Method for varying pulse width of high voltage pulses according to ablation site

Abstract

This application discloses a high-voltage pulsed ablation technique (PFA) with variable pulse width based on the ablation site, belonging to the field of high-frequency pulse control technology. The method includes selecting and confirming the ablation site on the ablation device display; switching and matching the corresponding pulse width parameters based on the confirmed ablation site; initiating and controlling ablation based on the switched and matched pulse width parameters; determining whether ablation is complete after completion; if not, restarting and controlling ablation again; if complete, determining the end of the current ablation; determining whether the ablation site needs to be changed; if not, restarting and controlling ablation again; if so, reselecting the ablation site for the next ablation. This method allows for ablation with different parameters based on different sites, resulting in less muscle tremor, more thorough tissue ablation, and a reduced recurrence probability. It does not require changes to the original hardware layout or catheter shape, only modifications to the software and algorithm.

Description

Technical Field

[0001] This application belongs to the field of high-frequency pulse control technology, specifically, it relates to a method for varying the pulse width of a high-voltage pulse PFA according to the ablation site. Background Technology

[0002] Currently, high-voltage pulse ablation uses a fixed set of pulse parameters. However, the tissue thickness varies in different parts of the heart, resulting in different ablation depths. Some areas are close to nerves and require parameters that do not damage the nerves, while areas far from the phrenic nerve or thicker areas of the heart require parameters that allow for deeper ablation. Therefore, using a fixed set of parameters is difficult to meet the needs of different situations. Summary of the Invention

[0003] To address the aforementioned problems and technical deficiencies, this application adopts the following technical solution: a method for varying the pulse width of a high-voltage pulsed ablation device (PFA) based on the ablation site, comprising the following steps: Select the ablation site on the ablation device display and confirm the ablation site; Switch the corresponding pulse width parameter according to the confirmed ablation location; Ablation initiation and control are based on the pulse width parameter of the switching match; After ablation is completed, determine whether ablation is finished. If ablation is not finished, restart ablation and control the process again. If ablation is finished, determine that the current ablation is finished. After the ablation is completed, determine whether the ablation site needs to be changed. If the ablation site does not need to be changed, restart the ablation process and control the ablation again. If the ablation site needs to be changed, select a new ablation site for the next ablation.

[0004] Preferably, the ablation initiation and ablation control based on the pulse width parameter of the switching match includes: Obtain the set voltage value, and calculate the optimal pulse width corresponding to the target cell using the transmembrane voltage formula based on the set voltage value; Based on the dose and transmembrane potential accumulation model, the number of equivalent nanosecond pulse sub-pulses that can replace the optimal pulse width is calculated. Based on the total dose set by the optimal pulse width and the equivalent number of nanosecond pulse sub-pulses, the number of pulse trains is calculated, and a nanosecond pulse is fitted based on the number of pulse trains, replacing the optimal pulse width. The calculated number of nanosecond fitting values, the number of pulse trains, and preset parameters are stored in the storage chip of the pulse platform. The pulse platform then calls the stored parameters for energy emission.

[0005] Furthermore, the dosage The calculation formula is as follows: Where V is the voltage amplitude, Tp is the pulse width, n is the number of sub-pulses in each pulse train, and N is the number of pulse trains.

[0006] Furthermore, the ablation dose and depth are directly proportional under predetermined conditions, with the dose being proportional to the square of the voltage. Based on the dose formula and test experimental data, pulse width parameters are configured for different locations.

[0007] Furthermore, near the superior vena cava, the SVC is relatively thin and the phrenic nerve is attached externally. Ablation with deeper energy would cause severe muscle tremors in the patient. Therefore, ablation with shallower energy and a narrow pulse width of 300-1000 ns is used.

[0008] Furthermore, the thickened area of ​​the ventricle is ablated using a wide pulse of energy with a pulse width of 2-6 μs.

[0009] Compared to existing technologies, the beneficial effects of this application are as follows: This application implements ablation with different parameters for different sites, which can reduce muscle tremors, make tissue ablation more thorough and reduce the probability of recurrence, and make patients more comfortable and reduce discomfort. It does not require changes to the original hardware layout and catheter shape, but only changes to the software and algorithm. Attached Figure Description

[0010] In the attached diagram: Figure 1 This is a schematic diagram of the method flow of an embodiment of this application; Figure 2 This is a schematic diagram of the catheter electrode according to an embodiment of this application; Figure 3 This is a table of test data for different pulse widths in embodiments of this application. Detailed Implementation

[0011] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some embodiments of this application, but not all embodiments. Generally, the components of the embodiments of this application described and shown in the accompanying drawings can be arranged and designed in various different configurations.

[0012] Examples, such as Figure 1 As shown, a high-voltage pulsed ablation technique (PFA) with varying pulse width based on the ablation site includes the following steps: Select the ablation site on the ablation device display and confirm the ablation site; Switch the corresponding pulse width parameter according to the confirmed ablation location; Ablation initiation and control are based on the pulse width parameter of the switching match; After ablation is completed, determine whether ablation is finished. If ablation is not finished, restart ablation and control the process again. If ablation is finished, determine that the current ablation is finished. After the ablation is completed, determine whether the ablation site needs to be changed. If the ablation site does not need to be changed, restart the ablation process and control the ablation again. If the ablation site needs to be changed, select a new ablation site for the next ablation.

[0013] Ablation initiation and control based on pulse width parameters for switching matching includes: Obtain the set voltage value, and calculate the optimal pulse width corresponding to the target cell using the transmembrane voltage formula based on the set voltage value; Based on the dose and transmembrane potential accumulation model, the number of equivalent nanosecond pulse sub-pulses that can replace the optimal pulse width is calculated. dose The calculation formula is as follows: Where V is the voltage amplitude, Tp is the pulse width, n is the number of sub-pulses in each pulse train, and N is the number of pulse trains; Based on the total dose set by the optimal pulse width and the equivalent number of nanosecond pulse sub-pulses, the number of pulse trains is calculated, and a nanosecond pulse is fitted based on the number of pulse trains, replacing the optimal pulse width. The calculated number of nanosecond fitting values, the number of pulse trains, and preset parameters are stored in the storage chip of the pulse platform. The pulse platform then calls the stored parameters for energy emission.

[0014] Changing the voltage to change the dosage is somewhat difficult, but changing the pulse width is much easier. Therefore, this invention has made parameter configurations for different positions based on the above formula and the verified test data. Under predetermined conditions, the ablation dose and depth are directly proportional, and the dose is proportional to the square of the voltage. Based on the dose formula and test data, the pulse width parameters for different locations are configured.

[0015] If the atria are relatively thin, a formula with a narrow pulse width can be selected; if the ventricles are thicker, a formula with a wide pulse width can be selected.

[0016] like Figure 2 and Figure 3 As shown, data was measured on a potato using the same catheter electrode. Subsequent improvements to the catheter have achieved significant upgrades, and the effects are not shown here. This is just a part of a previous experiment, intended to reveal that changing the pulse width can achieve depth variations.

[0017] Near the superior vena cava, the SVC is relatively thin and the phrenic nerve is attached externally. Using energy with a deeper ablation depth can cause severe muscle tremors in patients. Therefore, shallower energy ablation is used, with a narrow pulse width of 300~1000ns.

[0018] In the thickened areas of the ventricle, ablation is performed using a wide pulse of energy with a pulse width of 2-6 μs.

[0019] The embodiments described above are merely preferred embodiments of this application, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of this application. It should be noted that those skilled in the art can make various modifications, improvements, and substitutions without departing from the concept of this application, and these all fall within the protection scope of this application.

Claims

1. A method for varying pulse width of a high-voltage pulsed ablation device (PFA) based on the ablation site, characterized in that, Includes the following steps: Select the ablation site on the ablation device display and confirm the ablation site; Switch the corresponding pulse width parameter according to the confirmed ablation location; Ablation initiation and control are based on the pulse width parameter of the switching match; After ablation is completed, determine whether ablation is finished. If ablation is not finished, restart ablation and control the process again. If ablation is finished, determine that the current ablation is finished. After the ablation is completed, determine whether the ablation site needs to be changed. If the ablation site does not need to be changed, restart the ablation process and control the ablation again. If the ablation site needs to be changed, select a new ablation site for the next ablation.

2. The method for varying pulse width of a high-voltage pulse PFA according to the ablation site as described in claim 1, characterized in that, The ablation initiation and ablation control based on the pulse width parameter of the switching match includes: Obtain the set voltage value, and calculate the optimal pulse width corresponding to the target cell using the transmembrane voltage formula based on the set voltage value; Based on the dose and transmembrane potential accumulation model, the number of equivalent nanosecond pulse sub-pulses that can replace the optimal pulse width is calculated. Based on the total dose set by the optimal pulse width and the equivalent number of nanosecond pulse sub-pulses, the number of pulse trains is calculated, and a nanosecond pulse is fitted based on the number of pulse trains, replacing the optimal pulse width. The calculated number of nanosecond fitting values, the number of pulse trains, and preset parameters are stored in the storage chip of the pulse platform. The pulse platform then calls the stored parameters for energy emission.

3. The method for varying pulse width of a high-voltage pulse PFA according to the ablation site as described in claim 2, characterized in that, The dosage The calculation formula is as follows: Where V is the voltage amplitude, Tp is the pulse width, n is the number of sub-pulses in each pulse train, and N is the number of pulse trains.

4. The method for varying pulse width of a high-voltage pulse PFA according to the ablation site as described in claim 2, characterized in that, The ablation dose and depth are directly proportional under predetermined conditions, with the dose being proportional to the square of the voltage. Based on the dose formula and test data, pulse width parameters are configured for different locations.

5. The method for varying pulse width according to the ablation site using high-voltage pulse PFA as described in claim 4, characterized in that, Near the superior vena cava, the SVC is relatively thin and the phrenic nerve is attached externally. Using energy with a deeper ablation depth would cause severe muscle tremors in the patient. Therefore, ablation with shallower energy and a narrow pulse width of 300~1000ns is used.

6. The method for varying pulse width of a high-voltage pulse PFA according to the ablation site as described in claim 5, characterized in that, The procedure involves ablation of the thickened area of ​​the ventricle using a wide pulse of energy, with a pulse width of 2-6 μs.

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