A milky white essence based on an acrylic polymer stabilizing system and a method for its preparation

Abstract

The present application provides a kind of based on acrylic polymer stabilizing system milk white essence and its preparation method, simultaneously as emulsifying agent and thickening agent, the acrylic acid ester class / C10-30 alkyl alcohol acrylic ester crosslinking polymer (Pemulen TR-1) in prior art is used as formula auxiliary component, constructs a formula framework extremely simple, and can realize long-term physical and chemical stable milk white essence system, improves the mildness and reliability of formula from the source. By using single, safe, light synthetic oil (caprylic / capric triglyceride) as the only oil phase component, while ensuring the necessary lubricating feeling and active substance dissolving carrier, the system is extremely simple, stable and controllable. Create a mild physical and chemical environment, maximize the protection and maintenance of recombinant collagen and other sensitive bioactive ingredients in the shelf life of chemical integrity and biological efficacy.

Description

Technical Field

[0001] This invention relates to the field of cosmetic formulation stabilization system preparation, specifically to a milky white serum based on an acrylic (ester) polymer stabilization system and its preparation method. Background Technology

[0002] Traditional milky-white serums typically rely on complex combinations of various surfactants or emulsifiers to stabilize the oil-water phase. The introduction of such complex emulsion systems can introduce several problems: First, many emulsifiers, with their molecular structures, can disrupt the lipid bilayer of the stratum corneum, leading to increased transepidermal water loss and triggering or exacerbating dryness, sensitivity, or even inflammation—a key limiting factor in sensitive skin care. Second, for bioengineered active ingredients such as recombinant collagen and peptides, their higher-order structure is fundamental to maintaining bioactivity. Complex emulsifier micelles or liquid crystal structures can bind to these macromolecules through hydrophobic interactions, electrostatic interactions, etc., inducing denaturation, aggregation, or irreversible adsorption, resulting in a sharp decline in activity. With the increasing consumer demand for simplified, gentle, and non-irritating products, developing novel stabilization systems that significantly reduce the types and complexity of emulsifiers has become an important trend.

[0003] To mitigate the risks associated with compound emulsifiers, the industry is exploring the use of water-soluble polymers to construct gel networks for suspending and stabilizing trace amounts of oil or solid particles. Conventional water-based thickeners, such as carbomer and hydroxyethyl cellulose, primarily function to thicken the continuous phase. Oils are physically suspended by using large amounts of conventional water-soluble polymers like carbomer and xanthan gum. Patent 202210730690.0 discloses an emulsifier-free O / W type dispersion system and its preparation method, which uses a dispersion system combining ethyl cellulose and carbomer to replace emulsifiers, reducing skin irritation. These polymers primarily delay oil buoyancy by increasing the viscosity of the aqueous phase, rather than actively capturing and fixing oil droplets. Products with these polymers are prone to problems such as oil buoyancy and uneven appearance. Their stabilization mechanism for the dispersed phase mainly involves increasing the viscosity of the continuous phase to slow particle settling. This mechanism has limited effectiveness in stabilizing oil droplets sufficient to produce a milky white luster. In practice, such formulations either exhibit a transparent / semi-transparent gel state or experience oil buoyancy or polymer shrinkage and water separation within a short period. Adding high doses of polymers to achieve sufficient suspension stability results in a product texture that is sticky, greasy, and lacks fluidity, failing to meet the core requirements of serums for smooth application and a lightweight feel. Studies have shown that the micellar environment in existing complex emulsification systems, along with high-shear and high-temperature emulsification processes, can damage the higher-order structures of biomolecules such as recombinant collagen, leading to their inactivation.

[0004] In summary, the market urgently needs a physically stable system that can achieve a stable appearance of milky white material without relying on emulsifiers. At the same time, this system can also provide a friendly microenvironment for sensitive biomacromolecules such as recombinant collagen, minimizing their degradation and aggregation. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of existing technologies that rely on complex emulsifier systems and are unfriendly to active ingredients, and to provide an essence with a simplified formula, a gentle process, and the ability to simultaneously achieve a stable milky white appearance and a high retention rate of active ingredients, as well as its preparation method.

[0006] To achieve the above objectives, this invention provides a milky white essence based on an acrylate polymer stabilization system. The raw materials, by weight percentage, include: 0.1%–0.5% acrylate / C10-30 alkanol acrylate crosspolymer, 0.02%–3.0% recombinant collagen, 0.02%–3.0% sodium hyaluronate, 0.02%–2.0% tetrahydromethylpyrimidine carboxylic acid, 0.02%–2.0% β-glucan, 1.1%–6.0% preservative system, 0.5%–3.0% single oil, an appropriate amount of alkaline pH adjuster, and purified water to make up the balance. The alkaline pH adjuster is used to adjust the pH of the system to 6.0–6.5 without destroying the active ingredients. The active ingredients are recombinant collagen, sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, and β-glucan.

[0007] Furthermore, the acrylate / C10-30 alkanol acrylate crosspolymer is Pemulen TR-1 or Pemulen TR-2.

[0008] Furthermore, the single oil is one of caprylic / capric triglyceride, isononyl isononanoate, dioctyl carbonate, and octyldodecyl alcohol.

[0009] Furthermore, the alkaline pH adjuster is one of sodium hydroxide, triethanolamine, aminomethylpropanol, and arginine.

[0010] Furthermore, the preservative system is a compound of one of ethylhexylglycerin, capryloyl hydroxamic acid, and p-hydroxyacetophenone with 1,2-pentanediol or 1,2-hexanediol, wherein the mass fraction of ethylhexylglycerin, capryloyl hydroxamic acid, or p-hydroxyacetophenone is 0.1% to 1.0%, and the mass fraction of 1,2-pentanediol or 1,2-hexanediol is 1.0% to 5.0%.

[0011] Furthermore, a method for preparing the aforementioned milky white essence is provided, comprising the following steps: S1. Physically mix the acrylic (ester) / C10-30 alkanol acrylate crosspolymer with octanoic acid / capric acid triglyceride to obtain a primary dispersion system; S2. Sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, β-glucan, 1,2-pentanediol, and p-hydroxyacetophenone are mixed with purified water in a certain proportion to form an aqueous phase of active ingredients. S3. The aqueous phase of the active ingredient is slowly added to the primary dispersion obtained in step S1 under gentle stirring to obtain a mixed system. S4. Slowly add an alkaline pH adjuster to the mixture obtained in step S3 to adjust the pH of the mixture to a precise pH of 6.0–6.5. This ionizes the carboxyl groups on the acrylate / C10-30 alkanol acrylate crosslinking polymer chains, increasing the electrostatic repulsion between chains. This promotes the full extension and crosslinking of the acrylate / C10-30 alkanol acrylate crosslinking polymer chains, forming a dense, robust, and continuous three-dimensional network structure. This three-dimensional network structure permanently captures and fixes the oil droplets formed in step S1 within the three-dimensional network structure. Simultaneously, the viscosity of the mixture increases dramatically, completing the final shaping. S5. Recombinant collagen is added at low temperature to maintain its activity; S6. After filtration to ensure the physical purity of the product, it is finally filled into a container to obtain the final finished essence.

[0012] The beneficial effects of this invention are as follows: 1. Streamlined formula structure: Using a single acrylic (ester) / C10-30 alkanol acrylate crosspolymer (TR1) as the only stable building block, it replaces the multiple emulsifiers and stabilizers that must be compounded in traditional serums, achieving the ultimate simplification of the formula.

[0013] 2. Specific synergistic combination of active ingredients: Recombinant collagen, tetrahydromethylpyrimidine carboxylic acid (ectoin), β-glucan and sodium hyaluronate are combined in specific mass percentages to form a synergistic efficacy matrix for skin barrier repair and soothing, and placed in a streamlined structure.

[0014] 3. Unique “oil-polymer” pre-dispersion: The step of pre-mixing and dispersing caprylic / capric triglyceride (GTCC) with acrylate / C10-30 alkanol acrylate crosspolymer (TR1) forms a primary dispersion.

[0015] 4. The stabilizing mechanism of the milky white appearance through physical network fixation: A dense, cross-linked three-dimensional polymer network formed by neutralization reaction permanently embeds and fixes the oil droplets already formed in the primary dispersion, thereby obtaining a long-term stable milky white appearance, rather than relying on traditional chemical emulsification stabilization. The final product has the combined characteristics of (a) free of emulsifiers other than polymers; (b) exhibiting a stable milky white appearance; (c) having a viscosity and skin feel suitable for dropper application; and (d) maintaining a high retention rate of recombinant collagen and other active ingredients.

[0016] The present invention will now be described in detail with reference to the accompanying drawings and embodiments. Attached Figure Description

[0017] Figure 1 This is a process flow diagram for preparing a milky white serum based on an acrylic (ester) polymer stabilization system. Detailed Implementation

[0018] In existing technologies, acrylate / C10-30 alkanol acrylate crosspolymers (Pemulen TR-1) are commonly used as auxiliary ingredients in formulations. They physically suspend oils by using large amounts of conventional water-soluble polymers such as carbomer and xanthan gum for thickening. These polymers primarily delay oil rising by increasing the viscosity of the aqueous phase, rather than actively capturing and fixing oil droplets. This often results in products with oil rising to the surface and uneven texture. Furthermore, it makes the product sticky, greasy, and lacking in fluidity, failing to meet the core requirements of serums for smooth application and a lightweight feel on the skin.

[0019] To overcome the aforementioned technical bottlenecks, the innovation of this invention lies in discovering and verifying a new technical path: elevating acrylic (ester) polymers from a "supporting role" to a "sole core structural material." Through the combination of their unique physicochemical properties and a specific preparation process, a new system is created within a minimalist formulation framework that can stably present a milky white appearance while providing a friendly environment for a specific bioactive matrix. Existing technologies have not revealed or achieved the unexpected technical effects brought about by this combination of specific components, specific proportions, and specific processes. Overcoming the shortcomings of existing technologies that rely on complex emulsifier systems and are unfriendly to active ingredients, this invention provides a simplified formulation, a gentle process, and an essence that simultaneously achieves a stable milky white appearance and high active ingredient retention rate, along with its preparation method.

[0020] The milky white essence based on an acrylate polymer stabilization system mentioned herein comprises, by weight percentage: 0.1%–0.5% acrylate / C10-30 alkanol acrylate crosspolymer, 0.02%–3.0% recombinant collagen, 0.02%–3.0% sodium hyaluronate, 0.02%–2.0% tetrahydromethylpyrimidine carboxylic acid, 0.02%–2.0% β-glucan, 1.1%–6.0% preservative system, 0.5%–3.0% single oil, an appropriate amount of alkaline pH adjuster, and purified water to make up the balance; wherein, the alkaline pH adjuster is used to adjust the pH of the system to 6.0–6.5 without destroying the active ingredients; the active ingredients are recombinant collagen, sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, and β-glucan.

[0021] The acrylate / C10-30 alkanol acrylate crosslinking polymer is Pemulen TR-1 or Pemulen TR-2 (with a higher degree of crosslinking) or a polymer with similar emulsifying-thickening dual functions; the single oil is one of caprylic / capric triglyceride, isononyl isononanoate, dioctyl carbonate, and octyldodecyl alcohol. The alkaline pH adjuster is one of sodium hydroxide, triethanolamine, aminomethylpropanol, and arginine, provided that it can adjust the pH of the system to 6.0-6.5 without destroying the active ingredients. The preservative system is a compound of one of ethylhexylglycerin, capryloyl hydroxamic acid, and p-hydroxyacetophenone with 1,2-pentanediol or 1,2-hexanediol, wherein the mass fraction of ethylhexylglycerin, capryloyl hydroxamic acid, or p-hydroxyacetophenone is 0.1% to 1.0%, and the mass fraction of 1,2-pentanediol or 1,2-hexanediol is 1.0% to 5.0%.

[0022] 1. The present invention will be further described below through specific embodiments.

[0023] The milky white serum, based on an acrylate (ester) polymer stabilization system, is composed of the following components by weight percentage:

[0024] Simultaneously combined Figure 1 The flowchart shown illustrates the preparation process of a milky white serum based on an acrylate (ester) polymer stabilization system. It clearly illustrates the six core steps in preparing this serum. The core innovation lies in the process path of "first, the polymer and oil are synergistically dispersed to construct a primary stable structure; then, the active ingredients are introduced and protected; and finally, neutralization and stabilization are achieved." The specific execution steps are as follows: S1: This is the initial step. The acrylate / C10-30 alkanol acrylate crosspolymer (TR-1) is physically mixed with all of the octanoic / capric triglycerides (GTCC) in the formulation to obtain a primary dispersion system. This stage aims to achieve initial contact between the polymer particles and the oils to obtain a primary dispersion system. Specifically, the acrylate / C10-30 alkanol acrylate crosspolymer (TR-1) and octanoic / capric triglycerides are placed in a container and premixed evenly. Stirring is started at 300–500 rpm, and homogenization is initiated at 3000–5000 rpm for 1–10 minutes. At this point, the mixture appears milky white. Heating is then started, and stopped when the temperature reaches 65–75°C.

[0025] S2: Sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, β-glucan, 1,2-pentanediol, p-hydroxyacetophenone, and all other water-soluble active ingredients and moisturizing stabilizers are mixed with purified water to dissolve or uniformly disperse, forming an aqueous phase of the active ingredients. The specific process is as follows: 1,2-pentanediol, sodium hyaluronate, and β-glucan are premixed and added to the mixture from step 1, along with tetrahydromethylpyrimidine carboxylic acid and p-hydroxyacetophenone. Homogenization is initiated at 3000–5000 rpm for 1–10 min. After homogenization, the mixture is kept at 65–75°C with stirring for 15–25 min. After this process, homogenization is resumed at 3000–5000 rpm for 1–10 min. Cooling is then initiated until the mixture reaches 35–45°C.

[0026] S3: The aqueous phase of the active ingredient prepared in step S2 is slowly added to the primary dispersion obtained in step S1 under gentle stirring to obtain a mixed system. This operation aims to uniformly introduce the active ingredient into the system.

[0027] S4: This is a crucial step in determining the final system structure. A pH adjuster is slowly added to the mixture from step S3 to precisely adjust the pH of the entire system to 6.0–6.5. Neutralization ionizes the carboxyl groups on the polymer chains, increasing the electrostatic repulsion between chains and promoting full extension and cross-linking of the polymer chains to form a dense, robust, and continuous three-dimensional network structure. This network permanently captures and fixes the oil droplets formed in step S1 within the network, while simultaneously causing a significant increase in the system viscosity, completing the final shaping. Specifically, after cooling, sodium hydroxide solution is added, and the stirring speed is 300–500 rpm for 20–30 minutes. Recombinant collagen is then added, and the stirring speed is 300–500 rpm for 20–30 minutes.

[0028] S5: Recombinant collagen is added at low temperature to maintain its activity.

[0029] S6: After filtration to ensure the physical purity of the product, it is finally filled into dropper containers to obtain the final finished essence.

[0030] In the S6, non-droplet packaging such as vacuum bottles, tubes, and pump bottles can also be used, only requiring adjustment of the final viscosity of the finished essence to the corresponding range.

[0031] Freeze-dried form: The finished serum is freeze-dried to obtain solid freeze-dried tablets / freeze-dried flakes, which are reconstituted with water before use. This form can further extend the shelf life of the active ingredients.

[0032] 2. The following two comparative examples will be used for verification.

[0033] Comparative Example 1 A stable milky-white serum and its preparation method are provided, with the specific steps as follows: Formula: Cetearyl alcohol polyether-20 0.1%~0.5%, glyceryl stearate 0.1%~0.3%, recombinant collagen 0.02%~3.0%, sodium hyaluronate 0.02%~3.0%, tetrahydromethylpyrimidine carboxylic acid 0.02%~2.0%, β-glucan 0.02%~2.0%, 1,2-pentanediol 1.0%~5.0%, caprylic / capric triglyceride 0.5%~3.0%, p-hydroxyacetophenone 0.1%~1.0%, pH adjuster as needed, purified water to make up the balance.

[0034] Process: Accurately weigh the following ingredients: cetearyl alcohol polyether-20, glyceryl stearate, caprylic / capric triglyceride (GTCC), and p-hydroxyacetophenone. Mix these ingredients, heat to 70–80°C, and stir gently until all solids are completely melted and the system is a clear, transparent liquid. Keep warm for later use. In another container, weigh purified water and heat it to 70–80°C. Premix 1,2-pentanediol, β-glucan, and sodium hyaluronate evenly and add them to the purified water, along with tetrahydromethylpyrimidine carboxylic acid and p-hydroxyacetophenone. Keep the mixture warm and stir for 15–25 minutes. Slowly and in a thin stream, add the oil phase (preserved at 70–80°C) to the aqueous phase at the same temperature while stirring at 300–500 rpm. After the oil phase is added, immediately use a homogenizer for high-speed shearing. Homogenization parameters: 3000–5000 rpm, homogenize for 2–3 minutes. The system will immediately change from a turbid liquid to a fine milky white liquid. Begin cooling to 35–45°C. After cooling, add sodium hydroxide solution to adjust the pH to 6.0–6.5. Stir for 20–30 minutes. Then add recombinant collagen and stir for 20–30 minutes.

[0035] Comparative Example 2: The formulation is the same as in Example 1. Process: Weigh purified water into a container. Slowly disperse the acrylate / C10-30 alkanol acrylate crosspolymer (TR-1) in the water, avoiding clumping and ensuring the polymer particles are fully hydrated and swollen. Start stirring and slowly add sodium hydroxide solution dropwise to adjust the pH of the system to 6.0–6.5. At this point, the carboxyl groups on the polymer chains are completely neutralized, and the chains fully extend and cross-link due to charge repulsion, forming a transparent, viscous, and structurally stable homogeneous hydrogel. This gel has high viscoelasticity and a stable three-dimensional network structure. Weigh purified water and heat it to 70–80°C. Premix 1,2-pentanediol, β-glucan, and sodium hyaluronate evenly, add them to the purified water, and simultaneously add tetrahydromethylpyrimidine carboxylic acid and p-hydroxyacetophenone. Keep warm and stir for 15–25 minutes.

[0036] Add caprylic / capric triglycerides and dissolved aqueous phase to the neutralized and stabilized gel. Homogenize the mixture using a high-speed shear homogenizer at 3000–5000 rpm for 2–3 minutes to incorporate the oils and active ingredients into the formed gel network. Begin cooling to 35–45°C. After cooling, add recombinant collagen and stir for 20–30 minutes.

[0037] 3. Experimental effect verification: Comparative tests were conducted on Example 1, Comparative Examples 1 and 2: Test Method: The serums prepared in the examples and comparative examples were aliquoted into sample vials and placed at 45°C for 30 days. Appearance, texture and flowability, centrifugal stability, and recombinant collagen retention were assessed. This example, with a more streamlined formulation, demonstrated significantly better active ingredient protection and system stability than traditional emulsification systems. The failure of Comparative Example 2 proves that the "dispersion first, neutralization later" process sequence is decisive and non-obvious for the successful construction of this system.

[0038]

[0039] 1. Accelerated stability testing was performed on Example 1: 1) Accelerating aging factors

[0040] T AA —Accelerated aging temperature, in degrees Celsius (°C); T RT —Ambient temperature, in degrees Celsius (°C).

[0041] Note: ①Q 10 =An aging factor with a value of 2, which is a 10°C increase or decrease in temperature; ② Accelerated aging temperature, set at 60℃; ③ Ambient temperature, set at 25℃.

[0042] 2) Accelerated aging time AAT = RT / AAF RT – Expected or required actual time; AAF – Accelerating aging factor.

[0043] Test Method: The essence prepared in the example was dispensed into sample bottles and placed at 60°C. The accelerated aging test time was calculated using the Arrhenius formula: (365 × 3) / 2[(60 - 25) / 10] = 96.82 days ≈ 97 days, meaning the accelerated aging time for a 36-month shelf life is 97 days. Therefore, we plan to conduct a 97-day accelerated test, taking samples at 0, 30, 60, and 97 days.

[0044] Stability test data of Example 1

[0045] In summary, the milky white essence based on an acrylic (ester) polymer stabilization system provided by the embodiments of this application exhibits a stable milky white state and is highly stable.

[0046] The reason for this lies in the fact that existing technologies, in order to achieve a stable milky white color, rely on multi-component, high-volume combinations of stabilizers (multiple emulsifiers or large amounts of thickeners). These additional ingredients are potential sources of irritation and compatibility risks. However, Example 1 creatively demonstrates that by controlling the amount of a single, specific acrylate polymer (TR-1) at 0.1%-0.5%, and by preferentially dispersing it in combination with a specific proportion of a single oil (GTCC), a stable milky white system can be independently constructed. This directly replaces the entire complex emulsification-thickening-stabilization system in traditional formulations. This significant simplification of the formula fundamentally reduces the possibility of introducing irritating and incompatible ingredients, perfectly meeting the market's ultimate demand for "simplified skincare" and "gentle and non-irritating" products.

[0047] Furthermore, existing technologies using conventional polymers such as carbomer employ a passive and inefficient stabilization mechanism—simply increasing the viscosity of the aqueous phase to "hold back" the oil droplets. To stabilize sufficiently large oil droplets to produce a milky white appearance, extremely high viscosity is required, inevitably leading to product stickiness, greasiness, and loss of fluidity. Example 1, however, utilizes the unique physicochemical properties of TR-1 polymer: it can disperse oils when unneutralized and rapidly crosslink and solidify after neutralization. Its stabilization mechanism is active and efficient: first, under shear, the oil is "captured" within the loose polymer chains, and then a robust three-dimensional network is instantly formed through a neutralization reaction, "locking" the oil droplets within the network. This "physical cage" effect allows the system to achieve long-term suspension stability far exceeding that of conventional gels at moderate viscosity, thus perfectly balancing the traditionally difficult-to-achieve characteristics of "stable milky white appearance" and "dropper applicability and lightweight feel."

[0048] The micellar environment in existing complex emulsification systems, along with the high-shear and high-temperature emulsification processes, has been shown to disrupt the higher-order structures of biomolecules such as recombinant collagen, leading to their inactivation. Example 1, however, introduces recombinant collagen only after the system network has largely stabilized, completely avoiding the strongly acidic environment and the intense high-shear dispersion process. Furthermore, the resulting polymer network provides spatial isolation for collagen and other macromolecules, reducing the likelihood of intermolecular aggregation.

[0049] As can be seen, the technical solution provided in Example 1 is not a gradual improvement on existing technologies, but rather opens up a completely new technical path by redefining the core stabilizing unit (single polymer TR-1), innovating the stabilization mechanism (physical network capture), and designing a perfectly matched active combination and dedicated process flow. This brings about comprehensive and groundbreaking technological progress.

[0050] It has the following characteristics: 1. Streamlined formula structure: Using a single acrylic (ester) / C10-30 alkanol acrylate crosspolymer (TR1) as the only stable building block, it replaces the multiple emulsifiers and stabilizers that must be compounded in traditional serums, achieving the ultimate simplification of the formula.

[0051] 2. Specific synergistic combination of active ingredients: Recombinant collagen, tetrahydromethylpyrimidine carboxylic acid (ectoin), β-glucan and sodium hyaluronate are combined in specific mass percentages to form a synergistic efficacy matrix for skin barrier repair and soothing, and placed in a streamlined structure.

[0052] 3. Unique “oil-polymer” pre-dispersion: The step of pre-mixing and dispersing caprylic / capric triglyceride (GTCC) with acrylate / C10-30 alkanol acrylate crosspolymer (TR1) forms a primary dispersion.

[0053] 4. The stabilizing mechanism of the milky white appearance through physical network fixation: A dense, cross-linked three-dimensional polymer network formed by neutralization reaction permanently embeds and fixes the oil droplets already formed in the primary dispersion, thereby obtaining a long-term stable milky white appearance, rather than relying on traditional chemical emulsification stabilization. The final product has the combined characteristics of (a) free of emulsifiers other than polymers; (b) exhibiting a stable milky white appearance; (c) having a viscosity and skin feel suitable for dropper application; and (d) maintaining a high retention rate of recombinant collagen and other active ingredients.

[0054] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to any specific implementation. Clearly, many modifications and variations can be made based on the content of this specification. These embodiments have been selected and specifically described in this specification to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. A milky white serum based on an acrylic (ester) polymer stabilization system, characterized in that: The raw materials, by weight percentage, include: 0.1%–0.5% acrylate / C10-30 alkanol acrylate crosspolymer, 0.02%–3.0% recombinant collagen, 0.02%–3.0% sodium hyaluronate, 0.02%–2.0% tetrahydromethylpyrimidine carboxylic acid, 0.02%–2.0% β-glucan, 1.1%–6.0% preservative system, 0.5%–3.0% single oil, appropriate amount of alkaline pH adjuster, and purified water to make up the balance; The alkaline pH adjuster is used to adjust the pH of the system to 6.0-6.5 without destroying the active ingredients; The active ingredients are recombinant collagen, sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, and β-glucan.

2. The milky white essence according to claim 1, characterized in that: The acrylate / C10-30 alkanol acrylate crosslinking polymer is Pemulen TR-1 or Pemulen TR-2.

3. The milky white essence according to claim 1, characterized in that: The single oil is one of caprylic / capric triglyceride, isononyl isononyl carbonate, dioctyl carbonate, and octyl dodecanol.

4. The milky white essence according to claim 1, characterized in that: The alkaline pH adjuster is one of sodium hydroxide, triethanolamine, aminomethylpropanol, and arginine.

5. The milky white essence according to claim 1, characterized in that: The preservative system is a compound of one of ethylhexylglycerin, capryloyl hydroxamic acid and p-hydroxyacetophenone with 1,2-pentanediol or 1,2-hexanediol, wherein the mass fraction of ethylhexylglycerin, capryloyl hydroxamic acid or p-hydroxyacetophenone is 0.1% to 1.0%, and the mass fraction of 1,2-pentanediol or 1,2-hexanediol is 1.0% to 5.0%.

6. A method for preparing a milky white essence according to claim 1, characterized in that, Including the following steps: S1. Physically mix the acrylic (ester) / C10-30 alkanol acrylate crosspolymer with octanoic acid / capric acid triglyceride to obtain a primary dispersion system; S2. Sodium hyaluronate, tetrahydromethylpyrimidine carboxylic acid, β-glucan, 1,2-pentanediol, and p-hydroxyacetophenone are mixed with purified water in a certain proportion to form an aqueous phase of active ingredients. S3. The aqueous phase of the active ingredient is slowly added to the primary dispersion obtained in step S1 under gentle stirring to obtain a mixed system. S4. Slowly add an alkaline pH adjuster to the mixture obtained in step S3 to adjust the pH of the mixture to a precise pH of 6.0–6.

5. This ionizes the carboxyl groups on the acrylate / C10-30 alkanol acrylate crosslinking polymer chains, increasing the electrostatic repulsion between chains. This promotes the full extension and crosslinking of the acrylate / C10-30 alkanol acrylate crosslinking polymer chains, forming a dense, robust, and continuous three-dimensional network structure. This three-dimensional network structure permanently captures and fixes the oil droplets formed in step S1 within the three-dimensional network structure. Simultaneously, the viscosity of the mixture increases dramatically, completing the final shaping. S5. Recombinant collagen is added at low temperature to maintain its activity; S6. After filtration to ensure the physical purity of the product, it is finally filled into a container to obtain the final finished essence.

7. The method for preparing the milky white essence according to claim 6, characterized in that, The process of S1 specifically involves premixing an acrylic (ester) / C10-30 alkanol acrylate crosspolymer with a single oil in a container until homogeneous. Turn on the mixer and set the speed to 300-500 rpm. Start homogenization, homogenization parameters: 3000~5000 rpm, homogenization time 1~10min; At this point, it will appear milky white. Start heating, and stop heating when the temperature reaches 65-75℃.

8. The method for preparing the milky white essence according to claim 7, characterized in that, The process of S2 specifically involves adding 1,2-pentanediol, sodium hyaluronate, and β-glucan to the material prepared in S1 after premixing them evenly, while simultaneously adding tetrahydromethylpyrimidine carboxylic acid and p-hydroxyacetophenone, and then starting homogenization with homogenization parameters of 3000-5000 rpm and a homogenization time of 1-10 min. After homogenization, keep the temperature at 65-75℃ and stir for 15-25 minutes. After the heat preservation and stirring are completed, start the homogenization again. Homogenization parameters: 3000-5000 rpm, homogenization time 1-10 min; Start cooling down to 35-45℃.

9. The method for preparing the milky white essence according to claim 8, characterized in that, The S4 process specifically involves adding an alkaline pH adjuster after cooling is complete, with a stirring speed of 300–500 rpm and a stirring time of 20–30 min. The specific process for S5 is as follows: add recombinant collagen, stir at 300-500 rpm for 20-30 minutes.

10. The method for preparing the milky white essence according to any one of claims 6 to 9, characterized in that, The acrylate / C10-30 alkanol acrylate crosslinker is Pemulen TR-1 or Pemulen TR-2; The caprylic / capric triglyceride can be replaced with one of isononyl isononanoate, dioctyl carbonate and octyldodecyl alcohol; The alkaline pH adjuster is one of sodium hydroxide, triethanolamine, aminomethylpropanol, and arginine; p-Hydroxyacetophenone can be replaced with one of ethylhexylglycerol or capryloyl hydroxamic acid, and 1,2-pentanediol can be replaced with 1,2-hexanediol.

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