Highly breathable antibacterial water-oil balance medical dressing and preparation method thereof
By using a method for preparing a composite antibacterial gel and a waterproof and breathable membrane, the problems of insufficient breathability and antibacterial properties of traditional dressings have been solved, resulting in a medical dressing with high breathability, antibacterial properties, and water-oil balance, which promotes wound healing and comfort.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- GUANGZHOU BEIHAO MEDICAL TECH CO LTD
- Filing Date
- 2026-03-11
- Publication Date
- 2026-06-05
AI Technical Summary
Traditional medical dressings have shortcomings in balancing breathability and function. In particular, breathability is limited in high humidity environments, and their antibacterial properties rely on static antibacterial action, which can easily lead to infection risks.
A composite antibacterial gel and waterproof and breathable membrane preparation method is adopted. The non-woven fabric is treated with low temperature plasma, coated with composite antibacterial gel and high pressure bonded with waterproof and breathable membrane to form a highly breathable antibacterial water-oil balanced medical dressing.
It significantly improves the antibacterial properties of the dressing, as well as wound moisture and oil balance, promotes wound healing, prevents fluid accumulation and oil blockage, and enhances comfort and healing efficiency.
Smart Images
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Abstract
Description
Technical Field
[0001] This invention belongs to the field of medical dressing preparation technology, specifically relating to a highly breathable, antibacterial, water-oil balanced medical dressing and its preparation method. Background Technology
[0002] Traditional medical dressings face the challenge of balancing breathability and function in wound care. Early dressings such as dry gauze and oil-based gauze, while able to cover wounds, resulted in sweat accumulation and skin irritation due to their enclosed structure, easily triggering allergies or secondary injury. While hydrocolloid dressings improved breathability through their semi-permeable membrane design, long-term use could still lead to localized moisture due to the enclosed environment, increasing the risk of bacterial growth. Hydrogel dressings, although providing a moist healing environment, have limited breathability due to their dense polymer network structure, especially when there is a lot of exudate, easily creating a hot and humid microenvironment and affecting wound healing efficiency. Furthermore, traditional dressings have limited functionality, making it difficult to simultaneously meet the needs for antibacterial, repair-promoting, and breathable properties. Simply layering functional materials may lead to insufficient carrier breathability, resulting in hindered release of active ingredients or excessively high local concentrations, causing drug resistance. Therefore, developing new dressings that combine high breathability, antibacterial properties, and water-oil balance has become a key direction for overcoming the bottlenecks in the application of traditional dressings.
[0003] Patent CN116173281B discloses a medical dressing and its preparation method. The preparation method of this medical repair dressing includes: heating 4,4'-bis(dimethylhydroxysilyl)diphenyl ether and hexamethylene-1,6-diisocyanate under a catalyst and a first inert atmosphere to obtain isocyanate-terminated polyurethane; under a second inert atmosphere, reacting the isocyanate-terminated polyurethane with 3-aminopropylmorpholine to obtain morpholine-terminated silicone-modified polyurethane; mixing the morpholine-terminated silicone-modified polyurethane with an organic solvent, and then sequentially spinning, drawing, web forming, and hot rolling to obtain the medical repair dressing. Using this as a backing layer for medical dressings can significantly improve the breathability and water resistance of the dressings, thereby effectively improving their performance and extending their service life. Although the aforementioned patent improves the breathability and water resistance of medical dressing backing layers prepared by silicone-modified polyurethane, there is still room for further optimization of its breathability. In particular, in high humidity environments, insufficient porosity and connectivity of the fiber network structure may limit the efficiency of water vapor expulsion. At the same time, the antibacterial properties of this material rely on the static antibacterial effect of morpholine groups and lack an active antibacterial mechanism. Long-term use may lead to infection risks due to microbial colonization. Summary of the Invention
[0004] The purpose of this invention is to provide a highly breathable, antibacterial, water-oil balanced medical dressing and its preparation method, in order to solve the technical problems of poor breathability and antibacterial properties of existing medical dressings.
[0005] To achieve the above objectives, the present invention adopts the following technical solution: This invention provides a method for preparing a highly breathable, antibacterial, water-oil balanced medical dressing, comprising the following steps: Step 1: The nonwoven fabric is subjected to low-temperature plasma treatment to obtain a pretreated substrate. Then, it is laid flat on the conveyor belt of the coating machine, the composite antibacterial gel is poured into the material tank, coated, dried at low temperature, cured, dried, cooled, and cut to obtain the composite antibacterial gel layer. Step 2: Align the waterproof and breathable membrane with the composite antibacterial gel layer, and perform high-pressure lamination to obtain a composite layer. On the side of the composite layer without the composite antibacterial gel layer, apply medical pressure-sensitive adhesive, cover with release paper, stamp and shape, trim the edges, sterilize, and package to obtain a highly breathable, antibacterial, water-oil balanced medical dressing.
[0006] Preferably, the preparation method of the composite antibacterial gel includes the following steps: Q1: In a water bath environment, 3,5-bis(trifluoromethyl)aniline and hydrochloric acid were added to a container, followed by sodium dicyandiamide aqueous solution. After stirring and mixing, the mixture was filtered, washed, and dried under vacuum to obtain compound 1. Q2: Compound 1 was added to a container containing an aqueous solution of tetrahydrofuran, then copper sulfate pentahydrate and octadecylamine were added. After heating and stirring, the mixture was distilled under reduced pressure, cooled, hydrochloric acid was added and stirred, EDTA was added dropwise and stirred, filtered, washed, and dried to obtain compound 2. Q3: Add chitosan to a container containing hydrochloric acid, stir and react, then add compound 2, heat and reflux, stir, cool, add acetone to precipitate, centrifuge, wash, and dry to obtain a composite antibacterial gel.
[0007] The synthesis reaction formula for organic compound 2 in the above process is as follows:
[0008] The mass spectrometry analysis results of compound 1 were: m / z: 296.05 (100.0%), 297.05 (12.3%); the mass spectrometry analysis results of compound 2 were: m / z: 565.36 (100.0%), 566.36 (30.8%), 567.36 (5.0%), 566.35 (1.8%).
[0009] Preferably, in Q1, the water bath temperature is 80-83℃, the ratio of 3,5-bis(trifluoromethyl)aniline, hydrochloric acid, and sodium dicyandiamide aqueous solution is (1.92-2.37) g : (1.83-2.06) mL : (0.62-1.17) mL, the concentration of hydrochloric acid is 1 mol / L, the concentration of sodium dicyandiamide aqueous solution is 1 g / mL, the mixing reaction time is 4-6 h, and the mixture is washed with distilled water.
[0010] Preferably, in Q2, the ratio of compound 1, tetrahydrofuran aqueous solution, copper sulfate pentahydrate, and octadecylamine is (1.78-1.94) g : (12-16) mL : (0.49-0.63) g : (0.23-0.44) g, the volume fraction of tetrahydrofuran aqueous solution is 10 vt%, the heating and stirring reaction temperature is 38-42℃, the time is 4-6 h, 1 mol / L hydrochloric acid is added and stirred for 30-45 min, and EDTA is added dropwise and stirred for 25-45 min.
[0011] Preferably, in Q3, the ratio of chitosan, hydrochloric acid and compound 2 is (2-2.7) g: (90-110) mL: (2.89-3.35) g, the volume fraction of hydrochloric acid is 1 wt%, the stirring reaction time is 30-45 min, the heating and reflux stirring temperature is 90-92℃, the time is 2-4 h, centrifugation is performed at 4000-4500 rpm for 10-12 min, and washing is performed with acetone.
[0012] Preferably, the method for preparing the waterproof and breathable membrane includes the following steps: S1: 2-Acrylamido-2-methylpropanesulfonic acid, butyl acrylate and mercaptoglycerol were added to a container containing N,N-dimethylformamide, stirred and mixed, and then azobisisobutyronitrile was added. The mixture was heated under a nitrogen atmosphere and then transferred to tetrahydrofuran to precipitate. After filtration, product a was obtained. S2: Isophorone diisocyanate, polyethylene glycol and dibutyltin dilaurate are added to a container and heated to react. Then product a is added and the reaction is continued. Hydroxyethyl methacrylate is added and stirred to react. The mixture is then added to a container containing N,N-dimethylformamide, followed by N,N-dimethylpropionamide. After stirring and mixing, the mixture is poured into a mold, exposed to light, and vacuum dried to obtain a waterproof and breathable membrane.
[0013] In the above process, 2-acrylamido-2-methylpropanesulfonic acid, butyl acrylate, and mercaptoglycerol undergo free radical copolymerization and chain transfer under the condition of azobisisobutyronitrile as an initiator to obtain product a. Subsequently, isophorone diisocyanate and polyethylene glycol react to generate a polyurethane prepolymer with isocyanate groups at both ends. Then, the terminal hydroxyl groups of product a react with the polyurethane prepolymer. Finally, hydroxyethyl methacrylate is introduced, and curing occurs under ultraviolet light to obtain a waterproof and breathable membrane.
[0014] Preferably, in S1, the ratio of 2-acrylamido-2-methylpropanesulfonic acid, butyl acrylate, mercaptoglycerol, N,N-dimethylformamide, azobisisobutyronitrile, and tetrahydrofuran is (1.02-1.43) g : (0.48-0.54) g : (0.08-0.12) g : (5.32-5.65) g : (0.0031-0.0035) g : (18.88-22.32) g, and the mixture is heated to 80-82°C and reacted for 20-24 h.
[0015] Preferably, in step S2, the ratio of isophorone diisocyanate, polyethylene glycol, dibutyltin dilaurate, product a, hydroxyethyl methacrylate, N,N-dimethylformamide, and N,N-dimethylpropionamide is (0.92-1.32) g : (1.88-2.32) g : (0.004-0.006) g : (0.82-1.04) g : (1.02-1.35) g : (8.83-9.27) g : (1.35-1.59) g. The reaction is heated to 70-74℃ for 2-3 hours, and then heated for another 4-6 hours. The reaction is stirred for 2-3 hours. During the illumination process, the wavelength of the ultraviolet lamp is 365 nm, the light intensity is 80%, and the illumination time is 300-320 s.
[0016] Preferably, in step one, the low-temperature plasma treatment power is 10-40W, the time is 200-300s, the vacuum degree is 15-80Pa, the treatment gas is argon, the coating speed is 10-50m / min, the drying temperature is 60-80℃, and the time is 2-4min; in step two, the high-pressure composite pressure is 0.1-0.8MPa, the temperature is 40-50℃, and the coating pressure is 0.2-0.6MPa during the coating of medical pressure-sensitive adhesive.
[0017] As a preferred option, the highly breathable, antibacterial, water-oil balanced medical dressing is prepared using the preparation method described above.
[0018] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are: 1. In the process of preparing medical dressings, this invention uses composite antibacterial gel and waterproof and breathable membrane, which can not only effectively improve the antibacterial properties of the dressing, but also effectively regulate the humidity and oil balance of the wound microenvironment, thereby promoting wound healing.
[0019] 2. The composite antibacterial gel obtained in this invention can be applied to medical dressings, which can effectively improve their antibacterial performance. The chitosan matrix in the composite antibacterial gel has good biocompatibility and hygroscopicity, which can quickly absorb excess wound exudate. At the same time, it locks in moisture through a three-dimensional network structure, maintains a moist environment, and is conducive to tissue repair. The loaded compound 2 provides a synergistic antibacterial effect. The guanidine group can destroy the cell membrane of microorganisms, achieving broad-spectrum inhibition of bacteria and fungi. In addition, the hydrophobic component introduced by octadecylamine can work synergistically with the hydrophilic properties of chitosan to intelligently regulate the water-oil balance on the dressing surface, preventing excessive oil accumulation that could lead to blockage and avoiding excessive dryness, thereby optimizing the comfort and breathability of the wound contact surface.
[0020] 3. This invention applies the prepared waterproof and breathable membrane to medical dressings, effectively regulating the humidity and oil balance of the wound microenvironment, significantly promoting wound healing. The sulfonic acid groups and polyethylene glycol segments in the waterproof and breathable membrane form a strongly hydrophilic region, which can efficiently adsorb and guide the diffusion of water vapor in wound exudate, achieving rapid moisture permeability and preventing fluid accumulation. At the same time, the hydrophobic segments of butyl acrylate and the cross-linked network form a dense barrier, effectively blocking the intrusion of external liquid water, bacteria, and contaminants. In addition, the membrane can selectively permeate water molecules while blocking oil and pathogens, thereby maintaining appropriate wound moisture and reducing oil blockage, achieving dual optimization of moist healing and oil-water balance, improving the comfort, protection, and healing efficiency of the dressing. Detailed Implementation
[0021] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0022] Example 1: This example discloses a method for preparing a composite antibacterial gel, including the following steps: Q1: In an 80℃ water bath environment, 2.18g of 3,5-bis(trifluoromethyl)aniline and 1.94mL of 1mol / L hydrochloric acid were added to a container, followed by 0.84mL of 1g / mL sodium dicyandiamide aqueous solution. After stirring and mixing for 4h, the mixture was filtered, washed with distilled water, and dried under vacuum to obtain compound 1. Q2: 1.82 g of compound 1 was added to a container containing 14 mL of 10 vt% tetrahydrofuran aqueous solution, followed by 0.56 g of copper sulfate pentahydrate and 0.33 g of octadecylamine. The mixture was heated and stirred at 40 °C for 6 h, then distilled under reduced pressure, cooled, and 1 mol / L hydrochloric acid was added and stirred for 30 min. EDTA was added dropwise and stirred for 45 min. The mixture was then filtered, washed, and dried to obtain compound 2. Q3: Add 2.35g of chitosan to a container containing 100mL of 1vt% hydrochloric acid. After stirring for 30min, add 3.11g of compound 2. Heat at 90℃ and reflux for 4h. After cooling, add acetone to precipitate the precipitate. Centrifuge at 4500rpm for 10min, wash with acetone, and dry to obtain the composite antibacterial gel.
[0023] This embodiment discloses a method for preparing a waterproof and breathable membrane, including the following steps: S1: 1.22g of 2-acrylamido-2-methylpropanesulfonic acid, 0.51g of butyl acrylate and 0.1g of mercaptoglycerol were added to a container containing 5.43g of N,N-dimethylformamide. After stirring and mixing, 0.0033g of azobisisobutyronitrile was added. The mixture was heated to 80℃ and reacted for 24h under a nitrogen atmosphere. The mixture was then transferred to 20.51g of tetrahydrofuran, and a precipitate was formed. The precipitate was filtered to obtain product a. S2: 1.12g of isophorone diisocyanate, 2.15g of polyethylene glycol with a relative molecular mass of 1000 and 0.005g of dibutyltin dilaurate were added to a container and heated to 70℃ for 2 hours. Then, 0.93g of product a was added and the reaction was continued at 70℃ for 6 hours. Then, 1.18g of hydroxyethyl methacrylate was added and stirred at 70℃ for 2 hours. The mixture was then added to a container containing 9.05g of N,N-dimethylformamide, followed by 1.47g of N,N-dimethylpropionamide. After stirring and mixing, the mixture was poured into a mold and irradiated with UV light. During the irradiation process, the UV lamp wavelength was 365nm, the light intensity was 80%, and the irradiation time was 320s. The mixture was then vacuum dried to obtain a waterproof and breathable membrane.
[0024] This embodiment discloses a method for preparing a highly breathable, antibacterial, water-oil balanced medical dressing, including the following steps: Step 1: The nonwoven fabric is subjected to low-temperature plasma treatment with a power of 30W, a time of 280s, a vacuum degree of 40Pa, and argon gas to obtain a pretreated substrate. The substrate is then laid flat on the conveyor belt of the coating machine. The composite antibacterial gel is poured into the material tank and coated at a speed of 30m / min. The substrate is dried at 35℃ for 1min, cured, dried at 80℃ for 2min, cooled, and cut to obtain the composite antibacterial gel layer. Step 2: Align the waterproof and breathable membrane with the composite antibacterial gel layer, perform high-pressure lamination at 0.5 MPa and 45°C to obtain the composite layer. On the side of the composite layer without the composite antibacterial gel layer, apply medical pressure-sensitive adhesive at 0.4 MPa, cover with release paper, stamp and shape, trim the edges, sterilize, and package to obtain a highly breathable, antibacterial, water-oil balanced medical dressing.
[0025] Example 2: This example discloses a method for preparing a composite antibacterial gel, including the following steps: Q1: In an 80℃ water bath environment, 2.37g of 3,5-bis(trifluoromethyl)aniline and 1.83mL of 1mol / L hydrochloric acid were added to a container, followed by 0.62mL of 1g / mL sodium dicyandiamide aqueous solution. After stirring and mixing for 4h, the mixture was filtered, washed with distilled water, and dried under vacuum to obtain compound 1. Q2: 1.94 g of compound 1 was added to a container containing 16 mL of 10 vt% tetrahydrofuran aqueous solution, followed by 0.49 g of copper sulfate pentahydrate and 0.23 g of octadecylamine. The mixture was heated and stirred at 40 °C for 6 h, then distilled under reduced pressure, cooled, and 1 mol / L hydrochloric acid was added and stirred for 30 min. EDTA was added dropwise and stirred for 45 min. The mixture was then filtered, washed, and dried to obtain compound 2. Q3: Add 2.7g of chitosan to a container containing 110mL of 1vt% hydrochloric acid. After stirring for 30min, add 2.89g of compound 2. Heat at 90℃ and reflux for 4h. After cooling, add acetone to precipitate the precipitate. Centrifuge at 4500rpm for 10min, wash with acetone, and dry to obtain the composite antibacterial gel.
[0026] This embodiment discloses a method for preparing a waterproof and breathable membrane, including the following steps: S1: 1.02 g of 2-acrylamido-2-methylpropanesulfonic acid, 0.48 g of butyl acrylate and 0.12 g of mercaptoglycerol were added to a container containing 5.32 g of N,N-dimethylformamide. After stirring and mixing, 0.0031 g of azobisisobutyronitrile was added. The mixture was heated to 80 °C and reacted for 24 h under a nitrogen atmosphere. The mixture was then transferred to 18.88 g of tetrahydrofuran, and a precipitate was formed. The precipitate was filtered to obtain product a. S2: 0.92g of isophorone diisocyanate, 1.88g of polyethylene glycol with a relative molecular mass of 1000 and 0.006g of dibutyltin dilaurate were added to a container and heated to 70℃ for 2 hours. Then, 0.82g of product a was added, and the reaction was continued at 70℃ for 6 hours. Then, 1.35g of hydroxyethyl methacrylate was added, and the mixture was stirred at 70℃ for 2 hours. The mixture was then added to a container containing 8.83g of N,N-dimethylformamide, followed by 1.35g of N,N-dimethylpropionamide. After stirring and mixing, the mixture was poured into a mold and irradiated with UV light. During the irradiation process, the UV lamp wavelength was 365nm, the light intensity was 80%, and the irradiation time was 320s. The mixture was then vacuum dried to obtain a waterproof and breathable membrane.
[0027] This embodiment discloses a method for preparing a highly breathable, antibacterial, water-oil balanced medical dressing, including the following steps: Step 1: The nonwoven fabric is subjected to low-temperature plasma treatment with a power of 30W, a time of 280s, a vacuum degree of 40Pa, and argon gas to obtain a pretreated substrate. The substrate is then laid flat on the conveyor belt of the coating machine. The composite antibacterial gel is poured into the material tank and coated at a speed of 30m / min. The substrate is dried at 35℃ for 1min, cured, dried at 80℃ for 2min, cooled, and cut to obtain the composite antibacterial gel layer. Step 2: Align the waterproof and breathable membrane with the composite antibacterial gel layer, perform high-pressure lamination at 0.5 MPa and 45°C to obtain the composite layer. On the side of the composite layer without the composite antibacterial gel layer, apply medical pressure-sensitive adhesive at 0.4 MPa, cover with release paper, stamp and shape, trim the edges, sterilize, and package to obtain a highly breathable, antibacterial, water-oil balanced medical dressing.
[0028] Example 3: This example discloses a method for preparing a composite antibacterial gel, including the following steps: Q1: In an 80℃ water bath environment, 1.92g of 3,5-bis(trifluoromethyl)aniline and 2.06mL of 1mol / L hydrochloric acid were added to a container, followed by 1.17mL of 1g / mL sodium dicyandiamide aqueous solution. After stirring and mixing for 4h, the mixture was filtered, washed with distilled water, and dried under vacuum to obtain compound 1. Q2: 1.78 g of compound 1 was added to a container containing 12 mL of 10 vt% tetrahydrofuran aqueous solution, followed by 0.63 g of copper sulfate pentahydrate and 0.44 g of octadecylamine. The mixture was heated and stirred at 40 °C for 6 h, then distilled under reduced pressure, cooled, and 1 mol / L hydrochloric acid was added and stirred for 30 min. EDTA was added dropwise and stirred for 45 min. The mixture was then filtered, washed, and dried to obtain compound 2. Q3: Add 2g of chitosan to a container containing 90mL of 1vt% hydrochloric acid. After stirring for 30min, add 3.35g of compound 2. Heat at 90℃ and reflux for 4h. After cooling, add acetone to precipitate the precipitate. Centrifuge at 4500rpm for 10min, wash with acetone, and dry to obtain the composite antibacterial gel.
[0029] This embodiment discloses a method for preparing a waterproof and breathable membrane, including the following steps: S1: 1.43g of 2-acrylamido-2-methylpropanesulfonic acid, 0.54g of butyl acrylate and 0.08g of mercaptoglycerol were added to a container containing 5.65g of N,N-dimethylformamide. After stirring and mixing, 0.0035g of azobisisobutyronitrile was added. The mixture was heated to 80℃ and reacted for 24h under a nitrogen atmosphere. The mixture was then transferred to 22.32g of tetrahydrofuran, and a precipitate was formed. The precipitate was filtered to obtain product a. S2: 1.32g of isophorone diisocyanate, 2.32g of polyethylene glycol with a relative molecular mass of 1000 and 0.004g of dibutyltin dilaurate were added to a container and heated to 70℃ for 2 hours. Then, 1.04g of product a was added and the reaction was continued at 70℃ for 6 hours. Then, 1.02g of hydroxyethyl methacrylate was added and stirred at 70℃ for 2 hours. The mixture was then added to a container containing 9.27g of N,N-dimethylformamide, followed by 1.59g of N,N-dimethylpropionamide. After stirring and mixing, the mixture was poured into a mold and irradiated with UV light. During the irradiation process, the UV lamp wavelength was 365nm, the light intensity was 80%, and the irradiation time was 320s. The mixture was then vacuum dried to obtain a waterproof and breathable membrane.
[0030] This embodiment discloses a method for preparing a highly breathable, antibacterial, water-oil balanced medical dressing, including the following steps: Step 1: The nonwoven fabric is subjected to low-temperature plasma treatment with a power of 30W, a time of 280s, a vacuum degree of 40Pa, and argon gas to obtain a pretreated substrate. The substrate is then laid flat on the conveyor belt of the coating machine. The composite antibacterial gel is poured into the material tank and coated at a speed of 30m / min. The substrate is dried at 35℃ for 1min, cured, dried at 80℃ for 2min, cooled, and cut to obtain the composite antibacterial gel layer. Step 2: Align the waterproof and breathable membrane with the composite antibacterial gel layer, perform high-pressure lamination at 0.5 MPa and 45°C to obtain the composite layer. On the side of the composite layer without the composite antibacterial gel layer, apply medical pressure-sensitive adhesive at 0.4 MPa, cover with release paper, stamp and shape, trim the edges, sterilize, and package to obtain a highly breathable, antibacterial, water-oil balanced medical dressing.
[0031] Example 4: This example discloses a method for preparing a composite antibacterial gel, including the following steps: Q1: In an 80℃ water bath environment, 2.07g of 3,5-bis(trifluoromethyl)aniline and 1.88mL of 1mol / L hydrochloric acid were added to a container, followed by 0.74mL of 1g / mL sodium dicyandiamide aqueous solution. After stirring and mixing for 4h, the mixture was filtered, washed with distilled water, and dried under vacuum to obtain compound 1. Q2: 1.8 g of compound 1 was added to a container containing 13 mL of 10 vt% tetrahydrofuran aqueous solution, followed by 0.53 g of copper sulfate pentahydrate and 0.28 g of octadecylamine. The mixture was heated and stirred at 40 °C for 6 h, then distilled under reduced pressure, cooled, and 1 mol / L hydrochloric acid was added and stirred for 30 min. EDTA was added dropwise and stirred for 45 min. The mixture was then filtered, washed, and dried to obtain compound 2. Q3: Add 2.1g of chitosan to a container containing 95mL of 1vt% hydrochloric acid. After stirring for 30min, add 3.08g of compound 2. Heat at 90℃ and reflux for 4h. After cooling, add acetone to precipitate the precipitate. Centrifuge at 4500rpm for 10min, wash with acetone, and dry to obtain the composite antibacterial gel.
[0032] This embodiment discloses a method for preparing a waterproof and breathable membrane, including the following steps: S1: 1.17g of 2-acrylamido-2-methylpropanesulfonic acid, 0.49g of butyl acrylate and 0.09g of mercaptoglycerol were added to a container containing 5.38g of N,N-dimethylformamide. After stirring and mixing, 0.0032g of azobisisobutyronitrile was added. The mixture was heated to 80℃ and reacted for 24h under a nitrogen atmosphere. The mixture was then transferred to 19.17g of tetrahydrofuran, and a precipitate was formed. The precipitate was filtered to obtain product a. S2: 1.06g of isophorone diisocyanate, 1.96g of polyethylene glycol with a relative molecular mass of 1000 and 0.006g of dibutyltin dilaurate were added to a container and heated to 70℃ for 2 hours. Then, 0.86g of product a was added and the reaction was continued at 70℃ for 6 hours. Then, 1.27g of hydroxyethyl methacrylate was added and stirred at 70℃ for 2 hours. The mixture was then added to a container containing 8.91g of N,N-dimethylformamide, followed by 1.41g of N,N-dimethylpropionamide. After stirring and mixing, the mixture was poured into a mold and irradiated with UV light. During the irradiation process, the UV lamp wavelength was 365nm, the light intensity was 80%, and the irradiation time was 320s. The mixture was then vacuum dried to obtain a waterproof and breathable membrane.
[0033] This embodiment discloses a method for preparing a highly breathable, antibacterial, water-oil balanced medical dressing, including the following steps: Step 1: The nonwoven fabric is subjected to low-temperature plasma treatment with a power of 30W, a time of 280s, a vacuum degree of 40Pa, and argon gas to obtain a pretreated substrate. The substrate is then laid flat on the conveyor belt of the coating machine. The composite antibacterial gel is poured into the material tank and coated at a speed of 30m / min. The substrate is dried at 35℃ for 1min, cured, dried at 80℃ for 2min, cooled, and cut to obtain the composite antibacterial gel layer. Step 2: Align the waterproof and breathable membrane with the composite antibacterial gel layer, perform high-pressure lamination at 0.5 MPa and 45°C to obtain the composite layer. On the side of the composite layer without the composite antibacterial gel layer, apply medical pressure-sensitive adhesive at 0.4 MPa, cover with release paper, stamp and shape, trim the edges, sterilize, and package to obtain a highly breathable, antibacterial, water-oil balanced medical dressing.
[0034] Example 5: This example discloses a method for preparing a composite antibacterial gel, including the following steps: Q1: In an 80℃ water bath environment, 2.22g of 3,5-bis(trifluoromethyl)aniline and 2.01mL of 1mol / L hydrochloric acid were added to a container, followed by 1.03mL of 1g / mL sodium dicyandiamide aqueous solution. After stirring and mixing for 4h, the mixture was filtered, washed with distilled water, and dried under vacuum to obtain compound 1. Q2: 1.92 g of compound 1 was added to a container containing 15 mL of 10 vt% tetrahydrofuran aqueous solution, followed by 0.61 g of copper sulfate pentahydrate and 0.41 g of octadecylamine. The mixture was heated and stirred at 40 °C for 6 h, then distilled under reduced pressure, cooled, and 1 mol / L hydrochloric acid was added and stirred for 30 min. EDTA was added dropwise and stirred for 45 min. The mixture was then filtered, washed, and dried to obtain compound 2. Q3: Add 2.6g of chitosan to a container containing 105mL of 1vt% hydrochloric acid. After stirring for 30min, add 3.21g of compound 2. Heat at 90℃ and reflux for 4h. After cooling, add acetone to precipitate the precipitate. Centrifuge at 4500rpm for 10min, wash with acetone, and dry to obtain the composite antibacterial gel.
[0035] This embodiment discloses a method for preparing a waterproof and breathable membrane, including the following steps: S1: 1.36 g of 2-acrylamido-2-methylpropanesulfonic acid, 0.53 g of butyl acrylate and 0.11 g of mercaptoglycerol were added to a container containing 5.51 g of N,N-dimethylformamide. After stirring and mixing, 0.0034 g of azobisisobutyronitrile was added. The mixture was heated to 80 °C and reacted for 24 h under a nitrogen atmosphere. The mixture was then transferred to 21.12 g of tetrahydrofuran, and a precipitate was formed. The precipitate was filtered to obtain product a. S2: 1.27g of isophorone diisocyanate, 2.23g of polyethylene glycol with a relative molecular mass of 1000 and 0.004g of dibutyltin dilaurate were added to a container and heated to 70℃ for 2 hours. Then, 0.98g of product a was added and the reaction was continued at 70℃ for 6 hours. Then, 1.11g of hydroxyethyl methacrylate was added and stirred at 70℃ for 2 hours. The mixture was then added to a container containing 9.18g of N,N-dimethylformamide, followed by 1.52g of N,N-dimethylpropionamide. After stirring and mixing, the mixture was poured into a mold and irradiated with UV light. During the irradiation process, the UV lamp wavelength was 365nm, the light intensity was 80%, and the irradiation time was 320s. The mixture was then vacuum dried to obtain a waterproof and breathable membrane.
[0036] This embodiment discloses a method for preparing a highly breathable, antibacterial, water-oil balanced medical dressing, including the following steps: Step 1: The nonwoven fabric is subjected to low-temperature plasma treatment with a power of 30W, a time of 280s, a vacuum degree of 40Pa, and argon gas to obtain a pretreated substrate. The substrate is then laid flat on the conveyor belt of the coating machine. The composite antibacterial gel is poured into the material tank and coated at a speed of 30m / min. The substrate is dried at 35℃ for 1min, cured, dried at 80℃ for 2min, cooled, and cut to obtain the composite antibacterial gel layer. Step 2: Align the waterproof and breathable membrane with the composite antibacterial gel layer, perform high-pressure lamination at 0.5 MPa and 45°C to obtain the composite layer. On the side of the composite layer without the composite antibacterial gel layer, apply medical pressure-sensitive adhesive at 0.4 MPa, cover with release paper, stamp and shape, trim the edges, sterilize, and package to obtain a highly breathable, antibacterial, water-oil balanced medical dressing.
[0037] Comparative Example 1: Compared with Example 1, Comparative Example 1 did not use composite antibacterial gel in the preparation of medical dressings, while all other conditions remained unchanged.
[0038] Comparative Example 2: Compared with Example 1, Comparative Example 2 uses a polyethylene film instead of a waterproof and breathable film in the preparation of the medical dressing, while keeping all other conditions unchanged.
[0039] Performance testing: The medical dressings prepared in Examples 1-5 and Comparative Examples 1-2 were subjected to performance tests. In vitro cytotoxicity was tested according to GB / T 16886.5-2017; skin sensitization was tested according to GB / T 16886.10-2024; water vapor permeability was tested according to GB / T 1037-2021; and antibacterial activity was tested according to GB / T 20944.1-2007. The test results are shown in Table 1.
[0040] The cytotoxicity morphology grading of extracts is typically divided into four levels: Grade 0 (no cytotoxicity), Grade 1 (mild), Grade 2 (mild), Grade 3 (moderate), and Grade 4 (severe). Samples prepared according to the methods of Examples 1-5 and Comparative Examples 1-2 all exhibited good biocompatibility, with a cytotoxicity rating of Grade 0 for all. The patch test reaction grades were divided into four levels: Grade 0 (no significant change), Grade 1 (sporadic or patchy erythema), Grade 2 (moderate confluent erythema), and Grade 3 (severe erythema and / or edema). The prepared samples showed extremely low skin sensitization, with no reaction observed in the patch test. A higher water vapor permeability value indicates better moisture permeability. A comparison between Comparative Example 2 and Examples 1-5 shows that the use of a waterproof and breathable membrane can effectively improve the moisture permeability of the samples. A wider antibacterial band indicates stronger antibacterial performance. A comparison between Comparative Example 1 and Examples 1-5 shows that the use of a composite antibacterial gel can effectively improve the antibacterial performance of the samples.
[0041] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.
[0042] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to specific implementations. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.
Claims
1. A method for preparing a highly breathable, antibacterial, water-oil balanced medical dressing, characterized in that, Includes the following steps: Step 1: The nonwoven fabric is subjected to low-temperature plasma treatment to obtain a pretreated substrate. Then, it is laid flat on the conveyor belt of the coating machine, the composite antibacterial gel is poured into the material tank, coated, dried at low temperature, cured, dried, cooled, and cut to obtain the composite antibacterial gel layer. Step 2: Align the waterproof and breathable membrane with the composite antibacterial gel layer, and perform high-pressure lamination to obtain a composite layer. On the side of the composite layer without the composite antibacterial gel layer, apply medical pressure-sensitive adhesive, cover with release paper, stamp and shape, trim the edges, sterilize, and package to obtain a highly breathable, antibacterial, water-oil balanced medical dressing.
2. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 1, characterized in that, The preparation method of the composite antibacterial gel, Includes the following steps: Q1: In a water bath environment, 3,5-bis(trifluoromethyl)aniline and hydrochloric acid were added to a container, followed by sodium dicyandiamide aqueous solution. After stirring and mixing, the mixture was filtered, washed, and dried under vacuum to obtain compound 1. Q2: Compound 1 was added to a container containing an aqueous solution of tetrahydrofuran, then copper sulfate pentahydrate and octadecylamine were added. After heating and stirring, the mixture was distilled under reduced pressure, cooled, hydrochloric acid was added and stirred, EDTA was added dropwise and stirred, filtered, washed, and dried to obtain compound 2. Q3: Add chitosan to a container containing hydrochloric acid, stir and react, then add compound 2, heat and reflux, stir, cool, add acetone to precipitate, centrifuge, wash, and dry to obtain a composite antibacterial gel.
3. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 2, characterized in that, In Q1, the ratio of the amounts of 3,5-bis(trifluoromethyl)aniline, hydrochloric acid, and sodium dicyandiamide aqueous solution is (1.92-2.37) g : (1.83-2.06) mL : (0.62-1.17) mL.
4. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 2, characterized in that, In Q2, the ratio of compound 1, tetrahydrofuran aqueous solution, copper sulfate pentahydrate and octadecylamine is (1.78-1.94) g : (12-16) mL : (0.49-0.63) g : (0.23-0.44) g.
5. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 2, characterized in that, In Q3, the ratio of chitosan, hydrochloric acid and compound 2 is (2-2.7) g: (90-110) mL: (2.89-3.35) g.
6. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 1, characterized in that, The method for preparing the waterproof and breathable membrane includes the following steps: S1: 2-Acrylamido-2-methylpropanesulfonic acid, butyl acrylate and mercaptoglycerol were added to a container containing N,N-dimethylformamide, stirred and mixed, and then azobisisobutyronitrile was added. The mixture was heated under a nitrogen atmosphere and then transferred to tetrahydrofuran to precipitate. After filtration, product a was obtained. S2: Isophorone diisocyanate, polyethylene glycol and dibutyltin dilaurate are added to a container and heated to react. Then product a is added and the reaction is continued. Hydroxyethyl methacrylate is added and stirred to react. The mixture is then added to a container containing N,N-dimethylformamide, followed by N,N-dimethylpropionamide. After stirring and mixing, the mixture is poured into a mold, exposed to light, and vacuum dried to obtain a waterproof and breathable membrane.
7. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 6, characterized in that, In S1, the ratio of 2-acrylamido-2-methylpropanesulfonic acid, butyl acrylate, mercaptoglycerol, N,N-dimethylformamide, azobisisobutyronitrile, and tetrahydrofuran is (1.02-1.43) g : (0.48-0.54) g : (0.08-0.12) g : (5.32-5.65) g : (0.0031-0.0035) g : (18.88-22.32) g.
8. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 6, characterized in that, In S2, the ratio of isophorone diisocyanate, polyethylene glycol, dibutyltin dilaurate, product a, hydroxyethyl methacrylate, N,N-dimethylformamide, and N,N-dimethylpropionamide is (0.92-1.32) g : (1.88-2.32) g : (0.004-0.006) g : (0.82-1.04) g : (1.02-1.35) g : (8.83-9.27) g : (1.35-1.59) g.
9. The preparation method of the highly breathable, antibacterial, water-oil balanced medical dressing according to claim 1, characterized in that, In step one, the low-temperature plasma treatment power is 10-40W, the time is 200-300s, the vacuum degree is 15-80Pa, the treatment gas is argon, the coating speed is 10-50m / min, the drying temperature is 60-80℃, and the time is 2-4min. In step two, the high-pressure composite pressure is 0.1-0.8MPa, the temperature is 40-50℃, and the coating pressure is 0.2-0.6MPa during the coating of medical pressure-sensitive adhesive.
10. A highly breathable, antibacterial, water-oil balanced medical dressing, characterized in that... It is prepared by the preparation method described in any one of claims 1-9.