 611 through the first liquid inlet 6112, and controls the liquid supply component 62 to supply the second cleaning solution to the sample dispensing needle 101 so that the sample dispensing needle 101 can discharge the sample inside the needle.

[0108] like Figure 9 As shown, in the second cleaning mode, during the cleaning process of the sampling needle 101 in the first cleaning tank 611, the control device 70 supplies the second cleaning solution to the sampling needle 101 by controlling the liquid supply component 62, so that the sampling needle 101 discharges the sample inside the needle and uses the second cleaning solution to clean the inner wall of the sampling needle 101. In addition, the control liquid supply component 62 supplies the first cleaning solution to the first cleaning tank 611 through the first liquid inlet 6112, so that the first cleaning solution entering the first cleaning chamber 6120 of the first cleaning tank 611 through the first liquid inlet 6112 and the second cleaning solution discharged from the needle through the sampling needle 101 form a convection, so as to better clean the adhering substances on the outer wall of the sampling needle 101. These adhering substances include, but are not limited to, mixing beads, fibrin, or separating gel.

[0109] In some embodiments, during the cleaning of the sampling needle 101 in the first cleaning tank 611 in the second cleaning mode, the control device 70 is further configured to:

[0110] After the liquid supply component 62 supplies the second cleaning fluid to the sampling needle 101 for a first duration, the liquid supply component 62 is controlled to stop supplying the second cleaning fluid to the sampling needle 101, and the liquid supply component 62 is controlled to continuously supply the first cleaning fluid to the first cleaning tank 611 through the first liquid inlet 6112.

[0111] After the first cleaning fluid has been supplied for a second duration, the control supply component 62 stops supplying the first cleaning fluid to the first cleaning tank 611.

[0112] like Figure 9As shown, in order to maintain the concentration of the first cleaning solution in the first cleaning tank 611 within a certain range so that the sample needle 101 has a better cleaning effect, in the second cleaning mode, during the cleaning of the sample needle 101 in the first cleaning tank 611, the control device 70 controls the liquid supply component 62 to supply the second cleaning solution to the sample needle 101, and controls the liquid supply component 62 to supply the first cleaning solution to the first cleaning tank 611 through the first liquid inlet 6112. After the liquid supply component 62 supplies the second cleaning solution to the sample needle 101 for a first duration, it can be assumed that the sample needle 101 has discharged the sample inside the needle body, and the cleaning of the inner wall of the sample needle 101 has achieved the expected effect. At this time, by controlling the liquid supply component 62 to stop supplying the second cleaning solution to the sampling needle 101, and controlling the liquid supply component 62 to continuously supply the first cleaning solution to the first cleaning tank 611 through the first liquid inlet 6112, the concentration of the first cleaning solution in the first cleaning tank 611 is maintained within a certain range, so as to better achieve the cleaning of the outer wall of the sampling needle 101. After the first cleaning solution is supplied for a second duration, it can be considered that the concentration of the first cleaning solution in the first cleaning tank 611 has been maintained within a certain range, thereby controlling the liquid supply component 62 to stop supplying the first cleaning solution to the first cleaning tank 611.

[0113] In some embodiments, the sampling device 10a further includes a first power mechanism 103, which provides power for the sampling needle 101 to perform sample aspiration and dissipation. In the second cleaning mode, during the cleaning process of the sampling needle 101 located in the first cleaning tank 611, the control device 70 is also used to:

[0114] The control liquid supply component 62 supplies the first cleaning liquid to the first cleaning tank 611 through the first liquid inlet 6112, and controls the first power mechanism to provide power to the sample dispensing needle 101 so that the sample dispensing needle 101 dispenses the sample inside the needle.

[0115] like Figure 9 As shown, the sample inside the needle body of the sampling needle 101 can be discharged from the needle body by supplying a second cleaning solution to the sampling needle 101 through the supply component 62, or by supplying power to the sampling needle 101 through the first power mechanism 103.

[0116] In some embodiments, the control device 70 controls the sampling device to aspirate the sample from the sample container at the sampling position during the sampling operation cycle, and discharges the sample into the reaction container at the discharge position; wherein, the sampling operation cycle includes a sampling sub-cycle and a discharge sub-cycle. During the sampling sub-cycle, the control device 70 controls the sampling needle 101 to aspirate the sample from the sample container at the sampling position; and during the discharge sub-cycle, the control device 70 controls the sampling needle 101 to discharge the sample into the reaction container at the discharge position.

[0117] The control device 70 is also used for:

[0118] During the sampling cycle, the sampling needle 101 is controlled to perform a sampling operation on the sample to aspirate the sample carried by the sample container located at the sampling position, and the presence of any attached substances is detected on the outer wall and / or tip of the sampling needle 101.

[0119] When it is confirmed that there are no adhering substances on the outer wall and / or tip of the dispensing needle 101, the dispensing needle 101 is controlled to discharge the sample drawn up into the reaction vessel located at the dispensing position during the dispensing action sub-cycle.

[0120] When it is determined that there are attachments on the outer wall and / or tip of the sample dispensing needle 101, the sample analyzer 100 is controlled to use the second cleaning mode to clean the sample dispensing needle 101 in the sample dispensing action sub-cycle, and the sample dispensing needle 101 is controlled to dispensing the sample inside the needle.

[0121] Please see Figure 10 The sample dispensing procedure using the dispensing needle 101 includes a routine cleaning cycle and a sampling cycle. During the routine cleaning cycle, before dispensing, the dispensing needle 101 is moved to the second cleaning chamber to clean its inner and outer walls with a second cleaning solution. After cleaning in the second cleaning chamber, the dispensing needle 101 is moved to the first cleaning chamber to clean its inner and outer walls with a first cleaning solution. After cleaning in the first cleaning chamber, the dispensing needle 101 is moved back to the second cleaning chamber to clean its inner and outer walls with a second cleaning solution, thus completing the cleaning of the dispensing needle 101.

[0122] After the sampling needle 101 completes cleaning, it enters the sampling action cycle. The sampling action cycle T includes a sample aspiration sub-cycle t1 and a sample discharge sub-cycle t2. During the sample aspiration sub-cycle t1, the control device 70 controls the sampling needle 101 to aspirate the sample carried by the sample container located at the sample aspiration position. During the sample discharge sub-cycle t2, the control device 70 controls the sampling needle 101 to discharge the sample into the reaction container located at the sample discharge position.

[0123] Specifically, during the sampling action sub-cycle t1 of the sampling action cycle T, the control device 70 controls the first needle moving mechanism 102 to drive the dispensing needle 101 to the dispensing position, and controls the first power mechanism 103 to operate so that the dispensing needle 101 can draw up the sample carried by the sample container located at the dispensing position.

[0124] After sample aspiration is completed, the sample dispensing sub-cycle t2 begins. Control device 70 controls the first needle moving mechanism 102 to drive the dispensing needle 101 to the dispensing position and controls the first power mechanism 103 to dispense the sample into the reaction vessel located at the dispensing position, thus completing the sample dispensing operation. If the dispensing needle 101 needs to perform the next sample dispensing operation after dispensing, the dispensing needle cleaning and dispensing process can be repeated.

[0125] However, during the sampling process of the sampling needle 101, the contaminants in the sample to be tested may adhere to the outer wall of the sampling needle 101 or be adsorbed onto the tip of the sampling needle 101. In this case, in order to reduce the impact of the additional operation time required to remove the sample from the sampling needle 101 on the sample detection of the next cycle.

[0126] The control device 70 controls the sampling needle 101 to perform a sampling operation on the sample to aspirate the sample carried by the sample container located at the sampling position within the sampling operation cycle t1, and detects whether there are any attached substances on the outer wall and / or tip of the sampling needle 101.

[0127] When it is confirmed that there are no adhering substances on the outer wall and / or tip of the dispensing needle 101, the dispensing needle 101 is controlled to discharge the sample drawn up into the reaction vessel located at the dispensing position during the dispensing action sub-cycle t2.

[0128] When it is determined that there are attachments on the outer wall and / or tip of the sample dispensing needle 101, the sample analyzer 100 is controlled to use the second cleaning mode to clean the sample dispensing needle 101 in the sample dispensing action sub-cycle t2, and the sample dispensing needle 101 is controlled to dispense the sample inside the needle, so that there is no need to add an additional attachment treatment cycle and waste sample treatment cycle, so that the sample processing operation of the sample analyzer can be carried out in an orderly manner.

[0129] In some embodiments, the sample analyzer 100 further includes a needle detection device 90, which is communicatively connected to the control device 70 and is used to detect whether there are any deposits on the outer wall of the sample dispensing needle 101 and / or the tip of the sample dispensing needle 101.

[0130] After the sampling operation is performed on the sample by the sampling needle 101, or during the sampling operation of the sample by the sampling needle 101, the control device 70 is also used to:

[0131] The device receives the first detection information output by the needle detection device 90, and determines whether there are any attached substances on the outer wall or the tip of the sample needle 101 based on the first detection information, thereby performing the corresponding processing operation.

[0132] It should be understood that the terminology used in this specification is for the purpose of describing particular embodiments only and is not intended to limit the scope of the application. As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” are intended to include the plural forms unless the context clearly indicates otherwise.

[0133] It should also be understood that the term "and / or" as used in this specification and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes such combinations. It should be noted that, herein, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or system that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or system. Without further limitation, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or system that includes that element.

[0134] The sequence numbers of the embodiments in this application are for descriptive purposes only and do not represent the superiority or inferiority of the embodiments. The above descriptions are merely specific implementations of this application, but the scope of protection of this application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in this application, and these modifications or substitutions should all be covered within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A sample analyzer, characterized in that, include: A sample dispensing device includes a dispensing needle and a needle moving mechanism. The dispensing needle is used to aspirate a sample and add the sample to a reaction container, and the needle moving mechanism is used to drive the dispensing needle to move. A cleaning device includes a cleaning component, a liquid supply component, and a filter component. The cleaning component forms a receiving tank, and the receiving tank contains a first cleaning pool and a second cleaning pool. The first cleaning pool forms a first cleaning chamber with a first opening and a first liquid inlet, the first opening being located at the top of the first cleaning pool and the first liquid inlet being located at the side wall or bottom of the first cleaning pool. The second cleaning pool forms a second cleaning chamber with a second opening, the second opening being located at the top of the second cleaning pool, and the side wall and bottom of the second cleaning pool are closed structures. The receiving tank is provided with a first drain outlet, through which liquid overflowing from the first and second cleaning pools can be discharged. The filter component is disposed in the liquid flow path between the first and second openings and the first drain outlet, and at least partially covers the first drain outlet. The liquid supply component is used to supply a first cleaning solution to the first cleaning pool through the first liquid inlet and to supply a second cleaning solution to the sampling needle. The control device, wherein the sample analyzer is provided with a first cleaning mode and a second cleaning mode, is used for: Before the sample aspiration operation is performed on the sample, the sample analyzer is controlled to clean the sample aspiration needle using the first cleaning mode; After the sample aspiration operation is performed on the sample dispensing needle, and it is determined that there are adhering substances on the outer wall and / or tip of the dispensing needle, the sample analyzer is controlled to use the second cleaning mode to clean the dispensing needle, and the sample dispensing needle is controlled to discharge the sample inside the needle. In the first cleaning mode, the needle moving mechanism is controlled to drive the sampling needle to move sequentially to the second cleaning tank, the first cleaning tank and the second cleaning tank, and the cleaning device is controlled to clean the sampling needles located in the corresponding cleaning tanks sequentially. In the second cleaning mode, the needle moving mechanism is controlled to drive the sampling needle to the first cleaning tank and the cleaning device is controlled to clean the sampling needle located in the first cleaning tank; after the sampling needle in the first cleaning tank is cleaned, the needle moving mechanism is controlled to drive the sampling needle to the second cleaning tank and the cleaning device is controlled to clean the sampling needle located in the second cleaning tank.

2. The sample analyzer according to claim 1, characterized in that, In the second cleaning mode, during the cleaning process of the sampling needle located in the first cleaning tank, the control device is further configured to: The liquid supply component is controlled to supply the first cleaning solution to the first cleaning tank through the first liquid inlet, and the liquid supply component is also controlled to supply the second cleaning solution to the sampling needle, so that the sampling needle can discharge the sample inside the needle.

3. The sample analyzer according to claim 2, characterized in that, During the cleaning process of the sampling needle in the first cleaning tank, the control device is further used to: After the liquid supply component supplies the second cleaning solution to the sampling needle for a first duration, the liquid supply component is controlled to stop supplying the second cleaning solution to the sampling needle, and the liquid supply component is controlled to continuously supply the first cleaning solution to the first cleaning tank through the first liquid inlet. After the first cleaning fluid has been supplied for a second duration, the supply component is controlled to stop supplying the first cleaning fluid to the first cleaning tank.

4. The sample analyzer according to claim 1, characterized in that, The sampling device further includes a power mechanism for providing power to the sampling needle for sample aspiration and dispensing. In the second cleaning mode, during the cleaning of the sampling needle located in the first cleaning tank, the control device is further configured to: The liquid supply component is controlled to supply the first cleaning solution to the first cleaning tank through the first liquid inlet, and the power mechanism is controlled to provide power to the sampling needle so that the sampling needle can discharge the sample inside the needle.

5. The sample analyzer according to claim 1, characterized in that, The control device controls the sampling device to aspirate the sample from the sample container at the sampling position and discharge the sample into the reaction container at the discharge position during the sampling operation cycle. The sampling operation cycle includes a sampling sub-cycle and a discharge sub-cycle. During the sampling sub-cycle, the control device controls the sampling needle to aspirate the sample from the sample container at the sampling position; and during the discharge sub-cycle, the control device controls the sampling needle to discharge the sample into the reaction container at the discharge position. The control device is also used for: During the sampling action cycle, the sampling needle is controlled to perform a sampling operation on the sample to draw the sample carried by the sample container located at the sampling position, and the presence of any adhering substances on the outer wall and / or tip of the sampling needle is detected. When it is determined that there are no adhering substances on the outer wall and / or tip of the dispensing needle, the dispensing needle is controlled to discharge the sample drawn up into the reaction vessel located at the dispensing position during the dispensing action sub-cycle; When it is determined that there are deposits on the outer wall and / or tip of the sample dispensing needle, the sample analyzer is controlled to use the second cleaning mode to clean the sample dispensing needle in the sample ejection sub-cycle, and the sample dispensing needle is controlled to eject the sample inside the needle.

6. The sample analyzer according to claim 1, characterized in that, The diameter of the second opening is smaller than the diameter of the first opening.

7. The sample analyzer according to claim 1, characterized in that, The receiving tank also forms an overflow pool with a third opening and a second drain outlet. The third opening is located at the top of the overflow pool, and the second drain outlet is located on the side wall or bottom of the overflow pool. The top of the overflow pool is higher than the top of the first cleaning pool and the top of the second cleaning pool, and the top of the receiving tank is higher than the top of the overflow pool. The liquid overflowing from the first cleaning tank and the second cleaning tank can enter the overflow tank through the third opening and be discharged through the second drain outlet.

8. The sample analyzer according to claim 1, characterized in that, The sample analyzer also includes a needle detection device, which is communicatively connected to the control device and is used to detect whether there are any attached substances on the outer wall of the sample dispensing needle and / or the tip of the sample dispensing needle. After the sample addition operation is performed on the sample, or during the sample addition operation, the control device is further configured to: The device receives the first detection information output by the needle detection device and determines whether there are any attached substances on the outer wall of the sample dispensing needle or the tip of the sample dispensing needle based on the first detection information.

9. A cleaning device, characterized in that, include: A cleaning component is provided, forming a receiving tank, within which a first cleaning pool and a second cleaning pool are disposed. The first cleaning pool forms a first cleaning chamber with a first opening and a first liquid inlet, the first opening being located at the top of the first cleaning pool and the first liquid inlet being located at the side wall or bottom of the first cleaning pool. The second cleaning pool forms a second cleaning chamber with a second opening, the second opening being located at the top of the second cleaning pool, and the side wall and bottom of the second cleaning pool are closed structures. The receiving tank is provided with a first drain outlet, through which liquid overflowing from the first and second cleaning pools can be discharged. and A filter element at least partially covers the first drain port, and / or the filter element is disposed in the liquid flow path between the first opening and the second opening to the first drain port.

10. The cleaning apparatus according to claim 9, characterized in that, The diameter of the second opening is smaller than the diameter of the first opening.

11. The cleaning apparatus according to claim 9, characterized in that, The receiving tank also forms an overflow pool with a third opening and a second drain outlet. The third opening is located at the top of the overflow pool, and the second drain outlet is located on the side wall or bottom of the overflow pool. The top of the overflow pool is higher than the top of the first cleaning pool and the top of the second cleaning pool, and the top of the receiving tank is higher than the top of the overflow pool. The liquid overflowing from the first cleaning tank and the second cleaning tank can enter the overflow tank through the third opening and be discharged through the second drain outlet.

12. The cleaning apparatus according to claim 9, characterized in that, The filter component includes a support member and a filter screen disposed on the support member, and the filter component is detachably installed on the cleaning component via the support member.

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