Piperidinedione compounds, methods of making the same, pharmaceutical compositions thereof, and uses thereof
By designing piperidine dione compounds with specific structures, the problem of the single structure of existing VAV1 molecular glue degraders has been solved, and effective targeted degradation of VAV1 has been achieved, which has the potential to treat autoimmune diseases.
CN122145434APending Publication Date: 2026-06-05CHANGCHUN GENESCIENCE PHARM CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- CHANGCHUN GENESCIENCE PHARM CO LTD
- Filing Date
- 2025-12-02
- Publication Date
- 2026-06-05
AI Technical Summary
Technical Problem
Existing VAV1 molecular adhesive degraders have a simple structure and lack effective degradation effects.
Method used
A piperidine dione compound is provided that targets the degradation of VAV1 through a compound designed with a specific structure, including a combination of a C6-10 aromatic ring or a 5-6 membered heteroaromatic ring ring A, a linker L1 and a substituent R1, to meet specific conditions to improve the degradation effect.
Benefits of technology
It achieves effective degradation of VAV1, has good potential for pharmaceutical composition applications, and may be used to treat a variety of autoimmune diseases.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN122145434A_ABST
Abstract
The application discloses a piperidinedione compound, a preparation method of the piperidinedione compound, and a pharmaceutical composition and application of the piperidinedione compound. The application provides a compound shown in formula (I) or a pharmaceutically acceptable salt of the compound. The compound of the application has a good degradation effect on VAV1.
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Citation Information
Patent Citations
Targeted degradation of VAV1
WO2024151547A1