A kind of antifungal compound cream containing traditional Chinese medicine component tryptanthrin and application thereof

By preparing a compound cream of traditional Chinese and Western medicine, and utilizing the combined use of tryptophan and terbinafine hydrochloride, the problems of drug resistance and adverse reactions of existing antifungal drugs have been solved, providing a low-dose and highly effective antifungal treatment regimen, especially with effective antifungal effects against Trichophyton rubrum.

CN122163616APending Publication Date: 2026-06-09THE 900TH HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY JOINT LOGISTICS SUPPORT FORCE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE 900TH HOSPITAL OF THE CHINESE PEOPLES LIBERATION ARMY JOINT LOGISTICS SUPPORT FORCE
Filing Date
2026-05-06
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing antifungal drugs have problems with drug resistance in clinical practice and have many adverse reactions, making them difficult to effectively treat superficial fungal infections such as dermatophyte infections caused by Trichophyton rubrum.

Method used

A compound antifungal cream was prepared by combining the traditional Chinese medicine ingredient tryptophan with the Western medicine terbinafine hydrochloride. By optimizing the ratio of matrix and emulsifier, a low-dose, high-efficiency cream formulation was formed. Combined with the heat-clearing and detoxifying effects of indigo, the antibacterial activity was enhanced.

Benefits of technology

It achieves antifungal effects with low toxicity, high efficiency and low drug resistance, simplifies the preparation process and improves the antifungal activity against Trichophyton rubrum.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention belongs to the field of pharmaceutical chemistry, and specifically relates to a compound antifungal cream containing the traditional Chinese medicine ingredient tryptamine ketone and its application. The invention comprises the following components, with the following percentage content: stearic acid 10%~16%, glyceryl monostearate 3%~7%, liquid paraffin 5%~9%, tryptamine 0.1%~0.01%, terbinafine hydrochloride 0.00625%~0.000625%, glycerin 4%, triethanolamine 2%~6%, ethylparaben 0.5%, and the balance being purified water or distilled water. This invention is highly effective, low in toxicity, and exhibits low drug resistance.
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