Non-invasive oral cell collection device suitable for automated testing

Abstract

The application discloses a non-transfer oral cavity cell collecting device suitable for automatic inspection, and relates to the technical field of DNA sample collection. The supporting base is provided with a first supporting part and a second supporting part, and openings are formed in the first supporting part and the second supporting part. When the first supporting part and the second supporting part are in a first working state, there is a spacing interval between the first supporting part and the second supporting part; when the first supporting part and the second supporting part are in a second working state, at least part of the structures of the first supporting part and the second supporting part are superimposed. A first folding structure is connected between the collecting card and the first supporting part or the second supporting part, and after the first folding structure is folded, the collecting card is clamped between the superimposed structures of the first supporting part and the second supporting part. At least part of the collecting part on the collecting card is located between the superimposed structures of the two openings, so that the sample transfer step in the traditional operation is avoided, sample loss and pollution in the transfer process are avoided, and the original enrichment amount of DNA is ensured.

Description

Technical Field

[0001] This invention relates to the field of DNA sample collection technology, and in particular to a non-transferable oral cell collection device suitable for automated testing. Background Technology

[0002] Currently, there are two main methods for collecting DNA samples from individuals: blood collection and oral cell collection. While blood collection yields high-quality DNA, it is complex, invasive, and poses biosafety risks. Oral cell collection, on the other hand, is non-invasive, convenient, and safe, and has become the mainstream sampling method. Current oral cell collection methods often involve scraping with a cotton swab and allowing it to air dry, or scraping from the buccal mucosa with a cotton pad and transferring the sample to an oral cell collection card for drying and preservation. The former (cotton swab collection) cannot be followed by subsequent batch processing such as punching, causing inconvenience for large-scale testing. The latter involves a transfer step, making the process cumbersome and significantly reducing the quantity and uniformity of collected oral cells, resulting in a low single-pass DNA detection rate.

[0003] Furthermore, for automated DNA testing laboratories (or smart DNA laboratories) with high automation requirements, existing oral cell collection cards mostly use rigid cardboard supports, which can lead to problems such as unstable gripping during automated testing by robotic arms. Additionally, because the collection cards have a cover section, the punching operation required for automated testing cannot be performed. Summary of the Invention

[0004] The purpose of this invention is to provide a non-transferable oral cell collection device suitable for automated testing, which solves the problems existing in the prior art, avoids the sample transfer step in traditional operations, avoids sample loss and contamination during the transfer process, and ensures the original enrichment of DNA.

[0005] To achieve the above objectives, the present invention provides the following solution: The present invention provides a non-transferable oral cell collection device suitable for automated testing, comprising a support base and a collection card; The support base is provided with a first support part and a second support part, and both the first support part and the second support part have openings. When the first support part and the second support part are in a first working state, there is at least a clearance interval between the first support part and the second support part, which is used to allow the acquisition card to move between the first support part and the second support part. When the first support part and the second support part are in a second working state, at least a portion of the structure of the first support part and the second support part overlaps, and at least a portion of the structure of the two openings overlaps. The acquisition card is connected to the first support or the second support by a first folding structure. When the first folding structure is folded and the first support and the second support are in the second working state, the acquisition card is clamped between the overlapping structures of the first support and the second support. The acquisition card is provided with an acquisition part for acquiring oral cells, and at least part of the acquisition part is located between the two overlapping structures of the openings.

[0006] Optionally, a second folding structure is connected between the first support portion and the second support portion, and after the second folding structure is folded, at least a portion of the first support portion and the second support portion overlap.

[0007] Optionally, at least one set of snap-fit ​​structures is provided between the first support portion and the second support portion to enhance the stability of the first support portion and the second support portion when they are in the second working state, and the snap-fit ​​structures at least avoid the acquisition card.

[0008] Optionally, the snap-fit ​​structure includes a snap-fit ​​groove and a protrusion, and is disposed at the edge positions of the first support portion and the second support portion.

[0009] Optionally, after both the first folding structure and the second folding structure are unfolded, the first support, the second support, and the acquisition card are all in an unfolded state, and the non-transferable oral cell acquisition device suitable for automated testing has an overall strip-shaped structure.

[0010] Optionally, the acquisition card extends along a direction perpendicular to the crease of the first folding structure, and the acquisition part is located at the end of the acquisition card opposite to the first folding structure.

[0011] Optionally, the support base is further provided with an elongated portion and a widened portion. The elongated portion is movably disposed along the length direction of the first support portion and the second support portion and is installed on the first support portion and / or the second support portion. The widened portion is movably disposed along the width direction of the first support portion and the second support portion and is installed on the first support portion and / or the second support portion.

[0012] Optionally, the opening is in the form of a through hole. When the first support and the second support are in the second working state, the two openings are coaxially arranged and overlap as a whole, and the outer peripheral edge of the collection part is located on the outer peripheral side of the opening.

[0013] Optionally, a third support portion is detachably attached to one side of the acquisition card along its thickness direction. The third support portion matches the structure of the acquisition card and is separated from the acquisition card after oral cells are collected.

[0014] Optionally, the first support portion and / or the second support portion are provided with a receiving groove, the receiving groove being located on the side where the first support portion and the second support portion overlap, and the receiving groove being disposed between the opening and the first folding structure, and used to accommodate the acquisition card.

[0015] The present invention achieves the following technical effects compared to the prior art: This application discloses a non-transferable oral cell collection device suitable for automated testing. The collection card is connected to a first support or a second support via a first folding structure, achieving integrated sampling and preservation. Before sampling, the collection card can be unfolded and positioned in a handheld manner with the first and / or second support, facilitating easy insertion into the oral cavity for sample collection. After sampling, the collection card is folded back and fixed between the first and second support, ensuring the sample-laden card directly aligns with the opening, eliminating the need for any transfer tools. This avoids the sample transfer steps required in traditional operations, preventing sample loss and contamination during transfer and ensuring the original enrichment of DNA. Furthermore, the folded integrated device has a neat shape, facilitating subsequent grasping and punching operations. Moreover, this non-transferable oral cell collection device suitable for automated testing, after sample collection, has the collection card clamped between the first and second support, providing a rigid supporting shell. The opening has a collection section with the collected sample, making it suitable not only for subsequent operations but also for subsequent preservation. Attached Figure Description

[0016] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0017] Figure 1 This is an unfolded axonometric view of a non-transferable oral cell collection device suitable for automated testing, as disclosed in this invention. Figure 2 This is a front view of an example of a non-transferable oral cell collection device suitable for automated testing disclosed in this invention, after being unfolded. Figure 3 This is a top view of a non-transferable oral cell collection device suitable for automated testing, as disclosed in this invention, after being stacked. Figure 4 This is a top view of a non-transferable oral cell collection device suitable for automated testing, as disclosed in this invention, after being stacked. Figure 5This is a side view of a second support portion with an extended portion in an example disclosed in this invention; Figure 6 This is a side view of a second support portion with a widened portion, as disclosed in an example of the present invention; Among them, 1-opening, 2-first support part, 3-second support part, 4-collection card, 5-first folding structure, 6-collection part, 7-second folding structure, 8-buckle structure, 9-widening part, 10-lengthening part, 11-top screw structure, 12-paper label clearance hole. Detailed Implementation

[0018] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0019] The purpose of this invention is to provide a non-transferable oral cell collection device suitable for automated testing, which solves the problems existing in the prior art, avoids the sample transfer step in traditional operations, avoids sample loss and contamination during the transfer process, and ensures the original enrichment of DNA.

[0020] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0021] like Figures 1 to 6 As shown, the present invention provides a non-transferable oral cell collection device suitable for automated testing, including a support base and a collection card 4; the support base has a first support portion 2 and a second support portion 3, both of which have openings 1; when the first support portion 2 and the second support portion 3 are in a first working state, there is at least a clearance interval between the first support portion 2 and the second support portion 3, which allows the collection card 4 to move between the first support portion 2 and the second support portion 3; when the first support portion 2 and the second support portion 3 are in a second working state, there is at least a clearance interval between the first support portion 2 and the second support portion 3. The structures are partially overlapped, and at least part of the structures of the two openings 1 overlap; a first folding structure 5 is connected between the acquisition card 4 and the first support part 2 or the second support part 3. After the first folding structure 5 is folded, and when the first support part 2 and the second support part 3 are in the second working state, the acquisition card 4 is clamped between the overlapping structures of the first support part 2 and the second support part 3; the acquisition card 4 is provided with an acquisition part 6 for collecting oral cells. At least part of the structure of the acquisition part 6 is located between the overlapping structures of the two openings 1, so that the acquisition part 6 is clamped by the openings 1 on both sides and the two openings 1 are exposed, which facilitates subsequent drilling work, etc.

[0022] It is understandable that the first support part 2 and the second support part 3 are both made of rigid materials, such as rigid plastics. The rigid plastics can be injection molded from polyethylene or polypropylene, etc., to ensure that when the first support part 2 and the second support part 3 clamp the acquisition card 4 and are in the second working state, the robot arm can apply sufficient clamping force to the first support part 2 and the second support part 3 in the second working state during automated inspection, so as to avoid problems such as unreliable clamping and affecting the inspection work.

[0023] The purpose of the clearance interval is to prevent the acquisition part 6 of the acquisition card 4 from being prematurely touched, which would affect the accuracy of the inspection. In specific applications, for example, after the acquisition card 4 rotates through the first folding structure 5 and adheres to the first support part 2, the second support part 3 maintains a clearance interval with the first support part 2 until it completes the clamping operation of the acquisition card 4, thus preventing the movement of the second support part 3 from touching the acquisition part 6 or the acquisition card 4.

[0024] The first folding structure 5 can be a pin hinge or a membrane hinge. A pin hinge is a pin between the acquisition card 4 and the first support part 2, or between the acquisition card 4 and the second support part 3, so that the acquisition card 4 can rotate. A membrane hinge is a very thin connecting structure between the acquisition card 4 and the first support part 2, or between the acquisition card 4 and the second support part 3, forming a hinge, so that the acquisition card 4 can rotate.

[0025] Based on the above embodiments, a folding part is connected between the acquisition card 4 and the first support part 2 or the second support part 3. A first folding structure 5 is provided on the folding part so that the folding part can be unfolded or folded in half, allowing the acquisition card 4 to rotate as a whole between the first support part 2 and the second support part 3. By providing the folding part, the length of the first support part 2 and the second support part 3 after being stacked can be increased, thereby enabling the corresponding robotic arm to complete the gripping work. Furthermore, without changing the structure of the first support part 2 and the second support part 3, the folding part can be chamfered, that is, the folding part is generally conical and gradually decreases in size towards the acquisition card 4, making it easier to insert into the oral cavity. Without changing the structure of the first support part 2 and the second support part 3, it is possible to meet the requirements of matching the corresponding robotic arm to complete the gripping work.

[0026] Furthermore, based on the above embodiments, the first support portion 2 and the second support portion 3 are at least partially overlapped, so that the acquisition card 4 can be clamped between the overlapping structures of the first support portion 2 and the second support portion 3, ensuring that the acquisition card 4 remains stable as a whole during subsequent operations. Preferably, the first support portion 2 and the second support portion 3 have identical structures and can be fully overlapped in the second working state, so as to ensure the stability of the entire non-transferable oral cell acquisition device suitable for automated testing during the gripping or transfer process of the robotic arm.

[0027] In summary, the non-transferable oral cell collection device suitable for automated testing disclosed in this application connects the collection card 4 to the first support 2 or the second support 3 via a first folding structure 5, achieving integrated sampling and preservation. Before sampling, the collection card 4 can be unfolded and positioned in a handheld manner with the first support 2 and / or the second support 3, facilitating sample collection inside the oral cavity. After sampling, the collection card 4 is folded backwards and fixed between the first support 2 and the second support 3, ensuring that the sample-laden collection card 4 directly aligns with the opening 1, eliminating the need for any transfer tools. This avoids the sample transfer steps in traditional operations, preventing sample loss and contamination during the transfer process and ensuring the original enrichment of DNA. Furthermore, the folded integrated device has a neat shape, facilitating subsequent grasping and punching operations. Furthermore, this non-transferable oral cell collection device suitable for automated testing has a rigid supporting shell after the collection card 4 collects the sample. The collection card 4 is clamped between the first support part 2 and the second support part 3, and the opening 1 has a collection part 6 with the collected sample attached. This not only makes it suitable for subsequent operations, but also for subsequent preservation.

[0028] To enable the switching between the first support part 2 and the second support part 3 in the first working state and the second working state, in some cases, the first support part 2 and the second support part 3 are detachably connected, for example by snap-fit ​​connection or bolt connection. When the first support part 2 and the second support part 3 are in the first working state, they are in a separated state. The acquisition card 4 is connected to the first folding structure 5 on the first support part 2 or the second support part 3. After the acquisition card 4 has collected oral cells, the acquisition card 4 is rotated into place by the first folding structure 5, and the first support part 2 and the second support part 3 are reconnected into place and clamped.

[0029] In other cases, the first support portion 2 and the second support portion 3 remain connected. These connections can be maintained via universal joints, such as miniature universal joints, so that after the data acquisition card 4 is rotated into position via the first folding structure 5, the first support portion 2 or the second support portion 3 can be moved to clamp the data acquisition card 4. Alternatively, the first support portion 2 and the second support portion 3 can be rotatably connected via a rotating connector, such as a shaft, so that after the data acquisition card 4 is rotated into position via the first folding structure 5, the first support portion 2 or the second support portion 3 can be rotated to clamp the data acquisition card 4.

[0030] More preferably, a second folding structure 7 connects the first support part 2 and the second support part 3. After the second folding structure 7 is folded, the first support part 2 and the second support part 3 are in a second working state, with at least a portion of the structures of the first support part 2 and the second support part 3 overlapping to complete the clamping of the data acquisition card 4. The second folding structure 7 can be a pin hinge or a film hinge, etc. A pin hinge is a pin connected to the same end of the first support part 2 and the second support part 3, so that the two can be opened and closed through the pin hinge. A film hinge is formed by injection molding the first support part 2 and the second support part 3 with the same material in one piece, and making the structure very thin at the connection between the two to form a hinge, thus forming a film hinge, so that the first support part 2 and the second support part 3 can be opened and closed through the film hinge.

[0031] Alternatively, a folding part can be connected between the first support part 2 and the second support part 3, and a second folding structure 7 can be provided on the folding part so that the folding part can be unfolded or folded in half, thereby completing the unfolding or overlapping between the first support part 2 and the second support part 3.

[0032] It should be noted that, regardless of the method in which the first support part 2 and the second support part 3 cooperate, when the acquisition card 4 finishes collecting data and rotates, there must be sufficient clearance between the first support part 2 and the second support part 3 to avoid uncontrollable scraping or contact between the first support part 2 or the second support part 3, which needs to be moved, and the acquisition part 6 before clamping the acquisition card 4, which would affect the accuracy of the collected sample.

[0033] In one embodiment, at least one set of latching structures 8 is provided between the first support portion 2 and the second support portion 3 to enhance the stability of the first support portion 2 and the second support portion 3 when they are in the second working state, and the latching structures 8 at least avoid the acquisition card 4.

[0034] The snap-fit ​​structure 8 includes, but is not limited to, a snap-fit ​​groove and a protrusion, and is located at the edges of the first support part 2 and the second support part 3. Through the snap-fit ​​engagement of the groove and the protrusion, the first support part 2 and the second support part 3 can be stably connected together in the second working state, preventing relative movement during subsequent clamping or drilling processes, which would affect the test progress. Positioning the groove and protrusion at the edges of the first support part 2 and the second support part 3 effectively avoids the opening 1, the first folding structure 5, the second folding structure 7, and the data acquisition card 4, ensuring the effectiveness of clamping the data acquisition card 4.

[0035] To facilitate sample collection, after both the first fold structure 5 and the second fold structure 7 are unfolded, the first support part 2, the second support part 3, and the collection card 4 are all in the unfolded state. The non-transferable oral cell collection device suitable for automated testing has an overall strip-shaped structure, which makes it easy for operators to hold and insert into the oral cavity. In a specific example, both the first support part 2 and the second support part 3 are strip-shaped structures and extend along a direction perpendicular to the crease of the second fold structure 7. More preferably, the first fold structure 5 is located at the end of the first support part 2 or the second support part 3 opposite to the second fold structure 7, and its crease is set parallel to the crease of the second fold structure 7 to ensure that the non-transferable oral cell collection device suitable for automated testing is fully unfolded.

[0036] To further facilitate sample collection, the acquisition card 4 extends along the direction perpendicular to the crease of the first folding structure 5, and the acquisition part 6 is located at the end of the acquisition card 4 away from the first folding structure 5.

[0037] In one embodiment, the support base further includes an extension portion 10 and a widening portion 9, which are made of a rigid material, such as rigid plastic, and have a plate-like structure. The extension portion 10 is movably disposed along the length direction of the first support portion 2 and the second support portion 3 and is mounted on the first support portion 2 and / or the second support portion 3; the widening portion 9 is movably disposed along the width direction of the first support portion 2 and the second support portion 3 and is mounted on the first support portion 2 and / or the second support portion 3; by adjusting the extension portion 10 and / or the widening portion 9, the entire non-transferable oral cell collection device suitable for automated testing can be matched with different robotic arms after folding, thereby completing a reliable gripping operation.

[0038] For example, a sandwich layer is provided in both the first support part 2 and the second support part 3. The extended part 10 and the widened part 9 can be movably installed in the sandwich layer. The first support part 2 and the second support part 3 are provided with a first outlet at both ends along the length direction for the extended part 10 to move out or retract, and a second outlet is provided at both ends along the width direction for the widened part 9 to move out or retract.

[0039] It is understandable that both the first outlet and the second outlet are located to accommodate the first folding structure 5 and the second folding structure 7. For example, the first folding structure 5 and the second folding structure 7 are located on one side of the first support part 2 or the second support part 3 along the thickness direction, while the first outlet and the second outlet are located on the other side along the thickness direction, or they can be spaced apart.

[0040] Furthermore, the first support part 2 and the second support part 3 are also provided with a set screw structure 11, etc., so that after the extended part 10 and the widened part 9 are extended or retracted, the set screw structure 11 is tightened to press the extended part 10 and the widened part 9 to keep them in a position.

[0041] In one embodiment, the opening 1 is in the shape of a notch or a through hole. When the opening 1 is in the shape of a notch, it is located at the edge of the first support part 2 and the second support part 3. When the opening 1 is in the shape of a through hole, it is located at the middle of the first support part 2 and the second support part 3.

[0042] Based on the above embodiments, in some cases, the openings 1 on the first support part 2 and the second support part 3 are both notches, and the two openings 1 are located on the same side. When the first support part 2 and the second support part 3 are in the second working state, the two openings 1 partially overlap, or are coaxially arranged and completely overlap, as long as it can ensure that the collecting part 6 can be fully clamped and the drilling work can be completed. In other cases, one opening 1 is notched and the other opening 1 is through-hole. When the first support part 2 and the second support part 3 are in the second working state, the two openings 1 partially overlap, or are coaxially arranged and completely overlap, as long as it can ensure that the collecting part 6 can be fully clamped and the drilling work can be completed. To ensure that the collecting part 6 is fully clamped and can effectively complete the drilling work, both openings 1 are through holes. When the first support part 2 and the second support part 3 are in the second working state, the two openings 1 are coaxially arranged and overlap as a whole. The outer peripheral edge of the collecting part 6 is located on the outer peripheral side of the opening 1, so that the outer peripheral edges of the two openings 1 are clamped on both sides of the collecting part 6, and the stability of the clamping of the collecting part 6 is ensured. Therefore, during the drilling process, since the collecting part 6 has been effectively clamped, the collecting part 6 will not move again, which improves the effectiveness of drilling the collecting part 6.

[0043] In one embodiment, a third support is detachably attached to one side of the acquisition card 4 along its thickness direction. The third support matches the structure of the acquisition card 4 and is separated from the acquisition card 4 after the oral cells are collected. The third support supports the acquisition card 4, increasing the overall structural strength of the acquisition card 4. This allows the operator to hold the support base and directly insert the acquisition card 4 into the oral cavity to collect samples. Furthermore, the acquisition card 4 will not bend during sample collection, ensuring the effectiveness of the collected samples.

[0044] Furthermore, due to the presence of a third support section, the acquisition card 4 can adopt a thinner structure, which is more conducive to subsequent drilling operations.

[0045] The third support component needs to have sufficient structural strength and rigidity to support the data acquisition card 4 in collecting samples. For example, it can be made of rigid plastic. The third support component and the data acquisition card 4 are then bonded together using electrostatic adsorption or capillary action.

[0046] Based on the above implementation, the third support is also provided with a protruding structure that protrudes from both sides of the acquisition card 4 along the width direction of the acquisition card 4, so as to facilitate the operator's grip and facilitate the separation of the acquisition card 4 from the third support.

[0047] In a specific example, the main structure of the third support is attached to the acquisition card 4, and its other part is attached to the first support 2 or the second support 3, so as to avoid the acquisition card 4 being easily folded at the first folding structure 5 during the acquisition process, which would affect the acquisition effect.

[0048] In one embodiment, the first support portion 2 and / or the second support portion 3 are provided with a receiving groove. The receiving groove is located on the side where the first support portion 2 and the second support portion 3 overlap, and is disposed between the opening 1 and the first folding structure 5. The receiving groove is used to accommodate the data acquisition card 4, so that when the data acquisition card 4 is positioned between the first support portion 2 and the second support portion 3, it can be fitted into the receiving groove. This not only positions the data acquisition card 4 but also avoids the problem of easy deformation of the first support portion 2 and the second support portion 3 during the clamping of the data acquisition card 4, thereby ensuring the effectiveness of subsequent inspection work. The thickness of the receiving groove matches the thickness of the data acquisition card 4.

[0049] Furthermore, the first support part 2 and the second support part 3 are also provided with paper label clearance holes 12, and after the first support part 2 and the second support part 3 are overlapped, the two paper label clearance holes 12 are coaxially corresponding. The two paper label clearance holes 12 are used to hold a cleaning card with the same structure as the collection card 4. It should be noted that during DNA testing, after punching a hole in the collection part 6 with a punching needle (e.g., with a diameter of 1.2 mm), the paper containing oral cells will be punched into the 96-well plate for subsequent DNA testing. At this time, there may be residual oral cells on the punching needle, so the head of the punching needle needs to be cleaned. Specifically, since the two paper label clearance holes 12 are used to hold a cleaning card with the same structure as the collection card 4, after punching and sampling, the punching needle will punch the cleaning card again 1-2 times through the paper label clearance holes 12 to clean the head of the punching needle. Then, the part of the cleaning card that was punched out can be removed to complete the cleaning of the punching needle.

[0050] The paper tag used for identification by the detection equipment is held between two paper tag clearance holes 12. The specific paper tag structure is larger than the paper tag clearance holes 12, so that the outer peripheral edge of the paper tag is held between the first support part 2 and the second support part 3, thereby enabling double-sided identification.

[0051] Any adaptive changes made according to actual needs are within the scope of protection of this invention.

[0052] It should be noted that, for those skilled in the art, it is obvious that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0053] Specific examples have been used to illustrate the principles and implementation methods of this invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of this invention. Furthermore, those skilled in the art will recognize that, based on the ideas of this invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of this invention.

Claims

1. A non-transferable oral cell collection device suitable for automated testing, characterized in that, Includes a support base and a data acquisition card; The support base is provided with a first support part and a second support part, and both the first support part and the second support part have openings. When the first support part and the second support part are in a first working state, there is at least a clearance interval between the first support part and the second support part, which is used to allow the acquisition card to move between the first support part and the second support part. When the first support part and the second support part are in a second working state, at least a portion of the structure of the first support part and the second support part overlaps, and at least a portion of the structure of the two openings overlaps. The acquisition card is connected to the first support or the second support by a first folding structure. When the first folding structure is folded and the first support and the second support are in the second working state, the acquisition card is clamped between the overlapping structures of the first support and the second support. The acquisition card is provided with an acquisition part for acquiring oral cells, and at least part of the acquisition part is located between the two overlapping structures of the openings.

2. The non-transferable oral cell collection device suitable for automated testing according to claim 1, characterized in that, A second folding structure is connected between the first support part and the second support part. After the second folding structure is folded, at least a portion of the first support part and the second support part overlap.

3. The non-transferable oral cell collection device suitable for automated testing according to claim 2, characterized in that, At least one set of snap-fit ​​structures is provided between the first support part and the second support part to enhance the stability of the first support part and the second support part when they are in the second working state. The snap-fit ​​structures at least avoid the acquisition card.

4. The non-transferable oral cell collection device suitable for automated testing according to claim 3, characterized in that, The snap-fit ​​structure includes a snap-fit ​​groove and a protrusion, and is located at the edge positions of the first support portion and the second support portion.

5. The non-transferable oral cell collection device suitable for automated testing according to claim 2, characterized in that, After both the first folding structure and the second folding structure are unfolded, the first support, the second support, and the acquisition card are all in the unfolded state, and the non-transferable oral cell acquisition device suitable for automated testing has an overall strip-shaped structure.

6. The non-transferable oral cell collection device suitable for automated testing according to claim 5, characterized in that, The acquisition card extends along a direction perpendicular to the crease of the first folding structure, and the acquisition part is located at the end of the acquisition card opposite to the first folding structure.

7. The non-transferable oral cell collection device suitable for automated testing according to claim 5, characterized in that, The support base is further provided with an extension portion and a widening portion. The extension portion is movably disposed along the length direction of the first support portion and the second support portion, and is installed on the first support portion and / or the second support portion. The widening portion is movably disposed along the width direction of the first support portion and the second support portion, and is installed on the first support portion and / or the second support portion.

8. The non-transferable oral cell collection device suitable for automated testing according to claim 1, characterized in that, The opening is in the shape of a through hole. When the first support and the second support are in the second working state, the two openings are coaxially arranged and overlap as a whole, and the outer peripheral edge of the collection part is located on the outer peripheral side of the opening.

9. The non-transferable oral cell collection device suitable for automated testing according to claim 1, characterized in that, The acquisition card has a third support portion detachably attached to one side along its thickness direction. The third support portion matches the structure of the acquisition card and is separated from the acquisition card after oral cells are collected.

10. The non-transferable oral cell collection device suitable for automated testing according to claim 1, characterized in that, The first support portion and / or the second support portion are provided with a receiving groove, the receiving groove is located on the side where the first support portion and the second support portion overlap, and the receiving groove is disposed between the opening and the first folding structure, and is used to accommodate the acquisition card.

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