A weight loss elastic band for reducing weight in stages and shaping the body and a preparation method thereof

Abstract

This invention discloses a multi-stage, gastric-expanding weight loss and body shaping compound and its preparation method, relating to the fields of food processing and pharmaceutical health technology. The compound comprises a core metabolism promoter, micronutrient supplements, a protein base, and an intragastric expansion system consisting of a primary expansion agent and a secondary expansion agent. The primary expansion agent rapidly expands in the stomach, producing an immediate feeling of fullness; the secondary expansion agent is an enteric-coated, sustained-release expanding microsphere, which dissolves its coating and undergoes secondary expansion upon entering the intestines, continuously suppressing hunger through the gastrointestinal reflex. This invention achieves multi-stage, long-lasting appetite control by simulating the physiological satiety process, while simultaneously supplementing enzymes, proteins, vitamins, and minerals. It features enhanced metabolism, balanced nutrition, comfortable experience, and high safety, making it suitable for healthy weight management.

Description

Technical Field

[0001] This invention relates to the fields of food processing and pharmaceutical technology, and more specifically, to a weight-loss compound formulation for weight management that has the function of gradually expanding the stomach volume to mask hunger, and a method for preparing the compound. Background Technology

[0002] With the improvement of living standards, obesity has become increasingly prevalent and a significant factor affecting public health. Currently, there are numerous weight-loss products on the market, mainly including appetite suppressants, fat absorption blockers, and meal replacement powders. However, existing products have many shortcomings: appetite suppressants typically act on the central nervous system, potentially causing side effects such as palpitations and insomnia; meal replacement powders provide a short-lasting feeling of fullness, making it difficult to effectively control food intake at the next meal; and products that rely solely on dietary fiber expansion have uncontrollable expansion speed and degree, potentially leading to excessive fullness and discomfort, or rapid expansion resulting in a short-lived effect. Therefore, developing a weight-loss product that can simulate the fullness process after a normal meal in the stomach, providing a sustained feeling of fullness through gentle, gradual expansion, while also providing nutritional supplementation and promoting metabolism, is of significant practical importance. Summary of the Invention

[0003] The purpose of this invention is to overcome the shortcomings of the prior art and provide a weight loss pellet complex and its preparation method that can expand in the stomach in stages and continuously, thereby effectively masking hunger and synergistically supplementing nutrition and promoting fat metabolism.

[0004] To achieve the above objectives, the present invention provides the following technical solution: a multi-stage gastric expansion slimming and body shaping compound, characterized in that it is composed of a core active ingredient and an intragastric expansion system, comprising the following components by weight: a core metabolic promoter: 10-20 parts of an enzyme-protease mixture; a micronutrient supplement: 15-25 parts of a complex vitamin and a rapid hydration gel; a secondary expansion agent: 10-20 parts of enteric-coated sustained-release expanding microspheres; and a molding aid: 5-10 parts of microcrystalline cellulose, magnesium stearate, etc. Further, the enzyme-protease mixture contains papain, bromelain, and lipase in a ratio of 2:1:1. The complex vitamin contains at least vitamin B6 and B12, and the minerals contain at least calcium, iron, and zinc. Further, the secondary expansion agent is enteric-coated sustained-release expanding microspheres, prepared by using sodium alginate as the core and coating it with an ethyl cellulose enteric coating material. This invention also provides a method for preparing the multi-stage gastric expansion weight loss and body shaping complex, comprising the following steps: Preparation of expandable microspheres: Sodium alginate solution is dropped into a calcium ion solution, solidified into spheres, and dried to obtain calcium alginate core microspheres; using fluidized bed technology, ethyl cellulose coating solution is sprayed onto the outer layer of the core microspheres to form an enteric coating layer, thus obtaining a secondary expander. Mixing and granulation: An enzyme-protease mixture, a mixture of compound vitamins and minerals, a protein base, the primary expander, and some molding aids are added to a wet mixing granulator, an appropriate amount of binder is added, granulation is performed, drying is carried out, and granulation is performed to obtain inner core particles. Total mixing and tableting / filling: The above-mentioned inner core particles, the enteric-coated sustained-release expandable microspheres obtained in step 1, and the remaining molding aids are added to a mixer, and after total mixing is uniform, they are compressed into bullet shapes according to dosage form requirements to obtain the weight loss and body shaping bullet complex. Working Principle and Technical Effects: When the complex (weight-loss pellet) of this invention enters the stomach, gastric juice rapidly dissolves the outer layer. The primary bulking agent (such as konjac glucomannan or guar gum) immediately comes into contact with the gastric juice and begins its first rapid expansion, occupying part of the stomach volume within a short time (approximately 10-20 minutes) and producing an initial feeling of fullness. Simultaneously, the protein matrix begins to denature and dissolve under the action of gastric acid, releasing the encapsulated core metabolic promoters (enzymes / proteases) and micronutrients. The enzymes / proteases begin to initially break down large molecules in food, promoting digestion and metabolism. Meanwhile, the secondary expanding microspheres, treated with enteric coating, maintain their intact shape as they pass through the stomach because their outer coating does not dissolve in acidic gastric juice. When these microspheres enter the small intestine with the chyme, the neutral or weakly alkaline environment within the small intestine causes the enteric coating to dissolve, exposing the core calcium alginate microspheres, which then begin their second expansion. Although this second expansion occurs in the intestines, its physical occupancy effect sends a continuous satiety signal to the brain through the "gastrointestinal reflex" mechanism, thereby effectively suppressing hunger for the next few hours and achieving the goal of controlling appetite in stages and for a long time.Beneficial Effects: Staggered Expansion for Comfort: Utilizing both rapid and slow-release expansion mechanisms, it avoids discomfort caused by sudden excessive stomach expansion, achieving sustained satiety management from before to after meals. Metabolic Boost for Synergistic Weight Loss: While providing a feeling of fullness, it supplements enzymes and proteases, helping to improve the body's digestion and utilization of food and promoting energy metabolism; multivitamins and minerals compensate for nutritional deficiencies during dieting. Balanced Nutrition for Safety and Health: Rich in high-quality protein, it maintains muscle mass and basal metabolic rate during weight loss, aligning with the concept of healthy weight loss. Detailed Implementation

[0005] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. Example 1: Preparation of Secondary Expanded Microspheres: A 2% sodium alginate solution was prepared and dripped into a 2% calcium chloride solution through sharp orifices. After solidification for 30 minutes, calcium alginate microspheres with a particle size of 1 mm were obtained and dried at 40°C to constant weight. The dried microspheres were placed in a fluidized bed and sprayed with an ethyl cellulose ethanol solution (5% concentration) to increase the weight by 15%, thus obtaining enteric-coated sustained-release expanded microspheres. Mixing and Granulation: 8 parts papain, 4 parts bromelain, 4 parts lipase (total 16 parts), 8 parts compound vitamins and minerals (commercially available premix), 25 parts soy protein isolate, 20 parts konjac flour (primary expanding agent), and 5 parts microcrystalline cellulose were mixed evenly. Using purified water as a binder, a soft mass was prepared, granulated through a 20-mesh sieve, dried at 50°C, and then granulated through an 18-mesh sieve. Total Mixing and Tableting: The granules prepared above were mixed evenly with 15 parts of the enteric-coated microspheres prepared in step 1 and 2 parts of magnesium stearate, and compressed into a bouncy tablet weighing approximately 2g. Application Example: Sixty overweight volunteers (BMI > 24) were randomly divided into two groups. The experimental group took 2 tablets of the bouncy formulation of Example 1 of this invention before meals daily, while the control group took an equal amount of placebo. The observation lasted for 8 weeks. The results showed that the experimental group had significantly higher postprandial satiety scores than the control group, and their average daily total calorie intake decreased by approximately 350 kcal. After 8 weeks, the experimental group experienced an average weight loss of 4.2 kg and a waist circumference reduction of 5.1 cm, both significantly better than the control group. No significant gastrointestinal discomfort or other adverse reactions were reported by any volunteers. The above description is only a preferred embodiment of the present invention and is not intended to limit the invention. For those skilled in the art, multiple expansion levels or different coating materials can be designed without departing from the spirit and principle of the present invention, and these improvements should also be considered within the scope of protection of the present invention.

Claims

1. A multi-stage, gastric-expanding, slimming and shaping compound, characterized in that, It comprises: a core metabolic promoter, which is a mixture of enzymes and proteases; a micronutrient supplement, which is a complex of vitamins and minerals; a protein base; and an intragastric expansion system, which includes a primary expansion agent and a secondary expansion agent; the primary expansion agent rapidly hydrates and expands in gastric juice; and the secondary expansion agent is a slow-release expanding microsphere with an enteric coating, which remains intact in gastric juice and undergoes secondary expansion after entering the intestine.

2. The multi-stage gastric expansion type weight loss and body shaping complex according to claim 1, characterized in that, The enzyme-protease mixture contains papain, bromelain and lipase in a mass ratio of (1-3):(1-2):(1-2).

3. The multi-stage gastric expansion type weight loss and body shaping complex according to claim 1, characterized in that, The primary swelling agent is at least one selected from konjac glucomannan, guar gum, and xanthan gum.

4. The multi-stage gastric expansion type weight loss and body shaping complex according to claim 1, characterized in that, The core of the slow-release expanding microspheres in the secondary expanding agent is calcium alginate, and the coating material is ethyl cellulose or polyacrylic acid resin.

5. A method for preparing the multi-stage gastric expansion slimming and body shaping complex as described in any one of claims 1-4, characterized in that, The process includes the following steps: Step a: preparing enteric-coated sustained-release expanded microspheres; Step b: mixing the enzyme-protease mixture, compound vitamins and minerals, protein base, and primary expansion agent, granulating to obtain core particles; Step c: Mix the sustained-release expanded microspheres obtained in step a with the core particles obtained in step b, and add pharmaceutically acceptable excipients to prepare the final dosage form.

6. The preparation method according to claim 5, characterized in that, Step a specifically includes: dripping sodium alginate solution into calcium salt solution, solidifying it into spheres, drying it to obtain calcium alginate core microspheres; and spraying a coating solution onto the core microspheres in a fluidized bed to form an enteric coating layer.