4D printing shape memory composite scaffold for delivering exosomes and magnesium ions as well as preparation method and application of 4D printing shape memory composite scaffold

The exosome-magnesium ion synergistic sustained-release shape memory composite scaffold prepared by 4D printing technology solves the problems of limited bone source and insufficient exosome delivery in the treatment of bone defects, and achieves precise fitting and porous structure support to promote bone regeneration.

CN122163914APending Publication Date: 2026-06-09SOUTH CHINA UNIV OF TECH +1
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Patent Information

Application Number
CN202610097005.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-23
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing treatments for bone defects suffer from problems such as limited bone sources, immune rejection, high surgical complexity, and insufficient exosome delivery capacity, making it difficult to achieve long-term sustained release and precise adaptation.

Method used

A shape memory composite scaffold loaded with exosomes and magnesium ions was fabricated using 4D printing technology combined with Pickering emulsion. The exosomes and magnesium oxide were encapsulated by Pickering emulsion to achieve synergistic sustained release of exosomes and magnesium ions. The scaffold has shape memory function and can adapt to irregular bone defects.

Benefits of technology

It achieves synergistic sustained release of exosomes and magnesium ions, promoting osteogenic differentiation. The scaffold can actively deform under body temperature stimulation, precisely conforming to bone defects, reducing surgical damage, and providing a porous structure to support cell migration and nutrient delivery, making it suitable for minimally invasive repair of irregular bone defects.

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Abstract

The invention discloses a 4D printing shape memory composite scaffold for delivering exosomes and magnesium ions as well as a preparation method and application of the 4D printing shape memory composite scaffold. The preparation method comprises the following steps: (1) mixing hydroxyapatite and silicon dioxide nanoparticles with poly (D, L-lactic acid-co-trimethylene carbonate) in dichloromethane to obtain an oil phase; adding an exosome into the magnesium oxide nanoparticle aqueous dispersion to obtain a water phase; mixing is carried out, such that a water-in-oil Pickering emulsion is obtained; and (2) preparing the Pickering emulsion ink by using a 4D printing technology to obtain the composite porous shape memory scaffold (PHS / MgO-EXO) loaded with the exosome. The scaffold has a multi-stage communicated pore structure, and cell osteogenic differentiation and bone tissue regeneration are promoted by synergistically slowly releasing exosomes and magnesium ions. The material also has a temperature-sensitive shape memory function, recovers an initial shape under stimulation slightly higher than body temperature, is accurately matched with irregular bone defects, and is suitable for minimally invasive repair treatment of clinical irregular bone defects.
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