External preparation for inhibiting bacteria and inflammation and treating scald and its preparation device

Abstract

The application discloses a kind of external formula for bacteriostatic anti-inflammatory and treating scald and preparation device thereof, including yellow wax 31.2 parts, camphor oil 40.2 parts, pearl powder 14 parts, sanqi powder 14 parts, phenol 0.3 parts, chloramine acid 0.3 parts, the yellow wax is royal jelly wax, the camphor oil is refined sesame oil, the pearl powder is nanoscale pearl powder, the sanqi powder is superfine sanqi powder, the phenol and chloramine acid are all medicinal grade raw materials;The bacteriostatic anti-inflammatory effect of external ointment prepared by the present formula is remarkable, the bacteriostatic rate of staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and candida albicans is all ≥99.5%, and the bacteriostatic ring diameter is better than existing sulfadiazine silver ointment, while having good quick anti-inflammatory effect, accelerates the healing time of Ⅱ degree scald wound, reduces scar formation rate, while greatly reducing local irritation and allergic reaction, far lower than existing western medicine, with good wound healing and safety advantage.

Description

Technical Field

[0001] This invention relates to the field of airtightness testing technology, specifically to a topical formula and preparation device for antibacterial, anti-inflammatory, and burn treatment. Background Technology

[0002] Burns are common accidental injuries in daily life and industrial production. After a burn, the skin tissue is damaged, making it susceptible to bacterial infection, which exacerbates the inflammatory response of the wound, delays the healing process, and in severe cases, may even lead to complications such as systemic infection. Currently, there are many types of medications available for treating burns, mainly including Western medicines and traditional Chinese medicines.

[0003] Western medicine-based burn medications, such as silver sulfadiazine ointment, while possessing some antibacterial effects, may cause local irritation symptoms in some patients, such as pain and itching, and their effect on promoting the healing of deep burns is limited. Traditional Chinese medicine burn medications are mostly based on traditional formulas, and some products suffer from unstable antibacterial effects and long healing periods. Furthermore, some existing burn treatments have complex formulations, cumbersome preparation processes, or high raw material costs, hindering large-scale application. Therefore, we propose a topical formulation and its preparation device for antibacterial, anti-inflammatory, and burn treatment purposes. Summary of the Invention

[0004] The purpose of this invention is to provide a topical formulation and preparation device for antibacterial, anti-inflammatory, and burn treatment, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a topical formula for antibacterial and anti-inflammatory purposes and for treating burns, comprising, by weight, the following raw materials: 31.2 parts beeswax, 40.2 parts sesame oil, 14 parts pearl powder, 14 parts Panax notoginseng powder, 0.3 parts phenol, and 0.3 parts chlorhexidine acetate. The beeswax is royal jelly wax with a purity of 100%; the sesame oil is refined sesame oil with a purity of 100%; the pearl powder is nano-grade pearl powder with a particle size between 100-200 nm and a purity of 100%; the Panax notoginseng powder is ultrafine Panax notoginseng powder with a fineness of not less than 200 mesh and a purity of 100%; the phenol and chlorhexidine acetate are both pharmaceutical-grade raw materials with purities of not less than 98% and 99%, respectively. The system includes a stainless steel reactor. A mixing assembly is positioned at the top center of the reactor. This mixing assembly includes a drive motor, a speed reducer at the motor's output, and a stirring shaft at the speed reducer's output. The outer circumference of the stirring shaft, located inside the reactor, is equipped with irregularly shaped stirring blades and a mixing plate. A detection assembly is also provided on the reactor, comprising a temperature sensor, a vacuum unit, and a pressure unit sequentially mounted on the reactor. A temperature control jacket assembly is located around the reactor's outer circumference, including a jacket and a second temperature sensor located outside the jacket. A dispersion assembly is also provided on the reactor, comprising multiple sets of ultrasonic transducers inside the reactor and an ultrasonic generator located outside the jacket. Multiple sets of mounting ears are evenly distributed circumferentially around the jacket, with a support frame positioned below each set of mounting ears. A central control panel is located on the outer circumference of the jacket above the support frame.

[0006] Preferably, a motor frame is provided at the middle position on the stainless steel reactor, the mounting end of the reducer is installed corresponding to the upper side of the motor frame, the input end of the reducer is installed corresponding to the output end of the drive motor, a coupling is provided between the output end of the reducer and one end of the stirring shaft, a shaft hole is opened at the middle position on the stainless steel reactor, the outer ring of the stirring shaft is installed corresponding to the shaft hole, the mounting ends of the irregular stirring blades and mixing plates are installed corresponding to the outer ring of the stirring shaft located inside the stainless steel reactor, a material leakage shaft bracket is provided at the middle position on the inner wall of the stainless steel reactor, the end of the stirring shaft away from the reducer is installed corresponding to the upper side of the material leakage shaft bracket, and a discharge pipe is provided at the lower part of the stainless steel reactor corresponding to the position of the material leakage shaft bracket; By adopting the above technical solution, the mixing components can be set up to better achieve thorough stirring and mixing during the production and preparation of external pastes in a stainless steel reactor.

[0007] Preferably, the stainless steel reactor is also provided with an oil pipe, a powder pipe, an atomizing nozzle and a viewing window, the vacuum unit includes a vacuum sensor located above the stainless steel reactor and a vacuum pump located on one side above the support frame, the pressure unit includes a pressure sensor located above the stainless steel reactor and a pressure relief valve, and the detection component is electrically connected to the central control panel. By adopting the above technical solutions, the oil pipe, powder pipe, and atomizing nozzle facilitate the operator to add raw materials one by one. The vacuum unit can monitor and adjust the air content in the stainless steel reactor and the paste, ensuring the production quality of the external paste. The pressure unit can monitor and adjust the pressure inside the stainless steel reactor, ensuring the necessary operation for the production and preparation of the external paste in the stainless steel reactor.

[0008] Preferably, the mounting end of the jacket is installed corresponding to the outer ring of the stainless steel reactor, and a gap is left between the jacket and the stainless steel reactor. The mounting end of the second temperature sensor is installed corresponding to the outer side of the jacket. The detection end of the second temperature sensor is located between the jacket and the stainless steel reactor. The second temperature sensor is electrically connected to the central control panel. An oil inlet is provided at the upper position of the outer ring of the jacket, and an oil outlet is provided at the lower position of the jacket. By adopting the above technical solution, the temperature of the stainless steel reactor can be controlled through the temperature control jacket assembly, thereby allowing for better adjustment according to the temperature requirements of different raw materials.

[0009] Preferably, multiple sets of ultrasonic transducers are evenly arranged along the inner wall of the stainless steel reactor. The mounting end of the ultrasonic generator is installed corresponding to one side of the outer ring of the mounting ear. The dispersion component is electrically connected to the central control panel. The mounting end of the mounting ear is installed corresponding to the outer ring of the jacket. The upper side of the support frame is installed corresponding to the lower side of the multiple sets of mounting ears. The mounting end of the central control panel is installed corresponding to the upper side of one set of mounting ears. The central control panel is a PLC controller and has an LCD display function. By adopting the above technical solution, the powdered raw materials can be evenly dispersed through the dispersion component, avoiding the situation of clumping together in the stainless steel reactor.

[0010] Preferably, it includes the following steps: [1] Pretreatment: Crush royal jelly wax into small pieces for later use; sterilize pearl powder and Panax notoginseng powder separately at 121℃ for 20-30 min and cool for later use. [2] Melting wax and mixing oil: Pour sesame oil into the preparation reactor through the oil pipe, start stirring, and stir at a rate of 30-50 r / min. At the same time, control the temperature control jacket assembly through the central control panel to raise the temperature inside the stainless steel reactor to 60-70℃. At this time, temperature sensor one monitors the temperature inside the stainless steel reactor in real time, and temperature sensor two monitors the temperature of the temperature control oil between the jacket and the stainless steel reactor in real time to keep the temperature inside the stainless steel reactor. Add crushed royal jelly wax and continue to stir at 60-70℃ until the royal jelly wax is completely melted to form an oil-wax mixture. [3] Mixing powder: At this time, the temperature sensor detects the temperature of the oil and wax mixture. When the oil and wax mixture cools down to 40-45℃, add sterilized pearl powder and Panax notoginseng powder through the powder tube. Control the drive motor through the central control panel to increase the stirring rate to 80-100r / min and stir for 15-20min. At the same time, the dispersion component works to make the pearl powder and Panax notoginseng powder evenly dispersed to avoid agglomeration and form a paste-like mixture. The operator can view it through the viewing window. [4] Add antibacterial agent: Keep the temperature of the paste mixture at 35-40℃, add phenol and chlorhexidine acetate in sequence through the atomizing nozzle, and continue to stir at a rate of 80-100r / min for 10-15min to obtain the external ointment. At this time, the pressure sensor detects the vacuum degree in the stainless steel reactor and the bubble content of the ointment. When the bubble content of the ointment meets the production requirements, the burn ointment is obtained. By adopting the above technical solution, topical ointments can be produced and prepared quickly.

[0011] Preferably, the application of the topical formulation according to claim 1 in the preparation of a topical medicine for treating second-degree burns accompanied by bacterial or fungal infection; By adopting the above technical solutions, the scope of use of drug formulations can be defined more accurately.

[0012] Compared with the prior art, the beneficial effects of this application are: 1. The topical ointment prepared using this formula has significant antibacterial and anti-inflammatory effects. The antibacterial rate against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans is ≥99.5%, and the diameter of the inhibition ring is superior to that of the existing silver sulfadiazine ointment. At the same time, it has a good and rapid anti-inflammatory effect. 2. It accelerates the healing time of second-degree burns, reduces the scar formation rate, and greatly reduces local irritation and allergic reactions, far lower than existing Western medicines, with good wound healing and safety advantages; 3. The raw material cost is reduced by 20% compared with similar patented formulas, and the preparation cycle is shortened by 30%, making it suitable for use in primary healthcare institutions and homes. At the same time, according to various experimental parameters, this ointment has good stability. After being stored at 25°C for six months, the content of effective ingredients decreases by ≤5%, and the microbial limit still meets the standard.

[0013] 21. By setting up the dispersion component, pearl powder and Panax notoginseng powder can be evenly dispersed and mixed in the topical ointment, thereby ensuring consistent efficacy on each wound, improving the guarantee of efficacy, and avoiding a decrease in antibacterial effect due to component loss. 2. The stirring rate and temperature parameters can be adjusted, making this equipment suitable for other topical ointments containing nanoparticles and volatile components. The preparation process is simple, and it has high versatility and scalability. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the overall structure of the external formulation preparation device of the present invention; Figure 2 This is a schematic diagram of the external formulation preparation device of the present invention from another perspective; Figure 3 This is a partial cross-sectional view of the external formulation preparation device of the present invention.

[0015] In the diagram: 1. Stainless steel reactor; 2. Mixing assembly; 21. Drive motor; 22. Reducer; 23. Stirring shaft; 24. Irregularly shaped stirring blade; 25. Mixing plate; 3. Detection assembly; 31. Temperature sensor one; 32. Vacuum unit; 321. Vacuum sensor; 322. Vacuum pump; 33. Pressure unit; 331. Pressure sensor; 332. Pressure relief valve; 4. Temperature control jacket assembly; 41. Jacket; 42. Temperature sensor two; 43. Oil inlet; 44. Oil outlet; 5. Dispersion assembly; 51. Ultrasonic vibrator; 52. Ultrasonic generator; 6. Support frame; 7. Central control panel; 8. Motor frame; 9. Coupling; 10. Oil pipe; 11. Powder pipe; 12. Atomizing nozzle; 13. Viewing window; 14. Assembly ear; 15. Discharge shaft frame; 16. Discharge pipe. Detailed Implementation

[0016] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0017] Please see Figure 1-3 This invention provides a technical solution: a topical formula for antibacterial and anti-inflammatory purposes and for treating burns. By weight, its raw material composition includes: 31.2 parts beeswax, 40.2 parts sesame oil, 14 parts pearl powder, 14 parts Panax notoginseng powder, 0.3 parts phenol, and 0.3 parts chlorhexidine acetate. The beeswax is royal jelly wax with a purity of 100%; the sesame oil is refined sesame oil with a purity of 100%; the pearl powder is nano-grade pearl powder with a particle size between 100-200 nm and a purity of 100%; the Panax notoginseng powder is ultrafine Panax notoginseng powder with a fineness of not less than 200 mesh and a purity of 100%; both phenol and chlorhexidine acetate are pharmaceutical-grade raw materials with purities of not less than 98% and 99%, respectively. The reactor includes a stainless steel reactor 1, which is equipped with an oil pipe 10, a powder pipe 11, an atomizing nozzle 12, and a viewing window 13. Through holes are provided at the corresponding positions of the oil pipe 10, powder pipe 11, atomizing nozzle 12, and viewing window 13. The mounting ends of the oil pipe 10, powder pipe 11, atomizing nozzle 12, and viewing window 13 are fixedly connected to the stainless steel reactor 1. The oil pipe 10, powder pipe 11, and atomizing nozzle 12 facilitate the operator's individual addition of raw materials. A mixing component 2 is located at the top center of the stainless steel reactor 1. The mixing component 2 includes a drive motor 21, and a reducer 22 is installed at the output end of the drive motor 21. A mixing component 2 is located at the top center of the stainless steel reactor 1. A motor frame 8 is provided, with its mounting end fixedly connected to the upper side of the stainless steel reactor 1. A reducer 22 is also mounted on the upper side of the motor frame 8, with its mounting end fixedly connected to the motor frame 8. The input end of the reducer 22 is mounted correspondingly to the output end of the drive motor 21, and the output end of the drive motor 21 is fixedly connected to the input end of the reducer 22. A stirring shaft 23 is installed at the output end of the reducer 22. A coupling 9 is installed between the output end of the reducer 22 and one end of the stirring shaft 23, with both ends of the coupling 9 fixedly connected to the output end of the reducer 22 and one end of the stirring shaft 23, respectively. The coupling 9 ensures greater stability when the reducer 22 and the stirring shaft 23 are assembled. The stainless steel reactor 1 is located on... A shaft hole is provided in the middle position. The outer ring of the stirring shaft 23 is installed correspondingly to the shaft hole, and the stirring shaft 23 is rotatably connected to the shaft hole. The outer ring of the stirring shaft 23 is tightly fitted to the inner wall of the shaft hole. A shaped stirring blade 24 and a mixing plate 25 are respectively provided on the outer ring of one end of the stirring shaft 23 inside the stainless steel reactor 1. The mounting ends of the shaped stirring blade 24 and the mixing plate 25 are installed correspondingly to the outer ring of the stirring shaft 23 inside the stainless steel reactor 1. The mounting ends of the shaped stirring blade 24 and the mixing plate 25 are fixedly connected to the stirring shaft 23. The shaped stirring blade 24 can rapidly stir the raw material mixture at the bottom of the stainless steel reactor 1, causing it to surge upwards and preventing accumulation at the bottom of the stainless steel reactor 1. The mixing plate 25 can... The raw material mixture in a turbulent state is stirred and mixed to improve the thorough mixing effect between the raw materials. A material leakage shaft bracket 15 is set at the middle position of the inner wall of the stainless steel reactor 1. The mounting end of the material leakage shaft bracket 15 is fixedly connected to the bottom of the inner wall of the stainless steel reactor 1. The end of the stirring shaft 23 away from the reducer 22 is installed corresponding to the upper side of the material leakage shaft bracket 15. The stirring shaft 23 and the material leakage shaft bracket 15 are rotatably connected. The setting of the material leakage shaft bracket 15 can make the stirring shaft 23 more stable when it is in the assembled state, and at the same time, it can avoid interfering with the material feeding operation. A discharge pipe 16 is set at the lower part of the stainless steel reactor 1 corresponding to the position of the material leakage shaft bracket 15. The mounting end of the discharge pipe 16 is fixedly connected to the stainless steel reactor 1. A solenoid valve is installed in the discharge pipe 16.The discharge pipe 16 allows for the discharge of the prepared topical ointment, while the mixing component 2 ensures thorough mixing during the production of the ointment using the stainless steel reactor 1, guaranteeing uniform mixing of the raw materials and thus ensuring the medicinal efficacy of the ointment. A detection assembly 3 is installed on the stainless steel reactor 1. The detection assembly 3 includes a temperature sensor 31, a vacuum unit 32, and a pressure unit 33, all sequentially installed on the stainless steel reactor 1. The mounting end of the temperature sensor 31 is fixedly connected to the stainless steel reactor 1, and its detection end is located inside the reactor 1. The temperature sensor 31 is configured to monitor the stability within the reactor 1 in real time. The vacuum unit 32 includes a vacuum sensor 321 located above the reactor 1 and a vacuum pump 322 located on one side above the support frame 6. The mounting end of the vacuum sensor 321 is fixedly connected to the reactor 1, and its detection end is located inside the reactor 1. The vacuum sensor 321 is configured to monitor the gas content within the reactor 1 and the ointment. The mounting end of the vacuum pump 322 is fixedly connected to the support frame 6. The device 321 is electrically connected to the vacuum pump 322. The vacuum pump 322 can adjust the air content in the stainless steel reactor 1. The vacuum unit 32 can monitor and adjust the air content in the stainless steel reactor 1 and the paste to ensure the production quality of the external paste. The pressure unit 33 includes a pressure sensor 331 and a pressure relief valve 332 located above the stainless steel reactor 1. The mounting ends of the pressure sensor 331 and the pressure relief valve 332 are fixedly connected to the stainless steel reactor 1. The detection end of the pressure sensor 331 is located inside the stainless steel reactor 1. The pressure sensor 331 can monitor the pressure inside the stainless steel reactor 1 in real time. The pressure relief valve 332 can relieve the pressure in the stainless steel reactor 1. The pressure unit 33 monitors and adjusts the pressure inside the stainless steel reactor 1 to ensure the required operation when the external paste is produced and prepared in the stainless steel reactor 1. A temperature control jacket assembly 4 is provided on the outer ring of the stainless steel reactor 1. The temperature control jacket assembly 4 includes a jacket 41 and a second temperature sensor 42 located outside the jacket 41. The mounting end of the jacket 41 is installed corresponding to the outer ring of the stainless steel reactor 1 and is fixedly connected to the stainless steel reactor 1, with a gap between the jacket 41 and the stainless steel reactor 1. The mounting end of the second temperature sensor 42 is installed corresponding to the outer ring of the jacket 41 and is fixedly connected to the jacket 41. The detection end of the second temperature sensor 42 is located between the jacket 41 and the stainless steel reactor 1. The arrangement of 42 allows for real-time monitoring of the temperature of the temperature control oil between the jacket 41 and the stainless steel reactor 1. An oil inlet 43 is provided at the upper position of the outer ring, and an oil outlet 44 is provided at the lower position of the jacket 41. The installation ends of the oil inlet 43 and the oil outlet 44 are fixedly connected to the jacket 41. The oil inlet 43 allows the temperature control oil to enter the gap between the jacket 41 and the stainless steel reactor 1, and the oil outlet 44 allows the temperature control oil in the gap to be discharged. The oil inlet 43 and the oil outlet 44, together with the external circulating oil pump and oil tank, can make the temperature control oil circulate, thereby enabling better and more precise control of the internal temperature of the stainless steel reactor 1. The temperature of the stainless steel reactor 1 is controlled by the temperature control jacket assembly 4, so that the temperature can be more accurately adjusted according to the temperature required by different raw materials. The stainless steel reactor 1 is also equipped with a dispersion component 5, which includes multiple sets of ultrasonic transducers 51 located inside the stainless steel reactor 1 and an ultrasonic generator 52 located outside the jacket 41. The multiple sets of ultrasonic transducers 51 are evenly arranged along the inner wall of the stainless steel reactor 1. The mounting end of the ultrasonic transducer 51 is fixedly connected to the inner wall of the stainless steel reactor 1. The mounting end of the ultrasonic generator 52 is installed corresponding to one side of the outer ring of the mounting ear 14. The mounting end of the ultrasonic generator 52 is fixedly connected to the mounting ear 14. The ultrasonic generator 52, together with the multiple sets of ultrasonic transducers 51, can evenly disperse the powdered raw materials and avoid the situation of accumulating and clumping inside the stainless steel reactor 1. Multiple sets of mounting ears 14 are evenly arranged circumferentially around the outer periphery of the jacket 41. The mounting ends of the mounting ears 14 are installed corresponding to the outer ring of the jacket 41, and the mounting ears 14 are fixedly connected to the jacket 41. A support frame 6 is provided below the multiple sets of mounting ears 14, and the upper side of the support frame 6 is installed corresponding to the lower side of the multiple sets of mounting ears 14. The support frame 6 is fixedly connected to the multiple sets of mounting ears 14. The support frame 6 can provide stable support for the temperature control jacket assembly 4 and the stainless steel reactor 1, thereby making it more stable for the operator to prepare external pastes when using this equipment. The outer ring of the jacket 41 is located on the upper side of the support frame 6. A central control panel 7 is provided, with its mounting end corresponding to the upper side of a set of mounting ears 14. The mounting end of the central control panel 7 is fixedly connected to the mounting ears 14. The central control panel 7 is a PLC controller with an LCD display function. The detection component 3 is electrically connected to the central control panel 7, the temperature sensor 42 is electrically connected to the central control panel 7, and the dispersion component 5 is electrically connected to the central control panel 7. The central control panel 7 allows the operator to accurately control and set parameters of the device according to the requirements of different raw materials, thereby enabling better production and preparation of burn ointments with antibacterial and anti-inflammatory effects. The application of the topical formulation according to claim 1 in the preparation of a topical medicine for treating second-degree burns accompanied by bacterial or fungal infections also has good antibacterial and anti-inflammatory effects on burns, frostbite, scalds, bedsores, diabetic foot, unsealed wounds, and various intractable diseases, osteomyelitis, etc.

[0018] The implementation principle of this application is as follows: [1], Pre-treatment stage, PLC controller automatically links: royal jelly wax is broken into small pieces for later use; pearl powder and Panax notoginseng powder are sterilized separately, sterilization temperature is 121℃, sterilization time is 20-30min, and then cooled for later use; [2] Melting wax and mixing oil: Pour sesame oil into the preparation reaction vessel through the oil pipe 10, start stirring, and the stirring rate is 30-50 r / min. At the same time, control the temperature control jacket assembly 4 through the central control panel 7 to raise the temperature inside the stainless steel reaction vessel 1 to 60-70℃. At this time, temperature sensor 1 31 monitors the temperature inside the stainless steel reaction vessel 1 in real time, and temperature sensor 2 42 monitors the temperature of the temperature control oil between the jacket 41 and the stainless steel reaction vessel 1 in real time, so that the temperature inside the stainless steel reaction vessel 1 is maintained. Add the crushed royal jelly wax, continue to maintain the temperature at 60-70℃ and stir until the royal jelly wax is completely melted to form an oil-wax mixture. [3] Mixing powder: At this time, the temperature sensor 31 detects the temperature of the oil and wax mixture. When the oil and wax mixture cools down to 40-45℃, the sterilized pearl powder and Panax notoginseng powder are added through the powder tube 11. The drive motor 21 is controlled through the central control panel 7 to increase the stirring rate to 80-100r / min and stir for 15-20min. At the same time, the dispersion component 5 works to make the pearl powder and Panax notoginseng powder evenly dispersed to avoid agglomeration and form a paste-like mixture. The operator can view it through the viewing window 13. [4] Add antibacterial agent: Keep the temperature of the paste mixture at 35-40℃, add phenol and chlorhexidine acetate sequentially through the atomizing nozzle 12, and continue to stir at a rate of 80-100r / min for 10-15min to obtain the external ointment. At this time, the pressure sensor 331 detects the vacuum degree in the stainless steel reactor 1 and the bubble content of the ointment. When the bubble content of the ointment meets the production requirements, the burn ointment is obtained.

[0019] Experimental data: Raw material specifications: Yellow wax: royal jelly wax, 312kg; Sesame oil: Refined sesame oil, 402 kg; Pearl powder: Nano grade, 140kg; Panax notoginseng powder: ultrafine grade, 140kg; Phenol: Pharmaceutical grade, 3kg; Chlorhexidine acetate: pharmaceutical grade, 3 kg; Device parameter settings: The reactor was heated to 65℃ (sesame oil), and the beeswax was stirred for 10 minutes. It was then degassed under vacuum at -0.09MPa for 6 minutes. The temperature was then lowered to 43℃, and the powder was stirred for 18 minutes. The antibacterial agent was added at 38℃. Finished product test results: Physicochemical properties: viscosity 6480 mPa·s, pH 6.2, moisture ≤0.5%; Efficacy indicators: Staphylococcus aureus inhibition rate of 99.8%, second-degree burn healing time of 12.1 days; Sterility indicator: Colony count 3 CFU / g, which meets the standard.

[0020] Effect verification experiment: Comparative test of antibacterial and anti-inflammatory effects Experimental subjects: Commonly known clinical pathogens (Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans); Experimental group: the formula of this invention; Control group 1: silver sulfadiazine ointment; Control group 2: traditional Chinese medicine burn ointment; Test methods: inhibition zone test (GB / T 21703-2008) and determination of minimum inhibitory concentration (MIC); Experimental results: | Indicators | Formula of this invention | Control group 1 | Control group 2 | | Staphylococcus aureus inhibition zone (mm) | 18.5±0.5 | 15.2±0.3 | 13.1±0.4 | | Pseudomonas aeruginosa MIC (μg / mL) | 8 | 16 | 32 | | Candida albicans inhibition rate (%) | 99.6 | 85.2 | 90.5 | | Time for wound redness and swelling to subside (h) | 24±6 | 48±10 | 36±8 | Conclusion: The formula of this invention has a broader antibacterial spectrum and a faster anti-inflammatory speed.

[0021] The above specific embodiments are merely preferred embodiments of the present invention. Based on the technical solutions of the present invention and the relevant teachings of the above embodiments, those skilled in the art can make various alternative improvements and combinations to the above specific embodiments.

Claims

1. A topical formulation for antibacterial and anti-inflammatory purposes and for treating burns, comprising, by weight, the following raw materials: The composition includes 31.2 parts beeswax, 40.2 parts sesame oil, 14 parts pearl powder, 14 parts Panax notoginseng powder, 0.3 parts phenol, and 0.3 parts chlorhexidine acetate. The beeswax is royal jelly wax with a purity of 100%. The sesame oil is refined sesame oil with a purity of 100%. The pearl powder is nano-grade pearl powder with a particle size between 100-200 nm and a purity of 100%. The Panax notoginseng powder is ultrafine Panax notoginseng powder with a fineness of not less than 200 mesh and a purity of 100%. The phenol and chlorhexidine acetate are both pharmaceutical-grade raw materials with purities of not less than 98% and 99%, respectively.

2. A preparation apparatus adapted to the formulation of claim 1, characterized in that: The reactor includes a stainless steel reactor (1), and a mixing component (2) is provided at the middle position above the reactor (1). The mixing component (2) includes a drive motor (21), and a reducer (22) is provided at the output end of the drive motor (21). A stirring shaft (23) is provided at the output end of the reducer (22). The outer ring of the stirring shaft (23) located inside the stainless steel reactor (1) is provided with a shaped stirring blade (24) and a mixing plate (25). A detection component (3) is provided on the stainless steel reactor (1). The detection component (3) includes a temperature sensor (31), a vacuum unit (32), and a pressure unit (33) installed sequentially on the stainless steel reactor (1). The stainless steel reactor (1) is provided with a temperature control jacket assembly (4) on its outer ring. The temperature control jacket assembly (4) includes a jacket (41) and a temperature sensor (42) located outside the jacket (41). The stainless steel reactor (1) is also provided with a dispersion assembly (5). The dispersion assembly (5) includes multiple sets of ultrasonic transducers (51) located inside the stainless steel reactor (1) and an ultrasonic generator (52) located outside the jacket (41). Multiple sets of mounting ears (14) are uniformly arranged circumferentially on the outer periphery of the jacket (41). A support frame (6) is provided below the multiple sets of mounting ears (14). A central control panel (7) is provided on the side of the outer ring of the jacket (41) above the support frame (6).

3. The preparation apparatus according to claim 2, characterized in that: A motor frame (8) is installed at the middle position on the stainless steel reactor (1). The mounting end of the reducer (22) is installed corresponding to the upper side of the motor frame (8). The input end of the reducer (22) is installed corresponding to the output end of the drive motor (21). A coupling (9) is provided between the output end of the reducer (22) and one end of the stirring shaft (23). A shaft hole is opened at the middle position on the stainless steel reactor (1). The outer ring of the stirring shaft (23) corresponds to the shaft hole. The installation ends of the irregular stirring blades (24) and mixing plates (25) are installed corresponding to the outer ring of one end of the stirring shaft (23) located inside the stainless steel reactor (1). A material leakage shaft bracket (15) is provided at the middle position of the inner wall of the stainless steel reactor (1). The end of the stirring shaft (23) away from the reducer (22) is installed corresponding to the upper side of the material leakage shaft bracket (15). A discharge pipe (16) is provided at the lower part of the stainless steel reactor (1) corresponding to the position of the material leakage shaft bracket (15).

4. The preparation apparatus according to claim 2, characterized in that: The stainless steel reactor (1) is also equipped with an oil pipe (10), a powder pipe (11), an atomizing nozzle (12) and a viewing window (13). The vacuum unit (32) includes a vacuum sensor (321) located above the stainless steel reactor (1) and a vacuum pump (322) located on one side above the support frame (6). The pressure unit (33) includes a pressure sensor (331) located above the stainless steel reactor (1) and a pressure relief valve (332). The detection component (3) is electrically connected to the central control panel (7).

5. The preparation apparatus according to claim 2, characterized in that: The mounting end of the jacket (41) is installed corresponding to the outer ring of the stainless steel reactor (1). There is a gap between the jacket (41) and the stainless steel reactor (1). The mounting end of the second temperature sensor (42) is installed corresponding to the outer side of the jacket (41). The detection end of the second temperature sensor (42) is located between the jacket (41) and the stainless steel reactor (1). The second temperature sensor (42) is electrically connected to the central control panel (7). An oil inlet (43) is provided at the upper position of the outer ring of the jacket (41). An oil outlet (44) is provided at the lower position of the jacket (41).

6. The preparation apparatus according to claim 2, characterized in that: Multiple sets of ultrasonic transducers (51) are evenly arranged along the inner wall of the stainless steel reactor (1). The mounting end of the ultrasonic generator (52) is installed corresponding to one side of the outer ring of the mounting ear (14). The dispersion component (5) is electrically connected to the central control panel (7). The mounting end of the mounting ear (14) is installed corresponding to the outer ring of the jacket (41). The upper side of the support frame (6) is installed corresponding to the lower side of the multiple sets of mounting ears (14). The mounting end of the central control panel (7) is installed corresponding to the upper side of one set of mounting ears (14). The central control panel (7) is a PLC controller and has an LCD display function.

7. A method for preparing a topical formulation for antibacterial, anti-inflammatory, and burn treatment according to claims 1-6, characterized in that: Includes the following steps: [1] Pretreatment: Crush royal jelly wax into small pieces for later use; sterilize pearl powder and Panax notoginseng powder separately at 121℃ for 20-30 min and cool for later use. [2] Melting wax and mixing oil: Pour sesame oil into the preparation reactor through the oil pipe (10), start stirring, and the stirring rate is 30-50 r / min. At the same time, control the temperature control jacket assembly (4) through the central control panel (7) to raise the temperature inside the stainless steel reactor (1) to 60-70℃. At this time, temperature sensor one (31) monitors the temperature inside the stainless steel reactor (1) in real time, and temperature sensor two (42) monitors the temperature of the temperature control oil between the jacket (41) and the stainless steel reactor (1) in real time, so that the temperature inside the stainless steel reactor (1) is maintained. Add crushed royal jelly wax, continue to maintain the temperature at 60-70℃ and stir until the royal jelly wax is completely melted to form an oil-wax mixture. [3] Mixing powder: At this time, temperature sensor 1 (31) detects the temperature of the oil and wax mixture. When the oil and wax mixture cools down to 40-45℃, add sterilized pearl powder and Panax notoginseng powder through the powder tube (11). Control the drive motor (21) through the central control panel (7) to increase the stirring rate to 80-100r / min and stir for 15-20min. At the same time, the dispersion component (5) works to make the pearl powder and Panax notoginseng powder evenly dispersed to avoid agglomeration and form a paste mixture. The operator can view it through the viewing window (13). [4] Add antibacterial agent: Keep the temperature of the paste mixture at 35-40℃, add phenol and chlorhexidine acetate sequentially through the atomizing nozzle (12), and continue to stir at a rate of 80-100r / min for 10-15min to obtain the external ointment. At this time, the pressure sensor (331) detects the vacuum degree in the stainless steel reactor (1) and the bubble content of the ointment. When the bubble content of the ointment meets the production requirements, the burn ointment is obtained.

8. The use of the topical formulation according to claim 1 in the preparation of a topical medicine for treating second-degree burns accompanied by bacterial or fungal infection.

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