Influenza virus D isolate D / HY11 and use thereof in a ferret model of infection

By studying the airborne transmission of influenza D virus isolate D/HY11 in a ferret model, the problem of insufficient airborne transmission assessment in existing models was solved, an effective airborne transmission system was established, the transmission pattern of IDV was revealed, and important evidence was provided for prevention and control strategies and vaccine development.

CN122146622APending Publication Date: 2026-06-05ACAD OF MILITARY SCI PLA CHINA ACAD OF MILITARY MEDICAL SCI INST OF MILITARY VETERINARY MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ACAD OF MILITARY SCI PLA CHINA ACAD OF MILITARY MEDICAL SCI INST OF MILITARY VETERINARY MEDICINE
Filing Date
2025-12-22
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing animal models of IDV are insufficient in studying its pathogenic mechanisms, transmission characteristics, and immune responses. There is a lack of ideal small animal models, especially in assessing its airborne transmission capacity, which affects IDV control strategies and vaccine development.

Method used

The transmission of influenza D virus isolate D/HY11 was studied in a ferret model. The transmission dynamics among ferrets were evaluated by whole-genome sequencing and amino acid mutation analysis. Host adaptability was analyzed by computer simulation of protein conformation and receptor molecular docking, and an effective airborne transmission model was established.

Benefits of technology

An airborne transmission system in a ferret model was successfully established, revealing the transmission pattern of IDV among ferrets, providing a scientific basis for early warning and prevention, verifying the airborne transmission capability of IDV in ferrets, and advancing the understanding of the pathogenic mechanism and zoonotic potential of IDV.

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Abstract

The application discloses a D type influenza virus isolate D / HY11 and application thereof in a mink infection model, and belongs to the field of biological medicines. The application takes the D type influenza virus isolate D / HY11 of an IDV northeast isolate as a research object, establishes a mink transmission model, evaluates the transmission dynamics characteristics of the strain among minks, identifies amino acid mutations possibly related to host adaptability through whole genome sequencing, analyzes the amino acid substitution on receptor affinity based on computer simulation of protein conformation and receptor molecule docking, explores the host adaptation evolution law of the virus in the transmission process, and provides an important scientific basis for early warning and prevention and control of a public health crisis possibly caused by the IDV.
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