A traditional Chinese medicine composition for treating rhinitis

Abstract

The application discloses a traditional Chinese medicine composition for treating rhinitis and belongs to the technical field of traditional Chinese medicine compositions, which is prepared from magnolia, xanthium sibiricum, eupatorium fortunei, ligusticum sinense, chuanxiong rhizome, houttuynia cordata, baizhi, platycodon grandiflorum, dried tangerine or orange peel, wild chrysanthemum and agastache rugosa. In the application, magnolia and xanthium sibiricum are monarch drugs, and are matched with eupatorium fortunei to directly pass through the orifices of the body and rapidly relieve nasal congestion; houttuynia cordata and wild chrysanthemum clear heat and resolve toxins, reduce the performance of inflammatory factors in the nasal cavity, chuanxiong rhizome, baizhi and ligusticum sinense promote blood circulation and dispel wind, go up to the head and improve local microcirculation and headache; platycodon grandiflorum carries drugs to go up, dried tangerine or orange peel and agastache rugosa eliminate dampness and harmonize the center, can be acrid and dispersing, warm and unblock, rapidly relieve the congestion and edema of the nasal mucosa, restore the ventilation function of the nasal cavity, achieve the effects of unblocking the orifices of the body, resisting inflammation and strengthening the body resistance.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine composition technology, specifically a traditional Chinese medicine composition for treating rhinitis. Background Technology

[0002] Rhinitis is a common respiratory disease affecting a large population worldwide. Rhinitis typically refers to inflammation of the nasal mucosa and can be classified into allergic rhinitis and non-allergic rhinitis based on its cause. Common symptoms include nasal congestion, sneezing, runny nose, and nasal itching. Allergic rhinitis is often triggered by allergens such as pollen, dust mites, and pet dander, and is especially common during seasonal changes.

[0003] Not only does it affect the patient's quality of life, but it can also lead to complications such as otitis media and asthma. Although modern medicine has a variety of drugs and surgical methods to relieve symptoms, relapse is common during treatment. Current treatments for rhinitis are mainly based on chemical drugs: oral or topical antihistamines, glucocorticoids, and decongestants can relieve nasal congestion, runny nose, and sneezing in the short term, but there are rebound effects after stopping the medication, drug-induced rhinitis, drowsiness, and long-term hormone side effects. Immunotherapy has a long cycle and high cost, and its efficacy against allergens other than dust mites is limited. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine composition for treating rhinitis, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a combination of Magnolia biondii, Xanthium sibiricum, Centipeda minima, Ligusticum striatum, Ligusticum chuanxiong, Houttuynia cordata, Angelica dahurica, Platycodon grandiflorus, Citrus reticulata peel, Chrysanthemum indicum, and Pogostemon cablin. Magnolia flower disperses wind-cold and clears nasal passages, making it an essential medicine for sinusitis. Its volatile oil contains components such as α-pinene and β-pinene, which can quickly relieve nasal congestion and edema and restore nasal ventilation. Xanthium sibiricum dispels wind and dampness, clears the nasal passages and relieves pain. It helps Magnolia biondii enhance its ability to clear the nasal passages. The xanthogen glycosides and fatty oils it contains can inhibit histamine release and reduce sneezing and runny nose caused by allergic rhinitis. Ligusticum striatum dispels wind and cold, relieves pain, and guides the medicine upward to the head and face. The ligustilide and coumarin it contains can block the synthesis of prostaglandins and quickly relieve nasal headaches. Its volatile components can increase nasal blood flow and increase the local drug concentration. Chuanxiong (Ligusticum striatum) invigorates blood circulation, dispels wind and relieves pain. It improves local blood circulation in the nasal cavity, reduces blood viscosity, and inhibits platelet aggregation, thereby alleviating nasal mucosal congestion and shortening the duration of nasal congestion. Houttuynia cordata has the effects of clearing heat and detoxifying, eliminating carbuncles and draining pus, inhibiting nasal inflammatory response, and its houttuynin and decanoyl acetaldehyde have a strong inhibitory and bactericidal effect on nasal pathogens such as Staphylococcus aureus and Haemophilus influenzae, and reduce inflammatory exudation. Angelica dahurica dispels wind and dampness, reduces swelling and drains pus, enhances the ability to open nasal passages and relieve pain, inhibits the formation of leukotrienes, and reduces nasal mucosal hyperreactivity. Platycodon grandiflorus can clear the lungs and soothe the throat, and carry the medicine upward so that the medicinal power can directly reach the nasal cavity. Platycodon grandiflorus saponins can reflexively increase the discharge of nasal secretions by stimulating the bronchial mucosa. Dried tangerine peel can regulate qi and dry dampness, harmonize the spleen and stomach, and resolve the source of dampness and turbidity. The hesperidin and volatile oil it contains can regulate qi and reduce the production of phlegm and turbidity. Wild chrysanthemum has the effects of clearing heat and detoxifying, dispelling wind and calming the liver, and inhibiting allergen stimulation. Its luteolin and luteolin can stabilize mast cell membranes and reduce IgE-mediated histamine release, and have a significant relieving effect on allergic rhinitis induced by pollen and dust mites. Patchouli, with its aromatic properties, clears away turbidity, harmonizes the stomach and stops vomiting, and harmonizes other herbs, preventing their pungent and dispersing effects from depleting vital energy. Patchouli alcohol and volatile oil can correct the pH value of nasal mucus and inhibit the growth of putrefactive bacteria; its spleen-invigorating and stomach-harmonizing effects ensure that the entire formula attacks pathogens without harming the body's vital energy, making it suitable for long-term use.

[0006] As a further preferred embodiment of this technical solution: the traditional Chinese medicine composition comprises the following components in parts by weight: Magnolia biondii 5-15 parts, Xanthium sibiricum 3-12 parts, Centipeda minima 3-12 parts, Ligusticum striatum 3-12 parts, Ligusticum chuanxiong 3-12 parts, Houttuynia cordata 10-20 parts, Angelica dahurica 3-12 parts, Platycodon grandiflorus 3-12 parts, Citrus reticulata 3-12 parts, Chrysanthemum indicum 3-12 parts, and Pogostemon cablin 3-12 parts; As a further preferred embodiment of this technical solution: the traditional Chinese medicine composition comprises the following components in parts by weight: Magnolia biondii 8-12 parts, Xanthium sibiricum 8-11 parts, Centipeda minima 5-10 parts, Ligusticum striatum 5-10 parts, Ligusticum chuanxiong 5-10 parts, Houttuynia cordata 10-18 parts, Angelica dahurica 5-10 parts, Platycodon grandiflorus 5-10 parts, Citrus reticulata 5-10 parts, Chrysanthemum indicum 5-10 parts, and Pogostemon cablin 5-10 parts; As a further preferred embodiment of this technical solution: the traditional Chinese medicine composition comprises the following components in parts by weight: Magnolia biondii 9-11 parts, Xanthium sibiricum 9-11 parts, Centipeda minima 7-9 parts, Ligusticum striatum 7-9 parts, Ligusticum chuanxiong 7-9 parts, Houttuynia cordata 14-16 parts, Angelica dahurica 7-9 parts, Platycodon grandiflorus 7-9 parts, Citrus reticulata 7-9 parts, Chrysanthemum indicum 7-9 parts, and Pogostemon cablin 7-9 parts; As a further preferred option of this technical solution: 10 parts Magnolia biondii, 10 parts Xanthium sibiricum, 8 parts Centipeda minima, 8 parts Ligusticum striatum, 8 parts Ligusticum chuanxiong, 15 parts Houttuynia cordata, 8 parts Angelica dahurica, 8 parts Platycodon grandiflorus, 8 parts Citrus reticulata, 8 parts Chrysanthemum indicum, and 8 parts Pogostemon cablin. As a further preferred embodiment of this technical solution: the traditional Chinese medicine composition is used in the treatment of acute rhinitis, chronic rhinitis, and allergic rhinitis; As a further preferred embodiment of this technical solution: the traditional Chinese medicine composition is mixed with a binder to form pills; As a further preferred embodiment of this technical solution: the adhesive is honey or water; As a further preferred embodiment of this technical solution, the mass of the pellet is 0.1-0.3g.

[0007] Compared with the prior art, the beneficial effects of the present invention are: In this invention, Magnolia biondii and Xanthium sibiricum are the principal herbs, and Centipeda minima is added to directly open the nasal passages and quickly relieve nasal congestion; Houttuynia cordata and Chrysanthemum indicum clear heat and detoxify, reducing the expression of inflammatory factors in the nasal cavity; Ligusticum chuanxiong, Angelica dahurica, and Ligusticum striatum invigorate blood and dispel wind, ascending to the head to improve local microcirculation and relieve headache; Platycodon grandiflorus carries the medicine upward, while Citrus reticulata peel and Pogostemon cablin resolve dampness and harmonize the middle jiao, which can disperse and warm, quickly relieve congestion and edema of the nasal mucosa, restore the nasal cavity's ventilation function, and achieve the effects of clearing the nasal passages, anti-inflammation, and strengthening the body's resistance. Detailed Implementation

[0008] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0009] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those familiar to those skilled in the art. Furthermore, any methods and materials similar to or equivalent to those described herein may be applied to this invention. The preferred embodiments and materials described herein are for illustrative purposes only and do not limit the scope of this application.

[0010] Example 1 A traditional Chinese medicine composition for treating rhinitis The traditional Chinese medicine composition comprises the following components in parts by weight: 10 parts Magnolia biondii, 10 parts Xanthium sibiricum, 8 parts Centipeda minima, 8 parts Ligusticum striatum, 8 parts Ligusticum chuanxiong, 15 parts Houttuynia cordata, 8 parts Angelica dahurica, 8 parts Platycodon grandiflorus, 8 parts Citrus reticulata peel, 8 parts Chrysanthemum indicum, and 8 parts Pogostemon cablin.

[0011] Example 2 A traditional Chinese medicine composition for treating rhinitis The traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts Magnolia biondii, 12 parts Xanthium sibiricum, 12 parts Centipeda minima, 12 parts Ligusticum striatum, 12 parts Ligusticum chuanxiong, 20 parts Houttuynia cordata, 12 parts Angelica dahurica, 12 parts Platycodon grandiflorus, 12 parts Citrus reticulata peel, 12 parts Chrysanthemum indicum, and 12 parts Pogostemon cablin.

[0012] Example 3 A traditional Chinese medicine composition for treating rhinitis The traditional Chinese medicine composition comprises the following components in parts by weight: 10 parts Magnolia biondii, 7 parts Xanthium sibiricum, 7 parts Centipeda minima, 7 parts Ligusticum striatum, 7 parts Ligusticum chuanxiong, 15 parts Houttuynia cordata, 7 parts Angelica dahurica, 7 parts Platycodon grandiflorus, 7 parts Citrus reticulata peel, 7 parts Chrysanthemum indicum, and 7 parts Pogostemon cablin.

[0013] Example 4 A traditional Chinese medicine composition for treating rhinitis The traditional Chinese medicine composition comprises the following components in parts by weight: 7 parts Magnolia biondii, 6 parts Xanthium sibiricum, 6 parts Centipeda minima, 6 parts Ligusticum striatum, 6 parts Ligusticum chuanxiong, 10 parts Houttuynia cordata, 6 parts Angelica dahurica, 6 parts Platycodon grandiflorus, 6 parts Citrus reticulata peel, 6 parts Chrysanthemum indicum, and 6 parts Pogostemon cablin.

[0014] Results Analysis We recruited 100 patients with rhinitis, aged 27-28, including those with acute rhinitis, chronic rhinitis, and allergic rhinitis, excluding those with conditions such as nasal polyps, nasal structural abnormalities, upper respiratory tract infections, or sinus tumors.

[0015] One hundred patients were randomly divided into an experimental group (50 cases) and a control group (50 cases). The experimental group used the traditional Chinese medicine composition of Example 1 of this invention, while the control group received conventional Western medicine treatment (clarithromycin tablets). Both groups were treated continuously for one month.

[0016] Conduct the test as follows: Experimental group: Oral administration of the traditional Chinese medicine composition, three times a day, five pills each time; The control group received oral administration of 0.25g clarithromycin tablets, once daily, one tablet each time; The changes in TCM symptom scores and inflammatory markers of the two groups of patients before and after the test are shown in Tables 1 and 2. Table 1: TCM syndrome scores for the treatment of rhinitis with traditional Chinese medicine compositions Table 2: Inflammatory factor manifestations before and after treatment of rhinitis with traditional Chinese medicine composition: As can be seen from Tables 1 and 2, the traditional Chinese medicine composition disclosed in this invention has a significant effect on the treatment of rhinitis, reducing the expression of inflammatory factors and showing better effects than clarithromycin tablets. It can effectively relieve the symptoms of rhinitis and significantly reduce the TCM syndrome scores of patients with chronic sinusitis, indicating that it has significant efficacy in improving TCM syndromes. The magnolia flower and cocklebur fruit components have anti-inflammatory, anti-allergic, and antibacterial effects, and can also significantly reduce the inflammatory response of the nasal mucosa, reduce local congestion and edema, thereby relieving the symptoms of chronic rhinitis. It can also promote mucosal repair and enhance the barrier function of the nasal mucosa, thereby resisting the invasion of external pathogens.

[0017] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within the invention.

[0018] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A traditional Chinese medicine composition for treating rhinitis, characterized in that: It is made from a combination of Magnolia biondii, Xanthium sibiricum, Centipeda minima, Ligusticum striatum, Ligusticum chuanxiong, Houttuynia cordata, Angelica dahurica, Platycodon grandiflorus, Citrus reticulata peel, Chrysanthemum indicum, and Pogostemon cablin.

2. The traditional Chinese medicine composition for treating rhinitis according to claim 1, characterized in that: The product comprises the following components in parts by weight: Magnolia biondii 5-15 parts, Xanthium sibiricum 3-12 parts, Centipeda minima 3-12 parts, Ligusticum striatum 3-12 parts, Ligusticum chuanxiong 3-12 parts, Houttuynia cordata 10-20 parts, Angelica dahurica 3-12 parts, Platycodon grandiflorus 3-12 parts, Citrus reticulata 3-12 parts, Chrysanthemum indicum 3-12 parts, and Pogostemon cablin 3-12 parts.

3. The traditional Chinese medicine composition for treating rhinitis according to claim 2, characterized in that: The product comprises the following components in parts by weight: Magnolia biondii 8-12 parts, Xanthium sibiricum 8-11 parts, Centipeda minima 5-10 parts, Ligusticum striatum 5-10 parts, Ligusticum chuanxiong 5-10 parts, Houttuynia cordata 10-18 parts, Angelica dahurica 5-10 parts, Platycodon grandiflorus 5-10 parts, Citrus reticulata 5-10 parts, Chrysanthemum indicum 5-10 parts, and Pogostemon cablin 5-10 parts.

4. The traditional Chinese medicine composition for treating rhinitis according to claim 3, characterized in that: The components include the following parts by weight: Magnolia biondii 9-11 parts, Xanthium sibiricum 9-11 parts, Centipeda minima 7-9 parts, Ligusticum striatum 7-9 parts, Ligusticum chuanxiong 7-9 parts, Houttuynia cordata 14-16 parts, Angelica dahurica 7-9 parts, Platycodon grandiflorus 7-9 parts, Citrus reticulata 7-9 parts, Chrysanthemum indicum 7-9 parts, and Pogostemon cablin 7-9 parts.

5. The traditional Chinese medicine composition for treating rhinitis according to claim 4, characterized in that: The ingredients include the following components in parts by weight: 10 parts Magnolia biondii, 10 parts Xanthium sibiricum, 8 parts Centipeda minima, 8 parts Ligusticum striatum, 8 parts Ligusticum chuanxiong, 15 parts Houttuynia cordata, 8 parts Angelica dahurica, 8 parts Platycodon grandiflorus, 8 parts Citrus reticulata peel, 8 parts Chrysanthemum indicum, and 8 parts Pogostemon cablin.

6. A traditional Chinese medicine composition for treating rhinitis according to claims 1-5, characterized in that: The traditional Chinese medicine composition is used to treat acute rhinitis, chronic rhinitis, and allergic rhinitis.

7. The traditional Chinese medicine composition for treating rhinitis according to claim 6, characterized in that: The traditional Chinese medicine composition is mixed with a binder to form pills.

8. The traditional Chinese medicine composition for treating rhinitis according to claim 7, characterized in that: The adhesive is honey or water.

9. A traditional Chinese medicine composition for treating rhinitis according to claim 8, characterized in that: The mass of the pellet is 0.1-0.3g.

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