A multi-cooperative regulation composite bone bonding system and a preparation method and application thereof

By using a multi-synergistic control composite bone bonding system, the reaction temperature and curing time of calcium phosphate cement are controlled to generate hydroxyapatite, which solves the problems of excessively fast curing speed and insufficient strength of calcium phosphate cement, and achieves a safe and controllable bone bonding effect.

CN122140984APending Publication Date: 2026-06-05HANGZHOU ORIGO BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HANGZHOU ORIGO BIOTECHNOLOGY CO LTD
Filing Date
2026-04-16
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing calcium phosphate cement (CPC) bone binders have excessively fast curing speeds, insufficient strength, and high reaction temperatures, leading to tissue damage and side effects, and are difficult to meet complex clinical needs.

Method used

A multi-synergistically regulated composite bone bonding system is adopted, which involves the reaction of phosphoserine, tetracalcium phosphate and polybasic calcium phosphate in a liquid environment with adjustable acidity and alkalinity to form an interfacial barrier and gradient dissolution-precipitation kinetic sequence. The reaction temperature is controlled, and acidic calcium phosphate is introduced to generate hydroxyapatite to improve bioactivity.

Benefits of technology

It achieves a mild and controllable curing process, improves the mechanical strength and bioactivity of bone adhesives, avoids high-temperature tissue damage, meets clinical operation requirements, and is suitable for fracture repair and bone defect filling.

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Abstract

The application discloses a kind of multi-coordinated control composite bone bonding system and its preparation method and application.The composite bone bonding system includes powder component and liquid buffer component.The powder component contains phosphoserine, tetracalcium phosphate and other basic calcium phosphate salt;The mass content of phosphoserine in the powder component is 10%~50%, and the mass content of tetracalcium phosphate in the powder component is 10%~50%.The liquid buffer component is the mixed solution of citric acid and disodium hydrogen phosphate, and the pH value range is 4.4~9.4.By mixing powder component and liquid buffer component, the paste-like composite bone bonding system can be made.The application realizes the reaction control of acid-base neutralization by the material selection of powder component and the pH adjustment of liquid buffer component, reduces the solidification temperature rise, and inhibits local overheating, and the composite bone bonding system can be applied as bone repair biomaterial, dental repair biomaterial or oral implant.
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