A composite scalp anti-aging care composition containing a schizosaccharomyces ferment filtrate and its use

Abstract

This invention discloses a compound scalp anti-aging care composition containing Bifida Ferment Lysate filtrate and its application. The invention employs a targeted fermentation process to prepare an optimized Bifida Ferment Lysate filtrate. By controlling the composition of the fermentation medium and process parameters, the product is enriched with small-molecule active ingredients, making it easier for scalp hair follicles to absorb. Compared to conventional fermentation filtrate, its barrier repair and antioxidant effects are enhanced, and it exhibits stronger compatibility with the scalp environment.

Description

Technical Field

[0001] This invention relates to the field of daily chemical care technology, specifically to a composite scalp anti-aging care composition containing Bifida ferment filtrate and its application. Background Technology

[0002] Currently, influenced by multiple factors such as unbalanced diet, increased mental stress, irregular work and rest, and environmental pollutants, scalp health problems are showing a diversified and younger trend. Among them, people with oily and sensitive scalps simultaneously face problems such as excessive sebum secretion, scalp redness and itching, and a weakened scalp barrier. Some also experience decreased hair follicle vitality and increased hair loss. The core cause of these problems lies in the imbalance of the scalp's microecology, leading to the proliferation of harmful bacteria and disordered sebaceous gland secretion. At the same time, the scalp's stratum corneum barrier is damaged, making it unable to resist external stimuli. Conventional single-function scalp anti-aging care products are insufficient to achieve comprehensive improvement.

[0003] In existing technologies, many products for scalp anti-aging care suffer from single efficacy or conflicting ingredients: oil-control products often add strong surfactants or oil-absorbing ingredients, which can easily aggravate scalp barrier damage and exacerbate sensitivity; soothing and repairing products mostly focus on moisturizing and anti-inflammation, but cannot effectively regulate sebum secretion, and long-term use can easily lead to oily scalp and clogged hair follicles; anti-hair loss products often add ingredients such as ginger extract and caffeine, but they have poor compatibility with sensitive scalps and lack targeted regulation of the scalp microecology, resulting in limited anti-hair loss effects.

[0004] Bifida Ferment Lysate, an active ingredient with both repairing and antioxidant properties, has been widely recognized for its role in skin barrier repair and free radical scavenging. However, current fermentation processes are mostly designed for facial skin, and the molecular weight and polarity of the active ingredients in the product are difficult to match the absorption characteristics of scalp hair follicles. Furthermore, using Bifida Ferment Lysate alone cannot achieve oil control and hair loss prevention effects. In addition, how to scientifically combine Bifida Ferment Lysate with oil-controlling and hair loss-preventing active ingredients to avoid antagonistic effects between components, while simultaneously improving the stability and longevity of the composition in the scalp environment, remains an unsolved technical challenge in this field.

[0005] Based on this, a compound scalp anti-aging care composition was developed, which is based on the filtrate of Bifida ferment lysate prepared by an optimized fermentation process, and compounded with oil-controlling and hair loss-preventing active ingredients. This composition can synergistically achieve scalp microecological regulation, sebum secretion control, barrier repair and hair follicle vitality enhancement, and has important practical application value and market prospects. Summary of the Invention

[0006] The purpose of this invention is to overcome the shortcomings of existing scalp anti-aging care products, such as limited efficacy, poor ingredient compatibility, and inability to address diverse scalp problems. This invention provides a composite scalp anti-aging care composition containing Bifida Ferment Lysate filtrate. This composition optimizes the Bifida Ferment Lysate fermentation process to improve the scalp compatibility of the active ingredients, while also incorporating oil-controlling, hair loss-preventing, and microecological regulating ingredients to achieve a synergistic triple effect of oil control and hair loss prevention, soothing repair, and microecological balance.

[0007] A compound scalp anti-aging care composition containing Bifida ferment filtrate, comprising, by weight percentage: 2-70% Bifida ferment filtrate, 0.001-4% Sapindus mukorossi peel extract, 2-6% oil-controlling active ingredient, 1-4% anti-hair loss active ingredient, 0.5-2% microecological regulator, and the balance being a scalp compatibility carrier; wherein the oil-controlling active ingredient is a compound of nicotinamide and zinc salt in a mass ratio of 3:1-5:1; the anti-hair loss active ingredient is a compound of ginsenoside Rg1 and saw palmetto extract in a mass ratio of 1:2-1:4; and the microecological regulator is a compound of Lactobacillus curvature freeze-dried bacterial powder and fructooligosaccharides in a mass ratio of 1:3-1:5; The method for preparing the Bifida ferment filtrate includes: (1) Pretreatment of bacterial strain: Inoculate the Bifida yeast strain into sterile physiological saline, shake and activate for 30-40 min to obtain a bacterial suspension with an OD600 value of 0.8-1.0; (2) Seed culture: The bacterial suspension is inoculated into the seed culture medium at an inoculation rate of 3-5%, and cultured statically at 37-39℃ under anaerobic conditions for 20-24 hours to obtain the seed culture; the seed culture medium contains 25-35 g / L glucose, 12-18 g / L whey protein hydrolysate, 6-10 g / L yeast extract, 0.3-0.8 g / L magnesium sulfate, and 0.1-0.3 g / L vitamin C, and the pH value of the seed culture medium is 6.2-6.8; (3) Directional fermentation: The seed liquid is inoculated into the fermentation medium at an inoculation rate of 4-6%, and fermented at 37-39℃ under anaerobic conditions for 36-48 hours. Carbon source mixture is added every 12 hours, and the pH value is controlled at 6.0-6.5. The fermentation medium contains 15-20 g / L soybean peptone, 8-12 g / L galactooligosaccharides, 5-8 g / L yeast extract, 1.5-2.5 g / L sodium dihydrogen phosphate, and 0.01-0.03 g / L zinc ions. (4) Product purification: The fermentation broth is centrifuged at 4-6℃ and 12000-14000r / min for 25-35min. The supernatant is filtered through a 0.2μm filter membrane for sterilization, and then ultrafiltered through a 3000Da ultrafiltration membrane. The permeate is collected and concentrated to 1 / 5 of the original volume by vacuum freeze drying to obtain the Bifida ferment filtrate.

[0008] Beneficial effects (1) The present invention uses a directional fermentation process to prepare an optimized Bifida ferment filtrate. By adjusting the composition of the fermentation medium and the process parameters, the product is rich in small molecule active ingredients, which are more easily absorbed by the hair follicles of the scalp. Compared with conventional fermentation filtrate, its barrier repair and antioxidant effects are improved, and its compatibility with the scalp environment is stronger.

[0009] (2) This invention uses a scientific compound of oil-controlling, hair loss-preventing and microecological regulating ingredients. The ingredients work synergistically to achieve the triple effect of "oil control-repair-hair loss prevention". It can simultaneously improve multiple problems such as oily scalp, sensitive redness, and increased hair loss. Compared with single-effect products, it has a wider range of applicable scenarios and more comprehensive care effects.

[0010] (3) The composition of the present invention has a wide range of applications and can be used to prepare a variety of anti-aging scalp care products to meet the needs of different scenarios such as daily cleaning, intensive repair, and hair follicle care. It has broad market application prospects. Detailed Implementation

[0011] One embodiment of the present invention provides a compound scalp anti-aging care composition containing Bifida ferment filtrate, comprising, by weight percentage: 2-70% Bifida ferment filtrate, 0.001-4% Sapindus mukorossi peel extract, 2-6% oil-controlling active ingredient, 1-4% anti-hair loss active ingredient, 0.5-2% microecological regulator, and the balance being a scalp compatibility carrier; the oil-controlling active ingredient is a compound of nicotinamide and zinc salt in a mass ratio of 3:1-5:1; the anti-hair loss active ingredient is a compound of ginsenoside Rg1 and saw palmetto extract in a mass ratio of 1:2-1:4; and the microecological regulator is a compound of Lactobacillus curvature freeze-dried bacterial powder and fructooligosaccharides in a mass ratio of 1:3-1:5.

[0012] The preparation method of Bifida ferment filtrate includes: (1) Pretreatment of bacterial strain: Inoculate the bifida yeast strain into sterile physiological saline, shake and activate for 30-40 min to obtain a bacterial suspension with an OD600 value of 0.8-1.0.

[0013] (2) Seed culture: Inoculate the bacterial suspension into the seed culture medium at an inoculation rate of 3-5%, and incubate at 37-39℃ under anaerobic conditions for 20-24 hours to obtain the seed culture; the seed culture medium contains 25-35 g / L glucose, 12-18 g / L whey protein hydrolysate, 6-10 g / L yeast extract, 0.3-0.8 g / L magnesium sulfate, and 0.1-0.3 g / L vitamin C, and the pH value of the seed culture medium is 6.2-6.8.

[0014] (3) Directional fermentation: Inoculate the seed culture into the fermentation medium at an inoculum rate of 4-6%, and ferment at 37-39℃ under anaerobic conditions for 36-48 hours. Replenish the carbon source mixture every 12 hours and control the pH value to 6.0-6.5. The fermentation medium contains 15-20 g / L soybean peptone, 8-12 g / L galactooligosaccharides, 5-8 g / L yeast extract, 1.5-2.5 g / L sodium dihydrogen phosphate, and 0.01-0.03 g / L zinc ions. The carbon source mixture is a mixture of glucose and maltitol in water at a mass ratio of 2:1, with a total carbon source concentration of 50 g / L.

[0015] (4) Product purification: The fermentation broth is centrifuged at 4-6℃ and 12000-14000r / min for 25-35min. The supernatant is filtered through a 0.2μm filter membrane for sterilization, and then ultrafiltered through a 3000Da ultrafiltration membrane. The permeate is collected and concentrated to 1 / 5 of the original volume by vacuum freeze drying to obtain the Bifida ferment filtrate.

[0016] The fermentation product filtrate of Bifida ferment lysate prepared by a specific method is rich in small molecule polysaccharides, amino acid complexes and bioactive peptides with a molecular weight of 500-3000 Da, of which the content of bioactive peptides is not less than 1.2 mg / mL.

[0017] In some embodiments, the compound scalp anti-aging care composition containing Bifida Ferment Lysate contains, by weight percentage: 2-50% Bifida Ferment Lysate, 0.001-3% Sapindus mukorossi peel extract, 3-5% oil-controlling active ingredient, 2-3% anti-hair loss active ingredient, 0.8-1.5% microecological regulator, and the balance being a scalp compatibility carrier.

[0018] Optionally, the Sapindus mukorossi pericarp extract can be prepared by the following method: Sapindus mukorossi pericarp is pulverized and passed through a 20-40 mesh sieve to remove seeds and impurities. Water is added and heated under reflux at a material-to-liquid ratio of 1:8-1:15 (g:mL) for 1-2 hours, repeating the reflux twice. The filtrate is then filtered. The filtrate is concentrated under reduced pressure (50-60℃, -0.06~-0.08MPa) to a relative density of 1.05-1.15 (60℃). The concentrate is dried to obtain the Sapindus mukorossi pericarp extract.

[0019] In some embodiments, the zinc salt is selected from one or both of zinc gluconate and zinc lactate.

[0020] In some embodiments, the fatty acid content of the saw palmetto extract is not less than 45%. The extraction process of the saw palmetto extract is as follows: the saw palmetto fruit is crushed and extracted twice by reflux with 70% ethanol, 2 hours each time. The extracts are combined, concentrated under reduced pressure until there is no alcohol odor, purified by macroporous resin, the eluent is collected and dried to obtain the saw palmetto extract, wherein the fatty acid content is not less than 45%.

[0021] In some embodiments, the viable count of the freeze-dried Lactobacillus curvature powder is not less than 1 × 10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 2-8, and the purity is not less than 95%. This microecological regulator can selectively inhibit the growth of harmful bacteria on the scalp (such as Malassezia), promote the colonization of beneficial bacteria, and maintain the balance of the scalp's microecology.

[0022] In some embodiments, the scalp compatibility carrier is selected from one or more combinations of deionized water, glycerin, 1,3-butanediol, panthenol, ceramide NP, hyaluronic acid, and polyglycerol-4-decanoate.

[0023] In some embodiments, the ceramide NP accounts for 0.2-0.5% of the scalp compatibility carrier by mass.

[0024] In some embodiments, hyaluronic acid accounts for 0.01-0.3% of the mass of the scalp compatibility carrier.

[0025] In some embodiments, the volume of carbon source mixture replenished each time is 1-5% of the fermentation medium volume.

[0026] Another embodiment of the present invention provides a method for preparing the above-mentioned composite scalp anti-aging care composition, comprising the following steps: Add the extract of Sapindus mukorossi fruit peel, oil-controlling active ingredients, hair loss-preventing active ingredients, and microecological regulators to the filtrate of Bifida ferment lysate, and ultrasonically disperse for 10-15 minutes (ultrasonic power 300W, frequency 40kHz can be selected) to obtain an active compound solution.

[0027] Add the active compound solution to the scalp-compatible carrier, stir at 200-300 r / min for 25-30 min, and then homogenize at 20-25 MPa pressure for 5-10 min.

[0028] Another embodiment of the present invention provides a scalp anti-aging care product, comprising the above-mentioned compound scalp anti-aging care composition.

[0029] In some embodiments, scalp anti-aging care products include one or more of the following: scalp oil-controlling essence, anti-hair loss shampoo, scalp repair pre-wash, and hair follicle nourishing liquid.

[0030] The following are examples and comparative examples.

[0031] 1. The preparation method of Bifida ferment filtrate is as follows: (1) Pretreatment of bacterial strain: Bifida ferment lysate was inoculated into sterile physiological saline and activated by shaking for 35 min to obtain a bacterial suspension with an OD600 value of 0.8.

[0032] (2) Seed culture: The bacterial suspension was inoculated into the seed culture medium at an inoculation rate of 4%, and cultured statically at 37°C under anaerobic conditions for 20 hours to obtain the seed culture. The seed culture medium contained 30 g / L glucose, 15 g / L whey protein hydrolysate, 8 g / L yeast extract, 0.5 g / L magnesium sulfate, and 0.2 g / L vitamin C. The pH of the seed culture medium was 6.5.

[0033] (3) Directional fermentation: The seed culture was inoculated into the fermentation medium at a 4% inoculum rate and fermented at 37℃ under anaerobic conditions for 36 hours. A carbon source mixture was added every 12 hours, and the pH was controlled at 6.5. The fermentation medium contained 15 g / L soybean peptone, 10 g / L galactooligosaccharides, 6 g / L yeast extract, 2 g / L sodium dihydrogen phosphate, and 0.02 g / L zinc ions. The carbon source mixture was a mixture of glucose and maltitol in water at a mass ratio of 2:1, with a total carbon source concentration of 50 g / L. The volume of the carbon source mixture added each time was 2% of the fermentation medium volume.

[0034] (4) Product purification: The fermentation broth was centrifuged at 5℃ and 12000r / min for 30min. The supernatant was filtered through a 0.2μm filter membrane for sterilization, and then ultrafiltered through a 3000Da ultrafiltration membrane. The permeate was collected and concentrated to 1 / 5 of the original volume by vacuum freeze drying to obtain the Bifida ferment filtrate.

[0035] 2. The scalp compatibility carrier is formulated from deionized water, glycerin, 1,3-butanediol, panthenol, ceramide NP, and hyaluronic acid. Ceramide NP accounts for 0.3% of the scalp compatibility carrier by mass. Hyaluronic acid accounts for 0.01% of the scalp compatibility carrier by mass. Glycerin accounts for 5% of the scalp compatibility carrier by mass. 1,3-Butanediol accounts for 8% of the scalp compatibility carrier by mass. Panthenol accounts for 6% of the scalp compatibility carrier by mass.

[0036] 3. The preparation method of the compound scalp anti-aging care composition is as follows: Oil-controlling active ingredients, anti-hair loss active ingredients, and microecological regulators were added to the filtrate of Bifida ferment lysate and ultrasonically dispersed for 10 minutes (ultrasonic power 300W, frequency 40kHz) to obtain an active composite solution.

[0037] The active compound solution was added to the scalp-compatible carrier and stirred at 200 r / min for 25 min, followed by homogenization at 20 MPa pressure for 5 min.

[0038] 4. The preparation method of Sapindus mukorossi fruit peel extract is as follows: The pericarp of *Sapindus mukorossi* was pulverized and passed through a 40-mesh sieve to remove seeds and impurities. Water was added and refluxed at a ratio of 1:8 (g:mL) for 1.5 hours, repeated twice. The mixture was then filtered. The filtrate was concentrated under reduced pressure (60℃, -0.07MPa) to a relative density of 1.05 (60℃). The concentrate was dried to obtain the *Sapindus mukorossi* pericarp extract.

[0039] Example 1 The compound scalp anti-aging care composition, by weight percentage, consists of: 8% Bifida ferment filtrate, 1% Sapindus mukorossi peel extract, 2% oil-controlling active ingredient (nicotinamide: zinc gluconate = 3:1), 1% anti-hair loss active ingredient (ginsenoside Rg1: saw palmetto extract = 1:2), 0.5% microecological regulator (Lactobacillus curvature freeze-dried powder: fructooligosaccharides = 1:3), and the remainder being a scalp compatibility carrier. The fatty acid content of the saw palmetto extract is 55%; the viable count of the Lactobacillus curvature freeze-dried powder is 1×10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 4-6, and the purity is 98%.

[0040] Example 2 The compound scalp anti-aging care composition, by weight percentage, consists of: 12% Bifida ferment filtrate, 2% Sapindus mukorossi peel extract, 3% oil-controlling active ingredient (nicotinamide: zinc gluconate = 3:1), 2% anti-hair loss active ingredient (ginsenoside Rg1: saw palmetto extract = 1:2), 0.8% microecological regulator (Lactobacillus curvature freeze-dried powder: fructooligosaccharides = 1:3), and the remainder being a scalp compatibility carrier. The fatty acid content of the saw palmetto extract is 55%; the viable count of the Lactobacillus curvature freeze-dried powder is 1×10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 4-6, and the purity is 98%.

[0041] Example 3 The compound scalp anti-aging care composition, by weight percentage, consists of: 15% Bifida ferment filtrate, 1% Sapindus mukorossi peel extract, 5% oil-controlling active ingredient (nicotinamide: zinc gluconate = 3:1), 3% anti-hair loss active ingredient (ginsenoside Rg1: saw palmetto extract = 1:2), 1.5% microecological regulator (Lactobacillus curvature freeze-dried powder: fructooligosaccharides = 1:3), and the remainder being a scalp compatibility carrier. The fatty acid content of the saw palmetto extract is 55%; the viable count of the Lactobacillus curvature freeze-dried powder is 1×10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 4-6, and the purity is 98%.

[0042] Example 4 The compound scalp anti-aging care composition, by weight percentage, consists of: 50% Bifida ferment filtrate, 0.005% Sapindus mukorossi peel extract, 2% oil-controlling active ingredient (nicotinamide: zinc gluconate = 3:1), 1% anti-hair loss active ingredient (ginsenoside Rg1: saw palmetto extract = 1:2), 0.5% microecological regulator (Lactobacillus curvature freeze-dried powder: fructooligosaccharides = 1:3), and the remainder being a scalp compatibility carrier. The fatty acid content of the saw palmetto extract is 55%; the viable count of the Lactobacillus curvature freeze-dried powder is 1×10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 4-6, and the purity is 98%.

[0043] Comparative Example 1 The compound scalp anti-aging care composition, by weight percentage, consists of: 1% Bifida ferment filtrate, 0.5% Sapindus mukorossi peel extract, 1% oil-controlling active ingredient (nicotinamide: zinc gluconate = 3:1), 5% anti-hair loss active ingredient (ginsenoside Rg1: saw palmetto extract = 1:2), 4% microecological regulator (Lactobacillus curvature freeze-dried powder: fructooligosaccharides = 1:3), and the remainder being a scalp compatibility carrier. The fatty acid content of the saw palmetto extract is 55%; the viable count of the Lactobacillus curvature freeze-dried powder is 1×10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 4-6, and the purity is 98%.

[0044] Comparative Example 2 The compound scalp anti-aging care composition, by weight percentage, consists of: 75% Bifida ferment filtrate, 0.5% Sapindus mukorossi peel extract, 8% oil-controlling active ingredient (nicotinamide: zinc gluconate = 3:1), 0.5% anti-hair loss active ingredient (ginsenoside Rg1: saw palmetto extract = 1:2), 0.2% microecological regulator (Lactobacillus curvature freeze-dried powder: fructooligosaccharides = 1:3), and the remainder being a scalp compatibility carrier. The fatty acid content of the saw palmetto extract is 55%; the viable count of the Lactobacillus curvature freeze-dried powder is 1×10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 4-6, and the purity is 98%.

[0045] Comparative Example 3 The compound scalp anti-aging care composition, by weight percentage, consists of: 1% Sapindus mukorossi fruit peel extract, 2% oil-controlling active ingredient (nicotinamide: zinc gluconate = 3:1), 1% anti-hair loss active ingredient (ginsenoside Rg1: saw palmetto extract = 1:2), 0.5% microecological regulator (Lactobacillus curvature freeze-dried powder: fructooligosaccharides = 1:3), and the balance being a scalp compatibility carrier. The fatty acid content of the saw palmetto extract is 55%; the viable count of the Lactobacillus curvature freeze-dried powder is 1×10⁻⁶. 9 CFU / g; the degree of polymerization of fructooligosaccharides is 4-6, and the purity is 98%.

[0046] Test case (1) Test sample: The compositions of the examples and comparative examples were prepared into scalp oil control essences, with the composition accounting for 3% of the scalp oil control essence by mass, and the remainder being conventional and acceptable excipients.

[0047] (2) Test subjects: 180 volunteers who met the test criteria were selected. They were aged 20-45 years old and had problems such as oily scalp, sensitive redness, mild hair loss (50-100 hairs per day) and scalp microecological imbalance (excessive number of Malassezia). They were randomly divided into 6 groups of 30 people each. The above 6 samples were used once a day for 8 consecutive weeks.

[0048] (3) Test environment: 25℃, humidity 60%. Volunteers maintained the same shampooing frequency during the test and did not use other scalp anti-aging care products.

[0049] Test Project (1) Scalp sebum reduction rate: Using a scalp sebum tester, the amount of scalp sebum secreted on the top of the head of volunteers before and after use was measured, and the average value and sebum reduction rate of each group were calculated. Sebum reduction rate = (amount of sebum before use - amount of sebum after use) / amount of sebum before use × 100%.

[0050] (2) Soothing effect on sensitive scalp: The redness index of the scalp was detected by a skin erythema instrument (0-10 points, the higher the score, the more severe the redness). The redness index before and after use was counted and the redness index reduction rate was calculated. At the same time, the subjective feelings of volunteers' scalp itching and stinging were recorded and divided into significant improvement (itching and stinging completely disappeared), effective improvement (itching and stinging were significantly reduced), and no improvement (no change in symptoms). The total effective rate was calculated as (number of people with significant improvement + number of people with effective improvement) / total number of people × 100%.

[0051] (3) Hair loss improvement effect: The hair counting method was used to count the number of natural hairs that volunteers lost each day before use and after 8 weeks of use, and the hair loss reduction rate was calculated. Hair loss reduction rate = (number of hairs lost before use - number of hairs lost after use) / number of hairs lost before use × 100%.

[0052] (4) Take scalp epidermal fungal samples from volunteers and detect the number of Malassezia (CFU / g) by microbial culture method, and calculate the Malassezia inhibition rate after 8 weeks of use. Malassezia inhibition rate = (number before use - number after use) / number before use × 100%.

[0053] The test results are shown in Table 1.

[0054] Table 1

[0055] As can be seen from Table 1, compared with the comparative example, the composition in the examples uses specific components to effectively improve the scalp environment and achieve a synergistic effect of oil control and hair loss prevention, soothing and repair, and microecological balance.

[0056] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

[0057] For those skilled in the art, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. A compound scalp anti-aging care composition containing Bifida ferment filtrate, characterized in that, By weight percentage, it comprises: 2-70% Bifida ferment filtrate, 0.001-4% Sapindus mukorossi peel extract, 2-6% oil-controlling active ingredient, 1-4% anti-hair loss active ingredient, 0.5-2% microecological regulator, and the balance being a scalp compatibility carrier; the oil-controlling active ingredient is a compound of nicotinamide and zinc salt, with a mass ratio of 3:1-5:1; the anti-hair loss active ingredient is a compound of ginsenoside Rg1 and saw palmetto extract, with a mass ratio of 1:2-1:4; the microecological regulator is a compound of Lactobacillus curvature freeze-dried bacterial powder and fructooligosaccharides, with a mass ratio of 1:3-1:5; The method for preparing the Bifida ferment filtrate includes: (1) Pretreatment of bacterial strain: Inoculate the Bifida yeast strain into sterile physiological saline, shake and activate for 30-40 min to obtain a bacterial suspension with an OD600 value of 0.8-1.0; (2) Seed culture: The bacterial suspension is inoculated into the seed culture medium at an inoculation rate of 3-5%, and cultured statically at 37-39℃ under anaerobic conditions for 20-24 hours to obtain the seed culture; the seed culture medium contains 25-35 g / L glucose, 12-18 g / L whey protein hydrolysate, 6-10 g / L yeast extract, 0.3-0.8 g / L magnesium sulfate, and 0.1-0.3 g / L vitamin C, and the pH value of the seed culture medium is 6.2-6.8; (3) Directional fermentation: The seed liquid is inoculated into the fermentation medium at an inoculation rate of 4-6%, and fermented at 37-39℃ under anaerobic conditions for 36-48 hours. Carbon source mixture is added every 12 hours, and the pH value is controlled at 6.0-6.

5. The fermentation medium contains 15-20 g / L soybean peptone, 8-12 g / L galactooligosaccharides, 5-8 g / L yeast extract, 1.5-2.5 g / L sodium dihydrogen phosphate, and 0.01-0.03 g / L zinc ions. (4) Product purification: The fermentation broth is centrifuged at 4-6℃ and 12000-14000r / min for 25-35min. The supernatant is filtered through a 0.2μm filter membrane for sterilization, and then ultrafiltered through a 3000Da ultrafiltration membrane. The permeate is collected and concentrated to 1 / 5 of the original volume by vacuum freeze drying to obtain the Bifida ferment filtrate.

2. The composite scalp anti-aging care composition according to claim 1, characterized in that, By weight percentage, it comprises: 2-50% of the Bifida ferment filtrate, 0.005-3% of the Sapindus mukorossi peel extract, 3-5% of the oil-controlling active ingredient, 2-3% of the hair loss-preventing active ingredient, 0.8-1.5% of the microecological regulator, and the balance being the scalp compatibility carrier.

3. The composite scalp anti-aging care composition according to claim 1, characterized in that, The zinc salt is selected from one or two of zinc gluconate and zinc lactate; the fatty acid content of the saw palmetto extract is not less than 45%; the viable count of the freeze-dried Lactobacillus curvature powder is not less than 1×10⁻⁶. 9 CFU / g; the degree of polymerization of the oligofructose is 2-8, and the purity is not less than 95%.

4. The composite scalp anti-aging care composition according to any one of claims 1-3, characterized in that, The scalp compatibility carrier is selected from one or more combinations of deionized water, glycerin, 1,3-butanediol, panthenol, ceramide NP, hyaluronic acid, and polyglycerol-4-decanoate.

5. The composite scalp anti-aging care composition according to claim 4, characterized in that, The ceramide NP accounts for 0.2-0.5% of the mass of the scalp compatibility carrier.

6. The composite scalp anti-aging care composition according to claim 4, characterized in that, The hyaluronic acid accounts for 0.01-0.3% of the mass of the scalp compatibility carrier.

7. The composite scalp anti-aging care composition according to any one of claims 1-3, characterized in that, Each time the carbon source mixture is replenished, the volume is 1-5% of the fermentation medium volume.

8. A method for preparing the composite scalp anti-aging care composition according to any one of claims 1-7, characterized in that, Includes the following steps: Add the Sapindus mukorossi fruit peel extract, the oil-controlling active ingredient, the hair loss-preventing active ingredient, and the microecological regulator to the Bifida ferment filtrate, and ultrasonically disperse for 10-15 minutes to obtain an active composite liquid; The active composite liquid is added to the scalp-compatible carrier and stirred at 200-300 r / min for 25-30 min, followed by homogenization at 20-25 MPa pressure for 5-10 min.

9. A scalp anti-aging care product, characterized in that, Includes the composite scalp anti-aging care composition according to any one of claims 1-7.

10. The scalp anti-aging care product according to claim 9, characterized in that, The scalp anti-aging care products include one or more of the following: scalp oil-control essence, anti-hair loss shampoo, scalp repair pre-wash, and hair follicle nourishing liquid.

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