Response surface methodology-based process method for optimizing extraction of total flavonoids from stems and leaves of herba houttuyniae

By optimizing the extraction process of total flavonoids from the stems and leaves of Houttuynia cordata using response surface methodology, the problem of low extraction rate was solved, achieving efficient flavonoid extraction, improving resource utilization and reducing production costs.

CN122124151APending Publication Date: 2026-06-02HUBEI YIYANG BIOTECHNOLOGY CO LTD +1
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Patent Information

Application Number
CN202610188921.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-02-10
Publication Date
2026-06-02

AI Technical Summary

Technical Problem

The existing technology has a low flavonoid extraction rate from the stems and leaves of Houttuynia cordata, which leads to resource waste and high production costs, making it difficult to achieve industrial utilization.

Method used

The extraction process of total flavonoids from the stems and leaves of Houttuynia cordata was optimized using response surface methodology. Through single-factor experiments and response surface design, the optimal extraction conditions, including ethanol concentration, extraction temperature, extraction time, and liquid-to-solid ratio, were determined. A second-order polynomial regression model was established to optimize the combination of extraction parameters.

Benefits of technology

The extraction rate of flavonoids from the stems and leaves of Houttuynia cordata was improved to 32.47±0.05 mg/g. The optimization results were stable and reliable, providing a theoretical basis and laying the foundation for the full utilization of resources and cost reduction.

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Abstract

The invention discloses a process method for optimizing cordate houttuynia stem and leaf total flavone extraction based on a response surface method.The process method relates to the technical field of natural product extraction and comprises the following steps that 1, dried and smashed cordate houttuynia stem and leaf powder is taken; step 2, performing total flavone extraction on the herba houttuyniae stem and leaf powder by adopting an ultrasonic mode, selecting four factors including ethanol concentration, extraction temperature, extraction time and liquid-material ratio as single factors to perform a single factor experiment, and establishing a second-order polynomial regression model by adopting a response surface design experiment and taking the total flavone content as a response value to predict an optimal extraction condition; 3, determining an optimized extraction parameter combination according to the model; and step 4, executing extraction operation according to the optimized extraction parameter combination. According to the method, the extraction process of the total flavonoids in the cordate houttuynia stems and leaves is optimized by utilizing the response surface method, the process capable of effectively extracting the flavonoids in the cordate houttuynia stems and leaves is determined, and a certain theoretical basis is provided for research and utilization of the flavonoids in the cordate houttuynia stems and leaves.
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